CNST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)6.20551282
2positive regulation of granulocyte differentiation (GO:0030854)5.40074436
3regulation of platelet aggregation (GO:0090330)5.14132633
4cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.89045569
5positive regulation of gamma-delta T cell activation (GO:0046645)4.61928369
6neutrophil activation involved in immune response (GO:0002283)4.50890313
7regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.48118296
8negative regulation of potassium ion transmembrane transport (GO:1901380)4.47858396
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.34067366
10regulation of platelet activation (GO:0010543)4.31858679
11megakaryocyte development (GO:0035855)4.29015686
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.28466554
13cell communication by electrical coupling (GO:0010644)4.28007100
14plasma membrane repair (GO:0001778)4.26846443
15definitive hemopoiesis (GO:0060216)4.22071828
16cell communication involved in cardiac conduction (GO:0086065)4.20914707
17regulation of B cell receptor signaling pathway (GO:0050855)4.17910825
18sodium ion export (GO:0071436)4.17507958
19platelet aggregation (GO:0070527)4.14701713
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.13556800
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.11502604
22negative regulation of erythrocyte differentiation (GO:0045647)4.08058182
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01698026
24regulation of membrane repolarization (GO:0060306)3.91892407
25negative regulation of cytosolic calcium ion concentration (GO:0051481)3.87003153
26activation of protein kinase A activity (GO:0034199)3.84017489
27positive regulation of B cell differentiation (GO:0045579)3.82476847
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.81501103
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.78800006
30negative regulation of T-helper cell differentiation (GO:0045623)3.78230294
31negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.78230294
32B cell receptor signaling pathway (GO:0050853)3.74931913
33carnitine shuttle (GO:0006853)3.66443575
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66204880
35cardiac myofibril assembly (GO:0055003)3.64094889
36sarcomere organization (GO:0045214)3.63713222
37angiogenesis involved in wound healing (GO:0060055)3.61769020
38regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.61573856
39regulation of gamma-delta T cell differentiation (GO:0045586)3.54244526
40synaptic vesicle maturation (GO:0016188)3.54142957
41potassium ion export (GO:0071435)3.54097963
42regulation of female receptivity (GO:0045924)3.53257305
43positive regulation of potassium ion transmembrane transport (GO:1901381)3.52670967
44relaxation of cardiac muscle (GO:0055119)3.52533153
45cellular potassium ion homeostasis (GO:0030007)3.50438297
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.49329456
47cardiac muscle contraction (GO:0060048)3.48444520
48G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.48421649
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47527212
50purinergic nucleotide receptor signaling pathway (GO:0035590)3.41539426
51protein targeting to Golgi (GO:0000042)3.40806916
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.38285856
53ventricular cardiac muscle cell action potential (GO:0086005)3.32804232
54membrane depolarization during action potential (GO:0086010)3.31957216
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.31282130
56regulation of synapse structural plasticity (GO:0051823)3.31128790
57positive regulation of mast cell activation (GO:0033005)3.30815513
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.30813961
59regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28770983
60myeloid cell development (GO:0061515)3.23562257
61blood coagulation, intrinsic pathway (GO:0007597)3.19387671
62detection of calcium ion (GO:0005513)3.15982333
63potassium ion import (GO:0010107)3.13919532
64negative regulation of homotypic cell-cell adhesion (GO:0034111)3.13025784
65membrane repolarization (GO:0086009)3.12642408
66myofibril assembly (GO:0030239)3.11392224
67regulation of granulocyte differentiation (GO:0030852)3.10615856
68regulation of gamma-delta T cell activation (GO:0046643)3.09573880
69establishment of protein localization to Golgi (GO:0072600)3.09117739
70protein neddylation (GO:0045116)3.08316323
71retrograde transport, vesicle recycling within Golgi (GO:0000301)3.07804095
72regulation of heart rate by cardiac conduction (GO:0086091)3.07411844
73fatty acid transmembrane transport (GO:1902001)3.07114733
74cerebellar Purkinje cell differentiation (GO:0021702)3.05538087
75homotypic cell-cell adhesion (GO:0034109)3.04098280
76neutrophil activation (GO:0042119)3.03651664
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03464067
78negative regulation of cell killing (GO:0031342)3.03464067
79negative thymic T cell selection (GO:0045060)3.03334275
80negative T cell selection (GO:0043383)3.03322485
81regulation of ARF protein signal transduction (GO:0032012)3.03320825
82positive regulation of potassium ion transport (GO:0043268)3.02381935
83tricarboxylic acid cycle (GO:0006099)3.01841977
84striatum development (GO:0021756)3.01534870
85cardiac conduction (GO:0061337)3.00264884
86female mating behavior (GO:0060180)2.99897793
87regulation of regulatory T cell differentiation (GO:0045589)2.98252034
88membrane repolarization during action potential (GO:0086011)2.97405432
89regulation of sodium ion transmembrane transporter activity (GO:2000649)2.97245935
90interkinetic nuclear migration (GO:0022027)2.97115424
91regulation of calcium ion transmembrane transport (GO:1903169)2.96753778
92regulation of calcium ion transmembrane transporter activity (GO:1901019)2.96753778
93autophagic vacuole fusion (GO:0000046)2.96615996
94positive regulation of sodium ion transport (GO:0010765)2.95734907
95sarcoplasmic reticulum calcium ion transport (GO:0070296)2.95275166
96regulation of homotypic cell-cell adhesion (GO:0034110)2.94803735
97neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.93962917
98cardiac muscle cell action potential (GO:0086001)2.91945885
99regulation of cell communication by electrical coupling (GO:0010649)2.91735004
100regulation of B cell differentiation (GO:0045577)2.91595107
101leukocyte migration involved in inflammatory response (GO:0002523)2.91500803
102cardiac muscle cell action potential involved in contraction (GO:0086002)2.89551769
103leukocyte degranulation (GO:0043299)2.89120351
