CNOT7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.32884061
2Arp2/3 complex-mediated actin nucleation (GO:0034314)5.93926781
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.71516153
4cytidine metabolic process (GO:0046087)5.68274238
5cytidine catabolic process (GO:0006216)5.68274238
6cytidine deamination (GO:0009972)5.68274238
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.51933368
8actin nucleation (GO:0045010)5.25937594
9sequestering of actin monomers (GO:0042989)5.01422263
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.80235909
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63709668
12ATP synthesis coupled proton transport (GO:0015986)4.63709668
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.55366647
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.49891291
15proteasome assembly (GO:0043248)4.49556662
16regulation of T cell tolerance induction (GO:0002664)4.37634370
17regulation of cellular amino acid metabolic process (GO:0006521)4.25635848
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.14858549
19respiratory electron transport chain (GO:0022904)4.13570562
20platelet dense granule organization (GO:0060155)4.13035061
21antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.07441360
22electron transport chain (GO:0022900)4.03089160
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.97749241
24regulation of tolerance induction (GO:0002643)3.88654883
25positive regulation of tolerance induction (GO:0002645)3.87007352
26positive regulation of interleukin-8 secretion (GO:2000484)3.84107330
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.80413547
28immunoglobulin mediated immune response (GO:0016064)3.72583001
29regulation of interleukin-8 secretion (GO:2000482)3.71433658
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.69552166
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.67915747
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.67915747
33cytolysis (GO:0019835)3.67513043
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.63453593
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.63453593
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.63453593
37positive thymic T cell selection (GO:0045059)3.62499800
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.61238362
39positive T cell selection (GO:0043368)3.59920720
40negative regulation of ligase activity (GO:0051352)3.53720296
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.53720296
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46010474
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.46010474
44T cell costimulation (GO:0031295)3.44099297
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.43831609
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42144064
47T cell migration (GO:0072678)3.40661998
48lymphocyte costimulation (GO:0031294)3.40299022
49respiratory chain complex IV assembly (GO:0008535)3.35463057
50protein neddylation (GO:0045116)3.33069966
51antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.30856489
52positive regulation of lamellipodium assembly (GO:0010592)3.29417155
53B cell mediated immunity (GO:0019724)3.27409404
54negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25470640
55deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.22161673
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.19944686
57positive regulation of T cell mediated cytotoxicity (GO:0001916)3.19103094
58T cell receptor signaling pathway (GO:0050852)3.18796075
59GPI anchor biosynthetic process (GO:0006506)3.15142865
60positive regulation of calcium-mediated signaling (GO:0050850)3.14584279
61purine deoxyribonucleotide catabolic process (GO:0009155)3.12524548
62positive regulation of interleukin-1 beta secretion (GO:0050718)3.12388599
63positive regulation of interleukin-4 production (GO:0032753)3.10385415
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08303762
65positive regulation of monocyte chemotaxis (GO:0090026)3.06631405
66negative regulation of T cell apoptotic process (GO:0070233)3.06464408
67regulation of cellular amine metabolic process (GO:0033238)3.05839568
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03796408
69positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.02906339
70cellular response to interleukin-15 (GO:0071350)3.02302010
71positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.02118021
72regulation of alpha-beta T cell proliferation (GO:0046640)2.99620972
73negative T cell selection (GO:0043383)2.99503412
74mast cell activation (GO:0045576)2.98956445
75positive regulation of interleukin-1 secretion (GO:0050716)2.95102809
76positive regulation of ligase activity (GO:0051351)2.93418165
77GPI anchor metabolic process (GO:0006505)2.87707825
78response to interferon-beta (GO:0035456)2.85937106
79pyrimidine nucleoside catabolic process (GO:0046135)2.85438779
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84904579
81negative regulation of stress fiber assembly (GO:0051497)2.84857333
82regulation of interleukin-1 beta secretion (GO:0050706)2.84166595
83production of molecular mediator involved in inflammatory response (GO:0002532)2.83774247
84cytochrome complex assembly (GO:0017004)2.83608536
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.82795223
86termination of RNA polymerase III transcription (GO:0006386)2.82795223
87regulation of T cell mediated cytotoxicity (GO:0001914)2.82271752
88positive regulation of cell cycle arrest (GO:0071158)2.80238541
89regulation of regulatory T cell differentiation (GO:0045589)2.80051697
90regulation of interleukin-2 biosynthetic process (GO:0045076)2.75940435
91hydrogen ion transmembrane transport (GO:1902600)2.74504377
92cell wall macromolecule metabolic process (GO:0044036)2.72986504
93deoxyribonucleotide catabolic process (GO:0009264)2.70104351
94regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67808783
95ribosomal small subunit assembly (GO:0000028)2.66883243
96antigen receptor-mediated signaling pathway (GO:0050851)2.65428877
97regulation of cellular respiration (GO:0043457)2.65095972
98positive regulation of cell killing (GO:0031343)2.63478847
99positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.63387714
100positive regulation of lamellipodium organization (GO:1902745)2.62805092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.98542529
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.70791048
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.88959852
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.52107799
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29506725
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99439136
7VDR_22108803_ChIP-Seq_LS180_Human2.99272587
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93510212
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.93156137
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.83444193
11EZH2_22144423_ChIP-Seq_EOC_Human2.77027375
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.75709354
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73451433
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.61867922
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.53922787
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50918390
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41694416
18VDR_23849224_ChIP-Seq_CD4+_Human2.16695309
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11585612
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06594552
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99570972
22IGF1R_20145208_ChIP-Seq_DFB_Human1.97457366
23MYB_26560356_Chip-Seq_TH2_Human1.95167506
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75481279
25ELK1_19687146_ChIP-ChIP_HELA_Human1.69330648
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69189045
27GATA3_26560356_Chip-Seq_TH2_Human1.66944511
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.65647853
29ZNF274_21170338_ChIP-Seq_K562_Hela1.62306524
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.58821020
31CIITA_25753668_ChIP-Seq_RAJI_Human1.53411233
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50982012
33TAF15_26573619_Chip-Seq_HEK293_Human1.50047000
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48399620
35EWS_26573619_Chip-Seq_HEK293_Human1.46842927
36FOXP3_21729870_ChIP-Seq_TREG_Human1.41980810
37AR_20517297_ChIP-Seq_VCAP_Human1.39021969
