CNOT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.42066051
2positive regulation of B cell differentiation (GO:0045579)5.24830979
3protein localization to endosome (GO:0036010)5.18619200
4negative regulation of cell killing (GO:0031342)5.12129319
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.12129319
6purine nucleobase biosynthetic process (GO:0009113)4.72140014
7regulation of B cell receptor signaling pathway (GO:0050855)4.64607601
8nucleobase biosynthetic process (GO:0046112)4.56544889
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54253230
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.53455701
11mitotic metaphase plate congression (GO:0007080)4.50818100
12regulation of B cell differentiation (GO:0045577)4.23563334
13DNA strand elongation (GO:0022616)4.21103565
14telomere maintenance via semi-conservative replication (GO:0032201)4.16685926
15Arp2/3 complex-mediated actin nucleation (GO:0034314)4.15597246
16DNA strand elongation involved in DNA replication (GO:0006271)4.15047937
17DNA deamination (GO:0045006)4.03541832
18regulation of gamma-delta T cell differentiation (GO:0045586)3.95252453
19neutrophil activation involved in immune response (GO:0002283)3.90769963
20antigen processing and presentation of endogenous antigen (GO:0019883)3.89426477
21ribosome biogenesis (GO:0042254)3.83200487
22response to nerve growth factor (GO:1990089)3.82822173
23cellular response to nerve growth factor stimulus (GO:1990090)3.82822173
24telomere maintenance via recombination (GO:0000722)3.78978465
25regulation of gamma-delta T cell activation (GO:0046643)3.75828954
26formation of translation preinitiation complex (GO:0001731)3.73239454
27negative T cell selection (GO:0043383)3.71511919
28positive regulation of granulocyte differentiation (GO:0030854)3.69862649
29telomere maintenance via telomerase (GO:0007004)3.69449192
30DNA replication initiation (GO:0006270)3.68616920
31metaphase plate congression (GO:0051310)3.68419482
32telomere maintenance via telomere lengthening (GO:0010833)3.65210899
33immunoglobulin mediated immune response (GO:0016064)3.64151485
34ribosome assembly (GO:0042255)3.62796361
35DNA replication checkpoint (GO:0000076)3.62485335
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60513995
37folic acid metabolic process (GO:0046655)3.60204210
38negative thymic T cell selection (GO:0045060)3.57355502
39ribosomal small subunit assembly (GO:0000028)3.55987936
40regulation of spindle organization (GO:0090224)3.51193954
41protein localization to kinetochore (GO:0034501)3.46427247
42mitotic recombination (GO:0006312)3.45537311
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41852397
44B cell receptor signaling pathway (GO:0050853)3.40934682
45folic acid-containing compound biosynthetic process (GO:0009396)3.40879444
46mitotic nuclear envelope disassembly (GO:0007077)3.40595046
47regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.40228239
48nucleotide-excision repair, DNA gap filling (GO:0006297)3.38191352
49germ cell migration (GO:0008354)3.38147683
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36867366
51establishment of chromosome localization (GO:0051303)3.31603279
52rRNA modification (GO:0000154)3.31148125
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.28245758
54regulation of alpha-beta T cell proliferation (GO:0046640)3.28113129
55attachment of spindle microtubules to kinetochore (GO:0008608)3.27938528
56actin nucleation (GO:0045010)3.26161858
57neutrophil activation (GO:0042119)3.24682439
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.24209974
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.23241144
60termination of RNA polymerase III transcription (GO:0006386)3.23241144
61snRNA processing (GO:0016180)3.22799740
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.22103833
63RNA-dependent DNA replication (GO:0006278)3.19045041
64nuclear envelope disassembly (GO:0051081)3.18768005
65membrane disassembly (GO:0030397)3.18768005
66nucleoside salvage (GO:0043174)3.18654475
67CENP-A containing nucleosome assembly (GO:0034080)3.18492905
68DNA replication-independent nucleosome assembly (GO:0006336)3.17359195
69DNA replication-independent nucleosome organization (GO:0034724)3.17359195
70regulation of T cell tolerance induction (GO:0002664)3.15435958
71DNA-dependent DNA replication (GO:0006261)3.15275760
72negative regulation of type 2 immune response (GO:0002829)3.13768769
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12658248
74response to interleukin-15 (GO:0070672)3.11937619
75regulation of tolerance induction (GO:0002643)3.10711696
76maturation of 5.8S rRNA (GO:0000460)3.07647054
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07549031
78positive regulation of T cell cytokine production (GO:0002726)3.06941414
79IMP biosynthetic process (GO:0006188)3.05860787
80leukocyte degranulation (GO:0043299)3.05628236
81negative regulation of T cell mediated immunity (GO:0002710)3.05398956
82regulation of germinal center formation (GO:0002634)3.05270238
83mast cell activation (GO:0045576)3.03653920
84B cell mediated immunity (GO:0019724)3.03193660
85snRNA metabolic process (GO:0016073)3.03041783
86pyrimidine-containing compound salvage (GO:0008655)3.01996889
87pyrimidine nucleoside salvage (GO:0043097)3.01996889
88detection of other organism (GO:0098543)3.01624656
89detection of bacterium (GO:0016045)3.01557793
90chromatin remodeling at centromere (GO:0031055)3.01518601
91T cell migration (GO:0072678)3.01492990
92proteasome assembly (GO:0043248)3.01387684
93ribonucleoprotein complex biogenesis (GO:0022613)3.00280049
94pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.99404230
95response to peptidoglycan (GO:0032494)2.98912993
96maturation of SSU-rRNA (GO:0030490)2.98856702
97transcription-coupled nucleotide-excision repair (GO:0006283)2.97613961
98definitive hemopoiesis (GO:0060216)2.97223772
99positive thymic T cell selection (GO:0045059)2.96188601
100rRNA methylation (GO:0031167)2.95882031
101anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95845679
102viral mRNA export from host cell nucleus (GO:0046784)2.94894231
