CNOT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)4.72879010
2DNA double-strand break processing (GO:0000729)4.72722767
3DNA deamination (GO:0045006)4.71968045
4proteasome assembly (GO:0043248)4.68457866
5replication fork processing (GO:0031297)4.24557005
6respiratory chain complex IV assembly (GO:0008535)4.22797580
7chromatin remodeling at centromere (GO:0031055)3.99205937
8negative regulation of telomere maintenance (GO:0032205)3.92247946
9cytochrome complex assembly (GO:0017004)3.85944215
10negative regulation of DNA-dependent DNA replication (GO:2000104)3.83115860
11DNA replication checkpoint (GO:0000076)3.78051150
12cullin deneddylation (GO:0010388)3.77585930
13CENP-A containing nucleosome assembly (GO:0034080)3.74844979
14protein deneddylation (GO:0000338)3.61846186
15lactate metabolic process (GO:0006089)3.57401436
16histone exchange (GO:0043486)3.56845394
17regulation of helicase activity (GO:0051095)3.52218482
18DNA catabolic process, exonucleolytic (GO:0000738)3.51212809
19protein complex biogenesis (GO:0070271)3.50901143
20telomere maintenance via telomerase (GO:0007004)3.48477036
21water-soluble vitamin biosynthetic process (GO:0042364)3.45668998
22synapsis (GO:0007129)3.43424146
23somatic hypermutation of immunoglobulin genes (GO:0016446)3.43117336
24somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43117336
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40829342
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39870833
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39184493
28maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38427957
29mitochondrial respiratory chain complex assembly (GO:0033108)3.36636215
30somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.35881681
31isotype switching (GO:0045190)3.35881681
32somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.35881681
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35195514
34recombinational repair (GO:0000725)3.32185767
35regulation of mitotic spindle checkpoint (GO:1903504)3.31741484
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31741484
37double-strand break repair via homologous recombination (GO:0000724)3.29808421
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24116529
39DNA strand elongation involved in DNA replication (GO:0006271)3.21631944
40telomere maintenance via semi-conservative replication (GO:0032201)3.20704309
41histone H2A acetylation (GO:0043968)3.19164117
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18482163
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17812315
44signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17812315
45signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17812315
46regulation of cellular amino acid metabolic process (GO:0006521)3.17713574
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15393365
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12350705
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.12350705
50NADH dehydrogenase complex assembly (GO:0010257)3.12350705
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12146920
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12146920
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.10646117
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08415272
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.06179699
56DNA strand renaturation (GO:0000733)3.05415220
57rRNA modification (GO:0000154)3.05363889
58telomere maintenance via telomere lengthening (GO:0010833)3.04955257
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.03913949
60postreplication repair (GO:0006301)3.02060535
61DNA strand elongation (GO:0022616)3.01816370
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01618199
63signal transduction involved in DNA damage checkpoint (GO:0072422)3.01618199
64negative regulation of ligase activity (GO:0051352)3.00816483
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00816483
66platelet dense granule organization (GO:0060155)2.99758134
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97287961
68maturation of 5.8S rRNA (GO:0000460)2.96993629
69kinetochore assembly (GO:0051382)2.91902323
