ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	8.59592847
2	positive regulation of uterine smooth muscle contraction (GO:0070474)	6.15695839
3	positive regulation of protein homooligomerization (GO:0032464)	4.95007695
4	cellular response to interferon-alpha (GO:0035457)	4.83225655
5	negative regulation of homotypic cell-cell adhesion (GO:0034111)	4.65082351
6	positive regulation of natural killer cell differentiation (GO:0032825)	4.49913865
7	regulation of uterine smooth muscle contraction (GO:0070472)	4.32395944
8	dopamine biosynthetic process (GO:0042416)	4.26183456
9	positive regulation of defense response to virus by host (GO:0002230)	4.19249390
10	regulation of chronic inflammatory response (GO:0002676)	4.06376326
11	arginine catabolic process (GO:0006527)	4.02146919
12	serotonin metabolic process (GO:0042428)	4.00869788
13	primary amino compound metabolic process (GO:1901160)	3.98778051
14	fucosylation (GO:0036065)	3.97784457
15	detection of light stimulus involved in visual perception (GO:0050908)	3.81563244
16	detection of light stimulus involved in sensory perception (GO:0050962)	3.81563244
17	response to insecticide (GO:0017085)	3.74982869
18	RNA destabilization (GO:0050779)	3.72303078
19	negative regulation of axon guidance (GO:1902668)	3.59992176
20	cochlea development (GO:0090102)	3.59410146
21	positive regulation of monocyte chemotaxis (GO:0090026)	3.43614573
22	lymphocyte apoptotic process (GO:0070227)	3.41855110
23	DNA deamination (GO:0045006)	3.36291928
24	cytidine metabolic process (GO:0046087)	3.31978308
25	cytidine catabolic process (GO:0006216)	3.31978308
26	cytidine deamination (GO:0009972)	3.31978308
27	axoneme assembly (GO:0035082)	3.31742366
28	positive regulation of T-helper 1 type immune response (GO:0002827)	3.28072291
29	alkaloid metabolic process (GO:0009820)	3.25995168
30	lung vasculature development (GO:0060426)	3.25963822
31	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.23900148
32	rRNA catabolic process (GO:0016075)	3.23263087
33	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.12778138
34	proteasome assembly (GO:0043248)	3.12758922
35	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.09884984
36	regulation of natural killer cell differentiation (GO:0032823)	3.08734991
37	N-acetylglucosamine metabolic process (GO:0006044)	3.08529622
38	sulfation (GO:0051923)	3.08267423
39	hemidesmosome assembly (GO:0031581)	3.06368393
40	regulation of isotype switching to IgG isotypes (GO:0048302)	3.05300624
41	cellular biogenic amine biosynthetic process (GO:0042401)	3.04452412
42	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.04286585
43	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.03873149
44	tolerance induction (GO:0002507)	2.99175464
45	response to histamine (GO:0034776)	2.97722463
46	positive regulation of digestive system process (GO:0060456)	2.90712114
47	endoderm formation (GO:0001706)	2.89812149
48	opioid receptor signaling pathway (GO:0038003)	2.84826225
49	catechol-containing compound biosynthetic process (GO:0009713)	2.83778266
50	catecholamine biosynthetic process (GO:0042423)	2.83778266
51	sodium-independent organic anion transport (GO:0043252)	2.82440019
52	regulation of natural killer cell activation (GO:0032814)	2.80847366
53	response to interferon-alpha (GO:0035455)	2.80237907
54	leukocyte apoptotic process (GO:0071887)	2.79620530
55	toxin metabolic process (GO:0009404)	2.79192575
56	amine biosynthetic process (GO:0009309)	2.79018695
57	positive regulation of natural killer cell activation (GO:0032816)	2.78610089
58	mitochondrial calcium ion transport (GO:0006851)	2.78022655
59	purine-containing compound salvage (GO:0043101)	2.76627644
60	positive regulation of protein oligomerization (GO:0032461)	2.75316998
61	regulation of axon guidance (GO:1902667)	2.74681843
62	regulation of monocyte chemotaxis (GO:0090025)	2.73412256
63	macroautophagy (GO:0016236)	2.73257424
64	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.72600306
65	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.68350436
66	retinal cone cell development (GO:0046549)	2.67983911
67	type B pancreatic cell proliferation (GO:0044342)	2.66966705
68	thalamus development (GO:0021794)	2.66139267
69	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.64975925
70	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.64336783
