CNPY3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrough transcription occurs between this locus and the downstream GNMT (glycine N-methyltransferase) gene and is represented with GeneID:107080644. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.44272540
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.44272540
3antigen processing and presentation of endogenous antigen (GO:0019883)5.14539770
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.97119592
5negative regulation of cell killing (GO:0031342)4.97119592
6detection of other organism (GO:0098543)4.63077936
7detection of bacterium (GO:0016045)4.58969398
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35839744
9negative regulation of phagocytosis (GO:0050765)4.15399741
10disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.98042716
11killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.98042716
12B cell mediated immunity (GO:0019724)3.88373436
13regulation of mast cell degranulation (GO:0043304)3.87883194
14cellular extravasation (GO:0045123)3.87126681
15neutrophil activation (GO:0042119)3.86047385
16regulation of interferon-beta biosynthetic process (GO:0045357)3.84493137
17leukocyte aggregation (GO:0070486)3.81031613
18regulation of B cell receptor signaling pathway (GO:0050855)3.78527165
19detection of external biotic stimulus (GO:0098581)3.76742104
20regulation of gamma-delta T cell activation (GO:0046643)3.71750274
21regulation of myeloid leukocyte mediated immunity (GO:0002886)3.67818978
22granulocyte activation (GO:0036230)3.65221841
23myeloid cell activation involved in immune response (GO:0002275)3.59706455
24response to host immune response (GO:0052572)3.57812845
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.57812845
26pentose-phosphate shunt (GO:0006098)3.54337081
27regulation of mast cell activation involved in immune response (GO:0033006)3.52923582
28Golgi transport vesicle coating (GO:0048200)3.49643015
29COPI coating of Golgi vesicle (GO:0048205)3.49643015
30antigen processing and presentation via MHC class Ib (GO:0002475)3.48947354
31regulation of leukocyte degranulation (GO:0043300)3.48406982
32response to muramyl dipeptide (GO:0032495)3.45847248
33positive thymic T cell selection (GO:0045059)3.43483988
34positive regulation of mast cell activation (GO:0033005)3.41482906
35microglial cell activation (GO:0001774)3.41438386
36detection of biotic stimulus (GO:0009595)3.38965238
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37533667
38positive regulation of B cell differentiation (GO:0045579)3.35071630
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34313287
40type I interferon signaling pathway (GO:0060337)3.27762956
41cellular response to type I interferon (GO:0071357)3.27762956
42DNA deamination (GO:0045006)3.27554572
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.27378703
44interferon-gamma-mediated signaling pathway (GO:0060333)3.26523422
45alpha-linolenic acid metabolic process (GO:0036109)3.24243306
46response to type I interferon (GO:0034340)3.23847845
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23841557
48response to host (GO:0075136)3.23841557
49response to host defenses (GO:0052200)3.23841557
50respiratory burst (GO:0045730)3.23759452
51valine metabolic process (GO:0006573)3.23644354
52regulation of gamma-delta T cell differentiation (GO:0045586)3.22969036
53detection of molecule of bacterial origin (GO:0032490)3.22548513
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22504286
55response to protozoan (GO:0001562)3.21419618
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.20092945
57regulation of mast cell activation (GO:0033003)3.19874880
58negative regulation of leukocyte mediated immunity (GO:0002704)3.19516820
59protein retention in ER lumen (GO:0006621)3.18402619
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18118057
61positive regulation of mast cell degranulation (GO:0043306)3.13745389
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.13745389
63NADPH regeneration (GO:0006740)3.13473155
64macrophage activation (GO:0042116)3.13429247
65negative regulation of granulocyte differentiation (GO:0030853)3.12079364
66ribosomal small subunit assembly (GO:0000028)3.11675031
67disruption of cells of other organism (GO:0044364)3.11006458
68killing of cells of other organism (GO:0031640)3.11006458
69leukocyte degranulation (GO:0043299)3.09945112
70positive regulation of gamma-delta T cell activation (GO:0046645)3.06129593
71neutrophil mediated immunity (GO:0002446)3.03756436
72positive regulation of antigen processing and presentation (GO:0002579)3.03384042
73low-density lipoprotein particle remodeling (GO:0034374)3.02962318
74positive regulation by symbiont of host defense response (GO:0052509)3.01355130
75modulation by symbiont of host defense response (GO:0052031)3.01355130
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01355130
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01355130
78positive regulation by organism of defense response of other organism involved in symbiotic interact3.01355130
79modulation by symbiont of host immune response (GO:0052553)3.01355130
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.00075826
81L-phenylalanine metabolic process (GO:0006558)3.00075826
