CNRIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the C-terminal tail of cannabinoid receptor 1. Two transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to synapse (GO:0035418)5.99374618
2neuron cell-cell adhesion (GO:0007158)5.76781879
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.63518142
4presynaptic membrane assembly (GO:0097105)5.51731610
5vocalization behavior (GO:0071625)5.37406377
6postsynaptic membrane organization (GO:0001941)5.35484030
7synaptic vesicle exocytosis (GO:0016079)5.28476380
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.25345752
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99989983
10presynaptic membrane organization (GO:0097090)4.95357092
11neurotransmitter-gated ion channel clustering (GO:0072578)4.80373443
12regulation of glutamate receptor signaling pathway (GO:1900449)4.73667314
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69194134
14glutamate receptor signaling pathway (GO:0007215)4.49698022
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.46548854
16regulation of synaptic vesicle exocytosis (GO:2000300)4.39874454
17glutamate secretion (GO:0014047)4.33000629
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.31101211
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.30184560
20cellular potassium ion homeostasis (GO:0030007)4.20317113
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.18096715
22synaptic transmission, glutamatergic (GO:0035249)4.15011162
23neuronal action potential propagation (GO:0019227)4.14851609
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.12238318
25positive regulation of synapse maturation (GO:0090129)4.10085438
26neuron recognition (GO:0008038)4.02533171
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01670223
28neuron-neuron synaptic transmission (GO:0007270)3.98143991
29positive regulation of neurotransmitter secretion (GO:0001956)3.94322459
30synaptic vesicle maturation (GO:0016188)3.92372924
31positive regulation of membrane potential (GO:0045838)3.89780484
32regulation of synaptic vesicle transport (GO:1902803)3.87708864
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.85984207
34establishment of mitochondrion localization (GO:0051654)3.81418936
35positive regulation of synapse assembly (GO:0051965)3.79788706
36sodium ion export (GO:0071436)3.70631406
37regulation of postsynaptic membrane potential (GO:0060078)3.69492361
38exploration behavior (GO:0035640)3.66023353
39startle response (GO:0001964)3.60528292
40L-amino acid import (GO:0043092)3.56043091
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.55807917
42short-term memory (GO:0007614)3.55255590
43axonal fasciculation (GO:0007413)3.54556467
44pyrimidine nucleobase catabolic process (GO:0006208)3.54158748
45regulation of synapse maturation (GO:0090128)3.53158469
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52025058
47locomotory exploration behavior (GO:0035641)3.50565710
48positive regulation of neurotransmitter transport (GO:0051590)3.49729958
49potassium ion homeostasis (GO:0055075)3.48366100
50behavioral fear response (GO:0001662)3.44788888
51behavioral defense response (GO:0002209)3.44788888
52response to histamine (GO:0034776)3.43958810
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40997006
54neurotransmitter secretion (GO:0007269)3.40776798
55regulation of neuronal synaptic plasticity (GO:0048168)3.40359274
56synapse assembly (GO:0007416)3.35898851
57amino acid import (GO:0043090)3.34685177
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.34528997
59regulation of neurotransmitter secretion (GO:0046928)3.34324868
60positive regulation of dendritic spine development (GO:0060999)3.32214415
61mechanosensory behavior (GO:0007638)3.30463060
62regulation of neurotransmitter levels (GO:0001505)3.28340571
63fear response (GO:0042596)3.28304416
64regulation of respiratory system process (GO:0044065)3.28148822
65long-term memory (GO:0007616)3.27593454
66regulation of synapse assembly (GO:0051963)3.25325448
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23892079
68synaptic vesicle endocytosis (GO:0048488)3.22530202
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22260770
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.21753371
71dendritic spine morphogenesis (GO:0060997)3.21729776
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21457020
73regulation of voltage-gated calcium channel activity (GO:1901385)3.20413451
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19580121
75layer formation in cerebral cortex (GO:0021819)3.19062968
76neuronal ion channel clustering (GO:0045161)3.17764769