38TP53_22573176_ChIP-Seq_HFKS_Human1.35768287
39PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.34136864
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32665066
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31798022
42GATA3_27048872_Chip-Seq_THYMUS_Human1.31074694
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30335354
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28072908
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.25915470
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25915470
47SPI1_23547873_ChIP-Seq_NB4_Human1.25667533
48HTT_18923047_ChIP-ChIP_STHdh_Human1.25533272
49RUNX_20019798_ChIP-Seq_JUKART_Human1.25067722
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.24549476
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.24031176
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23493896
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22441078
54SOX2_19829295_ChIP-Seq_ESCs_Human1.20775580
55NANOG_19829295_ChIP-Seq_ESCs_Human1.20775580
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19744023
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17933537
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15615321
59CBP_20019798_ChIP-Seq_JUKART_Human1.15615321
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14798072
61ERG_20517297_ChIP-Seq_VCAP_Human1.14466296
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.13444561
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13434172
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13432942
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11399797
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10783027
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10534834
68GBX2_23144817_ChIP-Seq_PC3_Human1.08716320
69MYB_26560356_Chip-Seq_TH1_Human1.07835696
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07141874
71NCOR_22424771_ChIP-Seq_293T_Human1.06998922
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.06937955
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04061926
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03210390
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02163832
76GATA3_26560356_Chip-Seq_TH1_Human1.01840011
77TAF2_19829295_ChIP-Seq_ESCs_Human1.01044913
78P300_19829295_ChIP-Seq_ESCs_Human1.00725634
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00115188
80MYC_19829295_ChIP-Seq_ESCs_Human0.99730697
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98868341
82ER_23166858_ChIP-Seq_MCF-7_Human0.98690414
83NANOG_20526341_ChIP-Seq_ESCs_Human0.97078763
84TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96712827
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95822721
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93483139
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93437505
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93234948
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93044584
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92645328
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92217037
92SCL_19346495_ChIP-Seq_HPC-7_Human0.91669569
93GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90782110
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90698465
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89639177
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89458800
97FUS_26573619_Chip-Seq_HEK293_Human0.88309817
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86871955
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.86337050
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.86145520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.01672584
2MP0001835_abnormal_antigen_presentation4.51982578
3MP0002166_altered_tumor_susceptibility3.59585501
4MP0009785_altered_susceptibility_to3.22333195
5MP0009333_abnormal_splenocyte_physiolog3.17483316
6MP0002006_tumorigenesis2.87205579
7MP0005000_abnormal_immune_tolerance2.62578325
8MP0003806_abnormal_nucleotide_metabolis2.61005958
9MP0006072_abnormal_retinal_apoptosis2.32057523
10MP0001800_abnormal_humoral_immune2.21164686
11MP0002102_abnormal_ear_morphology2.15361479
12MP0005025_abnormal_response_to2.08333415
