CNTF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.90216941
2cilium or flagellum-dependent cell motility (GO:0001539)8.79792182
3cilium movement (GO:0003341)8.70648077
4axoneme assembly (GO:0035082)7.66477640
5nuclear pore complex assembly (GO:0051292)6.45000960
6central nervous system myelination (GO:0022010)6.44440107
7axon ensheathment in central nervous system (GO:0032291)6.44440107
8epithelial cilium movement (GO:0003351)5.82956643
9ventricular system development (GO:0021591)5.79167460
10GTP biosynthetic process (GO:0006183)5.74807288
11regulation of glucose import in response to insulin stimulus (GO:2001273)5.39151694
12nuclear pore organization (GO:0006999)5.29880821
13UTP biosynthetic process (GO:0006228)5.27011222
14negative regulation of homotypic cell-cell adhesion (GO:0034111)5.26757505
15UTP metabolic process (GO:0046051)5.02869512
16motile cilium assembly (GO:0044458)4.88720362
17protein palmitoylation (GO:0018345)4.70976152
18peripheral nervous system axon ensheathment (GO:0032292)4.70158637
19myelination in peripheral nervous system (GO:0022011)4.70158637
20pore complex assembly (GO:0046931)4.69809105
21mitotic sister chromatid cohesion (GO:0007064)4.50457478
22microtubule severing (GO:0051013)4.43950076
23nucleoside diphosphate phosphorylation (GO:0006165)4.43924903
24long-chain fatty acid biosynthetic process (GO:0042759)4.28855912
25microtubule bundle formation (GO:0001578)4.22219785
26mitotic chromosome condensation (GO:0007076)4.18074111
27asymmetric protein localization (GO:0008105)4.08945434
28myelin maintenance (GO:0043217)4.07366213
29regulation of platelet aggregation (GO:0090330)4.02966093
30CTP metabolic process (GO:0046036)3.91016738
31CTP biosynthetic process (GO:0006241)3.91016738
32regulation of mitochondrial depolarization (GO:0051900)3.86449891
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84497485
34positive regulation of cellular response to insulin stimulus (GO:1900078)3.77297981
35regulation of RNA export from nucleus (GO:0046831)3.74881220
36protein localization to chromosome, centromeric region (GO:0071459)3.71371821
37pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.68218994
38axon ensheathment (GO:0008366)3.67988421
39ensheathment of neurons (GO:0007272)3.67988421
40mitotic metaphase plate congression (GO:0007080)3.67216201
41ADP metabolic process (GO:0046031)3.65324019
42apical protein localization (GO:0045176)3.64114111
43negative regulation of platelet activation (GO:0010544)3.60056577
44pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.60037225
45myelination (GO:0042552)3.57075989
46poly(A)+ mRNA export from nucleus (GO:0016973)3.51359121
47peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.47260372
48DNA unwinding involved in DNA replication (GO:0006268)3.45809904
49embryonic process involved in female pregnancy (GO:0060136)3.45369178
50sister chromatid segregation (GO:0000819)3.43522349
51guanosine-containing compound biosynthetic process (GO:1901070)3.43440462
52hepatocyte differentiation (GO:0070365)3.43115068
533-UTR-mediated mRNA stabilization (GO:0070935)3.41140125
54regulation of nucleobase-containing compound transport (GO:0032239)3.37452518
55peptidyl-tyrosine autophosphorylation (GO:0038083)3.37049296
56neuronal ion channel clustering (GO:0045161)3.36984990
57mitotic sister chromatid segregation (GO:0000070)3.36816493
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.36684763
59L-amino acid import (GO:0043092)3.35950289
60mitotic nuclear envelope disassembly (GO:0007077)3.34059312
61negative regulation of DNA repair (GO:0045738)3.31504604
62establishment or maintenance of apical/basal cell polarity (GO:0035088)3.30498010
63establishment or maintenance of bipolar cell polarity (GO:0061245)3.30498010
64ribosome assembly (GO:0042255)3.28655542
65membrane disassembly (GO:0030397)3.28512918
66nuclear envelope disassembly (GO:0051081)3.28512918
67cellular protein complex localization (GO:0034629)3.28179841
68left/right axis specification (GO:0070986)3.27972898
69DNA topological change (GO:0006265)3.27588832
70tolerance induction (GO:0002507)3.23000622
71hair follicle development (GO:0001942)3.19996782
72amino acid import (GO:0043090)3.18934030
73heart valve formation (GO:0003188)3.17024098
74DNA duplex unwinding (GO:0032508)3.14784435
75one-carbon compound transport (GO:0019755)3.12127792
76eye photoreceptor cell differentiation (GO:0001754)3.11595311
77photoreceptor cell differentiation (GO:0046530)3.11595311
78regulation of pigment cell differentiation (GO:0050932)3.11592533
79iron ion import (GO:0097286)3.10999052
80negative regulation of erythrocyte differentiation (GO:0045647)3.09986276
81microtubule-based movement (GO:0007018)3.09831506
82negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.09703773
83establishment of chromosome localization (GO:0051303)3.07352798
84pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05845812
85protoporphyrinogen IX metabolic process (GO:0046501)3.03842932
86dosage compensation (GO:0007549)3.03474070
87primary alcohol catabolic process (GO:0034310)3.02522044
88regulation of translational fidelity (GO:0006450)3.01597426
89DNA geometric change (GO:0032392)3.00931359
90acrosome assembly (GO:0001675)3.00097296
91regulation of histone H3-K27 methylation (GO:0061085)3.00005905
92regulation of homotypic cell-cell adhesion (GO:0034110)2.99790462
93positive regulation of endothelial cell differentiation (GO:0045603)2.98243220
94metaphase plate congression (GO:0051310)2.97256837
954-hydroxyproline metabolic process (GO:0019471)2.96730841
96oligodendrocyte differentiation (GO:0048709)2.94647482
97histone phosphorylation (GO:0016572)2.93732807
98linoleic acid metabolic process (GO:0043651)2.93688559
99nephron tubule formation (GO:0072079)2.92903954
100microtubule depolymerization (GO:0007019)2.90806564
101definitive hemopoiesis (GO:0060216)2.88846581
102cytoskeletal anchoring at plasma membrane (GO:0007016)2.86150744
103cellular response to cholesterol (GO:0071397)2.85462187
104regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84795449
105nuclear envelope organization (GO:0006998)2.83964845
106cilium morphogenesis (GO:0060271)2.83375625
107response to methylmercury (GO:0051597)2.82736959
108import into cell (GO:0098657)2.81664771
109trophoblast giant cell differentiation (GO:0060707)2.80238951
110left/right pattern formation (GO:0060972)2.79206862
111Sertoli cell development (GO:0060009)2.78230957
112positive regulation of astrocyte differentiation (GO:0048711)2.78158020
113RNA stabilization (GO:0043489)2.77040850
114mRNA stabilization (GO:0048255)2.77040850
115regulation of translational termination (GO:0006449)2.74972834
116disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.74584615
117killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.74584615
118neuronal action potential propagation (GO:0019227)2.73309763
119intraciliary transport (GO:0042073)2.73252266
120nucleoside diphosphate metabolic process (GO:0009132)2.71532023
121regulation of macrophage chemotaxis (GO:0010758)2.71075806
122establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.70934089
123short-chain fatty acid metabolic process (GO:0046459)2.70811714
124positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.67600558
125progesterone metabolic process (GO:0042448)2.67073743
126water-soluble vitamin biosynthetic process (GO:0042364)2.66514732
127DNA conformation change (GO:0071103)2.66288768
128response to peptidoglycan (GO:0032494)2.65517302
129cilium organization (GO:0044782)2.64072886
130response to muramyl dipeptide (GO:0032495)2.63663103
131nucleotide phosphorylation (GO:0046939)2.63057579
132regulation of DNA damage checkpoint (GO:2000001)2.62138794
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.60373106
134hypotonic response (GO:0006971)2.60110460
135negative regulation of Rho protein signal transduction (GO:0035024)2.59685734
136regulation of sister chromatid cohesion (GO:0007063)2.59596121
137response to laminar fluid shear stress (GO:0034616)2.59413862
138nerve growth factor signaling pathway (GO:0038180)2.59153217
139spliceosomal tri-snRNP complex assembly (GO:0000244)2.58157488
140regulation of spindle organization (GO:0090224)2.57877437
141cortical cytoskeleton organization (GO:0030865)2.56915014
142positive regulation of chromosome segregation (GO:0051984)2.55631380
143low-density lipoprotein particle remodeling (GO:0034374)2.54648436
144DNA strand elongation (GO:0022616)2.54644558
145C21-steroid hormone biosynthetic process (GO:0006700)2.53554242
146positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53489234
147positive regulation of mitotic sister chromatid separation (GO:1901970)2.53489234
148positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53489234
149gas transport (GO:0015669)2.53262441
150cellular hyperosmotic response (GO:0071474)2.52797394
151germinal center formation (GO:0002467)2.52348262
152regulation of mitotic spindle organization (GO:0060236)2.52136031
153regulation of membrane depolarization (GO:0003254)2.52121918
154positive regulation of protein import into nucleus, translocation (GO:0033160)2.51952638
155peptidyl-proline hydroxylation (GO:0019511)2.51700748
156cellular response to sterol (GO:0036315)2.51457158
157aldehyde catabolic process (GO:0046185)2.50358135
158neuron remodeling (GO:0016322)2.50034574
159skeletal muscle adaptation (GO:0043501)2.49204903
160DNA synthesis involved in DNA repair (GO:0000731)2.48695727
161DNA strand elongation involved in DNA replication (GO:0006271)2.46797227
162positive regulation of glucose import (GO:0046326)2.45425593
163cortical actin cytoskeleton organization (GO:0030866)2.45122612
164chromosome condensation (GO:0030261)2.45067034
165membrane raft organization (GO:0031579)2.44141174
166protein localization to endosome (GO:0036010)2.43842171
167cellular response to arsenic-containing substance (GO:0071243)2.43316919
168protein localization to kinetochore (GO:0034501)2.41989591
169protoporphyrinogen IX biosynthetic process (GO:0006782)2.41943530
170centriole assembly (GO:0098534)2.41335880
171DNA replication initiation (GO:0006270)2.40529844
172regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.40505848
173natural killer cell mediated cytotoxicity (GO:0042267)2.37915229
174natural killer cell mediated immunity (GO:0002228)2.37915229
175negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37057579
176double-strand break repair via nonhomologous end joining (GO:0006303)2.36788091
177non-recombinational repair (GO:0000726)2.36788091
178megakaryocyte development (GO:0035855)2.35616124
179pinocytosis (GO:0006907)2.33881292
180nucleobase-containing small molecule interconversion (GO:0015949)2.33304860
181positive regulation of cell cycle checkpoint (GO:1901978)2.32801913
182response to arsenic-containing substance (GO:0046685)2.31584004
183protein complex localization (GO:0031503)2.29888041
184deoxyribonucleotide biosynthetic process (GO:0009263)2.26930045
185mammary gland epithelial cell proliferation (GO:0033598)2.26599024
186regulation of DNA endoreduplication (GO:0032875)2.26347400
187regulation of NFAT protein import into nucleus (GO:0051532)2.26189804
188activation of Rac GTPase activity (GO:0032863)2.25705586
189positive regulation of DNA-dependent DNA replication (GO:2000105)2.24492545
190regulation of centriole replication (GO:0046599)2.23462691
191negative regulation of humoral immune response (GO:0002921)2.22254262
192hepatocyte apoptotic process (GO:0097284)2.21340879
193cytoplasmic mRNA processing body assembly (GO:0033962)2.19370007
194protein export from nucleus (GO:0006611)2.19161226
195regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.18695417
196DNA packaging (GO:0006323)2.18001291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.28404524
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.03164301
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.23352118
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.94409169
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.63389242
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23706247
7SMAD_19615063_ChIP-ChIP_OVARY_Human3.17659585
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.17011317
9CDX2_19796622_ChIP-Seq_MESCs_Mouse3.10089203
10AR_21572438_ChIP-Seq_LNCaP_Human3.00785555
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89182945
12MYC_22102868_ChIP-Seq_BL_Human2.86318783
13AR_21909140_ChIP-Seq_LNCAP_Human2.71373992
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64237803
15EZH2_22144423_ChIP-Seq_EOC_Human2.36340221
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21540919
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15401016
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02398515
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.00785811
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90978491
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86691301
22VDR_21846776_ChIP-Seq_THP-1_Human1.85072810
23TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84402754
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.78171907
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.75599723
26ZNF263_19887448_ChIP-Seq_K562_Human1.70131985
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65094324
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64781880
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62809357
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60462589
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60034446
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59618981
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59592821
34TCF7_22412390_ChIP-Seq_EML_Mouse1.58649944
35TFEB_21752829_ChIP-Seq_HELA_Human1.57794487
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.57076385
37MAF_26560356_Chip-Seq_TH1_Human1.55132167
38CIITA_25753668_ChIP-Seq_RAJI_Human1.54059569
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52867917
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52611542
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52333874
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50231959
43LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48230276
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47444674
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46361906
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46360660
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45018644
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44075379
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44037057
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42720704
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42720704
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40870801
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.38402263
54DCP1A_22483619_ChIP-Seq_HELA_Human1.38241219
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37992550
56VDR_24763502_ChIP-Seq_THP-1_Human1.37560073
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37515901
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37324689
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37324689
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36452027
61LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36446348
62MYB_26560356_Chip-Seq_TH2_Human1.36316112
63* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35640398
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34723507
65MYB_26560356_Chip-Seq_TH1_Human1.34718744
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34700588
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.33940749
68SPI1_23547873_ChIP-Seq_NB4_Human1.33526104
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33333466
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.33182611
71BCAT_22108803_ChIP-Seq_LS180_Human1.32916970
72SMAD4_21799915_ChIP-Seq_A2780_Human1.32465951
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32154142
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32154142
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31640279
76ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30795038
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29992385
78SCL_19346495_ChIP-Seq_HPC-7_Human1.29390769
79KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28901515
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28859354
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28756743
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28631021
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28054540
84MYC_19030024_ChIP-ChIP_MESCs_Mouse1.27451018
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26746761
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25737831
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.24365175
88CLOCK_20551151_ChIP-Seq_293T_Human1.23600217
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.22240688
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.21330215
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21246751
92GATA1_22025678_ChIP-Seq_K562_Human1.21130207
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20824419
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.20443716
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20128535
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19963243
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19464685
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19459696
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19127221
100* CHD1_26751641_Chip-Seq_LNCaP_Human1.18591006
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.18517696
102GATA1_19941826_ChIP-Seq_K562_Human1.18326968
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18053837
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17852517
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17453538
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17353019
107SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.17315693
108SOX2_20726797_ChIP-Seq_SW620_Human1.17167776
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.17008629
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.16958548
111NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16498902
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.16231977
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16105899
114TCF4_22108803_ChIP-Seq_LS180_Human1.15779314
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15224656
116AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14958016
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14464354
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14122356
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13655554
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.13509667
121NCOR1_26117541_ChIP-Seq_K562_Human1.12645887
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.12398640
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.11879904
124SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11872330
125MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11618213
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11419059
127OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09815102
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.08972366
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08905402
130GBX2_23144817_ChIP-Seq_PC3_Human1.08703792
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07786612
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06817044
133ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06491948
134ATF3_27146783_Chip-Seq_COLON_Human1.06312056
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05506042
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05076837
137P300_19829295_ChIP-Seq_ESCs_Human1.04834421
138SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04244586
139ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04082405
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03962746
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03608505
142CJUN_26792858_Chip-Seq_BT549_Human1.03154779
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02406946
144SMAD3_21741376_ChIP-Seq_ESCs_Human1.02217325
145NFE2_27457419_Chip-Seq_LIVER_Mouse1.02172656
146ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02164007
147ERG_21242973_ChIP-ChIP_JURKAT_Human1.02031279
148P300_18555785_Chip-Seq_ESCs_Mouse1.01861497
149RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01731024
150STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01454818
151E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01437573
152P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01425337
153UBF1/2_26484160_Chip-Seq_HMECs_Human1.01052533
154CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00988324
155SMAD4_21741376_ChIP-Seq_EPCs_Human1.00931393
156RNF2_27304074_Chip-Seq_NSC_Mouse1.00880744
157FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99921306
158PU_27001747_Chip-Seq_BMDM_Mouse0.99282855
159* HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98868506
160GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98626393
161UTX_26944678_Chip-Seq_JUKART_Human0.98276905
162NFYB_21822215_ChIP-Seq_K562_Human0.98145774
163P53_22387025_ChIP-Seq_ESCs_Mouse0.98103143
164SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97278924
165PHF8_20622853_ChIP-Seq_HELA_Human0.96996492
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96948401
167KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95763558
168TBL1_22424771_ChIP-Seq_293T_Human0.95500238
169SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95392973
170KDM5A_27292631_Chip-Seq_BREAST_Human0.95212545
171GATA2_19941826_ChIP-Seq_K562_Human0.95079047
172FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95000123
173* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93840689
174TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93592430
175SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93519394
176STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93393140
177PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92782659
178OCT4_18555785_Chip-Seq_ESCs_Mouse0.92538026
179RING1B_27294783_Chip-Seq_NPCs_Mouse0.92025364
180SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91859702
181SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91442760
182TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91167608
183DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90713727
184EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90428459
185PIAS1_25552417_ChIP-Seq_VCAP_Human0.90261039
186TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89834260
187* STAT3_23295773_ChIP-Seq_U87_Human0.89750485
188TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89487014
189GF1B_26923725_Chip-Seq_HPCs_Mouse0.89273274
190TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89163318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology4.55236984
2MP0003136_yellow_coat_color4.42860501
3MP0008057_abnormal_DNA_replication4.29706432
4MP0005257_abnormal_intraocular_pressure3.80393663
5MP0005645_abnormal_hypothalamus_physiol3.52543636
6MP0010352_gastrointestinal_tract_polyps3.23897728
7MP0008260_abnormal_autophagy3.20677977
8MP0000920_abnormal_myelination2.92696837
9MP0010094_abnormal_chromosome_stability2.91792697
10MP0004858_abnormal_nervous_system2.89792194
11MP0002009_preneoplasia2.82153505
12MP0000749_muscle_degeneration2.74311883
13MP0002735_abnormal_chemical_nociception2.64750172
14MP0004272_abnormal_basement_membrane2.60043558
15MP0003111_abnormal_nucleus_morphology2.57541468
16MP0002877_abnormal_melanocyte_morpholog2.57053307
17MP0003950_abnormal_plasma_membrane2.56973606
18MP0005076_abnormal_cell_differentiation2.54237040
19MP0003693_abnormal_embryo_hatching2.48675242
20MP0002396_abnormal_hematopoietic_system2.48455674
21MP0003705_abnormal_hypodermis_morpholog2.46912219
22MP0001661_extended_life_span2.37897118
23MP0002733_abnormal_thermal_nociception2.37835152
24MP0009046_muscle_twitch2.32404137
25MP0004133_heterotaxia2.29041508
26MP0002734_abnormal_mechanical_nocicepti2.28074832
27MP0003077_abnormal_cell_cycle2.26284105
28MP0003656_abnormal_erythrocyte_physiolo2.19351276
29MP0004808_abnormal_hematopoietic_stem2.16430392
30* MP0003634_abnormal_glial_cell2.14109961
31MP0003690_abnormal_glial_cell2.13458010
32MP0002928_abnormal_bile_duct2.13396353
33MP0004742_abnormal_vestibular_system2.10017787
34MP0004957_abnormal_blastocyst_morpholog1.98229515
35MP0002938_white_spotting1.97215726
36MP0010307_abnormal_tumor_latency1.92872303
37MP0001986_abnormal_taste_sensitivity1.91241384
38MP0001970_abnormal_pain_threshold1.87639996
39MP0006276_abnormal_autonomic_nervous1.84604823
40MP0005083_abnormal_biliary_tract1.81193435
41MP0001853_heart_inflammation1.80684646
42MP0009053_abnormal_anal_canal1.80423266
43MP0005451_abnormal_body_composition1.79979832
44MP0003329_amyloid_beta_deposits1.79531431
45MP0003763_abnormal_thymus_physiology1.77060091
46MP0003828_pulmonary_edema1.75742858
47MP0003303_peritoneal_inflammation1.67742091
48MP0005670_abnormal_white_adipose1.67175696
49MP0002166_altered_tumor_susceptibility1.64566915
50MP0008569_lethality_at_weaning1.62639151
51MP0001968_abnormal_touch/_nociception1.61825760
52MP0003011_delayed_dark_adaptation1.58772475
53MP0000350_abnormal_cell_proliferation1.58553928
54MP0008058_abnormal_DNA_repair1.57797258
55MP0008007_abnormal_cellular_replicative1.56382899
56MP0003191_abnormal_cellular_cholesterol1.54330316
57MP0001730_embryonic_growth_arrest1.53111713
58MP0001835_abnormal_antigen_presentation1.50319510
59MP0003436_decreased_susceptibility_to1.49100036
60MP0004233_abnormal_muscle_weight1.48794980
61MP0003453_abnormal_keratinocyte_physiol1.47423059
62MP0002272_abnormal_nervous_system1.46473045
63MP0002282_abnormal_trachea_morphology1.44859589
64MP0005409_darkened_coat_color1.43084052
65MP0004381_abnormal_hair_follicle1.42826944
66MP0004270_analgesia1.41340881
67MP0002006_tumorigenesis1.40828239
68MP0002736_abnormal_nociception_after1.38704202
69MP0004947_skin_inflammation1.38062559
70MP0003880_abnormal_central_pattern1.38019265
71MP0000778_abnormal_nervous_system1.37338344
72MP0005397_hematopoietic_system_phenotyp1.34085995
73MP0001545_abnormal_hematopoietic_system1.34085995
74MP0002638_abnormal_pupillary_reflex1.33190988
75MP0003221_abnormal_cardiomyocyte_apopto1.33179130
76MP0010234_abnormal_vibrissa_follicle1.32954694
77MP0003091_abnormal_cell_migration1.31408370
78MP0001485_abnormal_pinna_reflex1.30848374
79MP0005621_abnormal_cell_physiology1.29349926
80MP0001672_abnormal_embryogenesis/_devel1.27931575
81MP0005380_embryogenesis_phenotype1.27931575
82MP0003984_embryonic_growth_retardation1.25118282
83MP0002332_abnormal_exercise_endurance1.23113699
84MP0003632_abnormal_nervous_system1.20891240
85MP0008875_abnormal_xenobiotic_pharmacok1.19620812
86MP0002088_abnormal_embryonic_growth/wei1.19438654
87MP0003941_abnormal_skin_development1.19331743
88MP0002064_seizures1.19064103
89MP0002398_abnormal_bone_marrow1.18929349
90MP0002086_abnormal_extraembryonic_tissu1.16635667
91MP0001486_abnormal_startle_reflex1.16102393
92MP0002132_abnormal_respiratory_system1.15946955
93MP0000858_altered_metastatic_potential1.15635015
94* MP0003633_abnormal_nervous_system1.15589833
95MP0000733_abnormal_muscle_development1.15140993
96MP0009697_abnormal_copulation1.15100249
97MP0001299_abnormal_eye_distance/1.14947996
98MP0004130_abnormal_muscle_cell1.14641186
99MP0002019_abnormal_tumor_incidence1.14190111
100MP0009250_abnormal_appendicular_skeleto1.14164213
101MP0004145_abnormal_muscle_electrophysio1.14097770
102MP0009278_abnormal_bone_marrow1.13281704
103MP0009780_abnormal_chondrocyte_physiolo1.11685455
104MP0001915_intracranial_hemorrhage1.11638678
105MP0005275_abnormal_skin_tensile1.11221370
106* MP0003631_nervous_system_phenotype1.11109254
107MP0002080_prenatal_lethality1.11089611
108MP0003448_altered_tumor_morphology1.10749848
109MP0008932_abnormal_embryonic_tissue1.09948344
110MP0003786_premature_aging1.08445256
111MP0000313_abnormal_cell_death1.08101187
112MP0000569_abnormal_digit_pigmentation1.07826270
113MP0000703_abnormal_thymus_morphology1.07481373
114MP0002697_abnormal_eye_size1.06412617
115MP0000751_myopathy1.06122874
116MP0003938_abnormal_ear_development1.03945196
117MP0002139_abnormal_hepatobiliary_system1.03676271
118MP0002722_abnormal_immune_system1.00900913
119MP0004185_abnormal_adipocyte_glucose0.99431243
120MP0005384_cellular_phenotype0.97837772
121MP0002882_abnormal_neuron_morphology0.97543823
122MP0002896_abnormal_bone_mineralization0.97212785
123MP0005410_abnormal_fertilization0.96814178
124MP0003566_abnormal_cell_adhesion0.95565879
125MP0001697_abnormal_embryo_size0.94972494
126MP0004197_abnormal_fetal_growth/weight/0.94825732
127MP0002060_abnormal_skin_morphology0.94452470
128MP0002405_respiratory_system_inflammati0.93571425
129MP0001348_abnormal_lacrimal_gland0.93416213
130MP0004264_abnormal_extraembryonic_tissu0.93208168
131MP0000428_abnormal_craniofacial_morphol0.93113556
132MP0002067_abnormal_sensory_capabilities0.92467546
133MP0005310_abnormal_salivary_gland0.92005798
134* MP0000747_muscle_weakness0.91302861
135MP0005464_abnormal_platelet_physiology0.89313705
136MP0005000_abnormal_immune_tolerance0.88845659
137MP0000689_abnormal_spleen_morphology0.87808455
138* MP0002429_abnormal_blood_cell0.87191897
139MP0003890_abnormal_embryonic-extraembry0.86555905
140MP0002419_abnormal_innate_immunity0.86246500
141MP0002452_abnormal_antigen_presenting0.85701390
142MP0005501_abnormal_skin_physiology0.85165888
143MP0000534_abnormal_ureter_morphology0.84610074
144MP0001800_abnormal_humoral_immune0.84500070
145MP0000358_abnormal_cell_content/0.84382828
146MP0000759_abnormal_skeletal_muscle0.83215519
147MP0002420_abnormal_adaptive_immunity0.82087300
148MP0004087_abnormal_muscle_fiber0.81752404
149* MP0000716_abnormal_immune_system0.81243783
150MP0000685_abnormal_immune_system0.81087947
151MP0005058_abnormal_lysosome_morphology0.81066795
152MP0000604_amyloidosis0.79952571
153MP0001819_abnormal_immune_cell0.79402647
154MP0002160_abnormal_reproductive_system0.79354559
155MP0001216_abnormal_epidermal_layer0.78803294
156MP0004859_abnormal_synaptic_plasticity0.78421896
157* MP0002066_abnormal_motor_capabilities/c0.78407732
158MP0002152_abnormal_brain_morphology0.77259097
159MP0009115_abnormal_fat_cell0.76777548
160MP0000490_abnormal_crypts_of0.75630924
161MP0003635_abnormal_synaptic_transmissio0.75519543
162MP0002752_abnormal_somatic_nervous0.75462191
163MP0006035_abnormal_mitochondrial_morpho0.75325561
164MP0003075_altered_response_to0.75011567
165MP0005360_urolithiasis0.75009933
166MP0010630_abnormal_cardiac_muscle0.74035514
167MP0003646_muscle_fatigue0.73697521
168MP0004883_abnormal_blood_vessel0.73474381
169MP0005666_abnormal_adipose_tissue0.73234853
170MP0005647_abnormal_sex_gland0.72719310
171MP0006292_abnormal_olfactory_placode0.72449982
172MP0005408_hypopigmentation0.72118518
173MP0003937_abnormal_limbs/digits/tail_de0.71677356
174MP0002249_abnormal_larynx_morphology0.70042512
175MP0008004_abnormal_stomach_pH0.69803842
176MP0003385_abnormal_body_wall0.69508256
177MP0003861_abnormal_nervous_system0.69420099
178MP0002269_muscular_atrophy0.69147723
179MP0002295_abnormal_pulmonary_circulatio0.68888038
180MP0003172_abnormal_lysosome_physiology0.68353642
181MP0002653_abnormal_ependyma_morphology0.67955157
182MP0005193_abnormal_anterior_eye0.67913588
183MP0005075_abnormal_melanosome_morpholog0.66172881
184MP0001963_abnormal_hearing_physiology0.65155227
185MP0003300_gastrointestinal_ulcer0.64982460
186MP0005165_increased_susceptibility_to0.63441901
187MP0010678_abnormal_skin_adnexa0.63078989
188MP0003045_fibrosis0.61004692
189MP0004811_abnormal_neuron_physiology0.60331039

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.93973138
2Abnormal ciliary motility (HP:0012262)7.68832766
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.42211602
4Rhinitis (HP:0012384)6.90214531
5Termporal pattern (HP:0011008)6.85129745
6Insidious onset (HP:0003587)6.85129745
7Abnormal respiratory epithelium morphology (HP:0012253)5.45173352
8Abnormal respiratory motile cilium morphology (HP:0005938)5.45173352
9Action tremor (HP:0002345)5.32531481
10Ulnar claw (HP:0001178)5.20255594
11Disinhibition (HP:0000734)4.39184053
12Segmental peripheral demyelination/remyelination (HP:0003481)4.37271710
13Degeneration of the lateral corticospinal tracts (HP:0002314)4.27648356
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.27648356
15Hyperglycinemia (HP:0002154)3.63564253
16Absent/shortened dynein arms (HP:0200106)3.61829476
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.61829476
18Bronchiectasis (HP:0002110)3.51306804
19Peripheral hypomyelination (HP:0007182)3.48353679
20Hyperglycinuria (HP:0003108)3.43749997
21Chronic bronchitis (HP:0004469)3.42516583
22Back pain (HP:0003418)3.37588235
23Abnormality of the corticospinal tract (HP:0002492)3.36724648
24Abnormality of glycine metabolism (HP:0010895)3.36293331
25Abnormality of serine family amino acid metabolism (HP:0010894)3.36293331
26Postural tremor (HP:0002174)3.26773286
27Male infertility (HP:0003251)3.18993152
28Increased CSF protein (HP:0002922)3.15657029
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12199500
30Nasal polyposis (HP:0100582)2.98385174
31Urinary urgency (HP:0000012)2.89398394
32Acute myeloid leukemia (HP:0004808)2.82028535
33Pancreatic fibrosis (HP:0100732)2.81491054
34Chromsome breakage (HP:0040012)2.79151440
35Median cleft lip (HP:0000161)2.76345484
36Impaired proprioception (HP:0010831)2.63027767
37Foot dorsiflexor weakness (HP:0009027)2.53616719
38Syringomyelia (HP:0003396)2.53072131
39Spinal cord lesions (HP:0100561)2.53072131
40Inappropriate behavior (HP:0000719)2.52582284
41True hermaphroditism (HP:0010459)2.49609583
42Chronic hepatic failure (HP:0100626)2.49331700
43Congenital, generalized hypertrichosis (HP:0004540)2.46521284
44Macroorchidism (HP:0000053)2.44207217
45Progressive external ophthalmoplegia (HP:0000590)2.42826951
46Onion bulb formation (HP:0003383)2.42067669
47Deep philtrum (HP:0002002)2.39671951
48Abnormality of the fingertips (HP:0001211)2.38359143
49Hammertoe (HP:0001765)2.37741658
50Abnormality of the foot musculature (HP:0001436)2.35593790
51Sparse lateral eyebrow (HP:0005338)2.34947196
52Supranuclear gaze palsy (HP:0000605)2.33425827
53Abnormality of the nasal mucosa (HP:0000433)2.32698461
54Progressive muscle weakness (HP:0003323)2.30533558
55Subacute progressive viral hepatitis (HP:0006572)2.27853225
56Fatigue (HP:0012378)2.27673276
57Steppage gait (HP:0003376)2.27171827
58Short middle phalanx of the 5th finger (HP:0004220)2.24819301
59Prominent nose (HP:0000448)2.23485586
60Submucous cleft hard palate (HP:0000176)2.23030865
61Abnormality of binocular vision (HP:0011514)2.21216290
62Diplopia (HP:0000651)2.21216290
63Subaortic stenosis (HP:0001682)2.18541274
64Abnormality of the left ventricular outflow tract (HP:0011103)2.18541274
65Microglossia (HP:0000171)2.18496739
66Viral hepatitis (HP:0006562)2.16393265
67Bile duct proliferation (HP:0001408)2.14691927
68Abnormal biliary tract physiology (HP:0012439)2.14691927
69Recurrent viral infections (HP:0004429)2.13505595
70Recurrent sinusitis (HP:0011108)2.12885454
71Gonadotropin excess (HP:0000837)2.11233911
72Myelodysplasia (HP:0002863)2.10363881
73Nemaline bodies (HP:0003798)2.10010870
74Occipital encephalocele (HP:0002085)2.09924805
75Restlessness (HP:0000711)2.08174153
76Myelomeningocele (HP:0002475)2.06813464
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.06689726
78Osteolytic defects of the hand bones (HP:0009699)2.06689726
79Reduced subcutaneous adipose tissue (HP:0003758)2.06429979
80Infertility (HP:0000789)2.04790672
81Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.02779279
82Tetraparesis (HP:0002273)2.01859315
83Muscle fiber inclusion bodies (HP:0100299)2.00763451
84Glucose intolerance (HP:0000833)1.99822646
85Cafe-au-lait spot (HP:0000957)1.98728613
86Long eyelashes (HP:0000527)1.98703497
87Pili torti (HP:0003777)1.98181048
88Neurofibrillary tangles (HP:0002185)1.97371554
89Hemiplegia (HP:0002301)1.96956652
90Atelectasis (HP:0100750)1.95076996
91Decreased motor nerve conduction velocity (HP:0003431)1.93601811
92Impaired vibratory sensation (HP:0002495)1.92910735
93Chronic sinusitis (HP:0011109)1.92501779
94Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.92168157
95Ankyloglossia (HP:0010296)1.90823365
96Resting tremor (HP:0002322)1.89647000
97Dysmetric saccades (HP:0000641)1.89522950
98Confusion (HP:0001289)1.88623434
99Asymmetry of the thorax (HP:0001555)1.87917281
100Congenital hepatic fibrosis (HP:0002612)1.87758242
101Increased density of long bones (HP:0006392)1.86857831
102Facial cleft (HP:0002006)1.85829697
103Intellectual disability, moderate (HP:0002342)1.84673377
104Absent frontal sinuses (HP:0002688)1.84122605
105Autoimmune hemolytic anemia (HP:0001890)1.83751794
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.83063782
107Abnormality of chromosome stability (HP:0003220)1.82958102
108Urinary bladder sphincter dysfunction (HP:0002839)1.82219440
109Flat acetabular roof (HP:0003180)1.81710563
110Impaired vibration sensation in the lower limbs (HP:0002166)1.81281410
111Abnormal umbilical cord blood vessels (HP:0011403)1.80206597
112Single umbilical artery (HP:0001195)1.80206597
113Abnormality of the fetal cardiovascular system (HP:0010948)1.80206597
114Basal cell carcinoma (HP:0002671)1.80178102
115Medulloblastoma (HP:0002885)1.79550628
116Progressive hearing impairment (HP:0001730)1.79203022
117Anencephaly (HP:0002323)1.77127621
118Vascular tortuosity (HP:0004948)1.76979474
119Colitis (HP:0002583)1.76608818
120Megalencephaly (HP:0001355)1.75386014
121Entropion (HP:0000621)1.75052072
122Dyschromatopsia (HP:0007641)1.74821375
123Short nail (HP:0001799)1.74733932
124Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.74564300
125Sandal gap (HP:0001852)1.73105956
126Abnormality of oral frenula (HP:0000190)1.73056914
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.71199681
128Abnormal foot bone ossification (HP:0010675)1.70955791
129Cone-rod dystrophy (HP:0000548)1.70635915
130Ectopic anus (HP:0004397)1.70600032
131Fibular hypoplasia (HP:0003038)1.70231585
132Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.70069492
133Poikilocytosis (HP:0004447)1.69954212
134Abdominal situs inversus (HP:0003363)1.69079691
135Abnormality of abdominal situs (HP:0011620)1.69079691
136Exercise-induced myalgia (HP:0003738)1.68901270
137Urinary incontinence (HP:0000020)1.68497815
138Increased connective tissue (HP:0009025)1.68430414
139Follicular hyperkeratosis (HP:0007502)1.67327646
140Hemiparesis (HP:0001269)1.67278687
141Peripheral demyelination (HP:0011096)1.63846774
142Morphological abnormality of the pyramidal tract (HP:0002062)1.63387948
143Abnormality of lateral ventricle (HP:0030047)1.62932013
144Abnormality of the distal phalanges of the toes (HP:0010182)1.62718198
145Apathy (HP:0000741)1.60729690
146Missing ribs (HP:0000921)1.59589971
147Pachygyria (HP:0001302)1.59560509
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59430096
149Spastic diplegia (HP:0001264)1.59142442
150Bowel incontinence (HP:0002607)1.58844522
151Spondylolisthesis (HP:0003302)1.58359434
152Tubulointerstitial nephritis (HP:0001970)1.58235148
153Menstrual irregularities (HP:0000858)1.57333130
154Birth length less than 3rd percentile (HP:0003561)1.57286570
155Abnormality of the thoracic spine (HP:0100711)1.56962361
156Aortic aneurysm (HP:0004942)1.56571527
157Cystic hygroma (HP:0000476)1.56228536
158Heterotopia (HP:0002282)1.55902120
159Squamous cell carcinoma (HP:0002860)1.55741116
160Malignant hyperthermia (HP:0002047)1.55624955
161Recurrent bronchitis (HP:0002837)1.55256791
162Bronchitis (HP:0012387)1.55148963
163Recurrent otitis media (HP:0000403)1.54802366
164Broad face (HP:0000283)1.54595058
165Abnormality of the axillary hair (HP:0100134)1.53353049
166Abnormality of secondary sexual hair (HP:0009888)1.53353049
167Cerebral inclusion bodies (HP:0100314)1.53244557
168Lower limb muscle weakness (HP:0007340)1.53172361
169Upper limb muscle weakness (HP:0003484)1.52704005
170Acute lymphatic leukemia (HP:0006721)1.52012187
171Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.51745998
172Osteomyelitis (HP:0002754)1.50887969
173Dislocated radial head (HP:0003083)1.49834902
174Central scotoma (HP:0000603)1.49670588
175Distal lower limb amyotrophy (HP:0008944)1.49180867
176Ulnar bowing (HP:0003031)1.46669286
177Abnormality of the frontal sinuses (HP:0002687)1.45399582
178Long palpebral fissure (HP:0000637)1.44681806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.41446394
2EIF2AK14.21338005
3TRIB33.97298296
4PRPF4B3.79286494
5CDK123.23158718
6EIF2AK32.94619600
7PNCK2.84658412
8MKNK22.82042635
9LIMK12.72704635
10BRD42.50303725
11MAP2K32.32903055
12LRRK22.32839641