70kinetochore organization (GO:0051383)2.90960011
71DNA replication-dependent nucleosome organization (GO:0034723)2.85070695
72DNA replication-dependent nucleosome assembly (GO:0006335)2.85070695
73nucleotide-excision repair, DNA gap filling (GO:0006297)2.84059313
74DNA damage response, detection of DNA damage (GO:0042769)2.83344179
75mitotic recombination (GO:0006312)2.82253173
76telomere maintenance via recombination (GO:0000722)2.82078825
77regulation of DNA endoreduplication (GO:0032875)2.81033454
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.80291286
79regulation of telomere maintenance (GO:0032204)2.79931880
80pseudouridine synthesis (GO:0001522)2.78802966
81double-strand break repair (GO:0006302)2.78270254
82purine nucleobase biosynthetic process (GO:0009113)2.76198205
83nucleobase biosynthetic process (GO:0046112)2.75524759
84rRNA methylation (GO:0031167)2.74908232
85response to pheromone (GO:0019236)2.74104150
86DNA ligation (GO:0006266)2.73463217
87non-recombinational repair (GO:0000726)2.72932832
88double-strand break repair via nonhomologous end joining (GO:0006303)2.72932832
89somatic diversification of immunoglobulins (GO:0016445)2.70378605
90positive regulation of ligase activity (GO:0051351)2.70372029
91response to X-ray (GO:0010165)2.69235325
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.67444213
93termination of RNA polymerase III transcription (GO:0006386)2.67444213
94regulation of meiosis I (GO:0060631)2.67414630
95somatic recombination of immunoglobulin gene segments (GO:0016447)2.66140924
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66050395
97regulation of centriole replication (GO:0046599)2.65102764
98resolution of meiotic recombination intermediates (GO:0000712)2.64918411
99DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.64757740
100DNA replication-independent nucleosome organization (GO:0034724)2.64282165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48480536
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42434322
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.37777557
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.36989484
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30460178
6ZNF274_21170338_ChIP-Seq_K562_Hela2.93112500
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.90848903
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75724457
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.73980231
10ELK1_19687146_ChIP-ChIP_HELA_Human2.55462472
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42961240
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41139480
13VDR_22108803_ChIP-Seq_LS180_Human2.36593443
14VDR_23849224_ChIP-Seq_CD4+_Human2.18232783
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15427410
16EWS_26573619_Chip-Seq_HEK293_Human2.12997736
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.08880594
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05978319
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05416059
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02254535
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.98007992
22MYC_18940864_ChIP-ChIP_HL60_Human1.92906489
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92410408
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91476025
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89703962
26FOXP3_21729870_ChIP-Seq_TREG_Human1.89596454
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88170996
28FUS_26573619_Chip-Seq_HEK293_Human1.81758905
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.76412198
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76055750
31GBX2_23144817_ChIP-Seq_PC3_Human1.73555297
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.73277437
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69924310
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69759140
35IGF1R_20145208_ChIP-Seq_DFB_Human1.68724277
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66759650
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.63533406
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61937575
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60933223
40P300_19829295_ChIP-Seq_ESCs_Human1.59262663