71	establishment of skin barrier (GO:0061436)	2.63069940
72	regulation of catecholamine metabolic process (GO:0042069)	2.62248305
73	regulation of dopamine metabolic process (GO:0042053)	2.62248305
74	regulation of homotypic cell-cell adhesion (GO:0034110)	2.57302213
75	positive regulation of smooth muscle contraction (GO:0045987)	2.56961484
76	multicellular organism reproduction (GO:0032504)	2.55911015
77	regulation of gene silencing by RNA (GO:0060966)	2.55255684
78	regulation of posttranscriptional gene silencing (GO:0060147)	2.55255684
79	regulation of gene silencing by miRNA (GO:0060964)	2.55255684
80	interferon-gamma production (GO:0032609)	2.51621438
81	endodermal cell differentiation (GO:0035987)	2.51356622
82	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.51074695
83	ovulation cycle (GO:0042698)	2.51019221
84	desmosome organization (GO:0002934)	2.50550573
85	metanephric mesenchyme development (GO:0072075)	2.49566943
86	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.49442797
87	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.48703892
88	arginine metabolic process (GO:0006525)	2.46504083
89	positive regulation of cAMP-mediated signaling (GO:0043950)	2.46401958
90	fibroblast migration (GO:0010761)	2.45706558
91	piRNA metabolic process (GO:0034587)	2.44501653
92	kidney mesenchyme development (GO:0072074)	2.43786821
93	negative regulation of astrocyte differentiation (GO:0048712)	2.43554209
94	indolalkylamine metabolic process (GO:0006586)	2.43276336
95	cranial nerve structural organization (GO:0021604)	2.43184700
96	axon extension involved in axon guidance (GO:0048846)	2.42318141
97	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.42318141
98	response to cold (GO:0009409)	2.42043322
99	regulation of T-helper 1 type immune response (GO:0002825)	2.41702237
100	regulation of axon extension involved in axon guidance (GO:0048841)	2.41651916

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	4.73674553
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.47102867
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.97250669
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.25077458
5	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.79565580
6	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.53751894
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47992177
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.34113041
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30133206
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.27397458
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.19022321
12	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.15748236
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11220273
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.06244565
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.00076121
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98181787
17	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.91388496
18	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.91280821
19	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.85072579
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.81364596
21	EWS_26573619_Chip-Seq_HEK293_Human	1.80708866
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.77829165
23	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.75385526
24	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.70600809
25	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.64858991
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.64277386
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.61155163
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.59884045
29	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.59877400
30	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.58358300
31	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.56070692
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.54090716
33	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.53649522
34	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.51297561
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48428295
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47500525
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.45643485
38	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.45070071
