CNR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)7.83488429
2neuron cell-cell adhesion (GO:0007158)7.56228286
3pyrimidine nucleobase catabolic process (GO:0006208)6.38144469
4positive regulation of synapse maturation (GO:0090129)6.35482982
5succinate metabolic process (GO:0006105)6.17432691
6neurotransmitter-gated ion channel clustering (GO:0072578)6.16083279
7startle response (GO:0001964)5.92012962
8gamma-aminobutyric acid transport (GO:0015812)5.73752706
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.64001855
10regulation of synapse maturation (GO:0090128)5.50224309
11synaptic vesicle exocytosis (GO:0016079)5.49052593
12negative regulation of synaptic transmission, GABAergic (GO:0032229)5.39440218
13regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18988615
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.15711041
15protein localization to synapse (GO:0035418)5.10820009
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05735936
17cell migration in hindbrain (GO:0021535)5.04574673
18neurotransmitter secretion (GO:0007269)5.03769806
19regulation of glutamate receptor signaling pathway (GO:1900449)5.02209299
20nucleobase catabolic process (GO:0046113)5.00763588
21auditory behavior (GO:0031223)4.83312248
22neuronal action potential propagation (GO:0019227)4.72913441
23layer formation in cerebral cortex (GO:0021819)4.72323098
24central nervous system projection neuron axonogenesis (GO:0021952)4.71055345
25proline transport (GO:0015824)4.46920356
26positive regulation of synapse assembly (GO:0051965)4.36840873
27establishment of mitochondrion localization (GO:0051654)4.34164193
28regulation of synapse structural plasticity (GO:0051823)4.32016338
29regulation of synaptic vesicle exocytosis (GO:2000300)4.31367065
30mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.29784511
31transferrin transport (GO:0033572)4.23803044
32striatum development (GO:0021756)4.23516356
33ATP hydrolysis coupled proton transport (GO:0015991)4.22838633
34energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.22838633
35presynaptic membrane assembly (GO:0097105)4.18904015
36gamma-aminobutyric acid signaling pathway (GO:0007214)4.16670376
37positive regulation of dendritic spine morphogenesis (GO:0061003)4.15069674
38dendrite morphogenesis (GO:0048813)4.12628866
39response to auditory stimulus (GO:0010996)4.12188893
40protein-cofactor linkage (GO:0018065)4.11123586
41postsynaptic membrane organization (GO:0001941)4.01631320
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01342903
43limb bud formation (GO:0060174)4.00757605
44neuron-neuron synaptic transmission (GO:0007270)3.99741122
45trivalent inorganic cation transport (GO:0072512)3.99433304
46ferric iron transport (GO:0015682)3.99433304
47regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.98257219
48dendritic spine morphogenesis (GO:0060997)3.98170011
49synaptic vesicle maturation (GO:0016188)3.97142512
50neurotransmitter transport (GO:0006836)3.96641977
51cerebral cortex radially oriented cell migration (GO:0021799)3.95840465
52locomotory exploration behavior (GO:0035641)3.93849693
53positive regulation of action potential (GO:0045760)3.93033955
54mechanosensory behavior (GO:0007638)3.89525822
55long-term synaptic potentiation (GO:0060291)3.83611083
56regulation of synaptic vesicle transport (GO:1902803)3.82409288
57cerebellar granule cell differentiation (GO:0021707)3.81067649
58presynaptic membrane organization (GO:0097090)3.77226516
59behavioral response to cocaine (GO:0048148)3.74152792
60prostate gland growth (GO:0060736)3.72735776
61neuron recognition (GO:0008038)3.69465776
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.69450790
63mitochondrion transport along microtubule (GO:0047497)3.69450790
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.64581032
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.64558039
66negative regulation of dendrite morphogenesis (GO:0050774)3.64014904
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.64011637
68dicarboxylic acid catabolic process (GO:0043649)3.63095132
69synaptic transmission, glutamatergic (GO:0035249)3.62123897
70detection of calcium ion (GO:0005513)3.61722988
71positive regulation of amino acid transport (GO:0051957)3.61506664
72regulation of axon guidance (GO:1902667)3.61476288
73central nervous system neuron axonogenesis (GO:0021955)3.59436575
74exploration behavior (GO:0035640)3.59184988
75regulation of neurotransmitter levels (GO:0001505)3.57084975
76glutamate secretion (GO:0014047)3.51062709
77positive regulation of membrane potential (GO:0045838)3.50647224
78learning (GO:0007612)3.48090525
79synapse assembly (GO:0007416)3.47565992
80regulation of axon extension involved in axon guidance (GO:0048841)3.45121428
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44510534
82nerve growth factor signaling pathway (GO:0038180)3.44368135
83regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43439544