82mannose metabolic process (GO:0006013)2.99220622
83lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97582331
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96749363
85NIK/NF-kappaB signaling (GO:0038061)2.92905564
86neutrophil activation involved in immune response (GO:0002283)2.92757665
87leukocyte migration involved in inflammatory response (GO:0002523)2.92363213
88immunoglobulin mediated immune response (GO:0016064)2.91114890
89negative thymic T cell selection (GO:0045060)2.91060063
90negative regulation of innate immune response (GO:0045824)2.90869425
91peptidyl-glutamic acid carboxylation (GO:0017187)2.87742463
92protein carboxylation (GO:0018214)2.87742463
93regulation of regulated secretory pathway (GO:1903305)2.87178338
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87147678
95positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.85052540
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84764532
97triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.83643867
98regulation of B cell differentiation (GO:0045577)2.83625529
99peptide catabolic process (GO:0043171)2.83617468
100negative regulation of interleukin-12 production (GO:0032695)2.83427955
101regulation of superoxide anion generation (GO:0032928)2.81703845
102positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.81344962
103sulfur amino acid catabolic process (GO:0000098)2.79351076
104high-density lipoprotein particle remodeling (GO:0034375)2.79306850
105negative regulation of cytokine production involved in immune response (GO:0002719)2.79119440
106negative T cell selection (GO:0043383)2.75497745
107polyketide metabolic process (GO:0030638)2.75483269
108doxorubicin metabolic process (GO:0044598)2.75483269
109daunorubicin metabolic process (GO:0044597)2.75483269
110macrophage activation involved in immune response (GO:0002281)2.75303416
111negative regulation of T cell mediated immunity (GO:0002710)2.75289351
112positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75016743
113B cell receptor signaling pathway (GO:0050853)2.74409021
114L-phenylalanine catabolic process (GO:0006559)2.74123460
115erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.74123460
116T cell migration (GO:0072678)2.73859157
117positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73408526
118positive regulation of interferon-alpha production (GO:0032727)2.72698876
119primary alcohol catabolic process (GO:0034310)2.72551241
120response to interleukin-15 (GO:0070672)2.72271235
121negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70671686
122regulation of tolerance induction (GO:0002643)2.70619227
123response to peptidoglycan (GO:0032494)2.69627554
124defense response to fungus (GO:0050832)2.69475369
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.69138617
126T cell selection (GO:0045058)2.69055996
127negative regulation of interleukin-6 production (GO:0032715)2.68761419
128positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68609938
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66863240
130macrophage differentiation (GO:0030225)2.66845196
131ethanol oxidation (GO:0006069)2.66805509
132negative regulation of sterol transport (GO:0032372)2.65632949
133negative regulation of cholesterol transport (GO:0032375)2.65632949
134glucose catabolic process (GO:0006007)2.65266305
135response to fungus (GO:0009620)2.64730334
136reverse cholesterol transport (GO:0043691)2.61465921
137complement activation, alternative pathway (GO:0006957)2.61310463
138sterol catabolic process (GO:0016127)2.61149415
139cholesterol catabolic process (GO:0006707)2.61149415
140phospholipid efflux (GO:0033700)2.60982504
141response to interferon-beta (GO:0035456)2.59102273
142protein-lipid complex remodeling (GO:0034368)2.57835282
143macromolecular complex remodeling (GO:0034367)2.57835282
144plasma lipoprotein particle remodeling (GO:0034369)2.57835282
145regulation of lipoprotein particle clearance (GO:0010984)2.57308300
146aromatic amino acid family catabolic process (GO:0009074)2.55834373
147regulation of antigen processing and presentation (GO:0002577)2.54115444
148chaperone mediated protein folding requiring cofactor (GO:0051085)2.51565335
149necroptotic process (GO:0070266)2.50780434
150regulation of interferon-alpha production (GO:0032647)2.50536613
151cellular response to zinc ion (GO:0071294)2.50110397
152bile acid biosynthetic process (GO:0006699)2.49999233
153tryptophan catabolic process (GO:0006569)2.48952449
154indole-containing compound catabolic process (GO:0042436)2.48952449
155indolalkylamine catabolic process (GO:0046218)2.48952449
156pinocytosis (GO:0006907)2.47268455
157pentose metabolic process (GO:0019321)2.46563909
158regulation of phagocytosis (GO:0050764)2.46177435
159complement activation, classical pathway (GO:0006958)2.44921238
160tryptophan metabolic process (GO:0006568)2.44512104
161defense response to protozoan (GO:0042832)2.43932819
162mature B cell differentiation involved in immune response (GO:0002313)2.42879631
163signal peptide processing (GO:0006465)2.42163866
164kynurenine metabolic process (GO:0070189)2.41197792
165negative regulation of erythrocyte differentiation (GO:0045647)2.39582262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.89687897