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54255244
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48295869
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45053744
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39734167
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36771506
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34047995
47TAF15_26573619_Chip-Seq_HEK293_Human1.31577374
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30915927
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.30024031
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29655045
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.28328051
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.28196944
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27677082
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25627603
55IRF1_19129219_ChIP-ChIP_H3396_Human1.25092651
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24811838
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23543044
58DCP1A_22483619_ChIP-Seq_HELA_Human1.23304155
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22906474
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.22887074
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21972520
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19821090
63ER_23166858_ChIP-Seq_MCF-7_Human1.19458649
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19389490
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16726349
66CBP_20019798_ChIP-Seq_JUKART_Human1.16726349
67TP53_22573176_ChIP-Seq_HFKS_Human1.14747874
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14203009
69GABP_19822575_ChIP-Seq_HepG2_Human1.13401362
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12346285
71AR_21909140_ChIP-Seq_LNCAP_Human1.10780950
72NANOG_19829295_ChIP-Seq_ESCs_Human1.09069747
73SOX2_19829295_ChIP-Seq_ESCs_Human1.09069747
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.04602322
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02054326
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01956342
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.01956342
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01748155
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.01690769
80BCAT_22108803_ChIP-Seq_LS180_Human1.00646140
81MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99042817
82TCF4_22108803_ChIP-Seq_LS180_Human0.97121483
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96936113
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96767067
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96041901
86P300_18555785_Chip-Seq_ESCs_Mouse0.92556466
87P53_22387025_ChIP-Seq_ESCs_Mouse0.92555248
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92020937
89MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91843365
90HTT_18923047_ChIP-ChIP_STHdh_Human0.91571685
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91512136
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.91458453
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90945627
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90367712
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90163231
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90039225
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89581866
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.89441474
99SMAD4_21799915_ChIP-Seq_A2780_Human0.87792013
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.87539178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.90073885
2MP0010094_abnormal_chromosome_stability3.87151772
3MP0008058_abnormal_DNA_repair3.60594323
4MP0002102_abnormal_ear_morphology3.28722506
5MP0000372_irregular_coat_pigmentation2.98711474
6MP0003195_calcinosis2.98626880
7MP0006072_abnormal_retinal_apoptosis2.64699998
8MP0003693_abnormal_embryo_hatching2.52818572
9MP0003111_abnormal_nucleus_morphology2.51764739
10MP0003786_premature_aging2.43130487
11MP0002163_abnormal_gland_morphology2.41520990
12MP0008057_abnormal_DNA_replication2.12972457
13MP0003718_maternal_effect2.04643859
14MP0002938_white_spotting2.04283249
15MP0005379_endocrine/exocrine_gland_phen2.04166888
