CNPY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cnpy1 is expressed in the midbrain-hindbrain (MHB) boundary in zebrafish, binds FGFR1 (MIM 136350), and plays a role in FGF signaling (Hirate and Okamoto, 2006 [PubMed 16488878]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.19210484
2cerebellar granule cell differentiation (GO:0021707)9.02088551
3cerebellar Purkinje cell differentiation (GO:0021702)6.76689073
4cell differentiation in hindbrain (GO:0021533)6.54835604
5neuronal action potential propagation (GO:0019227)6.14577094
6G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.08129262
7gamma-aminobutyric acid transport (GO:0015812)6.03249181
8locomotory exploration behavior (GO:0035641)5.58775315
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.54730933
10cellular potassium ion homeostasis (GO:0030007)5.48743220
11sodium ion export (GO:0071436)5.45374067
12behavioral response to nicotine (GO:0035095)5.39563703
13positive regulation of synapse maturation (GO:0090129)5.20940071
14ionotropic glutamate receptor signaling pathway (GO:0035235)5.18895147
15glutamate receptor signaling pathway (GO:0007215)5.17288199
16pyrimidine nucleobase catabolic process (GO:0006208)4.95523131
17synaptic transmission, glutamatergic (GO:0035249)4.84002091
18establishment of nucleus localization (GO:0040023)4.64446148
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.60692667
20neuron fate determination (GO:0048664)4.60552945
21neuromuscular process controlling posture (GO:0050884)4.55980323
22limb bud formation (GO:0060174)4.51582621
23neurotransmitter secretion (GO:0007269)4.47843904
24synaptic vesicle maturation (GO:0016188)4.47280137
25regulation of short-term neuronal synaptic plasticity (GO:0048172)4.42560036
26C4-dicarboxylate transport (GO:0015740)4.41853119
27layer formation in cerebral cortex (GO:0021819)4.30241130
28negative regulation of microtubule polymerization (GO:0031115)4.29467341
29multicellular organismal movement (GO:0050879)4.25373757
30musculoskeletal movement (GO:0050881)4.25373757
31vocalization behavior (GO:0071625)4.25222784
32gamma-aminobutyric acid signaling pathway (GO:0007214)4.22232199
33nonmotile primary cilium assembly (GO:0035058)4.20145609
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18361729
35negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.17019283
36dopaminergic neuron differentiation (GO:0071542)4.15285981
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.12407752
38neuron-neuron synaptic transmission (GO:0007270)4.11288731
39presynaptic membrane assembly (GO:0097105)4.09093867
40postsynaptic membrane organization (GO:0001941)4.05055267
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96320700
42long-term memory (GO:0007616)3.94654071
43nucleobase catabolic process (GO:0046113)3.93738500
44positive regulation of gastrulation (GO:2000543)3.93316808
45negative regulation of hormone biosynthetic process (GO:0032353)3.89062973
46negative regulation of hormone metabolic process (GO:0032351)3.89062973
47regulation of synapse maturation (GO:0090128)3.88427758
48somite development (GO:0061053)3.88143332
49synaptic vesicle exocytosis (GO:0016079)3.87081262
50neuromuscular process controlling balance (GO:0050885)3.83035762
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.78437296
52adult walking behavior (GO:0007628)3.78222110
53cell communication by electrical coupling (GO:0010644)3.74481344
54forebrain neuron differentiation (GO:0021879)3.73194460
55potassium ion import (GO:0010107)3.68499378
56glutamate secretion (GO:0014047)3.68020727
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67239202
58presynaptic membrane organization (GO:0097090)3.66909122
59retinal ganglion cell axon guidance (GO:0031290)3.65344130
60sequestering of actin monomers (GO:0042989)3.63347173
61microtubule depolymerization (GO:0007019)3.62650642
62regulation of synaptic vesicle exocytosis (GO:2000300)3.60884562
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.55738181
64innervation (GO:0060384)3.51335072
65transmission of nerve impulse (GO:0019226)3.50650760
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.50113506
67auditory behavior (GO:0031223)3.50025515
68neuronal stem cell maintenance (GO:0097150)3.49099666
69neurotransmitter transport (GO:0006836)3.47437215
70membrane depolarization during action potential (GO:0086010)3.47270805
71midbrain development (GO:0030901)3.46359612
72central nervous system myelination (GO:0022010)3.46183518
73axon ensheathment in central nervous system (GO:0032291)3.46183518
74synaptic vesicle endocytosis (GO:0048488)3.45764197
75neuron cell-cell adhesion (GO:0007158)3.42626854
76potassium ion homeostasis (GO:0055075)3.42188966
77regulation of mesenchymal cell apoptotic process (GO:2001053)3.42116141
78thalamus development (GO:0021794)3.42056111
79mechanosensory behavior (GO:0007638)3.41954296
80somite rostral/caudal axis specification (GO:0032525)3.41523232
81negative regulation of oligodendrocyte differentiation (GO:0048715)3.38113573
82exploration behavior (GO:0035640)3.36864139
83dendrite morphogenesis (GO:0048813)3.35016567
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31729997
85primitive streak formation (GO:0090009)3.31291725
86cellular sodium ion homeostasis (GO:0006883)3.30677445
87regulation of neurotransmitter levels (GO:0001505)3.28865616
88axonal fasciculation (GO:0007413)3.28148992
89regulation of development, heterochronic (GO:0040034)3.26740395
90cell migration in hindbrain (GO:0021535)3.25796781
91regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23017119
92mating behavior (GO:0007617)3.22762073
93positive regulation of oligodendrocyte differentiation (GO:0048714)3.21752966
94positive regulation of synapse assembly (GO:0051965)3.19062675
95startle response (GO:0001964)3.18205745
96synaptic transmission, cholinergic (GO:0007271)3.16641069
97positive regulation of potassium ion transmembrane transport (GO:1901381)3.14500385
98cerebellum development (GO:0021549)3.12124875
