CNPY4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.06438863
2sequestering of actin monomers (GO:0042989)4.91353416
3ribosomal small subunit assembly (GO:0000028)4.45960021
4CENP-A containing nucleosome assembly (GO:0034080)4.40212438
5attachment of spindle microtubules to kinetochore (GO:0008608)4.13503780
6chromatin remodeling at centromere (GO:0031055)4.07356074
7kinetochore organization (GO:0051383)3.99808917
8telomere maintenance via semi-conservative replication (GO:0032201)3.99238345
9platelet dense granule organization (GO:0060155)3.95814093
10telomere maintenance via recombination (GO:0000722)3.91764456
11DNA strand elongation involved in DNA replication (GO:0006271)3.87897060
12mitotic metaphase plate congression (GO:0007080)3.77788538
13DNA strand elongation (GO:0022616)3.77760507
14maturation of 5.8S rRNA (GO:0000460)3.74582237
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72809187
16kinetochore assembly (GO:0051382)3.67674019
17DNA replication-independent nucleosome assembly (GO:0006336)3.64573026
18DNA replication-independent nucleosome organization (GO:0034724)3.64573026
19DNA replication checkpoint (GO:0000076)3.62178487
20epithelial cilium movement (GO:0003351)3.62133893
21establishment of chromosome localization (GO:0051303)3.61598167
22DNA replication initiation (GO:0006270)3.61220607
23mitotic recombination (GO:0006312)3.55852295
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.55765561
25NADH dehydrogenase complex assembly (GO:0010257)3.55765561
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55765561
27metaphase plate congression (GO:0051310)3.51061152
28mannosylation (GO:0097502)3.49253404
29negative regulation of telomere maintenance (GO:0032205)3.48111799
30nonmotile primary cilium assembly (GO:0035058)3.41872777
31protein localization to kinetochore (GO:0034501)3.40960862
32regulation of double-strand break repair via homologous recombination (GO:0010569)3.32555036
33negative regulation of axon guidance (GO:1902668)3.30358916
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.28658464
35telomere maintenance via telomere lengthening (GO:0010833)3.26288411
36proteasome assembly (GO:0043248)3.25862013
37protein complex biogenesis (GO:0070271)3.25789833
38meiotic chromosome segregation (GO:0045132)3.24822574
39histone exchange (GO:0043486)3.24241002
40mitotic sister chromatid segregation (GO:0000070)3.21463743
41pyrimidine nucleobase catabolic process (GO:0006208)3.19260773
42positive regulation of gastrulation (GO:2000543)3.18202851
43head development (GO:0060322)3.12745847
44negative regulation of mast cell activation (GO:0033004)3.11227580
45IMP metabolic process (GO:0046040)3.11122257
46protein deneddylation (GO:0000338)3.10448302
47nucleobase biosynthetic process (GO:0046112)3.09401129
48cilium morphogenesis (GO:0060271)3.08110750
49ATP synthesis coupled proton transport (GO:0015986)3.07474027
50energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07474027
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07004024
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07004024
53purine nucleobase biosynthetic process (GO:0009113)3.01724027
54regulation of development, heterochronic (GO:0040034)3.01639089
55protein localization to chromosome, centromeric region (GO:0071459)2.99041461
56IMP biosynthetic process (GO:0006188)2.98600015
57mitochondrial respiratory chain complex assembly (GO:0033108)2.98199596
58smoothened signaling pathway (GO:0007224)2.96661827
59photoreceptor cell development (GO:0042461)2.95966754
60intraciliary transport (GO:0042073)2.95718406
61preassembly of GPI anchor in ER membrane (GO:0016254)2.94898171
62cullin deneddylation (GO:0010388)2.93847894
63regulation of timing of cell differentiation (GO:0048505)2.93695142
64regulation of spindle organization (GO:0090224)2.93055015
65retinal ganglion cell axon guidance (GO:0031290)2.92939841
66sister chromatid segregation (GO:0000819)2.92451795
67cytidine deamination (GO:0009972)2.92157201
68cytidine metabolic process (GO:0046087)2.92157201
69cytidine catabolic process (GO:0006216)2.92157201
70RNA-dependent DNA replication (GO:0006278)2.91715057
71telomere maintenance (GO:0000723)2.91620614
72DNA deamination (GO:0045006)2.90880768
73regulation of cilium movement (GO:0003352)2.89638195
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89603093
75regulation of mitotic spindle checkpoint (GO:1903504)2.89603093
76cilium movement (GO:0003341)2.89597556
77telomere organization (GO:0032200)2.89454530
78cilium organization (GO:0044782)2.89062560
79DNA ligation (GO:0006266)2.88096334
80transcription-coupled nucleotide-excision repair (GO:0006283)2.87443489
81limb bud formation (GO:0060174)2.85704645
82viral mRNA export from host cell nucleus (GO:0046784)2.84407509
83nucleotide transmembrane transport (GO:1901679)2.84150253
84chromosome segregation (GO:0007059)2.83944144
85spindle checkpoint (GO:0031577)2.81224210
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80589547
87negative regulation of axon extension involved in axon guidance (GO:0048843)2.80496299
88cornea development in camera-type eye (GO:0061303)2.80446956
89mitotic chromosome condensation (GO:0007076)2.80434827
90cilium assembly (GO:0042384)2.79417782
91establishment of protein localization to mitochondrial membrane (GO:0090151)2.79335456
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79325495
93iron-sulfur cluster assembly (GO:0016226)2.79295260
94metallo-sulfur cluster assembly (GO:0031163)2.79295260
95definitive hemopoiesis (GO:0060216)2.79211668
96mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78915043
97regulation of action potential (GO:0098900)2.77618755
98RNA capping (GO:0036260)2.77336632
997-methylguanosine RNA capping (GO:0009452)2.77336632
100mitotic G2/M transition checkpoint (GO:0044818)2.77118169
101negative regulation of phagocytosis (GO:0050765)2.76742646
102negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75717369
103negative regulation of oligodendrocyte differentiation (GO:0048715)2.75035504
1047-methylguanosine mRNA capping (GO:0006370)2.74349156
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74175789
106formation of translation preinitiation complex (GO:0001731)2.73793788
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73616513
108somite development (GO:0061053)2.73084395
109maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72924991
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.72616985
111protein heterotrimerization (GO:0070208)2.72000085