16MP0003787_abnormal_imprinting2.00672487
17MP0005075_abnormal_melanosome_morpholog1.96290973
18MP0004957_abnormal_blastocyst_morpholog1.91038583
19MP0009697_abnormal_copulation1.84452565
20MP0003806_abnormal_nucleotide_metabolis1.83866195
21MP0008007_abnormal_cellular_replicative1.80942929
22MP0002837_dystrophic_cardiac_calcinosis1.71010298
23MP0005551_abnormal_eye_electrophysiolog1.68266876
24MP0005253_abnormal_eye_physiology1.66033844
25MP0006292_abnormal_olfactory_placode1.61662499
26MP0003077_abnormal_cell_cycle1.60220671
27MP0005646_abnormal_pituitary_gland1.55584859
28MP0003121_genomic_imprinting1.55275750
29MP0008995_early_reproductive_senescence1.51813119
30MP0006036_abnormal_mitochondrial_physio1.51269993
31MP0002751_abnormal_autonomic_nervous1.46211262
32MP0001529_abnormal_vocalization1.40755320
33MP0005645_abnormal_hypothalamus_physiol1.37394021
34MP0002876_abnormal_thyroid_physiology1.37198525
35MP0005084_abnormal_gallbladder_morpholo1.34451013
36MP0005367_renal/urinary_system_phenotyp1.33388211
37MP0000516_abnormal_urinary_system1.33388211
38MP0008932_abnormal_embryonic_tissue1.33051187
39MP0008875_abnormal_xenobiotic_pharmacok1.32358652
40MP0008872_abnormal_physiological_respon1.31543909
41MP0004133_heterotaxia1.30753064
42MP0000647_abnormal_sebaceous_gland1.30151977
43MP0005389_reproductive_system_phenotype1.27006144
44MP0002160_abnormal_reproductive_system1.26092738
45MP0004147_increased_porphyrin_level1.25834468
46MP0000631_abnormal_neuroendocrine_gland1.20928484
47MP0001929_abnormal_gametogenesis1.19778814
48MP0001984_abnormal_olfaction1.19004046
49MP0002736_abnormal_nociception_after1.17907576
50MP0000427_abnormal_hair_cycle1.15517754
51MP0001485_abnormal_pinna_reflex1.13743156
52MP0010307_abnormal_tumor_latency1.13003154
53MP0006035_abnormal_mitochondrial_morpho1.07522167
54MP0000015_abnormal_ear_pigmentation1.06412908
55MP0005187_abnormal_penis_morphology1.04546242
56MP0009046_muscle_twitch1.04505569
57MP0005174_abnormal_tail_pigmentation1.04121285
58MP0000653_abnormal_sex_gland1.02722165
59MP0005395_other_phenotype1.01577017
60MP0006054_spinal_hemorrhage1.00954145
61MP0002095_abnormal_skin_pigmentation1.00889592
62MP0002210_abnormal_sex_determination1.00843335
63MP0003937_abnormal_limbs/digits/tail_de1.00087267
64MP0003646_muscle_fatigue0.99443606
65MP0005408_hypopigmentation0.99097245
66MP0001968_abnormal_touch/_nociception0.98872165
67MP0001919_abnormal_reproductive_system0.97938336
68MP0001119_abnormal_female_reproductive0.97705332
69MP0008789_abnormal_olfactory_epithelium0.95520590
70MP0001324_abnormal_eye_pigmentation0.95299815
71MP0002090_abnormal_vision0.94370792
72MP0001145_abnormal_male_reproductive0.94289002
73MP0004043_abnormal_pH_regulation0.93274289
74MP0003890_abnormal_embryonic-extraembry0.92794305
75MP0002282_abnormal_trachea_morphology0.92690410
76MP0001293_anophthalmia0.92014018
77MP0003119_abnormal_digestive_system0.90749978
78MP0002254_reproductive_system_inflammat0.89740507
79MP0001764_abnormal_homeostasis0.89368673
80MP0003186_abnormal_redox_activity0.86349586
81MP0005220_abnormal_exocrine_pancreas0.85561229
82MP0000613_abnormal_salivary_gland0.83787112
83MP0003880_abnormal_central_pattern0.83254292
84MP0003283_abnormal_digestive_organ0.80954241
85MP0005332_abnormal_amino_acid0.80813329
86MP0003011_delayed_dark_adaptation0.80605551
87MP0003698_abnormal_male_reproductive0.80160024
88MP0002638_abnormal_pupillary_reflex0.78044399
89MP0003122_maternal_imprinting0.77760116
90MP0009745_abnormal_behavioral_response0.77158539
91MP0010234_abnormal_vibrissa_follicle0.72946396
92MP0002234_abnormal_pharynx_morphology0.72802990
93MP0003567_abnormal_fetal_cardiomyocyte0.72539877
94MP0003136_yellow_coat_color0.71133864
95MP0005195_abnormal_posterior_eye0.68805885
96MP0004215_abnormal_myocardial_fiber0.68549020
97MP0009780_abnormal_chondrocyte_physiolo0.68151545
98MP0003943_abnormal_hepatobiliary_system0.66943612
99MP0001188_hyperpigmentation0.66367237
100MP0002928_abnormal_bile_duct0.65858473

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61905632
2Chromsome breakage (HP:0040012)3.42755883
3Abnormality of the labia minora (HP:0012880)3.33646819