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.80269771
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.18139178
4* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.95416909
5* VDR_21846776_ChIP-Seq_THP-1_Human2.82477861
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72661263
7MYC_22102868_ChIP-Seq_BL_Human2.65796025
8SCL_19346495_ChIP-Seq_HPC-7_Human2.64818873
9* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.64613157
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.59530113
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55321118
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.53410167
13E2F7_22180533_ChIP-Seq_HELA_Human2.47755784
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41702917
15* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41294726
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40723170
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40195039
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28157824
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24068502
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23525106
21* IRF8_27001747_Chip-Seq_BMDM_Mouse2.20948866
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16982463
23GATA1_22025678_ChIP-Seq_K562_Human2.15603135
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15165900
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.14235390
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.04818734
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04498275
28* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96084279
29* SPI1_23547873_ChIP-Seq_NB4_Human1.92945788
30* VDR_24763502_ChIP-Seq_THP-1_Human1.92099278
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89127229
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87970319
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85101516
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.82341011
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80919226
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.80615820
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80472894
38* LXR_22292898_ChIP-Seq_THP-1_Human1.76216893
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76035814
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75195782
41* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.75083908
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66918113
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66277262
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66256287
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65766460
46LXR_22158963_ChIP-Seq_LIVER_Mouse1.65592741
47MAF_26560356_Chip-Seq_TH1_Human1.63682210
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61666818
49KDM2B_26808549_Chip-Seq_DND41_Human1.57326091
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.55983704
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55464474
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55292565
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52914079
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52681147
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52010427
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48795564
57* SPI1_23127762_ChIP-Seq_K562_Human1.48272893
58TCF7_22412390_ChIP-Seq_EML_Mouse1.44065811
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43492012
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40115840
61UTX_26944678_Chip-Seq_JUKART_Human1.39244799
62MYB_26560356_Chip-Seq_TH2_Human1.39159305
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38775722
64MYB_26560356_Chip-Seq_TH1_Human1.33278225
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31018825
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.28243812
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26309315
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26104476
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.25551823
70CIITA_25753668_ChIP-Seq_RAJI_Human1.25213948
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23352717
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.23062857
73RUNX_20019798_ChIP-Seq_JUKART_Human1.21295640
74* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21235267
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20267174
76GATA3_27048872_Chip-Seq_THYMUS_Human1.20213355
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17974298
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15881719
79* NCOR1_26117541_ChIP-Seq_K562_Human1.12261107
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10627446
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10120003
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.09988999
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09755691
84MAF_26560356_Chip-Seq_TH2_Human1.09455716
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09445195
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09399377
87BCL6_27268052_Chip-Seq_Bcells_Human1.08290132
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.08260491
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07350425
90P68_20966046_ChIP-Seq_HELA_Human1.06828605
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06725423
92* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05999722
93VDR_24787735_ChIP-Seq_THP-1_Human1.05997538
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05448418
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05265528
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05258773
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04621180
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04298632
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.04144825
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03013020
101* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01295008
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.99872050
103RACK7_27058665_Chip-Seq_MCF-7_Human0.98591021
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97594534
105CTCF_26484167_Chip-Seq_Bcells_Mouse0.97059908
106IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95669273
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95249821
108TFEB_21752829_ChIP-Seq_HELA_Human0.95151998
109PU_27001747_Chip-Seq_BMDM_Mouse0.94710902
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94551112
111XRN2_22483619_ChIP-Seq_HELA_Human0.94075661
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93933594
113BCOR_27268052_Chip-Seq_Bcells_Human0.92705084
114E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92307948
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92297056
116SPI1_20517297_ChIP-Seq_HL60_Human0.91941759
117FOXP3_21729870_ChIP-Seq_TREG_Human0.91842318
118FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91752415
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91259451
120* TET1_21451524_ChIP-Seq_MESCs_Mouse0.90426975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.48751191
2MP0005058_abnormal_lysosome_morphology3.29551956
3MP0003191_abnormal_cellular_cholesterol3.10130140
4MP0009840_abnormal_foam_cell2.99730499
5MP0003172_abnormal_lysosome_physiology2.89544356
6MP0002396_abnormal_hematopoietic_system2.80279638
7MP0005365_abnormal_bile_salt2.70849358
8MP0000685_abnormal_immune_system2.54409591
9MP0003436_decreased_susceptibility_to2.51427169
10MP0002139_abnormal_hepatobiliary_system2.49184584
11MP0005464_abnormal_platelet_physiology2.44392162
12MP0005360_urolithiasis2.31038946
13* MP0002419_abnormal_innate_immunity2.28042380
14MP0003303_peritoneal_inflammation2.19224421
15MP0008260_abnormal_autophagy2.17912887
16MP0001790_abnormal_immune_system2.15382315
17MP0005387_immune_system_phenotype2.15382315
18MP0006082_CNS_inflammation2.07964645
19MP0001800_abnormal_humoral_immune2.07681848
20MP0005085_abnormal_gallbladder_physiolo2.07208986
21MP0005025_abnormal_response_to2.05423760
22MP0001873_stomach_inflammation2.04759679
23MP0009785_altered_susceptibility_to2.03950788
24* MP0002452_abnormal_antigen_presenting2.00056356
25MP0005671_abnormal_response_to1.97351025
26MP0005000_abnormal_immune_tolerance1.88558705
27* MP0002723_abnormal_immune_serum1.84815531
28MP0003183_abnormal_peptide_metabolism1.82333317
29MP0002148_abnormal_hypersensitivity_rea1.79684433
30* MP0002420_abnormal_adaptive_immunity1.78908215
31* MP0001819_abnormal_immune_cell1.77844144
32MP0003300_gastrointestinal_ulcer1.73130348
33MP0005083_abnormal_biliary_tract1.71258362
34MP0004510_myositis1.70173810
35MP0008875_abnormal_xenobiotic_pharmacok1.69598450
36MP0002254_reproductive_system_inflammat1.68705418
37MP0003075_altered_response_to1.62583846
38MP0001845_abnormal_inflammatory_respons1.62184458
39MP0003252_abnormal_bile_duct1.58598344
40MP0008469_abnormal_protein_level1.58566553
41MP0001853_heart_inflammation1.58190333
42MP0000689_abnormal_spleen_morphology1.55930618
43MP0010329_abnormal_lipoprotein_level1.55556006
44MP0002398_abnormal_bone_marrow1.54511712
45MP0000716_abnormal_immune_system1.53550045
46MP0005451_abnormal_body_composition1.52670650
47MP0001533_abnormal_skeleton_physiology1.49264688
48MP0000465_gastrointestinal_hemorrhage1.44992551
49MP0002405_respiratory_system_inflammati1.44666040
50MP0000703_abnormal_thymus_morphology1.40837472
51MP0003724_increased_susceptibility_to1.39804374
52MP0002166_altered_tumor_susceptibility1.39578871
53MP0002429_abnormal_blood_cell1.39478227
54MP0005397_hematopoietic_system_phenotyp1.38294371
55MP0001545_abnormal_hematopoietic_system1.38294371
56MP0002722_abnormal_immune_system1.36096957
57MP0009764_decreased_sensitivity_to1.34779649
58MP0005220_abnormal_exocrine_pancreas1.32353836
59MP0003828_pulmonary_edema1.30316643
60MP0000609_abnormal_liver_physiology1.29381839
61MP0009278_abnormal_bone_marrow1.26750837
62MP0009333_abnormal_splenocyte_physiolog1.25846984
63MP0004808_abnormal_hematopoietic_stem1.25157978
64MP0005319_abnormal_enzyme/_coenzyme1.23408403
65MP0001666_abnormal_nutrient_absorption1.19444257
66MP0003186_abnormal_redox_activity1.18761805
67MP0003763_abnormal_thymus_physiology1.17764114
68MP0010155_abnormal_intestine_physiology1.16326027
69MP0003656_abnormal_erythrocyte_physiolo1.16157673
70MP0002933_joint_inflammation1.14364904
71MP0005174_abnormal_tail_pigmentation1.12804312
72MP0005584_abnormal_enzyme/coenzyme_acti1.10972075
73MP0005332_abnormal_amino_acid1.10227852
74MP0002138_abnormal_hepatobiliary_system1.08922146
75MP0004947_skin_inflammation1.08853114
76MP0005310_abnormal_salivary_gland1.07971885