39	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.44607950
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42602895
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42602895
42	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.42433259
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.42340120
44	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.42340120
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42339833
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39260035
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39260035
48	RXR_22108803_ChIP-Seq_LS180_Human	1.37315218
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35149856
50	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.34984149
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.34437200
52	TP53_16413492_ChIP-PET_HCT116_Human	1.34424097
53	P300_19829295_ChIP-Seq_ESCs_Human	1.29942774
54	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.28518772
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.28246438
56	STAT3_23295773_ChIP-Seq_U87_Human	1.27977249
57	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.26833285
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.26212778
59	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25372837
60	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.23844907
61	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.23462691
62	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.22402947
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.22313807
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22270301
65	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.21566986
66	CJUN_26792858_Chip-Seq_BT549_Human	1.18088458
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17904507
68	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.17693822
69	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.16590008
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16465771
71	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.15797191
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15767599
73	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15355428
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15191851
75	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.14445181
76	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.12982408
77	TP53_22573176_ChIP-Seq_HFKS_Human	1.12891982
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12156214
79	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.11228575
80	TCF4_23295773_ChIP-Seq_U87_Human	1.10362379
81	AR_21572438_ChIP-Seq_LNCaP_Human	1.09241656
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03337755
83	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.00709131
84	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00582391
85	VDR_24787735_ChIP-Seq_THP-1_Human	1.00235173
86	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.99878562
87	NFYA_21822215_ChIP-Seq_K562_Human	0.99218501
88	ER_23166858_ChIP-Seq_MCF-7_Human	0.98803679
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98451661
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98197087
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.97784617
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97740511
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97740511
94	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.97698789
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97554477
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97318167
97	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.96367263
98	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.96223421
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96090462
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.96034557

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.11040263
2	MP0005075_abnormal_melanosome_morpholog	3.60258072
3	MP0008004_abnormal_stomach_pH	3.38777511
4	MP0003950_abnormal_plasma_membrane	2.81283703
5	MP0001348_abnormal_lacrimal_gland	2.80162048
6	MP0002163_abnormal_gland_morphology	2.74492150
7	MP0001346_abnormal_lacrimal_gland	2.61462336
8	MP0004742_abnormal_vestibular_system	2.49062829
9	MP0006082_CNS_inflammation	2.40009186
10	MP0008875_abnormal_xenobiotic_pharmacok	2.39344979
11	MP0000566_synostosis	2.38339774
12	MP0004381_abnormal_hair_follicle	2.11585118