103regulation of mast cell degranulation (GO:0043304)2.93699428
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92995204
105histone H3-K36 demethylation (GO:0070544)2.91738041
106cellular response to interleukin-15 (GO:0071350)2.90392527
107antigen receptor-mediated signaling pathway (GO:0050851)2.90231623
108regulation of actin nucleation (GO:0051125)2.89819159
109protein localization to chromosome, centromeric region (GO:0071459)2.89661250
110positive T cell selection (GO:0043368)2.89417934
111pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.87856821
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86088932
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.85859049
114pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.85452869
115UMP biosynthetic process (GO:0006222)2.85452869
116pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.85452869
117UMP metabolic process (GO:0046049)2.85452869
118mitochondrial DNA replication (GO:0006264)2.85413408
119DNA unwinding involved in DNA replication (GO:0006268)2.85091122
120positive regulation of interleukin-17 production (GO:0032740)2.84068799
121Peyers patch development (GO:0048541)2.84025845
122mucosal-associated lymphoid tissue development (GO:0048537)2.84025845
123regulation of mast cell activation involved in immune response (GO:0033006)2.84013283
124IMP metabolic process (GO:0046040)2.82511225
125granulocyte activation (GO:0036230)2.81178638
126telomere maintenance (GO:0000723)2.79053293
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78868292
128telomere organization (GO:0032200)2.78313588
129leukocyte aggregation (GO:0070486)2.78186775
130negative regulation of chromosome segregation (GO:0051985)2.78068187
131negative regulation of mitotic sister chromatid separation (GO:2000816)2.77106663
132negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77106663
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77106663
134negative regulation of sister chromatid segregation (GO:0033046)2.77106663
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76986975
136positive regulation of mast cell degranulation (GO:0043306)2.76341024
137positive regulation of mast cell activation involved in immune response (GO:0033008)2.76341024
138mitotic sister chromatid segregation (GO:0000070)2.76103487
139rRNA processing (GO:0006364)2.76065257
140regulation of translation in response to stress (GO:0043555)2.75441666
141spindle checkpoint (GO:0031577)2.75261109
142mitotic spindle assembly checkpoint (GO:0007094)2.75086013
143regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74755768
144positive regulation of tolerance induction (GO:0002645)2.72124683
145spindle assembly checkpoint (GO:0071173)2.71484658
146regulation of mitotic spindle organization (GO:0060236)2.70902371
147negative regulation of leukocyte mediated immunity (GO:0002704)2.70608626
148regulation of mast cell activation (GO:0033003)2.70581681
149spliceosomal snRNP assembly (GO:0000387)2.70075005
150B cell homeostasis (GO:0001782)2.69279195
151regulation of hypersensitivity (GO:0002883)2.68852213
152T cell receptor signaling pathway (GO:0050852)2.68834016
153intracellular lipid transport (GO:0032365)2.68273406
154positive regulation of mast cell activation (GO:0033005)2.67565689
155mitotic chromosome condensation (GO:0007076)2.67267271
156rRNA metabolic process (GO:0016072)2.66089298
157folic acid transport (GO:0015884)2.65901368
158regulation of regulatory T cell differentiation (GO:0045589)2.65834651
159regulation of heat generation (GO:0031650)2.65651684
160positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.65413081
161mitotic spindle checkpoint (GO:0071174)2.65253870
162meiotic chromosome segregation (GO:0045132)2.65235674
163replication fork processing (GO:0031297)2.65160203
164positive regulation of interleukin-2 production (GO:0032743)2.65075080
165neutrophil mediated immunity (GO:0002446)2.64252706
166T cell selection (GO:0045058)2.63461108
167positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62806713
168glycine metabolic process (GO:0006544)2.62591057
169protein deneddylation (GO:0000338)2.62368610
170positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.61472499
171germinal center formation (GO:0002467)2.61302992
172interferon-gamma production (GO:0032609)2.61256210
1737-methylguanosine mRNA capping (GO:0006370)2.61188058
174mast cell activation involved in immune response (GO:0002279)2.61135903
175mast cell degranulation (GO:0043303)2.61135903
176regulation of chromosome segregation (GO:0051983)2.60768768
177T cell homeostasis (GO:0043029)2.59552079
178L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57910186
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.57725749
180oxidative phosphorylation (GO:0006119)2.57162412
181myeloid cell activation involved in immune response (GO:0002275)2.56701058
182RNA capping (GO:0036260)2.56589264
1837-methylguanosine RNA capping (GO:0009452)2.56589264
184nuclear envelope organization (GO:0006998)2.55138709
185negative regulation of T cell apoptotic process (GO:0070233)2.55121265
186lymphocyte homeostasis (GO:0002260)2.53430140
187regulation of T cell cytokine production (GO:0002724)2.52381495
188regulation of granulocyte differentiation (GO:0030852)2.51535518
189T cell costimulation (GO:0031295)2.50474787
190regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.49000110
191metallo-sulfur cluster assembly (GO:0031163)2.46449344
192iron-sulfur cluster assembly (GO:0016226)2.46449344
193lymphocyte costimulation (GO:0031294)2.46383365
194regulation of interleukin-17 production (GO:0032660)2.44840836
195negative regulation of adaptive immune response (GO:0002820)2.44791158
196negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.42792890
197negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.41380696
198regulation of isotype switching to IgG isotypes (GO:0048302)2.40860984
199positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.40783007
200negative regulation of B cell proliferation (GO:0030889)2.39787508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.41567545