4Meckel diverticulum (HP:0002245)3.22405705
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.20243084
6Abnormality of the ileum (HP:0001549)3.13814609
7Pancreatic cysts (HP:0001737)3.13044652
8Abnormality of chromosome stability (HP:0003220)3.02018341
9Colon cancer (HP:0003003)2.98760392
10Increased CSF lactate (HP:0002490)2.96761282
11Acute necrotizing encephalopathy (HP:0006965)2.93045436
12Hepatocellular necrosis (HP:0001404)2.83802285
13Pancreatic fibrosis (HP:0100732)2.82927123
14Molar tooth sign on MRI (HP:0002419)2.82463004
15Abnormality of midbrain morphology (HP:0002418)2.82463004
16Mitochondrial inheritance (HP:0001427)2.81797369
17Abnormality of the preputium (HP:0100587)2.81101435
18Ependymoma (HP:0002888)2.78775983
19Progressive macrocephaly (HP:0004481)2.77741471
20True hermaphroditism (HP:0010459)2.74389134
21Hepatic necrosis (HP:0002605)2.70943774
22Acute encephalopathy (HP:0006846)2.70831055
23Methylmalonic acidemia (HP:0002912)2.70706690
24Small intestinal stenosis (HP:0012848)2.59484962
25Duodenal stenosis (HP:0100867)2.59484962
26Neoplasm of the adrenal cortex (HP:0100641)2.57950021
27Nephronophthisis (HP:0000090)2.50050856
28Abnormal mitochondria in muscle tissue (HP:0008316)2.44765557
29Hypothermia (HP:0002045)2.43804218
30Intestinal atresia (HP:0011100)2.43783842
31Abnormality of the duodenum (HP:0002246)2.43135302
32Pendular nystagmus (HP:0012043)2.39974577
33Astrocytoma (HP:0009592)2.34340313
34Abnormality of the astrocytes (HP:0100707)2.34340313
35Glioma (HP:0009733)2.33495939
36Increased hepatocellular lipid droplets (HP:0006565)2.31886337
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.26851315
38Hypoplasia of the fovea (HP:0007750)2.26851315
39Neoplasm of the adrenal gland (HP:0100631)2.26597389
40Hyperinsulinemic hypoglycemia (HP:0000825)2.23016982
41Thyroiditis (HP:0100646)2.22310021
42Lipid accumulation in hepatocytes (HP:0006561)2.21993766
43Methylmalonic aciduria (HP:0012120)2.21753041
44Sloping forehead (HP:0000340)2.21276282
45Pancreatic islet-cell hyperplasia (HP:0004510)2.20014322
46Clubbing of toes (HP:0100760)2.19398554
47Congenital stationary night blindness (HP:0007642)2.16494221
48Increased serum lactate (HP:0002151)2.16186160
49Volvulus (HP:0002580)2.14510718
50Gastrointestinal atresia (HP:0002589)2.08102903
51Abnormality of the renal medulla (HP:0100957)2.01822322
52Abnormality of the fovea (HP:0000493)2.00747246
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00737805
54Cerebral edema (HP:0002181)2.00645999
55Abnormality of the renal cortex (HP:0011035)2.00581542
56Ectopic kidney (HP:0000086)1.99722096
57Medial flaring of the eyebrow (HP:0010747)1.98629963
58Small hand (HP:0200055)1.96806577
59Absent thumb (HP:0009777)1.96694879
60Abolished electroretinogram (ERG) (HP:0000550)1.93471283
61Abnormality of methionine metabolism (HP:0010901)1.91819932
62Aplasia/Hypoplasia of the tongue (HP:0010295)1.91588857
63Abnormal lung lobation (HP:0002101)1.90877832
64Ketoacidosis (HP:0001993)1.90324238
65Abnormality of the pancreatic islet cells (HP:0006476)1.88612510
66Abnormality of endocrine pancreas physiology (HP:0012093)1.88612510
67Type I transferrin isoform profile (HP:0003642)1.87576082
68Hypoglycemic coma (HP:0001325)1.86591898
69Abnormality of glycolysis (HP:0004366)1.85852304
70Increased serum pyruvate (HP:0003542)1.82829565
71Lactic acidosis (HP:0003128)1.82655174
72Severe combined immunodeficiency (HP:0004430)1.80915277
73Abnormality of vitamin B metabolism (HP:0004340)1.80402477
74Progressive inability to walk (HP:0002505)1.79844340
75Abnormal biliary tract physiology (HP:0012439)1.79344727
76Bile duct proliferation (HP:0001408)1.79344727
77Breast carcinoma (HP:0003002)1.79218387
78Sclerocornea (HP:0000647)1.79041841
79Abnormality of the carotid arteries (HP:0005344)1.77844344
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77689485
81Abnormal protein N-linked glycosylation (HP:0012347)1.77689485
82Abnormal protein glycosylation (HP:0012346)1.77689485
83Abnormal glycosylation (HP:0012345)1.77689485
84Aplasia/hypoplasia of the uterus (HP:0008684)1.77483466
85Optic disc pallor (HP:0000543)1.76807625
86Myelodysplasia (HP:0002863)1.76386184