77MP0009643_abnormal_urine_homeostasis1.05067283
78MP0000598_abnormal_liver_morphology1.04319771
79MP0003806_abnormal_nucleotide_metabolis1.04304513
80MP0002118_abnormal_lipid_homeostasis1.03757294
81MP0004883_abnormal_blood_vessel0.99611741
82MP0000490_abnormal_crypts_of0.97903396
83MP0009763_increased_sensitivity_to0.97712698
84MP0004381_abnormal_hair_follicle0.97008167
85MP0001764_abnormal_homeostasis0.95980928
86MP0000604_amyloidosis0.90965178
87MP0005390_skeleton_phenotype0.90781190
88MP0000858_altered_metastatic_potential0.89889937
89MP0003448_altered_tumor_morphology0.89474713
90MP0005166_decreased_susceptibility_to0.88223764
91MP0003638_abnormal_response/metabolism_0.87336400
92MP0000343_altered_response_to0.87248688
93MP0001663_abnormal_digestive_system0.87235461
94MP0002006_tumorigenesis0.87212417
95MP0005075_abnormal_melanosome_morpholog0.86094748
96MP0005670_abnormal_white_adipose0.86040632
97MP0004019_abnormal_vitamin_homeostasis0.85075799
98MP0002132_abnormal_respiratory_system0.84840575
99MP0001851_eye_inflammation0.84781875
100MP0002998_abnormal_bone_remodeling0.83770949
101MP0008438_abnormal_cutaneous_collagen0.82994720
102MP0003283_abnormal_digestive_organ0.82537074
103MP0002928_abnormal_bile_duct0.82187757
104MP0002019_abnormal_tumor_incidence0.82007149
105MP0008007_abnormal_cellular_replicative0.81727234
106MP0003866_abnormal_defecation0.81610646
107MP0005164_abnormal_response_to0.81397503
108MP0008004_abnormal_stomach_pH0.78563715
109MP0009642_abnormal_blood_homeostasis0.77193955
110MP0003690_abnormal_glial_cell0.77112986
111MP0006054_spinal_hemorrhage0.76935813
112MP0000371_diluted_coat_color0.74805218
113MP0000015_abnormal_ear_pigmentation0.69941712
114MP0002277_abnormal_respiratory_mucosa0.69480744
115MP0003795_abnormal_bone_structure0.68348891
116MP0000249_abnormal_blood_vessel0.63483758
117MP0005165_increased_susceptibility_to0.61052063
118MP0009765_abnormal_xenobiotic_induced0.60252057
119MP0008874_decreased_physiological_sensi0.57568489
120MP0000313_abnormal_cell_death0.52679305
121MP0006036_abnormal_mitochondrial_physio0.49704608
122MP0005381_digestive/alimentary_phenotyp0.49034748
123MP0003453_abnormal_keratinocyte_physiol0.48419637
124MP0008873_increased_physiological_sensi0.47531049
125MP0005084_abnormal_gallbladder_morpholo0.47520271
126MP0002877_abnormal_melanocyte_morpholog0.47243582

Predicted human phenotypes

RankGene SetZ-score
1Dysostosis multiplex (HP:0000943)4.43515270
2Chronic obstructive pulmonary disease (HP:0006510)4.40133997
3Stomatitis (HP:0010280)4.19148353
4Mucopolysacchariduria (HP:0008155)4.12996337
5Urinary glycosaminoglycan excretion (HP:0003541)4.12996337
6Abnormality of glycosaminoglycan metabolism (HP:0004371)3.95351918
7Abnormality of mucopolysaccharide metabolism (HP:0011020)3.95351918
8Abnormality of polysaccharide metabolism (HP:0011012)3.95351918
9Orchitis (HP:0100796)3.94322838
10Recurrent abscess formation (HP:0002722)3.90848528
11Systemic lupus erythematosus (HP:0002725)3.82099644
12Recurrent bacterial skin infections (HP:0005406)3.75768218
13Vacuolated lymphocytes (HP:0001922)3.74186122
14Thrombocytosis (HP:0001894)3.58682109
15Agammaglobulinemia (HP:0004432)3.54822021
16Elevated erythrocyte sedimentation rate (HP:0003565)3.51745081
17Retrobulbar optic neuritis (HP:0100654)3.50248044
18Optic neuritis (HP:0100653)3.50248044
19Eczematoid dermatitis (HP:0000976)3.47197158
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.42812816
21Increased IgE level (HP:0003212)3.35839332
22Recurrent gram-negative bacterial infections (HP:0005420)3.35247899
23Increased cerebral lipofuscin (HP:0011813)3.23398618
24Urticaria (HP:0001025)3.21431361
25Encephalitis (HP:0002383)3.19441023
26Chronic otitis media (HP:0000389)3.07619783
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.00105238
28Glomerulonephritis (HP:0000099)2.98867051
29Gastrointestinal infarctions (HP:0005244)2.95778058
30Complement deficiency (HP:0004431)2.90358169
31Chest pain (HP:0100749)2.88954403
32Hepatosplenomegaly (HP:0001433)2.84701867
33Recurrent skin infections (HP:0001581)2.84019006
34IgM deficiency (HP:0002850)2.81031215
35Abnormality of complement system (HP:0005339)2.79194964
36Reduced antithrombin III activity (HP:0001976)2.75967747
37Myositis (HP:0100614)2.75539392
38Osteomyelitis (HP:0002754)2.74395933
39Deep venous thrombosis (HP:0002625)2.69845467
40Pulmonary infiltrates (HP:0002113)2.69045047
41Interstitial pulmonary disease (HP:0006530)2.68209614
42Abnormality of macrophages (HP:0004311)2.67966463
43Granulocytopenia (HP:0001913)2.67484820
44Increased IgM level (HP:0003496)2.65747842
45Joint hemorrhage (HP:0005261)2.65554429
46Abnormality of liposaccharide metabolism (HP:0010968)2.58712961
47Abnormality of glycosphingolipid metabolism (HP:0004343)2.58712961
48Abnormality of glycolipid metabolism (HP:0010969)2.58712961
49Impaired platelet aggregation (HP:0003540)2.58124185
50Abnormal platelet function (HP:0011869)2.58124185
51Increased serum ferritin (HP:0003281)2.56936528
52Thoracic kyphosis (HP:0002942)2.54277037
53Episodic fever (HP:0001954)2.51421088
54Sepsis (HP:0100806)2.50932751
55Recurrent fungal infections (HP:0002841)2.50857316
56Petechiae (HP:0000967)2.47945894