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.44921376
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.28451062
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.81294437
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.58482824
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.32825759
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32507451
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.05885884
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.98259482
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89563995
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.87946535
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73165836
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71231222
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.70590121
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.70529436
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64823124
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63197201
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62935248
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53718895
20* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38849868
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34170656
22RUNX_20019798_ChIP-Seq_JUKART_Human2.32506931
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30821562
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27474554
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24100729
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22567378
27VDR_23849224_ChIP-Seq_CD4+_Human2.22318702
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.18612417
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17744078
30MYB_26560356_Chip-Seq_TH1_Human2.12197703
31XRN2_22483619_ChIP-Seq_HELA_Human2.12079125
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09315091
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08272516
34FOXP3_21729870_ChIP-Seq_TREG_Human2.05104404
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04080137
36GATA3_27048872_Chip-Seq_THYMUS_Human2.04038020
37E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03642055
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01224306
39SMAD_19615063_ChIP-ChIP_OVARY_Human2.00962644
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96312421
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.96147701
42GABP_19822575_ChIP-Seq_HepG2_Human1.96047080
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96005686
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94561241
45* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93992063
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89139384
47* DCP1A_22483619_ChIP-Seq_HELA_Human1.88203140
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86369682
49* MYC_22102868_ChIP-Seq_BL_Human1.85262234
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83045260
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77052671
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76981609
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74655112
54GATA3_26560356_Chip-Seq_TH2_Human1.73930185
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.73093250
56* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71723579
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71139664
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70249227
59* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67716873
60* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66984054
61CIITA_25753668_ChIP-Seq_RAJI_Human1.66855840
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64721452
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64698976
64AR_21909140_ChIP-Seq_LNCAP_Human1.64432099
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62093502
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61906994
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61530113
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60171697
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60029754
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.59083121
71* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55852710
72EWS_26573619_Chip-Seq_HEK293_Human1.55242491
73MAF_26560356_Chip-Seq_TH1_Human1.53638548
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53042477
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53013953
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52354706
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50533744
78IGF1R_20145208_ChIP-Seq_DFB_Human1.47647460
79TAF15_26573619_Chip-Seq_HEK293_Human1.45761767
80KDM5A_27292631_Chip-Seq_BREAST_Human1.45460771
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.44790309
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.42193921
83TTF2_22483619_ChIP-Seq_HELA_Human1.41416549
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41353878
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37983637
86* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36103252
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35470648
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34959975
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.34891054
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32682813
91* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32476455
92TFEB_21752829_ChIP-Seq_HELA_Human1.31531099
93VDR_24763502_ChIP-Seq_THP-1_Human1.29532960
94ELK1_19687146_ChIP-ChIP_HELA_Human1.29432219
95UTX_26944678_Chip-Seq_JUKART_Human1.28767948
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28629422
97* RUNX1_22412390_ChIP-Seq_EML_Mouse1.28152880
98* SPI1_23547873_ChIP-Seq_NB4_Human1.28133696
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27328901
100ZNF274_21170338_ChIP-Seq_K562_Hela1.25851039
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24863879
102VDR_24787735_ChIP-Seq_THP-1_Human1.23425132
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23183751
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22778123
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20879490
