CNOT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of DNA-dependent DNA replication (GO:2000105)7.68963985
2synaptic vesicle endocytosis (GO:0048488)7.42505328
3negative regulation of meiosis (GO:0045835)4.91628242
4N-terminal protein amino acid acetylation (GO:0006474)4.76341366
5N-glycan processing (GO:0006491)4.69563783
6rRNA methylation (GO:0031167)4.57060767
7regulation of meiosis I (GO:0060631)4.50897624
8DNA double-strand break processing (GO:0000729)4.43300542
9regulation of meiosis (GO:0040020)4.30725860
10mitotic sister chromatid cohesion (GO:0007064)4.16800979
11RNA localization (GO:0006403)4.11460584
12maintenance of protein location in nucleus (GO:0051457)4.05723822
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90747904
14rRNA modification (GO:0000154)3.87944317
15proteasome assembly (GO:0043248)3.85692319
16replicative senescence (GO:0090399)3.73107628
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.63778860
18protein K6-linked ubiquitination (GO:0085020)3.62825462
19N-terminal protein amino acid modification (GO:0031365)3.62679049
20neuron fate determination (GO:0048664)3.59808232
21histone H2A acetylation (GO:0043968)3.54724661
22negative regulation of hormone metabolic process (GO:0032351)3.53616830
23negative regulation of hormone biosynthetic process (GO:0032353)3.53616830
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52645179
25CENP-A containing nucleosome assembly (GO:0034080)3.50090108
26chromatin remodeling at centromere (GO:0031055)3.48735465
27regulation of synapse maturation (GO:0090128)3.47621826
28piRNA metabolic process (GO:0034587)3.46918873
29cerebral cortex radially oriented cell migration (GO:0021799)3.45018421
30negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.44947785
31positive regulation of synapse maturation (GO:0090129)3.44314380
32* RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.43594824
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41292219
34mitotic metaphase plate congression (GO:0007080)3.39751402
35regulation of meiotic cell cycle (GO:0051445)3.38273769
36replication fork processing (GO:0031297)3.36841256
37negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36516641
38inositol phosphate dephosphorylation (GO:0046855)3.33521096
39phosphorylated carbohydrate dephosphorylation (GO:0046838)3.33521096
40regulation of histone H3-K27 methylation (GO:0061085)3.30324960
41inositol phosphate catabolic process (GO:0071545)3.25532509
42DNA deamination (GO:0045006)3.22412417
43negative regulation of meiotic cell cycle (GO:0051447)3.21972357
44water-soluble vitamin biosynthetic process (GO:0042364)3.21187517
45histone exchange (GO:0043486)3.18826968
46sister chromatid cohesion (GO:0007062)3.18064026
47behavioral response to nicotine (GO:0035095)3.16024707
48mitotic chromosome condensation (GO:0007076)3.14147974
49monoubiquitinated protein deubiquitination (GO:0035520)3.12982894
50oocyte maturation (GO:0001556)3.08255234
51regulation of synaptic vesicle transport (GO:1902803)3.07751757
52neural tube formation (GO:0001841)3.02996591
53female gamete generation (GO:0007292)3.01642634
54recombinational repair (GO:0000725)2.97704856
55double-strand break repair via homologous recombination (GO:0000724)2.97050414
56* nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96558410
57somatic hypermutation of immunoglobulin genes (GO:0016446)2.93898780
58somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93898780
59synaptic transmission, glutamatergic (GO:0035249)2.93726782
60* exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92972519
61negative regulation of DNA-dependent DNA replication (GO:2000104)2.92808053
62negative regulation of circadian rhythm (GO:0042754)2.92548248
63maturation of 5.8S rRNA (GO:0000460)2.90724514
64DNA damage response, signal transduction resulting in transcription (GO:0042772)2.90683051
65synapsis (GO:0007129)2.89360449
66histone H2A monoubiquitination (GO:0035518)2.89180329
67male meiosis (GO:0007140)2.87482580
68regulation of mitotic spindle checkpoint (GO:1903504)2.87415368
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87415368
70behavioral fear response (GO:0001662)2.87334888
71behavioral defense response (GO:0002209)2.87334888
72stress granule assembly (GO:0034063)2.86438693
73positive regulation of mitochondrial fission (GO:0090141)2.86357256
74regulation of DNA-dependent DNA replication (GO:0090329)2.86112620
75inositol metabolic process (GO:0006020)2.85458877
76metaphase plate congression (GO:0051310)2.85050721
77glycosphingolipid biosynthetic process (GO:0006688)2.84750090
78positive regulation of neuroblast proliferation (GO:0002052)2.84639541
79pyrimidine nucleobase catabolic process (GO:0006208)2.83414798
80positive regulation of dendritic spine morphogenesis (GO:0061003)2.83090482
81DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82501989
82regulation of glutamate receptor signaling pathway (GO:1900449)2.81843974
83regulation of nuclear cell cycle DNA replication (GO:0033262)2.81068160
84behavioral response to ethanol (GO:0048149)2.80634169
85DNA replication-dependent nucleosome organization (GO:0034723)2.80362878
86DNA replication-dependent nucleosome assembly (GO:0006335)2.80362878
87response to prostaglandin E (GO:0034695)2.80137630
88DNA methylation involved in gamete generation (GO:0043046)2.79274885
89neuronal action potential (GO:0019228)2.77866597
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.77790329
91cerebellum development (GO:0021549)2.77698877
92microtubule depolymerization (GO:0007019)2.75266538
93DNA alkylation (GO:0006305)2.75245174
94DNA methylation (GO:0006306)2.75245174
95positive regulation of protein depolymerization (GO:1901881)2.73343283
96ionotropic glutamate receptor signaling pathway (GO:0035235)2.71766523
97regulation of hexokinase activity (GO:1903299)2.70695585
98regulation of glucokinase activity (GO:0033131)2.70695585
99regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.70571783
100organelle disassembly (GO:1903008)2.69885832