77membrane depolarization during action potential (GO:0086010)3.15441425
78long-term synaptic potentiation (GO:0060291)3.15238249
79auditory behavior (GO:0031223)3.14928927
80central nervous system projection neuron axonogenesis (GO:0021952)3.14104426
81transmission of nerve impulse (GO:0019226)3.12648240
82membrane depolarization (GO:0051899)3.09965512
83regulation of synapse structural plasticity (GO:0051823)3.07213777
84regulation of synaptic transmission, GABAergic (GO:0032228)3.05516799
85regulation of synaptic plasticity (GO:0048167)3.04758187
86learning (GO:0007612)3.01843224
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01825484
88protein localization to cilium (GO:0061512)3.01370095
89regulation of dendritic spine development (GO:0060998)3.01311221
90dendritic spine organization (GO:0097061)3.00377474
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99255823
92regulation of neurotransmitter transport (GO:0051588)2.98851656
93regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96239129
94regulation of glutamate secretion (GO:0014048)2.96183520
95nucleobase catabolic process (GO:0046113)2.95966353
96regulation of synapse organization (GO:0050807)2.95477000
97neurotransmitter transport (GO:0006836)2.94896939
98behavioral response to cocaine (GO:0048148)2.94677848
99acidic amino acid transport (GO:0015800)2.94510018
100righting reflex (GO:0060013)2.93883520
101innervation (GO:0060384)2.93364090
102cerebellar granule cell differentiation (GO:0021707)2.93120519
103response to auditory stimulus (GO:0010996)2.92735115
104regulation of dendritic spine morphogenesis (GO:0061001)2.92104432
105proline transport (GO:0015824)2.91578680
106mitochondrion transport along microtubule (GO:0047497)2.90789315
107establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.90789315
108dendrite development (GO:0016358)2.89921112
109adult walking behavior (GO:0007628)2.85559468
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85181119
111cell communication by electrical coupling (GO:0010644)2.84965910
112regulation of respiratory gaseous exchange (GO:0043576)2.84786927
113neuromuscular synaptic transmission (GO:0007274)2.84359329
114synaptic transmission (GO:0007268)2.83385439
115glycosphingolipid biosynthetic process (GO:0006688)2.83380976
116establishment of synaptic vesicle localization (GO:0097480)2.82810851
117synaptic vesicle transport (GO:0048489)2.82810851
118central nervous system neuron axonogenesis (GO:0021955)2.81931721
119detection of calcium ion (GO:0005513)2.81491155
120cerebral cortex radially oriented cell migration (GO:0021799)2.81431581
121regulation of vesicle fusion (GO:0031338)2.80074977
122cell migration in hindbrain (GO:0021535)2.79613081
123gamma-aminobutyric acid transport (GO:0015812)2.78302666
124neurofilament cytoskeleton organization (GO:0060052)2.78060353
125regulation of protein kinase A signaling (GO:0010738)2.77567391
126regulation of synaptic transmission (GO:0050804)2.77333748
127C4-dicarboxylate transport (GO:0015740)2.76952296
128cochlea development (GO:0090102)2.75629724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.48038868
2GBX2_23144817_ChIP-Seq_PC3_Human4.44463121
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.46179618
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.28218073
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06283556
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.96499156
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.89351558
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.81402468
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78115986
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78115986
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.75805609
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72294208
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66917703
14TAF15_26573619_Chip-Seq_HEK293_Human2.47712185
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.44548909
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33704128
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33111476
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.31571813
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26833400
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.20291161
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18557801
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17271605
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15936525
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15260976
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14066020
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.08041626