13	MP0000579_abnormal_nail_morphology	2.07026426
14	MP0001958_emphysema	1.97639851
15	MP0008438_abnormal_cutaneous_collagen	1.92351715
16	MP0000685_abnormal_immune_system	1.88388529
17	MP0003718_maternal_effect	1.82441462
18	MP0001501_abnormal_sleep_pattern	1.80731766
19	MP0005671_abnormal_response_to	1.78792485
20	MP0005623_abnormal_meninges_morphology	1.76595977
21	MP0002876_abnormal_thyroid_physiology	1.71398134
22	MP0001542_abnormal_bone_strength	1.67333986
23	MP0000647_abnormal_sebaceous_gland	1.64382220
24	MP0005275_abnormal_skin_tensile	1.59235696
25	MP0009764_decreased_sensitivity_to	1.59125380
26	MP0005174_abnormal_tail_pigmentation	1.57187942
27	MP0009053_abnormal_anal_canal	1.54368272
28	MP0009785_altered_susceptibility_to	1.49555583
29	MP0000015_abnormal_ear_pigmentation	1.49463818
30	MP0003252_abnormal_bile_duct	1.48431407
31	MP0000427_abnormal_hair_cycle	1.46198361
32	MP0005408_hypopigmentation	1.40665085
33	MP0005171_absent_coat_pigmentation	1.38791840
34	MP0004885_abnormal_endolymph	1.37532324
35	MP0000383_abnormal_hair_follicle	1.36349371
36	MP0005645_abnormal_hypothalamus_physiol	1.35920972
37	MP0003172_abnormal_lysosome_physiology	1.34476946
38	MP0004947_skin_inflammation	1.28663943
39	MP0003763_abnormal_thymus_physiology	1.27224372
40	MP0005595_abnormal_vascular_smooth	1.26066272
41	MP0001324_abnormal_eye_pigmentation	1.23111513
42	MP0002796_impaired_skin_barrier	1.22663670
43	MP0001293_anophthalmia	1.22186992
44	MP0008872_abnormal_physiological_respon	1.21301593
45	MP0005387_immune_system_phenotype	1.18485976
46	MP0001790_abnormal_immune_system	1.18485976
47	MP0004084_abnormal_cardiac_muscle	1.14263534
48	MP0003315_abnormal_perineum_morphology	1.08782250
49	MP0005000_abnormal_immune_tolerance	1.07943393
50	MP0005083_abnormal_biliary_tract	1.06906584
51	MP0000534_abnormal_ureter_morphology	1.06319064
52	MP0009745_abnormal_behavioral_response	1.04820138
53	MP0003705_abnormal_hypodermis_morpholog	1.03277164
54	MP0008007_abnormal_cellular_replicative	1.03033447
55	MP0002148_abnormal_hypersensitivity_rea	1.02918951
56	MP0002234_abnormal_pharynx_morphology	1.02129469
57	MP0005257_abnormal_intraocular_pressure	1.00522088
58	MP0009697_abnormal_copulation	0.97885125
59	MP0000026_abnormal_inner_ear	0.97671872
60	MP0002060_abnormal_skin_morphology	0.97147079
61	MP0003448_altered_tumor_morphology	0.95543307
62	MP0005379_endocrine/exocrine_gland_phen	0.94150194
63	MP0001533_abnormal_skeleton_physiology	0.91904200
64	MP0003436_decreased_susceptibility_to	0.90107205
65	MP0005187_abnormal_penis_morphology	0.87489266
66	MP0005023_abnormal_wound_healing	0.87150582
67	MP0005197_abnormal_uvea_morphology	0.86607117
68	MP0002332_abnormal_exercise_endurance	0.86289725
69	MP0001216_abnormal_epidermal_layer	0.85970557
70	MP0003942_abnormal_urinary_system	0.85246140
71	MP0002160_abnormal_reproductive_system	0.85113047
72	MP0009250_abnormal_appendicular_skeleto	0.85059487
73	MP0005503_abnormal_tendon_morphology	0.84727701
74	MP0002102_abnormal_ear_morphology	0.84645953
75	MP0003646_muscle_fatigue	0.83215845
76	MP0002693_abnormal_pancreas_physiology	0.81260959
77	MP0003045_fibrosis	0.81036671
78	MP0005389_reproductive_system_phenotype	0.80566417
79	MP0002295_abnormal_pulmonary_circulatio	0.80260283
80	MP0010678_abnormal_skin_adnexa	0.79387843
81	MP0005501_abnormal_skin_physiology	0.79089033
82	MP0008877_abnormal_DNA_methylation	0.78808498
83	MP0003880_abnormal_central_pattern	0.76729241
84	MP0003879_abnormal_hair_cell	0.76524213
85	MP0001119_abnormal_female_reproductive	0.76184903
86	MP0005508_abnormal_skeleton_morphology	0.74787504
87	MP0009840_abnormal_foam_cell	0.74371342
88	MP0003638_abnormal_response/metabolism_	0.74099930
89	MP0005025_abnormal_response_to	0.73180626
90	MP0002184_abnormal_innervation	0.72237475
91	MP0005390_skeleton_phenotype	0.72026807
92	MP0002089_abnormal_postnatal_growth/wei	0.71998080
93	MP0002095_abnormal_skin_pigmentation	0.71646760
94	MP0001944_abnormal_pancreas_morphology	0.71232403
95	MP0002736_abnormal_nociception_after	0.71197605
96	MP0002928_abnormal_bile_duct	0.70924703
97	MP0003755_abnormal_palate_morphology	0.68380248
98	MP0000537_abnormal_urethra_morphology	0.67191057
99	MP0003279_aneurysm	0.66999481
100	MP0002006_tumorigenesis	0.65013671

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/hypoplasia of the uterus (HP:0008684)	4.30469335