101DNA catabolic process, exonucleolytic (GO:0000738)2.69855981
102somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.68621768
103somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.68621768
104isotype switching (GO:0045190)2.68621768
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.68096317
106type B pancreatic cell development (GO:0003323)2.67953830
107positive regulation of cell cycle checkpoint (GO:1901978)2.67707329
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67014254
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67014254
110response to pheromone (GO:0019236)2.65612869
111regulation of long-term neuronal synaptic plasticity (GO:0048169)2.65514010
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.65278674
113NADH dehydrogenase complex assembly (GO:0010257)2.65278674
114mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65278674
115attachment of spindle microtubules to kinetochore (GO:0008608)2.65100616
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65030407
117cullin deneddylation (GO:0010388)2.64649293
118regulation of centriole replication (GO:0046599)2.63791231
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63765320
120kidney morphogenesis (GO:0060993)2.62865612
121branched-chain amino acid catabolic process (GO:0009083)2.62787687
122respiratory chain complex IV assembly (GO:0008535)2.62388195
123histone mRNA metabolic process (GO:0008334)2.61920413
124synaptic vesicle transport (GO:0048489)2.59207302
125establishment of synaptic vesicle localization (GO:0097480)2.59207302
126sister chromatid segregation (GO:0000819)2.59150879
127aggressive behavior (GO:0002118)2.58860353
128amine biosynthetic process (GO:0009309)2.58684437
129cellular biogenic amine biosynthetic process (GO:0042401)2.58684437
130protein polyglutamylation (GO:0018095)2.58460828
131protein complex biogenesis (GO:0070271)2.58075606
132negative regulation of histone methylation (GO:0031061)2.57560588
133reflex (GO:0060004)2.57008792
134positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.56976088
135spindle checkpoint (GO:0031577)2.55714706
136regulation of sister chromatid cohesion (GO:0007063)2.55696258
137reciprocal meiotic recombination (GO:0007131)2.55434614
138reciprocal DNA recombination (GO:0035825)2.55434614
139DNA damage induced protein phosphorylation (GO:0006975)2.54321692
140regulation of retinoic acid receptor signaling pathway (GO:0048385)2.54276785
141histone H4-K12 acetylation (GO:0043983)2.54090943
142establishment of chromosome localization (GO:0051303)2.54022697
143regulation of transforming growth factor beta2 production (GO:0032909)2.54006112
144regulation of female gonad development (GO:2000194)2.53154016
145presynaptic membrane assembly (GO:0097105)2.51870905
146DNA replication-independent nucleosome assembly (GO:0006336)2.51642449
147DNA replication-independent nucleosome organization (GO:0034724)2.51642449
148dosage compensation (GO:0007549)2.51080750
149postreplication repair (GO:0006301)2.50755299
150mitochondrial respiratory chain complex assembly (GO:0033108)2.50554376
151serotonin metabolic process (GO:0042428)2.50411453
152negative regulation of DNA-templated transcription, elongation (GO:0032785)2.49151201
153negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.49151201
154negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.46938066
155mitotic sister chromatid segregation (GO:0000070)2.46754711
156DNA replication checkpoint (GO:0000076)2.44515625
157positive regulation of meiosis (GO:0045836)2.44496756
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.43207952
159resolution of meiotic recombination intermediates (GO:0000712)2.42774890
160L-fucose catabolic process (GO:0042355)2.42492747
161fucose catabolic process (GO:0019317)2.42492747
162L-fucose metabolic process (GO:0042354)2.42492747
163mitotic spindle checkpoint (GO:0071174)2.42473474
164regulation of action potential (GO:0098900)2.42285567
165maintenance of protein localization in organelle (GO:0072595)2.41380178
166negative regulation of nuclear division (GO:0051784)2.41329821
167DNA damage response, detection of DNA damage (GO:0042769)2.41043261
168nucleobase catabolic process (GO:0046113)2.40336693
169ribonucleoprotein complex disassembly (GO:0032988)2.40027380
170protein deneddylation (GO:0000338)2.39230211
171S-adenosylmethionine metabolic process (GO:0046500)2.35936513
172double-strand break repair via nonhomologous end joining (GO:0006303)2.35741817
173non-recombinational repair (GO:0000726)2.35741817
174retinal cone cell development (GO:0046549)2.34396784
175GPI anchor metabolic process (GO:0006505)2.34380115
176preassembly of GPI anchor in ER membrane (GO:0016254)2.34374640
177platelet dense granule organization (GO:0060155)2.33990095
178kynurenine metabolic process (GO:0070189)2.33775495
179pseudouridine synthesis (GO:0001522)2.32988072
180centriole replication (GO:0007099)2.32910944
181righting reflex (GO:0060013)2.32390851
182protein K11-linked ubiquitination (GO:0070979)2.31849912
183gamma-aminobutyric acid transport (GO:0015812)2.31792610
184magnesium ion transport (GO:0015693)2.30248521
185ubiquinone metabolic process (GO:0006743)2.29988513
186primary amino compound metabolic process (GO:1901160)2.28964090
187protein K48-linked ubiquitination (GO:0070936)2.27964806
188regulation of development, heterochronic (GO:0040034)2.27687282
189nonmotile primary cilium assembly (GO:0035058)2.27582788
190protein-cofactor linkage (GO:0018065)2.27477286
191mismatch repair (GO:0006298)2.27180868
192L-methionine biosynthetic process (GO:0071265)2.26084544
193amino acid salvage (GO:0043102)2.26084544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.59882837
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.57583344
3ZNF274_21170338_ChIP-Seq_K562_Hela3.30777752
4IGF1R_20145208_ChIP-Seq_DFB_Human2.87507450
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.85151871
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74010841
7GBX2_23144817_ChIP-Seq_PC3_Human2.67916130
8VDR_22108803_ChIP-Seq_LS180_Human2.57809450