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.04873370
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01869009
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.00669866
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95783218
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93687721
32AR_21572438_ChIP-Seq_LNCaP_Human1.93225344
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91640295
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82651217
35DROSHA_22980978_ChIP-Seq_HELA_Human1.75060582
36P300_19829295_ChIP-Seq_ESCs_Human1.74663004
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.73134853
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.72409738
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72328577
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70964179
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70742098
42IGF1R_20145208_ChIP-Seq_DFB_Human1.67818997
43* RNF2_27304074_Chip-Seq_NSC_Mouse1.63194239
44FUS_26573619_Chip-Seq_HEK293_Human1.61685255
45SMAD4_21799915_ChIP-Seq_A2780_Human1.61493380
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58101450
47ZNF274_21170338_ChIP-Seq_K562_Hela1.56807357
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47955336
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43770825
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.41602652
51VDR_22108803_ChIP-Seq_LS180_Human1.39526264
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38585482
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35661900
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34948235
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.33862541
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33533627
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33211476
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.32166810
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.28729640
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27999572
61AR_25329375_ChIP-Seq_VCAP_Human1.27367339
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26834506
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.26132973
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24842558
65ER_23166858_ChIP-Seq_MCF-7_Human1.22919713
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22637195
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21874914
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21427923
69* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20649672
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20408356
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19012073
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16468004
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15822476
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.14528289
75JUN_21703547_ChIP-Seq_K562_Human1.11399541
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.11022079
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10290687
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.08946292
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.05860107
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.05815802
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.05758868
82RUNX2_22187159_ChIP-Seq_PCA_Human1.05041903
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04846763
84STAT3_23295773_ChIP-Seq_U87_Human1.04774526
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03923420
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03364480
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02670570
88* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02468486
89* TET1_21490601_ChIP-Seq_MESCs_Mouse1.02068532
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00977296
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00731037
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99869090
93* TCF4_23295773_ChIP-Seq_U87_Human0.99658606
94* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98925234
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.98386691
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98380933
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97376794
98OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96724394
99EWS_26573619_Chip-Seq_HEK293_Human0.96681604
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96571580
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96571580
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93303471
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92882946
104P53_22387025_ChIP-Seq_ESCs_Mouse0.92146300
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91678410