57Vertebral compression fractures (HP:0002953)2.47027191
58Hemoptysis (HP:0002105)2.45700632
59Epistaxis (HP:0000421)2.44331674
60Leukocytosis (HP:0001974)2.44276267
61Hypergammaglobulinemia (HP:0010702)2.44101306
62Prolonged partial thromboplastin time (HP:0003645)2.42508453
63Progressive neurologic deterioration (HP:0002344)2.41669823
64Keratoconjunctivitis sicca (HP:0001097)2.41656519
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40417340
66Gingival bleeding (HP:0000225)2.40223329
67Prolonged bleeding time (HP:0003010)2.40103659
68Gastrointestinal inflammation (HP:0004386)2.38256251
69Colitis (HP:0002583)2.37685215
70Abnormality of the intrinsic pathway (HP:0010989)2.37245113
71Lymphopenia (HP:0001888)2.36610865
72Periodontitis (HP:0000704)2.35651061
73Xanthomatosis (HP:0000991)2.35111833
74Intrahepatic cholestasis (HP:0001406)2.34198248
75Abnormality of T cells (HP:0002843)2.32647178
76Autoimmune thrombocytopenia (HP:0001973)2.32074834
77Loss of speech (HP:0002371)2.31746690
78Late onset (HP:0003584)2.31241434
79Cellulitis (HP:0100658)2.30564532
80Joint stiffness (HP:0001387)2.30123262
81Arterial thrombosis (HP:0004420)2.29828583
82Recurrent viral infections (HP:0004429)2.29695913
83Abnormality of the common coagulation pathway (HP:0010990)2.29084193
84Inflammation of the large intestine (HP:0002037)2.27734553
85Recurrent pneumonia (HP:0006532)2.27298183
86Skin rash (HP:0000988)2.24092914
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.24009046
88Abnormality of iron homeostasis (HP:0011031)2.23858120
89Pulmonary embolism (HP:0002204)2.23100073
90Abnormality of the thoracic spine (HP:0100711)2.23012073
91T lymphocytopenia (HP:0005403)2.21157484
92Abnormality of the prostate (HP:0008775)2.20665706
93Hypochromic anemia (HP:0001931)2.20566755
94Abnormality of cells of the lymphoid lineage (HP:0012140)2.19478795
95Mediastinal lymphadenopathy (HP:0100721)2.19340931
96Hypertensive crisis (HP:0100735)2.19093402
97Large eyes (HP:0001090)2.18218158
98Recurrent lower respiratory tract infections (HP:0002783)2.16957048
99Keratoconjunctivitis (HP:0001096)2.16245369
100Purpura (HP:0000979)2.15294760
101Skin ulcer (HP:0200042)2.13909532
102Chronic mucocutaneous candidiasis (HP:0002728)2.13522014
103Recurrent cutaneous fungal infections (HP:0011370)2.13522014
104Abnormality of T cell physiology (HP:0011840)2.13473558
105Hypochromic microcytic anemia (HP:0004840)2.12008098
106Type I transferrin isoform profile (HP:0003642)2.10750797
107Meningitis (HP:0001287)2.10038962
108Abnormality of the pleura (HP:0002103)2.09700656
109Beaking of vertebral bodies (HP:0004568)2.08737711
110Hypoglycemic coma (HP:0001325)2.08696239
111Anorexia (HP:0002039)2.07704332
112Abnormality of T cell number (HP:0011839)2.06903164
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06779911
114Abnormal protein N-linked glycosylation (HP:0012347)2.06779911
115Abnormal protein glycosylation (HP:0012346)2.06779911
116Abnormal glycosylation (HP:0012345)2.06779911
117Recurrent bronchitis (HP:0002837)2.00342642
118Autoimmune hemolytic anemia (HP:0001890)1.99770166
119Eosinophilia (HP:0001880)1.99572161
120Papilloma (HP:0012740)1.99551215
121Verrucae (HP:0200043)1.99551215
122Vasculitis (HP:0002633)1.98160788
123Glomerulopathy (HP:0100820)1.97501651
124Pathologic fracture (HP:0002756)1.97427330
125Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96903258
126Gangrene (HP:0100758)1.96333478
127Tetraparesis (HP:0002273)1.96092225
128Abnormality of the lumbar spine (HP:0100712)1.95987028
129Abnormality of B cell number (HP:0010975)1.94673087
130Gastrointestinal stroma tumor (HP:0100723)1.94246496
131Ketosis (HP:0001946)1.93096006
132Mitral stenosis (HP:0001718)1.92981729
133Axonal loss (HP:0003447)1.92646675
134Spontaneous hematomas (HP:0007420)1.92074433
135Panhypogammaglobulinemia (HP:0003139)1.90258525
136Amyloidosis (HP:0011034)1.90080471
137Cardiomegaly (HP:0001640)1.89937717
138Menorrhagia (HP:0000132)1.89182327
139Abnormality of the nasal mucosa (HP:0000433)1.86550767
140Nephritis (HP:0000123)1.86443637
141Pustule (HP:0200039)1.85315577
142Generalized aminoaciduria (HP:0002909)1.84186830
143Poikiloderma (HP:0001029)1.82143608
144Gingivitis (HP:0000230)1.82121843
145Albinism (HP:0001022)1.81994305
146Polygenic inheritance (HP:0010982)1.81431090
147Emphysema (HP:0002097)1.79860013
148Myocardial infarction (HP:0001658)1.78016722
149Nasal polyposis (HP:0100582)1.77503971
150Obstructive lung disease (HP:0006536)1.77154728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.94408343
2KIT3.67421732
3MAP4K13.47202411
4FLT32.83759470
5TRIB32.64978544
6MAP2K32.64746620
7CSF1R2.63938783
8BCKDK2.33377555
9TGFBR22.30694701
10TYK22.22694123
11SIK12.21461369
12PKN22.18605911
13PRPF4B2.17760518
14TAOK32.17349346
15TBK12.13247555
16BTK2.06583407
17IRAK41.99908154
18EEF2K1.75539812
19BLK1.66152283
20SCYL21.62396400
21SMG11.56294309
22TEC1.56206243
23TAOK11.49240513
24STK161.49231809
25ZAP701.47865376
26SYK1.47112180
27MAP3K31.40305260
28IRAK31.38547985
29JAK11.37962340
30FGR1.36987692
31SIK31.36588945
32MATK1.36208778
33FES1.33969606
34CAMKK21.28777189
35VRK21.26581290
36MAP3K131.26169428
37JAK31.23209564
38KDR1.20522989
39RPS6KA41.20380800
40CSK1.18914501
41LYN1.13549978
42SIK21.12823566
43PIM21.11341429