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.31878760
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.26932465
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.26167552
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23736706
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22993922
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22191209
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17380058
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.14880231
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.12944159
18AR_21572438_ChIP-Seq_LNCaP_Human2.11486834
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07157410
20E2F7_22180533_ChIP-Seq_HELA_Human2.05591784
21ELK1_19687146_ChIP-ChIP_HELA_Human1.96214276
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94786276
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93700646
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89691168
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89662166
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.86272963
27EWS_26573619_Chip-Seq_HEK293_Human1.84819530
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84293372
29RNF2_27304074_Chip-Seq_NSC_Mouse1.82881866
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72297766
31TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.70031486
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69703478
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69703478
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68329574
35* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67689601
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67366438
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66205564
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64173259
39MYC_18940864_ChIP-ChIP_HL60_Human1.63719144
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61095655
41STAT3_23295773_ChIP-Seq_U87_Human1.60881021
42VDR_23849224_ChIP-Seq_CD4+_Human1.60525624
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58233035
44REST_21632747_ChIP-Seq_MESCs_Mouse1.57746640
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57301601
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56648415
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56216415
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54210601
49FUS_26573619_Chip-Seq_HEK293_Human1.54045706
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53455628
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51164005
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50165093
53P300_19829295_ChIP-Seq_ESCs_Human1.49980562
54IRF1_19129219_ChIP-ChIP_H3396_Human1.47619909
55ER_23166858_ChIP-Seq_MCF-7_Human1.47261708
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45466971
57CBP_20019798_ChIP-Seq_JUKART_Human1.45466971
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45358263
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44358021
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41780579
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.40707973
62LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40215880
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40180421
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.39864709
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.39574539
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39476647
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39121485
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38180147
69SMAD4_21799915_ChIP-Seq_A2780_Human1.36495870
70AR_25329375_ChIP-Seq_VCAP_Human1.35858244
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35807779
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35736797
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.34970605
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34250940
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33990452
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32913641
77YAP1_20516196_ChIP-Seq_MESCs_Mouse1.32148276
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31201843
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.30564412
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30126138
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30071966
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.29376181
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28759980
84TP53_22573176_ChIP-Seq_HFKS_Human1.26780904
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26670749
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25493302
87BCAT_22108803_ChIP-Seq_LS180_Human1.25478993
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25012253
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24392315
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23875885
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.22429138
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.22065262
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.21743994
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20970709
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.20859141
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19677036
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.19007204
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.17684191
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15579043
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14877998
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14534416
102NANOG_19829295_ChIP-Seq_ESCs_Human1.14164320
103SOX2_19829295_ChIP-Seq_ESCs_Human1.14164320
104TCF4_23295773_ChIP-Seq_U87_Human1.14098252
105FOXP3_21729870_ChIP-Seq_TREG_Human1.13889231
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.13223834
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12623322
108TCF4_22108803_ChIP-Seq_LS180_Human1.11991868
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11815174
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11404227
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11248025