87Aqueductal stenosis (HP:0002410)1.75232851
88Hypoglycemic seizures (HP:0002173)1.73748094
89Dandy-Walker malformation (HP:0001305)1.73733439
90Renal cortical cysts (HP:0000803)1.73449675
913-Methylglutaconic aciduria (HP:0003535)1.70204960
92Renal Fanconi syndrome (HP:0001994)1.69872351
93Hyperglycinemia (HP:0002154)1.69106777
94Abnormality of the pons (HP:0007361)1.68855687
95Esophageal atresia (HP:0002032)1.68116589
96Respiratory failure (HP:0002878)1.67346867
97Prostate neoplasm (HP:0100787)1.67346641
98Chronic hepatic failure (HP:0100626)1.67296848
99Preaxial hand polydactyly (HP:0001177)1.65066940
100Albinism (HP:0001022)1.63901509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.72716120
2NUAK13.15492420
3EIF2AK33.13585532
4TRIM282.90289711
5MAP4K22.89049891
6MST42.86022899
7BUB12.85311247
8VRK22.81583277
9EIF2AK12.44293211
10WNK32.39272201
11PLK32.25992436
12BMPR1B2.24549027
13MKNK22.23936098
14ZAK2.22494031
15TNIK2.06827942
16PLK42.06527221
17CDC71.97571749
18WEE11.91907688
19TAF11.86061084
20PLK21.83309084
21BRSK21.77945568
22ERBB31.75197564
23TSSK61.71247173
24TLK11.68637169
25VRK11.66454086
26TTK1.65008071
27MKNK11.56476450
28GRK11.53520283
29ACVR1B1.49809899
30NEK11.47964911
31SRPK11.43049215
32BCR1.36642579
33FGFR21.32056354
34ADRBK21.30124355
35INSRR1.21700500
36PLK11.19288013
37EIF2AK21.12928399
38CSNK1G31.07526567
39OXSR11.04335835
40CSNK1G11.03977967
41ATR0.98835875
42SIK30.96075670
43STK390.95511419
44MAP2K60.93839539
45BCKDK0.93590846
46NME10.90565045
47STK160.89700663
48CSNK1G20.88914073
49MAPK130.88682295
50PAK30.88550755
51TXK0.86135088
52CASK0.85786025
53CSNK1A1L0.84938550
54TAOK20.77964950
55CCNB10.76651833
56DYRK20.75239419
57PINK10.73855417
58BRSK10.72192912
59ATM0.68923026
60CHEK20.66841135
61MAP3K40.66442989
62PNCK0.64448753
63MAPKAPK50.64165902
64DAPK10.62404662
65MUSK0.61209403
66STK30.60623075
67WNK40.59813907
68MAPKAPK30.58956463
69NLK0.57021032
70FER0.56839705
71PRKCE0.52923280
72PRKCI0.51276540
73PBK0.49603412
74PRKCG0.48017314
75PASK0.47162317
76TGFBR10.45872882
77AURKB0.44912082
78TIE10.39857925
79MINK10.39576080
80STK38L0.38717670
81CSNK2A10.37782588
82STK100.37388693
83GRK50.36439291
84MAP3K120.36082790
85CHEK10.34404093
86MELK0.34196083
87MARK30.33948304
88CSNK1A10.33509584
89MAP3K50.30959852
90PDK20.29265089
91PRKCQ0.28047028
92PHKG10.26882900
93PHKG20.26882900
94ADRBK10.26850401
95CSNK1D0.26668739
96STK40.25315351
97PRKDC0.23992916
98KDR0.23321278
99FGFR10.22299501
100CSNK2A20.21193955

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.19538876
2Protein export_Homo sapiens_hsa030603.31456360
3Non-homologous end-joining_Homo sapiens_hsa034503.29564015
4Homologous recombination_Homo sapiens_hsa034403.25399623
5Mismatch repair_Homo sapiens_hsa034303.05024782
6DNA replication_Homo sapiens_hsa030302.84716269
7Fanconi anemia pathway_Homo sapiens_hsa034602.73767853
8RNA polymerase_Homo sapiens_hsa030202.58487586
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44626152
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15081146
11One carbon pool by folate_Homo sapiens_hsa006702.11020762
12Propanoate metabolism_Homo sapiens_hsa006401.98785768
13Oxidative phosphorylation_Homo sapiens_hsa001901.97386238
14Selenocompound metabolism_Homo sapiens_hsa004501.90151008
15Basal transcription factors_Homo sapiens_hsa030221.88768502
16RNA degradation_Homo sapiens_hsa030181.87331176
17Base excision repair_Homo sapiens_hsa034101.84438847
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83458408
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78493284
20Nucleotide excision repair_Homo sapiens_hsa034201.75854373
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68507924
22RNA transport_Homo sapiens_hsa030131.68360933
23Parkinsons disease_Homo sapiens_hsa050121.67391639
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62865503
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.61610328
26Fatty acid elongation_Homo sapiens_hsa000621.59194181
27Butanoate metabolism_Homo sapiens_hsa006501.54574556
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54070657
29Phototransduction_Homo sapiens_hsa047441.53397871