44FGFR41.09216886
45GRK61.09099009
46BMPR21.08761963
47ADRBK21.08518071
48MAP3K101.05796064
49TESK21.04261315
50HCK1.02508853
51PAK41.00820860
52EIF2AK31.00126906
53TESK10.98285848
54STK100.95908076
55LRRK20.95661372
56IKBKB0.93685098
57MAP3K110.91493685
58IKBKE0.90972695
59ARAF0.89863332
60ITK0.84043928
61BUB10.82798671
62JAK20.79969110
63CAMKK10.79272864
64EPHB10.76842285
65PTK60.74420100
66MAPK150.73984866
67HIPK20.73944352
68CDK190.73743089
69TAOK20.73730659
70NEK90.71708877
71RIPK40.71389318
72LCK0.69514398
73IRAK20.69113395
74CAMK1D0.67835049
75MAP2K60.67731922
76PDK10.66890163
77CLK10.64587084
78NME20.63367067
79PASK0.62054789
80MARK20.60979956
81TNK20.59978817
82PDPK10.59577448
83YES10.59239578
84PRKD20.54241016
85MAPK120.53928323
86MOS0.52523667
87MAP3K140.51027739
88MAPK110.50320847
89PIK3CG0.49984909
90PRKCH0.49308117
91BMX0.49151668
92DAPK10.48458476
93FYN0.48000772
94PRKCQ0.47520716
95MAPKAPK30.47218289
96GRK70.46950721
97MAP3K50.46047048
98MAPKAPK20.45838480
99KSR20.45307237
100PRKG20.44946144
101PIM10.44802605
102TXK0.43994846
103ABL20.41902682
104PRKCD0.41334827
105TIE10.40821216
106MAP3K80.40795442
107DYRK1B0.40756481
108CDK60.40272068
109MAPK70.40262113
110INSRR0.40200729
111MAPK40.39439587
112RPS6KC10.38458486
113RPS6KL10.38458486
114MARK30.37143575
115CAMK40.37043778
116VRK10.35692350
117MAP3K60.35214387
118CDC42BPA0.34972276
119MAP3K10.34680281
120RAF10.33920675
121EPHA30.33222557
122ATR0.32693047
123MAP3K70.32415192
124IRAK10.32013875
125EGFR0.31705607
126MAPKAPK50.31639573
127PAK10.31056431
128NEK20.31000720
129CHUK0.30522926
130CDK40.29939222
131PAK20.29791984
132TGFBR10.28760182
133CCNB10.28708106
134MAP2K20.26747425
135RPS6KA60.24841969
136PRKD10.23933772

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.33508437
2Allograft rejection_Homo sapiens_hsa053303.12237099
3Other glycan degradation_Homo sapiens_hsa005112.96346187
4Graft-versus-host disease_Homo sapiens_hsa053322.95162452
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.91024744
6Autoimmune thyroid disease_Homo sapiens_hsa053202.87794677
7Staphylococcus aureus infection_Homo sapiens_hsa051502.69720965
8Asthma_Homo sapiens_hsa053102.56992952
9Lysosome_Homo sapiens_hsa041422.33902331
10Sulfur relay system_Homo sapiens_hsa041222.30699564
11Type I diabetes mellitus_Homo sapiens_hsa049402.26188131
12Selenocompound metabolism_Homo sapiens_hsa004502.15990792
13Complement and coagulation cascades_Homo sapiens_hsa046102.05441280
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.01795420
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98681880
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98098016
17Viral myocarditis_Homo sapiens_hsa054161.95780914
18N-Glycan biosynthesis_Homo sapiens_hsa005101.93450156
19Folate biosynthesis_Homo sapiens_hsa007901.91156537
20DNA replication_Homo sapiens_hsa030301.86319121
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84833079
22Nitrogen metabolism_Homo sapiens_hsa009101.80635854
23Protein export_Homo sapiens_hsa030601.71750645
24Leishmaniasis_Homo sapiens_hsa051401.69480814
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66539056
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.64366720
27One carbon pool by folate_Homo sapiens_hsa006701.62063377
28Antigen processing and presentation_Homo sapiens_hsa046121.58776790
29Rheumatoid arthritis_Homo sapiens_hsa053231.55502214
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53094377
31Fatty acid degradation_Homo sapiens_hsa000711.50537389
32B cell receptor signaling pathway_Homo sapiens_hsa046621.50068984
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40603654
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37659207
35Tryptophan metabolism_Homo sapiens_hsa003801.37453026
36Primary immunodeficiency_Homo sapiens_hsa053401.28978506
37T cell receptor signaling pathway_Homo sapiens_hsa046601.27152270
38Chemokine signaling pathway_Homo sapiens_hsa040621.26020199
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25788626
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24088041
41Legionellosis_Homo sapiens_hsa051341.23379327
42Pentose phosphate pathway_Homo sapiens_hsa000301.23199207
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.21312524
44Galactose metabolism_Homo sapiens_hsa000521.21266908
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21124660
46Peroxisome_Homo sapiens_hsa041461.19971772
47Arginine biosynthesis_Homo sapiens_hsa002201.19116415
48Osteoclast differentiation_Homo sapiens_hsa043801.18846109
49ABC transporters_Homo sapiens_hsa020101.18113595
50Salmonella infection_Homo sapiens_hsa051321.16683444
51Caffeine metabolism_Homo sapiens_hsa002321.11899447
52Biosynthesis of amino acids_Homo sapiens_hsa012301.09694299
53Base excision repair_Homo sapiens_hsa034101.09665890
54Platelet activation_Homo sapiens_hsa046111.07792877
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07155612
56Histidine metabolism_Homo sapiens_hsa003401.04550435
57Pertussis_Homo sapiens_hsa051331.03973323
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03970500
59Fructose and mannose metabolism_Homo sapiens_hsa000511.02770906
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02632230
61Epstein-Barr virus infection_Homo sapiens_hsa051691.01858733