112CRX_20693478_ChIP-Seq_RETINA_Mouse1.11199609
113NOTCH1_21737748_ChIP-Seq_TLL_Human1.10577465
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.10221705
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.10151890
116TAF15_26573619_Chip-Seq_HEK293_Human1.08826620
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.08519807
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08217763
119KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07657950
120REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07428905
121RUNX2_22187159_ChIP-Seq_PCA_Human1.07273035
122FOXA1_25329375_ChIP-Seq_VCAP_Human1.06027609
123FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06027609
124WDR5_24793694_ChIP-Seq_LNCAP_Human1.05839024
125AR_21909140_ChIP-Seq_LNCAP_Human1.05597576
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05343215
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.05295955
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05141280
129SOX9_26525672_Chip-Seq_HEART_Mouse1.04718997
130AHR_22903824_ChIP-Seq_MCF-7_Human1.04394676
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03978405
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.03938294
133E2F1_18555785_Chip-Seq_ESCs_Mouse1.03828718
134RNF2_27304074_Chip-Seq_ESCs_Mouse1.03749850
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03270931
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02895729
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01967060
138JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01648931
139POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.01480641
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00958565
141CMYC_18555785_Chip-Seq_ESCs_Mouse1.00811280
142AR_19668381_ChIP-Seq_PC3_Human1.00569383
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00287260
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99892504
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99439220
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.99119640
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98375557
148SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98018961
149P53_22387025_ChIP-Seq_ESCs_Mouse0.97176720
150JUN_21703547_ChIP-Seq_K562_Human0.96670849
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.95481077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.95498471
2MP0002102_abnormal_ear_morphology3.62663393
3MP0004859_abnormal_synaptic_plasticity3.18963834
4MP0003123_paternal_imprinting3.09890008
5MP0000516_abnormal_urinary_system2.88541167
6MP0005367_renal/urinary_system_phenotyp2.88541167
7MP0003195_calcinosis2.49956750
8MP0002234_abnormal_pharynx_morphology2.41421943
9MP0003121_genomic_imprinting2.30282201
10MP0003787_abnormal_imprinting2.26933800
11MP0008058_abnormal_DNA_repair2.26060460
12MP0008789_abnormal_olfactory_epithelium2.18067127
13MP0008877_abnormal_DNA_methylation2.08538179
14MP0005499_abnormal_olfactory_system2.04481793
15MP0005394_taste/olfaction_phenotype2.04481793
16MP0002938_white_spotting2.02295856
17MP0008057_abnormal_DNA_replication2.00372220
18MP0010307_abnormal_tumor_latency1.98289775
19MP0003635_abnormal_synaptic_transmissio1.96681695
20MP0000778_abnormal_nervous_system1.96282957
21MP0009046_muscle_twitch1.95144656
22MP0002063_abnormal_learning/memory/cond1.89235211
23MP0003890_abnormal_embryonic-extraembry1.88426633
24MP0000631_abnormal_neuroendocrine_gland1.83158372
25MP0005551_abnormal_eye_electrophysiolog1.80715059
26MP0003183_abnormal_peptide_metabolism1.79999368
27MP0000678_abnormal_parathyroid_gland1.77308145
28MP0002837_dystrophic_cardiac_calcinosis1.77266619
29MP0003718_maternal_effect1.74642352
30MP0004270_analgesia1.71662934
31MP0003111_abnormal_nucleus_morphology1.70966054
32MP0005253_abnormal_eye_physiology1.70565057
33MP0004924_abnormal_behavior1.67427996
34MP0005386_behavior/neurological_phenoty1.67427996
35MP0003693_abnormal_embryo_hatching1.66265320
36MP0010094_abnormal_chromosome_stability1.64154591
37MP0003119_abnormal_digestive_system1.63945007
38MP0002638_abnormal_pupillary_reflex1.63788569
39MP0002751_abnormal_autonomic_nervous1.61951912
40MP0005646_abnormal_pituitary_gland1.59830505
41MP0004885_abnormal_endolymph1.58991091
42MP0000372_irregular_coat_pigmentation1.57992549
43MP0002184_abnormal_innervation1.57067157
44MP0000538_abnormal_urinary_bladder1.55715966
45MP0005645_abnormal_hypothalamus_physiol1.54469301
46MP0003283_abnormal_digestive_organ1.52822262
47MP0002653_abnormal_ependyma_morphology1.51413886
48MP0003567_abnormal_fetal_cardiomyocyte1.48034033
49MP0002572_abnormal_emotion/affect_behav1.47645152
50MP0005084_abnormal_gallbladder_morpholo1.45732689
51MP0003861_abnormal_nervous_system1.44780792
52MP0001188_hyperpigmentation1.39014491
53MP0002557_abnormal_social/conspecific_i1.35781986
54MP0004147_increased_porphyrin_level1.35392629
55MP0001529_abnormal_vocalization1.33741820
56MP0008260_abnormal_autophagy1.33061439
57MP0009697_abnormal_copulation1.32268965
58MP0008872_abnormal_physiological_respon1.31420679
59MP0003880_abnormal_central_pattern1.31019863
60MP0004133_heterotaxia1.29935112
61MP0006072_abnormal_retinal_apoptosis1.27438077
62MP0008007_abnormal_cellular_replicative1.26166526
63MP0000427_abnormal_hair_cycle1.26083107
64MP0001485_abnormal_pinna_reflex1.24925523
65MP0010030_abnormal_orbit_morphology1.24493550
66MP0008995_early_reproductive_senescence1.22722942
67MP0002734_abnormal_mechanical_nocicepti1.22522982
68MP0003937_abnormal_limbs/digits/tail_de1.18834675
69MP0004145_abnormal_muscle_electrophysio1.18313640
70MP0001293_anophthalmia1.17506855
71* MP0000653_abnormal_sex_gland1.17432294
72MP0003077_abnormal_cell_cycle1.14886635
73MP0001119_abnormal_female_reproductive1.13859820
74MP0005423_abnormal_somatic_nervous1.12871304
75MP0003938_abnormal_ear_development1.12406398
76MP0004142_abnormal_muscle_tone1.12293574
77MP0002177_abnormal_outer_ear1.10927387
78MP0003699_abnormal_female_reproductive1.10454490
79MP0002249_abnormal_larynx_morphology1.09900479
80MP0003646_muscle_fatigue1.09749058