99positive regulation of embryonic development (GO:0040019)3.11776450
100dendritic spine morphogenesis (GO:0060997)3.10464430
101regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10438271
102positive regulation of dendritic spine morphogenesis (GO:0061003)3.09650490
103mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.09055862
104gonadal mesoderm development (GO:0007506)3.08895741
105establishment of protein localization to mitochondrial membrane (GO:0090151)3.08246932
106prepulse inhibition (GO:0060134)3.07311490
107regulation of timing of cell differentiation (GO:0048505)3.06560841
108membrane hyperpolarization (GO:0060081)3.05068842
109epithelial cilium movement (GO:0003351)3.04462912
110regulation of calcium ion-dependent exocytosis (GO:0017158)3.02015044
111regulation of synaptic vesicle transport (GO:1902803)2.98444186
112regulation of postsynaptic membrane potential (GO:0060078)2.97680278
113dorsal/ventral neural tube patterning (GO:0021904)2.97235186
114regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96577867
115synapse assembly (GO:0007416)2.95110524
116neuromuscular process (GO:0050905)2.94795517
117membrane depolarization (GO:0051899)2.94711376
118acidic amino acid transport (GO:0015800)2.94524398
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93850292
120protein localization to synapse (GO:0035418)2.92156286
121neuron fate specification (GO:0048665)2.91164403
122spinal cord development (GO:0021510)2.90246646
123hindbrain development (GO:0030902)2.90210425
124regulation of oligodendrocyte differentiation (GO:0048713)2.89527803
125regulation of centriole replication (GO:0046599)2.87699797
126membrane repolarization (GO:0086009)2.87115930
127neuronal action potential (GO:0019228)2.86851930
128L-glutamate transport (GO:0015813)2.86257242
129intraciliary transport (GO:0042073)2.83867452
130spinal cord motor neuron differentiation (GO:0021522)2.82992870
131central nervous system neuron differentiation (GO:0021953)2.82697258
132glycine transport (GO:0015816)2.82527891
133long term synaptic depression (GO:0060292)2.79713085
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78344182
135establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.77439399
136smoothened signaling pathway (GO:0007224)2.77277121
137positive regulation of sodium ion transmembrane transport (GO:1902307)2.77261515
138calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.77219592
139behavioral response to ethanol (GO:0048149)2.75484219
140negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.73787610
141neuromuscular synaptic transmission (GO:0007274)2.73057239
142heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.72904420
143regulation of hexokinase activity (GO:1903299)2.72459812
144regulation of glucokinase activity (GO:0033131)2.72459812
145regulation of glutamate receptor signaling pathway (GO:1900449)2.71811897
146chemosensory behavior (GO:0007635)2.71398038
147regulation of respiratory system process (GO:0044065)2.70565370
148inner ear receptor stereocilium organization (GO:0060122)2.70244230
149nephron epithelium morphogenesis (GO:0072088)2.68533372
150nephron tubule morphogenesis (GO:0072078)2.68533372
151cilium movement (GO:0003341)2.67891657
152regulation of cilium movement (GO:0003352)2.66699108
153negative regulation of glial cell differentiation (GO:0045686)2.66157298
154cell proliferation involved in metanephros development (GO:0072203)2.65078177
155spermatid nucleus differentiation (GO:0007289)2.64897678
156reflex (GO:0060004)2.63018563
157serotonin metabolic process (GO:0042428)2.62291409
158righting reflex (GO:0060013)2.57317709
159cilium organization (GO:0044782)2.56718683
160cell differentiation in spinal cord (GO:0021515)2.55213633
161neurotransmitter-gated ion channel clustering (GO:0072578)2.54942689
162male sex determination (GO:0030238)2.53490393
163cilium assembly (GO:0042384)2.52158715
164primary amino compound metabolic process (GO:1901160)2.51449580
165G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.51233327
166cerebral cortex radially oriented cell migration (GO:0021799)2.50427282
167establishment of planar polarity (GO:0001736)2.49278008
168establishment of tissue polarity (GO:0007164)2.49278008
169cranial nerve development (GO:0021545)2.48203752
170astrocyte differentiation (GO:0048708)2.47120254
171dopamine biosynthetic process (GO:0042416)2.46050950
172axonemal dynein complex assembly (GO:0070286)2.44207037
173reciprocal meiotic recombination (GO:0007131)2.44019997
174reciprocal DNA recombination (GO:0035825)2.44019997
175positive regulation of vascular permeability (GO:0043117)2.41892832
176neuron recognition (GO:0008038)2.41200523
177negative regulation of astrocyte differentiation (GO:0048712)2.41189506
178central nervous system projection neuron axonogenesis (GO:0021952)2.41169578
179protein K6-linked ubiquitination (GO:0085020)2.40710484
180adult feeding behavior (GO:0008343)2.40649609
181neurotransmitter catabolic process (GO:0042135)2.38828997
182cilium morphogenesis (GO:0060271)2.38386591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.56876895
2IKZF1_21737484_ChIP-ChIP_HCT116_Human3.06320700
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98772092
4* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.83102612
5DROSHA_22980978_ChIP-Seq_HELA_Human2.78786665
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69001396
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69001396
8REST_21632747_ChIP-Seq_MESCs_Mouse2.68428669
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54075884
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44982527
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.43763123
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37157518
13IGF1R_20145208_ChIP-Seq_DFB_Human2.36705055
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35065420
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.31533306
16* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.31431042