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01395954
63Starch and sucrose metabolism_Homo sapiens_hsa005001.01007090
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.00057810
65African trypanosomiasis_Homo sapiens_hsa051430.98437578
66TNF signaling pathway_Homo sapiens_hsa046680.97580909
67Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96066697
68Hematopoietic cell lineage_Homo sapiens_hsa046400.92631732
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.91248631
70beta-Alanine metabolism_Homo sapiens_hsa004100.91220255
71Non-small cell lung cancer_Homo sapiens_hsa052230.90950072
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87718984
73Tuberculosis_Homo sapiens_hsa051520.87028665
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85809222
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.85055144
76Chemical carcinogenesis_Homo sapiens_hsa052040.82793509
77Measles_Homo sapiens_hsa051620.82734271
78Mismatch repair_Homo sapiens_hsa034300.82634416
79Hepatitis C_Homo sapiens_hsa051600.82558018
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81709592
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81596477
82Pancreatic cancer_Homo sapiens_hsa052120.80721026
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79275341
84Fatty acid metabolism_Homo sapiens_hsa012120.77507256
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76806896
86HTLV-I infection_Homo sapiens_hsa051660.73598544
87Chronic myeloid leukemia_Homo sapiens_hsa052200.73229723
88Renin-angiotensin system_Homo sapiens_hsa046140.72845619
89Carbon metabolism_Homo sapiens_hsa012000.69862556
90Malaria_Homo sapiens_hsa051440.68942425
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68146638
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68115899
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67402515
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66934039
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.66895231
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66574293
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66541479
98Endocytosis_Homo sapiens_hsa041440.66522992
99Herpes simplex infection_Homo sapiens_hsa051680.65633931
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65239069
101Ribosome_Homo sapiens_hsa030100.65232004
102VEGF signaling pathway_Homo sapiens_hsa043700.64067671
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63734983
104Viral carcinogenesis_Homo sapiens_hsa052030.63149940
105Acute myeloid leukemia_Homo sapiens_hsa052210.62332870
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62314627
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61653978
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61382973
109Apoptosis_Homo sapiens_hsa042100.60474711
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59986374
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59104051
112Systemic lupus erythematosus_Homo sapiens_hsa053220.57376059
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57024593
114Lysine degradation_Homo sapiens_hsa003100.56942672
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54812083
116Influenza A_Homo sapiens_hsa051640.54366504
117Pyrimidine metabolism_Homo sapiens_hsa002400.53844253
118Shigellosis_Homo sapiens_hsa051310.53802165
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.53677972
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.53390841
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53112409
122Non-homologous end-joining_Homo sapiens_hsa034500.51745282
123Sulfur metabolism_Homo sapiens_hsa009200.51632037
124Phagosome_Homo sapiens_hsa041450.50781930
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50636987
126Notch signaling pathway_Homo sapiens_hsa043300.50262984
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49838019
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.48178181
129PPAR signaling pathway_Homo sapiens_hsa033200.47842557
130Prion diseases_Homo sapiens_hsa050200.45856207
131Toxoplasmosis_Homo sapiens_hsa051450.44763228
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.44360029
133Hepatitis B_Homo sapiens_hsa051610.44096941
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43845031
135Bladder cancer_Homo sapiens_hsa052190.43209792
136Homologous recombination_Homo sapiens_hsa034400.41175753
137Phenylalanine metabolism_Homo sapiens_hsa003600.39563872
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39467221
139Amoebiasis_Homo sapiens_hsa051460.38555342
140HIF-1 signaling pathway_Homo sapiens_hsa040660.32470150
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31646513
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.29500145
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.29068752
144Proteasome_Homo sapiens_hsa030500.29044316
145Collecting duct acid secretion_Homo sapiens_hsa049660.28760475
146Regulation of autophagy_Homo sapiens_hsa041400.28729675
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.25307140
148Colorectal cancer_Homo sapiens_hsa052100.25155429
149Prolactin signaling pathway_Homo sapiens_hsa049170.24087915
150Renal cell carcinoma_Homo sapiens_hsa052110.23750955
151Endometrial cancer_Homo sapiens_hsa052130.18029792

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