81MP0000569_abnormal_digit_pigmentation1.09584319
82MP0006036_abnormal_mitochondrial_physio1.08790551
83* MP0002210_abnormal_sex_determination1.08159594
84MP0004215_abnormal_myocardial_fiber1.07355933
85MP0006035_abnormal_mitochondrial_morpho1.07153723
86* MP0001929_abnormal_gametogenesis1.06986949
87MP0001986_abnormal_taste_sensitivity1.06358617
88MP0010386_abnormal_urinary_bladder1.04975914
89MP0002152_abnormal_brain_morphology1.04892772
90MP0001984_abnormal_olfaction1.03751610
91MP0006276_abnormal_autonomic_nervous1.02419897
92MP0004811_abnormal_neuron_physiology1.01248435
93MP0001177_atelectasis1.01056810
94MP0005075_abnormal_melanosome_morpholog1.00386460
95MP0002233_abnormal_nose_morphology1.00289463
96MP0001968_abnormal_touch/_nociception0.99532242
97MP0003786_premature_aging0.99073263
98* MP0001145_abnormal_male_reproductive0.98857317
99MP0005220_abnormal_exocrine_pancreas0.98802542
100MP0003315_abnormal_perineum_morphology0.98443352
101MP0000647_abnormal_sebaceous_gland0.96624361
102MP0008932_abnormal_embryonic_tissue0.96098855
103MP0002067_abnormal_sensory_capabilities0.95591149
104MP0001502_abnormal_circadian_rhythm0.95359377
105MP0003755_abnormal_palate_morphology0.94552211
106MP0002085_abnormal_embryonic_tissue0.94336385
107MP0002736_abnormal_nociception_after0.93523398
108MP0002822_catalepsy0.92287216
109MP0002272_abnormal_nervous_system0.91813356
110MP0005248_abnormal_Harderian_gland0.90852806
111MP0002090_abnormal_vision0.90727565
112MP0009745_abnormal_behavioral_response0.90392320
113MP0005408_hypopigmentation0.86875039
114MP0003122_maternal_imprinting0.86732867
115MP0003935_abnormal_craniofacial_develop0.86489336
116* MP0003698_abnormal_male_reproductive0.86397236
117MP0002064_seizures0.86174174
118MP0003011_delayed_dark_adaptation0.85009902
119MP0002116_abnormal_craniofacial_bone0.84669589
120MP0002882_abnormal_neuron_morphology0.84484935
121MP0005174_abnormal_tail_pigmentation0.84374329
122MP0001486_abnormal_startle_reflex0.83462096
123MP0000350_abnormal_cell_proliferation0.82705019
124* MP0002161_abnormal_fertility/fecundity0.82657738
125MP0001764_abnormal_homeostasis0.82367947
126MP0002277_abnormal_respiratory_mucosa0.82223970
127MP0005389_reproductive_system_phenotype0.81420845
128MP0002735_abnormal_chemical_nociception0.81106420
129MP0002909_abnormal_adrenal_gland0.80231000
130MP0006054_spinal_hemorrhage0.79786667
131MP0002163_abnormal_gland_morphology0.79619230
132MP0000566_synostosis0.79588892
133MP0000428_abnormal_craniofacial_morphol0.79125673
134MP0005195_abnormal_posterior_eye0.78353775
135MP0009250_abnormal_appendicular_skeleto0.78026489
136MP0005391_vision/eye_phenotype0.77762651
137MP0001970_abnormal_pain_threshold0.77218489
138MP0002084_abnormal_developmental_patter0.76739794
139MP0002160_abnormal_reproductive_system0.75961595
140MP0000049_abnormal_middle_ear0.75843583
141MP0001919_abnormal_reproductive_system0.73620537
142MP0004957_abnormal_blastocyst_morpholog0.73368720
143MP0005187_abnormal_penis_morphology0.72785558

Predicted human phenotypes

RankGene SetZ-score
1Long nose (HP:0003189)4.81601774
2Hyperventilation (HP:0002883)3.93926230
3Poor eye contact (HP:0000817)3.67677161
4Scrotal hypoplasia (HP:0000046)3.55768951
5Papillary thyroid carcinoma (HP:0002895)3.27960106
6Prominent supraorbital ridges (HP:0000336)3.03950561
7Methylmalonic aciduria (HP:0012120)3.00088770
8Posterior subcapsular cataract (HP:0007787)2.94203323
9Flat capital femoral epiphysis (HP:0003370)2.91100850
10Abnormal social behavior (HP:0012433)2.84920889
11Impaired social interactions (HP:0000735)2.84920889
12Methylmalonic acidemia (HP:0002912)2.79788540
13Fair hair (HP:0002286)2.79258699
14Medial flaring of the eyebrow (HP:0010747)2.79186412
15Abnormality of the labia minora (HP:0012880)2.74728306
16Abnormality of the metopic suture (HP:0005556)2.71924703
17Broad-based gait (HP:0002136)2.68955046
18Type 2 muscle fiber atrophy (HP:0003554)2.64974267
19Prominent metopic ridge (HP:0005487)2.64944050
20Abnormality of alanine metabolism (HP:0010916)2.55540712
21Hyperalaninemia (HP:0003348)2.55540712
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55540712
23Progressive inability to walk (HP:0002505)2.54201795
24Pancreatic fibrosis (HP:0100732)2.52858800
25Facial hemangioma (HP:0000329)2.51933337
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.51628642
27Attenuation of retinal blood vessels (HP:0007843)2.50902210
28Bifid tongue (HP:0010297)2.49672454
29Intestinal atresia (HP:0011100)2.49075659
30Gaze-evoked nystagmus (HP:0000640)2.49057584
31Excessive salivation (HP:0003781)2.47704012
32Drooling (HP:0002307)2.47704012
33Abnormality of the phalanges of the hallux (HP:0010057)2.47298281
34Supranuclear gaze palsy (HP:0000605)2.45437006
35Abolished electroretinogram (ERG) (HP:0000550)2.44354390
36Molar tooth sign on MRI (HP:0002419)2.43518907
37Abnormality of midbrain morphology (HP:0002418)2.43518907
38Male infertility (HP:0003251)2.42130897
39Volvulus (HP:0002580)2.37047618
40Abnormality of the renal medulla (HP:0100957)2.35596575
41Hypotelorism (HP:0000601)2.33428981
42Abnormality of secondary sexual hair (HP:0009888)2.31911245
43Abnormality of the axillary hair (HP:0100134)2.31911245
44Generalized hypopigmentation of hair (HP:0011358)2.30564772
45Hip contracture (HP:0003273)2.30272540
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.27796955
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27396298
48Colon cancer (HP:0003003)2.26212192
49Congenital stationary night blindness (HP:0007642)2.25468793
50Muscle fiber atrophy (HP:0100295)2.25289700
51Inability to walk (HP:0002540)2.24629471
52Acute necrotizing encephalopathy (HP:0006965)2.23762220
53Short tibia (HP:0005736)2.23649293
54Abnormality of the ileum (HP:0001549)2.23287638
55Gait imbalance (HP:0002141)2.22574921
56Hypothermia (HP:0002045)2.22265880
57Meckel diverticulum (HP:0002245)2.19278831
58Progressive macrocephaly (HP:0004481)2.19258151
59Abnormality of the wing of the ilium (HP:0011867)2.18776384
60Congenital primary aphakia (HP:0007707)2.18090054