13MP0002723_abnormal_immune_serum2.04681626
14MP0003763_abnormal_thymus_physiology2.03903170
15MP0002420_abnormal_adaptive_immunity2.02911622
16MP0001819_abnormal_immune_cell1.99084642
17MP0009764_decreased_sensitivity_to1.98424227
18MP0003866_abnormal_defecation1.94808235
19MP0006082_CNS_inflammation1.91926036
20MP0003195_calcinosis1.91494800
21MP0008872_abnormal_physiological_respon1.86375680
22MP0002452_abnormal_antigen_presenting1.85244095
23MP0005646_abnormal_pituitary_gland1.82520927
24MP0002148_abnormal_hypersensitivity_rea1.77840109
25MP0001905_abnormal_dopamine_level1.75545970
26MP0001919_abnormal_reproductive_system1.69594594
27MP0010155_abnormal_intestine_physiology1.64236761
28MP0003724_increased_susceptibility_to1.58471753
29MP0009379_abnormal_foot_pigmentation1.56233453
30MP0003787_abnormal_imprinting1.53370438
31MP0001845_abnormal_inflammatory_respons1.49518888
32MP0000716_abnormal_immune_system1.44866231
33MP0005387_immune_system_phenotype1.41255595
34MP0001790_abnormal_immune_system1.41255595
35MP0001529_abnormal_vocalization1.40941466
36MP0002419_abnormal_innate_immunity1.39879362
37MP0005464_abnormal_platelet_physiology1.36908135
38MP0005645_abnormal_hypothalamus_physiol1.32668347
39MP0003646_muscle_fatigue1.32397724
40MP0002398_abnormal_bone_marrow1.31851057
41MP0005253_abnormal_eye_physiology1.31844042
42MP0000372_irregular_coat_pigmentation1.29856007
43MP0000685_abnormal_immune_system1.28911216
44MP0005389_reproductive_system_phenotype1.26500168
45MP0001765_abnormal_ion_homeostasis1.26078751
46MP0003436_decreased_susceptibility_to1.25248523
47MP0005551_abnormal_eye_electrophysiolog1.22696054
48MP0004147_increased_porphyrin_level1.21832733
49MP0001873_stomach_inflammation1.21296655
50MP0008877_abnormal_DNA_methylation1.20373815
51MP0009697_abnormal_copulation1.19468913
52MP0008995_early_reproductive_senescence1.17857695
53MP0006036_abnormal_mitochondrial_physio1.16675712
54MP0004145_abnormal_muscle_electrophysio1.16657002
55MP0003448_altered_tumor_morphology1.13132789
56MP0003880_abnormal_central_pattern1.12484628
57MP0005636_abnormal_mineral_homeostasis1.09800678
58MP0009763_increased_sensitivity_to1.08177046
59MP0002837_dystrophic_cardiac_calcinosis1.07943644
60MP0002405_respiratory_system_inflammati1.07525261
61MP0005367_renal/urinary_system_phenotyp1.05787696
62MP0000516_abnormal_urinary_system1.05787696
63MP0001764_abnormal_homeostasis1.05656521
64MP0008875_abnormal_xenobiotic_pharmacok1.05492146
65MP0008469_abnormal_protein_level1.04972146
66MP0002429_abnormal_blood_cell1.04816369
67MP0000689_abnormal_spleen_morphology1.04147056
68MP0005166_decreased_susceptibility_to1.01735785
69MP0005075_abnormal_melanosome_morpholog0.99756133
70MP0002138_abnormal_hepatobiliary_system0.99624554
71MP0002722_abnormal_immune_system0.99275684
72MP0002163_abnormal_gland_morphology0.97390641
73MP0002822_catalepsy0.89792779
74MP0000639_abnormal_adrenal_gland0.88016164
75MP0002933_joint_inflammation0.86408245
76MP0003786_premature_aging0.84823873
77MP0002277_abnormal_respiratory_mucosa0.84695351
78MP0000858_altered_metastatic_potential0.83830976
79MP0000703_abnormal_thymus_morphology0.83043768
80MP0005084_abnormal_gallbladder_morpholo0.80913197
81MP0001968_abnormal_touch/_nociception0.75899477
82MP0001661_extended_life_span0.75836278
83MP0002095_abnormal_skin_pigmentation0.73510122
84MP0004947_skin_inflammation0.73366731
85MP0003638_abnormal_response/metabolism_0.73069092
86MP0003075_altered_response_to0.73056835
87MP0010386_abnormal_urinary_bladder0.72969391
88MP0005085_abnormal_gallbladder_physiolo0.72708636
89MP0006276_abnormal_autonomic_nervous0.68906376
90MP0001485_abnormal_pinna_reflex0.68815021
91MP0001970_abnormal_pain_threshold0.68124600
92MP0009745_abnormal_behavioral_response0.65704986
93MP0001119_abnormal_female_reproductive0.64329667
94MP0003252_abnormal_bile_duct0.63036464
95MP0002019_abnormal_tumor_incidence0.62898881
96MP0002693_abnormal_pancreas_physiology0.62143981
97MP0002272_abnormal_nervous_system0.59051977
98MP0003137_abnormal_impulse_conducting0.58104107
99MP0001486_abnormal_startle_reflex0.57615721
100MP0009046_muscle_twitch0.57348157

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.66715440