17VDR_22108803_ChIP-Seq_LS180_Human2.30804496
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.29035887
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.21159171
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21017791
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20319719
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17920601
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.17720586
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15843349
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.15395828
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.15001677
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11602488
28FUS_26573619_Chip-Seq_HEK293_Human2.07587182
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06615186
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.03123460
31AR_21572438_ChIP-Seq_LNCaP_Human2.02308475
32EWS_26573619_Chip-Seq_HEK293_Human2.02206661
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99415024
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96495816
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93950578
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.93525941
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.90469185
38TAF15_26573619_Chip-Seq_HEK293_Human1.83311051
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83176189
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77841959
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.77463144
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75690696
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74923263
44P300_19829295_ChIP-Seq_ESCs_Human1.74827754
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.72593936
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71959597
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70813598
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70504409
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69910722
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66783064
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65767232
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65479940
53KDM2B_26808549_Chip-Seq_K562_Human1.63592093
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.63362858
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.62851495
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61113790
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.60895419
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59131035
59* ZNF274_21170338_ChIP-Seq_K562_Hela1.57105969
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55994757
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55696046
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54119213
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53135079
64GBX2_23144817_ChIP-Seq_PC3_Human1.50061119
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.46505195
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45411550
67MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43934767
68* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43022294
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42396356
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42116372
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39660732
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38605173
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.38075083
74ER_23166858_ChIP-Seq_MCF-7_Human1.38005176
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37371792
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37291343
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.35845177
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35738554
79* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.35335832
80* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.35148349
81AR_19668381_ChIP-Seq_PC3_Human1.34020370
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33826136
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33509677
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.33349125
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.32523121
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31776430
87CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26103536
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25385614
89AR_25329375_ChIP-Seq_VCAP_Human1.25299971
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24094663
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.23995246
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.23617230
93TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22843248
94IRF1_19129219_ChIP-ChIP_H3396_Human1.22581550
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21214292
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.21158037
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20927228
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20400925
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20000274
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19075736
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.18029210
102MYC_18940864_ChIP-ChIP_HL60_Human1.14498209
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12795432
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.12513629
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.11939223
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11374883
107TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.10894800
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10570491
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10341470
110CBP_20019798_ChIP-Seq_JUKART_Human1.09303978
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09303978
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.08939721
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08888018
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07990444
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07677234
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06620222