84regulation of glutamate secretion (GO:0014048)3.41819214
85regulation of dendritic spine morphogenesis (GO:0061001)3.39639043
86membrane assembly (GO:0071709)3.36047556
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34859726
88maternal behavior (GO:0042711)3.32860709
89positive regulation of dendritic spine development (GO:0060999)3.32784837
90response to histamine (GO:0034776)3.32741509
91long-term memory (GO:0007616)3.32546785
92neurotransmitter biosynthetic process (GO:0042136)3.31802781
93neuronal ion channel clustering (GO:0045161)3.31353615
94regulation of neuronal synaptic plasticity (GO:0048168)3.29317423
95regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26325209
96regulation of synapse assembly (GO:0051963)3.26075003
97glycerophospholipid catabolic process (GO:0046475)3.26037681
98multicellular organismal reproductive behavior (GO:0033057)3.24616458
99regulation of female receptivity (GO:0045924)3.24585437
100axon extension (GO:0048675)3.23223307
101retinal ganglion cell axon guidance (GO:0031290)3.23048562
102social behavior (GO:0035176)3.22148680
103intraspecies interaction between organisms (GO:0051703)3.22148680
104regulation of synaptic plasticity (GO:0048167)3.20532808
105* regulation of synaptic transmission, glutamatergic (GO:0051966)3.20332846
106* response to cocaine (GO:0042220)3.20298082
107neuron migration (GO:0001764)3.20210876
108neuron fate determination (GO:0048664)3.18962492
109female mating behavior (GO:0060180)3.18085958
110* regulation of synaptic transmission, GABAergic (GO:0032228)3.14540134
111regulation of postsynaptic membrane potential (GO:0060078)3.13555027
112regulation of protein kinase A signaling (GO:0010738)3.13403973
113behavioral response to nicotine (GO:0035095)3.13248919
114neurotransmitter metabolic process (GO:0042133)3.13041517
115axonal fasciculation (GO:0007413)3.11803700
116short-term memory (GO:0007614)3.11467402
117glutamate receptor signaling pathway (GO:0007215)3.10739054
118transmission of nerve impulse (GO:0019226)3.10163637
119cerebral cortex cell migration (GO:0021795)3.09465518
120synaptic vesicle endocytosis (GO:0048488)3.08216138
121positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.06985092
122negative regulation of dendrite development (GO:2000171)3.06937609
123synaptic vesicle docking involved in exocytosis (GO:0016081)3.06673937
124* regulation of penile erection (GO:0060405)3.04243234
125phagosome maturation (GO:0090382)3.03784544
126positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03663200
127neuromuscular synaptic transmission (GO:0007274)3.03111858
128behavioral defense response (GO:0002209)3.03023418
129behavioral fear response (GO:0001662)3.03023418
130serotonin receptor signaling pathway (GO:0007210)3.00715420
131regulation of dendritic spine development (GO:0060998)3.00340802
132axonogenesis (GO:0007409)2.99715572
133positive regulation of cardiac muscle hypertrophy (GO:0010613)2.98861349
134positive regulation of muscle hypertrophy (GO:0014742)2.98861349
135negative regulation of neurotransmitter transport (GO:0051589)2.96897106
136visual learning (GO:0008542)2.96847737
137positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96800723
138regulation of respiratory system process (GO:0044065)2.96794222
139synapse organization (GO:0050808)2.96524356
140heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.94567880
141calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.89123551
142membrane depolarization during action potential (GO:0086010)2.88721526
143negative regulation of axon extension (GO:0030517)2.84953512
144membrane depolarization (GO:0051899)2.84522809
145regulation of synapse organization (GO:0050807)2.83779125
146neuron projection extension (GO:1990138)2.79200746
147regulation of dendrite morphogenesis (GO:0048814)2.78910748
148positive regulation of dendrite morphogenesis (GO:0050775)2.78083263
149negative regulation of axonogenesis (GO:0050771)2.76130598
150organelle transport along microtubule (GO:0072384)2.76043242
151regulation of axon extension (GO:0030516)2.75458580
152regulation of dendrite development (GO:0050773)2.75333798
153cellular potassium ion homeostasis (GO:0030007)2.74871429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40239224
2GBX2_23144817_ChIP-Seq_PC3_Human5.12902505
3TAF15_26573619_Chip-Seq_HEK293_Human3.26906016
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96253243
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91054038
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80773891
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80497981
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66994792
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66506962
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.48766482
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45588464
12REST_21632747_ChIP-Seq_MESCs_Mouse2.40968651