2	Increased IgM level (HP:0003496)	4.22804628
3	Radial bowing (HP:0002986)	4.02849607
4	Conical tooth (HP:0000698)	4.01295282
5	Aplastic anemia (HP:0001915)	3.46765679
6	Type II lissencephaly (HP:0007260)	3.46733856
7	Eosinophilia (HP:0001880)	3.46329922
8	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	3.45627519
9	IgG deficiency (HP:0004315)	3.45049355
10	Spondylolisthesis (HP:0003302)	3.43165249
11	Autoimmune thrombocytopenia (HP:0001973)	3.42442614
12	Abnormality of dentin (HP:0010299)	3.36092443
13	Hypoplasia of the uterus (HP:0000013)	3.32888021
14	Hypoplastic nipples (HP:0002557)	3.26947741
15	Hypothermia (HP:0002045)	3.15713284
16	Abnormality of the middle phalanges of the toes (HP:0010183)	3.13907904
17	Fibular aplasia (HP:0002990)	3.07799171
18	Increased intramyocellular lipid droplets (HP:0012240)	2.96325229
19	Fair hair (HP:0002286)	2.93636396
20	Adactyly (HP:0009776)	2.92508116
21	Femoral bowing (HP:0002980)	2.85633200
22	Abnormality of incisor morphology (HP:0011063)	2.85509528
23	Hypoplastic labia majora (HP:0000059)	2.84094608
24	Thick nail (HP:0001805)	2.83701690
25	Bowed forearm bones (HP:0003956)	2.82333664
26	Bowing of the arm (HP:0006488)	2.82333664
27	Severe visual impairment (HP:0001141)	2.81245591
28	Abnormality of B cell number (HP:0010975)	2.71699028
29	Focal motor seizures (HP:0011153)	2.70646015
30	Abnormality of the labia majora (HP:0012881)	2.67230197
31	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.63950064
32	Generalized hypopigmentation of hair (HP:0011358)	2.62627019
33	Breast hypoplasia (HP:0003187)	2.54707905
34	Concave nail (HP:0001598)	2.53653543
35	Retinal dysplasia (HP:0007973)	2.52923615
36	Abnormality of macular pigmentation (HP:0008002)	2.50295912
37	Optic neuritis (HP:0100653)	2.40280191
38	Retrobulbar optic neuritis (HP:0100654)	2.40280191
39	Anhidrosis (HP:0000970)	2.40111605
40	Autoimmune hemolytic anemia (HP:0001890)	2.39560294
41	Abnormal pupillary function (HP:0007686)	2.39282572
42	Increased hepatocellular lipid droplets (HP:0006565)	2.37383322
43	B lymphocytopenia (HP:0010976)	2.36332627
44	Increased muscle lipid content (HP:0009058)	2.30750236
45	Exertional dyspnea (HP:0002875)	2.29720640
46	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.27636531
47	Abnormality of alanine metabolism (HP:0010916)	2.27636531
48	Hyperalaninemia (HP:0003348)	2.27636531
49	Granulocytopenia (HP:0001913)	2.26658743
50	Recurrent corneal erosions (HP:0000495)	2.24358090
51	Cheilitis (HP:0100825)	2.22660106
52	Blepharitis (HP:0000498)	2.20258535
53	Ridged nail (HP:0001807)	2.19394773
54	Progressive inability to walk (HP:0002505)	2.19316404
55	Inability to walk (HP:0002540)	2.19167294
56	Cerebellar dysplasia (HP:0007033)	2.18725802
57	Albinism (HP:0001022)	2.18670184
58	Anterior segment dysgenesis (HP:0007700)	2.18424519
59	IgA deficiency (HP:0002720)	2.18204729
60	Petechiae (HP:0000967)	2.18186778
61	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.16936647
62	Corneal dystrophy (HP:0001131)	2.14660880
63	Annular pancreas (HP:0001734)	2.13583854
64	Follicular hyperkeratosis (HP:0007502)	2.13124080
65	Ankle contracture (HP:0006466)	2.12120066
66	3-Methylglutaconic aciduria (HP:0003535)	2.11673038
67	Hemorrhage of the eye (HP:0011885)	2.08319322
68	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.07321342
69	Septate vagina (HP:0001153)	2.06886734
70	Abnormality of eosinophils (HP:0001879)	2.06759741
71	Synostosis involving the elbow (HP:0003938)	2.06075552
72	Humeroradial synostosis (HP:0003041)	2.06075552
73	Premature skin wrinkling (HP:0100678)	2.04537150
74	Lipid accumulation in hepatocytes (HP:0006561)	2.03983533
75	Abnormality of the renal cortex (HP:0011035)	2.03903090
76	Mesomelia (HP:0003027)	2.02738277
77	Limb dystonia (HP:0002451)	2.01969189
78	Corneal erosion (HP:0200020)	2.01672333
79	Orchitis (HP:0100796)	2.00761758
80	Congenital stationary night blindness (HP:0007642)	2.00693518
81	Short nail (HP:0001799)	1.99967415
82	Central scotoma (HP:0000603)	1.99486642
83	Tibial bowing (HP:0002982)	1.98249235
84	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.96927773
85	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.96927773
86	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.95834425
87	Abnormality of the distal phalanges of the toes (HP:0010182)	1.94741728
88	Fragile nails (HP:0001808)	1.93773502