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06330398
118KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05625006
119* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05521948
120SMAD4_21799915_ChIP-Seq_A2780_Human1.05493134
121* RUNX2_22187159_ChIP-Seq_PCA_Human1.05183988
122BCAT_22108803_ChIP-Seq_LS180_Human1.04949230
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.04540447
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03432689
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02351874
126PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01998247
127YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01691075
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01523779
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01523779
130NOTCH1_21737748_ChIP-Seq_TLL_Human1.01487231
131SOX9_26525672_Chip-Seq_HEART_Mouse1.01435245
132* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00788819
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00088581
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99974189
135SOX2_19829295_ChIP-Seq_ESCs_Human0.99400530
136NANOG_19829295_ChIP-Seq_ESCs_Human0.99400530
137ZNF263_19887448_ChIP-Seq_K562_Human0.99369322
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99263694
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99263694
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99263694
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98884706
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97487444
143GABP_17652178_ChIP-ChIP_JURKAT_Human0.96647340
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96502749
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96296944
146TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96256217
147FOXM1_23109430_ChIP-Seq_U2OS_Human0.96221732
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.96190488
149TP53_16413492_ChIP-PET_HCT116_Human0.94955903
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94420914
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.93319024
152CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92164334
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91790421
154SOX2_21211035_ChIP-Seq_LN229_Gbm0.91682753
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91260374
156STAT3_23295773_ChIP-Seq_U87_Human0.91004691
157* RNF2_27304074_Chip-Seq_NSC_Mouse0.89568388
158KDM2B_26808549_Chip-Seq_JURKAT_Human0.88785962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch4.83236603
2MP0004859_abnormal_synaptic_plasticity4.38134273
3MP0003136_yellow_coat_color4.26289754
4MP0003635_abnormal_synaptic_transmissio3.35828935
5MP0008569_lethality_at_weaning3.32888596
6MP0004145_abnormal_muscle_electrophysio3.22636306
7MP0000566_synostosis3.07124058
8MP0002184_abnormal_innervation2.83523724
9MP0001529_abnormal_vocalization2.80406168
10MP0002272_abnormal_nervous_system2.72836190
11MP0000569_abnormal_digit_pigmentation2.67453471
12MP0002067_abnormal_sensory_capabilities2.57475904
13MP0002064_seizures2.55447548
14MP0005423_abnormal_somatic_nervous2.46124409
15MP0003283_abnormal_digestive_organ2.42602536
16MP0004270_analgesia2.40245766
17MP0009745_abnormal_behavioral_response2.39316158
18MP0002734_abnormal_mechanical_nocicepti2.37061156
19MP0005171_absent_coat_pigmentation2.34925126
20MP0003011_delayed_dark_adaptation2.26395906
21MP0002063_abnormal_learning/memory/cond2.26125638
22MP0001440_abnormal_grooming_behavior2.23098613
23MP0002572_abnormal_emotion/affect_behav2.15473601
24MP0000778_abnormal_nervous_system2.12345867
25MP0001968_abnormal_touch/_nociception2.08080867
26MP0004885_abnormal_endolymph2.00955055
27MP0004742_abnormal_vestibular_system1.99923918
28MP0004142_abnormal_muscle_tone1.99172413
29MP0001486_abnormal_startle_reflex1.91666451
30MP0003632_abnormal_nervous_system1.90956361
31MP0002736_abnormal_nociception_after1.85272598
32MP0000955_abnormal_spinal_cord1.84742439
33MP0002557_abnormal_social/conspecific_i1.81140613
34MP0003787_abnormal_imprinting1.79391502
35MP0003880_abnormal_central_pattern1.78087135
36MP0005386_behavior/neurological_phenoty1.74636757
37MP0004924_abnormal_behavior1.74636757
38MP0004147_increased_porphyrin_level1.72784211
39MP0002735_abnormal_chemical_nociception1.72549977
40MP0005499_abnormal_olfactory_system1.66340755
41MP0005394_taste/olfaction_phenotype1.66340755
42MP0002653_abnormal_ependyma_morphology1.65701664
43MP0002152_abnormal_brain_morphology1.57618746
44MP0005253_abnormal_eye_physiology1.56637662
45MP0002066_abnormal_motor_capabilities/c1.51075992
46MP0003121_genomic_imprinting1.50846429
47MP0002733_abnormal_thermal_nociception1.48513382
48MP0005187_abnormal_penis_morphology1.48248302
49MP0002882_abnormal_neuron_morphology1.43427608
50MP0001501_abnormal_sleep_pattern1.38352561
51MP0003861_abnormal_nervous_system1.35249344
52MP0004133_heterotaxia1.34476974
53MP0004811_abnormal_neuron_physiology1.33111651
54MP0001970_abnormal_pain_threshold1.32701137
55MP0009379_abnormal_foot_pigmentation1.29552379
56MP0003937_abnormal_limbs/digits/tail_de1.28432824
57MP0002277_abnormal_respiratory_mucosa1.27864595
58MP0000049_abnormal_middle_ear1.27515277
59MP0003122_maternal_imprinting1.25534592
60MP0002282_abnormal_trachea_morphology1.24634653
61MP0001986_abnormal_taste_sensitivity1.22441557
62MP0003890_abnormal_embryonic-extraembry1.21367233
63MP0005377_hearing/vestibular/ear_phenot1.18675619
64MP0003878_abnormal_ear_physiology1.18675619
65MP0000647_abnormal_sebaceous_gland1.17705245
66MP0006292_abnormal_olfactory_placode1.17169014
67MP0001286_abnormal_eye_development1.14971810
68MP0006072_abnormal_retinal_apoptosis1.13926847
69MP0002089_abnormal_postnatal_growth/wei1.12646192
70MP0008789_abnormal_olfactory_epithelium1.11767191
71MP0002102_abnormal_ear_morphology1.11344494
72MP0005084_abnormal_gallbladder_morpholo1.10966413
73MP0003631_nervous_system_phenotype1.10453398
74MP0003137_abnormal_impulse_conducting1.10042175
75MP0003938_abnormal_ear_development1.09369356
76MP0000537_abnormal_urethra_morphology1.08493366