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20178630
107* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19802763
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19475614
109* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16571211
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15415531
111VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15402822
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14684161
113IRF8_21731497_ChIP-ChIP_J774_Mouse1.11815432
114GATA3_26560356_Chip-Seq_TH1_Human1.11364370
115* SPI1_23127762_ChIP-Seq_K562_Human1.10880904
116FUS_26573619_Chip-Seq_HEK293_Human1.10768063
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07529902
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07312850
119ER_23166858_ChIP-Seq_MCF-7_Human1.06962414
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06323958
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.05863884
122VDR_21846776_ChIP-Seq_THP-1_Human1.04659885
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03997338
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03825254
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03376525
126EZH2_27294783_Chip-Seq_NPCs_Mouse1.03353071
127PU_27001747_Chip-Seq_BMDM_Mouse1.03336834
128MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02519738
129* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01465083
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01346010
131SALL4_22934838_ChIP-ChIP_CD34+_Human0.94744661
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93630894
133MAF_26560356_Chip-Seq_TH2_Human0.92765509
134* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92145765
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91358986
136ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91070236
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90962206
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90188875
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89621095
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89115585
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89006369
142* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88701006
143GATA1_22025678_ChIP-Seq_K562_Human0.88116978
144* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87796692
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86733314
146CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86710691
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.86456791
148ZNF263_19887448_ChIP-Seq_K562_Human0.86090026
149FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85798771
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.85423941
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85360244
152* MYB_26560356_Chip-Seq_TH2_Human0.85202854
153NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84734591
154FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83929244
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83666997
156SCL_19346495_ChIP-Seq_HPC-7_Human0.82232890
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.81046044
158* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78901025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57061900
2MP0010094_abnormal_chromosome_stability4.02758021
3MP0003111_abnormal_nucleus_morphology3.62095948
4MP0004957_abnormal_blastocyst_morpholog3.56560303
5MP0003077_abnormal_cell_cycle3.46177402
6MP0002396_abnormal_hematopoietic_system3.24291344
7MP0008007_abnormal_cellular_replicative3.11633959
8MP0008058_abnormal_DNA_repair3.01740194
9MP0008057_abnormal_DNA_replication2.49201777
10MP0003806_abnormal_nucleotide_metabolis2.43905184
11MP0003303_peritoneal_inflammation2.29842953
12MP0006082_CNS_inflammation2.12328228
13MP0009278_abnormal_bone_marrow2.04189280
14MP0003718_maternal_effect2.00715126
15MP0009333_abnormal_splenocyte_physiolog1.99116790
16MP0009840_abnormal_foam_cell1.94654955
17MP0001790_abnormal_immune_system1.93057555
18MP0005387_immune_system_phenotype1.93057555
19MP0000350_abnormal_cell_proliferation1.80855956
20MP0001986_abnormal_taste_sensitivity1.79432001
21MP0009697_abnormal_copulation1.77284981
22MP0004808_abnormal_hematopoietic_stem1.75125592
23MP0000490_abnormal_crypts_of1.73847433
24MP0001730_embryonic_growth_arrest1.70728346
25MP0005397_hematopoietic_system_phenotyp1.68145112
26MP0001545_abnormal_hematopoietic_system1.68145112
27MP0005671_abnormal_response_to1.67319604
28MP0001835_abnormal_antigen_presentation1.65776660
29MP0008932_abnormal_embryonic_tissue1.64851509
30MP0003763_abnormal_thymus_physiology1.62198105
31MP0002398_abnormal_bone_marrow1.61471328
32MP0002139_abnormal_hepatobiliary_system1.57951083
33MP0003786_premature_aging1.57383964
34MP0002019_abnormal_tumor_incidence1.55135228
35MP0008877_abnormal_DNA_methylation1.54138599
36MP0003186_abnormal_redox_activity1.51277331
37MP0000689_abnormal_spleen_morphology1.50566604
38MP0002722_abnormal_immune_system1.49021117
39MP0004782_abnormal_surfactant_physiolog1.48121076
40MP0009785_altered_susceptibility_to1.45753080
41MP0002009_preneoplasia1.44912145
42MP0004043_abnormal_pH_regulation1.39962770
43MP0002132_abnormal_respiratory_system1.39742321
44MP0006036_abnormal_mitochondrial_physio1.36767388
45MP0010307_abnormal_tumor_latency1.36360924
46MP0001697_abnormal_embryo_size1.36346015
47MP0002080_prenatal_lethality1.36105266
48MP0001764_abnormal_homeostasis1.36024560
49MP0002006_tumorigenesis1.33370713
50MP0003724_increased_susceptibility_to1.33130903
51MP0004484_altered_response_of1.32349589
52MP0005365_abnormal_bile_salt1.31082772
53MP0002166_altered_tumor_susceptibility1.30384443
54MP0003172_abnormal_lysosome_physiology1.30151392
55MP0001800_abnormal_humoral_immune1.29869859
56MP0003191_abnormal_cellular_cholesterol1.29423338
57MP0002429_abnormal_blood_cell1.28824223
58MP0000716_abnormal_immune_system1.27116717
59MP0010352_gastrointestinal_tract_polyps1.25464217
60MP0003567_abnormal_fetal_cardiomyocyte1.25429234
61MP0000313_abnormal_cell_death1.22938732
62MP0000685_abnormal_immune_system1.22936335
63MP0001672_abnormal_embryogenesis/_devel1.22898793
64MP0005380_embryogenesis_phenotype1.22898793