61Postural instability (HP:0002172)2.17531725
62Abnormality of the renal cortex (HP:0011035)2.17059742
63Protruding tongue (HP:0010808)2.16354262
64Hyperglycinemia (HP:0002154)2.16202167
65Acute encephalopathy (HP:0006846)2.14687651
66Chromsome breakage (HP:0040012)2.13343536
67Absent hair (HP:0002298)2.11696269
68Enlarged penis (HP:0000040)2.10635678
69Abnormality of chromosome stability (HP:0003220)2.10503040
70Abnormality of chromosome segregation (HP:0002916)2.10124285
71Patellar aplasia (HP:0006443)2.10033256
72True hermaphroditism (HP:0010459)2.08910175
73Gastroesophageal reflux (HP:0002020)2.07106329
74Genital tract atresia (HP:0001827)2.06557649
75Midline defect of the nose (HP:0004122)2.05461759
76Supernumerary spleens (HP:0009799)2.05227145
77Nephrogenic diabetes insipidus (HP:0009806)2.04854772
78Absent speech (HP:0001344)2.01665642
79Bile duct proliferation (HP:0001408)2.00901323
80Abnormal biliary tract physiology (HP:0012439)2.00901323
81Autism (HP:0000717)1.99701215
82Hyperinsulinemic hypoglycemia (HP:0000825)1.99532786
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99321071
84Pancreatic islet-cell hyperplasia (HP:0004510)1.98111814
85Shawl scrotum (HP:0000049)1.97696743
86Nephronophthisis (HP:0000090)1.97477127
87Ketoacidosis (HP:0001993)1.96688731
88Neoplasm of the adrenal gland (HP:0100631)1.95858995
89Increased CSF lactate (HP:0002490)1.94503821
90Insomnia (HP:0100785)1.93737247
91Aplasia/Hypoplasia of the patella (HP:0006498)1.93522187
92Vaginal atresia (HP:0000148)1.93384026
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91733373
94Micropenis (HP:0000054)1.91108926
95Thin upper lip vermilion (HP:0000219)1.90342519
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90012897
97Optic nerve hypoplasia (HP:0000609)1.89395634
98Elfin facies (HP:0004428)1.88889704
99Pendular nystagmus (HP:0012043)1.88329916
100Mitochondrial inheritance (HP:0001427)1.87834846
101Abnormality of serum amino acid levels (HP:0003112)1.87037141
102Abnormality of glycine metabolism (HP:0010895)1.86873525
103Abnormality of serine family amino acid metabolism (HP:0010894)1.86873525
104Irregular vertebral endplates (HP:0003301)1.84956883
105Insulin-resistant diabetes mellitus (HP:0000831)1.84903091
106Abnormal mitochondria in muscle tissue (HP:0008316)1.84896064
107Thyroid carcinoma (HP:0002890)1.84551002
108Pancreatic cysts (HP:0001737)1.84538263
109Sclerocornea (HP:0000647)1.84109253
110Decreased central vision (HP:0007663)1.83985252
111Cystic hygroma (HP:0000476)1.83777786
112Neoplasm of the adrenal cortex (HP:0100641)1.83357460
113Truncal obesity (HP:0001956)1.81670422
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80617536
115Mild short stature (HP:0003502)1.79519513
116Congenital, generalized hypertrichosis (HP:0004540)1.78587760
117Short philtrum (HP:0000322)1.78462327
118Prominent forehead (HP:0011220)1.77856450
119Furrowed tongue (HP:0000221)1.77235518
120Hyperglycinuria (HP:0003108)1.76781063
121Absent eyebrow (HP:0002223)1.76618157
122Widely spaced teeth (HP:0000687)1.76431273
123Neurodegeneration (HP:0002180)1.76230501
124Abnormality of vitamin B metabolism (HP:0004340)1.75832732
125Metatarsus adductus (HP:0001840)1.75691014
126Deeply set eye (HP:0000490)1.75521870
127Cystic liver disease (HP:0006706)1.75445833
128Long face (HP:0000276)1.75408660
129Capillary hemangiomas (HP:0005306)1.75363083
130Abnormal rod and cone electroretinograms (HP:0008323)1.75221524
131Renal cortical cysts (HP:0000803)1.74776427
132Febrile seizures (HP:0002373)1.74593064
133Mandibular prognathia (HP:0000303)1.73347472
134Thyroid-stimulating hormone excess (HP:0002925)1.72959232
135Macrotia (HP:0000400)1.72458331
136Small hand (HP:0200055)1.71904137
137Hypoglycemic seizures (HP:0002173)1.71604769
138Hypoglycemic coma (HP:0001325)1.71160661
139Heterotopia (HP:0002282)1.70804514
140Hypoplasia of the maxilla (HP:0000327)1.70716125
141Freckling (HP:0001480)1.70442669
142Polar cataract (HP:0010696)1.70399115
143Medulloblastoma (HP:0002885)1.70155799
144Tented upper lip vermilion (HP:0010804)1.69887581
145Abnormal lung lobation (HP:0002101)1.69759478
146Glioma (HP:0009733)1.69554568
147Chronic bronchitis (HP:0004469)1.69001755
148Oligodactyly (HP:0012165)1.68975042
149Overlapping toe (HP:0001845)1.68300514
150Hypomagnesemia (HP:0002917)1.68150597
151Abnormality of the preputium (HP:0100587)1.68080224
152Abnormality of salivation (HP:0100755)1.67580102
153Increased hepatocellular lipid droplets (HP:0006565)1.67163234
154Hypoplasia of the uterus (HP:0000013)1.66626560
155Bicornuate uterus (HP:0000813)1.66539458
156Abnormality of the vitamin B12 metabolism (HP:0004341)1.66341021
157Nonprogressive disorder (HP:0003680)1.66304199
158Birth length less than 3rd percentile (HP:0003561)1.65869765
159Lipid accumulation in hepatocytes (HP:0006561)1.65830004
160Ketosis (HP:0001946)1.65376696
161Postaxial hand polydactyly (HP:0001162)1.65169165
162Duodenal stenosis (HP:0100867)1.65050572
163Small intestinal stenosis (HP:0012848)1.65050572
164Subcapsular cataract (HP:0000523)1.64507774
165Aplasia/hypoplasia of the uterus (HP:0008684)1.64416783
166Optic disc pallor (HP:0000543)1.64217587
167Male pseudohermaphroditism (HP:0000037)1.64043311
168Stomach cancer (HP:0012126)1.63986127
169Gonadotropin excess (HP:0000837)1.63798005
170Dandy-Walker malformation (HP:0001305)1.63497421
171Abnormality of the intervertebral disk (HP:0005108)1.62578343
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.62393251
173Megalocornea (HP:0000485)1.61282082
174Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.60599221
175Hyperglycemia (HP:0003074)1.59548224
176Optic nerve coloboma (HP:0000588)1.59026306
177Brachycephaly (HP:0000248)1.58995189
178Generalized hyperpigmentation (HP:0007440)1.58825713
179Aplasia/Hypoplasia of the sternum (HP:0006714)1.58666642
180Focal motor seizures (HP:0011153)1.57872283
181Aplastic anemia (HP:0001915)1.56833897
182Aplasia/Hypoplasia of the brainstem (HP:0007362)1.55199323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.32837697