104negative regulation of neurotransmitter transport (GO:0051589)2.88471837
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.88424355
106regulation of potassium ion transmembrane transport (GO:1901379)2.87968973
107negative regulation of neurotransmitter secretion (GO:0046929)2.86385914
108positive regulation of alpha-beta T cell proliferation (GO:0046641)2.86350365
109negative regulation of potassium ion transport (GO:0043267)2.85977159
110phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.85932485
111positive T cell selection (GO:0043368)2.85856512
112negative regulation of interleukin-17 production (GO:0032700)2.84886000
113regulation of T-helper 1 cell differentiation (GO:0045625)2.84188371
114platelet activation (GO:0030168)2.83280729
115positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.82313064
116negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.81722831
117positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.81443376
118regulation of synaptic vesicle exocytosis (GO:2000300)2.81338281
119platelet formation (GO:0030220)2.80670737
120relaxation of muscle (GO:0090075)2.79927306
121regulation of cAMP-dependent protein kinase activity (GO:2000479)2.79876216
122positive thymic T cell selection (GO:0045059)2.79372256
123proline transport (GO:0015824)2.78782714
124regulation of integrin activation (GO:0033623)2.78726516
125potassium ion homeostasis (GO:0055075)2.78552015
126regulation of sodium ion transmembrane transport (GO:1902305)2.77985257
127negative regulation of norepinephrine secretion (GO:0010700)2.77481878
128synaptic vesicle exocytosis (GO:0016079)2.76594068
129vesicle transport along microtubule (GO:0047496)2.74486229
130positive regulation of macrophage differentiation (GO:0045651)2.73665753
131adenosine receptor signaling pathway (GO:0001973)2.73421845
132nerve growth factor signaling pathway (GO:0038180)2.72970030
133negative regulation of platelet activation (GO:0010544)2.72244444
134regulation of synaptic vesicle transport (GO:1902803)2.72123924
135regulation of potassium ion transmembrane transporter activity (GO:1901016)2.71558847
136striated muscle contraction (GO:0006941)2.70423431
137carnitine transmembrane transport (GO:1902603)2.69937209
138cardiac muscle cell development (GO:0055013)2.69186133
139regulation of alpha-beta T cell proliferation (GO:0046640)2.68875258
140organelle membrane fusion (GO:0090174)2.68514672
141positive regulation of sodium ion transmembrane transport (GO:1902307)2.68353550
142regulation of relaxation of muscle (GO:1901077)2.67824110
143protein targeting to plasma membrane (GO:0072661)2.67161624
144layer formation in cerebral cortex (GO:0021819)2.66318095
145regulation of cation channel activity (GO:2001257)2.65600063
146regulation of skeletal muscle contraction (GO:0014819)2.65226687
147regulation of acyl-CoA biosynthetic process (GO:0050812)2.64803452
148regulation of clathrin-mediated endocytosis (GO:2000369)2.64671780
149response to pheromone (GO:0019236)2.64089767
150actomyosin structure organization (GO:0031032)2.63361221
151regulation of erythrocyte differentiation (GO:0045646)2.62761791
152purinergic receptor signaling pathway (GO:0035587)2.62460365
153glutamate secretion (GO:0014047)2.62305014
154positive regulation of hemostasis (GO:1900048)2.61795917
155positive regulation of blood coagulation (GO:0030194)2.61795917
156response to interleukin-15 (GO:0070672)2.60855135
157myeloid cell activation involved in immune response (GO:0002275)2.60725787
158negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60294063
159mast cell activation (GO:0045576)2.59350519
160mast cell activation involved in immune response (GO:0002279)2.59264614
161mast cell degranulation (GO:0043303)2.59264614
162granulocyte activation (GO:0036230)2.59244316
163positive regulation of cation channel activity (GO:2001259)2.58800394
164endothelium development (GO:0003158)2.58735766
165negative regulation of heart contraction (GO:0045822)2.58463931
166relaxation of smooth muscle (GO:0044557)2.57819422
167locomotory exploration behavior (GO:0035641)2.57795521
168regulation of lipoprotein metabolic process (GO:0050746)2.57142272
169positive regulation of T cell cytokine production (GO:0002726)2.56856227
170lipoxygenase pathway (GO:0019372)2.56562370
171regulation of inositol phosphate biosynthetic process (GO:0010919)2.56300809
172bundle of His cell to Purkinje myocyte communication (GO:0086069)2.55866648
173cellular sodium ion homeostasis (GO:0006883)2.55799489
174regulation of mast cell activation (GO:0033003)2.55708309
175regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.54988053
176regulation of mast cell degranulation (GO:0043304)2.53759144
177antigen receptor-mediated signaling pathway (GO:0050851)2.53758042
178response to caffeine (GO:0031000)2.53576619
179cardiac cell development (GO:0055006)2.51972219
180positive regulation of ion transmembrane transporter activity (GO:0032414)2.51807816
181negative regulation of inclusion body assembly (GO:0090084)2.51370440
182regulation of sodium ion transport (GO:0002028)2.50434760
183negative regulation of T cell apoptotic process (GO:0070233)2.46955964
184regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.46257195
185regulation of the force of heart contraction (GO:0002026)2.45935355
186Arp2/3 complex-mediated actin nucleation (GO:0034314)2.45703531
187cell migration in hindbrain (GO:0021535)2.45684986
188platelet degranulation (GO:0002576)2.44974805
189positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.44305679
190cellular extravasation (GO:0045123)2.44057785
191hepatocyte apoptotic process (GO:0097284)2.42605193
192phospholipid scrambling (GO:0017121)2.42091703
193microglial cell activation (GO:0001774)2.38788700
194regulation of mast cell activation involved in immune response (GO:0033006)2.38326456
195negative regulation of thymocyte apoptotic process (GO:0070244)2.38198874
196mature B cell differentiation involved in immune response (GO:0002313)2.37397314
197positive regulation of endothelial cell differentiation (GO:0045603)2.37396311
198positive regulation of coagulation (GO:0050820)2.35452807
199positive regulation of isotype switching (GO:0045830)2.33365453
200regulation of mitochondrial depolarization (GO:0051900)2.33290975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.81831606
2SCL_19346495_ChIP-Seq_HPC-7_Human4.43846658
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83339672
4EZH2_22144423_ChIP-Seq_EOC_Human3.62918875