65MP0003123_paternal_imprinting1.21579889
66MP0000703_abnormal_thymus_morphology1.20856031
67MP0008995_early_reproductive_senescence1.16252664
68MP0002420_abnormal_adaptive_immunity1.14366896
69MP0002723_abnormal_immune_serum1.14127027
70MP0001819_abnormal_immune_cell1.13551994
71MP0000465_gastrointestinal_hemorrhage1.13457992
72MP0004947_skin_inflammation1.12466678
73MP0009764_decreased_sensitivity_to1.11282829
74MP0003984_embryonic_growth_retardation1.07593699
75MP0002452_abnormal_antigen_presenting1.06557431
76MP0005025_abnormal_response_to1.06392455
77MP0001873_stomach_inflammation1.05651666
78MP0000858_altered_metastatic_potential1.04818272
79MP0000358_abnormal_cell_content/1.03901063
80MP0002088_abnormal_embryonic_growth/wei1.03312357
81MP0001119_abnormal_female_reproductive1.03054042
82MP0000598_abnormal_liver_morphology1.02067385
83MP0005084_abnormal_gallbladder_morpholo1.01194965
84MP0005464_abnormal_platelet_physiology1.01125449
85MP0002086_abnormal_extraembryonic_tissu1.01087192
86MP0010155_abnormal_intestine_physiology0.99459200
87MP0001533_abnormal_skeleton_physiology0.98859523
88MP0006035_abnormal_mitochondrial_morpho0.97948934
89MP0008260_abnormal_autophagy0.96581745
90MP0003866_abnormal_defecation0.96539642
91MP0000609_abnormal_liver_physiology0.95049076
92MP0003221_abnormal_cardiomyocyte_apopto0.94556054
93MP0003436_decreased_susceptibility_to0.94269001
94MP0003828_pulmonary_edema0.92475807
95MP0008004_abnormal_stomach_pH0.91915244
96MP0005310_abnormal_salivary_gland0.90520720
97MP0002405_respiratory_system_inflammati0.90242300
98MP0000681_abnormal_thyroid_gland0.90151620
99MP0005319_abnormal_enzyme/_coenzyme0.89545841
100MP0008469_abnormal_protein_level0.89420085
101MP0002085_abnormal_embryonic_tissue0.89124411
102MP0005000_abnormal_immune_tolerance0.88763557
103MP0005085_abnormal_gallbladder_physiolo0.88542396
104MP0001845_abnormal_inflammatory_respons0.86740974
105MP0002998_abnormal_bone_remodeling0.86296623
106MP0003656_abnormal_erythrocyte_physiolo0.85521874
107MP0005075_abnormal_melanosome_morpholog0.84951786
108MP0010329_abnormal_lipoprotein_level0.84544080
109MP0002419_abnormal_innate_immunity0.84539437
110MP0003943_abnormal_hepatobiliary_system0.80564842
111MP0004264_abnormal_extraembryonic_tissu0.80154609
112MP0002148_abnormal_hypersensitivity_rea0.80064560
113MP0005451_abnormal_body_composition0.78675341
114MP0002084_abnormal_developmental_patter0.77785507
115MP0009763_increased_sensitivity_to0.76842776
116MP0000569_abnormal_digit_pigmentation0.76170124
117MP0002095_abnormal_skin_pigmentation0.76082323
118MP0005384_cellular_phenotype0.75831700
119MP0001851_eye_inflammation0.75450994
120MP0001853_heart_inflammation0.75083065
121MP0005621_abnormal_cell_physiology0.74164910
122MP0000653_abnormal_sex_gland0.72169024
123MP0008873_increased_physiological_sensi0.71651387
124MP0001145_abnormal_male_reproductive0.70568367
125MP0002210_abnormal_sex_determination0.69832039
126MP0003448_altered_tumor_morphology0.69808413
127MP0005266_abnormal_metabolism0.69074155
128MP0002277_abnormal_respiratory_mucosa0.64978710
129MP0001929_abnormal_gametogenesis0.63670338
130MP0003300_gastrointestinal_ulcer0.62846769
131MP0002933_joint_inflammation0.61971170
132MP0002877_abnormal_melanocyte_morpholog0.60826216
133MP0004883_abnormal_blood_vessel0.59878912
134MP0009765_abnormal_xenobiotic_induced0.59096064
135MP0001191_abnormal_skin_condition0.59020295
136MP0000613_abnormal_salivary_gland0.58327384
137MP0001919_abnormal_reproductive_system0.57954860
138MP0001177_atelectasis0.57283099
139MP0005410_abnormal_fertilization0.56402601
140MP0008789_abnormal_olfactory_epithelium0.54271376

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.04373182
2T lymphocytopenia (HP:0005403)4.75005942
3Abnormality of T cell number (HP:0011839)4.41693921
4Abnormal delayed hypersensitivity skin test (HP:0002963)4.40015123
5Abnormality of B cell number (HP:0010975)4.21780370
6Severe combined immunodeficiency (HP:0004430)4.17450457
7B lymphocytopenia (HP:0010976)4.11899971
8Thrombocytosis (HP:0001894)3.98542942
9Elevated erythrocyte sedimentation rate (HP:0003565)3.67516994
10Recurrent fungal infections (HP:0002841)3.67477385
11Recurrent viral infections (HP:0004429)3.59995799
12Microretrognathia (HP:0000308)3.56592265
13Stomatitis (HP:0010280)3.54187576
14Aplastic anemia (HP:0001915)3.53261067
15Combined immunodeficiency (HP:0005387)3.45237083
16Chronic mucocutaneous candidiasis (HP:0002728)3.44260135
17Recurrent cutaneous fungal infections (HP:0011370)3.44260135
18Abnormality of the anterior horn cell (HP:0006802)3.41803317
19Degeneration of anterior horn cells (HP:0002398)3.41803317
20Capillary hemangiomas (HP:0005306)3.40670594
21Amyotrophic lateral sclerosis (HP:0007354)3.35058201
22Eosinophilia (HP:0001880)3.35015386
23Granulocytopenia (HP:0001913)3.33092437
24Agammaglobulinemia (HP:0004432)3.32345585
25Meningitis (HP:0001287)3.30145533
26Encephalitis (HP:0002383)3.28369490
27Abnormality of eosinophils (HP:0001879)3.21249850
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.19959753
29Rough bone trabeculation (HP:0100670)3.19808101
30Breast hypoplasia (HP:0003187)3.04544183
31Oral leukoplakia (HP:0002745)3.03141399
32Eczematoid dermatitis (HP:0000976)3.00426081
33Posterior subcapsular cataract (HP:0007787)2.98359738
34Chest pain (HP:0100749)2.81677689
35Thyroiditis (HP:0100646)2.80682483
36Retrobulbar optic neuritis (HP:0100654)2.78942827
37Optic neuritis (HP:0100653)2.78942827
38Inflammation of the large intestine (HP:0002037)2.78941447
39Carpal bone hypoplasia (HP:0001498)2.78737090
40Leukocytosis (HP:0001974)2.77652820
41Recurrent skin infections (HP:0001581)2.77549202
42Abnormality of the prostate (HP:0008775)2.73453892
43Myositis (HP:0100614)2.71516826
44Patellar aplasia (HP:0006443)2.70172566
45Bone marrow hypocellularity (HP:0005528)2.69281385
46Obstructive lung disease (HP:0006536)2.67804480
47Chronic obstructive pulmonary disease (HP:0006510)2.67804480
48Hypoplasia of the thymus (HP:0000778)2.66764980
49IgM deficiency (HP:0002850)2.66665465
50Long nose (HP:0003189)2.66462808