13TTK2.23762557
14MST1R2.22974706
15NTRK12.21890299
16BLK2.21724639
17STK392.20003847
18STK102.10608709
19ARAF1.99086805
20NEK91.95797598
21MAPK151.95392994
22SMG11.93025338
23MAP3K141.92535938
24EEF2K1.90404719
25NEK11.87192892
26SCYL21.85101546
27PAK31.83447205
28MKNK11.82683178
29IRAK31.75328505
30ICK1.73694271
31ROCK21.73568133
32CDK61.72280597
33MAP3K101.68123500
34LMTK21.62749628
35BRSK21.61419822
36PBK1.58934665
37MAP3K21.53313242
38KSR21.47956970
39PKN11.42939894
40TSSK61.41117162
41WNK41.38890997
42EPHB11.38413376
43PTK2B1.34634586
44PIM21.31329651
45CDK41.30577272
46SRPK11.27245162
47MELK1.26033240
48CLK11.23926519
49PTK61.21678594
50WNK11.20396541
51RET1.19497718
52IRAK21.17733579
53MAP3K61.16045713
54CDC71.15849581
55PDK21.14706062
56FGFR31.13257410
57PLK41.12891221
58TAOK21.12679592
59CDK81.08194708
60ROCK11.05992100
61PRKD11.03152002
62PRKCH1.02748144
63GSK3A1.01883117
64PRKCE1.00499618
65TTN0.99354099
66TRPM70.98752470
67PKN20.97646751
68RIPK40.96960099
69RIPK10.95052643
70CDC42BPA0.94965132
71MAP3K30.94877465
72ITK0.94321632
73MAPK130.94316177
74TYRO30.93720790
75MTOR0.92171170
76BUB10.90679922
77NEK60.89277423
78SIK30.89250003
79MAP3K130.89112327
80CHEK20.87529781
81MAP2K20.83494321
82PRKCQ0.83367834
83YES10.82962515
84ILK0.82774473
85GRK10.81977426
86JAK10.81830136
87EPHA20.81126729
88LATS10.80490177
89MAP2K10.79784824
90FES0.78357335
91MAP3K80.78274206
92PTK20.78267147
93RPS6KB20.77795621
94RAF10.75230613
95LATS20.74626359
96MAPK110.74479888
97PRKCG0.74127816
98BRSK10.72272393
99MAPK120.71041513
100DAPK20.69633294
101ERBB40.69242615
102RPS6KA20.68956341
103IRAK40.68803879
104PHKG20.68040558
105PHKG10.68040558
106ERBB30.68022528
107ZAP700.67941285
108BMPR20.67469968
109CHEK10.67184867
110BMX0.67183390
111ALK0.67154904
112PIK3CA0.66978612
113ABL20.65524951
114CDK90.65072040
115TBK10.65002632
116FYN0.63231087
117FGFR20.62720742
118TYK20.62593783
119INSR0.62404243
120EIF2AK20.62111665
121AURKB0.61806388
122MINK10.61313112
123ATR0.61286310
124STK40.60870241
125PDPK10.60704087
126MUSK0.60671074
127PRKG20.60169310
128PRKD20.60132306
129DYRK1A0.58102311
130MAP3K70.57143047
131MAP3K50.56639871
132PDGFRB0.55962918
133CSK0.55143405
134PRKG10.54992901
135RPS6KB10.54837567
136SIK10.54823270
137ERN10.54390946
138PIM10.54347285
139PAK60.53309181
140UHMK10.53296622
141PAK20.52913533
142SGK2230.52756937
143SGK4940.52756937
144CCNB10.52543314
145CAMK1D0.51083795
146PAK40.50846431
147CDK70.50829269
148PRKD30.50105926
149FER0.49673083
150CDK50.48846522
151MAPKAPK20.48172999
152SRC0.47901628
153PRKCI0.47772156
154PDGFRA0.46488049
155PAK10.46446591
156PLK10.46020362
157CAMK1G0.45823403
158AKT30.44617325
159GRK60.44354331
160CDK30.43763364
161PDK10.43665138
162PRKAA20.41841978
163CSNK1E0.41337649
164NEK20.40990326
165LCK0.40602560
166CAMK2B0.38728409
167KSR10.38429869
168PRKDC0.38283824
169BTK0.37650451
170WEE10.36702525
171MET0.36397937
172CDK20.35504231
173MAP4K10.34761495
174SGK30.34058536
175ADRBK10.34047615
176HCK0.33389842
177MAP3K10.33385292
178CDK10.33200608
179NME20.32503827

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002325.05368028
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.76688283
3Nitrogen metabolism_Homo sapiens_hsa009104.47676514
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.07304248
5Non-homologous end-joining_Homo sapiens_hsa034502.73975466
6Vitamin B6 metabolism_Homo sapiens_hsa007502.51171870
7Chronic myeloid leukemia_Homo sapiens_hsa052202.36511271
8Cell cycle_Homo sapiens_hsa041102.18771763
9DNA replication_Homo sapiens_hsa030302.11335951
10Pancreatic cancer_Homo sapiens_hsa052122.03744156
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02105770
12Propanoate metabolism_Homo sapiens_hsa006401.98385375
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93877623
14Non-small cell lung cancer_Homo sapiens_hsa052231.90348936
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85559210
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83288032
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.82331193
18PPAR signaling pathway_Homo sapiens_hsa033201.81539052
19Hepatitis B_Homo sapiens_hsa051611.80649367
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80092893
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79524148
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77315658
23Acute myeloid leukemia_Homo sapiens_hsa052211.66974433
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64648590
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63105729
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60238482
27Mismatch repair_Homo sapiens_hsa034301.59312254
28Butanoate metabolism_Homo sapiens_hsa006501.56421147
29Arginine and proline metabolism_Homo sapiens_hsa003301.50133452
30Influenza A_Homo sapiens_hsa051641.49483412
31Measles_Homo sapiens_hsa051621.49034385
32Bladder cancer_Homo sapiens_hsa052191.44494317
33mRNA surveillance pathway_Homo sapiens_hsa030151.40997496
34Histidine metabolism_Homo sapiens_hsa003401.40704538
35Spliceosome_Homo sapiens_hsa030401.39642434
36MicroRNAs in cancer_Homo sapiens_hsa052061.39588774
37Arginine biosynthesis_Homo sapiens_hsa002201.39246210
38Chemical carcinogenesis_Homo sapiens_hsa052041.37125358
39Nucleotide excision repair_Homo sapiens_hsa034201.36781786
40Apoptosis_Homo sapiens_hsa042101.36462323
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35727563
42RNA transport_Homo sapiens_hsa030131.34282100
43Viral carcinogenesis_Homo sapiens_hsa052031.34112942
44Herpes simplex infection_Homo sapiens_hsa051681.32015377
45Colorectal cancer_Homo sapiens_hsa052101.31022978
46p53 signaling pathway_Homo sapiens_hsa041151.30669461
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25832885
48Osteoclast differentiation_Homo sapiens_hsa043801.21008774
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20037214
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18065649
51TNF signaling pathway_Homo sapiens_hsa046681.17904089
52Endometrial cancer_Homo sapiens_hsa052131.17044353
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.16416342
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14582014
55Bile secretion_Homo sapiens_hsa049761.13983674
56Tight junction_Homo sapiens_hsa045301.13826316
57FoxO signaling pathway_Homo sapiens_hsa040681.13656834
58Thyroid cancer_Homo sapiens_hsa052161.13071626
59HTLV-I infection_Homo sapiens_hsa051661.12110087
60Epstein-Barr virus infection_Homo sapiens_hsa051691.11736365
61Hepatitis C_Homo sapiens_hsa051601.09733625
62Fatty acid degradation_Homo sapiens_hsa000711.09515590
63Fanconi anemia pathway_Homo sapiens_hsa034601.08910797
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08242574
65Long-term depression_Homo sapiens_hsa047301.07901339
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06285955
67mTOR signaling pathway_Homo sapiens_hsa041501.06248566