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.22885812
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21560672
7RUNX_20019798_ChIP-Seq_JUKART_Human2.79197274
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.73830433
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60859019
10GATA1_22025678_ChIP-Seq_K562_Human2.46544477
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.41146971
12DROSHA_22980978_ChIP-Seq_HELA_Human2.26795050
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.21579582
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17908825
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17706616
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.15935945
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14727186
18GATA2_19941826_ChIP-Seq_K562_Human2.12848581
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12344093
20SPI1_23127762_ChIP-Seq_K562_Human2.11845346
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.10363296
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.05527720
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03285386
24MYB_26560356_Chip-Seq_TH2_Human2.02580830
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01821559
26* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.97766321
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.91367000
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87805035
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84947191
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.84688703
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.84440734
32GATA1_19941827_ChIP-Seq_MEL_Mouse1.83237183
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80125252
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80024265
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76626347
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.74460691
37KDM2B_26808549_Chip-Seq_K562_Human1.73436119
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71417094
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71048564
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70517831
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70517831
42NR3C1_23031785_ChIP-Seq_PC12_Mouse1.70329470
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69557097
44ZNF263_19887448_ChIP-Seq_K562_Human1.69111565
45REST_21632747_ChIP-Seq_MESCs_Mouse1.67636610
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61969592
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59642601
48GBX2_23144817_ChIP-Seq_PC3_Human1.59539375
49TBX20_22328084_ChIP-Seq_HEART_Mouse1.54950485
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.54950485
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.52756215
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52586875
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.52536901
54MYB_26560356_Chip-Seq_TH1_Human1.51395300
55GATA3_27048872_Chip-Seq_THYMUS_Human1.50221083
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.49057985
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.48093343
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.47672813
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45724527
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45139451
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45113876
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.43091330
63* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42317513
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41423816
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41327021
66* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39862881
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39779618
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39587422
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38880103
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37258761
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36807840
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36806242
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36379641
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33943859
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33943859
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.32856466
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32077610
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32038070
79GATA3_26560356_Chip-Seq_TH2_Human1.31790899
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31582383
81SMAD4_21799915_ChIP-Seq_A2780_Human1.30487648
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30407950
83* SPI1_23547873_ChIP-Seq_NB4_Human1.29183481
84STAT3_23295773_ChIP-Seq_U87_Human1.28740454
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28607690
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28587429
87TAF15_26573619_Chip-Seq_HEK293_Human1.26828092
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26660312
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.26388059
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23334652
91AR_19668381_ChIP-Seq_PC3_Human1.23286775
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22427206
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22270258
94BCAT_22108803_ChIP-Seq_LS180_Human1.22074231
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22005645
96AR_21572438_ChIP-Seq_LNCaP_Human1.21976608
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21584830
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21404835
99EZH2_27304074_Chip-Seq_ESCs_Mouse1.21304577
100* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.20780544
101* KDM2B_26808549_Chip-Seq_DND41_Human1.20742507
102KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20563324
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20294108
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20079290
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19980305
106ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17239179
107* VDR_24787735_ChIP-Seq_THP-1_Human1.16577155
108AHR_22903824_ChIP-Seq_MCF-7_Human1.15475064
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15214533
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.13504794
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13338382
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.12777250
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11143879
114ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09877979
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09816471
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09496342
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.09373819
118CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09313120
119GATA1_19941826_ChIP-Seq_K562_Human1.08988814
120* TET1_21490601_ChIP-Seq_MESCs_Mouse1.07586929
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07181196
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06897590
123FOXA2_19822575_ChIP-Seq_HepG2_Human1.06735898
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06584331
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06119532
126CTCF_27219007_Chip-Seq_Bcells_Human1.05621178
127* UTX_26944678_Chip-Seq_JUKART_Human1.03223614
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02586438
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02060790
130ISL1_27105846_Chip-Seq_CPCs_Mouse1.02060625
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01918806
132* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01777840
133SALL4_22934838_ChIP-ChIP_CD34+_Human1.01389691
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01229803
135PU_27001747_Chip-Seq_BMDM_Mouse1.00682238
136ARNT_22903824_ChIP-Seq_MCF-7_Human1.00413307
137SMAD4_21741376_ChIP-Seq_HESCs_Human1.00337251
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99213012
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98373113
140TCF4_23295773_ChIP-Seq_U87_Human0.98176515
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97760335
142* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97513048
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97478117
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95935527
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95922881
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95686699
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95389200
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.95374167
149CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94280225
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94017894
151* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93350767
152CREB1_26743006_Chip-Seq_LNCaP_Human0.93203987
153THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93024342
154VDR_24763502_ChIP-Seq_THP-1_Human0.92806159
155MAF_26560356_Chip-Seq_TH1_Human0.92414472
156* RUNX1_27514584_Chip-Seq_MCF-7_Human0.92226807
157IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91327280
158* E2F1_18555785_Chip-Seq_ESCs_Mouse0.90545952
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90335880
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.90214589
161HTT_18923047_ChIP-ChIP_STHdh_Human0.89502997
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89440508
163GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89365494
164AR_25329375_ChIP-Seq_VCAP_Human0.89316817
165SMAD3_21741376_ChIP-Seq_HESCs_Human0.88636582
166* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88476597
167SMRT_27268052_Chip-Seq_Bcells_Human0.87766123
168* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87536817
169RXR_22108803_ChIP-Seq_LS180_Human0.87438683
170FOXO3_23340844_ChIP-Seq_DLD1_Human0.87096314
171RING1B_27294783_Chip-Seq_ESCs_Mouse0.87087406
172CLOCK_20551151_ChIP-Seq_293T_Human0.86862295
173* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86802669
174* P53_22387025_ChIP-Seq_ESCs_Mouse0.86611900
175P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85462564
176NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85249055
177CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84333660
178TCF7_22412390_ChIP-Seq_EML_Mouse0.83821061
179* NANOG_18555785_Chip-Seq_ESCs_Mouse0.82167236
180PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81505147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.56505684
2MP0002837_dystrophic_cardiac_calcinosis4.64478901
3MP0003646_muscle_fatigue4.41754709
4MP0003724_increased_susceptibility_to3.60899970
5MP0000751_myopathy3.57825508
6MP0004084_abnormal_cardiac_muscle3.44626153
7MP0008004_abnormal_stomach_pH3.41102217
8MP0000465_gastrointestinal_hemorrhage3.36787477
9MP0004215_abnormal_myocardial_fiber3.29533658
10MP0004859_abnormal_synaptic_plasticity3.20442659
11MP0004036_abnormal_muscle_relaxation3.00863036
12MP0003828_pulmonary_edema2.77323412
13MP0001835_abnormal_antigen_presentation2.62742667
14MP0004270_analgesia2.41605096
15MP0003303_peritoneal_inflammation2.37951531
16MP0002909_abnormal_adrenal_gland2.37798645
17MP0004130_abnormal_muscle_cell2.35231924
18MP0000749_muscle_degeneration2.27527811
19MP0004145_abnormal_muscle_electrophysio2.25694860
20MP0000569_abnormal_digit_pigmentation2.23412280
21MP0002822_catalepsy2.20094708
22MP0003763_abnormal_thymus_physiology2.18061602
23MP0004087_abnormal_muscle_fiber2.16403888
24MP0008775_abnormal_heart_ventricle2.11591676
25MP0000013_abnormal_adipose_tissue2.07218147
26MP0005620_abnormal_muscle_contractility1.97147736
27MP0005000_abnormal_immune_tolerance1.97122323
28MP0002972_abnormal_cardiac_muscle1.95940322
29MP0001800_abnormal_humoral_immune1.95070886
30MP0001984_abnormal_olfaction1.94363243
31MP0003635_abnormal_synaptic_transmissio1.92623869
32MP0002398_abnormal_bone_marrow1.92093269
33MP0005330_cardiomyopathy1.90591322
34MP0003436_decreased_susceptibility_to1.90103130
35MP0002269_muscular_atrophy1.81843427
36MP0004233_abnormal_muscle_weight1.80600080
37MP0004484_altered_response_of1.76657613
38MP0003137_abnormal_impulse_conducting1.74737921
39MP0004085_abnormal_heartbeat1.73938597
40MP0001545_abnormal_hematopoietic_system1.73272199
41MP0005397_hematopoietic_system_phenotyp1.73272199
42MP0004808_abnormal_hematopoietic_stem1.72406631
43MP0002396_abnormal_hematopoietic_system1.71990309
44MP0004510_myositis1.67829632
45MP0002734_abnormal_mechanical_nocicepti1.67472718
46MP0009780_abnormal_chondrocyte_physiolo1.66274067
47MP0002723_abnormal_immune_serum1.65095507
48MP0003866_abnormal_defecation1.64686086
49MP0008961_abnormal_basal_metabolism1.63537672
50MP0002735_abnormal_chemical_nociception1.63302035
51MP0002106_abnormal_muscle_physiology1.61024949
52MP0002420_abnormal_adaptive_immunity1.60896978
53MP0001851_eye_inflammation1.59450875
54MP0010155_abnormal_intestine_physiology1.58732454
55MP0001819_abnormal_immune_cell1.58470289
56MP0000747_muscle_weakness1.57242485
57MP0004947_skin_inflammation1.56804786
58MP0001968_abnormal_touch/_nociception1.54483091
59MP0000689_abnormal_spleen_morphology1.54357644
60MP0005671_abnormal_response_to1.53097175
61MP0002452_abnormal_antigen_presenting1.52981039
62MP0004185_abnormal_adipocyte_glucose1.51684095
63MP0000759_abnormal_skeletal_muscle1.51273131
64MP0002148_abnormal_hypersensitivity_rea1.50070122
65MP0004858_abnormal_nervous_system1.49111938
66MP0003221_abnormal_cardiomyocyte_apopto1.48641396
67MP0010630_abnormal_cardiac_muscle1.47441906
68MP0000003_abnormal_adipose_tissue1.47112236
69MP0001544_abnormal_cardiovascular_syste1.46311205
70MP0005385_cardiovascular_system_phenoty1.46311205
71MP0002063_abnormal_learning/memory/cond1.44378953
72MP0002877_abnormal_melanocyte_morpholog1.43076807
73MP0002419_abnormal_innate_immunity1.43066206
74MP0003172_abnormal_lysosome_physiology1.42911641
75MP0002722_abnormal_immune_system1.41911789
76MP0006138_congestive_heart_failure1.40616490
77MP0003329_amyloid_beta_deposits1.40143821
78MP0005666_abnormal_adipose_tissue1.39465861
79MP0000716_abnormal_immune_system1.38239855
80MP0008569_lethality_at_weaning1.36617110
81MP0009046_muscle_twitch1.36189122
82MP0002733_abnormal_thermal_nociception1.33522863
83MP0006072_abnormal_retinal_apoptosis1.33230689
84MP0000015_abnormal_ear_pigmentation1.33218777
85MP0000230_abnormal_systemic_arterial1.31631693
86MP0004924_abnormal_behavior1.31454958
87MP0005386_behavior/neurological_phenoty1.31454958
88MP0000703_abnormal_thymus_morphology1.28569536
89MP0003183_abnormal_peptide_metabolism1.28145685
90MP0002429_abnormal_blood_cell1.27991285
91MP0005369_muscle_phenotype1.27541712
92MP0005375_adipose_tissue_phenotype1.26399843
93MP0002272_abnormal_nervous_system1.25153060
94MP0005387_immune_system_phenotype1.23611339
95MP0001790_abnormal_immune_system1.23611339
96MP0001970_abnormal_pain_threshold1.20926387
97MP0005187_abnormal_penis_morphology1.19929312
98MP0003191_abnormal_cellular_cholesterol1.17802450
99MP0002234_abnormal_pharynx_morphology1.17117219
100MP0005670_abnormal_white_adipose1.16812534
101MP0002332_abnormal_exercise_endurance1.14657059
102MP0005174_abnormal_tail_pigmentation1.14538163
103MP0005025_abnormal_response_to1.14282629
104MP0001533_abnormal_skeleton_physiology1.13393672
105MP0009745_abnormal_behavioral_response1.12624039
106MP0002067_abnormal_sensory_capabilities1.12481368
107MP0000750_abnormal_muscle_regeneration1.11312911
108MP0004811_abnormal_neuron_physiology1.08999442
109MP0002184_abnormal_innervation1.08852317
110MP0005409_darkened_coat_color1.07059929
111MP0002405_respiratory_system_inflammati1.06834179
112MP0009763_increased_sensitivity_to1.06798465
113MP0004043_abnormal_pH_regulation1.05065746
114MP0003045_fibrosis1.04083727
115MP0008874_decreased_physiological_sensi1.03511323
116MP0010234_abnormal_vibrissa_follicle1.02859354
117MP0002736_abnormal_nociception_after1.02781034
118MP0005551_abnormal_eye_electrophysiolog1.01840762
119MP0002127_abnormal_cardiovascular_syste1.01837678
120MP0002572_abnormal_emotion/affect_behav1.00819205
121MP0001845_abnormal_inflammatory_respons1.00514297
122MP0002064_seizures1.00297492
123MP0005646_abnormal_pituitary_gland0.99183487
124MP0005423_abnormal_somatic_nervous0.98705690
125MP0000249_abnormal_blood_vessel0.97837601
126MP0000685_abnormal_immune_system0.96699868
127MP0001486_abnormal_startle_reflex0.96425882
128MP0005535_abnormal_body_temperature0.94692892
129MP0001502_abnormal_circadian_rhythm0.94494482
130MP0009765_abnormal_xenobiotic_induced0.93423372
131MP0001299_abnormal_eye_distance/0.93064405
132MP0009333_abnormal_splenocyte_physiolog0.91689052
133MP0008877_abnormal_DNA_methylation0.91641971
134MP0003787_abnormal_imprinting0.88417467
135MP0003566_abnormal_cell_adhesion0.87723175
136MP0000955_abnormal_spinal_cord0.87634859
137MP0003705_abnormal_hypodermis_morpholog0.87360849
138MP0002078_abnormal_glucose_homeostasis0.86540297
139MP0003879_abnormal_hair_cell0.85725871
140MP0002971_abnormal_brown_adipose0.85574727
141MP0006276_abnormal_autonomic_nervous0.85044429
142MP0000343_altered_response_to0.84969386
143MP0009697_abnormal_copulation0.84239143
144MP0002229_neurodegeneration0.82819752
145MP0009278_abnormal_bone_marrow0.82702340
146MP0002998_abnormal_bone_remodeling0.82082385
147MP0003633_abnormal_nervous_system0.80019158
148MP0004134_abnormal_chest_morphology0.80010456
149MP0003656_abnormal_erythrocyte_physiolo0.78509274
150MP0004883_abnormal_blood_vessel0.77442230
151MP0004147_increased_porphyrin_level0.76729757
152MP0002882_abnormal_neuron_morphology0.76519482
153MP0001440_abnormal_grooming_behavior0.75543266
154MP0002132_abnormal_respiratory_system0.75538225
155MP0005410_abnormal_fertilization0.74830454
156MP0001501_abnormal_sleep_pattern0.73521579
157MP0005165_increased_susceptibility_to0.73215186
158MP0002066_abnormal_motor_capabilities/c0.72627234
159MP0003880_abnormal_central_pattern0.72414776
160MP0002009_preneoplasia0.72414463
161MP0000266_abnormal_heart_morphology0.71748878
162MP0003638_abnormal_response/metabolism_0.71380897
163MP0003091_abnormal_cell_migration0.70008993
164MP0002090_abnormal_vision0.69761332
165MP0003300_gastrointestinal_ulcer0.69203884
166MP0002557_abnormal_social/conspecific_i0.68739669
167MP0001986_abnormal_taste_sensitivity0.68557454
168MP0010368_abnormal_lymphatic_system0.66082238
169MP0009764_decreased_sensitivity_to0.65915879
170MP0005075_abnormal_melanosome_morpholog0.65368269
171MP0001663_abnormal_digestive_system0.65056426
172MP0001529_abnormal_vocalization0.64800171
173MP0001765_abnormal_ion_homeostasis0.64125618
174MP0003252_abnormal_bile_duct0.64047894
175MP0004381_abnormal_hair_follicle0.63749388
176MP0008872_abnormal_physiological_respon0.63742020

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.19066047
2Increased mean platelet volume (HP:0011877)7.43304647
3Petechiae (HP:0000967)7.23712606
4Menorrhagia (HP:0000132)7.19886909
5Abnormal platelet volume (HP:0011876)7.15765982
6Epistaxis (HP:0000421)6.42635838
7Gingival bleeding (HP:0000225)6.07447665
8Purpura (HP:0000979)5.57732341
9Sudden death (HP:0001699)5.01166315
10Abnormal platelet function (HP:0011869)4.51928717
11Impaired platelet aggregation (HP:0003540)4.51928717
12Exercise-induced myalgia (HP:0003738)4.09712539
13Bundle branch block (HP:0011710)4.09532315
14Spontaneous hematomas (HP:0007420)4.05487633
15Atrial fibrillation (HP:0005110)4.00551100
16Ventricular fibrillation (HP:0001663)3.97315231
17Hyporeflexia of lower limbs (HP:0002600)3.91417214
18Syncope (HP:0001279)3.87959062
19Primary atrial arrhythmia (HP:0001692)3.80144674
20Prolonged QT interval (HP:0001657)3.74465165
21Supraventricular tachycardia (HP:0004755)3.55424197
22Myokymia (HP:0002411)3.52105754
23Supraventricular arrhythmia (HP:0005115)3.48586666
24Myoglobinuria (HP:0002913)3.46843582
25Hyperlipoproteinemia (HP:0010980)3.46774738
26Muscle fiber splitting (HP:0003555)3.46384330
27Difficulty running (HP:0009046)3.41299130
28Exercise-induced muscle cramps (HP:0003710)3.40373791
29Poikilocytosis (HP:0004447)3.40175710
30Ventricular tachycardia (HP:0004756)3.32743518
31Calf muscle hypertrophy (HP:0008981)3.21637702
32Acanthocytosis (HP:0001927)3.18199700
33Central scotoma (HP:0000603)3.12476193
34Atrioventricular block (HP:0001678)3.10937938
35Dysmetric saccades (HP:0000641)3.09348894
36Heart block (HP:0012722)3.08087006
37Action tremor (HP:0002345)3.05572296
38Ventricular arrhythmia (HP:0004308)3.04570049
39Autoimmune hemolytic anemia (HP:0001890)2.99668408
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.95405376
41Right ventricular cardiomyopathy (HP:0011663)2.95121623
42Muscle hypertrophy of the lower extremities (HP:0008968)2.93996406
43Palpitations (HP:0001962)2.92288035
44Myotonia (HP:0002486)2.91748285
45Pheochromocytoma (HP:0002666)2.90236313
46Abnormality of the common coagulation pathway (HP:0010990)2.85350468
47Bruising susceptibility (HP:0000978)2.84280009
48Abnormal atrioventricular conduction (HP:0005150)2.83856713
49Abnormal EKG (HP:0003115)2.81352359
50Stomatitis (HP:0010280)2.80900980
51Conjunctival telangiectasia (HP:0000524)2.76523497
52Abnormality of the calf musculature (HP:0001430)2.74378429
53Lipoatrophy (HP:0100578)2.68657818
54Abnormality of the heme biosynthetic pathway (HP:0010472)2.68117040
55T lymphocytopenia (HP:0005403)2.66385467
56Subaortic stenosis (HP:0001682)2.63381667
57Abnormality of the left ventricular outflow tract (HP:0011103)2.63381667
58Eczematoid dermatitis (HP:0000976)2.60361595
59Dyschromatopsia (HP:0007641)2.59398053
60Abnormality of T cell number (HP:0011839)2.58624989
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.51421738
62Visual hallucinations (HP:0002367)2.49934066
63Insulin-resistant diabetes mellitus (HP:0000831)2.49191816
64EMG: myopathic abnormalities (HP:0003458)2.48594539
65Elevated erythrocyte sedimentation rate (HP:0003565)2.47715631
66Insidious onset (HP:0003587)2.46552686
67Termporal pattern (HP:0011008)2.46552686
68Asymmetric septal hypertrophy (HP:0001670)2.45709186
69Hypercortisolism (HP:0001578)2.44865641
70Ketoacidosis (HP:0001993)2.43040399
71Ulnar claw (HP:0001178)2.40570649
72Increased connective tissue (HP:0009025)2.39038048
73Focal seizures (HP:0007359)2.38838425
74Long toe (HP:0010511)2.38575614
75Papillary thyroid carcinoma (HP:0002895)2.38575562
76Neuroendocrine neoplasm (HP:0100634)2.37699696
77Focal motor seizures (HP:0011153)2.35476815
78Dilated cardiomyopathy (HP:0001644)2.32595221
79Agammaglobulinemia (HP:0004432)2.32522980
80Panhypogammaglobulinemia (HP:0003139)2.32286610
81Inflammation of the large intestine (HP:0002037)2.31122697
82Depression (HP:0000716)2.31040486
83Chest pain (HP:0100749)2.30729942
84Hyperglycemia (HP:0003074)2.29439137
85Difficulty climbing stairs (HP:0003551)2.29385900
86Arterial thrombosis (HP:0004420)2.29121792
87Hamartoma of the eye (HP:0010568)2.24982601
88Resting tremor (HP:0002322)2.24770752
89EMG: neuropathic changes (HP:0003445)2.23444202
90Truncal ataxia (HP:0002078)2.22306120
91Abnormal pupillary function (HP:0007686)2.21805470
92Abnormality of binocular vision (HP:0011514)2.20795227
93Diplopia (HP:0000651)2.20795227
94Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19818756
95Nemaline bodies (HP:0003798)2.19275369
96Gastrointestinal inflammation (HP:0004386)2.19099756
97Febrile seizures (HP:0002373)2.18078589
98Urinary bladder sphincter dysfunction (HP:0002839)2.14648342
99Encephalitis (HP:0002383)2.14031677
100Recurrent abscess formation (HP:0002722)2.13701092
101Recurrent fungal infections (HP:0002841)2.12987572
102Atonic seizures (HP:0010819)2.11835611
103Abnormality of T cells (HP:0002843)2.11356640
104Urinary urgency (HP:0000012)2.11333183
105Left ventricular hypertrophy (HP:0001712)2.10972550
106Foot dorsiflexor weakness (HP:0009027)2.10262475
107Increased variability in muscle fiber diameter (HP:0003557)2.09508113
108Thrombocytosis (HP:0001894)2.08616858
109Muscle stiffness (HP:0003552)2.07714142
110Joint swelling (HP:0001386)2.07187162
111Thyroid carcinoma (HP:0002890)2.06300579
112Recurrent viral infections (HP:0004429)2.06101781
113Chronic diarrhea (HP:0002028)2.05566977
114Obstructive lung disease (HP:0006536)2.04707479
115Chronic obstructive pulmonary disease (HP:0006510)2.04707479
116Muscle fiber inclusion bodies (HP:0100299)2.04008552
117Abnormality of the prostate (HP:0008775)2.03229609
118Scotoma (HP:0000575)2.03017270
119Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02022530
120Rhabdomyolysis (HP:0003201)2.00692895
121Abnormality of the foot musculature (HP:0001436)2.00682455
122Colitis (HP:0002583)1.99949129
123Spontaneous abortion (HP:0005268)1.99702826
124Rapidly progressive (HP:0003678)1.99380433
125Congenital stationary night blindness (HP:0007642)1.98820065
126Pustule (HP:0200039)1.98685714
127Ankle clonus (HP:0011448)1.98506339
128Tinnitus (HP:0000360)1.98361905
129Male infertility (HP:0003251)1.97958352
130Hypoglycemic coma (HP:0001325)1.96353307
131Dysdiadochokinesis (HP:0002075)1.94949142
132Hammertoe (HP:0001765)1.94660896
133Recurrent bacterial skin infections (HP:0005406)1.93097668
134Hyperinsulinemic hypoglycemia (HP:0000825)1.92483188
135Leukocytosis (HP:0001974)1.91915110
136Neoplasm of the heart (HP:0100544)1.88897070
137Steppage gait (HP:0003376)1.86673317
138Abnormality of the lower motor neuron (HP:0002366)1.86472538
139Absence seizures (HP:0002121)1.86254640
140Distal lower limb amyotrophy (HP:0008944)1.85957105
141Generalized tonic-clonic seizures (HP:0002069)1.85810227
142Progressive cerebellar ataxia (HP:0002073)1.85372810
143Insomnia (HP:0100785)1.85249650
144Granulocytopenia (HP:0001913)1.85119323
145Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84937009
146Postural instability (HP:0002172)1.84406999
147Anxiety (HP:0000739)1.83435456
148Upper limb muscle weakness (HP:0003484)1.82426238
149Paralysis (HP:0003470)1.82019239
150Abnormality of iron homeostasis (HP:0011031)1.81727385
151Supranuclear gaze palsy (HP:0000605)1.79988401
152Meningitis (HP:0001287)1.79900620
153Myositis (HP:0100614)1.79716476
154Aortic aneurysm (HP:0004942)1.79656080
155Enlarged penis (HP:0000040)1.79527376
156Impaired vibration sensation in the lower limbs (HP:0002166)1.79458547
157Polycythemia (HP:0001901)1.78863521
158Papilledema (HP:0001085)1.78752256
159Vertigo (HP:0002321)1.78730293
160Impaired social interactions (HP:0000735)1.78393744