2Acute necrotizing encephalopathy (HP:0006965)4.45658848
3Aplastic anemia (HP:0001915)4.32353331
4Hepatocellular necrosis (HP:0001404)4.30525494
5Abnormal mitochondria in muscle tissue (HP:0008316)4.01051594
6Progressive macrocephaly (HP:0004481)3.87238673
7Increased CSF lactate (HP:0002490)3.81132727
8Hepatic necrosis (HP:0002605)3.80907199
9T lymphocytopenia (HP:0005403)3.79610925
10Hypoproteinemia (HP:0003075)3.74021819
11Severe combined immunodeficiency (HP:0004430)3.66416993
12Acute encephalopathy (HP:0006846)3.58280442
13Abnormality of T cell number (HP:0011839)3.54261282
14Elevated erythrocyte sedimentation rate (HP:0003565)3.46500574
15Increased hepatocellular lipid droplets (HP:0006565)3.24590887
16IgG deficiency (HP:0004315)3.22758074
17Congenital, generalized hypertrichosis (HP:0004540)3.20911173
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.15278897
19Cerebral edema (HP:0002181)3.14498004
20Type I transferrin isoform profile (HP:0003642)3.05019774
21Abnormality of the prostate (HP:0008775)3.01921723
22Decreased electroretinogram (ERG) amplitude (HP:0000654)3.00054260
23Thyroiditis (HP:0100646)2.99319393
24Lipid accumulation in hepatocytes (HP:0006561)2.90439529
25Increased intramyocellular lipid droplets (HP:0012240)2.86251610
26Hypothermia (HP:0002045)2.83019959
27Renal Fanconi syndrome (HP:0001994)2.81933301
28Combined immunodeficiency (HP:0005387)2.74269568
29Abnormality of eosinophils (HP:0001879)2.73983326
30Attenuation of retinal blood vessels (HP:0007843)2.73553997
31Abolished electroretinogram (ERG) (HP:0000550)2.73255097
32Exertional dyspnea (HP:0002875)2.72926799
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66321394
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66321394
35B lymphocytopenia (HP:0010976)2.60153451
36Severe visual impairment (HP:0001141)2.55983527
37Abnormality of B cell number (HP:0010975)2.55548823
38Decreased central vision (HP:0007663)2.51807428
39Pancreatic cysts (HP:0001737)2.50579671
40Tetany (HP:0001281)2.48897588
41Eosinophilia (HP:0001880)2.46981199
42Lactic acidosis (HP:0003128)2.43396785
43Increased serum lactate (HP:0002151)2.41701840
44Optic disc pallor (HP:0000543)2.38170063
45Increased muscle lipid content (HP:0009058)2.37208228
46Autoimmune hemolytic anemia (HP:0001890)2.36646137
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35364525
48Abnormal protein N-linked glycosylation (HP:0012347)2.35364525
49Abnormal protein glycosylation (HP:0012346)2.35364525
50Abnormal glycosylation (HP:0012345)2.35364525
51Abnormal albumin level (HP:0012116)2.34391677
52Hypoalbuminemia (HP:0003073)2.34391677
53Generalized aminoaciduria (HP:0002909)2.33942852
54Alveolar cell carcinoma (HP:0006519)2.33347854
55Congenital stationary night blindness (HP:0007642)2.33289431
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33192869
57Abnormal rod and cone electroretinograms (HP:0008323)2.28473058
58Microretrognathia (HP:0000308)2.22372129
59Abnormality of T cells (HP:0002843)2.18310886
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16620045
61Leukocytosis (HP:0001974)2.15372831
62Chronic diarrhea (HP:0002028)2.12474825
63Leukodystrophy (HP:0002415)2.12330217
64Increased IgM level (HP:0003496)2.11323726
65Neoplasm of the tracheobronchial system (HP:0100552)2.07633366
66Respiratory failure (HP:0002878)2.05974411
67True hermaphroditism (HP:0010459)2.03256347
68Exercise intolerance (HP:0003546)1.97401831
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.93502959
70Radial bowing (HP:0002986)1.93201839
71Hypomagnesemia (HP:0002917)1.93009419
723-Methylglutaconic aciduria (HP:0003535)1.91907010
73Split foot (HP:0001839)1.90257458
74Reduced antithrombin III activity (HP:0001976)1.89281257
75Pustule (HP:0200039)1.88989965
76Short tibia (HP:0005736)1.88012726
77Encephalitis (HP:0002383)1.87161631
78Granulocytopenia (HP:0001913)1.86984414
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85710483
80Abnormality of alanine metabolism (HP:0010916)1.85710483
81Hyperalaninemia (HP:0003348)1.85710483
82Conjunctival hamartoma (HP:0100780)1.84184410
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.83186164