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.90900737
107E2F1_18555785_Chip-Seq_ESCs_Mouse0.90807903
108* TAL1_26923725_Chip-Seq_HPCs_Mouse0.90539357
109AR_19668381_ChIP-Seq_PC3_Human0.90527214
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90296296
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87986077
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.87725219
113* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86970202
114TP53_18474530_ChIP-ChIP_U2OS_Human0.86857362
115KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86442160
116* KDM2B_26808549_Chip-Seq_REH_Human0.85522796
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85227107
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84601116
119SOX9_26525672_Chip-Seq_HEART_Mouse0.84427319
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84254743
121CBP_20019798_ChIP-Seq_JUKART_Human0.84254743
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83989666
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81548870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.66274177
2MP0004859_abnormal_synaptic_plasticity4.86661983
3MP0003635_abnormal_synaptic_transmissio3.59512891
4MP0001968_abnormal_touch/_nociception3.41340561
5MP0009745_abnormal_behavioral_response3.13237963
6MP0004270_analgesia3.04325249
7MP0002063_abnormal_learning/memory/cond2.95245363
8MP0002064_seizures2.88568501
9MP0002736_abnormal_nociception_after2.85394969
10MP0009046_muscle_twitch2.73004239
11MP0002572_abnormal_emotion/affect_behav2.68879360
12MP0002734_abnormal_mechanical_nocicepti2.56650898
13MP0006276_abnormal_autonomic_nervous2.49546210
14MP0001188_hyperpigmentation2.46029890
15MP0002735_abnormal_chemical_nociception2.42891860
16MP0001486_abnormal_startle_reflex2.42224822
17MP0002272_abnormal_nervous_system2.39356998
18MP0005423_abnormal_somatic_nervous2.34027967
19MP0000778_abnormal_nervous_system2.30038202
20MP0002067_abnormal_sensory_capabilities2.20547211
21MP0002184_abnormal_innervation2.02271020
22MP0001440_abnormal_grooming_behavior1.95347956
23MP0001970_abnormal_pain_threshold1.94795089
24MP0002733_abnormal_thermal_nociception1.93432360
25MP0002557_abnormal_social/conspecific_i1.88503060
26MP0001501_abnormal_sleep_pattern1.81871230
27MP0001984_abnormal_olfaction1.81673954
28MP0004147_increased_porphyrin_level1.80482498
29MP0001905_abnormal_dopamine_level1.77413944
30MP0008569_lethality_at_weaning1.67032380
31MP0004142_abnormal_muscle_tone1.66769528
32MP0006292_abnormal_olfactory_placode1.63490258
33MP0002822_catalepsy1.62310431
34MP0005386_behavior/neurological_phenoty1.56753359
35MP0004924_abnormal_behavior1.56753359
36MP0003879_abnormal_hair_cell1.56166132
37MP0003122_maternal_imprinting1.53693271
38MP0001529_abnormal_vocalization1.51456900
39MP0005646_abnormal_pituitary_gland1.47787526
40MP0005551_abnormal_eye_electrophysiolog1.46886179
41MP0002882_abnormal_neuron_morphology1.46033915
42MP0005409_darkened_coat_color1.45642451
43MP0005645_abnormal_hypothalamus_physiol1.44642424
44MP0004811_abnormal_neuron_physiology1.43936169
45MP0000955_abnormal_spinal_cord1.42123343
46MP0010386_abnormal_urinary_bladder1.36653681
47MP0009379_abnormal_foot_pigmentation1.35008559
48MP0002638_abnormal_pupillary_reflex1.34436315
49MP0000631_abnormal_neuroendocrine_gland1.31641475
50MP0002066_abnormal_motor_capabilities/c1.30252824
51MP0000751_myopathy1.28763128
52MP0003690_abnormal_glial_cell1.28341250
53MP0003787_abnormal_imprinting1.25553105
54MP0005394_taste/olfaction_phenotype1.25419004
55MP0005499_abnormal_olfactory_system1.25419004
56MP0000920_abnormal_myelination1.24241279
57MP0001502_abnormal_circadian_rhythm1.24012504
58MP0002876_abnormal_thyroid_physiology1.21965787
59MP0009780_abnormal_chondrocyte_physiolo1.17032424
60MP0002152_abnormal_brain_morphology1.15134522
61MP0005503_abnormal_tendon_morphology1.13970308
62MP0002752_abnormal_somatic_nervous1.12335475
63MP0003136_yellow_coat_color1.10074564
64MP0001963_abnormal_hearing_physiology1.06744374
65MP0005167_abnormal_blood-brain_barrier1.06144634
66MP0000604_amyloidosis1.04854737
67MP0002102_abnormal_ear_morphology1.04417272
68MP0008438_abnormal_cutaneous_collagen1.04057128
69MP0005171_absent_coat_pigmentation1.04045417
70MP0002751_abnormal_autonomic_nervous1.03098217
71MP0004145_abnormal_muscle_electrophysio1.03072246
72MP0008877_abnormal_DNA_methylation1.02997320
73MP0000015_abnormal_ear_pigmentation1.02892945
74MP0004742_abnormal_vestibular_system1.02496428
75MP0004858_abnormal_nervous_system1.02388327
76MP0008789_abnormal_olfactory_epithelium0.98978661
77MP0003329_amyloid_beta_deposits0.98720722
