ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of acrosome reaction (GO:0060046)	8.34346177
2	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.59065913
3	regulation of female gonad development (GO:2000194)	6.41654697
4	oocyte development (GO:0048599)	6.08020904
5	protein kinase C signaling (GO:0070528)	6.04070094
6	multicellular organism reproduction (GO:0032504)	5.99486017
7	protein carboxylation (GO:0018214)	5.41565816
8	peptidyl-glutamic acid carboxylation (GO:0017187)	5.41565816
9	GDP-mannose metabolic process (GO:0019673)	5.09990099
10	negative regulation of fatty acid transport (GO:2000192)	4.56402827
11	negative regulation of reproductive process (GO:2000242)	4.28504263
12	protein retention in ER lumen (GO:0006621)	4.21274360
13	positive regulation of humoral immune response (GO:0002922)	4.19120901
14	reproduction (GO:0000003)	4.17998678
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.10349370
16	L-phenylalanine metabolic process (GO:0006558)	4.10349370
17	regulation of phospholipid biosynthetic process (GO:0071071)	4.06882790
18	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.05001046
19	proline biosynthetic process (GO:0006561)	4.02783098
20	regulation of cholesterol homeostasis (GO:2000188)	3.88986859
21	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	3.85171792
22	binding of sperm to zona pellucida (GO:0007339)	3.81106978
23	exocrine pancreas development (GO:0031017)	3.80177337
24	proline metabolic process (GO:0006560)	3.75826438
25	regulation of DNA methylation (GO:0044030)	3.75619988
26	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.72155953
27	positive regulation of hormone metabolic process (GO:0032352)	3.71527433
28	regulation of cholesterol esterification (GO:0010872)	3.63463651
29	amyloid precursor protein catabolic process (GO:0042987)	3.61370434
30	endothelial cell chemotaxis (GO:0035767)	3.60298545
31	Golgi transport vesicle coating (GO:0048200)	3.54859912
32	COPI coating of Golgi vesicle (GO:0048205)	3.54859912
33	positive regulation of triglyceride lipase activity (GO:0061365)	3.46273871
34	positive regulation of lipoprotein lipase activity (GO:0051006)	3.46273871
35	regulation of cholesterol biosynthetic process (GO:0045540)	3.45805517
36	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.36945614
37	regulation of fatty acid beta-oxidation (GO:0031998)	3.32113996
38	L-phenylalanine catabolic process (GO:0006559)	3.28027207
39	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.28027207
40	citrulline biosynthetic process (GO:0019240)	3.27352312
41	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.25900171
42	negative regulation of cell size (GO:0045792)	3.19715881
43	regulation of bile acid biosynthetic process (GO:0070857)	3.19343202
44	positive regulation of cellular amine metabolic process (GO:0033240)	3.16365263
45	cell-cell junction maintenance (GO:0045217)	3.15517220
46	regulation of chromatin binding (GO:0035561)	3.13761195
47	urea cycle (GO:0000050)	3.08513443
48	sperm-egg recognition (GO:0035036)	3.05146282
49	phosphatidylethanolamine metabolic process (GO:0046337)	2.98978483
50	response to misfolded protein (GO:0051788)	2.96563418
51	regulation of fibrinolysis (GO:0051917)	2.96538636
52	biotin metabolic process (GO:0006768)	2.94480764
53	urea metabolic process (GO:0019627)	2.92334021
54	plasma lipoprotein particle assembly (GO:0034377)	2.91628976
55	DNA methylation involved in gamete generation (GO:0043046)	2.91338630
56	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.88995977
57	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.86061017
58	regulation of plasminogen activation (GO:0010755)	2.84119344
59	negative regulation of fibrinolysis (GO:0051918)	2.83651861
60	regulation of cholesterol metabolic process (GO:0090181)	2.82225883
61	virion assembly (GO:0019068)	2.82172823