77MP0002928_abnormal_bile_duct1.08228864
78MP0002938_white_spotting1.06474444
79MP0001905_abnormal_dopamine_level1.05581711
80MP0005391_vision/eye_phenotype1.04604661
81MP0001485_abnormal_pinna_reflex1.04188128
82MP0002095_abnormal_skin_pigmentation1.00359379
83MP0002752_abnormal_somatic_nervous0.99641772
84MP0005195_abnormal_posterior_eye0.98567109
85MP0004215_abnormal_myocardial_fiber0.95808548
86MP0001502_abnormal_circadian_rhythm0.95422532
87MP0004858_abnormal_nervous_system0.94851568
88MP0003329_amyloid_beta_deposits0.94478296
89MP0001293_anophthalmia0.94010149
90MP0008872_abnormal_physiological_respon0.94007232
91MP0002233_abnormal_nose_morphology0.90773599
92MP0001324_abnormal_eye_pigmentation0.90606638
93MP0005646_abnormal_pituitary_gland0.90139143
94MP0001984_abnormal_olfaction0.89695771
95MP0003195_calcinosis0.89513426
96MP0005083_abnormal_biliary_tract0.87424595
97MP0000383_abnormal_hair_follicle0.85901083
98MP0003755_abnormal_palate_morphology0.84965755
99MP0005503_abnormal_tendon_morphology0.82968452
100MP0006276_abnormal_autonomic_nervous0.82881862
101MP0003119_abnormal_digestive_system0.82689464
102MP0002160_abnormal_reproductive_system0.82095854
103MP0002909_abnormal_adrenal_gland0.82026277
104MP0000534_abnormal_ureter_morphology0.81411937
105MP0001963_abnormal_hearing_physiology0.80539108
106MP0001299_abnormal_eye_distance/0.79857096
107MP0010769_abnormal_survival0.79506242
108MP0002229_neurodegeneration0.78761017
109MP0002697_abnormal_eye_size0.78574672
110MP0002837_dystrophic_cardiac_calcinosis0.78282786
111MP0000026_abnormal_inner_ear0.77176958
112MP0010768_mortality/aging0.76960743
113MP0003633_abnormal_nervous_system0.76937543
114MP0005645_abnormal_hypothalamus_physiol0.74663053
115MP0010770_preweaning_lethality0.74310404
116MP0002082_postnatal_lethality0.74310404
117MP0004043_abnormal_pH_regulation0.73772641
118MP0008877_abnormal_DNA_methylation0.73662021
119MP0001188_hyperpigmentation0.72683822
120MP0002751_abnormal_autonomic_nervous0.71750526
121MP0004233_abnormal_muscle_weight0.70763628
122MP0002234_abnormal_pharynx_morphology0.70215032
123MP0005623_abnormal_meninges_morphology0.66489868
124MP0008995_early_reproductive_senescence0.62323763
125MP0002638_abnormal_pupillary_reflex0.62058983
126MP0003698_abnormal_male_reproductive0.61860994
127MP0002249_abnormal_larynx_morphology0.61050257
128MP0002069_abnormal_eating/drinking_beha0.60952383
129MP0002084_abnormal_developmental_patter0.60718800
130MP0003634_abnormal_glial_cell0.60549579
131MP0001943_abnormal_respiration0.60537728
132MP0000631_abnormal_neuroendocrine_gland0.60318746
133MP0005551_abnormal_eye_electrophysiolog0.60279070
134MP0000467_abnormal_esophagus_morphology0.60050851

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)6.73928738
2Progressive cerebellar ataxia (HP:0002073)6.39369177
3Gaze-evoked nystagmus (HP:0000640)5.04187344
4Visual hallucinations (HP:0002367)4.97215993
5Impaired smooth pursuit (HP:0007772)4.81851456
6Abnormality of ocular smooth pursuit (HP:0000617)4.53165357
7Scanning speech (HP:0002168)4.51108792
8Dysmetric saccades (HP:0000641)4.40219145
9Dysdiadochokinesis (HP:0002075)4.26257268
10Focal seizures (HP:0007359)4.23886123
11Atonic seizures (HP:0010819)4.07595303
12Abnormality of the lower motor neuron (HP:0002366)4.01425353
13Tetraplegia (HP:0002445)4.00264835
14Hemiplegia (HP:0002301)3.98822465
15Type II lissencephaly (HP:0007260)3.98245253
16Focal motor seizures (HP:0011153)3.97551686
17Febrile seizures (HP:0002373)3.90912745
18Intention tremor (HP:0002080)3.88558837
19True hermaphroditism (HP:0010459)3.88226360
20Oligodactyly (hands) (HP:0001180)3.84863643
21Broad-based gait (HP:0002136)3.79585444
22Myokymia (HP:0002411)3.73365906
23Hemiparesis (HP:0001269)3.37241942
24Genetic anticipation (HP:0003743)3.32851950
25Postural tremor (HP:0002174)3.29949015
26Diplopia (HP:0000651)3.26271405
27Abnormality of binocular vision (HP:0011514)3.26271405
28Horizontal nystagmus (HP:0000666)3.24693522
29Annular pancreas (HP:0001734)3.21823466
30Pancreatic cysts (HP:0001737)3.16260392
31Absence seizures (HP:0002121)3.14468572
32Truncal ataxia (HP:0002078)3.13269500
33Dysmetria (HP:0001310)3.09975838
34Pancreatic fibrosis (HP:0100732)3.09080810
35Retinal dysplasia (HP:0007973)3.08792465
36Septo-optic dysplasia (HP:0100842)3.06653283
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.96574981
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.96574981
39Amyotrophic lateral sclerosis (HP:0007354)2.88226957
40Status epilepticus (HP:0002133)2.85900597
41Poor eye contact (HP:0000817)2.85518748
42Concave nail (HP:0001598)2.85441698
43Oligodactyly (HP:0012165)2.84765460
44Abnormality of midbrain morphology (HP:0002418)2.80046203
45Molar tooth sign on MRI (HP:0002419)2.80046203
46Lissencephaly (HP:0001339)2.77602054
47Medial flaring of the eyebrow (HP:0010747)2.74803475
48Epileptic encephalopathy (HP:0200134)2.74287055
49Congenital, generalized hypertrichosis (HP:0004540)2.72976137
50Anophthalmia (HP:0000528)2.69201912
51Cerebellar dysplasia (HP:0007033)2.65599394
52Dialeptic seizures (HP:0011146)2.62752915
53Gait imbalance (HP:0002141)2.56251956
54Limb ataxia (HP:0002070)2.55554412
55Nephronophthisis (HP:0000090)2.54747309
56Morphological abnormality of the pyramidal tract (HP:0002062)2.54177853
57Impaired social interactions (HP:0000735)2.53274258
58Abnormal social behavior (HP:0012433)2.53274258
59Limb dystonia (HP:0002451)2.52815114
60Patellar aplasia (HP:0006443)2.52170799
61Optic nerve hypoplasia (HP:0000609)2.49901034
62Intestinal atresia (HP:0011100)2.49699784
63Agitation (HP:0000713)2.48752656
64Abnormality of saccadic eye movements (HP:0000570)2.47203325
65Congenital primary aphakia (HP:0007707)2.45421123
66Pointed chin (HP:0000307)2.45087792
67Ventricular fibrillation (HP:0001663)2.37722619
68Abnormal respiratory epithelium morphology (HP:0012253)2.37591926
69Abnormal respiratory motile cilium morphology (HP:0005938)2.37591926
70Sclerocornea (HP:0000647)2.36898619