78MP0003121_genomic_imprinting0.98663249
79MP0003633_abnormal_nervous_system0.96642835
80MP0000026_abnormal_inner_ear0.96439675
81MP0002229_neurodegeneration0.95499811
82MP0010368_abnormal_lymphatic_system0.93847992
83MP0003656_abnormal_erythrocyte_physiolo0.91481664
84MP0003938_abnormal_ear_development0.89568204
85MP0002090_abnormal_vision0.87326027
86MP0002069_abnormal_eating/drinking_beha0.83703691
87MP0003632_abnormal_nervous_system0.81689872
88MP0003631_nervous_system_phenotype0.81656748
89MP0000681_abnormal_thyroid_gland0.81563198
90MP0001542_abnormal_bone_strength0.79355206
91MP0001664_abnormal_digestion0.78892667
92MP0005623_abnormal_meninges_morphology0.78633646
93MP0001986_abnormal_taste_sensitivity0.78561777
94MP0004885_abnormal_endolymph0.76484688
95MP0002909_abnormal_adrenal_gland0.76260171
96MP0000049_abnormal_middle_ear0.76083944
97MP0002653_abnormal_ependyma_morphology0.76054184
98MP0002295_abnormal_pulmonary_circulatio0.75118647
99MP0006072_abnormal_retinal_apoptosis0.75006735
100MP0001177_atelectasis0.74995726
101MP0002837_dystrophic_cardiac_calcinosis0.72267318
102MP0001485_abnormal_pinna_reflex0.71640460
103MP0003861_abnormal_nervous_system0.68912058
104MP0005253_abnormal_eye_physiology0.68501578
105MP0004085_abnormal_heartbeat0.66923458
106MP0003385_abnormal_body_wall0.64998722
107MP0003279_aneurysm0.64378022
108MP0005595_abnormal_vascular_smooth0.62586137
109MP0001299_abnormal_eye_distance/0.61861082
110MP0005535_abnormal_body_temperature0.61311925
111MP0005195_abnormal_posterior_eye0.60943060
112MP0003634_abnormal_glial_cell0.60621170
113MP0005187_abnormal_penis_morphology0.60519146
114MP0001545_abnormal_hematopoietic_system0.60139002
115MP0005397_hematopoietic_system_phenotyp0.60139002
116MP0008874_decreased_physiological_sensi0.58504613
117MP0003137_abnormal_impulse_conducting0.57347199
118MP0005174_abnormal_tail_pigmentation0.56876410
119MP0004215_abnormal_myocardial_fiber0.56295006
120MP0001958_emphysema0.54795173
121MP0008872_abnormal_physiological_respon0.54682044
122MP0001943_abnormal_respiration0.54280217
123MP0010770_preweaning_lethality0.54113240
124MP0002082_postnatal_lethality0.54113240
125MP0010769_abnormal_survival0.53105870
126MP0000639_abnormal_adrenal_gland0.49192468

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.20340744
2Epileptic encephalopathy (HP:0200134)5.09773325
3Myokymia (HP:0002411)4.73436978
4Focal seizures (HP:0007359)4.63276462
5Febrile seizures (HP:0002373)4.63111843
6Atonic seizures (HP:0010819)4.58497942
7Broad-based gait (HP:0002136)4.33627779
8Hyperventilation (HP:0002883)4.31412274
9Visual hallucinations (HP:0002367)4.31154082
10Progressive cerebellar ataxia (HP:0002073)3.78731079
11Absence seizures (HP:0002121)3.76052000
12Dialeptic seizures (HP:0011146)3.53791872
13Neurofibrillary tangles (HP:0002185)3.49897525
14Torticollis (HP:0000473)3.24952393
15Abnormal hair whorl (HP:0010721)3.24825053
16Gait imbalance (HP:0002141)3.13254759
17Cerebral hypomyelination (HP:0006808)3.10799672
18Spastic gait (HP:0002064)2.98201962
19Gaze-evoked nystagmus (HP:0000640)2.96844984
20Acute necrotizing encephalopathy (HP:0006965)2.94507214
21Generalized tonic-clonic seizures (HP:0002069)2.93640817
22Polyphagia (HP:0002591)2.90589306
23Amblyopia (HP:0000646)2.90432904
24Focal dystonia (HP:0004373)2.88239674
25Excessive salivation (HP:0003781)2.84824608
26Drooling (HP:0002307)2.84824608
27Absent speech (HP:0001344)2.83390313
28Medial flaring of the eyebrow (HP:0010747)2.81733722
29Limb dystonia (HP:0002451)2.77996097
30Mitochondrial inheritance (HP:0001427)2.74510986
31Inability to walk (HP:0002540)2.73680040
32Intention tremor (HP:0002080)2.70206415
33Craniofacial dystonia (HP:0012179)2.70017865
34Cerebral inclusion bodies (HP:0100314)2.68940448
35Optic disc pallor (HP:0000543)2.68062615
36Mutism (HP:0002300)2.67720713
37Abnormal mitochondria in muscle tissue (HP:0008316)2.66745293
38Progressive inability to walk (HP:0002505)2.65329232
39Congenital primary aphakia (HP:0007707)2.62742584
40Protruding tongue (HP:0010808)2.62325505
41Progressive macrocephaly (HP:0004481)2.60684571
42Postural instability (HP:0002172)2.58615014
43Anxiety (HP:0000739)2.55114652
44Abnormal eating behavior (HP:0100738)2.53882794
45Depression (HP:0000716)2.53018800
46Hypothermia (HP:0002045)2.51864871
47Nephrogenic diabetes insipidus (HP:0009806)2.51498905
48Agitation (HP:0000713)2.51188150
49Poor eye contact (HP:0000817)2.49093619
50Lower limb muscle weakness (HP:0007340)2.48436906
51Bradykinesia (HP:0002067)2.46622413
52Retinal dysplasia (HP:0007973)2.46233021
53Truncal ataxia (HP:0002078)2.42076608
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.40875167