62	peptidyl-glutamic acid modification (GO:0018200)	2.76176659
63	negative regulation of lipase activity (GO:0060192)	2.75341239
64	single fertilization (GO:0007338)	2.75155263
65	positive regulation of hormone biosynthetic process (GO:0046886)	2.74373899
66	positive regulation of reproductive process (GO:2000243)	2.74068939
67	negative regulation of histone methylation (GO:0031061)	2.72978260
68	viral protein processing (GO:0019082)	2.69500431
69	positive regulation of steroid metabolic process (GO:0045940)	2.68112853
70	mitotic chromosome condensation (GO:0007076)	2.67626268
71	intestinal epithelial cell development (GO:0060576)	2.67613836
72	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.67250001
73	cerebral cortex neuron differentiation (GO:0021895)	2.65639766
74	positive regulation of steroid biosynthetic process (GO:0010893)	2.64075363
75	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.64070783
76	myelin maintenance (GO:0043217)	2.62655420
77	mammary gland epithelial cell differentiation (GO:0060644)	2.61750514
78	nitrogen cycle metabolic process (GO:0071941)	2.61150289
79	negative regulation of lipid transport (GO:0032369)	2.60524810
80	amyloid precursor protein metabolic process (GO:0042982)	2.59754138
81	very-low-density lipoprotein particle assembly (GO:0034379)	2.58506594
82	phospholipid efflux (GO:0033700)	2.56965951
83	regulation of steroid hormone biosynthetic process (GO:0090030)	2.56038657
84	citrulline metabolic process (GO:0000052)	2.55126833
85	regulation of autophagic vacuole assembly (GO:2000785)	2.54463372
86	cellular zinc ion homeostasis (GO:0006882)	2.53285267
87	fertilization (GO:0009566)	2.51820900
88	meiotic cell cycle (GO:0051321)	2.51656855
89	activation of Rac GTPase activity (GO:0032863)	2.50707767
90	regulation of lipoprotein particle clearance (GO:0010984)	2.50542029
91	protein-lipid complex assembly (GO:0065005)	2.50030647
92	cell junction maintenance (GO:0034331)	2.49597765
93	nucleotide-sugar biosynthetic process (GO:0009226)	2.47834466
94	regulation of reproductive process (GO:2000241)	2.47833365
95	cholesterol efflux (GO:0033344)	2.47799330
96	ear development (GO:0043583)	2.47352461
97	histone H2B ubiquitination (GO:0033523)	2.46466067
98	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.46393355
99	focal adhesion assembly (GO:0048041)	2.46385451
100	cell-substrate adherens junction assembly (GO:0007045)	2.46385451

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.75833977
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.42888418
3	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.89512627
4	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.80043253
5	* ESR2_21235772_ChIP-Seq_MCF-7_Human	2.74711164
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.74658291
7	RACK7_27058665_Chip-Seq_MCF-7_Human	2.65275848
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.55551210
9	VDR_21846776_ChIP-Seq_THP-1_Human	2.29066958
10	* P68_20966046_ChIP-Seq_HELA_Human	2.24657290
11	ZNF263_19887448_ChIP-Seq_K562_Human	2.20255482
12	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.16102231
13	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.13122963
14	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.09930866
15	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.01124002
16	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.98307822
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.96385672
18	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.94517829
19	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.89742310
20	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.85719780
21	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.80595630
22	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.79799427
23	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.77445641
24	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.76954541
25	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.74820765
26	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.74086848
27	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.72701586
28	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.72138614
29	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.70649975
30	* SMC4_20622854_ChIP-Seq_HELA_Human	1.69848525
31	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.69365034
32	BCOR_27268052_Chip-Seq_Bcells_Human	1.68300009
33	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.68160724
34	TCF7_22412390_ChIP-Seq_EML_Mouse	1.67032494
35	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.65045586
36	KDM2B_26808549_Chip-Seq_DND41_Human	1.61997583
37	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.61632072
38	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.60622511
39	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.56856030
40	CREB1_26743006_Chip-Seq_LNCaP_Human	1.56697325
41	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.55505436
42	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.53614328
43	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.52997143
44	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.52826895
45	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.48451989
46	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.47558089
47	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.47262926
48	BCL6_27268052_Chip-Seq_Bcells_Human	1.46645558
49	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.46266908
50	CTCF_27219007_Chip-Seq_Bcells_Human	1.45280672
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44408710
52	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.40197716
53	KDM2B_26808549_Chip-Seq_K562_Human	1.40126624
54	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.36465237
55	CTCF_21964334_Chip-Seq_Bcells_Human	1.36244802
56	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.36195151
57	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.35945329
58	MYC_22102868_ChIP-Seq_BL_Human	1.34682045
59	E2F1_20622854_ChIP-Seq_HELA_Human	1.33900108
60	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.33500417
61	PHF8_20622854_ChIP-Seq_HELA_Human	1.32104479
62	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.30940939
63	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.30202188
64	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.28893411
65	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.28566359
66	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.27022791
67	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.24482278
68	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.23400659
69	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.23176479
70	* ATF3_27146783_Chip-Seq_COLON_Human	1.22868872
71	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.18699935
72	TP63_22573176_ChIP-Seq_HFKS_Human	1.17873339
73	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17529542
74	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.17291820
75	CTCF_20526341_ChIP-Seq_ESCs_Human	1.17236456
76	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.16766835
77	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.16678487
78	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.16467594
79	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.15330011
80	MAF_26560356_Chip-Seq_TH2_Human	1.14282265
81	* YY1_22570637_ChIP-Seq_MALME-3M_Human	1.13500434
82	TP53_22127205_ChIP-Seq_IMR90_Human	1.12580619
83	XRN2_22483619_ChIP-Seq_HELA_Human	1.11580274
84	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.10808937
85	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.09965114
86	OCT4_19829295_ChIP-Seq_ESCs_Human	1.05606116
87	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.05161879
88	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.05150092
89	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.03304803
90	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03089339
91	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.02061990
92	ERA_21632823_ChIP-Seq_H3396_Human	1.01946916
93	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.01659701
94	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.00735835
95	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.00276519
96	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.99833377
97	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.99332148
98	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.98065470
99	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.97715510
100	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.97662367

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	4.59194843
2	MP0002139_abnormal_hepatobiliary_system	3.81600267
3	MP0003718_maternal_effect	3.80662654
4	MP0009840_abnormal_foam_cell	3.44484324
5	MP0005377_hearing/vestibular/ear_phenot	3.29431092
6	MP0003878_abnormal_ear_physiology	3.29431092
7	MP0003136_yellow_coat_color	3.03787848
8	MP0004264_abnormal_extraembryonic_tissu	2.97840548
9	MP0003123_paternal_imprinting	2.89419116
10	MP0010234_abnormal_vibrissa_follicle	2.88948485
11	MP0005451_abnormal_body_composition	2.71734111
12	MP0003705_abnormal_hypodermis_morpholog	2.67668250
13	MP0005365_abnormal_bile_salt	2.49619785
14	MP0005409_darkened_coat_color	2.30749532
15	MP0003879_abnormal_hair_cell	2.30290829
16	MP0000566_synostosis	2.25609697
17	MP0002089_abnormal_postnatal_growth/wei	2.20746980
18	MP0005410_abnormal_fertilization	1.94170556
19	MP0010030_abnormal_orbit_morphology	1.93789365
20	MP0008875_abnormal_xenobiotic_pharmacok	1.90750678
21	MP0005257_abnormal_intraocular_pressure	1.86357882
22	MP0001666_abnormal_nutrient_absorption	1.79084345
23	MP0005395_other_phenotype	1.62879950
24	MP0004381_abnormal_hair_follicle	1.58943099
25	MP0003699_abnormal_female_reproductive	1.58033456
26	MP0005076_abnormal_cell_differentiation	1.57575048
27	MP0003191_abnormal_cellular_cholesterol	1.54740568
28	MP0008260_abnormal_autophagy	1.51024827
29	MP0002796_impaired_skin_barrier	1.47422671
30	MP0005085_abnormal_gallbladder_physiolo	1.44293331
31	MP0005058_abnormal_lysosome_morphology	1.34510908
32	MP0010329_abnormal_lipoprotein_level	1.32968336
33	MP0004185_abnormal_adipocyte_glucose	1.32339159
34	MP0001929_abnormal_gametogenesis	1.32070752
35	MP0005501_abnormal_skin_physiology	1.30661079
36	MP0009384_cardiac_valve_regurgitation	1.28332579
37	MP0002653_abnormal_ependyma_morphology	1.28072599
38	MP0010678_abnormal_skin_adnexa	1.27636736
39	MP0002822_catalepsy	1.27441798
40	MP0000383_abnormal_hair_follicle	1.26695707
41	MP0001664_abnormal_digestion	1.22250764
42	MP0002161_abnormal_fertility/fecundity	1.21060290
43	MP0002249_abnormal_larynx_morphology	1.18867859
44	MP0000003_abnormal_adipose_tissue	1.14924682
45	MP0005423_abnormal_somatic_nervous	1.13394438
46	MP0000678_abnormal_parathyroid_gland	1.12015082
47	MP0000470_abnormal_stomach_morphology	1.09571774
48	MP0003693_abnormal_embryo_hatching	1.06210047
49	MP0001502_abnormal_circadian_rhythm	1.04660192
50	MP0001764_abnormal_homeostasis	1.02460581
51	MP0002098_abnormal_vibrissa_morphology	1.01034193
52	MP0002118_abnormal_lipid_homeostasis	1.00556447
53	MP0003195_calcinosis	0.99872230
54	MP0001944_abnormal_pancreas_morphology	0.98561782
55	MP0009780_abnormal_chondrocyte_physiolo	0.98101373
56	MP0002210_abnormal_sex_determination	0.97915855
57	MP0005083_abnormal_biliary_tract	0.97816116
58	MP0006292_abnormal_olfactory_placode	0.97690650
59	MP0003453_abnormal_keratinocyte_physiol	0.94117285
60	MP0002138_abnormal_hepatobiliary_system	0.93107952
61	MP0005375_adipose_tissue_phenotype	0.92855610
62	MP0000653_abnormal_sex_gland	0.91106486
63	MP0005394_taste/olfaction_phenotype	0.90492818
64	MP0005499_abnormal_olfactory_system	0.90492818
65	MP0003329_amyloid_beta_deposits	0.89557163
66	MP0000750_abnormal_muscle_regeneration	0.87834039
67	MP0005666_abnormal_adipose_tissue	0.87726563
68	MP0001968_abnormal_touch/_nociception	0.86920478
69	MP0000762_abnormal_tongue_morphology	0.84415629
70	MP0004019_abnormal_vitamin_homeostasis	0.83816972
71	MP0002160_abnormal_reproductive_system	0.82882851
72	MP0000377_abnormal_hair_follicle	0.81423509
73	MP0001873_stomach_inflammation	0.80624170
74	MP0001661_extended_life_span	0.79832416
75	MP0009672_abnormal_birth_weight	0.78978603
76	MP0001986_abnormal_taste_sensitivity	0.76446046
77	MP0003122_maternal_imprinting	0.75799709
78	MP0010368_abnormal_lymphatic_system	0.75274421
79	MP0003959_abnormal_lean_body	0.75150649
80	MP0003183_abnormal_peptide_metabolism	0.73735498
81	MP0003698_abnormal_male_reproductive	0.73531124
82	MP0003121_genomic_imprinting	0.72713720
83	MP0000609_abnormal_liver_physiology	0.72503937
84	MP0003942_abnormal_urinary_system	0.72276230
85	MP0008789_abnormal_olfactory_epithelium	0.71511912
86	MP0005332_abnormal_amino_acid	0.71128444
87	MP0000538_abnormal_urinary_bladder	0.70402287
88	MP0010771_integument_phenotype	0.69107675
89	MP0005220_abnormal_exocrine_pancreas	0.68915210
90	MP0002970_abnormal_white_adipose	0.68654376
91	MP0002909_abnormal_adrenal_gland	0.68011310
92	MP0000026_abnormal_inner_ear	0.67742350
93	MP0001119_abnormal_female_reproductive	0.67129723
94	MP0009115_abnormal_fat_cell	0.66415913
95	MP0001730_embryonic_growth_arrest	0.65804872
96	MP0000467_abnormal_esophagus_morphology	0.65798655
97	MP0003868_abnormal_feces_composition	0.65733324
98	MP0002735_abnormal_chemical_nociception	0.63415472
99	MP0005646_abnormal_pituitary_gland	0.63034433
100	MP0000427_abnormal_hair_cycle	0.62907441

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	6.47094303
2	Cholecystitis (HP:0001082)	5.11957010
3	Abnormal gallbladder physiology (HP:0012438)	5.11957010
4	Prolonged partial thromboplastin time (HP:0003645)	4.62432606
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.71962447
6	Thin bony cortex (HP:0002753)	3.71360738
7	Aplasia of the musculature (HP:0100854)	3.59101802
8	Joint hemorrhage (HP:0005261)	3.54063192
9	Asymmetry of the thorax (HP:0001555)	3.44001412
10	Hemorrhage of the eye (HP:0011885)	3.42954362
11	Flat acetabular roof (HP:0003180)	3.35793381
12	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.28078328
13	Menstrual irregularities (HP:0000858)	3.08590442
14	Hypophosphatemic rickets (HP:0004912)	3.08338338
15	Facial hemangioma (HP:0000329)	2.99150868
16	Spinal cord compression (HP:0002176)	2.89075139
17	Enlarged penis (HP:0000040)	2.87285628
18	Ulnar claw (HP:0001178)	2.83183716
19	Testicular atrophy (HP:0000029)	2.74486647
20	J-shaped sella turcica (HP:0002680)	2.72128881
21	Growth hormone excess (HP:0000845)	2.63909831
22	Abnormality of carpal bone ossification (HP:0006257)	2.48920526
23	Septate vagina (HP:0001153)	2.46844056
24	Obstructive sleep apnea (HP:0002870)	2.44617889
25	Biconcave vertebral bodies (HP:0004586)	2.41531764
26	Delayed CNS myelination (HP:0002188)	2.39633398
27	Vaginal fistula (HP:0004320)	2.37829046
28	Long palpebral fissure (HP:0000637)	2.37666560
29	Intrahepatic cholestasis (HP:0001406)	2.35243227
30	Upper limb amyotrophy (HP:0009129)	2.33087814
31	Distal upper limb amyotrophy (HP:0007149)	2.33087814
32	Partial duplication of thumb phalanx (HP:0009944)	2.32803670
33	Hand muscle atrophy (HP:0009130)	2.32431448
34	Impulsivity (HP:0100710)	2.30087972
35	Broad distal phalanx of finger (HP:0009836)	2.28827282
36	Concave nail (HP:0001598)	2.28708288
37	Abnormal tarsal ossification (HP:0008369)	2.28529555
38	Hypoalphalipoproteinemia (HP:0003233)	2.27552822
39	Hypercortisolism (HP:0001578)	2.21520189
40	Cholelithiasis (HP:0001081)	2.20671551
41	Infertility (HP:0000789)	2.18779870
42	Progressive sensorineural hearing impairment (HP:0000408)	2.17054421
43	Abnormality of the Achilles tendon (HP:0005109)	2.16995049
44	Pterygium (HP:0001059)	2.15163566
45	Hypercholesterolemia (HP:0003124)	2.13637293
46	Lip pit (HP:0100267)	2.08704778
47	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.07527497
48	Lymphangioma (HP:0100764)	2.06712246
49	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.06490892
50	Stridor (HP:0010307)	2.06444733
51	Congenital glaucoma (HP:0001087)	2.03143243
52	Testicular neoplasm (HP:0010788)	1.99798948
53	Xanthomatosis (HP:0000991)	1.96901852
54	Osteomalacia (HP:0002749)	1.94142391
55	Achilles tendon contracture (HP:0001771)	1.90570041
56	Abnormality of the common coagulation pathway (HP:0010990)	1.90449825
57	Premature skin wrinkling (HP:0100678)	1.89648720
58	Ulnar bowing (HP:0003031)	1.89094043
59	Abnormal ossification of hand bones (HP:0005921)	1.88815863
60	Abnormality of the intrinsic pathway (HP:0010989)	1.88563396
61	Cervical subluxation (HP:0003308)	1.87986686
62	Abnormal urine phosphate concentration (HP:0012599)	1.86496545
63	Partial duplication of the phalanx of hand (HP:0009999)	1.86462421
64	Acanthosis nigricans (HP:0000956)	1.85851840
65	Vertebral compression fractures (HP:0002953)	1.85529385
66	Myokymia (HP:0002411)	1.82758760
67	Back pain (HP:0003418)	1.82273693
68	Abnormal gallbladder morphology (HP:0012437)	1.81932824
69	Bronchomalacia (HP:0002780)	1.81464345
70	Choanal stenosis (HP:0000452)	1.80554313
71	Microretrognathia (HP:0000308)	1.79860285
72	Poikiloderma (HP:0001029)	1.78126555
73	Large eyes (HP:0001090)	1.77648883
74	Abnormality of the umbilical cord (HP:0010881)	1.77431563
75	Male infertility (HP:0003251)	1.76194458
76	Abnormal hand bone ossification (HP:0010660)	1.76053218
77	Germ cell neoplasia (HP:0100728)	1.75549468
78	Myelomeningocele (HP:0002475)	1.73398239
79	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.72098089
80	Abnormality of the gallbladder (HP:0005264)	1.69751837
81	Anterior segment dysgenesis (HP:0007700)	1.69478359
82	Bell-shaped thorax (HP:0001591)	1.68209785
83	Hypolipoproteinemia (HP:0010981)	1.67807802
84	Flattened epiphyses (HP:0003071)	1.66744725
85	Easy fatigability (HP:0003388)	1.66463579
86	Spinal canal stenosis (HP:0003416)	1.65908087
87	Broad face (HP:0000283)	1.65410476
88	Diaphragmatic weakness (HP:0009113)	1.63284029
89	Late onset (HP:0003584)	1.61151302
90	Premature ovarian failure (HP:0008209)	1.60060126
91	Seborrheic dermatitis (HP:0001051)	1.59478120
92	Diminished motivation (HP:0000745)	1.58874063
93	Delayed epiphyseal ossification (HP:0002663)	1.57793692
94	Apathy (HP:0000741)	1.57791438
95	Abnormal atrioventricular conduction (HP:0005150)	1.57434762
96	Hypergonadotropic hypogonadism (HP:0000815)	1.56769399
97	Microglossia (HP:0000171)	1.56726441
98	Hypoplastic pelvis (HP:0008839)	1.55916654
99	Rickets (HP:0002748)	1.55397979
100	Hypokinesia (HP:0002375)	1.54654283

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	8.86524583
2	PKN2	4.21555937
3	MUSK	3.54688452
4	ARAF	3.54556036
5	EPHA2	3.33690593
6	EEF2K	3.33384430
7	SIK1	2.59098920
8	STK16	2.52951203
9	MAP3K9	2.22709200
10	CDK12	2.21889347
11	TESK1	1.98309623
12	TESK2	1.91503746
13	MAPK15	1.89914410
14	ICK	1.85712551
15	MAPKAPK3	1.68425807
16	BRAF	1.66098360
17	ERN1	1.60795465
18	ILK	1.50009976
19	PRPF4B	1.40133116
20	BCKDK	1.34474296
21	PDPK1	1.34127909
22	FGFR4	1.33479452
23	PRKCI	1.30876332
24	WNK4	1.29157231
25	NEK6	1.26880937
26	MAP3K13	1.25188968
27	SMG1	1.14956301
28	NME2	1.13245941
29	CAMKK1	1.08732648
30	IRAK3	1.00153021
31	PTK6	0.99439498
32	MTOR	0.99114119
33	DYRK1B	0.97690516
34	LRRK2	0.97188254
35	CDK7	0.94344939
36	TAOK2	0.93801952
37	RIPK1	0.90273102
38	AURKA	0.85672108
39	PIM2	0.84900273
40	PTK2	0.83158111
41	MET	0.79232612
42	RPS6KB2	0.77549439
43	VRK2	0.77472979
44	PDK1	0.75951258
45	TBK1	0.73568497
46	WNK1	0.73514629
47	SIK2	0.71430182
48	MARK2	0.70820646
49	CAMK1D	0.68427976
50	CDK9	0.66398770
51	RET	0.66324025
52	PAK4	0.65176714
53	TNK2	0.64928935
54	KSR2	0.64915633
55	GRK6	0.61898714
56	PRKD2	0.57119938
57	IRAK2	0.55663650
58	RPS6KA2	0.53919994
59	STK39	0.53082162
60	STK24	0.52422847
61	BRSK1	0.49748031
62	NTRK2	0.49712722
63	MAP3K1	0.48472526
64	CHUK	0.46380732
65	PRKD3	0.45307226
66	MAP2K2	0.45205110
67	MST1R	0.43589869
68	AKT2	0.42257718
69	STK38	0.41249758
70	LMTK2	0.40802564
71	SIK3	0.34970628
72	MAP3K11	0.34551632
73	MAPK11	0.32689297
74	MELK	0.32134972
75	MAP3K3	0.32011794
76	TAOK1	0.31919726
77	BMX	0.31751221
78	HIPK2	0.31526478
79	PRKD1	0.31003522
80	PRKCZ	0.30960881
81	TYRO3	0.28894562
82	CSNK1D	0.27638455
83	MAPK8	0.26596270
84	RAF1	0.26185426
85	CDK11A	0.24218027
86	PRKG2	0.24107022
87	MAPKAPK2	0.23528889
88	CDK15	0.21322089
89	CDK2	0.20273232
90	CAMK4	0.19273530
91	RPS6KC1	0.19174521
92	RPS6KL1	0.19174521
93	DDR2	0.17866140
94	RPS6KB1	0.17765311
95	IKBKE	0.17159338
96	TRIM28	0.17111951
97	CDK18	0.16820701
98	CAMK2G	0.16766235
99	GSK3B	0.16321821
100	CDK1	0.15803458

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	2.99155612
2	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.47736002
3	Phenylalanine metabolism_Homo sapiens_hsa00360	2.31669170
4	Arginine biosynthesis_Homo sapiens_hsa00220	2.23666077
5	Complement and coagulation cascades_Homo sapiens_hsa04610	2.08635962
6	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.99069604
7	Sphingolipid metabolism_Homo sapiens_hsa00600	1.88552013
8	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.88081800
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87836120
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.86997922
11	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.81108978
12	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.69872174
13	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.65276128
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.63758317
15	Bile secretion_Homo sapiens_hsa04976	1.53549932
16	mTOR signaling pathway_Homo sapiens_hsa04150	1.50763690
17	Endometrial cancer_Homo sapiens_hsa05213	1.44017479
18	Notch signaling pathway_Homo sapiens_hsa04330	1.43168734
19	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.41044029
20	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.37438709
21	Other glycan degradation_Homo sapiens_hsa00511	1.32745866
22	AMPK signaling pathway_Homo sapiens_hsa04152	1.32452865
23	Tyrosine metabolism_Homo sapiens_hsa00350	1.32066000
24	VEGF signaling pathway_Homo sapiens_hsa04370	1.28358588
25	Insulin resistance_Homo sapiens_hsa04931	1.27610200
26	Insulin signaling pathway_Homo sapiens_hsa04910	1.27176840
27	Non-small cell lung cancer_Homo sapiens_hsa05223	1.27152800
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.26304563
29	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.20985876
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20650802
31	Vibrio cholerae infection_Homo sapiens_hsa05110	1.17941777
32	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.16874655
33	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.16297321
34	Lysine degradation_Homo sapiens_hsa00310	1.14826409
35	PPAR signaling pathway_Homo sapiens_hsa03320	1.08974854
36	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.06002736
37	Histidine metabolism_Homo sapiens_hsa00340	1.04791848
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.04760016
39	Glucagon signaling pathway_Homo sapiens_hsa04922	1.02716781
40	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.02541143
41	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.98872043
42	Base excision repair_Homo sapiens_hsa03410	0.98596198
43	Acute myeloid leukemia_Homo sapiens_hsa05221	0.96894566
44	Arginine and proline metabolism_Homo sapiens_hsa00330	0.93204422
45	Estrogen signaling pathway_Homo sapiens_hsa04915	0.90857013
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90580841
47	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.90237615
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.89201430
49	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89190056
50	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.88550168
51	ErbB signaling pathway_Homo sapiens_hsa04012	0.88348730
52	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.87455613
53	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.86625913
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.84027933
55	Pentose phosphate pathway_Homo sapiens_hsa00030	0.83639195
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83478652
57	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.83239208
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.82867780
59	Cocaine addiction_Homo sapiens_hsa05030	0.81525820
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.80788241
61	Prion diseases_Homo sapiens_hsa05020	0.80381361
62	Thyroid cancer_Homo sapiens_hsa05216	0.78196780
63	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.77813762
64	ABC transporters_Homo sapiens_hsa02010	0.76472143
65	Fatty acid degradation_Homo sapiens_hsa00071	0.74077006
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.73110761
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.72173898
68	Prostate cancer_Homo sapiens_hsa05215	0.70750418
69	Fatty acid elongation_Homo sapiens_hsa00062	0.70118382
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.69814210
71	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.68810076
72	Tight junction_Homo sapiens_hsa04530	0.63317290
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.63249089
74	Carbon metabolism_Homo sapiens_hsa01200	0.62664624
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62243199
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60967305
77	Caffeine metabolism_Homo sapiens_hsa00232	0.60424342
78	Fatty acid metabolism_Homo sapiens_hsa01212	0.60231290
79	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59521397
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.59072405
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.58915412
82	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.58238441
83	Basal transcription factors_Homo sapiens_hsa03022	0.57598885
84	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.55407899
85	Hepatitis C_Homo sapiens_hsa05160	0.54141727
86	Circadian rhythm_Homo sapiens_hsa04710	0.52647209
87	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.52282299
88	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.52020507
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.51531744
90	Choline metabolism in cancer_Homo sapiens_hsa05231	0.49430259
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48830470
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.48714737
93	Gap junction_Homo sapiens_hsa04540	0.47229608
94	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.46337971
95	Galactose metabolism_Homo sapiens_hsa00052	0.45619701
96	Renal cell carcinoma_Homo sapiens_hsa05211	0.45447883
97	Glioma_Homo sapiens_hsa05214	0.42634801
98	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.42519461
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42079544
100	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.40463203

CNTD2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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