2NTRK33.73060712
3LATS13.21827777
4TRIM283.13321103
5MUSK3.11994298
6KSR12.75240509
7PLK42.75066772
8NUAK12.67516891
9KSR22.62342161
10CDK32.56913825
11MAP4K22.54770163
12ZAK2.44200885
13MARK12.42471916
14LATS22.33952545
15MAP3K92.24943147
16BRAF2.21144171
17MAP3K62.19912533
18MAPK132.14322533
19EPHA42.11284095
20SRPK12.00096159
21MAP3K41.99024919
22BCR1.92614108
23EEF2K1.82180091
24EIF2AK31.81615553
25PAK61.81045444
26INSRR1.77241277
27ERBB41.76937422
28CDC71.58428853
29GRK11.54981321
30TGFBR11.52304877
31RAF11.52260583
32BMPR1B1.52063285
33MAP2K71.49805300
34ADRBK21.47885573
35MAP3K101.43156144
36WNK31.43140304
37TAOK11.41901444
38NEK11.39575925
39MST41.39212124
40MAPKAPK51.37175066
41TTK1.36798224
42STK38L1.35947189
43CHEK21.34611659
44NTRK21.33483849
45TNIK1.28007066
46DYRK21.27926814
47BRSK21.26806528
48TAOK31.25684931
49TLK11.22921747
50PRKD31.22583740
51SGK21.21646756
52AKT31.18679991
53CDK81.18396796
54PLK31.16917803
55MAP3K131.14100493
56STK31.06601440
57BRSK11.01696797
58DYRK1A1.01540651
59PINK11.00767978
60MINK11.00042105
61BCKDK0.98919939
62NEK20.93261108
63ACVR1B0.93220951
64PLK10.92855532
65BRD40.91762081
66BMPR20.91189372
67WEE10.90016374
68TSSK60.88448800
69SGK4940.88179906
70SGK2230.88179906
71PASK0.87569412
72OXSR10.87494068
73MAP2K40.86188429
74ARAF0.80973844
75VRK20.79485240
76PRKCE0.76495115
77MARK20.75793711
78TAF10.74230277
79CSNK1G20.72019572
80PNCK0.71037722
81MAPKAPK30.70635745
82EIF2AK10.70176207
83PRKCG0.69350705
84EIF2AK20.68900584
85STK160.68880147
86CDK190.68313978
87VRK10.66022629
88CAMKK20.65122321
89CCNB10.64047117
90FLT30.63255790
91PLK20.62937770
92ERBB30.61170048
93FGFR20.60980517
94STK390.60884109
95CASK0.60679605
96STK240.59474216
97TEC0.59141276
98PRKAA10.58623579
99PHKG20.56356876
100PHKG10.56356876
101PBK0.56035230
102HIPK20.54063935
103SGK30.53981666
104UHMK10.53605231
105CHEK10.53413406
106DAPK20.53388643
107CSNK1G30.53347640
108MELK0.53158742
109CDK90.52298307
110MKNK20.52224538
111OBSCN0.51399390
112CSNK1A1L0.49945085
113ATR0.48396927
114MOS0.47915210
115PAK30.47793837
116CAMK2A0.47449845
117RET0.45983598
118CSNK1D0.45934176
119MAPK110.45382493
120MAP3K50.45242336
121ADRBK10.43741790
122CSNK1G10.42432799
123DYRK30.42114130
124MKNK10.42082090
125BUB10.42047779
126ATM0.41828742
127RPS6KA40.41628382
128IRAK20.41624753
129TIE10.41482621
130TAOK20.41026634
131CDK10.39927448
132RPS6KA50.39631815
133RPS6KA20.39026100
134RPS6KB20.38477060
135LIMK10.38243369
136FER0.38137286
137AURKB0.36961206
138CDK20.36880246
139STK380.35595627
140MAPK100.33676701
141CSNK1A10.33644128
142DAPK10.32828261
143PKN10.32054324
144YES10.31443662
145CSNK2A10.30161138
146PRKACA0.26509504

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.23799644
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.90026968
3Propanoate metabolism_Homo sapiens_hsa006402.71822093
4Proteasome_Homo sapiens_hsa030502.55879564
5Cell cycle_Homo sapiens_hsa041102.51996193
6Non-homologous end-joining_Homo sapiens_hsa034502.38554040
7Butanoate metabolism_Homo sapiens_hsa006502.26621320
8Circadian rhythm_Homo sapiens_hsa047102.23939820
9Basal transcription factors_Homo sapiens_hsa030222.21555385
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.21293121
11* RNA degradation_Homo sapiens_hsa030182.16018715
12Oocyte meiosis_Homo sapiens_hsa041142.12430580
13Ovarian steroidogenesis_Homo sapiens_hsa049132.11962971
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03049455
15Phototransduction_Homo sapiens_hsa047441.98645534
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95730710
17Long-term potentiation_Homo sapiens_hsa047201.92076257
18Nicotine addiction_Homo sapiens_hsa050331.88881317
19Oxidative phosphorylation_Homo sapiens_hsa001901.83799733
20Glutamatergic synapse_Homo sapiens_hsa047241.78466103
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70838747
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70242189
23Colorectal cancer_Homo sapiens_hsa052101.68988383
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67935495
25Olfactory transduction_Homo sapiens_hsa047401.67383755
26Insulin secretion_Homo sapiens_hsa049111.65787299
27GnRH signaling pathway_Homo sapiens_hsa049121.62808274
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62704541
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61170171
30Circadian entrainment_Homo sapiens_hsa047131.60703507
31Amphetamine addiction_Homo sapiens_hsa050311.58695885
32Selenocompound metabolism_Homo sapiens_hsa004501.56828536
33Dopaminergic synapse_Homo sapiens_hsa047281.50994110
34Morphine addiction_Homo sapiens_hsa050321.49701281
35Steroid biosynthesis_Homo sapiens_hsa001001.48519745
36Serotonergic synapse_Homo sapiens_hsa047261.48237097
37Parkinsons disease_Homo sapiens_hsa050121.48164085
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47108152
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39791604
40Nitrogen metabolism_Homo sapiens_hsa009101.39642200
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.38467317
42RNA transport_Homo sapiens_hsa030131.34993909
43Long-term depression_Homo sapiens_hsa047301.34498071
44Cholinergic synapse_Homo sapiens_hsa047251.32942877
45Base excision repair_Homo sapiens_hsa034101.32705897
46Cocaine addiction_Homo sapiens_hsa050301.31356522
47Taste transduction_Homo sapiens_hsa047421.26942246
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25155826
49GABAergic synapse_Homo sapiens_hsa047271.24481096
50One carbon pool by folate_Homo sapiens_hsa006701.24372904
51Mismatch repair_Homo sapiens_hsa034301.20553293
52mRNA surveillance pathway_Homo sapiens_hsa030151.18159873
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.16051286
54Axon guidance_Homo sapiens_hsa043601.14723733
55Endometrial cancer_Homo sapiens_hsa052131.14206602
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13509811
57Peroxisome_Homo sapiens_hsa041461.11106492
58Pancreatic cancer_Homo sapiens_hsa052121.10923602
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10448475
60Pyrimidine metabolism_Homo sapiens_hsa002401.10232205