55Hepatocellular necrosis (HP:0001404)2.38041994
56Apathy (HP:0000741)2.37486669
57Poor suck (HP:0002033)2.36719314
58Sleep apnea (HP:0010535)2.34184634
59Epileptiform EEG discharges (HP:0011182)2.32504024
60Abnormality of the lower motor neuron (HP:0002366)2.31177529
61CNS hypomyelination (HP:0003429)2.30171855
62Urinary urgency (HP:0000012)2.30020471
63Diminished motivation (HP:0000745)2.29819042
64Abnormality of the corticospinal tract (HP:0002492)2.28941831
65Neuronal loss in central nervous system (HP:0002529)2.27799467
66Esotropia (HP:0000565)2.25429305
67Narrow nasal bridge (HP:0000446)2.23322223
68Scanning speech (HP:0002168)2.22766905
69Increased hepatocellular lipid droplets (HP:0006565)2.17754778
70Spastic tetraplegia (HP:0002510)2.17423793
71Renal Fanconi syndrome (HP:0001994)2.15706880
72Increased CSF lactate (HP:0002490)2.15185800
73Abnormality of binocular vision (HP:0011514)2.13101463
74Diplopia (HP:0000651)2.13101463
75Supranuclear gaze palsy (HP:0000605)2.12836425
76Dysmetria (HP:0001310)2.11646847
77Hemiparesis (HP:0001269)2.11160989
78Thyroid-stimulating hormone excess (HP:0002925)2.09815274
79Unsteady gait (HP:0002317)2.09377784
80Genetic anticipation (HP:0003743)2.08363293
81Dysdiadochokinesis (HP:0002075)2.06985634
82Status epilepticus (HP:0002133)2.06422648
83Blue irides (HP:0000635)2.05752201
84Specific learning disability (HP:0001328)2.05670320
85Delusions (HP:0000746)2.04125658
86Morphological abnormality of the pyramidal tract (HP:0002062)2.03897107
87Obstructive sleep apnea (HP:0002870)2.03285759
88Stereotypic behavior (HP:0000733)2.02013180
89Action tremor (HP:0002345)2.02008212
90EEG with generalized epileptiform discharges (HP:0011198)2.01493551
91Impaired social interactions (HP:0000735)2.01258751
92Abnormal social behavior (HP:0012433)2.01258751
93Fetal akinesia sequence (HP:0001989)2.01029747
94Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.99926459
95Amyotrophic lateral sclerosis (HP:0007354)1.99127026
96Acute encephalopathy (HP:0006846)1.98742131
97Myotonia (HP:0002486)1.95908442
98Genital tract atresia (HP:0001827)1.95485199
99Aplasia/Hypoplasia of the lens (HP:0008063)1.93236882
100Vaginal atresia (HP:0000148)1.92929690
101Rapidly progressive (HP:0003678)1.92261836
102Generalized hypotonia (HP:0001290)1.91912708
103Hyperthyroidism (HP:0000836)1.87804390
104Nonprogressive disorder (HP:0003680)1.87794805
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87287202
106Decreased circulating renin level (HP:0003351)1.86171043
107Rigidity (HP:0002063)1.85462964
108Psychosis (HP:0000709)1.84641368
109Poor coordination (HP:0002370)1.84445653
110Abnormality of salivation (HP:0100755)1.84260754
111Impaired vibration sensation in the lower limbs (HP:0002166)1.83075834
112Emotional lability (HP:0000712)1.82895476
113Tetraplegia (HP:0002445)1.82850526
114Generalized myoclonic seizures (HP:0002123)1.82445165
115Hypoventilation (HP:0002791)1.82379718
116Peripheral hypomyelination (HP:0007182)1.81960271
117Annular pancreas (HP:0001734)1.81426192
118Urinary bladder sphincter dysfunction (HP:0002839)1.81143361
119Hemiplegia (HP:0002301)1.80595064
120Absent/shortened dynein arms (HP:0200106)1.80520930
121Dynein arm defect of respiratory motile cilia (HP:0012255)1.80520930
122Restlessness (HP:0000711)1.80366602
123Ankle clonus (HP:0011448)1.80229051
124Lissencephaly (HP:0001339)1.80056697
125Hypsarrhythmia (HP:0002521)1.79718000
126Wrist flexion contracture (HP:0001239)1.79254914
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.78447482
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78447482
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77962669
130Severe visual impairment (HP:0001141)1.77819647
131Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76515969
132Hypoplasia of the brainstem (HP:0002365)1.76515969
133Fair hair (HP:0002286)1.76464524
134Clonus (HP:0002169)1.76057564
135Incomplete penetrance (HP:0003829)1.75168889
136Impaired smooth pursuit (HP:0007772)1.74599516
137Inappropriate behavior (HP:0000719)1.73847057
138Akinesia (HP:0002304)1.73776629
139Insomnia (HP:0100785)1.73415573
140Split foot (HP:0001839)1.72536340
141Abnormal EKG (HP:0003115)1.69687687
142Failure to thrive in infancy (HP:0001531)1.65188920
143Heterochromia iridis (HP:0001100)1.64727766
144Prolonged QT interval (HP:0001657)1.64697925
145Lower limb amyotrophy (HP:0007210)1.64173598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.96341790
2NTRK33.44111106
3MAP2K73.42655499
4EPHA43.35104731
5CDK193.16098288
6MARK13.14131047
7TLK12.85501926
8MAP3K122.78973913
9MAP3K42.73410631
10TNIK2.72890264
11MAP4K22.28340512
12PIM22.24296969
13MAPK132.16484891
14PRPF4B2.15003442
15PLK22.03412968
16MINK11.98155211
17DAPK21.92692579
18LIMK11.91704627
19TESK11.82417182
20PRKD31.74995742
21TIE11.73599079
22MAP3K91.71181330
23PINK11.65166865
24NTRK21.60829237
25GRK51.57307811
26DAPK11.56527942
27MAP2K41.55914843
28MKNK21.40677054
29RIPK41.40619779
30NME11.33740999
31SIK21.29106102
32FES1.20293297
33CDK51.20068103
34MAP3K111.18354843
35ARAF1.17682717
36UHMK11.15250398
37PRKCG1.10219646
38CAMK2A1.08443037
39PHKG11.07845437
40PHKG21.07845437
41PAK31.07361665
42CAMK2B1.06832226
43OXSR11.05227308
44CCNB11.03202287
45DAPK31.03064222
46MUSK1.02175398
47DYRK1A1.01716067
48PAK60.99372988
49CSNK1G10.95631801
50CAMKK20.94440326
51ADRBK20.91089446
52ABL20.91054213
53KSR10.89381651
54STK380.88236000
55DYRK20.87192895
56BCR0.86949659
57CSNK1G20.86076809
58BRAF0.84467312
59AKT30.83752082
60BMPR20.82045446
61BMPR1B0.81716578
62PTK2B0.77255955
63PNCK0.77112898
64CDK140.77009451
65FGR0.76921401
66MARK20.74996073
67CDK180.74513331
68GRK70.74081829
69PRKCE0.73720658
70STK160.71121684
71CDK150.70285696
72DDR20.70088739
73SGK2230.70083722
74SGK4940.70083722
75CAMK10.69853506
76PRKD20.69122652
77CDK11A0.66805622
78ADRBK10.65975086
79PKN10.64799426
80SIK30.64655139
81SGK20.64287037
82MAPKAPK50.63782899
83CDK80.60598510
84STK110.60322029
85BCKDK0.59647659
86MOS0.58532900
87CAMKK10.57367246
88NTRK10.55923667
89CAMK2D0.54552083
90MAPK120.52986871
91TSSK60.50529666
92MAPK40.50396211
93CDK30.49782696
94CSNK1G30.49514135
95WNK30.48627705
96PRKCH0.44908937
97CAMK2G0.44567474
98TAOK20.44403394
99TNK20.43943145
100YES10.43431411
101PAK20.43417181
102RPS6KA30.40351680
103SRPK10.40209401
104MAP3K60.39479826
105DMPK0.38622325
106MAPK100.38561587
107CAMK40.38441573
108MKNK10.37695416
109PRKCA0.37646103
110SGK10.37105532
111MYLK0.36965627
112ROCK10.35483722
113EPHB20.34577299
114GRK60.34516345
115ROCK20.33985330
116PRKCZ0.33415989
117BRSK10.32438964
118RAF10.32166812
119TYRO30.32118700
120FER0.32034253
121PRKACA0.31766693
122CSNK1A10.31127216
123TGFBR20.30698709
124ERBB30.30532561
125PRKG10.29941683
126IRAK20.28864943
127LATS20.28134788
128CSNK1A1L0.27997854
129CSNK1D0.27862297
130DYRK30.26946832

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.58793577
2Synaptic vesicle cycle_Homo sapiens_hsa047213.62684148
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.01723204
4Morphine addiction_Homo sapiens_hsa050322.79381593
5Circadian entrainment_Homo sapiens_hsa047132.72899591
6Olfactory transduction_Homo sapiens_hsa047402.69011600
7GABAergic synapse_Homo sapiens_hsa047272.66175685
8Glutamatergic synapse_Homo sapiens_hsa047242.54532200
9Collecting duct acid secretion_Homo sapiens_hsa049662.50465435
10Long-term potentiation_Homo sapiens_hsa047202.37724750
11Amphetamine addiction_Homo sapiens_hsa050312.26174190
12Oxidative phosphorylation_Homo sapiens_hsa001902.18251821
13Taste transduction_Homo sapiens_hsa047422.18127395
14Dopaminergic synapse_Homo sapiens_hsa047282.10534738
15Serotonergic synapse_Homo sapiens_hsa047261.97342220
16Salivary secretion_Homo sapiens_hsa049701.84098013
17Long-term depression_Homo sapiens_hsa047301.81318324
18Phototransduction_Homo sapiens_hsa047441.81221380
19Insulin secretion_Homo sapiens_hsa049111.78385155
20Cholinergic synapse_Homo sapiens_hsa047251.76637855
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70923542
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67143161
23Renin secretion_Homo sapiens_hsa049241.65066936
24Alzheimers disease_Homo sapiens_hsa050101.63348402
25Parkinsons disease_Homo sapiens_hsa050121.58853545
26Calcium signaling pathway_Homo sapiens_hsa040201.56314415
27Vibrio cholerae infection_Homo sapiens_hsa051101.51789283
28Cocaine addiction_Homo sapiens_hsa050301.51334532
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51178618
30Oxytocin signaling pathway_Homo sapiens_hsa049211.42739934
31Axon guidance_Homo sapiens_hsa043601.39920745
32Cardiac muscle contraction_Homo sapiens_hsa042601.33121721
33Gastric acid secretion_Homo sapiens_hsa049711.32541413
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31590040
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30796435
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23975384
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23886545
38Gap junction_Homo sapiens_hsa045401.22044642
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20910697
40Huntingtons disease_Homo sapiens_hsa050161.20089826
41GnRH signaling pathway_Homo sapiens_hsa049121.16770190
42Melanogenesis_Homo sapiens_hsa049161.13379882
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12748854