71Abnormality of the renal medulla (HP:0100957)2.35592244
72Renal cortical cysts (HP:0000803)2.33640302
73Lower limb asymmetry (HP:0100559)2.33581077
74Abnormality of the renal cortex (HP:0011035)2.33080932
75Abnormality of the labia minora (HP:0012880)2.33024687
76Polyphagia (HP:0002591)2.32979542
77Trigonocephaly (HP:0000243)2.31952582
78Maternal diabetes (HP:0009800)2.31415478
79Nephrogenic diabetes insipidus (HP:0009806)2.29930134
80Aplasia/Hypoplasia of the patella (HP:0006498)2.29476430
81Congenital sensorineural hearing impairment (HP:0008527)2.29380869
82Hyperventilation (HP:0002883)2.27602601
83Generalized tonic-clonic seizures (HP:0002069)2.25847114
84Gait ataxia (HP:0002066)2.25712205
85Abnormal ciliary motility (HP:0012262)2.22746517
86Short 4th metacarpal (HP:0010044)2.18766768
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.18766768
88Birth length less than 3rd percentile (HP:0003561)2.17064593
89Aplasia/Hypoplasia of the tibia (HP:0005772)2.17007171
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15639132
91Gastrointestinal atresia (HP:0002589)2.15615200
92Bilateral microphthalmos (HP:0007633)2.15401540
93Hand muscle atrophy (HP:0009130)2.15221854
94Aqueductal stenosis (HP:0002410)2.15148947
95Specific learning disability (HP:0001328)2.14788370
96Genital tract atresia (HP:0001827)2.14311927
97Tubulointerstitial nephritis (HP:0001970)2.12637710
98Postaxial hand polydactyly (HP:0001162)2.12288943
99Short tibia (HP:0005736)2.11469649
100Hypothermia (HP:0002045)2.10424959
101Large for gestational age (HP:0001520)2.09676398
102Shallow orbits (HP:0000586)2.08556242
103Male pseudohermaphroditism (HP:0000037)2.08515508
104Postaxial foot polydactyly (HP:0001830)2.07235564
105Vaginal atresia (HP:0000148)2.03981648
106Chronic hepatic failure (HP:0100626)2.03395286
107Abnormality of the corticospinal tract (HP:0002492)2.02854790
108Neoplasm of the heart (HP:0100544)2.01399950
109Depression (HP:0000716)1.99968154
110Congenital stationary night blindness (HP:0007642)1.99126002
111Myotonia (HP:0002486)1.98834377
112Pendular nystagmus (HP:0012043)1.98463074
113Cystic liver disease (HP:0006706)1.97046663
114Anencephaly (HP:0002323)1.96458563
115Occipital encephalocele (HP:0002085)1.96389191
116Absent septum pellucidum (HP:0001331)1.93949290
117Insomnia (HP:0100785)1.92770904
118Abnormal number of erythroid precursors (HP:0012131)1.92019600
119Labial hypoplasia (HP:0000066)1.91026717
120Midline defect of the nose (HP:0004122)1.90925452
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88727792
122Abolished electroretinogram (ERG) (HP:0000550)1.88094307
123Acute necrotizing encephalopathy (HP:0006965)1.87854505
124Stereotypic behavior (HP:0000733)1.87791719
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.87238485
126Pachygyria (HP:0001302)1.87104789
127Abnormal respiratory motile cilium physiology (HP:0012261)1.85203647
128Abnormality of the 4th metacarpal (HP:0010012)1.84191385
129Hypoplastic nipples (HP:0002557)1.83802538
130Congenital hepatic fibrosis (HP:0002612)1.79697594
131Supranuclear gaze palsy (HP:0000605)1.78930549
132Rib fusion (HP:0000902)1.78883622
133Prominent supraorbital ridges (HP:0000336)1.78807377
134Hyperacusis (HP:0010780)1.78427897
135Narrow nasal bridge (HP:0000446)1.77304085
136Calf muscle hypertrophy (HP:0008981)1.77082139
137Optic disc pallor (HP:0000543)1.76920326
138Renovascular hypertension (HP:0100817)1.76848429
139Drooling (HP:0002307)1.76472814
140Excessive salivation (HP:0003781)1.76472814
141Supernumerary bones of the axial skeleton (HP:0009144)1.76415979
142Hypoplasia of the pons (HP:0012110)1.75750176
143Neuronal loss in central nervous system (HP:0002529)1.75101746
144Pseudobulbar signs (HP:0002200)1.74933621
145Attenuation of retinal blood vessels (HP:0007843)1.74520221
146Incomplete penetrance (HP:0003829)1.73862323
147Preaxial hand polydactyly (HP:0001177)1.73795037
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.73566413
149Abnormal number of incisors (HP:0011064)1.71940697
150Split foot (HP:0001839)1.71463464
151Hypoplastic female external genitalia (HP:0012815)1.70110329
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.69717432
153Absent/shortened dynein arms (HP:0200106)1.69717432
154Supernumerary spleens (HP:0009799)1.69557737
155Elfin facies (HP:0004428)1.69192972
156Fibular hypoplasia (HP:0003038)1.69187703
157Holoprosencephaly (HP:0001360)1.68504926
158Fetal akinesia sequence (HP:0001989)1.67978538
159Anosmia (HP:0000458)1.67872329
160Anteriorly placed anus (HP:0001545)1.67604210
161Confusion (HP:0001289)1.67570289
162Mask-like facies (HP:0000298)1.67004962
163Mutism (HP:0002300)1.66778110
164Abnormality of the diencephalon (HP:0010662)1.65543799
165Esophageal atresia (HP:0002032)1.63976097
166Anxiety (HP:0000739)1.63796430
167Choroideremia (HP:0001139)1.63406720
168Slow progression (HP:0003677)1.62473009
169Spastic gait (HP:0002064)1.62421808
170Restlessness (HP:0000711)1.61046192
171Bundle branch block (HP:0011710)1.60906073
172Pelvic girdle muscle weakness (HP:0003749)1.60675089
173Sacral dimple (HP:0000960)1.59619869
174Stenosis of the external auditory canal (HP:0000402)1.58612063
175Abnormal eating behavior (HP:0100738)1.58544473
176Spastic tetraplegia (HP:0002510)1.58250737
177Hemivertebrae (HP:0002937)1.57971368
178Renal duplication (HP:0000075)1.56034983
179Obsessive-compulsive behavior (HP:0000722)1.56017725
180Increased nuchal translucency (HP:0010880)1.55045276
181Impaired vibration sensation in the lower limbs (HP:0002166)1.55002359
182Neoplasm of the oral cavity (HP:0100649)1.54143520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK23.97399774
2RIPK13.82936541
3MAPK153.58899220
4INSRR3.20050757
5WEE12.95510184
6NTRK32.81720751
7WNK12.77953320
8NTRK22.65213996
9MAP3K92.63103101
10ERBB32.52300731
11TSSK62.52227102
12CDK192.51071609
13MAP3K42.49892782
14WNK32.48042900
15PNCK2.45503863
16MINK12.30796416
17MARK12.30355169
18STK382.23761730
19PAK62.14020568
20KSR12.13566120
21CAMKK12.09986144
22CASK2.08503185