68Legionellosis_Homo sapiens_hsa051341.05609267
69Steroid biosynthesis_Homo sapiens_hsa001001.04222009
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03368746
71Leishmaniasis_Homo sapiens_hsa051401.01716311
72* Jak-STAT signaling pathway_Homo sapiens_hsa046300.99558535
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.99466605
74Toxoplasmosis_Homo sapiens_hsa051450.98718992
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.96187228
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.96091922
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94674999
78Other glycan degradation_Homo sapiens_hsa005110.94203315
79T cell receptor signaling pathway_Homo sapiens_hsa046600.94189988
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92572811
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91611211
82Prolactin signaling pathway_Homo sapiens_hsa049170.89715990
83Mineral absorption_Homo sapiens_hsa049780.88625819
84ErbB signaling pathway_Homo sapiens_hsa040120.87383037
85Phenylalanine metabolism_Homo sapiens_hsa003600.86828075
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86814437
87Choline metabolism in cancer_Homo sapiens_hsa052310.86246036
88Hippo signaling pathway_Homo sapiens_hsa043900.86121957
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85921760
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85188108
91Fatty acid metabolism_Homo sapiens_hsa012120.82231385
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81856293
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81388953
94Ether lipid metabolism_Homo sapiens_hsa005650.81134235
95Pentose phosphate pathway_Homo sapiens_hsa000300.81062365
96Glutamatergic synapse_Homo sapiens_hsa047240.79470137
97Lysine degradation_Homo sapiens_hsa003100.79397231
98Sphingolipid metabolism_Homo sapiens_hsa006000.79367980
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78937003
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78925164
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78146158
102Estrogen signaling pathway_Homo sapiens_hsa049150.77778982
103Tuberculosis_Homo sapiens_hsa051520.76137745
104Focal adhesion_Homo sapiens_hsa045100.76113926
105Circadian rhythm_Homo sapiens_hsa047100.75606555
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74853120
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74506049
108Complement and coagulation cascades_Homo sapiens_hsa046100.72859439
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72422365
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72128173
111Inositol phosphate metabolism_Homo sapiens_hsa005620.72067929
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71963878
113Prion diseases_Homo sapiens_hsa050200.71273932
114Malaria_Homo sapiens_hsa051440.70875361
115Pyruvate metabolism_Homo sapiens_hsa006200.70270180
116Hematopoietic cell lineage_Homo sapiens_hsa046400.70234056
117Insulin resistance_Homo sapiens_hsa049310.69491187
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69088518
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68343026
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68181560
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66278929
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.64621930
123HIF-1 signaling pathway_Homo sapiens_hsa040660.64315318
124Renal cell carcinoma_Homo sapiens_hsa052110.63684502
125Platelet activation_Homo sapiens_hsa046110.63436980
126Glycerolipid metabolism_Homo sapiens_hsa005610.62636857
127Insulin signaling pathway_Homo sapiens_hsa049100.62488693
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62463281
129Gastric acid secretion_Homo sapiens_hsa049710.62376298
130Tyrosine metabolism_Homo sapiens_hsa003500.61904133
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61704506
132Axon guidance_Homo sapiens_hsa043600.61621760
133Cholinergic synapse_Homo sapiens_hsa047250.60551243
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60208514
135Dopaminergic synapse_Homo sapiens_hsa047280.59856150
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59610108
137Viral myocarditis_Homo sapiens_hsa054160.58577216
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58399510
139Thyroid hormone synthesis_Homo sapiens_hsa049180.57482647
140Huntingtons disease_Homo sapiens_hsa050160.57106744
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56713573
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56313553
143Fatty acid biosynthesis_Homo sapiens_hsa000610.55274260
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.54218417
145Pyrimidine metabolism_Homo sapiens_hsa002400.52934572
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52929843
147Pathways in cancer_Homo sapiens_hsa052000.52558858
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52046200
149One carbon pool by folate_Homo sapiens_hsa006700.50806804
150Melanogenesis_Homo sapiens_hsa049160.50351927
151Ovarian steroidogenesis_Homo sapiens_hsa049130.49907592
152VEGF signaling pathway_Homo sapiens_hsa043700.48711995
153TGF-beta signaling pathway_Homo sapiens_hsa043500.48550477
154Notch signaling pathway_Homo sapiens_hsa043300.47904665
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47733921
156Shigellosis_Homo sapiens_hsa051310.47541499
157Proteoglycans in cancer_Homo sapiens_hsa052050.47087456
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.46945844
159ECM-receptor interaction_Homo sapiens_hsa045120.46229127
160Glioma_Homo sapiens_hsa052140.45555610
161Prostate cancer_Homo sapiens_hsa052150.45212103
162Melanoma_Homo sapiens_hsa052180.45166153
163GnRH signaling pathway_Homo sapiens_hsa049120.44225730
164Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41261837
165Graft-versus-host disease_Homo sapiens_hsa053320.40175203
166Dorso-ventral axis formation_Homo sapiens_hsa043200.38726769
167Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36902812
168SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36848606
169Adherens junction_Homo sapiens_hsa045200.36484370
170Biosynthesis of amino acids_Homo sapiens_hsa012300.36354499
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.36093767
172Glutathione metabolism_Homo sapiens_hsa004800.35364417
1732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34075432
174Small cell lung cancer_Homo sapiens_hsa052220.32883342
175Serotonergic synapse_Homo sapiens_hsa047260.31781758
176Rap1 signaling pathway_Homo sapiens_hsa040150.31059523
177Cardiac muscle contraction_Homo sapiens_hsa042600.30679399
178B cell receptor signaling pathway_Homo sapiens_hsa046620.30569056
179cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28288896
180Peroxisome_Homo sapiens_hsa041460.28258489
181beta-Alanine metabolism_Homo sapiens_hsa004100.27119227
182Tryptophan metabolism_Homo sapiens_hsa003800.27096002

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