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34677395
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34636245
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.24898985
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23767743
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23001238
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23001238
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.22619088
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16477642
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15005934
22* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14344005
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07442412
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07101203
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06787195
26P300_19829295_ChIP-Seq_ESCs_Human2.05691990
27SMAD4_21799915_ChIP-Seq_A2780_Human2.03499351
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.03044747
29* EED_16625203_ChIP-ChIP_MESCs_Mouse1.96438388
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91713278
31FUS_26573619_Chip-Seq_HEK293_Human1.90214750
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88085238
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84342646
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83759963
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81860795
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.81815881
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.77259328
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.75960562
39ER_23166858_ChIP-Seq_MCF-7_Human1.72078283
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71988524
41* RNF2_27304074_Chip-Seq_ESCs_Mouse1.70739498
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68691076
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67463357
44AR_21572438_ChIP-Seq_LNCaP_Human1.67041958
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.61498849
46* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58645950
47* RARB_27405468_Chip-Seq_BRAIN_Mouse1.57892775
48DROSHA_22980978_ChIP-Seq_HELA_Human1.57595209
49IGF1R_20145208_ChIP-Seq_DFB_Human1.56009856
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55950566
51AR_25329375_ChIP-Seq_VCAP_Human1.52056393
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.51077389
53RNF2_27304074_Chip-Seq_NSC_Mouse1.49926390
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49181213
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48850330
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48850330
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43737228
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40802648
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40254953
60ZNF274_21170338_ChIP-Seq_K562_Hela1.35745863
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.34871279
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34613382
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34594268
64JUN_21703547_ChIP-Seq_K562_Human1.31954372
65AHR_22903824_ChIP-Seq_MCF-7_Human1.30389354
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29208035
67STAT3_23295773_ChIP-Seq_U87_Human1.28890893
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26614711
69LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26014178
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.25570626
71* ARNT_22903824_ChIP-Seq_MCF-7_Human1.25226201
72TCF4_23295773_ChIP-Seq_U87_Human1.23965309
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23311378
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22542142
75* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20207377
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.19481822
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19377794
78* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19103261
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18620386
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.17964387
81RUNX2_22187159_ChIP-Seq_PCA_Human1.16531981
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16322571
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16189844
84* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15873095
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14446568
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13626670
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12012463
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11109518
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11040585
90KDM2B_26808549_Chip-Seq_REH_Human1.09192054
91VDR_22108803_ChIP-Seq_LS180_Human1.08743930
92EWS_26573619_Chip-Seq_HEK293_Human1.07745613
93* AR_19668381_ChIP-Seq_PC3_Human1.07564674
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07375125
95CBP_20019798_ChIP-Seq_JUKART_Human1.07375125
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05930940
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05263300