161Abnormal social behavior (HP:0012433)1.78393744
162Acute myeloid leukemia (HP:0004808)1.77686902
163Abnormality of skeletal muscle fiber size (HP:0012084)1.77149682
164Hyperthyroidism (HP:0000836)1.76490549
165Cholelithiasis (HP:0001081)1.75817677
166Stomach cancer (HP:0012126)1.75668118
167Lower limb amyotrophy (HP:0007210)1.74246063
168Areflexia of lower limbs (HP:0002522)1.74213628
169Acute hepatic failure (HP:0006554)1.73963254
170Abnormality of T cell physiology (HP:0011840)1.73380959
171Upper limb amyotrophy (HP:0009129)1.72866220
172Distal upper limb amyotrophy (HP:0007149)1.72866220
173Mask-like facies (HP:0000298)1.72380932
174Cerebral aneurysm (HP:0004944)1.72371646
175Cellulitis (HP:0100658)1.70128209
176Eosinophilia (HP:0001880)1.65254718
177Fatigue (HP:0012378)1.62281089
178Vasculitis (HP:0002633)1.61839867
179Verrucae (HP:0200043)1.60793306
180Papilloma (HP:0012740)1.60793306
181Abnormality of macrophages (HP:0004311)1.60712611
182Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59635928
183Increased density of long bones (HP:0006392)1.59562071
184Poor eye contact (HP:0000817)1.56788510
185Abnormality of transition element cation homeostasis (HP:0011030)1.56458737
186Episodic fever (HP:0001954)1.55042461
187Albinism (HP:0001022)1.52801231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.05971199
2MAP3K93.34103403
3KSR23.23429013
4TEC3.21748586
5LMTK22.97452747
6TRIB32.78217934
7BTK2.76356107
8PIK3CG2.69053264
9SYK2.47812931
10PHKG12.43441598
11PHKG22.43441598
12FES2.29191581
13MAP3K42.21094577
14MST42.15948551
15PRKD32.14344317
16BMPR22.10953594
17PAK62.10362682
18TTN2.06194270
19MAP2K32.02510821
20DMPK1.93489974
21ITK1.91595652
22NTRK31.89732254
23TAOK11.85745365
24LATS21.83631313
25MAPKAPK31.83617852
26ZAP701.76904011
27RIPK11.72155268
28HCK1.70624981
29CAMK1G1.70010258
30MYLK1.65539700
31EEF2K1.61390061
32BMX1.60692663
33OBSCN1.56525997
34PINK11.56157590
35CAMK1D1.55051942
36RET1.54594493
37PRPF4B1.54300321
38TXK1.52091148
39MINK11.51410694
40MAP2K41.46576485
41PDK31.45961637
42PDK41.45961637
43GRK61.45833451
44PKN21.45596146
45MAP3K131.45173435
46STK381.44271168
47MAP4K11.42317172
48MAP3K141.38959314
49JAK31.37691296
50CSF1R1.36874423
51NEK11.35828066
52MAP3K61.30517247
53NTRK11.29166093
54KSR11.26490789
55MAP3K21.22115525
56PAK31.18658734
57INSRR1.18052059
58LATS11.15197440
59AKT31.15101436
60CAMKK11.13504771
61KIT1.09856336
62RAF11.09115791
63SGK31.08764234
64PRKAA11.08345636
65LYN1.07564469
66TRPM71.05917487
67EPHA41.05697870
68SGK21.03251818
69EPHA31.02345184
70IKBKB1.01850805
71PRKCH1.00665540
72WNK11.00412083
73MAP3K71.00277225
74LCK0.97996240
75ARAF0.94813326
76FRK0.92008900
77SGK4940.91879505
78SGK2230.91879505
79IKBKE0.91653546
80DAPK20.90395044
81CDC42BPA0.89707929
82MAP3K10.88894288
83PRKAA20.88728885
84CAMKK20.88585057
85PDGFRA0.87669984
86MAP2K70.85239824
87MUSK0.84452009
88DYRK1A0.83299999
89PLK20.83085058
90CDK120.82565129
91MARK20.82528124
92HIPK20.81909581
93EIF2AK30.80308682
94SCYL20.77529410
95FLT30.77000242
96PIK3CA0.76524630
97MAPK70.74769515
98CDK50.74678305
99NTRK20.74510092
100MARK30.73963188
101BCKDK0.73626060
102BLK0.72002236
103PIM10.71624627
104PRKD10.71347934
105WNK40.71200033
106CSK0.70441534
107MAP2K10.69872248
108CDK90.66879409
109TNK20.66814098
110EIF2AK10.65885726
111TYRO30.65480786
112MATK0.65287083
113PRKCQ0.65004669
114RPS6KA20.64603187
115PDK10.63882728
116IRAK10.62790426
117MAP3K30.62747716
118PDPK10.62373222
119TIE10.62082511
120STK30.62052894
121TNIK0.62041843
122STK110.61091200
123TBK10.59884517
124TAOK30.59666004
125GRK50.57565099
126FGR0.57353783
127PRKD20.57011256
128NLK0.56338942
129YES10.54080563
130FYN0.53373136
131FER0.51862212
132CAMK10.50855555
133MAP3K50.49220703
134FGFR30.47065356
135MARK10.46637508
136ROCK10.46164738
137BRAF0.46021754
138CAMK2D0.45792027
139MAPK120.45465440
140CAMK2A0.44227086
141MAPK130.43478080
142JAK20.42784544
143RPS6KA30.41954486
144ABL10.41901208
145SGK10.40998597
146STK240.40735029
147MAPK110.40466576
148JAK10.39264792
149MAPK30.37779234
150MAPK100.37613900
151PAK20.37589643
152CAMK40.37223836
153MAPK40.36303725
154NUAK10.36211459
155PDK20.35254078
156STK40.35194700
157PTK2B0.35148658
158MAPKAPK50.35067363
159PDGFRB0.34825374
160CCNB10.33482482
161MTOR0.32401331

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.88716247
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60513509
3Olfactory transduction_Homo sapiens_hsa047402.26802406
4B cell receptor signaling pathway_Homo sapiens_hsa046622.25486346
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.11969604
6Dilated cardiomyopathy_Homo sapiens_hsa054142.01622054
7Hematopoietic cell lineage_Homo sapiens_hsa046401.96525713
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.95397893
9Insulin secretion_Homo sapiens_hsa049111.86602038
10T cell receptor signaling pathway_Homo sapiens_hsa046601.84295860
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82051258
12Type II diabetes mellitus_Homo sapiens_hsa049301.74975663
13Circadian entrainment_Homo sapiens_hsa047131.74145672
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69081770
15Long-term potentiation_Homo sapiens_hsa047201.61503653
16Cardiac muscle contraction_Homo sapiens_hsa042601.57152159
17Synaptic vesicle cycle_Homo sapiens_hsa047211.56264967
18Circadian rhythm_Homo sapiens_hsa047101.55434061
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54375313
20Dorso-ventral axis formation_Homo sapiens_hsa043201.50977815
21Oxytocin signaling pathway_Homo sapiens_hsa049211.50079071
22GnRH signaling pathway_Homo sapiens_hsa049121.49420496
23Renin secretion_Homo sapiens_hsa049241.49059541
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48696237
25Cholinergic synapse_Homo sapiens_hsa047251.46491001
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44109446
27Gastric acid secretion_Homo sapiens_hsa049711.43788006
28Dopaminergic synapse_Homo sapiens_hsa047281.43652063
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42934351
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.42736782
31Morphine addiction_Homo sapiens_hsa050321.41726759
32Salivary secretion_Homo sapiens_hsa049701.40258423
33Leishmaniasis_Homo sapiens_hsa051401.40117200
34Chemokine signaling pathway_Homo sapiens_hsa040621.38232100
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37088176
36GABAergic synapse_Homo sapiens_hsa047271.36631591
37Amphetamine addiction_Homo sapiens_hsa050311.34494751
38Osteoclast differentiation_Homo sapiens_hsa043801.34122674