89	Plantar hyperkeratosis (HP:0007556)	1.93542189
90	Keratoconjunctivitis (HP:0001096)	1.90597998
91	Abnormal finger flexion creases (HP:0006143)	1.90059798
92	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.89342679
93	Renal Fanconi syndrome (HP:0001994)	1.88109776
94	Oligodactyly (hands) (HP:0001180)	1.86524256
95	Self-mutilation (HP:0000742)	1.84405618
96	Short middle phalanx of the 5th finger (HP:0004220)	1.84094956
97	Hemoptysis (HP:0002105)	1.82674363
98	Abnormal hair laboratory examination (HP:0003328)	1.81438858
99	Keratitis (HP:0000491)	1.80306799
100	Limb hypertonia (HP:0002509)	1.79000226

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK2	4.83947746
2	ARAF	3.82140694
3	MAP3K12	3.10526929
4	BCR	2.96224492
5	ADRBK2	2.77921004
6	BRD4	2.59999166
7	TXK	2.58963351
8	MAP3K13	2.22375277
9	NEK2	2.13921306
10	BRAF	2.13822630
11	IKBKB	2.07940251
12	NUAK1	2.05986031
13	MAP3K9	1.96468674
14	TAOK3	1.92241730
15	MAP4K2	1.90932301
16	GRK7	1.90769113
17	PIM2	1.90015371
18	MAPK13	1.87079611
19	PIK3CA	1.85293958
20	NTRK3	1.82968435
21	TLK1	1.76718681
22	EPHB2	1.76037299
23	MYLK	1.75665064
24	DMPK	1.74350492
25	RAF1	1.66621044
26	MOS	1.58745399
27	NEK6	1.54584052
28	MAP2K6	1.47536998
29	EIF2AK1	1.37084975
30	FRK	1.36857319
31	ACVR1B	1.35705086
32	GRK6	1.35000201
33	MAP3K14	1.30732957
34	KSR1	1.30290406
35	GRK1	1.29709508
36	JAK3	1.22919006
37	BUB1	1.22648629
38	TGFBR1	1.20799026
39	NEK9	1.16709960
40	PRKCI	1.12066837
41	TEC	1.04532783
42	ADRBK1	1.02812617
43	TBK1	1.00137552
44	MAPK11	0.95729932
45	DDR2	0.88654707
46	WNK3	0.81081366
47	CHUK	0.78896862
48	TGFBR2	0.78800294
49	NLK	0.78438591
50	IKBKE	0.77765133
51	FLT3	0.71541298
52	GRK5	0.70605856
53	PRKCG	0.70437814
54	MAPKAPK3	0.68562507
55	MARK1	0.67228048
56	CDK19	0.66698015
57	PRKCD	0.65539240
58	FGFR2	0.64847284
59	MAP3K7	0.64160728
60	NTRK1	0.62119092
61	LATS2	0.59008156
62	CHEK2	0.58642407
63	MAPK10	0.55778025
64	MST1R	0.55126298
65	MAP2K1	0.53882031
66	EEF2K	0.52526574
67	INSR	0.52447413
68	PRKCH	0.52147196
69	PRKCE	0.52124080
70	CDK8	0.51836490
71	PNCK	0.51435543
72	OXSR1	0.50253698
73	CDK3	0.50249513
74	ROCK1	0.48495695
75	CDK12	0.46834066
76	EIF2AK2	0.46157922
77	PKN1	0.46020471
78	PAK1	0.43789421
79	MAPKAPK5	0.41488759
80	LMTK2	0.40690583
81	ILK	0.40584269
82	CDK4	0.40381889
83	CSK	0.39778914
84	CSNK1D	0.39594837
85	PAK2	0.38264503
86	PRKCA	0.34045327
87	CSF1R	0.33255397
88	KSR2	0.31795471
89	MAPK9	0.30910051
90	PDK1	0.28862025
91	TRPM7	0.28393496
92	CAMK2A	0.27979337
93	PRKACA	0.27558967
94	PRKG1	0.27310081
95	PLK1	0.26921825
96	MAP3K10	0.25762581
97	ZAK	0.25713295
98	RPS6KB1	0.25498661
99	PHKG2	0.24902664
100	PHKG1	0.24902664

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.63271256
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.11029501
3	Nicotine addiction_Homo sapiens_hsa05033	3.00428858
4	Caffeine metabolism_Homo sapiens_hsa00232	2.61263736
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.60299964
6	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.51113951
7	Basal transcription factors_Homo sapiens_hsa03022	2.37648905
8	Phototransduction_Homo sapiens_hsa04744	2.18865531
9	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	2.13346178
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.07762198
11	ECM-receptor interaction_Homo sapiens_hsa04512	2.03062486
12	Phenylalanine metabolism_Homo sapiens_hsa00360	1.88876468
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.85810061
14	African trypanosomiasis_Homo sapiens_hsa05143	1.81093270
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.63576779
16	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.57904391
17	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.53945088
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.50079331
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.40378776
20	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.34517781
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.32639431
22	TNF signaling pathway_Homo sapiens_hsa04668	1.30370688
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29997538
24	Allograft rejection_Homo sapiens_hsa05330	1.23759663
25	Serotonergic synapse_Homo sapiens_hsa04726	1.19937449
26	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.15490406
27	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.14993090
28	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.12811063