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.05127714
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04695151
100* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04483694
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03951646
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03565940
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03310480
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03045510
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.02997018
106SOX9_26525672_Chip-Seq_HEART_Mouse1.02746413
107* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01040308
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00917473
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00484632
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00357505
111BCAT_22108803_ChIP-Seq_LS180_Human0.98589502
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.97599485
113ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97556255
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96818681
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95272525
116RING1B_27294783_Chip-Seq_ESCs_Mouse0.94527786
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94456490
118TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94360954
119TP53_18474530_ChIP-ChIP_U2OS_Human0.93815226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.81215592
2MP0009046_muscle_twitch3.88062187
3* MP0003635_abnormal_synaptic_transmissio3.86513869
4* MP0009745_abnormal_behavioral_response3.71171485
5* MP0002064_seizures3.61914050
6MP0003880_abnormal_central_pattern3.35424502
7* MP0002063_abnormal_learning/memory/cond3.24705919
8* MP0002572_abnormal_emotion/affect_behav2.98149880
9MP0002837_dystrophic_cardiac_calcinosis2.95277479
10MP0003787_abnormal_imprinting2.83752296
11MP0002272_abnormal_nervous_system2.69400135
12MP0001486_abnormal_startle_reflex2.58073854
13MP0001188_hyperpigmentation2.40560382
14MP0002734_abnormal_mechanical_nocicepti2.37568480
15MP0009780_abnormal_chondrocyte_physiolo2.36130556
16MP0001968_abnormal_touch/_nociception2.33944915
17MP0005423_abnormal_somatic_nervous2.32490097
18MP0006276_abnormal_autonomic_nervous2.29789650
19MP0005646_abnormal_pituitary_gland2.29006897
20MP0001501_abnormal_sleep_pattern2.24729241
21MP0000569_abnormal_digit_pigmentation2.20762035
22MP0002736_abnormal_nociception_after2.17073036
23MP0002067_abnormal_sensory_capabilities2.11743109
24* MP0002735_abnormal_chemical_nociception2.11422526
25MP0004270_analgesia2.05800378
26MP0002184_abnormal_innervation2.01621928
27MP0001984_abnormal_olfaction2.00861630
28MP0010386_abnormal_urinary_bladder1.95332928
29MP0003122_maternal_imprinting1.92859601
30MP0002876_abnormal_thyroid_physiology1.88919353
31MP0008569_lethality_at_weaning1.85298780
32MP0002557_abnormal_social/conspecific_i1.83888091
33MP0001440_abnormal_grooming_behavior1.79800581
34MP0003329_amyloid_beta_deposits1.67301649
35MP0000778_abnormal_nervous_system1.66287424
36MP0001986_abnormal_taste_sensitivity1.61561782
37* MP0001970_abnormal_pain_threshold1.54496006
38MP0004142_abnormal_muscle_tone1.52380788
39MP0004885_abnormal_endolymph1.51616115
40* MP0004811_abnormal_neuron_physiology1.51177463
41MP0005187_abnormal_penis_morphology1.49464222
42* MP0002066_abnormal_motor_capabilities/c1.45301915
43MP0002102_abnormal_ear_morphology1.44220948
44MP0005171_absent_coat_pigmentation1.44013386
45MP0003879_abnormal_hair_cell1.39338458
46MP0001529_abnormal_vocalization1.36593372
47MP0002751_abnormal_autonomic_nervous1.32917894
48MP0003136_yellow_coat_color1.32024731
49MP0001177_atelectasis1.30337921
50* MP0005386_behavior/neurological_phenoty1.30308472
51* MP0004924_abnormal_behavior1.30308472
52MP0000955_abnormal_spinal_cord1.27338816
53* MP0002882_abnormal_neuron_morphology1.26367732
54* MP0003861_abnormal_nervous_system1.25056453
55* MP0002733_abnormal_thermal_nociception1.20961482
56MP0001905_abnormal_dopamine_level1.20797049
57MP0003121_genomic_imprinting1.19694925
58MP0003890_abnormal_embryonic-extraembry1.18176411
59MP0008877_abnormal_DNA_methylation1.16286118
60MP0000013_abnormal_adipose_tissue1.16152695
61MP0003632_abnormal_nervous_system1.13568177
62* MP0002822_catalepsy1.13495642
63MP0003123_paternal_imprinting1.12677049
64MP0002909_abnormal_adrenal_gland1.11541998
65MP0004147_increased_porphyrin_level1.11219008
66MP0001270_distended_abdomen1.10673266
67MP0004085_abnormal_heartbeat1.10370732
68MP0005394_taste/olfaction_phenotype1.09928273
69MP0005499_abnormal_olfactory_system1.09928273
70MP0000534_abnormal_ureter_morphology1.08437486
71MP0003631_nervous_system_phenotype1.07874179
72MP0004215_abnormal_myocardial_fiber1.07572654
73MP0003183_abnormal_peptide_metabolism1.05313527
74MP0006292_abnormal_olfactory_placode1.05263798
75MP0001963_abnormal_hearing_physiology1.03409248
76* MP0002152_abnormal_brain_morphology1.02632309
77MP0002638_abnormal_pupillary_reflex1.02245558