39Glucagon signaling pathway_Homo sapiens_hsa049221.33761938
40Acute myeloid leukemia_Homo sapiens_hsa052211.33588602
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32390361
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31894229
43Glutamatergic synapse_Homo sapiens_hsa047241.31636317
44Insulin signaling pathway_Homo sapiens_hsa049101.30085729
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29827773
46Graft-versus-host disease_Homo sapiens_hsa053321.29525758
47Allograft rejection_Homo sapiens_hsa053301.28653157
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26886936
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26818252
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26690066
51Primary immunodeficiency_Homo sapiens_hsa053401.24003460
52mTOR signaling pathway_Homo sapiens_hsa041501.22355051
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22306194
54Autoimmune thyroid disease_Homo sapiens_hsa053201.21012449
55Taste transduction_Homo sapiens_hsa047421.19740708
56cAMP signaling pathway_Homo sapiens_hsa040241.19671405
57Estrogen signaling pathway_Homo sapiens_hsa049151.18218026
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16800779
59Insulin resistance_Homo sapiens_hsa049311.16708171
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13304897
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12621159
62Propanoate metabolism_Homo sapiens_hsa006401.10888820
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10180272
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08748993
65Gap junction_Homo sapiens_hsa045401.08574561
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.08531683
67Intestinal immune network for IgA production_Homo sapiens_hsa046721.07443322
68Asthma_Homo sapiens_hsa053101.06721169
69Vascular smooth muscle contraction_Homo sapiens_hsa042701.06621191
70Calcium signaling pathway_Homo sapiens_hsa040201.06417148
71Cocaine addiction_Homo sapiens_hsa050301.06407991
72Leukocyte transendothelial migration_Homo sapiens_hsa046701.06200187
73VEGF signaling pathway_Homo sapiens_hsa043701.05807979
74Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00899721
75AMPK signaling pathway_Homo sapiens_hsa041521.00494477
76Glioma_Homo sapiens_hsa052141.00274196
77Nicotine addiction_Homo sapiens_hsa050331.00032522
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99541481
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97948502
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97829441
81Arachidonic acid metabolism_Homo sapiens_hsa005900.95476712
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95363407
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95122611
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93820033
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93671865
86Oocyte meiosis_Homo sapiens_hsa041140.93235477
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92422209
88Staphylococcus aureus infection_Homo sapiens_hsa051500.91255035
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.90318189
90Long-term depression_Homo sapiens_hsa047300.87953413
91Inositol phosphate metabolism_Homo sapiens_hsa005620.87654266
92Toxoplasmosis_Homo sapiens_hsa051450.87235397
93Measles_Homo sapiens_hsa051620.87016742
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.86444804
95Type I diabetes mellitus_Homo sapiens_hsa049400.85859223
96Ovarian steroidogenesis_Homo sapiens_hsa049130.85443211
97Shigellosis_Homo sapiens_hsa051310.83612866
98Endometrial cancer_Homo sapiens_hsa052130.82576274
99Prolactin signaling pathway_Homo sapiens_hsa049170.81686999
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.81647390
101Serotonergic synapse_Homo sapiens_hsa047260.80322597
102Fatty acid degradation_Homo sapiens_hsa000710.80031729
103Tuberculosis_Homo sapiens_hsa051520.79863630
104ECM-receptor interaction_Homo sapiens_hsa045120.79799030
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.79646796
106Non-small cell lung cancer_Homo sapiens_hsa052230.78900299
107Choline metabolism in cancer_Homo sapiens_hsa052310.78761564
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.77238920
109Phototransduction_Homo sapiens_hsa047440.75913757
110Renal cell carcinoma_Homo sapiens_hsa052110.75905200
111Thyroid hormone synthesis_Homo sapiens_hsa049180.74986923
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74919942
113Fatty acid biosynthesis_Homo sapiens_hsa000610.74813766
114ErbB signaling pathway_Homo sapiens_hsa040120.74698684
115Hepatitis B_Homo sapiens_hsa051610.73941355
116Pancreatic secretion_Homo sapiens_hsa049720.73808271
117Pyruvate metabolism_Homo sapiens_hsa006200.73401883
118Fatty acid metabolism_Homo sapiens_hsa012120.72308494
119Pancreatic cancer_Homo sapiens_hsa052120.71432742
120Regulation of autophagy_Homo sapiens_hsa041400.70411908
121MAPK signaling pathway_Homo sapiens_hsa040100.70227806
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.69584401
123TNF signaling pathway_Homo sapiens_hsa046680.68569457
124Viral myocarditis_Homo sapiens_hsa054160.68519282
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67192581
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66422527
127Systemic lupus erythematosus_Homo sapiens_hsa053220.66329495
128Alcoholism_Homo sapiens_hsa050340.62027914
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60292361
130Influenza A_Homo sapiens_hsa051640.60109125
131FoxO signaling pathway_Homo sapiens_hsa040680.59875262
132Chronic myeloid leukemia_Homo sapiens_hsa052200.58717545
133Amoebiasis_Homo sapiens_hsa051460.57726168
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57344079
135Melanogenesis_Homo sapiens_hsa049160.56832152
136Viral carcinogenesis_Homo sapiens_hsa052030.55868744
137Carbon metabolism_Homo sapiens_hsa012000.54589951
138Bile secretion_Homo sapiens_hsa049760.52940331
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52480879
140Endocytosis_Homo sapiens_hsa041440.50043081
141Lysine degradation_Homo sapiens_hsa003100.50036306
142Colorectal cancer_Homo sapiens_hsa052100.49527582
143Rap1 signaling pathway_Homo sapiens_hsa040150.48975530
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.48007106
145Focal adhesion_Homo sapiens_hsa045100.47097638
146PPAR signaling pathway_Homo sapiens_hsa033200.47043796
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45762372
148Butanoate metabolism_Homo sapiens_hsa006500.44971874
149HIF-1 signaling pathway_Homo sapiens_hsa040660.42791365
150Ras signaling pathway_Homo sapiens_hsa040140.42772215

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