29	Salivary secretion_Homo sapiens_hsa04970	1.11686472
30	Morphine addiction_Homo sapiens_hsa05032	1.08770219
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.07861906
32	Olfactory transduction_Homo sapiens_hsa04740	1.05755166
33	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.05080433
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.00787828
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.00280513
36	Sulfur metabolism_Homo sapiens_hsa00920	0.97675515
37	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.94691527
38	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.94544198
39	RNA degradation_Homo sapiens_hsa03018	0.92402089
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.91055774
41	GABAergic synapse_Homo sapiens_hsa04727	0.89942263
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88587232
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88223009
44	Taste transduction_Homo sapiens_hsa04742	0.88156630
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.86227410
46	Small cell lung cancer_Homo sapiens_hsa05222	0.84713198
47	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.83761380
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.83042393
49	Tyrosine metabolism_Homo sapiens_hsa00350	0.82883601
50	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.79617478
51	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.78761771
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.78712898
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78316347
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78012868
55	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.77733626
56	Apoptosis_Homo sapiens_hsa04210	0.76818675
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.76570651
58	Long-term depression_Homo sapiens_hsa04730	0.75117253
59	Focal adhesion_Homo sapiens_hsa04510	0.73510023
60	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.67787971
61	Histidine metabolism_Homo sapiens_hsa00340	0.66861983
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66073296
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65952634
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.64705228
65	Proteasome_Homo sapiens_hsa03050	0.64666239
66	Choline metabolism in cancer_Homo sapiens_hsa05231	0.62110522
67	Hepatitis B_Homo sapiens_hsa05161	0.61559676
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.60664391
69	Amphetamine addiction_Homo sapiens_hsa05031	0.60461726
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.60029164
71	Cocaine addiction_Homo sapiens_hsa05030	0.58596273
72	Malaria_Homo sapiens_hsa05144	0.58259149
73	Melanoma_Homo sapiens_hsa05218	0.57511913
74	Chemokine signaling pathway_Homo sapiens_hsa04062	0.54799085
75	Alzheimers disease_Homo sapiens_hsa05010	0.54058589
76	Asthma_Homo sapiens_hsa05310	0.52380636
77	Circadian entrainment_Homo sapiens_hsa04713	0.52309469
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.52047349
79	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.51140776
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.48747359
81	Toxoplasmosis_Homo sapiens_hsa05145	0.46658040
82	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.46593047
83	Prion diseases_Homo sapiens_hsa05020	0.45825947
84	Purine metabolism_Homo sapiens_hsa00230	0.45249347
85	Protein export_Homo sapiens_hsa03060	0.43434744
86	Parkinsons disease_Homo sapiens_hsa05012	0.42897116
87	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42576548
88	MAPK signaling pathway_Homo sapiens_hsa04010	0.42190665
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41990882
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40566269
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.40283834
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40027946
93	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39965952
94	Measles_Homo sapiens_hsa05162	0.39885674
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38598045
96	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.38577094
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38383745
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.36761649
99	RNA polymerase_Homo sapiens_hsa03020	0.36158983
100	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35453926

CNOT6LP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »