CNTD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.63191241
2axonemal dynein complex assembly (GO:0070286)5.51389201
3epithelial cilium movement (GO:0003351)5.36855366
4piRNA metabolic process (GO:0034587)5.09760242
5cilium movement (GO:0003341)4.77143990
6multicellular organism reproduction (GO:0032504)4.56355047
7motile cilium assembly (GO:0044458)4.55991165
8detection of light stimulus involved in visual perception (GO:0050908)4.39714401
9detection of light stimulus involved in sensory perception (GO:0050962)4.39714401
10water-soluble vitamin biosynthetic process (GO:0042364)4.34290623
11fusion of sperm to egg plasma membrane (GO:0007342)4.31903229
12DNA methylation involved in gamete generation (GO:0043046)4.29023914
13acrosome reaction (GO:0007340)4.22569990
14sperm motility (GO:0030317)4.17179877
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.14438713
16phosphorylated carbohydrate dephosphorylation (GO:0046838)4.05996315
17inositol phosphate dephosphorylation (GO:0046855)4.05996315
18establishment of protein localization to Golgi (GO:0072600)4.02738622
19male meiosis (GO:0007140)3.96308810
20protein targeting to Golgi (GO:0000042)3.91162722
21microtubule depolymerization (GO:0007019)3.82298610
22proteasome assembly (GO:0043248)3.77992170
23inositol phosphate catabolic process (GO:0071545)3.72037942
24GTP biosynthetic process (GO:0006183)3.68558055
25acrosome assembly (GO:0001675)3.57292255
26respiratory chain complex IV assembly (GO:0008535)3.56082760
27platelet dense granule organization (GO:0060155)3.50165631
28sperm-egg recognition (GO:0035036)3.47954511
29retrograde transport, vesicle recycling within Golgi (GO:0000301)3.47246445
30presynaptic membrane assembly (GO:0097105)3.44724097
31cytochrome complex assembly (GO:0017004)3.42359105
32spermatid development (GO:0007286)3.38633197
33protein complex biogenesis (GO:0070271)3.36684884
34proline transport (GO:0015824)3.34643272
35regulation of cilium movement (GO:0003352)3.34334988
36axon ensheathment in central nervous system (GO:0032291)3.32942069
37central nervous system myelination (GO:0022010)3.32942069
38reproduction (GO:0000003)3.30838659
39alanine transport (GO:0032328)3.26650245
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25409421
41protein localization to cilium (GO:0061512)3.25282023
42superoxide anion generation (GO:0042554)3.24329145
43male meiosis I (GO:0007141)3.23942304
44eosinophil chemotaxis (GO:0048245)3.23747478
45centriole assembly (GO:0098534)3.21604473
46plasma membrane fusion (GO:0045026)3.19066999
47protein localization to Golgi apparatus (GO:0034067)3.17527979
48single fertilization (GO:0007338)3.14872149
49cyclic nucleotide catabolic process (GO:0009214)3.12305635
50intraciliary transport (GO:0042073)3.12176620
51DNA ligation (GO:0006266)3.10498381
52cell wall macromolecule catabolic process (GO:0016998)3.08412016
53cell wall macromolecule metabolic process (GO:0044036)3.08412016
54dopamine transport (GO:0015872)3.05959654
55ventricular system development (GO:0021591)3.05844213
56adenosine metabolic process (GO:0046085)3.03693512
57presynaptic membrane organization (GO:0097090)3.03465329
58organelle membrane fusion (GO:0090174)3.01172063
59cell-cell recognition (GO:0009988)2.99870538
60polyol catabolic process (GO:0046174)2.98447878
61synaptonemal complex organization (GO:0070193)2.96931838
62regulation of type B pancreatic cell apoptotic process (GO:2000674)2.95610517
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.95456557
64NADH dehydrogenase complex assembly (GO:0010257)2.95456557
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95456557
66cytidine deamination (GO:0009972)2.95404508
67cytidine metabolic process (GO:0046087)2.95404508
68cytidine catabolic process (GO:0006216)2.95404508
69mitochondrial respiratory chain complex assembly (GO:0033108)2.93023826
70cAMP catabolic process (GO:0006198)2.92834591
71binding of sperm to zona pellucida (GO:0007339)2.92721528
72signal peptide processing (GO:0006465)2.90867849
73eosinophil migration (GO:0072677)2.90535481
74mannosylation (GO:0097502)2.88712466
75sperm capacitation (GO:0048240)2.87540040
76negative regulation of execution phase of apoptosis (GO:1900118)2.86923277
77electron transport chain (GO:0022900)2.86590981
78regulation of chronic inflammatory response (GO:0002676)2.83189464
79respiratory electron transport chain (GO:0022904)2.82510664
80regulation of protein kinase A signaling (GO:0010738)2.80880643
81response to xenobiotic stimulus (GO:0009410)2.80450981
82L-fucose catabolic process (GO:0042355)2.78815084
83fucose catabolic process (GO:0019317)2.78815084
84L-fucose metabolic process (GO:0042354)2.78815084
85UTP biosynthetic process (GO:0006228)2.77235277
86protein-cofactor linkage (GO:0018065)2.76883568
87positive regulation of protein homodimerization activity (GO:0090073)2.75182017
88postsynaptic membrane organization (GO:0001941)2.74016381
89autophagic vacuole fusion (GO:0000046)2.70863437
90cilium assembly (GO:0042384)2.69476886
91regulation of timing of cell differentiation (GO:0048505)2.69198654
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68692942
93protein K11-linked deubiquitination (GO:0035871)2.68138126
94centriole replication (GO:0007099)2.67173027
95magnesium ion transport (GO:0015693)2.66790919
96response to peptidoglycan (GO:0032494)2.66599907
97GPI anchor biosynthetic process (GO:0006506)2.66522558
98DNA deamination (GO:0045006)2.66131666
99ribosomal small subunit biogenesis (GO:0042274)2.65862450
100cilium organization (GO:0044782)2.64140222
101microtubule polymerization or depolymerization (GO:0031109)2.63465011
102positive regulation of meiosis (GO:0045836)2.62134622
103axoneme assembly (GO:0035082)2.62025575
104DNA catabolic process, exonucleolytic (GO:0000738)2.61333117
105chromosome organization involved in meiosis (GO:0070192)2.61094229
106positive regulation of meiotic cell cycle (GO:0051446)2.60958512
107nucleoside diphosphate phosphorylation (GO:0006165)2.60720662
108long-chain fatty acid biosynthetic process (GO:0042759)2.59913822
109regulation of germinal center formation (GO:0002634)2.58084511
110sphingoid metabolic process (GO:0046519)2.58053755
111mesenchymal cell differentiation involved in renal system development (GO:2001012)2.57053318
112mesenchymal cell differentiation involved in kidney development (GO:0072161)2.57053318
113keratinocyte development (GO:0003334)2.56923925
114energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56905282
115ATP synthesis coupled proton transport (GO:0015986)2.56905282
116regulation of meiosis I (GO:0060631)2.56588022
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55192576
118synaptonemal complex assembly (GO:0007130)2.54229896
119synapsis (GO:0007129)2.54173770
120transcription elongation from RNA polymerase III promoter (GO:0006385)2.53970694
121termination of RNA polymerase III transcription (GO:0006386)2.53970694
122positive regulation of defense response to virus by host (GO:0002230)2.53676361
123cellular ketone body metabolic process (GO:0046950)2.51298000
124positive regulation of interleukin-1 beta secretion (GO:0050718)2.50974307
125nucleoside diphosphate catabolic process (GO:0009134)2.49509857
126fertilization (GO:0009566)2.48756936
127ribosomal large subunit biogenesis (GO:0042273)2.48678188
128nonmotile primary cilium assembly (GO:0035058)2.47915302
129female gonad development (GO:0008585)2.46456616
130neuron cell-cell adhesion (GO:0007158)2.44551300
131GPI anchor metabolic process (GO:0006505)2.44195700
132preassembly of GPI anchor in ER membrane (GO:0016254)2.44119820
133meiosis I (GO:0007127)2.43942261
134diol metabolic process (GO:0034311)2.43748980
135meiotic cell cycle (GO:0051321)2.42532358
136limb bud formation (GO:0060174)2.42173195
137developmental pigmentation (GO:0048066)2.41271941
138organic cation transport (GO:0015695)2.40597289
139single strand break repair (GO:0000012)2.39679111
140regulation of mRNA 3-end processing (GO:0031440)2.39107999
141tryptophan catabolic process (GO:0006569)2.38561963
142indole-containing compound catabolic process (GO:0042436)2.38561963
143indolalkylamine catabolic process (GO:0046218)2.38561963
144cullin deneddylation (GO:0010388)2.38013942
145tolerance induction (GO:0002507)2.33620507
146protein neddylation (GO:0045116)2.33452432
147regulation of development, heterochronic (GO:0040034)2.33389416
148left/right axis specification (GO:0070986)2.33232381
149photoreceptor cell differentiation (GO:0046530)2.33160825
150eye photoreceptor cell differentiation (GO:0001754)2.33160825
151meiotic nuclear division (GO:0007126)2.32940308
152pyrimidine ribonucleoside catabolic process (GO:0046133)2.32837004
153DNA double-strand break processing (GO:0000729)2.32387980
154CTP biosynthetic process (GO:0006241)2.32319153
155CTP metabolic process (GO:0046036)2.32319153
156intra-Golgi vesicle-mediated transport (GO:0006891)2.30225014
157RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.29760883
158positive regulation of interleukin-1 secretion (GO:0050716)2.29088552
159protein deneddylation (GO:0000338)2.28593362
160intracellular pH reduction (GO:0051452)2.28463363
161vitamin biosynthetic process (GO:0009110)2.26815721
162cilium morphogenesis (GO:0060271)2.26724946
163beta-amyloid metabolic process (GO:0050435)2.25763610
164reciprocal meiotic recombination (GO:0007131)2.25745200
165reciprocal DNA recombination (GO:0035825)2.25745200
166organelle disassembly (GO:1903008)2.25660393
167spermatogenesis (GO:0007283)2.25505901
168male gamete generation (GO:0048232)2.24944447
169calcium ion import (GO:0070509)2.24737683
170positive regulation of mRNA 3-end processing (GO:0031442)2.24603428
171startle response (GO:0001964)2.24291548
172lymphoid progenitor cell differentiation (GO:0002320)2.23852315
173guanosine-containing compound biosynthetic process (GO:1901070)2.23604164
174indolalkylamine metabolic process (GO:0006586)2.21453088
175G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.20979395
176protein polyglutamylation (GO:0018095)2.20212083
177C-terminal protein amino acid modification (GO:0018410)2.19521894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.77583514
2EZH2_22144423_ChIP-Seq_EOC_Human4.06354379
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.49480483
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.10083962
5GBX2_23144817_ChIP-Seq_PC3_Human2.92758522
6* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87043393
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.84736756
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.84487274
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.74493803
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70113966
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67935851
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62057276
13VDR_22108803_ChIP-Seq_LS180_Human2.41997609
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.34471726
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.33776343
16ZNF274_21170338_ChIP-Seq_K562_Hela2.27761026
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26049673
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.24832155
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.22078841
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.15479049
21TAF15_26573619_Chip-Seq_HEK293_Human2.11950199
22PCGF2_27294783_Chip-Seq_NPCs_Mouse2.09961437
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03582290
24VDR_23849224_ChIP-Seq_CD4+_Human1.93713253
25EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.93654963
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.92683416
27TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.89521638
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.88367598
29P53_22387025_ChIP-Seq_ESCs_Mouse1.85407211
30SUZ12_18555785_Chip-Seq_ESCs_Mouse1.82470743
31EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.80207852
32P300_18555785_Chip-Seq_ESCs_Mouse1.79155193
33RNF2_27304074_Chip-Seq_NSC_Mouse1.78631765
34STAT3_18555785_Chip-Seq_ESCs_Mouse1.78239483
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.76133573
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74784577
37IGF1R_20145208_ChIP-Seq_DFB_Human1.74755016
38NMYC_18555785_Chip-Seq_ESCs_Mouse1.70975380
39CMYC_18555785_Chip-Seq_ESCs_Mouse1.68357062
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68072559
41RUNX1_27457419_Chip-Seq_LIVER_Mouse1.67610304
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66024689
43OCT4_18555785_Chip-Seq_ESCs_Mouse1.63427697
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.63248646
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63095068
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61299599
47FUS_26573619_Chip-Seq_HEK293_Human1.59956872
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59295718
49KLF4_18555785_Chip-Seq_ESCs_Mouse1.59280730
50ELK1_19687146_ChIP-ChIP_HELA_Human1.59136879
51* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.57014365
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56711485
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.56528261
54ZFX_18555785_Chip-Seq_ESCs_Mouse1.56487632
55ESRRB_18555785_Chip-Seq_ESCs_Mouse1.50088153
56IRF1_19129219_ChIP-ChIP_H3396_Human1.49839131
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.49616928
58P300_19829295_ChIP-Seq_ESCs_Human1.48785623
59SOX2_19829295_ChIP-Seq_ESCs_Human1.48374600
60NANOG_19829295_ChIP-Seq_ESCs_Human1.48374600
61PU1_27457419_Chip-Seq_LIVER_Mouse1.47159281
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.46646193
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46643864
64ER_23166858_ChIP-Seq_MCF-7_Human1.46379948
65GATA3_26560356_Chip-Seq_TH2_Human1.45394722
66SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43738954
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.43143443
68TP53_22573176_ChIP-Seq_HFKS_Human1.42171453
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41741154
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40784002
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.40341310
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38106604
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.38106604
74CTCF_18555785_Chip-Seq_ESCs_Mouse1.37970943
75BCAT_22108803_ChIP-Seq_LS180_Human1.36683098
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35468220
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.33893051
78AR_20517297_ChIP-Seq_VCAP_Human1.33580519
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.33200645
80HTT_18923047_ChIP-ChIP_STHdh_Human1.31352905
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30329704
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30235810
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29706053
84MYC_18940864_ChIP-ChIP_HL60_Human1.29589566
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29221837
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28417205
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28301594
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26090118
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25692149
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25381193
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.25171928
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23105057
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22946963
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22307985
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20101352
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19419373
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17996669
98TCF4_22108803_ChIP-Seq_LS180_Human1.16794301
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16387701
100RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15813980
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15489056
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15232110
103CDX2_22108803_ChIP-Seq_LS180_Human1.14894775
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14388055
105EWS_26573619_Chip-Seq_HEK293_Human1.13145137
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.12189025
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.11567984
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11237982
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11237982
110FOXP3_21729870_ChIP-Seq_TREG_Human1.11130588
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10750620
112SMAD4_21799915_ChIP-Seq_A2780_Human1.10623590
113CBP_20019798_ChIP-Seq_JUKART_Human1.09783727
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09783727
115KDM2B_26808549_Chip-Seq_REH_Human1.09782521
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09590944
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.09567226
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.09269047
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09181026
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07914369
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07815047
122CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06642787
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05659570
124SALL1_21062744_ChIP-ChIP_HESCs_Human1.05535453
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05470867
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05018381
127HOXB7_26014856_ChIP-Seq_BT474_Human1.04617476
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04120946
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03843145
130GATA3_26560356_Chip-Seq_TH1_Human1.03771246
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02272775
132RBPJ_21746931_ChIP-Seq_IB4_Human1.02013309
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.01892643
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01648023
135PHF8_20622853_ChIP-Seq_HELA_Human1.01385091
136ETV1_20927104_ChIP-Seq_GIST48_Human1.01035712
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00169226
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00010716
139KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99839317
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99709195
141FOXH1_21741376_ChIP-Seq_EPCs_Human0.98189539
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97787617
143LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95731535
144SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95343768
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.94008554
146TCF4_23295773_ChIP-Seq_U87_Human0.93891028
147RNF2_27304074_Chip-Seq_ESCs_Mouse0.93173659
148STAT1_17558387_ChIP-Seq_HELA_Human0.92419627
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91549051
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91442004
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.90131317
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89326596
153RUNX2_22187159_ChIP-Seq_PCA_Human0.88806236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.15254457
2MP0005410_abnormal_fertilization4.02283747
3MP0001188_hyperpigmentation3.59965063
4MP0003880_abnormal_central_pattern3.20438396
5MP0006292_abnormal_olfactory_placode3.17301958
6MP0003195_calcinosis3.10397021
7MP0000566_synostosis3.07077488
8MP0005084_abnormal_gallbladder_morpholo2.87227914
9MP0005409_darkened_coat_color2.86236176
10MP0009379_abnormal_foot_pigmentation2.77025138
11MP0002837_dystrophic_cardiac_calcinosis2.67210651
12MP0004043_abnormal_pH_regulation2.65022959
13MP0004381_abnormal_hair_follicle2.58713219
14MP0002138_abnormal_hepatobiliary_system2.45408683
15MP0008877_abnormal_DNA_methylation2.34061915
16MP0002102_abnormal_ear_morphology2.21859269
17MP0000685_abnormal_immune_system2.18920562
18MP0003806_abnormal_nucleotide_metabolis2.14900513
19MP0006036_abnormal_mitochondrial_physio2.06536086
20MP0002638_abnormal_pupillary_reflex2.01377589
21MP0008875_abnormal_xenobiotic_pharmacok2.00667305
22MP0001986_abnormal_taste_sensitivity1.98534626
23MP0008057_abnormal_DNA_replication1.98182353
24MP0005171_absent_coat_pigmentation1.92146851
25MP0003698_abnormal_male_reproductive1.90701691
26MP0000015_abnormal_ear_pigmentation1.89232922
27MP0001764_abnormal_homeostasis1.77038864
28MP0001929_abnormal_gametogenesis1.75017376
29MP0008995_early_reproductive_senescence1.74249506
30MP0006276_abnormal_autonomic_nervous1.71272855
31MP0004742_abnormal_vestibular_system1.68485376
32MP0008872_abnormal_physiological_respon1.66682175
33MP0002277_abnormal_respiratory_mucosa1.66502393
34MP0005423_abnormal_somatic_nervous1.60858931
35MP0002210_abnormal_sex_determination1.59441434
36MP0002148_abnormal_hypersensitivity_rea1.58705059
37MP0000569_abnormal_digit_pigmentation1.56299818
38MP0003941_abnormal_skin_development1.55932817
39MP0004019_abnormal_vitamin_homeostasis1.51986770
40MP0005645_abnormal_hypothalamus_physiol1.51550324
41MP0002163_abnormal_gland_morphology1.51229942
42MP0005174_abnormal_tail_pigmentation1.50245087
43MP0005389_reproductive_system_phenotype1.49657754
44MP0005379_endocrine/exocrine_gland_phen1.49590733
45MP0001800_abnormal_humoral_immune1.49112729
46MP0005365_abnormal_bile_salt1.48174189
47MP0000372_irregular_coat_pigmentation1.45823815
48MP0002132_abnormal_respiratory_system1.44007339
49MP0008058_abnormal_DNA_repair1.42764749
50MP0003724_increased_susceptibility_to1.39133670
51MP0001905_abnormal_dopamine_level1.38574190
52MP0003786_premature_aging1.38141332
53MP0001501_abnormal_sleep_pattern1.36339444
54MP0005646_abnormal_pituitary_gland1.35231026
55MP0002723_abnormal_immune_serum1.34529458
56MP0001529_abnormal_vocalization1.33634320
57MP0002693_abnormal_pancreas_physiology1.32840625
58MP0004215_abnormal_myocardial_fiber1.31674261
59MP0001919_abnormal_reproductive_system1.27521285
60MP0001968_abnormal_touch/_nociception1.27064690
61MP0005332_abnormal_amino_acid1.26032372
62MP0005464_abnormal_platelet_physiology1.25872490
63MP0000026_abnormal_inner_ear1.25581666
64MP0001486_abnormal_startle_reflex1.22803501
65MP0002452_abnormal_antigen_presenting1.22657502
66MP0008260_abnormal_autophagy1.20623579
67MP0010386_abnormal_urinary_bladder1.20094236
68MP0002909_abnormal_adrenal_gland1.18860220
69MP0009764_decreased_sensitivity_to1.18701583
70MP0003938_abnormal_ear_development1.17236515
71MP0002736_abnormal_nociception_after1.16616464
72MP0002095_abnormal_skin_pigmentation1.16604798
73MP0005551_abnormal_eye_electrophysiolog1.14487916
74MP0001984_abnormal_olfaction1.12603851
75MP0005085_abnormal_gallbladder_physiolo1.12041392
76MP0001145_abnormal_male_reproductive1.12012608
77MP0005636_abnormal_mineral_homeostasis1.12008521
78MP0001819_abnormal_immune_cell1.11723904
79MP0001765_abnormal_ion_homeostasis1.11547832
80MP0002420_abnormal_adaptive_immunity1.10342772
81MP0004142_abnormal_muscle_tone1.10240916
82MP0002876_abnormal_thyroid_physiology1.10035078
83MP0003436_decreased_susceptibility_to1.09960018
84MP0001845_abnormal_inflammatory_respons1.09318229
85MP0000049_abnormal_middle_ear1.08572728
86MP0000631_abnormal_neuroendocrine_gland1.06260456
87MP0002254_reproductive_system_inflammat1.05113042
88MP0002938_white_spotting1.04787162
89MP0000778_abnormal_nervous_system1.03804193
90MP0001835_abnormal_antigen_presentation1.03449256
91MP0006035_abnormal_mitochondrial_morpho1.03431422
92MP0003186_abnormal_redox_activity1.03121724
93MP0000653_abnormal_sex_gland1.02930372
94MP0009046_muscle_twitch1.02765971
95MP0005671_abnormal_response_to1.02002432
96MP0002160_abnormal_reproductive_system1.01545270
97MP0005075_abnormal_melanosome_morpholog1.00802489
98MP0001853_heart_inflammation0.99300908
99MP0005253_abnormal_eye_physiology0.97885975
100MP0010155_abnormal_intestine_physiology0.97712370
101MP0002928_abnormal_bile_duct0.97577503
102MP0003315_abnormal_perineum_morphology0.97321019
103MP0001944_abnormal_pancreas_morphology0.96253065
104MP0009745_abnormal_behavioral_response0.96021306
105MP0002090_abnormal_vision0.95423166
106MP0009780_abnormal_chondrocyte_physiolo0.95264090
107MP0008469_abnormal_protein_level0.94178529
108MP0001756_abnormal_urination0.93879378
109MP0003252_abnormal_bile_duct0.93841729
110MP0002067_abnormal_sensory_capabilities0.92752343
111MP0003718_maternal_effect0.91945632
112MP0002272_abnormal_nervous_system0.91944706
113MP0010329_abnormal_lipoprotein_level0.91434850
114MP0008873_increased_physiological_sensi0.90790983
115MP0002177_abnormal_outer_ear0.90771010
116MP0000689_abnormal_spleen_morphology0.90521782
117MP0002139_abnormal_hepatobiliary_system0.90372102
118MP0001963_abnormal_hearing_physiology0.89838008
119MP0001502_abnormal_circadian_rhythm0.89192073
120MP0009785_altered_susceptibility_to0.89000872
121MP0000230_abnormal_systemic_arterial0.88552376
122MP0002161_abnormal_fertility/fecundity0.87439864
123MP0006072_abnormal_retinal_apoptosis0.87416918
124MP0003787_abnormal_imprinting0.86073351
125MP0001542_abnormal_bone_strength0.84863079
126MP0003011_delayed_dark_adaptation0.84823304
127MP0001485_abnormal_pinna_reflex0.84428652
128MP0005367_renal/urinary_system_phenotyp0.83594774
129MP0000516_abnormal_urinary_system0.83594774
130MP0002419_abnormal_innate_immunity0.83312718
131MP0002572_abnormal_emotion/affect_behav0.81663197
132MP0002249_abnormal_larynx_morphology0.80316463
133MP0005310_abnormal_salivary_gland0.79426775
134MP0002557_abnormal_social/conspecific_i0.78293289
135MP0002751_abnormal_autonomic_nervous0.77969683
136MP0001346_abnormal_lacrimal_gland0.77464307
137MP0000716_abnormal_immune_system0.77394397
138MP0006082_CNS_inflammation0.77249908
139MP0000427_abnormal_hair_cycle0.76572235
140MP0000681_abnormal_thyroid_gland0.76086284
141MP0005000_abnormal_immune_tolerance0.76039545
142MP0000613_abnormal_salivary_gland0.75515589
143MP0002752_abnormal_somatic_nervous0.75167961
144MP0008789_abnormal_olfactory_epithelium0.73332826
145MP0008004_abnormal_stomach_pH0.72193519
146MP0005257_abnormal_intraocular_pressure0.71698261
147MP0005025_abnormal_response_to0.71167798
148MP0009250_abnormal_appendicular_skeleto0.70290613
149MP0008007_abnormal_cellular_replicative0.69524504
150MP0000383_abnormal_hair_follicle0.69385866
151MP0000920_abnormal_myelination0.68380413
152MP0002735_abnormal_chemical_nociception0.68135298
153MP0000647_abnormal_sebaceous_gland0.68085008
154MP0002064_seizures0.68081884
155MP0005451_abnormal_body_composition0.67798014
156MP0001790_abnormal_immune_system0.65408800
157MP0005387_immune_system_phenotype0.65408800
158MP0001440_abnormal_grooming_behavior0.64669396
159MP0003763_abnormal_thymus_physiology0.64506550

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.12659405
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.84061884
3Absent/shortened dynein arms (HP:0200106)5.84061884
4Congenital stationary night blindness (HP:0007642)5.29341307
5Abnormal respiratory epithelium morphology (HP:0012253)4.80802871
6Abnormal respiratory motile cilium morphology (HP:0005938)4.80802871
7Abnormal respiratory motile cilium physiology (HP:0012261)4.70368290
8Abnormal ciliary motility (HP:0012262)4.46895094
9Severe visual impairment (HP:0001141)4.34540072
10Abnormality of macular pigmentation (HP:0008002)3.86372817
11Abnormal rod and cone electroretinograms (HP:0008323)3.84177297
12Rhinitis (HP:0012384)3.61764963
13Renal cortical cysts (HP:0000803)3.61412035
14Abnormality of the fovea (HP:0000493)3.50855092
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38738859
16Albinism (HP:0001022)3.37428350
17Central scotoma (HP:0000603)3.33847335
18Generalized aminoaciduria (HP:0002909)3.27935171
19Duplicated collecting system (HP:0000081)3.25085532
20Abnormality of the renal cortex (HP:0011035)3.17148282
21Nephronophthisis (HP:0000090)3.09207824
22Medial flaring of the eyebrow (HP:0010747)3.07961388
23Progressive macrocephaly (HP:0004481)3.00561335
24Abnormality of the renal collecting system (HP:0004742)2.98549018
25Chronic hepatic failure (HP:0100626)2.93469256
26Chromsome breakage (HP:0040012)2.92959914
27Hepatic necrosis (HP:0002605)2.85520318
28Abnormality of urine glucose concentration (HP:0011016)2.84627401
29Glycosuria (HP:0003076)2.84627401
30Increased CSF lactate (HP:0002490)2.84390922
31Parakeratosis (HP:0001036)2.72431122
32Congenital, generalized hypertrichosis (HP:0004540)2.69089437
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.68645379
34Abnormal mitochondria in muscle tissue (HP:0008316)2.65646277
35Methylmalonic acidemia (HP:0002912)2.65158134
36Hypoglycemic coma (HP:0001325)2.63742668
37Abnormality of the renal medulla (HP:0100957)2.56015254
38Aplasia/Hypoplasia of the macula (HP:0008059)2.55885342
39True hermaphroditism (HP:0010459)2.55873213
40Acute encephalopathy (HP:0006846)2.53756841
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47823034
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47823034
43Tubulointerstitial nephritis (HP:0001970)2.45822584
44Reticulocytopenia (HP:0001896)2.35146736
45Aplasia/Hypoplasia affecting the retina (HP:0008061)2.34681046
46Lipid accumulation in hepatocytes (HP:0006561)2.34601119
47Scotoma (HP:0000575)2.33901039
48Chronic bronchitis (HP:0004469)2.32150615
49Methylmalonic aciduria (HP:0012120)2.25291896
50Molar tooth sign on MRI (HP:0002419)2.23778341
51Abnormality of midbrain morphology (HP:0002418)2.23778341
52Pancreatic cysts (HP:0001737)2.23695262
53Abnormality of vitamin B metabolism (HP:0004340)2.23395161
54Hepatocellular necrosis (HP:0001404)2.23338346
55Septo-optic dysplasia (HP:0100842)2.21713227
56Nephrogenic diabetes insipidus (HP:0009806)2.21683400
57Abnormality of the axillary hair (HP:0100134)2.20568488
58Abnormality of secondary sexual hair (HP:0009888)2.20568488
59Abnormality of the septum pellucidum (HP:0007375)2.17686896
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17351729
61Congenital sensorineural hearing impairment (HP:0008527)2.16321330
62Renal Fanconi syndrome (HP:0001994)2.15116398
63Congenital primary aphakia (HP:0007707)2.14793382
64Type I transferrin isoform profile (HP:0003642)2.13550758
65Nausea (HP:0002018)2.13405617
66Abnormality of renal resorption (HP:0011038)2.12717692
67Gait imbalance (HP:0002141)2.12248536
68Chronic obstructive pulmonary disease (HP:0006510)2.10777085
69Obstructive lung disease (HP:0006536)2.10777085
70Bronchiectasis (HP:0002110)2.10514267
713-Methylglutaconic aciduria (HP:0003535)2.10002292
72Optic nerve hypoplasia (HP:0000609)2.09928826
73Abnormal drinking behavior (HP:0030082)2.09319290
74Polydipsia (HP:0001959)2.09319290
75Pancreatic fibrosis (HP:0100732)2.08612385
76Duplication of thumb phalanx (HP:0009942)2.08265846
77Hypothermia (HP:0002045)2.08126485
78Increased hepatocellular lipid droplets (HP:0006565)2.07185864
79IgG deficiency (HP:0004315)2.06844872
80Absent septum pellucidum (HP:0001331)2.02768399
81Aplasia/Hypoplasia of the tibia (HP:0005772)2.02162873
82Abolished electroretinogram (ERG) (HP:0000550)2.01406577
83Stomatitis (HP:0010280)2.00548915
84Abnormal spermatogenesis (HP:0008669)2.00190036
85Supernumerary spleens (HP:0009799)1.98773928
86Azoospermia (HP:0000027)1.97994518
87Conical tooth (HP:0000698)1.96448043
88Degeneration of anterior horn cells (HP:0002398)1.96256148
89Abnormality of the anterior horn cell (HP:0006802)1.96256148
90Abnormality of the preputium (HP:0100587)1.96010617
91Cerebral edema (HP:0002181)1.95986526
92Hypomagnesemia (HP:0002917)1.95390272
93Meckel diverticulum (HP:0002245)1.94662921
94Prostate neoplasm (HP:0100787)1.92375653
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91624811
96Male pseudohermaphroditism (HP:0000037)1.91430243
97Infertility (HP:0000789)1.91184632
98Abnormality of methionine metabolism (HP:0010901)1.90634181
99Triphalangeal thumb (HP:0001199)1.88785203
100Increased serum lactate (HP:0002151)1.88296535
101Aplasia/Hypoplasia of the lens (HP:0008063)1.87986163
102Nephroblastoma (Wilms tumor) (HP:0002667)1.87954706
103Tongue fasciculations (HP:0001308)1.86696957
104Furrowed tongue (HP:0000221)1.86306644
105Abnormality of the ileum (HP:0001549)1.85965095
106Preaxial hand polydactyly (HP:0001177)1.85147386
107Clubbing of toes (HP:0100760)1.85101656
108Patchy hypopigmentation of hair (HP:0011365)1.85055357
109Aplasia/hypoplasia of the uterus (HP:0008684)1.85049042
110Proximal tubulopathy (HP:0000114)1.84787171
111Postaxial foot polydactyly (HP:0001830)1.84677719
112Lactic acidosis (HP:0003128)1.84398567
113Optic disc pallor (HP:0000543)1.83604122
114White forelock (HP:0002211)1.83567102
115Ectopic kidney (HP:0000086)1.82349681
116Retrobulbar optic neuritis (HP:0100654)1.82133358
117Optic neuritis (HP:0100653)1.82133358
118Ketosis (HP:0001946)1.80489756
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79212073
120Abnormality of alanine metabolism (HP:0010916)1.79212073
121Hyperalaninemia (HP:0003348)1.79212073
122Respiratory failure (HP:0002878)1.79107331
123Mitochondrial inheritance (HP:0001427)1.78932390
124Short tibia (HP:0005736)1.78901102
125Abnormality of the vitamin B12 metabolism (HP:0004341)1.78208112
126Acute necrotizing encephalopathy (HP:0006965)1.77236870
127Abnormality of molar (HP:0011077)1.77035210
128Abnormality of molar morphology (HP:0011070)1.77035210
129Embryonal renal neoplasm (HP:0011794)1.76401230
130Attenuation of retinal blood vessels (HP:0007843)1.76159799
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.75796692
132Dyschromatopsia (HP:0007641)1.75140694
133Petechiae (HP:0000967)1.74032966
134Tubular atrophy (HP:0000092)1.73370553
135Exertional dyspnea (HP:0002875)1.73351546
136Aplasia/Hypoplasia of the fovea (HP:0008060)1.72774942
137Hypoplasia of the fovea (HP:0007750)1.72774942
138Concave nail (HP:0001598)1.72657463
139Median cleft lip (HP:0000161)1.71958009
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71585016
141Vascular calcification (HP:0004934)1.71461547
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70913025
143Febrile seizures (HP:0002373)1.70614200
144Pallor (HP:0000980)1.70086449
145Sex reversal (HP:0012245)1.69983171
146Abnormal sex determination (HP:0012244)1.69983171
147Congenital hepatic fibrosis (HP:0002612)1.69558666
148Constricted visual fields (HP:0001133)1.69078730
149Recurrent sinusitis (HP:0011108)1.68921680
150Aganglionic megacolon (HP:0002251)1.68703710
151Lethargy (HP:0001254)1.68337512
152Vaginal atresia (HP:0000148)1.67563906
153Chronic sinusitis (HP:0011109)1.66850523
154Genital tract atresia (HP:0001827)1.65850300
155Decreased central vision (HP:0007663)1.64999964
156Dry hair (HP:0011359)1.63960398
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.62175943
158Dicarboxylic aciduria (HP:0003215)1.62175943
159Macrocytic anemia (HP:0001972)1.60894459
160Abnormality of the dental root (HP:0006486)1.60464823
161Taurodontia (HP:0000679)1.60464823
162Abnormality of permanent molar morphology (HP:0011071)1.60464823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.07501844
2MAPKAPK34.83755733
3CASK3.65998639
4TNIK3.00110789
5TAOK32.95953137
6STK162.65285290
7TLK12.56726715
8ACVR1B2.51241362
9IRAK42.28947854
10MKNK22.20967037
11SRPK12.15500435
12MAP4K22.07976070
13BMPR22.07271668
14IRAK32.00745500
15BLK1.90426202
16PBK1.88245650
17BMPR1B1.86008441
18STK391.84864379
19YES11.78613480
20STK241.76082173
21IRAK11.74753481
22IRAK21.67074214
23TXK1.65520837
24PRPF4B1.63110295
25MAP2K71.59656545
26MAP3K141.55439066
27MKNK11.52361457
28NEK61.51607647
29ADRBK21.49176743
30DAPK11.46211460
31EIF2AK21.43559216
32NUAK11.43142071
33NME21.42687838
34RIPK41.39510448
35PDK31.39066390
36PDK41.39066390
37GRK11.37004134
38GRK71.35147634
39TRPM71.30022798
40PHKG21.29673366
41PHKG11.29673366
42CLK11.29023696
43VRK11.28711168
44INSRR1.27924704
45CDK31.26876889
46MAPK131.26241563
47PDK21.26058331
48PNCK1.24711634
49MUSK1.21907114
50PAK31.16210426
51CAMKK21.12912367
52PLK41.12845044
53MAPKAPK51.11484059
54MST41.11423428
55ZAK1.11196442
56MAPK151.08838203
57WNK41.00709983
58FES0.99387731
59MYLK0.97934832
60GRK60.97390742
61CSNK1G10.97375791
62PKN10.93496230
63NLK0.91362985
64TRIM280.90475484
65CSNK1G30.89960155
66OXSR10.86048932
67NME10.85121929
68EIF2AK30.83926000
69MAP3K120.82080124
70CSF1R0.81705540
71STK30.81419739
72CSNK1G20.81398390
73TEC0.77641859
74DAPK20.77287638
75BUB10.72275349
76IKBKB0.71589101
77CDK80.69517998
78AKT30.68639539
79DYRK20.68523738
80DYRK1A0.67671063
81DYRK30.66968295
82GRK50.66767907
83EPHA40.66700011
84EIF2AK10.66109708
85ITK0.66107110
86PRKD20.65886247
87RPS6KA50.62788838
88MAPK70.62108362
89TIE10.62084645
90ZAP700.62008420
91CAMK2B0.61675186
92PLK30.61664293
93BRAF0.61635029
94MAP2K60.60037890
95PASK0.59629187
96BRD40.58493819
97PRKCE0.57781231
98BCR0.57125457
99PINK10.56342156
100WNK30.56018860
101LYN0.54794730
102CHUK0.52248657
103IKBKE0.52161750
104PRKCG0.52044151
105EPHB20.51543446
106ADRBK10.51487427
107UHMK10.51014370
108BRSK20.49971579
109CAMK2A0.49857140
110CSNK1A1L0.48582154
111PIM20.46635537
112NTRK30.46428138
113TGFBR10.46113283
114LCK0.45624664
115ERBB30.43753682
116CDK90.43018561
117MAP3K50.42991996
118MARK30.42698805
119CAMK2D0.42679956
120BTK0.42661564
121PLK20.41593995
122PRKCQ0.39635073
123SIK30.38479132
124TESK10.38210881
125MAP3K40.37925216
126TNK20.37704042
127BCKDK0.37149423
128STK38L0.36858924
129WNK10.36809207
130SGK20.36771300
131PTK2B0.35029886
132PRKG10.34251097
133FGR0.34188706
134PRKACA0.33725337
135CHEK20.33501893
136JAK10.33298835
137AURKA0.32968960
138TESK20.32417773
139PRKCI0.31543888
140SYK0.31524089
141IGF1R0.31287892
142CSNK2A10.31287732
143PLK10.31274729
144VRK20.30825850
145CCNB10.30149189
146PIK3CG0.29671413

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.96668420
2Fanconi anemia pathway_Homo sapiens_hsa034602.71873076
3Protein export_Homo sapiens_hsa030602.42187313
4Homologous recombination_Homo sapiens_hsa034402.41188463
5Oxidative phosphorylation_Homo sapiens_hsa001902.35379314
6RNA polymerase_Homo sapiens_hsa030202.25853131
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.20029142
8Basal transcription factors_Homo sapiens_hsa030222.16037228
9Graft-versus-host disease_Homo sapiens_hsa053322.14336134
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95016926
11Sphingolipid metabolism_Homo sapiens_hsa006001.92256516
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84961830
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83323528
14Huntingtons disease_Homo sapiens_hsa050161.80015934
15Arachidonic acid metabolism_Homo sapiens_hsa005901.73332402
16Phototransduction_Homo sapiens_hsa047441.70717393
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66919029
18Parkinsons disease_Homo sapiens_hsa050121.64843956
19Nicotine addiction_Homo sapiens_hsa050331.63085850
20Caffeine metabolism_Homo sapiens_hsa002321.59817696
21Ether lipid metabolism_Homo sapiens_hsa005651.57710647
22Nitrogen metabolism_Homo sapiens_hsa009101.55116516
23Allograft rejection_Homo sapiens_hsa053301.54402620
24Selenocompound metabolism_Homo sapiens_hsa004501.53089583
25Autoimmune thyroid disease_Homo sapiens_hsa053201.51815909
26Alzheimers disease_Homo sapiens_hsa050101.47733080
27Non-homologous end-joining_Homo sapiens_hsa034501.46295503
28Pyrimidine metabolism_Homo sapiens_hsa002401.33837694
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31456123
30Rheumatoid arthritis_Homo sapiens_hsa053231.29819892
31Linoleic acid metabolism_Homo sapiens_hsa005911.25511666
32One carbon pool by folate_Homo sapiens_hsa006701.23218309
33Asthma_Homo sapiens_hsa053101.20128580
34Primary immunodeficiency_Homo sapiens_hsa053401.19803784
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18271406
36Chemical carcinogenesis_Homo sapiens_hsa052041.17319267
37Proteasome_Homo sapiens_hsa030501.16267902
38Vitamin B6 metabolism_Homo sapiens_hsa007501.15454285
39Taste transduction_Homo sapiens_hsa047421.14582060
40Serotonergic synapse_Homo sapiens_hsa047261.14299705
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.12461977
42Purine metabolism_Homo sapiens_hsa002301.09047552
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07594392
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03570070
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03437879
46Spliceosome_Homo sapiens_hsa030401.02280983
47Antigen processing and presentation_Homo sapiens_hsa046121.00669495
48Hematopoietic cell lineage_Homo sapiens_hsa046401.00290938
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99323259
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99232624
51Nucleotide excision repair_Homo sapiens_hsa034200.99049589
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97330111
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.95650902
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.95268317
55Mismatch repair_Homo sapiens_hsa034300.95239068
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95138886
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95086494
58beta-Alanine metabolism_Homo sapiens_hsa004100.94954830
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94859077
60RNA degradation_Homo sapiens_hsa030180.94851292
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94399830
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92228133
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92153410
64Butanoate metabolism_Homo sapiens_hsa006500.90070737
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89117550
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88201272
67Tryptophan metabolism_Homo sapiens_hsa003800.85164274
68Peroxisome_Homo sapiens_hsa041460.84680033
69Collecting duct acid secretion_Homo sapiens_hsa049660.84391705
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83891718
71Measles_Homo sapiens_hsa051620.81491803
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81425928
73Other glycan degradation_Homo sapiens_hsa005110.81305559
74Retinol metabolism_Homo sapiens_hsa008300.81122702
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79376616
76Morphine addiction_Homo sapiens_hsa050320.78999179
77DNA replication_Homo sapiens_hsa030300.77475823
78Type I diabetes mellitus_Homo sapiens_hsa049400.72242652
79Glutamatergic synapse_Homo sapiens_hsa047240.71549758
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70179449
81Staphylococcus aureus infection_Homo sapiens_hsa051500.69868890
82Regulation of autophagy_Homo sapiens_hsa041400.69608648
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69252971
84Base excision repair_Homo sapiens_hsa034100.68177511
85Vitamin digestion and absorption_Homo sapiens_hsa049770.67379407
86African trypanosomiasis_Homo sapiens_hsa051430.67115074
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66786879
88Steroid biosynthesis_Homo sapiens_hsa001000.66357008
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65291441
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64737379
91Cardiac muscle contraction_Homo sapiens_hsa042600.63771466
92Malaria_Homo sapiens_hsa051440.62836924
93Phagosome_Homo sapiens_hsa041450.62385907
94Axon guidance_Homo sapiens_hsa043600.61929355
95mRNA surveillance pathway_Homo sapiens_hsa030150.60544269
96Herpes simplex infection_Homo sapiens_hsa051680.60194598
97Propanoate metabolism_Homo sapiens_hsa006400.59896396
98Calcium signaling pathway_Homo sapiens_hsa040200.58023707
99Amphetamine addiction_Homo sapiens_hsa050310.57628957
100Glutathione metabolism_Homo sapiens_hsa004800.55653607
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53513090
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52739929
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52006653
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51815655
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.51043159
106Histidine metabolism_Homo sapiens_hsa003400.50725325
107Insulin secretion_Homo sapiens_hsa049110.50479518
108Fatty acid elongation_Homo sapiens_hsa000620.48495526
109Folate biosynthesis_Homo sapiens_hsa007900.46170225
110Long-term depression_Homo sapiens_hsa047300.46059547
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44510864
112Circadian rhythm_Homo sapiens_hsa047100.44416653
113Wnt signaling pathway_Homo sapiens_hsa043100.44254435
114Systemic lupus erythematosus_Homo sapiens_hsa053220.43629545
115Salmonella infection_Homo sapiens_hsa051320.43085326
116Legionellosis_Homo sapiens_hsa051340.42369993
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42282278
118Mineral absorption_Homo sapiens_hsa049780.41842807
119Lysosome_Homo sapiens_hsa041420.41816768
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39558051
121Renin secretion_Homo sapiens_hsa049240.38057949
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.35812523
123Olfactory transduction_Homo sapiens_hsa047400.35571087
124Circadian entrainment_Homo sapiens_hsa047130.35291354
125T cell receptor signaling pathway_Homo sapiens_hsa046600.35025297
126Leishmaniasis_Homo sapiens_hsa051400.34927954
127Pertussis_Homo sapiens_hsa051330.34906186
128Basal cell carcinoma_Homo sapiens_hsa052170.34814918
129Epstein-Barr virus infection_Homo sapiens_hsa051690.34557919
130Vibrio cholerae infection_Homo sapiens_hsa051100.34298879
131Fat digestion and absorption_Homo sapiens_hsa049750.32927132
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.32846950
133Metabolic pathways_Homo sapiens_hsa011000.32792736
134Chemokine signaling pathway_Homo sapiens_hsa040620.30397977
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30378916
136Sulfur metabolism_Homo sapiens_hsa009200.30210231
137RNA transport_Homo sapiens_hsa030130.29132789

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