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71296477
113mitotic nuclear envelope disassembly (GO:0007077)2.67511050
114axoneme assembly (GO:0035082)2.67280125
115pyrimidine ribonucleoside catabolic process (GO:0046133)2.66695736
116nephron epithelium morphogenesis (GO:0072088)2.66511254
117nephron tubule morphogenesis (GO:0072078)2.66511254
118DNA unwinding involved in DNA replication (GO:0006268)2.66450049
119transcription elongation from RNA polymerase III promoter (GO:0006385)2.66370606
120termination of RNA polymerase III transcription (GO:0006386)2.66370606
121spliceosomal snRNP assembly (GO:0000387)2.66083773
122regulation of neurotransmitter uptake (GO:0051580)2.65561703
123organelle disassembly (GO:1903008)2.64489178
124nucleobase catabolic process (GO:0046113)2.64310279
125regulation of double-strand break repair (GO:2000779)2.63685135
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63082774
127spindle assembly checkpoint (GO:0071173)2.61808867
128chaperone-mediated protein transport (GO:0072321)2.61391935
129replication fork processing (GO:0031297)2.61064021
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61001847
131G1/S transition of mitotic cell cycle (GO:0000082)2.60991095
132cell cycle G1/S phase transition (GO:0044843)2.60991095
133spinal cord development (GO:0021510)2.60420847
134transmission of nerve impulse (GO:0019226)2.60397979
135ATP-dependent chromatin remodeling (GO:0043044)2.60212636
136detection of light stimulus involved in visual perception (GO:0050908)2.59987558
137detection of light stimulus involved in sensory perception (GO:0050962)2.59987558
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59874577
139mismatch repair (GO:0006298)2.59809534
140eye photoreceptor cell development (GO:0042462)2.59303339
141negative regulation of axon extension (GO:0030517)2.59033260
142negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.58617716
143negative regulation of sister chromatid segregation (GO:0033046)2.58617716
144negative regulation of mitotic sister chromatid separation (GO:2000816)2.58617716
145negative regulation of mitotic sister chromatid segregation (GO:0033048)2.58617716
146neural tube formation (GO:0001841)2.58406426
147protein localization to chromosome (GO:0034502)2.58222472
148histone mRNA metabolic process (GO:0008334)2.57752048
149mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57483337
150pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.57258443
151somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56916080
152somatic hypermutation of immunoglobulin genes (GO:0016446)2.56916080
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56488592
154ribosome biogenesis (GO:0042254)2.56412074
155regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56365127
156neuron fate determination (GO:0048664)2.55661601
157regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55318945
158negative regulation of ligase activity (GO:0051352)2.54054307
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54054307
160protein-cofactor linkage (GO:0018065)2.54033616
161mitotic spindle assembly checkpoint (GO:0007094)2.53977592
162DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.53709210
163DNA replication (GO:0006260)2.52708654
164maturation of SSU-rRNA (GO:0030490)2.52704618
165negative regulation of chromosome segregation (GO:0051985)2.52064249
166protein neddylation (GO:0045116)2.51861549
167mitotic G2 DNA damage checkpoint (GO:0007095)2.51468950
168regulation of mitotic spindle organization (GO:0060236)2.51062628
169intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.50397113
170neuron projection extension involved in neuron projection guidance (GO:1902284)2.49535769
171axon extension involved in axon guidance (GO:0048846)2.49535769
172type B pancreatic cell proliferation (GO:0044342)2.49150182
173kidney morphogenesis (GO:0060993)2.47304807
174regulation of interleukin-8 secretion (GO:2000482)2.45678507
175positive regulation of defense response to virus by host (GO:0002230)2.45530285
176protein localization to cilium (GO:0061512)2.45420598
177synaptic transmission, cholinergic (GO:0007271)2.43740252
178regulation of telomere maintenance (GO:0032204)2.43122369
179presynaptic membrane assembly (GO:0097105)2.42484857
180respiratory chain complex IV assembly (GO:0008535)2.42180090
181negative regulation of nitric-oxide synthase activity (GO:0051001)2.41089368
182cellular ketone body metabolic process (GO:0046950)2.40131255
183limb development (GO:0060173)2.40077794
184appendage development (GO:0048736)2.40077794
185detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39418953
186GPI anchor metabolic process (GO:0006505)2.38700275
187regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.37248143
188regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.37248143
189protein K6-linked ubiquitination (GO:0085020)2.36934878
190L-fucose catabolic process (GO:0042355)2.36855317
191fucose catabolic process (GO:0019317)2.36855317
192L-fucose metabolic process (GO:0042354)2.36855317
193peptidyl-histidine modification (GO:0018202)2.36684520
194intracellular protein transmembrane import (GO:0044743)2.35803597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.75181055
2ZNF274_21170338_ChIP-Seq_K562_Hela4.18247012
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97645188
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59696725
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.48129281
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.48034971
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47534329
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.37373176
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.33448036
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.15860551
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.94390787
12VDR_22108803_ChIP-Seq_LS180_Human2.86729221
13EZH2_22144423_ChIP-Seq_EOC_Human2.81592452
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.79171942
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67395589
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66832037
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55962478
18GBX2_23144817_ChIP-Seq_PC3_Human2.55104646
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52979856
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51615072
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45930327
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.45543570
23ELK1_19687146_ChIP-ChIP_HELA_Human2.45130808
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39584495
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37812114
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36670406
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29298366
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28292320
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23200142
30* VDR_23849224_ChIP-Seq_CD4+_Human2.22407262
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16312182
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11923321
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.11742142
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11700055
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.10471934
36MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05145476
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.03620604
38TP63_19390658_ChIP-ChIP_HaCaT_Human2.03344998
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00532239
40AR_21909140_ChIP-Seq_LNCAP_Human2.00272266
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.99478830
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.98357642
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.94657911
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94267583
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91339155
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.87830901
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87013809
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84557499
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.82915004
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82834789
51IGF1R_20145208_ChIP-Seq_DFB_Human1.82498515
52XRN2_22483619_ChIP-Seq_HELA_Human1.81055998
53DCP1A_22483619_ChIP-Seq_HELA_Human1.80124891
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74842074
55* TTF2_22483619_ChIP-Seq_HELA_Human1.74752836
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73109818
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.72577162
58TP53_22573176_ChIP-Seq_HFKS_Human1.72057542
59GABP_19822575_ChIP-Seq_HepG2_Human1.70921175
60P300_19829295_ChIP-Seq_ESCs_Human1.67465514
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64977488
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64371730
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64221452
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63432724
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63121872
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62406263
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58607987
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.58544484
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58500994
70FUS_26573619_Chip-Seq_HEK293_Human1.57452173
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55478737
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55077467
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.54457410
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51588519
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51180027
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50625395
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49573972
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47758371
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46061189
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44754780
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44052348
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43739969
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37467245
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.34422369
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.32830199
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29166767
87ER_23166858_ChIP-Seq_MCF-7_Human1.29127479
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28263559
89TAF15_26573619_Chip-Seq_HEK293_Human1.28232909
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25517669
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24910703
92CIITA_25753668_ChIP-Seq_RAJI_Human1.24852137
93SPI1_23547873_ChIP-Seq_NB4_Human1.24791009
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22067242
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22020705
96* YY1_21170310_ChIP-Seq_MESCs_Mouse1.21940049
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20986985
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20891360
99MYC_18940864_ChIP-ChIP_HL60_Human1.20500501
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19535405
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18781222
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.18627125
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18563620
104SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.18523698
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.17568468
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17568468
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15290215
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15188432
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15171132
110AR_20517297_ChIP-Seq_VCAP_Human1.15109639
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14982187
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.14978354
113RNF2_27304074_Chip-Seq_NSC_Mouse1.13376199
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12972585
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12643910
116KDM5A_27292631_Chip-Seq_BREAST_Human1.12385710
117ERA_21632823_ChIP-Seq_H3396_Human1.12330624
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11348729
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11014613
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10746267
121BCAT_22108803_ChIP-Seq_LS180_Human1.10647477
122SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10327284
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10044991
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.08278552
125ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08100148
126ELK1_22589737_ChIP-Seq_MCF10A_Human1.07939702
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.07670269
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06733487
129NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06298862
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05827278
131MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05702362
132SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04963962
133RUNX2_22187159_ChIP-Seq_PCA_Human1.03551499
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02486561
135AR_25329375_ChIP-Seq_VCAP_Human1.02480771
136CBP_20019798_ChIP-Seq_JUKART_Human1.01882960
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01882960
138MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01801633
139SMAD3_21741376_ChIP-Seq_EPCs_Human1.01489560
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00548845
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.99955770
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.99850399
143SOX2_19829295_ChIP-Seq_ESCs_Human0.97711281
144NANOG_19829295_ChIP-Seq_ESCs_Human0.97711281
145JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96774321
146BP1_19119308_ChIP-ChIP_Hs578T_Human0.95743567
147SMAD4_21799915_ChIP-Seq_A2780_Human0.95570564
148REST_21632747_ChIP-Seq_MESCs_Mouse0.94966542
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94692616
150RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93100841
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92336211
152CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91580297
153SOX2_16153702_ChIP-ChIP_HESCs_Human0.91130495
154CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91128465
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91094462
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.90584545
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90359679
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90359679
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90355921
160SOX17_20123909_ChIP-Seq_XEN_Mouse0.90316446
161IRF1_19129219_ChIP-ChIP_H3396_Human0.90301721
162OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90200040
163SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89220404
164EWS_26573619_Chip-Seq_HEK293_Human0.88474176
165CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87582896
166TFEB_21752829_ChIP-Seq_HELA_Human0.86696633
167E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.86324120
168NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83999158
169BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83777598
170STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82032532
171NANOG_16153702_ChIP-ChIP_HESCs_Human0.81144613
172PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80096212
173POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79732174
174GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79575184
175HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75228687
176KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74291862
177SCL_19346495_ChIP-Seq_HPC-7_Human0.73354140
178TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72808308
179FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71960279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.62193625
2MP0008007_abnormal_cellular_replicative3.30047096
3MP0002102_abnormal_ear_morphology3.25595271
4MP0003011_delayed_dark_adaptation3.10495275
5MP0003693_abnormal_embryo_hatching3.01904994
6MP0006054_spinal_hemorrhage2.90018150
7MP0003077_abnormal_cell_cycle2.88202951
8MP0002396_abnormal_hematopoietic_system2.87811997
9MP0008058_abnormal_DNA_repair2.69779949
10MP0002653_abnormal_ependyma_morphology2.66296819
11MP0003111_abnormal_nucleus_morphology2.65828262
12MP0008438_abnormal_cutaneous_collagen2.63921104
13MP0004957_abnormal_blastocyst_morpholog2.62167008
14MP0000569_abnormal_digit_pigmentation2.51529783
15MP0006292_abnormal_olfactory_placode2.42256158
16MP0003283_abnormal_digestive_organ2.38197817
17MP0005503_abnormal_tendon_morphology2.36576151
18MP0008057_abnormal_DNA_replication2.32917951
19MP0005171_absent_coat_pigmentation2.27458303
20MP0003279_aneurysm2.25861629
21MP0002638_abnormal_pupillary_reflex2.24043124
22MP0006072_abnormal_retinal_apoptosis2.23853491
23MP0005551_abnormal_eye_electrophysiolog2.21262508
24MP0003123_paternal_imprinting2.20128342
25MP0009697_abnormal_copulation2.19264156
26MP0001986_abnormal_taste_sensitivity2.18285740
27MP0008932_abnormal_embryonic_tissue2.06382803
28MP0010386_abnormal_urinary_bladder2.03960566
29MP0003121_genomic_imprinting2.03169437
30MP0003136_yellow_coat_color1.97140469
31MP0004133_heterotaxia1.92790969
32MP0004808_abnormal_hematopoietic_stem1.87210821
33MP0005253_abnormal_eye_physiology1.83107494
34MP0008877_abnormal_DNA_methylation1.77202165
35MP0003718_maternal_effect1.75804168
36MP0003786_premature_aging1.72645981
37MP0005084_abnormal_gallbladder_morpholo1.63596637
38MP0000372_irregular_coat_pigmentation1.59154131
39MP0002736_abnormal_nociception_after1.58882845
40MP0002751_abnormal_autonomic_nervous1.52920601
41MP0004142_abnormal_muscle_tone1.51524765
42MP0000778_abnormal_nervous_system1.50790225
43MP0003763_abnormal_thymus_physiology1.46572070
44MP0002928_abnormal_bile_duct1.45292522
45MP0005408_hypopigmentation1.44027502
46MP0002822_catalepsy1.38841645
47MP0000490_abnormal_crypts_of1.37790871
48MP0001968_abnormal_touch/_nociception1.37259809
49MP0001529_abnormal_vocalization1.35774217
50MP0008789_abnormal_olfactory_epithelium1.32225055
51MP0010030_abnormal_orbit_morphology1.30747096
52MP0000350_abnormal_cell_proliferation1.30587327
53MP0001119_abnormal_female_reproductive1.28852942
54MP0009250_abnormal_appendicular_skeleto1.28424918
55MP0005174_abnormal_tail_pigmentation1.28352279
56MP0005394_taste/olfaction_phenotype1.24880576
57MP0005499_abnormal_olfactory_system1.24880576
58MP0003119_abnormal_digestive_system1.24590531
59MP0010368_abnormal_lymphatic_system1.23135857
60MP0006276_abnormal_autonomic_nervous1.22306755
61MP0001905_abnormal_dopamine_level1.19788049
62MP0003943_abnormal_hepatobiliary_system1.18918310
63MP0005195_abnormal_posterior_eye1.17943689
64MP0005275_abnormal_skin_tensile1.17599299
65MP0001879_abnormal_lymphatic_vessel1.17053006
66MP0002938_white_spotting1.16626007
67MP0002295_abnormal_pulmonary_circulatio1.16122252
68MP0000427_abnormal_hair_cycle1.15550854
69MP0000631_abnormal_neuroendocrine_gland1.14588869
70MP0005391_vision/eye_phenotype1.14155858
71MP0000465_gastrointestinal_hemorrhage1.13108110
72MP0003787_abnormal_imprinting1.12328437
73MP0002282_abnormal_trachea_morphology1.11647870
74MP0005397_hematopoietic_system_phenotyp1.11136030
75MP0001545_abnormal_hematopoietic_system1.11136030
76MP0004885_abnormal_endolymph1.09793489
77MP0000026_abnormal_inner_ear1.09729715
78MP0000538_abnormal_urinary_bladder1.09678671
79MP0009333_abnormal_splenocyte_physiolog1.09468036
80MP0000566_synostosis1.09388679
81MP0002019_abnormal_tumor_incidence1.08916296
82MP0003878_abnormal_ear_physiology1.08619605
83MP0005377_hearing/vestibular/ear_phenot1.08619605
84MP0002009_preneoplasia1.07425503
85MP0003315_abnormal_perineum_morphology1.07362739
86MP0000015_abnormal_ear_pigmentation1.07142376
87MP0000858_altered_metastatic_potential1.06924096
88MP0005508_abnormal_skeleton_morphology1.06268053
89MP0001730_embryonic_growth_arrest1.04916299
90MP0001958_emphysema1.03550280
91MP0002876_abnormal_thyroid_physiology1.03094292
92MP0001324_abnormal_eye_pigmentation1.02766022
93MP0010307_abnormal_tumor_latency1.02519912
94MP0005595_abnormal_vascular_smooth1.01883958
95MP0002160_abnormal_reproductive_system1.01107529
96MP0002398_abnormal_bone_marrow1.00341633
97MP0009745_abnormal_behavioral_response1.00282789
98MP0002752_abnormal_somatic_nervous0.98084563
99MP0001919_abnormal_reproductive_system0.97857756
100MP0001697_abnormal_embryo_size0.97753369
101MP0005389_reproductive_system_phenotype0.97208772
102MP0005023_abnormal_wound_healing0.97195681
103MP0001243_abnormal_dermal_layer0.97073002
104MP0002557_abnormal_social/conspecific_i0.97027977
105MP0005645_abnormal_hypothalamus_physiol0.96901936
106MP0005075_abnormal_melanosome_morpholog0.96492514
107MP0001542_abnormal_bone_strength0.96150927
108MP0000767_abnormal_smooth_muscle0.95756425
109MP0000313_abnormal_cell_death0.95606769
110MP0003880_abnormal_central_pattern0.95317067
111MP0002095_abnormal_skin_pigmentation0.95282569
112MP0003942_abnormal_urinary_system0.95126219
113MP0003385_abnormal_body_wall0.94864003
114MP0002166_altered_tumor_susceptibility0.94520057
115MP0003724_increased_susceptibility_to0.94184267
116MP0001915_intracranial_hemorrhage0.93956384
117MP0003941_abnormal_skin_development0.93895583
118MP0000516_abnormal_urinary_system0.93173179
119MP0005367_renal/urinary_system_phenotyp0.93173179
120MP0008872_abnormal_physiological_respon0.92824758
121MP0002572_abnormal_emotion/affect_behav0.90300118
122MP0001835_abnormal_antigen_presentation0.90299621
123MP0003137_abnormal_impulse_conducting0.90274842
124MP0009379_abnormal_foot_pigmentation0.89991140
125MP0001672_abnormal_embryogenesis/_devel0.89970980
126MP0005380_embryogenesis_phenotype0.89970980
127MP0001188_hyperpigmentation0.89407551
128MP0000689_abnormal_spleen_morphology0.89019367
129MP0002249_abnormal_larynx_morphology0.88666328
130MP0001293_anophthalmia0.88211546
131MP0004134_abnormal_chest_morphology0.87911916
132MP0004272_abnormal_basement_membrane0.86928251
133MP0003937_abnormal_limbs/digits/tail_de0.86670651
134MP0002735_abnormal_chemical_nociception0.86576195
135MP0005623_abnormal_meninges_morphology0.85429495
136MP0001502_abnormal_circadian_rhythm0.85425327
137MP0003938_abnormal_ear_development0.84441765
138MP0002210_abnormal_sex_determination0.84315596
139MP0002006_tumorigenesis0.82885641
140MP0005671_abnormal_response_to0.81961381
141MP0002722_abnormal_immune_system0.81283716
142MP0002932_abnormal_joint_morphology0.81005483
143MP0001299_abnormal_eye_distance/0.80738622
144MP0005390_skeleton_phenotype0.80496849
145MP0003122_maternal_imprinting0.80284319
146MP0003984_embryonic_growth_retardation0.79858279
147MP0009046_muscle_twitch0.79135707
148MP0002080_prenatal_lethality0.78875264
149MP0009053_abnormal_anal_canal0.78770415
150MP0002233_abnormal_nose_morphology0.78718213
151MP0003567_abnormal_fetal_cardiomyocyte0.78665901
152MP0000703_abnormal_thymus_morphology0.77713728
153MP0000013_abnormal_adipose_tissue0.77682211
154MP0001984_abnormal_olfaction0.77303526
155MP0002108_abnormal_muscle_morphology0.77300655
156MP0002088_abnormal_embryonic_growth/wei0.76948110
157MP0005423_abnormal_somatic_nervous0.76811137
158MP0002429_abnormal_blood_cell0.76790379
159MP0002109_abnormal_limb_morphology0.76679866
160MP0002085_abnormal_embryonic_tissue0.76036051
161MP0002933_joint_inflammation0.75609610
162MP0000049_abnormal_middle_ear0.75457746
163MP0003755_abnormal_palate_morphology0.75280073
164MP0004147_increased_porphyrin_level0.74836837
165MP0002060_abnormal_skin_morphology0.74665335
166MP0000343_altered_response_to0.74605947
167MP0009384_cardiac_valve_regurgitation0.74561312

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.67744310
2Pancreatic cysts (HP:0001737)4.39356767
3Molar tooth sign on MRI (HP:0002419)4.25691240
4Abnormality of midbrain morphology (HP:0002418)4.25691240
5Cerebellar dysplasia (HP:0007033)3.75309215
6Retinal dysplasia (HP:0007973)3.73577337
7Chromsome breakage (HP:0040012)3.63948155
8Birth length less than 3rd percentile (HP:0003561)3.62661686
9Congenital stationary night blindness (HP:0007642)3.59155045
10Nephronophthisis (HP:0000090)3.44676885
11Medial flaring of the eyebrow (HP:0010747)3.43871405
12Aplastic anemia (HP:0001915)3.19579748
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.17528069
14Abnormal lung lobation (HP:0002101)3.10197155
15Increased corneal curvature (HP:0100692)3.09526730
16Keratoconus (HP:0000563)3.09526730
17Breast hypoplasia (HP:0003187)2.98550153
18Thrombocytosis (HP:0001894)2.95345456
19Sclerocornea (HP:0000647)2.84046499
20Occipital encephalocele (HP:0002085)2.79813118
2111 pairs of ribs (HP:0000878)2.79106160
22Protrusio acetabuli (HP:0003179)2.77613367
23Meckel diverticulum (HP:0002245)2.75280874
24Degeneration of anterior horn cells (HP:0002398)2.74691868
25Abnormality of the anterior horn cell (HP:0006802)2.74691868
26Gait imbalance (HP:0002141)2.73557807
27Lissencephaly (HP:0001339)2.73526711
28Congenital primary aphakia (HP:0007707)2.68643851
29Abnormality of chromosome stability (HP:0003220)2.65758128
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62549281
31Cystic liver disease (HP:0006706)2.62463519
32Patellar aplasia (HP:0006443)2.60276924
33Abnormality of the ileum (HP:0001549)2.59193940
34Anencephaly (HP:0002323)2.58299467
35Abnormality of the preputium (HP:0100587)2.58114990
36Anterior segment dysgenesis (HP:0007700)2.57071274
37Abnormality of the renal medulla (HP:0100957)2.55940160
38Type I transferrin isoform profile (HP:0003642)2.55379698
39Rib fusion (HP:0000902)2.54140042
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.53400954
41Short 4th metacarpal (HP:0010044)2.49828656
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49828656
43Hypoplasia of the pons (HP:0012110)2.49010756
44Large for gestational age (HP:0001520)2.48760996
45Inability to walk (HP:0002540)2.46739063
46Aplasia/Hypoplasia of the patella (HP:0006498)2.45767928
47Concave nail (HP:0001598)2.43774526
48Small intestinal stenosis (HP:0012848)2.42290743
49Duodenal stenosis (HP:0100867)2.42290743
50Embryonal renal neoplasm (HP:0011794)2.40631489
51Syringomyelia (HP:0003396)2.38842592
52Spinal cord lesions (HP:0100561)2.38842592
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.38800840
54Nephrogenic diabetes insipidus (HP:0009806)2.38320906
55Genital tract atresia (HP:0001827)2.37536603
56Severe muscular hypotonia (HP:0006829)2.37334906
57Nephroblastoma (Wilms tumor) (HP:0002667)2.35666687
58Myelodysplasia (HP:0002863)2.34979153
59Selective tooth agenesis (HP:0001592)2.33891971
60Pachygyria (HP:0001302)2.31787742
61Vaginal atresia (HP:0000148)2.31048255
62Abnormality of the calcaneus (HP:0008364)2.26612265
63Chronic hepatic failure (HP:0100626)2.26584929
64Abnormality of the pons (HP:0007361)2.25003032
65Congenital, generalized hypertrichosis (HP:0004540)2.23968290
66Congenital hepatic fibrosis (HP:0002612)2.23946883
67Reticulocytopenia (HP:0001896)2.23706397
68Acute myeloid leukemia (HP:0004808)2.23066719
69Progressive inability to walk (HP:0002505)2.22005942
70Chorioretinal atrophy (HP:0000533)2.21959770
71Irregular epiphyses (HP:0010582)2.21589068
72Mesomelia (HP:0003027)2.21381244
73Delayed gross motor development (HP:0002194)2.20829118
74Type 2 muscle fiber atrophy (HP:0003554)2.19977023
75Adrenal hypoplasia (HP:0000835)2.18945239
76Postaxial hand polydactyly (HP:0001162)2.18204817
77Nonimmune hydrops fetalis (HP:0001790)2.17966003
78Premature rupture of membranes (HP:0001788)2.16666322
79Postaxial foot polydactyly (HP:0001830)2.16632679
80Hemiparesis (HP:0001269)2.14031389
81Abnormality of dentin (HP:0010299)2.13745301
82Agnosia (HP:0010524)2.12391176
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.10018798
84True hermaphroditism (HP:0010459)2.09606544
85Vertebral compression fractures (HP:0002953)2.07876871
86Attenuation of retinal blood vessels (HP:0007843)2.06961216
87Optic nerve coloboma (HP:0000588)2.06796815
88Bone marrow hypocellularity (HP:0005528)2.05489479
89Mitochondrial inheritance (HP:0001427)2.02163227
90Optic nerve hypoplasia (HP:0000609)2.01010891
91Muscle fiber atrophy (HP:0100295)2.00961173
92Abolished electroretinogram (ERG) (HP:0000550)1.99374331
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98297278
94Short tibia (HP:0005736)1.97204096
95Mild short stature (HP:0003502)1.96289215
96Colon cancer (HP:0003003)1.96187818
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93356694
98Abnormality of alanine metabolism (HP:0010916)1.93356694
99Hyperalaninemia (HP:0003348)1.93356694
100Cervical subluxation (HP:0003308)1.93347731
101Soft skin (HP:0000977)1.93338929
102Long clavicles (HP:0000890)1.93336205
103Preaxial hand polydactyly (HP:0001177)1.93183265
104Abnormality of the renal cortex (HP:0011035)1.92929702
105Tubular atrophy (HP:0000092)1.92922785
106Abnormal number of erythroid precursors (HP:0012131)1.92440931
107Male pseudohermaphroditism (HP:0000037)1.92140532
108Abnormality of the prostate (HP:0008775)1.91756726
109Prostate neoplasm (HP:0100787)1.91745506
110Mesangial abnormality (HP:0001966)1.90477031
111Medulloblastoma (HP:0002885)1.90113346
112Absent/shortened dynein arms (HP:0200106)1.89262186
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.89262186
114Flared metaphyses (HP:0003015)1.89009220
115Pendular nystagmus (HP:0012043)1.88358221
116Broad distal phalanx of finger (HP:0009836)1.88327607
117Ectopic kidney (HP:0000086)1.87895862
118Sloping forehead (HP:0000340)1.87711767
119Petechiae (HP:0000967)1.86948224
120Ketoacidosis (HP:0001993)1.86619670
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86083318
122Abnormal respiratory motile cilium morphology (HP:0005938)1.85824179
123Abnormal respiratory epithelium morphology (HP:0012253)1.85824179
124Polydipsia (HP:0001959)1.85099670
125Abnormal drinking behavior (HP:0030082)1.85099670
126Anophthalmia (HP:0000528)1.84466555
127Abnormality of incisor morphology (HP:0011063)1.84141856
128Decreased skull ossification (HP:0004331)1.83989970
129Deep philtrum (HP:0002002)1.83777910
130Abnormality of the duodenum (HP:0002246)1.82823228
131IgG deficiency (HP:0004315)1.82135776
132Premature graying of hair (HP:0002216)1.80318730
133Spondylolisthesis (HP:0003302)1.80273484
134Biconcave vertebral bodies (HP:0004586)1.80203600
135Abnormality of the incisor (HP:0000676)1.79589149
136Delayed cranial suture closure (HP:0000270)1.78857851
137Absent epiphyses (HP:0010577)1.78564813
138Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78564813
139Bilateral microphthalmos (HP:0007633)1.78156186
1403-Methylglutaconic aciduria (HP:0003535)1.77371558
141Radial bowing (HP:0002986)1.77366357
142Broad metatarsal (HP:0001783)1.76303762
143Clubbing of toes (HP:0100760)1.75848356
144Flat capital femoral epiphysis (HP:0003370)1.75599073
145Entropion (HP:0000621)1.75487850
146Ulnar claw (HP:0001178)1.75080165
147Abnormality of macular pigmentation (HP:0008002)1.74899082
148Calcaneovalgus deformity (HP:0001848)1.73506451
149Aplasia/Hypoplasia of the lens (HP:0008063)1.73417577
150Diastasis recti (HP:0001540)1.73023131
151Adactyly (HP:0009776)1.72774307
152Renal cortical cysts (HP:0000803)1.72414986
153Dandy-Walker malformation (HP:0001305)1.71673058
154Stillbirth (HP:0003826)1.71649879
155Arthropathy (HP:0003040)1.71323094
156Volvulus (HP:0002580)1.71001942
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70765300
158Bladder diverticulum (HP:0000015)1.69834367
159Infantile muscular hypotonia (HP:0008947)1.69518544
160Short middle phalanx of the 5th finger (HP:0004220)1.68653339
161Retinal atrophy (HP:0001105)1.67061943
162Hypoalbuminemia (HP:0003073)1.66392207
163Abnormal albumin level (HP:0012116)1.66392207
164Abnormal rod and cone electroretinograms (HP:0008323)1.65156068
165Lipid accumulation in hepatocytes (HP:0006561)1.64753948
166Bowed forearm bones (HP:0003956)1.64307073
167Bowing of the arm (HP:0006488)1.64307073
168Pancreatic fibrosis (HP:0100732)1.64118068
169Increased CSF lactate (HP:0002490)1.64002362
170Abnormality of cells of the erythroid lineage (HP:0012130)1.63066901
171Poor coordination (HP:0002370)1.62916765
172Furrowed tongue (HP:0000221)1.62476553
173Rhabdomyosarcoma (HP:0002859)1.62449594
174Abnormal number of incisors (HP:0011064)1.62264059
175Megalocornea (HP:0000485)1.62240111
176Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61966354
177Abnormal protein N-linked glycosylation (HP:0012347)1.61966354
178Abnormal protein glycosylation (HP:0012346)1.61966354
179Abnormal glycosylation (HP:0012345)1.61966354
180Pulmonary fibrosis (HP:0002206)1.61393427
181Patchy hypopigmentation of hair (HP:0011365)1.59482896
182Abnormality of DNA repair (HP:0003254)1.59072575
183Aortic dissection (HP:0002647)1.59059665
184Triphalangeal thumb (HP:0001199)1.58731579
185Microretrognathia (HP:0000308)1.58566779
186Abnormality of the fetal cardiovascular system (HP:0010948)1.58429469
187Abnormal umbilical cord blood vessels (HP:0011403)1.58429469
188Single umbilical artery (HP:0001195)1.58429469
189Abnormality of the renal collecting system (HP:0004742)1.57757823
190Impulsivity (HP:0100710)1.57752037
191Supernumerary spleens (HP:0009799)1.55351092
192Abnormality of the columella (HP:0009929)1.54781244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.76278814
2TLK13.41004794
3WNK32.85809651
4ADRBK22.83964177
5FRK2.81198782
6CDC72.80689153
7PLK42.74781776
8MKNK12.73231601
9EIF2AK12.64558608
10TRIM282.59173527
11MAP4K22.56252929
12BRSK22.55297109
13STK162.45971868
14MAPK152.41093313
15WEE12.35265319
16GRK12.32599178
17SIK32.27516919
18SRPK12.19019183
19TAOK32.17466188
20ERBB32.03718535
21PIM22.01485367
22FGFR21.89692756
23WNK41.87928217
24STK241.84489553
25BCKDK1.83659877
26CDK81.78371480
27MAP2K71.78113473
28VRK21.69027547
29MAP3K41.68868707
30MARK11.67237688
31MKNK21.66055889
32EPHB21.62114297
33CDK71.60054939
34NME21.58512328
35VRK11.58163004
36EIF2AK31.51763905
37NUAK11.50058896
38PASK1.48831191
39ACVR1B1.47335091
40STK38L1.46537168
41TXK1.45848243
42CLK11.45578545
43PLK11.42828334
44IRAK41.40447356
45LATS11.40299819
46TGFBR11.38591874
47PLK31.38521552
48ATR1.37275437
49PNCK1.36873610
50TSSK61.36134550
51ADRBK11.32219058
52ZAK1.31111687
53TEC1.30350127
54CSNK1G21.27654460
55MAPK131.26189048
56NEK91.25958731
57CSNK1G31.25218030
58AURKB1.22978660
59TTK1.22718277
60MAP3K61.21846356
61STK31.21839881
62INSRR1.21800630
63BMPR21.19818311
64PAK31.16857158
65NEK21.14712093
66EPHA41.10288589
67CHEK21.09939576
68NTRK21.09509068
69TRPM71.07706621
70PRPF4B1.07586942
71BRSK11.07100861
72CSNK1G11.03958955
73KIT1.02707334
74STK101.02693439
75EIF2AK21.02144062
76BRAF1.01790602
77CSNK1A1L1.01491034
78PTK2B1.00335523
79YES11.00287460
80PINK11.00176398
81TNIK0.99982216
82PAK60.99216937
83MYLK0.98410879
84BCR0.96525236
85MUSK0.95557153
86RPS6KA50.95003655
87PIM10.90701632
88CCNB10.89207681
89PAK40.87659564
90TNK20.86960626
91PLK20.86821667
92MAP3K140.86609649
93CDK30.85753655
94RPS6KA40.84552808
95PIK3CG0.82810128
96BTK0.80387391
97SIK20.80238871
98LIMK10.79542908
99RPS6KC10.78408623
100RPS6KL10.78408623
101TESK20.76540893
102AURKA0.76042828
103STK40.75250824
104MAP3K80.73190890
105MAP4K10.71552154
106MARK30.70663818
107MAPKAPK30.69742513
108FLT30.69062359
109RPS6KA60.68718115
110PRKCG0.68272478
111MAP2K30.65911897
112ARAF0.65712586
113PRKCE0.64694962
114MAP3K120.64348739
115CDK40.63451657
116TIE10.61992766
117CSNK2A10.61208974
118CSF1R0.60360684
119RPS6KB20.59816791
120MST40.59470696
121ATM0.59223941
122BMPR1B0.58339322
123CHEK10.55423951
124MOS0.53419969
125OXSR10.52435246
126PRKCQ0.51519954
127NME10.50578716
128PBK0.49755958
129RAF10.49434539
130DYRK20.48428834
131NTRK30.48324733
132TESK10.47799267
133GRK70.46870082
134NLK0.45812062
135LATS20.45328818
136PAK10.44273122
137DAPK20.43305696
138CAMKK20.42953579
139ITK0.42909555
140CASK0.42572864
141PHKG10.42402882
142PHKG20.42402882
143CAMK2A0.42370729
144PRKACA0.42147225
145DYRK30.41169520
146NEK60.41052830
147ZAP700.40972422
148IKBKB0.40967380
149CDK190.40578894
150NEK10.40378733
151LRRK20.40231818
152CDK10.39914521
153KDR0.39682388
154ABL20.39455246
155CDK20.39106130
156EPHA30.38231404
157GRK60.36428772
158CSNK1D0.35326633
159NTRK10.33475855
160MAPKAPK50.33428682
161PIK3CA0.32223117
162STK110.31633652
163CSNK1A10.29994785
164FES0.27964935
165MAP2K40.27694281
166PKN10.27354647
167ROCK10.27236454

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34551294
2Mismatch repair_Homo sapiens_hsa034303.69696706
3Base excision repair_Homo sapiens_hsa034103.08863754
4Oxidative phosphorylation_Homo sapiens_hsa001902.99567231
5Homologous recombination_Homo sapiens_hsa034402.98656022
6RNA polymerase_Homo sapiens_hsa030202.90689111
7Cell cycle_Homo sapiens_hsa041102.86470629
8Nucleotide excision repair_Homo sapiens_hsa034202.81938084
9Proteasome_Homo sapiens_hsa030502.80804744
10Phototransduction_Homo sapiens_hsa047442.76273980
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.64122091
12Non-homologous end-joining_Homo sapiens_hsa034502.60448501
13Nitrogen metabolism_Homo sapiens_hsa009102.57723434
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.54827257
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.52950199
16Ribosome_Homo sapiens_hsa030102.49613791
17Spliceosome_Homo sapiens_hsa030402.44807861
18Fanconi anemia pathway_Homo sapiens_hsa034602.33984965
19Sulfur relay system_Homo sapiens_hsa041222.32943708
20RNA transport_Homo sapiens_hsa030132.25354685
21Basal transcription factors_Homo sapiens_hsa030222.23407923
22RNA degradation_Homo sapiens_hsa030182.20022353
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17360914
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17299130
25Pyrimidine metabolism_Homo sapiens_hsa002402.15953564
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14387427
27Protein export_Homo sapiens_hsa030602.14258393
28Linoleic acid metabolism_Homo sapiens_hsa005912.04888849
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96548211
30Butanoate metabolism_Homo sapiens_hsa006501.94266839
31Nicotine addiction_Homo sapiens_hsa050331.79811239
32p53 signaling pathway_Homo sapiens_hsa041151.77987411
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77257706
34Ether lipid metabolism_Homo sapiens_hsa005651.60296594
35Selenocompound metabolism_Homo sapiens_hsa004501.60141348
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52644892
37Alzheimers disease_Homo sapiens_hsa050101.52422160
38Regulation of autophagy_Homo sapiens_hsa041401.48959428
39One carbon pool by folate_Homo sapiens_hsa006701.46146766
40mRNA surveillance pathway_Homo sapiens_hsa030151.40476058
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36735120
42Cardiac muscle contraction_Homo sapiens_hsa042601.35529059
43Hedgehog signaling pathway_Homo sapiens_hsa043401.33683729
44Purine metabolism_Homo sapiens_hsa002301.33364347
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23983662
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21794301
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21336585
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18976276
49Taste transduction_Homo sapiens_hsa047421.10505291