84Abnormality of the axillary hair (HP:0100134)1.83046685
85Abnormality of secondary sexual hair (HP:0009888)1.83046685
86Keratoconjunctivitis (HP:0001096)1.82954668
87Lethargy (HP:0001254)1.81010760
88Myositis (HP:0100614)1.79967277
89Respiratory difficulties (HP:0002880)1.78061865
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76036007
91Stomatitis (HP:0010280)1.73529014
92Recurrent abscess formation (HP:0002722)1.72363812
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.71693366
94Pancreatic fibrosis (HP:0100732)1.71338033
95Abnormal drinking behavior (HP:0030082)1.71129234
96Polydipsia (HP:0001959)1.71129234
97Abnormality of midbrain morphology (HP:0002418)1.71083189
98Molar tooth sign on MRI (HP:0002419)1.71083189
99Cerebral palsy (HP:0100021)1.69967309
100Abnormality of magnesium homeostasis (HP:0004921)1.69177119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.20686884
2TESK24.36127400
3BCKDK4.26521742
4MAP3K124.17448186
5TESK12.55791605
6TXK2.40428797
7TAOK32.38124613
8MYLK2.36307877
9BMPR22.25061332
10TLK12.12197520
11MAP4K12.10145450
12LIMK12.07348142
13GRK62.04115496
14MST41.88714287
15ERBB31.70486697
16STK161.69046263
17VRK21.66527515
18ZAK1.64759778
19TEC1.64280916
20ITK1.63202932
21CDK191.58774302
22NUAK11.54591046
23RPS6KA41.48114159
24CSF1R1.39951629
25VRK11.38518705
26MAP4K21.37278327
27RIPK41.32037729
28PIK3CG1.27285322
29SYK1.25299112
30ADRBK21.24237578
31DAPK11.23710445
32BTK1.23148144
33CSNK1G31.14375997
34BUB11.11675564
35TNK21.10010142
36ILK1.05709166
37GRK11.05033338
38LCK0.98931572
39CSNK1G20.98049982
40TRPM70.98019277
41EIF2AK30.97271776
42LYN0.97215836
43FRK0.94946058
44CSNK1A1L0.93397345
45TIE10.93313725
46RPS6KA50.93240330
47PRKCQ0.89459116
48INSRR0.89234628
49KIT0.85399287
50BCR0.85075337
51DAPK30.83032963
52CSNK1G10.80410019
53GRK70.77249572
54SCYL20.76635698
55TRIM280.76613268
56ZAP700.74271434
57IKBKE0.73879222
58IKBKB0.73218509
59WNK30.73168060
60PRKCE0.69515966
61OBSCN0.67388470
62ROCK10.66041386
63FES0.65676585
64MUSK0.62558754
65MAPK130.61457771
66CAMKK20.57026250
67IGF1R0.56350131
68CLK10.56082963
69DYRK20.55696990
70PKN10.53307415
71PRKG20.50805265
72EGFR0.50793233
73JAK30.50661715
74OXSR10.50357630
75CSK0.49515937
76NME20.47745184
77ABL10.42523989
78HCK0.41878150
79ADRBK10.41027292
80PAK10.40836686
81PIM10.40590256
82PAK40.38303294
83PRKACA0.38133333
84PRKCA0.37197575
85PIK3CA0.36827822
86TBK10.36178040
87INSR0.32311692
88FLT30.31938239
89PLK40.30599494
90CDK80.29984634
91FYN0.29791309
92PRKG10.28709534
93CSNK2A10.27975657
94CAMK2G0.27622134
95ABL20.27355839
96SRPK10.27323033
97AURKB0.27199993
98MAP2K70.26113557
99CSNK2A20.25934052
100SIK30.25207875

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.72585334
2Graft-versus-host disease_Homo sapiens_hsa053324.04281556
3Allograft rejection_Homo sapiens_hsa053303.85359945
4Asthma_Homo sapiens_hsa053103.77690726
5Autoimmune thyroid disease_Homo sapiens_hsa053203.74774906
6Oxidative phosphorylation_Homo sapiens_hsa001903.49524606
7Type I diabetes mellitus_Homo sapiens_hsa049403.30330199
8Primary immunodeficiency_Homo sapiens_hsa053403.01872968
9Antigen processing and presentation_Homo sapiens_hsa046122.86857901
10Parkinsons disease_Homo sapiens_hsa050122.83705240
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.64227201
12Protein export_Homo sapiens_hsa030602.47262666
13RNA polymerase_Homo sapiens_hsa030202.23318057
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04297219
15Viral myocarditis_Homo sapiens_hsa054162.00127306
16Alzheimers disease_Homo sapiens_hsa050101.92410380
17Ribosome_Homo sapiens_hsa030101.92032669
18Rheumatoid arthritis_Homo sapiens_hsa053231.87335573
19Huntingtons disease_Homo sapiens_hsa050161.76915093
20Hematopoietic cell lineage_Homo sapiens_hsa046401.71965621
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69572738
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67367402
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53822470
24Cardiac muscle contraction_Homo sapiens_hsa042601.43264910
25Staphylococcus aureus infection_Homo sapiens_hsa051501.42016572
26Phototransduction_Homo sapiens_hsa047441.41203328
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29449446