51Gastrointestinal inflammation (HP:0004386)2.65905947
52Pustule (HP:0200039)2.63635284
53Orchitis (HP:0100796)2.61265807
54Mediastinal lymphadenopathy (HP:0100721)2.59025397
55Facial hemangioma (HP:0000329)2.58145699
56Colon cancer (HP:0003003)2.57570700
57Vasculitis (HP:0002633)2.56607658
58Myelodysplasia (HP:0002863)2.56176067
59Hypoproteinemia (HP:0003075)2.55317323
60Stomach cancer (HP:0012126)2.54904092
61Progressive inability to walk (HP:0002505)2.54457273
62Impulsivity (HP:0100710)2.53799581
63Gingival bleeding (HP:0000225)2.53249706
64Autoimmune hemolytic anemia (HP:0001890)2.52485778
65Keratoconjunctivitis sicca (HP:0001097)2.51709832
66Aplasia/Hypoplasia of the patella (HP:0006498)2.51146239
67Neoplasm of the pancreas (HP:0002894)2.49510467
68Pancreatic cysts (HP:0001737)2.48405318
69Keratoconjunctivitis (HP:0001096)2.47997694
70Hyperglycinemia (HP:0002154)2.46501254
71Cerebral hypomyelination (HP:0006808)2.41690559
72Type I transferrin isoform profile (HP:0003642)2.40738483
73Urticaria (HP:0001025)2.40735442
74Abnormality of macrophages (HP:0004311)2.36528501
75Reduced antithrombin III activity (HP:0001976)2.34796499
76Chromsome breakage (HP:0040012)2.34326683
77Abnormality of the pleura (HP:0002103)2.33114253
78Prolonged bleeding time (HP:0003010)2.32391854
79Epistaxis (HP:0000421)2.32143124
80Pulmonary infiltrates (HP:0002113)2.32078296
81Gastrointestinal infarctions (HP:0005244)2.31216130
82Type 2 muscle fiber atrophy (HP:0003554)2.31137769
83Increased IgM level (HP:0003496)2.28686341
84Amaurosis fugax (HP:0100576)2.28455337
85Alveolar cell carcinoma (HP:0006519)2.28339569
86Abnormality of the intrinsic pathway (HP:0010989)2.25689347
87Cellular immunodeficiency (HP:0005374)2.23403694
88Muscle fiber atrophy (HP:0100295)2.22135503
89Abnormal trabecular bone morphology (HP:0100671)2.20169135
90Premature graying of hair (HP:0002216)2.20140069
91Abnormal number of erythroid precursors (HP:0012131)2.18931845
92Multiple enchondromatosis (HP:0005701)2.18798837
93Lymphoma (HP:0002665)2.18725502
94Attenuation of retinal blood vessels (HP:0007843)2.16290740
95Neoplasm of the tracheobronchial system (HP:0100552)2.15980501
96Selective tooth agenesis (HP:0001592)2.15909523
97Basal cell carcinoma (HP:0002671)2.15749567
98Viral hepatitis (HP:0006562)2.14369845
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.11895552
10011 pairs of ribs (HP:0000878)2.11018606
101Pancytopenia (HP:0001876)2.10379402
102Hemoptysis (HP:0002105)2.09225532
103Entropion (HP:0000621)2.07504047
104Neoplasm of the oral cavity (HP:0100649)2.06760540
105Agnosia (HP:0010524)2.04738599
106Abnormality of T cell physiology (HP:0011840)2.04418882
107Spontaneous hematomas (HP:0007420)2.03383774
108Abnormality of cells of the erythroid lineage (HP:0012130)2.03015413
109Recurrent bacterial skin infections (HP:0005406)2.02200409
110Secondary amenorrhea (HP:0000869)2.01427511
111Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01363685
112Reticulocytopenia (HP:0001896)2.01253145
113Conical tooth (HP:0000698)1.98525067
114Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98292608
115IgG deficiency (HP:0004315)1.97750090
116Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96943253
117Abnormality of lateral ventricle (HP:0030047)1.96930772
118Hypochromic microcytic anemia (HP:0004840)1.95028219
119Acute lymphatic leukemia (HP:0006721)1.94924318
120Lymphopenia (HP:0001888)1.94672029
121Colitis (HP:0002583)1.94546959
122Death in infancy (HP:0001522)1.94029288
123Abnormality of serum amino acid levels (HP:0003112)1.93406389
124Polycythemia (HP:0001901)1.92736671
125Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92216467
126Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92216467
127Chronic diarrhea (HP:0002028)1.90915413
128Abnormality of pyrimidine metabolism (HP:0004353)1.90436313
129Dyschromatopsia (HP:0007641)1.90175111
130Abnormality of T cells (HP:0002843)1.89897391
131Abnormality of chromosome stability (HP:0003220)1.89120813
132Progressive muscle weakness (HP:0003323)1.89081505
133Renal cortical cysts (HP:0000803)1.88951365
134Metaphyseal dysplasia (HP:0100255)1.87730353
135Petechiae (HP:0000967)1.86471390
136Spontaneous abortion (HP:0005268)1.86112227
137Poikiloderma (HP:0001029)1.85849128
138Hyperglycinuria (HP:0003108)1.85806302
139Premature ovarian failure (HP:0008209)1.84652283
140Abnormality of macular pigmentation (HP:0008002)1.82895269
141Abnormal neuron morphology (HP:0012757)1.82689498
142Abnormality of the motor neurons (HP:0002450)1.82689498
143Papillary thyroid carcinoma (HP:0002895)1.82512713
144Abnormality of cells of the lymphoid lineage (HP:0012140)1.81548031
145Sepsis (HP:0100806)1.81203537
146Broad alveolar ridges (HP:0000187)1.79855217
147Acute myeloid leukemia (HP:0004808)1.79440339
148Broad-based gait (HP:0002136)1.79286466
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79114885
150Tinnitus (HP:0000360)1.79003163
151Recurrent gram-negative bacterial infections (HP:0005420)1.77759769
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77579355
153Abnormal protein N-linked glycosylation (HP:0012347)1.77579355
154Abnormal protein glycosylation (HP:0012346)1.77579355
155Abnormal glycosylation (HP:0012345)1.77579355
156Broad palm (HP:0001169)1.77515648
157Recurrent abscess formation (HP:0002722)1.77328518
158Premature loss of primary teeth (HP:0006323)1.75350813
159CNS hypomyelination (HP:0003429)1.74940999
160Hypobetalipoproteinemia (HP:0003563)1.74486309
161Abnormality of fatty-acid metabolism (HP:0004359)1.73903648
162Abnormality of the preputium (HP:0100587)1.73844699
163Ependymoma (HP:0002888)1.73503409
164Pulmonary embolism (HP:0002204)1.72366989
165Ragged-red muscle fibers (HP:0003200)1.71967839
166Hypoplasia of the pons (HP:0012110)1.71845498
167Hepatosplenomegaly (HP:0001433)1.71819299
168Joint swelling (HP:0001386)1.70290001
169Teleangiectasia of the skin (HP:0100585)1.70068169
170Panhypogammaglobulinemia (HP:0003139)1.69661629
171Sloping forehead (HP:0000340)1.68841060
172Abnormality of alanine metabolism (HP:0010916)1.68526223