50Tryptophan metabolism_Homo sapiens_hsa003801.10144480
51Epstein-Barr virus infection_Homo sapiens_hsa051691.10104714
52Axon guidance_Homo sapiens_hsa043601.07865620
53Steroid biosynthesis_Homo sapiens_hsa001001.07183391
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96694306
55Peroxisome_Homo sapiens_hsa041460.94522211
56Herpes simplex infection_Homo sapiens_hsa051680.94350453
57Thyroid cancer_Homo sapiens_hsa052160.93672236
58N-Glycan biosynthesis_Homo sapiens_hsa005100.90630175
59Arachidonic acid metabolism_Homo sapiens_hsa005900.89501033
60Antigen processing and presentation_Homo sapiens_hsa046120.89265689
61Shigellosis_Homo sapiens_hsa051310.88568665
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87581907
63TGF-beta signaling pathway_Homo sapiens_hsa043500.87019934
64Cocaine addiction_Homo sapiens_hsa050300.86684578
65Viral carcinogenesis_Homo sapiens_hsa052030.86143821
66Morphine addiction_Homo sapiens_hsa050320.85671490
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83726891
68MicroRNAs in cancer_Homo sapiens_hsa052060.83070886
69Malaria_Homo sapiens_hsa051440.80306368
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80259767
71Primary immunodeficiency_Homo sapiens_hsa053400.78642700
72HTLV-I infection_Homo sapiens_hsa051660.78029114
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77350290
74Propanoate metabolism_Homo sapiens_hsa006400.77236040
75Oocyte meiosis_Homo sapiens_hsa041140.77148396
76Insulin secretion_Homo sapiens_hsa049110.76606847
77Small cell lung cancer_Homo sapiens_hsa052220.72474625
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72285488
79Folate biosynthesis_Homo sapiens_hsa007900.72119005
80Viral myocarditis_Homo sapiens_hsa054160.71722250
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70942323
82Measles_Homo sapiens_hsa051620.69970495
83Legionellosis_Homo sapiens_hsa051340.67804900
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66439065
85Apoptosis_Homo sapiens_hsa042100.66198385
86Caffeine metabolism_Homo sapiens_hsa002320.65790093
87Sulfur metabolism_Homo sapiens_hsa009200.65322117
88ECM-receptor interaction_Homo sapiens_hsa045120.63821845
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62061083
90Protein digestion and absorption_Homo sapiens_hsa049740.60180399
91Hepatitis B_Homo sapiens_hsa051610.58229093
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.58059879
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58054123
94Fatty acid elongation_Homo sapiens_hsa000620.57759695
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.57363386
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.56896316
97Glutathione metabolism_Homo sapiens_hsa004800.56699904
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54461444
99Hematopoietic cell lineage_Homo sapiens_hsa046400.54299294
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54239701
101Collecting duct acid secretion_Homo sapiens_hsa049660.53417598
102Colorectal cancer_Homo sapiens_hsa052100.53363484
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53219742
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52592002
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52465734
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51965337
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51526006
108Metabolic pathways_Homo sapiens_hsa011000.50390367
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50144812
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50077268
111Hippo signaling pathway_Homo sapiens_hsa043900.49431132
112Pancreatic cancer_Homo sapiens_hsa052120.47743190
113Ovarian steroidogenesis_Homo sapiens_hsa049130.47329201
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.46658826
115Systemic lupus erythematosus_Homo sapiens_hsa053220.46508350
116Dopaminergic synapse_Homo sapiens_hsa047280.46054907
117Serotonergic synapse_Homo sapiens_hsa047260.46014444
118GABAergic synapse_Homo sapiens_hsa047270.45588831
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45203684
120Pathways in cancer_Homo sapiens_hsa052000.44897910
121Huntingtons disease_Homo sapiens_hsa050160.44221611
122Chemical carcinogenesis_Homo sapiens_hsa052040.44169258
123Leishmaniasis_Homo sapiens_hsa051400.43954401
124Phagosome_Homo sapiens_hsa041450.43125272
125Circadian entrainment_Homo sapiens_hsa047130.42914978
126Prostate cancer_Homo sapiens_hsa052150.42901371
127ABC transporters_Homo sapiens_hsa020100.42773165
128Other glycan degradation_Homo sapiens_hsa005110.42554142
129Basal cell carcinoma_Homo sapiens_hsa052170.41257110
130Chronic myeloid leukemia_Homo sapiens_hsa052200.40574700
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40065377
132Focal adhesion_Homo sapiens_hsa045100.39726707
133Melanoma_Homo sapiens_hsa052180.38667032
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.38449318
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38352690
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37663593
137Influenza A_Homo sapiens_hsa051640.37601568
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.37410540
139Ras signaling pathway_Homo sapiens_hsa040140.37398500
140Adherens junction_Homo sapiens_hsa045200.36182623
141Notch signaling pathway_Homo sapiens_hsa043300.36149055
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34148361
143Sphingolipid metabolism_Homo sapiens_hsa006000.33151667
144Allograft rejection_Homo sapiens_hsa053300.33012279
145Platelet activation_Homo sapiens_hsa046110.32478070
146Olfactory transduction_Homo sapiens_hsa047400.30856954
147Pertussis_Homo sapiens_hsa051330.29368126
148Glutamatergic synapse_Homo sapiens_hsa047240.28432870
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28200452
150Rheumatoid arthritis_Homo sapiens_hsa053230.27739221
151Wnt signaling pathway_Homo sapiens_hsa043100.25489240
152Toxoplasmosis_Homo sapiens_hsa051450.25155272
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24230721
154Amphetamine addiction_Homo sapiens_hsa050310.23943112
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23831632
156Parkinsons disease_Homo sapiens_hsa050120.23828401
157Galactose metabolism_Homo sapiens_hsa000520.23764036
158Graft-versus-host disease_Homo sapiens_hsa053320.23441676
159Salmonella infection_Homo sapiens_hsa051320.22943862
160Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22783780
161Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22082623
162Autoimmune thyroid disease_Homo sapiens_hsa053200.21009060

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