28Nitrogen metabolism_Homo sapiens_hsa009101.16956095
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14491430
30Systemic lupus erythematosus_Homo sapiens_hsa053221.10770205
31Collecting duct acid secretion_Homo sapiens_hsa049661.01537316
32Leishmaniasis_Homo sapiens_hsa051400.96964672
33T cell receptor signaling pathway_Homo sapiens_hsa046600.93914134
34Salmonella infection_Homo sapiens_hsa051320.75523485
35Pyrimidine metabolism_Homo sapiens_hsa002400.74587600
36Shigellosis_Homo sapiens_hsa051310.74085634
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71106191
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70033798
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69295934
40RNA degradation_Homo sapiens_hsa030180.69147589
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68063571
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.67226869
43Measles_Homo sapiens_hsa051620.65905434
44Caffeine metabolism_Homo sapiens_hsa002320.63603469
45Olfactory transduction_Homo sapiens_hsa047400.63069830
46Herpes simplex infection_Homo sapiens_hsa051680.62716538
47Homologous recombination_Homo sapiens_hsa034400.61898311
48Chemical carcinogenesis_Homo sapiens_hsa052040.61848575
49Purine metabolism_Homo sapiens_hsa002300.61694436
50Epstein-Barr virus infection_Homo sapiens_hsa051690.60777142
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.60434273
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60123539
53Spliceosome_Homo sapiens_hsa030400.56324448
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.56038988
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54568062
56Peroxisome_Homo sapiens_hsa041460.51907284
57Phagosome_Homo sapiens_hsa041450.51409492
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51384460
59Tuberculosis_Homo sapiens_hsa051520.50455500
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50141414
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50135654
62One carbon pool by folate_Homo sapiens_hsa006700.48487374
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48175698
64Fanconi anemia pathway_Homo sapiens_hsa034600.46565017
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46412767
66DNA replication_Homo sapiens_hsa030300.46125628
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44680063
68Sulfur metabolism_Homo sapiens_hsa009200.44348204
69Regulation of autophagy_Homo sapiens_hsa041400.43240342
70Pertussis_Homo sapiens_hsa051330.42662001
71Mismatch repair_Homo sapiens_hsa034300.42124815
72Malaria_Homo sapiens_hsa051440.39994688
73Legionellosis_Homo sapiens_hsa051340.39035090
74Retinol metabolism_Homo sapiens_hsa008300.38845708
75Influenza A_Homo sapiens_hsa051640.37107810
76Propanoate metabolism_Homo sapiens_hsa006400.37004703
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36176396
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32595860
79Butanoate metabolism_Homo sapiens_hsa006500.31164420
80Toxoplasmosis_Homo sapiens_hsa051450.30141674
81Linoleic acid metabolism_Homo sapiens_hsa005910.29081042
82Taste transduction_Homo sapiens_hsa047420.23292152
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22105982
84Metabolic pathways_Homo sapiens_hsa011000.21998622
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21000105
86HTLV-I infection_Homo sapiens_hsa051660.19306555
87Nicotine addiction_Homo sapiens_hsa050330.16859231
88Base excision repair_Homo sapiens_hsa034100.15983100
89Salivary secretion_Homo sapiens_hsa049700.15792441
90Tryptophan metabolism_Homo sapiens_hsa003800.15356561
91Nucleotide excision repair_Homo sapiens_hsa034200.15123860
92Vibrio cholerae infection_Homo sapiens_hsa051100.13387980
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12154247
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11553485
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.09793837
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09632696
97RNA transport_Homo sapiens_hsa030130.09020890
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.08488156
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.07649267
100Arachidonic acid metabolism_Homo sapiens_hsa005900.06432800

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