173Hyperalaninemia (HP:0003348)1.68526223
174Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68526223
175Hepatic necrosis (HP:0002605)1.68219290
176Increased serum lactate (HP:0002151)1.67524405
177Upper motor neuron abnormality (HP:0002127)1.67489997
178Abnormal lung lobation (HP:0002101)1.66986695
179Megaloblastic anemia (HP:0001889)1.66406042
180Aplasia/Hypoplasia of the uvula (HP:0010293)1.65692912

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.47991383
2TAOK33.96666119
3BCR3.36545884
4WEE13.26534981
5CDK192.89909528
6PLK42.62798670
7TSSK62.57252611
8EIF2AK12.53026368
9RIPK42.49690452
10CDC72.35679714
11NEK22.35390127
12GRK62.26892005
13BRSK22.26617733
14FLT32.25797824
15EIF2AK32.22697079
16MAP3K142.20206671
17MAP3K132.15061544
18HCK2.03371747
19NME22.01688789
20NEK11.93286755
21FES1.90841354
22TESK21.87710024
23ERBB31.87019817
24CCNB11.80129442
25ITK1.79107404
26MAP2K31.78599390
27PLK11.76953898
28TTK1.74565677
29STK161.72128415
30VRK11.68707546
31PIM21.68203047
32MAP4K11.67086869
33IKBKE1.66436504
34BMPR21.65642762
35TGFBR11.64196936
36DYRK31.63175781
37ACVR1B1.61796132
38SIK31.57237965
39PASK1.53606632
40IRAK41.48749934
41PLK31.47278807
42BRSK11.46758848
43KIT1.46748250
44BCKDK1.45619540
45EEF2K1.42803337
46SCYL21.41896672
47TRIM281.39245551
48TNK21.38620942
49SRPK11.37845549
50CAMKK21.36290738
51CDK31.34971136
52MAP4K21.30501606
53ZAK1.30324917
54CSK1.26162738
55AURKB1.25703407
56RPS6KA41.25673045
57RPS6KB21.24262991
58TYK21.22621489
59CHEK21.19495339
60CDC42BPA1.18324208
61CSF1R1.13330106
62BTK1.13176029
63MATK1.11885033
64CDK71.09948331
65ZAP701.08693180
66ATR1.08577881
67CDK41.05480882
68TEC1.04675207
69BRAF1.03870059
70STK101.02963473
71MKNK11.02727534
72TLK10.99325871
73MKNK20.99284542
74KDR0.98604801
75PIM10.93151450
76AURKA0.92793178
77MAP3K60.89291524
78PAK40.88273725
79JAK30.86424357
80TXK0.84398160
81IKBKB0.83984171
82TBK10.83518914
83MAPKAPK30.83228349
84MAPK110.81312469
85CDK80.81195489
86SIK20.80984202
87CLK10.80982943
88STK30.80041620
89YES10.79902801
90IRAK20.79645993
91MAP3K80.78922226
92NLK0.77350217
93ARAF0.77253079
94CSNK1G20.75436087
95FGR0.74974067
96ABL10.74051775
97TAOK10.73055782
98CSNK1G30.72101818
99AKT30.71894719
100JAK20.71042822
101DYRK20.69703272
102TNIK0.68154543
103PRKCI0.67701079
104IRAK10.65655588
105PRKCQ0.65170684
106BLK0.64780360
107MAPK70.62847526
108STK38L0.61411347
109TIE10.60881217
110CHEK10.60144777
111CSNK1A1L0.59398942
112MAP3K40.57255758
113FGFR40.56257337
114MAP3K110.55610301
115EGFR0.54055892
116MAPK130.53999141
117CHUK0.53623026
118STK40.52730743
119RAF10.51760658
120CSNK2A10.51361920
121MAP3K50.50986256
122MAP3K30.50323375
123TGFBR20.50061217
124BRD40.48452723
125DYRK1B0.48422383
126LCK0.47794908
127SYK0.47694732
128EPHA20.47463728
129CDK20.46915023
130STK240.46510672
131JAK10.46156367
132IGF1R0.45699940
133CDK60.44987331
134CSNK2A20.44627628
135LYN0.44060865
136MELK0.43951822
137CSNK1G10.43819122
138EIF2AK20.43505947
139FYN0.43145312
140PKN20.41416230
141GRK10.40853752
142RPS6KA50.39967481
143RPS6KC10.39322456
144RPS6KL10.39322456
145RPS6KA60.36977279
146PAK10.36382742
147MAP3K70.35968405
148PDK10.35591699
149ERN10.35488152
150NUAK10.35475691
151EPHA30.35353420
152LATS10.34181198
153MARK30.34180608
154RPS6KB10.32678509
155OXSR10.29609252
156PIK3CG0.29188442
157CAMKK10.27395237
158ATM0.26480047

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.37375950
2Mismatch repair_Homo sapiens_hsa034303.84304870
3RNA polymerase_Homo sapiens_hsa030203.22837188
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.18802678
5Allograft rejection_Homo sapiens_hsa053302.99615986
6Graft-versus-host disease_Homo sapiens_hsa053322.95748797
7Autoimmune thyroid disease_Homo sapiens_hsa053202.91823059
8Base excision repair_Homo sapiens_hsa034102.87096617
9Vitamin B6 metabolism_Homo sapiens_hsa007502.79694037
10Proteasome_Homo sapiens_hsa030502.65866594
11Pyrimidine metabolism_Homo sapiens_hsa002402.63945398
12Asthma_Homo sapiens_hsa053102.60135301
13RNA transport_Homo sapiens_hsa030132.48961373
14Nucleotide excision repair_Homo sapiens_hsa034202.43356826
15Spliceosome_Homo sapiens_hsa030402.34609465
16Homologous recombination_Homo sapiens_hsa034402.34431579
17Cell cycle_Homo sapiens_hsa041102.29230186
18Drug metabolism - other enzymes_Homo sapiens_hsa009832.13382426
19Ribosome_Homo sapiens_hsa030102.10695683
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00738745
21B cell receptor signaling pathway_Homo sapiens_hsa046621.99265761
22One carbon pool by folate_Homo sapiens_hsa006701.97676841
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94948864
24Viral myocarditis_Homo sapiens_hsa054161.82635868
25Folate biosynthesis_Homo sapiens_hsa007901.80824163
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78375728
27Osteoclast differentiation_Homo sapiens_hsa043801.77780783
28Selenocompound metabolism_Homo sapiens_hsa004501.76043519
29T cell receptor signaling pathway_Homo sapiens_hsa046601.69037201
30Non-homologous end-joining_Homo sapiens_hsa034501.65837246
31* RNA degradation_Homo sapiens_hsa030181.60807707
32Tuberculosis_Homo sapiens_hsa051521.59823825
33Basal transcription factors_Homo sapiens_hsa030221.48461049
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47628775
35Pentose phosphate pathway_Homo sapiens_hsa000301.42230645
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42209684
37p53 signaling pathway_Homo sapiens_hsa041151.41557192
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34453231
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33637485
40Fanconi anemia pathway_Homo sapiens_hsa034601.28964811
41Biosynthesis of amino acids_Homo sapiens_hsa012301.26059194
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24541003
43Purine metabolism_Homo sapiens_hsa002301.21940235
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21341493
45Rheumatoid arthritis_Homo sapiens_hsa053231.19454336
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.18742007
47Primary immunodeficiency_Homo sapiens_hsa053401.15154447
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15019556
49Sulfur relay system_Homo sapiens_hsa041221.14693326