78MP0003633_abnormal_nervous_system1.01475500
79MP0005248_abnormal_Harderian_gland1.01014426
80MP0000751_myopathy0.98163424
81* MP0002069_abnormal_eating/drinking_beha0.97442346
82MP0000604_amyloidosis0.89193936
83MP0002081_perinatal_lethality0.87659731
84MP0002653_abnormal_ependyma_morphology0.86791243
85MP0008789_abnormal_olfactory_epithelium0.84657143
86MP0001485_abnormal_pinna_reflex0.84524386
87MP0001664_abnormal_digestion0.84203282
88MP0005645_abnormal_hypothalamus_physiol0.84157066
89MP0002229_neurodegeneration0.83669301
90MP0003938_abnormal_ear_development0.81920969
91MP0005551_abnormal_eye_electrophysiolog0.80792574
92MP0005367_renal/urinary_system_phenotyp0.80685071
93MP0000516_abnormal_urinary_system0.80685071
94MP0003283_abnormal_digestive_organ0.78635183
95MP0000049_abnormal_middle_ear0.78180840
96MP0005195_abnormal_posterior_eye0.77337162
97MP0004484_altered_response_of0.76495312
98MP0003646_muscle_fatigue0.75373418
99MP0002233_abnormal_nose_morphology0.74919817
100MP0002752_abnormal_somatic_nervous0.74800548
101MP0004043_abnormal_pH_regulation0.74637922
102MP0004742_abnormal_vestibular_system0.74096912
103* MP0010769_abnormal_survival0.73599222
104MP0004133_heterotaxia0.73250697
105MP0001502_abnormal_circadian_rhythm0.72810218
106MP0002234_abnormal_pharynx_morphology0.72100215
107MP0000026_abnormal_inner_ear0.71524140
108MP0004233_abnormal_muscle_weight0.70808116
109MP0001299_abnormal_eye_distance/0.70647898
110* MP0010768_mortality/aging0.69941896
111MP0005253_abnormal_eye_physiology0.69823481
112* MP0002082_postnatal_lethality0.69331911
113* MP0010770_preweaning_lethality0.69331911
114MP0003755_abnormal_palate_morphology0.69131243
115MP0000537_abnormal_urethra_morphology0.69089158
116MP0005595_abnormal_vascular_smooth0.68811511
117MP0008874_decreased_physiological_sensi0.68150427
118MP0003119_abnormal_digestive_system0.67979375
119MP0003690_abnormal_glial_cell0.67316977
120MP0003634_abnormal_glial_cell0.67223414
121MP0003137_abnormal_impulse_conducting0.67081984
122MP0002108_abnormal_muscle_morphology0.66911703
123MP0000647_abnormal_sebaceous_gland0.66045833
124MP0000631_abnormal_neuroendocrine_gland0.65021630
125MP0002332_abnormal_exercise_endurance0.64868150
126MP0001943_abnormal_respiration0.64100573
127MP0000681_abnormal_thyroid_gland0.62633745

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.49571062
2Hyperventilation (HP:0002883)8.02670672
3Atonic seizures (HP:0010819)6.37718882
4Febrile seizures (HP:0002373)5.59680602
5Epileptic encephalopathy (HP:0200134)5.19477927
6Progressive inability to walk (HP:0002505)4.99199672
7Focal seizures (HP:0007359)4.79691541
8Absence seizures (HP:0002121)4.43105416
9Dialeptic seizures (HP:0011146)4.18627322
10Abnormal hair whorl (HP:0010721)3.94095578
11Broad-based gait (HP:0002136)3.72710327
12Generalized tonic-clonic seizures (HP:0002069)3.54106870
13Inability to walk (HP:0002540)3.45720458
14Protruding tongue (HP:0010808)3.35874198
15Visual hallucinations (HP:0002367)3.33318253
16Gait imbalance (HP:0002141)3.31449091
17Abnormal mitochondria in muscle tissue (HP:0008316)3.28146689
18Acute necrotizing encephalopathy (HP:0006965)3.23261859
19Absent speech (HP:0001344)3.20988768
20Abnormal social behavior (HP:0012433)3.16488914
21Impaired social interactions (HP:0000735)3.16488914
22Medial flaring of the eyebrow (HP:0010747)3.14697425
23Gaze-evoked nystagmus (HP:0000640)3.13511451
24Progressive cerebellar ataxia (HP:0002073)3.12717250
25Myokymia (HP:0002411)3.10823264
26Action tremor (HP:0002345)3.07302080
27Hemiparesis (HP:0001269)3.06645168
28Polyphagia (HP:0002591)3.06487534
29Congenital primary aphakia (HP:0007707)3.05916165
30Impaired vibration sensation in the lower limbs (HP:0002166)2.99375978
31Abnormality of binocular vision (HP:0011514)2.99171344
32Diplopia (HP:0000651)2.99171344
33Megalencephaly (HP:0001355)2.97174703
34Abnormality of the corticospinal tract (HP:0002492)2.90072092
35Truncal ataxia (HP:0002078)2.89940860
36Excessive salivation (HP:0003781)2.89771855
37Drooling (HP:0002307)2.89771855
38Progressive macrocephaly (HP:0004481)2.87769338
39Poor suck (HP:0002033)2.84027330
40Resting tremor (HP:0002322)2.82284611
41Nephrogenic diabetes insipidus (HP:0009806)2.80990939
42Blue irides (HP:0000635)2.80269475
43Poor eye contact (HP:0000817)2.78227013
44Spastic diplegia (HP:0001264)2.70949966
45Lissencephaly (HP:0001339)2.70441863
46Urinary urgency (HP:0000012)2.70219460
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.66410481
48Fair hair (HP:0002286)2.65729602
49Pheochromocytoma (HP:0002666)2.65602843
50Hepatoblastoma (HP:0002884)2.63691566
51Thickened helices (HP:0000391)2.62557832
52Pachygyria (HP:0001302)2.59579936
53Abnormality of the labia minora (HP:0012880)2.59121533
54Failure to thrive in infancy (HP:0001531)2.57994199
55Spastic gait (HP:0002064)2.57715913
56Acute encephalopathy (HP:0006846)2.55620079
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51129169
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.51129169
59Epileptiform EEG discharges (HP:0011182)2.51117832
60Urinary bladder sphincter dysfunction (HP:0002839)2.47818968
61Ankle clonus (HP:0011448)2.47461653
62Neuroendocrine neoplasm (HP:0100634)2.46216154
63Hyperthyroidism (HP:0000836)2.46173862
64Poor coordination (HP:0002370)2.44979468
65Abnormal eating behavior (HP:0100738)2.43583233
66Hypsarrhythmia (HP:0002521)2.42833845
67Hemiplegia (HP:0002301)2.42252106
68EEG with generalized epileptiform discharges (HP:0011198)2.42052657
69Complete atrioventricular canal defect (HP:0001674)2.41234950
70Dysdiadochokinesis (HP:0002075)2.39527925
71Genital tract atresia (HP:0001827)2.37852869
72Generalized hypopigmentation of hair (HP:0011358)2.36026017
73Vaginal atresia (HP:0000148)2.35580505
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.34546637
75Hypoplasia of the brainstem (HP:0002365)2.34546637
76Exotropia (HP:0000577)2.31995860
77Horizontal nystagmus (HP:0000666)2.31661945
78Cortical dysplasia (HP:0002539)2.29463721
79Split foot (HP:0001839)2.29057647
80Oligomenorrhea (HP:0000876)2.27662683
81Short 4th metacarpal (HP:0010044)2.26611637
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26611637
83Genetic anticipation (HP:0003743)2.24224567
84Esophageal neoplasm (HP:0100751)2.22043162
85Neoplasm of head and neck (HP:0012288)2.22043162
86Hypoplasia of the corpus callosum (HP:0002079)2.21932662
87Status epilepticus (HP:0002133)2.21038966
88Mitochondrial inheritance (HP:0001427)2.19025410
89Spastic tetraplegia (HP:0002510)2.18871081
90Scanning speech (HP:0002168)2.18587129
91Specific learning disability (HP:0001328)2.18508603
92Agitation (HP:0000713)2.18333594
93Amyotrophic lateral sclerosis (HP:0007354)2.15914603
94Dysmetric saccades (HP:0000641)2.15053449
95Atrioventricular canal defect (HP:0006695)2.11711762
96Narrow nasal bridge (HP:0000446)2.07684675
97Retinal dysplasia (HP:0007973)2.07608337
98Vitreoretinal degeneration (HP:0000655)2.06555244
99Neoplasm of the peripheral nervous system (HP:0100007)2.05922555
100Lower limb muscle weakness (HP:0007340)2.05455273
101Abnormality of the lower motor neuron (HP:0002366)2.05138912
102Fetal akinesia sequence (HP:0001989)2.04679800
103Cutaneous finger syndactyly (HP:0010554)2.04465666
104Shoulder girdle muscle weakness (HP:0003547)2.02857959
105Gait ataxia (HP:0002066)1.98785831
106Anxiety (HP:0000739)1.98384054
107Medulloblastoma (HP:0002885)1.97121805
108Abnormality of salivation (HP:0100755)1.96905433
109Generalized myoclonic seizures (HP:0002123)1.96422055
110Morphological abnormality of the pyramidal tract (HP:0002062)1.96389099
111Aplasia/Hypoplasia of the lens (HP:0008063)1.95442118
112Optic disc pallor (HP:0000543)1.94533630
113Leukodystrophy (HP:0002415)1.94467650
114Bradykinesia (HP:0002067)1.94097007
115Amblyopia (HP:0000646)1.92760543
116Akinesia (HP:0002304)1.92275421
117Widely spaced teeth (HP:0000687)1.91821203
118Increased CSF lactate (HP:0002490)1.91389967
119Neuronal loss in central nervous system (HP:0002529)1.90845400
120Peripheral hypomyelination (HP:0007182)1.90559706
121Abnormality of glycolysis (HP:0004366)1.90458855
122Increased serum pyruvate (HP:0003542)1.90458855
123Insidious onset (HP:0003587)1.88640464
124Termporal pattern (HP:0011008)1.88640464
125Delayed gross motor development (HP:0002194)1.87411707
126Supranuclear gaze palsy (HP:0000605)1.86904040
127Depression (HP:0000716)1.86027955
128Generalized hypotonia (HP:0001290)1.85980133
129Volvulus (HP:0002580)1.85494132
130Limb dystonia (HP:0002451)1.83651389
131X-linked dominant inheritance (HP:0001423)1.80227966
132Esotropia (HP:0000565)1.79727558
133Mutism (HP:0002300)1.78980923
134Gastroesophageal reflux (HP:0002020)1.78205489
135Postural instability (HP:0002172)1.77774902
136Cutaneous syndactyly (HP:0012725)1.77592932
137Cortical visual impairment (HP:0100704)1.77531023
138Shawl scrotum (HP:0000049)1.77333987
139Hammertoe (HP:0001765)1.76788360
140Abnormality of the 4th metacarpal (HP:0010012)1.74944950
141Renal hypoplasia (HP:0000089)1.74058473
142Short tibia (HP:0005736)1.73660104
143Neoplasm of the heart (HP:0100544)1.73586835
144Inappropriate behavior (HP:0000719)1.73521478
145Aqueductal stenosis (HP:0002410)1.72991641
146Ulnar claw (HP:0001178)1.72887168
147Oligodactyly (hands) (HP:0001180)1.71043496
148Neoplasm of the oral cavity (HP:0100649)1.70403101
149Papillary thyroid carcinoma (HP:0002895)1.70237194
150Tented upper lip vermilion (HP:0010804)1.69153450
151Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68633171
152Intellectual disability, severe (HP:0010864)1.68316916
153Impaired vibratory sensation (HP:0002495)1.68124624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.24039965
2NTRK34.37752119
3MAP2K73.84825793
4ERBB43.43290033
5MAP3K43.43015558
6AKT33.25203791
7MAP3K123.00637724
8TSSK62.48129469
9PLK22.35833120
10PRPF4B2.26573188
11MARK12.21697708
12MAP2K42.20940816
13PDK42.10945920
14PDK32.10945920
15DYRK22.02530290
16SGK21.88413330
17MINK11.82257464
18EPHA31.78828166
19NTRK21.71398767
20GRK51.70596377
21CDK81.68648860
22TNIK1.68144497
23EPHA41.62599427
24EPHB21.54027414
25SGK4941.53439403
26SGK2231.53439403
27MUSK1.53271454
28PDK21.40019240
29TYRO31.33928737
30SIK31.33041036
31MAP4K21.29906264
32PRKCE1.26083607
33SGK31.25830672
34PNCK1.22813041
35DAPK11.22692833
36PRKCG1.21885809
37NME11.18522530
38YES11.17364357
39CDK51.16038725
40CAMK1G1.06420302
41CAMK2A1.00219934
42PKN10.99818208
43MAP3K90.99211415
44MAPK130.98341035
45CSNK1A1L0.95563946
46CSNK1G30.94480549
47FES0.94126558
48DYRK1A0.90651305
49CAMK1D0.90482909
50PRKD30.89821913
51CAMKK20.88901287
52TAOK10.88170205
53PAK30.87507456
54TRIM280.82833536
55PAK60.81054918
56PTK2B0.78479151
57CSNK1G10.78460716
58MYLK0.77773342
59CCNB10.72739478
60NTRK10.70814246
61MAPK150.70534136
62DYRK30.69223454
63CAMK2B0.68732179
64BCR0.67331983
65PRKCH0.66553260
66CAMKK10.64811759
67SIK20.64121100
68SGK10.62706628
69BRAF0.62658780
70WNK30.62316755
71CAMK10.61501727
72ERBB20.60054528
73DAPK20.59964681
74ADRBK10.59447118
75STK160.57859052
76BMPR1B0.57663156
77LATS20.57318428
78STK110.56098517
79DYRK1B0.55368431
80ADRBK20.55026837
81ROCK20.51510446
82BMPR20.50430786
83PHKG20.50303527
84PHKG10.50303527
85GRK60.49183870
86MATK0.49031943
87FGFR20.48646646
88CAMK40.48315705
89CAMK2D0.47758418
90CSNK1D0.47688977
91MAP3K60.47210631
92PRKACA0.45783159
93OXSR10.45654165
94CDK180.45337144
95NEK60.45149775
96PRKCB0.44743607
97CAMK2G0.44202497
98PLK30.43217369
99CDK190.42876179
100BRD40.41472350
101RIPK40.41411009
102WNK10.41298082
103CDK140.41109919
104UHMK10.38741503
105KSR10.38308968
106FGR0.38067963
107CDK150.37952476
108RPS6KA30.37801711
109FER0.37582511
110RET0.37346203
111PRKCZ0.36798248
112RPS6KB10.36272845
113MKNK20.35621114
114PINK10.32884718
115MAPK100.31095713
116CSNK1E0.31073340
117ERBB30.31056719
118STK380.30628034
119CDK30.30212023
120GSK3B0.30180161
121MARK20.29579656
122CSNK1G20.29147690
123PRKG10.28632351
124MAPK40.28395048
125CDK11A0.28225691
126MAPK90.27974805
127ROCK10.27319682
128PRKDC0.26601461
129MAPK80.26159527
130PRKACG0.25195835
131CSNK1A10.25065700
132SRC0.24978941
133PRKACB0.24873012
134FYN0.23411727
135PDGFRA0.22458700
136DDR20.22264834

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.98788054
2Synaptic vesicle cycle_Homo sapiens_hsa047214.12388046
3Nicotine addiction_Homo sapiens_hsa050334.06515978
4Collecting duct acid secretion_Homo sapiens_hsa049664.02359342
5GABAergic synapse_Homo sapiens_hsa047273.15283263
6* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52775440
7Morphine addiction_Homo sapiens_hsa050322.50628114
8Butanoate metabolism_Homo sapiens_hsa006502.44438658
9Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.38802168
10Vibrio cholerae infection_Homo sapiens_hsa051102.25858031
11Type I diabetes mellitus_Homo sapiens_hsa049402.21397564
12Oxidative phosphorylation_Homo sapiens_hsa001902.16958841
13Olfactory transduction_Homo sapiens_hsa047402.05907453
14Circadian entrainment_Homo sapiens_hsa047131.91142900
15Taste transduction_Homo sapiens_hsa047421.83574704
16Glutamatergic synapse_Homo sapiens_hsa047241.83170679
17Serotonergic synapse_Homo sapiens_hsa047261.79644754
18Dopaminergic synapse_Homo sapiens_hsa047281.76438673
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73599859
20Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.71518610
21Long-term potentiation_Homo sapiens_hsa047201.70849654
22Long-term depression_Homo sapiens_hsa047301.70111888
23Cholinergic synapse_Homo sapiens_hsa047251.44369821
24Amphetamine addiction_Homo sapiens_hsa050311.43946998
25* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40346240
26Rheumatoid arthritis_Homo sapiens_hsa053231.35626669
27Calcium signaling pathway_Homo sapiens_hsa040201.31110363
28Dorso-ventral axis formation_Homo sapiens_hsa043201.28609932
29Insulin secretion_Homo sapiens_hsa049111.26309166
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25814716
31Parkinsons disease_Homo sapiens_hsa050121.21782691
32Salivary secretion_Homo sapiens_hsa049701.21163731
33beta-Alanine metabolism_Homo sapiens_hsa004101.16457746
34Alzheimers disease_Homo sapiens_hsa050101.13352776
35Phagosome_Homo sapiens_hsa041451.12088274
36Gastric acid secretion_Homo sapiens_hsa049711.06976913
37Cardiac muscle contraction_Homo sapiens_hsa042601.03356030
38Colorectal cancer_Homo sapiens_hsa052101.02376920
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99867430
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99635625
41Renin secretion_Homo sapiens_hsa049240.97555711
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97480056
43Cocaine addiction_Homo sapiens_hsa050300.95079535
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94252276
45Neurotrophin signaling pathway_Homo sapiens_hsa047220.93634844
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93408255