23MAP2K41.95357950
24MKNK21.87991966
25TYRO31.86525698
26DYRK21.82966992
27MKNK11.78058306
28VRK11.75211880
29ADRBK21.66539785
30MAP4K21.65788516
31FRK1.60555530
32NEK11.55474478
33EPHB21.54397811
34MAP2K71.52595547
35UHMK11.42571716
36CCNB11.38653797
37WNK41.36369686
38PASK1.32733346
39CDK181.31677577
40CDK151.30801505
41SIK21.30756670
42ALK1.30682089
43EPHA41.28968942
44STK111.26050162
45CDK11A1.20260929
46PRPF4B1.18756857
47PAK31.18641212
48PRKCG1.16577537
49DAPK21.13878894
50BCR1.10201649
51CAMK41.09009092
52SIK31.06247618
53STK391.03650370
54DYRK1A1.03476688
55CDK141.03149001
56MAPK131.01795012
57KSR21.00859402
58PTK61.00521445
59GRK11.00148960
60BMPR20.98035061
61ADRBK10.96581171
62SRPK10.94586080
63NEK20.93688023
64TGFBR10.93327556
65SGK20.92983413
66CDC42BPA0.90325138
67OXSR10.90233383
68BMPR1B0.90175942
69SGK4940.88595031
70SGK2230.88595031
71BRSK20.87139251
72TRIM280.86751103
73CDK50.85896017
74PLK20.84607006
75TTK0.83910668
76CAMK1G0.81873778
77BRD40.81656865
78NUAK10.80950110
79ROCK20.80824948
80CDC70.80257058
81CAMK10.80243020
82GRK50.80155356
83SGK30.77381996
84CAMK2G0.75962905
85ICK0.71506056
86PRKDC0.71149955
87CSNK1E0.69602733
88CDK30.69403959
89LATS20.67020239
90PTK20.64773559
91PKN10.64106207
92PRKG10.63046564
93RET0.62970383
94PINK10.62876559
95CSNK1G20.62874047
96EEF2K0.62004018
97CSNK1G30.61447936
98VRK20.60830296
99CAMK2B0.60680745
100CSNK1G10.60636679
101PAK40.60636173
102TLK10.59685962
103CHEK20.59418547
104MAPKAPK50.59265574
105MUSK0.58848794
106CDK20.58754097
107PHKG20.57671270
108PHKG10.57671270
109CSNK1A1L0.56585927
110CDK10.56543410
111ERBB20.56105435
112PRKCE0.55389199
113RPS6KA30.55321796
114TNIK0.54270806
115BUB10.54087038
116PTK2B0.53351781
117RPS6KA50.52533783
118RPS6KA40.52398370
119AKT30.52303000
120PLK30.51780415
121BCKDK0.51264206
122MAPK90.50011445
123MAPK100.49411308
124PLK10.48597753
125YES10.48498763
126LATS10.48359156
127STK38L0.48215229
128GSK3B0.47764007
129HIPK20.47409677
130OBSCN0.47218238
131SGK10.47030246
132DYRK30.46799265
133CSNK1D0.46320752
134PRKACA0.45128819
135CAMK2D0.44799527
136EPHA30.44583418
137IRAK10.44439620
138FYN0.43744115
139CDK120.43509930
140PLK40.43504197
141MAPK80.43241382
142ERBB40.42525947
143DYRK1B0.42413847
144CAMK2A0.41604550
145MAPK140.40811985
146MAP3K60.40401525
147MARK20.40089478
148CHEK10.38997851
149PRKACB0.38544097
150CAMK1D0.35082927
151ROCK10.31850541
152TAF10.31385925
153CSNK1A10.31345617
154CHUK0.29458451
155TAOK30.27852106
156MAP2K20.27689406
157PRKCZ0.23414887

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.97450386
2Glutamatergic synapse_Homo sapiens_hsa047243.27390135
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.19931190
4Long-term depression_Homo sapiens_hsa047303.08140661
5Long-term potentiation_Homo sapiens_hsa047203.06967904
6Maturity onset diabetes of the young_Homo sapiens_hsa049503.02734965
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95588443
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94974410
9Taste transduction_Homo sapiens_hsa047422.60660894
10Circadian entrainment_Homo sapiens_hsa047132.60259900
11Synaptic vesicle cycle_Homo sapiens_hsa047212.58976513
12GABAergic synapse_Homo sapiens_hsa047272.58095038
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.43947561
14Butanoate metabolism_Homo sapiens_hsa006502.43057809
15Protein export_Homo sapiens_hsa030602.26459241
16Steroid biosynthesis_Homo sapiens_hsa001002.24331120
17Ribosome_Homo sapiens_hsa030102.20813991
18Phototransduction_Homo sapiens_hsa047442.16866648
19Oxidative phosphorylation_Homo sapiens_hsa001902.16849806
20Morphine addiction_Homo sapiens_hsa050322.11196689
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05708629
22Amphetamine addiction_Homo sapiens_hsa050312.03804649
23Parkinsons disease_Homo sapiens_hsa050122.03001893
24Salivary secretion_Homo sapiens_hsa049702.02851659
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98118245
26Linoleic acid metabolism_Homo sapiens_hsa005911.82836970
27Dopaminergic synapse_Homo sapiens_hsa047281.80423939
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76940820
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70360043
30Gastric acid secretion_Homo sapiens_hsa049711.69562642
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.69192638
32Type II diabetes mellitus_Homo sapiens_hsa049301.66874894
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.65034577
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63906639
35Insulin secretion_Homo sapiens_hsa049111.55386874
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.51965056
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51846702
38Propanoate metabolism_Homo sapiens_hsa006401.48111819
39Cholinergic synapse_Homo sapiens_hsa047251.46879719
40Oocyte meiosis_Homo sapiens_hsa041141.46569655
41Fanconi anemia pathway_Homo sapiens_hsa034601.42087312
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38585378
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35175168
44Estrogen signaling pathway_Homo sapiens_hsa049151.34837146
45Olfactory transduction_Homo sapiens_hsa047401.33999640
46Huntingtons disease_Homo sapiens_hsa050161.33986977
47Oxytocin signaling pathway_Homo sapiens_hsa049211.32231845
48Thyroid hormone synthesis_Homo sapiens_hsa049181.31799693
49Gap junction_Homo sapiens_hsa045401.26158157
50Tryptophan metabolism_Homo sapiens_hsa003801.25965498
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25488667
52GnRH signaling pathway_Homo sapiens_hsa049121.24415629
53Alzheimers disease_Homo sapiens_hsa050101.21736095
54Calcium signaling pathway_Homo sapiens_hsa040201.21078076
55Serotonergic synapse_Homo sapiens_hsa047261.20608252
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20402346
57Ether lipid metabolism_Homo sapiens_hsa005651.20009946
58Pancreatic secretion_Homo sapiens_hsa049721.19833840
59Basal cell carcinoma_Homo sapiens_hsa052171.18035564
60Hedgehog signaling pathway_Homo sapiens_hsa043401.17172517
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16511831