50Chemokine signaling pathway_Homo sapiens_hsa040621.12863585
51Herpes simplex infection_Homo sapiens_hsa051681.12197726
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11439558
53Epstein-Barr virus infection_Homo sapiens_hsa051691.10657855
54Toxoplasmosis_Homo sapiens_hsa051451.09888466
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09310474
56Antigen processing and presentation_Homo sapiens_hsa046121.04321209
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91622742
58Measles_Homo sapiens_hsa051620.86506265
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86144180
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85999370
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84589701
62mRNA surveillance pathway_Homo sapiens_hsa030150.83358828
63Platelet activation_Homo sapiens_hsa046110.82647586
64Legionellosis_Homo sapiens_hsa051340.81231146
65Protein export_Homo sapiens_hsa030600.81145581
66Regulation of autophagy_Homo sapiens_hsa041400.79588400
67Malaria_Homo sapiens_hsa051440.79359813
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.79021952
69Salmonella infection_Homo sapiens_hsa051320.77815630
70Phagosome_Homo sapiens_hsa041450.77470032
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75830019
72Pertussis_Homo sapiens_hsa051330.74617365
73Carbon metabolism_Homo sapiens_hsa012000.73944490
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70261309
75African trypanosomiasis_Homo sapiens_hsa051430.70006434
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.69667081
77Pancreatic cancer_Homo sapiens_hsa052120.69368286
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68639059
79Caffeine metabolism_Homo sapiens_hsa002320.67216698
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64522569
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64318850
82Endocytosis_Homo sapiens_hsa041440.61601367
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60300140
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59870121
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.59667238
86Non-small cell lung cancer_Homo sapiens_hsa052230.59645475
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.59377965
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57279751
89mTOR signaling pathway_Homo sapiens_hsa041500.56718136
90Thyroid cancer_Homo sapiens_hsa052160.55426003
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.54657734
92Viral carcinogenesis_Homo sapiens_hsa052030.54142594
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52823853
94Vitamin digestion and absorption_Homo sapiens_hsa049770.52602791
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52433109
96Galactose metabolism_Homo sapiens_hsa000520.51907523
97Influenza A_Homo sapiens_hsa051640.50606493
98Fructose and mannose metabolism_Homo sapiens_hsa000510.50588483
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.50093372
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49978754
101Colorectal cancer_Homo sapiens_hsa052100.48953463
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48820706
103HTLV-I infection_Homo sapiens_hsa051660.48728093
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.48208628
105Prolactin signaling pathway_Homo sapiens_hsa049170.47454834
106Leishmaniasis_Homo sapiens_hsa051400.45981917
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45500394
108Oocyte meiosis_Homo sapiens_hsa041140.45163894
109Peroxisome_Homo sapiens_hsa041460.44699044
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44619542
111Shigellosis_Homo sapiens_hsa051310.44106932
112Chronic myeloid leukemia_Homo sapiens_hsa052200.43201872
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42553307
114Systemic lupus erythematosus_Homo sapiens_hsa053220.42002955
115Lysosome_Homo sapiens_hsa041420.41890494
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.40771710
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.40602261
118Hepatitis B_Homo sapiens_hsa051610.38608349
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38351986
120Apoptosis_Homo sapiens_hsa042100.38087044
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37913963
122Taste transduction_Homo sapiens_hsa047420.37732199
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37530482
124Glutathione metabolism_Homo sapiens_hsa004800.36545860
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.35578869
126VEGF signaling pathway_Homo sapiens_hsa043700.35520094
127Hematopoietic cell lineage_Homo sapiens_hsa046400.34975796
128Olfactory transduction_Homo sapiens_hsa047400.34828469
129Staphylococcus aureus infection_Homo sapiens_hsa051500.34735064
130Retinol metabolism_Homo sapiens_hsa008300.34706124
131N-Glycan biosynthesis_Homo sapiens_hsa005100.34668751
132Ether lipid metabolism_Homo sapiens_hsa005650.34226210
133Metabolic pathways_Homo sapiens_hsa011000.34186838
134TNF signaling pathway_Homo sapiens_hsa046680.33109110
135Renin-angiotensin system_Homo sapiens_hsa046140.31241564
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30576179
137Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29997896
138Renal cell carcinoma_Homo sapiens_hsa052110.29885621
139Phototransduction_Homo sapiens_hsa047440.27961618
140Choline metabolism in cancer_Homo sapiens_hsa052310.27910458
141Arginine biosynthesis_Homo sapiens_hsa002200.27207597
142Acute myeloid leukemia_Homo sapiens_hsa052210.24828086
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22739227
144Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21155732
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21107086
146Arginine and proline metabolism_Homo sapiens_hsa003300.21054853
147Tryptophan metabolism_Homo sapiens_hsa003800.20165338
148Complement and coagulation cascades_Homo sapiens_hsa046100.20152087
149Fatty acid degradation_Homo sapiens_hsa000710.19496400
150Type I diabetes mellitus_Homo sapiens_hsa049400.19442466
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18771662
152Hepatitis C_Homo sapiens_hsa051600.15694304
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15647128

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