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08480246
62Tryptophan metabolism_Homo sapiens_hsa003801.07610674
63Inositol phosphate metabolism_Homo sapiens_hsa005621.05354941
64Fanconi anemia pathway_Homo sapiens_hsa034601.05349978
65FoxO signaling pathway_Homo sapiens_hsa040681.05188210
66Prolactin signaling pathway_Homo sapiens_hsa049171.05002558
67Caffeine metabolism_Homo sapiens_hsa002321.03851852
68Fatty acid elongation_Homo sapiens_hsa000621.03222238
69Regulation of autophagy_Homo sapiens_hsa041401.02734316
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00528656
71Huntingtons disease_Homo sapiens_hsa050160.99030094
72Synaptic vesicle cycle_Homo sapiens_hsa047210.98420320
73Oxytocin signaling pathway_Homo sapiens_hsa049210.98236092
74p53 signaling pathway_Homo sapiens_hsa041150.97472292
75DNA replication_Homo sapiens_hsa030300.97045986
76cAMP signaling pathway_Homo sapiens_hsa040240.95802529
77Choline metabolism in cancer_Homo sapiens_hsa052310.95735063
78Nucleotide excision repair_Homo sapiens_hsa034200.95414221
79Glioma_Homo sapiens_hsa052140.94781169
80TGF-beta signaling pathway_Homo sapiens_hsa043500.94604819
81Estrogen signaling pathway_Homo sapiens_hsa049150.91878872
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91876003
83VEGF signaling pathway_Homo sapiens_hsa043700.90657489
84ErbB signaling pathway_Homo sapiens_hsa040120.90549956
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89674253
86Gap junction_Homo sapiens_hsa045400.88247713
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87807636
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.87064556
89Homologous recombination_Homo sapiens_hsa034400.86574769
90Hippo signaling pathway_Homo sapiens_hsa043900.86498075
91Alzheimers disease_Homo sapiens_hsa050100.85567670
92Ether lipid metabolism_Homo sapiens_hsa005650.85491968
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82416500
94Type II diabetes mellitus_Homo sapiens_hsa049300.81664327
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79837413
96Wnt signaling pathway_Homo sapiens_hsa043100.79477412
97Gastric acid secretion_Homo sapiens_hsa049710.79214910
98mTOR signaling pathway_Homo sapiens_hsa041500.78459495
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77264689
100beta-Alanine metabolism_Homo sapiens_hsa004100.76472162
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76150197
102MAPK signaling pathway_Homo sapiens_hsa040100.76087686
103Pyruvate metabolism_Homo sapiens_hsa006200.74913279
104MicroRNAs in cancer_Homo sapiens_hsa052060.73584442
105Renal cell carcinoma_Homo sapiens_hsa052110.73498870
106Ras signaling pathway_Homo sapiens_hsa040140.72461813
107Non-small cell lung cancer_Homo sapiens_hsa052230.72279684
108Dorso-ventral axis formation_Homo sapiens_hsa043200.72251166
109Purine metabolism_Homo sapiens_hsa002300.70849129
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70752607
111Hedgehog signaling pathway_Homo sapiens_hsa043400.70654759
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70525606
113Adherens junction_Homo sapiens_hsa045200.69511571
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69093406
115Thyroid cancer_Homo sapiens_hsa052160.67850013
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67798295
117Alcoholism_Homo sapiens_hsa050340.66782149
118Melanogenesis_Homo sapiens_hsa049160.66306928
119Melanoma_Homo sapiens_hsa052180.66208794
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66205478
121Spliceosome_Homo sapiens_hsa030400.65814043
122Metabolic pathways_Homo sapiens_hsa011000.65475693
123Salivary secretion_Homo sapiens_hsa049700.64666784
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64549472
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64481558
126Sulfur metabolism_Homo sapiens_hsa009200.63709933
127N-Glycan biosynthesis_Homo sapiens_hsa005100.63462491
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63074520
129Cardiac muscle contraction_Homo sapiens_hsa042600.59878369
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.59822007
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59781190
132HTLV-I infection_Homo sapiens_hsa051660.58901729
133Vitamin B6 metabolism_Homo sapiens_hsa007500.57634564
134Rap1 signaling pathway_Homo sapiens_hsa040150.57603739
135Fatty acid metabolism_Homo sapiens_hsa012120.57204134
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.56992483
137Type I diabetes mellitus_Homo sapiens_hsa049400.56771679
138Retinol metabolism_Homo sapiens_hsa008300.56473023
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55625617
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.53939130
141RNA polymerase_Homo sapiens_hsa030200.53839367
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.53825635
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52464734
144Calcium signaling pathway_Homo sapiens_hsa040200.52179457
145Linoleic acid metabolism_Homo sapiens_hsa005910.51795803
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51657437
147Renin secretion_Homo sapiens_hsa049240.50982175
148Folate biosynthesis_Homo sapiens_hsa007900.48007027
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46817215
150Collecting duct acid secretion_Homo sapiens_hsa049660.46563078
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44993033
152Arachidonic acid metabolism_Homo sapiens_hsa005900.44159515
153Chemical carcinogenesis_Homo sapiens_hsa052040.43822273
154Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43207957
155Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42571692
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42288929
157Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42262518
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41030143
159Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39598872
160Fatty acid degradation_Homo sapiens_hsa000710.39020505
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33042011
162Vitamin digestion and absorption_Homo sapiens_hsa049770.29100028

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