47Endometrial cancer_Homo sapiens_hsa052130.92822641
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92674087
49Hippo signaling pathway_Homo sapiens_hsa043900.91799194
50Oxytocin signaling pathway_Homo sapiens_hsa049210.90897149
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89903830
52Hedgehog signaling pathway_Homo sapiens_hsa043400.88683817
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83142173
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82111411
55ErbB signaling pathway_Homo sapiens_hsa040120.82039005
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82034229
57Basal cell carcinoma_Homo sapiens_hsa052170.81053372
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78468837
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.77830658
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77706197
61Huntingtons disease_Homo sapiens_hsa050160.77678614
62Steroid biosynthesis_Homo sapiens_hsa001000.75763656
63Phototransduction_Homo sapiens_hsa047440.73619099
64Axon guidance_Homo sapiens_hsa043600.72372433
65Pyruvate metabolism_Homo sapiens_hsa006200.72303460
66Wnt signaling pathway_Homo sapiens_hsa043100.70459923
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70335586
68Glioma_Homo sapiens_hsa052140.66637207
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64879135
70Renal cell carcinoma_Homo sapiens_hsa052110.64648024
71Dilated cardiomyopathy_Homo sapiens_hsa054140.64426537
72Prolactin signaling pathway_Homo sapiens_hsa049170.62540977
73cAMP signaling pathway_Homo sapiens_hsa040240.62354171
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61737681
75Type II diabetes mellitus_Homo sapiens_hsa049300.61494473
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61149644
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60377295
78Gap junction_Homo sapiens_hsa045400.59916671
79Fatty acid elongation_Homo sapiens_hsa000620.58420091
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58001872
81Melanoma_Homo sapiens_hsa052180.57013590
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52650725
83AMPK signaling pathway_Homo sapiens_hsa041520.52065075
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.51566620
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51197230
86Estrogen signaling pathway_Homo sapiens_hsa049150.51078823
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49810177
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49401691
89GnRH signaling pathway_Homo sapiens_hsa049120.48322656
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48070944
91Tight junction_Homo sapiens_hsa045300.46402254
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44371919
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.43710638
94Ras signaling pathway_Homo sapiens_hsa040140.42588502
95Adherens junction_Homo sapiens_hsa045200.42242868
96mTOR signaling pathway_Homo sapiens_hsa041500.42196489
97Notch signaling pathway_Homo sapiens_hsa043300.41775328
98Ovarian steroidogenesis_Homo sapiens_hsa049130.41506793
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40847984
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40755047
101Alcoholism_Homo sapiens_hsa050340.40106634
102Melanogenesis_Homo sapiens_hsa049160.40090902
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39514723
104MAPK signaling pathway_Homo sapiens_hsa040100.39512664
105Prion diseases_Homo sapiens_hsa050200.39303854
106Circadian rhythm_Homo sapiens_hsa047100.39185274
107Glucagon signaling pathway_Homo sapiens_hsa049220.34857875
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.33722067
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33326868
110Vitamin B6 metabolism_Homo sapiens_hsa007500.33093032
111MicroRNAs in cancer_Homo sapiens_hsa052060.32883088
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32785006
113Oocyte meiosis_Homo sapiens_hsa041140.26684068
114* Rap1 signaling pathway_Homo sapiens_hsa040150.22561652
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.18832983
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18762583
117Choline metabolism in cancer_Homo sapiens_hsa052310.16744380
118Pancreatic secretion_Homo sapiens_hsa049720.15681039
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15175800
120Carbon metabolism_Homo sapiens_hsa012000.15123410
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13806211
122Propanoate metabolism_Homo sapiens_hsa006400.13394312
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13235510
124Thyroid hormone synthesis_Homo sapiens_hsa049180.12771764
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12301223
126Insulin signaling pathway_Homo sapiens_hsa049100.12162652
127Regulation of autophagy_Homo sapiens_hsa041400.12090654
128Inositol phosphate metabolism_Homo sapiens_hsa005620.10385703
129Autoimmune thyroid disease_Homo sapiens_hsa053200.09368764

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