30Pyrimidine metabolism_Homo sapiens_hsa002401.48396402
31Caffeine metabolism_Homo sapiens_hsa002321.38109230
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33823689
33Sulfur metabolism_Homo sapiens_hsa009201.32915613
34Spliceosome_Homo sapiens_hsa030401.32175558
35Cell cycle_Homo sapiens_hsa041101.24558999
36Purine metabolism_Homo sapiens_hsa002301.23263360
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22358536
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.19292940
39Steroid biosynthesis_Homo sapiens_hsa001001.18610932
40Vitamin B6 metabolism_Homo sapiens_hsa007501.13368814
41Huntingtons disease_Homo sapiens_hsa050161.07180028
42Nitrogen metabolism_Homo sapiens_hsa009101.05469367
43Peroxisome_Homo sapiens_hsa041461.05049182
44Tryptophan metabolism_Homo sapiens_hsa003801.02278985
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92410677
46Alzheimers disease_Homo sapiens_hsa050100.89595658
47p53 signaling pathway_Homo sapiens_hsa041150.84439793
48Pyruvate metabolism_Homo sapiens_hsa006200.82719232
49Glutathione metabolism_Homo sapiens_hsa004800.82441783
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80765189
51Ether lipid metabolism_Homo sapiens_hsa005650.78687791
52Oocyte meiosis_Homo sapiens_hsa041140.78313210
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76480220
54Linoleic acid metabolism_Homo sapiens_hsa005910.75912175
55Regulation of autophagy_Homo sapiens_hsa041400.74560200
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73590896
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73291484
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71674225
59Metabolic pathways_Homo sapiens_hsa011000.68864520
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68273229
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68021866
62beta-Alanine metabolism_Homo sapiens_hsa004100.67350285
63Fatty acid metabolism_Homo sapiens_hsa012120.65821795
64Primary immunodeficiency_Homo sapiens_hsa053400.63344145
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62726517
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62676365
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60453234
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58605399
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57791909
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55908068
71mRNA surveillance pathway_Homo sapiens_hsa030150.55312239
72Chemical carcinogenesis_Homo sapiens_hsa052040.52066210
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50471497
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50393718
75Retinol metabolism_Homo sapiens_hsa008300.47498741
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.47011104
77Folate biosynthesis_Homo sapiens_hsa007900.44987346
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44973775
79Fatty acid degradation_Homo sapiens_hsa000710.44580789
80Collecting duct acid secretion_Homo sapiens_hsa049660.43282161
81N-Glycan biosynthesis_Homo sapiens_hsa005100.42407262
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40098284
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.36462866
84Type I diabetes mellitus_Homo sapiens_hsa049400.36116892
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32882133
86Carbon metabolism_Homo sapiens_hsa012000.32447852
87Circadian rhythm_Homo sapiens_hsa047100.32131988
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.30776061
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28454703
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27353432
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26471317
92TGF-beta signaling pathway_Homo sapiens_hsa043500.25614236
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24910192
94Vitamin digestion and absorption_Homo sapiens_hsa049770.22269239
95Epstein-Barr virus infection_Homo sapiens_hsa051690.22036756
96Olfactory transduction_Homo sapiens_hsa047400.22027458
97Lysine degradation_Homo sapiens_hsa003100.20300140
98Nicotine addiction_Homo sapiens_hsa050330.17692196
99Hedgehog signaling pathway_Homo sapiens_hsa043400.17648356
100Glycerolipid metabolism_Homo sapiens_hsa005610.16243960

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