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11940522
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09339071
46Fatty acid elongation_Homo sapiens_hsa000621.05040856
47cAMP signaling pathway_Homo sapiens_hsa040241.02780170
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97811001
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92929638
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92088194
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87740083
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82427059
53ErbB signaling pathway_Homo sapiens_hsa040120.81872180
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79324533
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.78733672
56Butanoate metabolism_Homo sapiens_hsa006500.77680082
57Prion diseases_Homo sapiens_hsa050200.77080923
58Estrogen signaling pathway_Homo sapiens_hsa049150.76460894
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76374883
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75313768
61Rheumatoid arthritis_Homo sapiens_hsa053230.74017843
62Vitamin B6 metabolism_Homo sapiens_hsa007500.71064026
63Wnt signaling pathway_Homo sapiens_hsa043100.70595817
64Sulfur relay system_Homo sapiens_hsa041220.70176841
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69816689
66Glioma_Homo sapiens_hsa052140.67318394
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64205614
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63826638
69Oocyte meiosis_Homo sapiens_hsa041140.63650694
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63171319
71Alcoholism_Homo sapiens_hsa050340.61931580
72Ras signaling pathway_Homo sapiens_hsa040140.60024706
73MAPK signaling pathway_Homo sapiens_hsa040100.59600749
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55917171
75Folate biosynthesis_Homo sapiens_hsa007900.55284368
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.54657914
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54638526
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53817832
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.50863909
80Type II diabetes mellitus_Homo sapiens_hsa049300.48642225
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.48022912
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46558983
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45985051
84Phagosome_Homo sapiens_hsa041450.45095342
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43941255
86Dilated cardiomyopathy_Homo sapiens_hsa054140.43826798
87Pancreatic secretion_Homo sapiens_hsa049720.43441955
88Choline metabolism in cancer_Homo sapiens_hsa052310.42732642
89Circadian rhythm_Homo sapiens_hsa047100.41583349
90Ovarian steroidogenesis_Homo sapiens_hsa049130.39550133
91African trypanosomiasis_Homo sapiens_hsa051430.39244154
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37645996
93Rap1 signaling pathway_Homo sapiens_hsa040150.37371387
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.37362298
95Ribosome_Homo sapiens_hsa030100.35698939
96Sphingolipid metabolism_Homo sapiens_hsa006000.35063398
97Nitrogen metabolism_Homo sapiens_hsa009100.34776631
98Mineral absorption_Homo sapiens_hsa049780.31643657
99AMPK signaling pathway_Homo sapiens_hsa041520.31436676
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31431434
101Bile secretion_Homo sapiens_hsa049760.30667874
102beta-Alanine metabolism_Homo sapiens_hsa004100.30302702
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29959050
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28341881
105Thyroid hormone synthesis_Homo sapiens_hsa049180.27718660
106Regulation of autophagy_Homo sapiens_hsa041400.27318322
107Dorso-ventral axis formation_Homo sapiens_hsa043200.27143925
108Colorectal cancer_Homo sapiens_hsa052100.26616770
109Endometrial cancer_Homo sapiens_hsa052130.26548919
110VEGF signaling pathway_Homo sapiens_hsa043700.26217161
111Type I diabetes mellitus_Homo sapiens_hsa049400.25924261
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25868446
113Inositol phosphate metabolism_Homo sapiens_hsa005620.25471050
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21659405
115Melanoma_Homo sapiens_hsa052180.20695147
116Glucagon signaling pathway_Homo sapiens_hsa049220.19751682
117Protein export_Homo sapiens_hsa030600.18465549
118Hedgehog signaling pathway_Homo sapiens_hsa043400.18101766
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18088116
120Endocytosis_Homo sapiens_hsa041440.16985080
121Renal cell carcinoma_Homo sapiens_hsa052110.16296333
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14977234

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