62Basal transcription factors_Homo sapiens_hsa030221.14711074
63cAMP signaling pathway_Homo sapiens_hsa040241.13699144
64Selenocompound metabolism_Homo sapiens_hsa004501.07650402
65Inositol phosphate metabolism_Homo sapiens_hsa005621.06067582
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04947029
67RNA polymerase_Homo sapiens_hsa030201.04715637
68Melanogenesis_Homo sapiens_hsa049161.04505989
69Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00619991
70Histidine metabolism_Homo sapiens_hsa003400.98799947
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97359286
72Cardiac muscle contraction_Homo sapiens_hsa042600.97328377
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96047935
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95692769
75mRNA surveillance pathway_Homo sapiens_hsa030150.94243888
76RNA degradation_Homo sapiens_hsa030180.93159083
77Peroxisome_Homo sapiens_hsa041460.92990691
78Sulfur relay system_Homo sapiens_hsa041220.92601445
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92262981
80Cocaine addiction_Homo sapiens_hsa050300.89148710
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88972515
82Retinol metabolism_Homo sapiens_hsa008300.88807187
83Homologous recombination_Homo sapiens_hsa034400.87436436
84Nitrogen metabolism_Homo sapiens_hsa009100.86439120
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.86324905
86Renin secretion_Homo sapiens_hsa049240.86214933
87Axon guidance_Homo sapiens_hsa043600.85827169
88mTOR signaling pathway_Homo sapiens_hsa041500.85765897
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85329434
90Choline metabolism in cancer_Homo sapiens_hsa052310.85260319
91Arachidonic acid metabolism_Homo sapiens_hsa005900.84939392
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83278794
93Notch signaling pathway_Homo sapiens_hsa043300.82124289
94beta-Alanine metabolism_Homo sapiens_hsa004100.81960204
95Bile secretion_Homo sapiens_hsa049760.81486716
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80246767
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.79927691
98Hippo signaling pathway_Homo sapiens_hsa043900.79777567
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79504101
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78463178
101Fat digestion and absorption_Homo sapiens_hsa049750.74561462
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74068112
103Dorso-ventral axis formation_Homo sapiens_hsa043200.72556782
104ErbB signaling pathway_Homo sapiens_hsa040120.70222915
105Glioma_Homo sapiens_hsa052140.69917945
106Wnt signaling pathway_Homo sapiens_hsa043100.68981608
107Chemical carcinogenesis_Homo sapiens_hsa052040.67458660
108TGF-beta signaling pathway_Homo sapiens_hsa043500.66758613
109Non-homologous end-joining_Homo sapiens_hsa034500.66041253
110Regulation of autophagy_Homo sapiens_hsa041400.65572891
111Phenylalanine metabolism_Homo sapiens_hsa003600.61787583
112Alcoholism_Homo sapiens_hsa050340.61619717
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59555956
114Endometrial cancer_Homo sapiens_hsa052130.56523112
115MAPK signaling pathway_Homo sapiens_hsa040100.56061221
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55982936
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53985921
118Mineral absorption_Homo sapiens_hsa049780.53890629
119Caffeine metabolism_Homo sapiens_hsa002320.53740043
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53661227
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53085399
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52985110
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.52129313
124Tyrosine metabolism_Homo sapiens_hsa003500.51995839
125VEGF signaling pathway_Homo sapiens_hsa043700.51676345
126Proteoglycans in cancer_Homo sapiens_hsa052050.50995073
127Folate biosynthesis_Homo sapiens_hsa007900.50799912
128Circadian rhythm_Homo sapiens_hsa047100.50672071
129Mismatch repair_Homo sapiens_hsa034300.50643318
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.48889463
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.48510908
132Tight junction_Homo sapiens_hsa045300.48382049
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47037076
134Spliceosome_Homo sapiens_hsa030400.46608078
135Colorectal cancer_Homo sapiens_hsa052100.46477658
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45301849
137Dilated cardiomyopathy_Homo sapiens_hsa054140.45161086
138Metabolic pathways_Homo sapiens_hsa011000.42893075
139Purine metabolism_Homo sapiens_hsa002300.42719154
140Arginine and proline metabolism_Homo sapiens_hsa003300.42492591
141Non-small cell lung cancer_Homo sapiens_hsa052230.42268970
142One carbon pool by folate_Homo sapiens_hsa006700.41374317
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40622646
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40316617
145Glycerolipid metabolism_Homo sapiens_hsa005610.40090118
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39114717
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37110996
148Glucagon signaling pathway_Homo sapiens_hsa049220.36763920
149Renal cell carcinoma_Homo sapiens_hsa052110.35861696
150ABC transporters_Homo sapiens_hsa020100.35684195
151Fatty acid elongation_Homo sapiens_hsa000620.34551785
152Rap1 signaling pathway_Homo sapiens_hsa040150.34076500
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34011659
154Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33234723
155Lysine degradation_Homo sapiens_hsa003100.30279269
156FoxO signaling pathway_Homo sapiens_hsa040680.27698189
157Sphingolipid signaling pathway_Homo sapiens_hsa040710.25085659
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24396214
159RNA transport_Homo sapiens_hsa030130.24288697
160Ovarian steroidogenesis_Homo sapiens_hsa049130.23975713
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23479223
162Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21820013
163AMPK signaling pathway_Homo sapiens_hsa041520.19471340

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