CNTLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.59583220
2behavioral response to nicotine (GO:0035095)5.27711347
3kinetochore organization (GO:0051383)4.65998157
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.60820179
5definitive hemopoiesis (GO:0060216)4.41126868
6regulation of meiosis I (GO:0060631)4.29709648
7heparin metabolic process (GO:0030202)4.24577959
8heparin biosynthetic process (GO:0030210)4.24577959
9kidney morphogenesis (GO:0060993)4.11331385
10metanephric mesenchyme development (GO:0072075)4.11034881
11replication fork processing (GO:0031297)4.02009225
12cilium or flagellum-dependent cell motility (GO:0001539)3.98368670
13centriole replication (GO:0007099)3.94895486
14response to pheromone (GO:0019236)3.93361258
15regulation of DNA endoreduplication (GO:0032875)3.89435864
16kinetochore assembly (GO:0051382)3.89050453
17mitotic chromosome condensation (GO:0007076)3.86982879
18DNA double-strand break processing (GO:0000729)3.84716974
19DNA ligation (GO:0006266)3.83773422
20piRNA metabolic process (GO:0034587)3.75348985
21kidney mesenchyme development (GO:0072074)3.72915709
22histone H3-K9 methylation (GO:0051567)3.72084826
23regulation of sister chromatid cohesion (GO:0007063)3.68472537
24double-strand break repair via homologous recombination (GO:0000724)3.67971554
25recombinational repair (GO:0000725)3.64901542
26sister chromatid segregation (GO:0000819)3.56520736
27cell proliferation in forebrain (GO:0021846)3.56443902
28attachment of spindle microtubules to kinetochore (GO:0008608)3.53220382
29sister chromatid cohesion (GO:0007062)3.50177364
30tryptophan catabolic process (GO:0006569)3.48686889
31indole-containing compound catabolic process (GO:0042436)3.48686889
32indolalkylamine catabolic process (GO:0046218)3.48686889
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.43534738
34indolalkylamine metabolic process (GO:0006586)3.38074758
35protein polyglutamylation (GO:0018095)3.34598320
36positive regulation of meiosis (GO:0045836)3.34361972
37interkinetic nuclear migration (GO:0022027)3.32972664
38CENP-A containing nucleosome assembly (GO:0034080)3.27566849
39regulation of non-canonical Wnt signaling pathway (GO:2000050)3.26031362
40histone H3-K9 modification (GO:0061647)3.22582743
41axonemal dynein complex assembly (GO:0070286)3.22506257
42megakaryocyte development (GO:0035855)3.20691619
43mitotic sister chromatid segregation (GO:0000070)3.20151954
44protein localization to kinetochore (GO:0034501)3.19661402
45sulfation (GO:0051923)3.19407311
46regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.18996204
47protein K6-linked ubiquitination (GO:0085020)3.15137250
48glomerulus development (GO:0032835)3.14280597
49positive regulation of mitotic sister chromatid separation (GO:1901970)3.13448698
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13448698
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13448698
52protein localization to chromosome, centromeric region (GO:0071459)3.13306293
53chromatin remodeling at centromere (GO:0031055)3.11349045
54somite development (GO:0061053)3.09817384
55behavioral response to ethanol (GO:0048149)3.09745247
56negative regulation of DNA-dependent DNA replication (GO:2000104)3.06885939
57meiotic chromosome segregation (GO:0045132)3.06669161
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06033900
59positive regulation of meiotic cell cycle (GO:0051446)3.05843324
60regulation of mesoderm development (GO:2000380)3.03196445
61otic vesicle formation (GO:0030916)3.02091078
62water-soluble vitamin biosynthetic process (GO:0042364)3.01696652
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00294457
64regulation of female gonad development (GO:2000194)2.99321033
65resolution of meiotic recombination intermediates (GO:0000712)2.99001369
66centriole assembly (GO:0098534)2.98992410
67histone exchange (GO:0043486)2.98940359
68male meiosis I (GO:0007141)2.98438111
69DNA deamination (GO:0045006)2.97633158
70protein neddylation (GO:0045116)2.97243878
71mitotic recombination (GO:0006312)2.95104470
72cytoplasmic mRNA processing body assembly (GO:0033962)2.94387291
73regulation of gene silencing by RNA (GO:0060966)2.94122113
74regulation of posttranscriptional gene silencing (GO:0060147)2.94122113
75regulation of gene silencing by miRNA (GO:0060964)2.94122113
76pericardium development (GO:0060039)2.93453612
77synapsis (GO:0007129)2.92142383
78tryptophan metabolic process (GO:0006568)2.91525636
79DNA methylation involved in gamete generation (GO:0043046)2.89136561
80neural tube formation (GO:0001841)2.87125475
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.85763199
82intra-S DNA damage checkpoint (GO:0031573)2.82989670
83negative regulation of stem cell proliferation (GO:2000647)2.81539069
84DNA replication-independent nucleosome assembly (GO:0006336)2.80745246
85DNA replication-independent nucleosome organization (GO:0034724)2.80745246
86negative regulation of translation, ncRNA-mediated (GO:0040033)2.79246827
87regulation of translation, ncRNA-mediated (GO:0045974)2.79246827
88negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79246827
89histone H2A acetylation (GO:0043968)2.79214060
90kynurenine metabolic process (GO:0070189)2.77905685
91limb bud formation (GO:0060174)2.77030054
92telomere maintenance via recombination (GO:0000722)2.75599346
93detection of light stimulus involved in visual perception (GO:0050908)2.75150763
94detection of light stimulus involved in sensory perception (GO:0050962)2.75150763
95DNA packaging (GO:0006323)2.74848541
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.72465919
97left/right axis specification (GO:0070986)2.71611057
98microtubule depolymerization (GO:0007019)2.71482122
99gamma-aminobutyric acid transport (GO:0015812)2.70912478
100DNA unwinding involved in DNA replication (GO:0006268)2.68188652
101DNA replication checkpoint (GO:0000076)2.67164284
102negative regulation of systemic arterial blood pressure (GO:0003085)2.65913151
103regulation of rhodopsin mediated signaling pathway (GO:0022400)2.65629384
104* centrosome organization (GO:0051297)2.64504215
105protein localization to cilium (GO:0061512)2.63993270
106adaptation of signaling pathway (GO:0023058)2.63508690
107translesion synthesis (GO:0019985)2.62538945
108L-fucose catabolic process (GO:0042355)2.61213818
109fucose catabolic process (GO:0019317)2.61213818
110L-fucose metabolic process (GO:0042354)2.61213818
111head development (GO:0060322)2.60481055
112platelet dense granule organization (GO:0060155)2.59129683
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.58776125
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.58776125
115chromosome condensation (GO:0030261)2.57525143
116intraciliary transport (GO:0042073)2.57521923
117dermatan sulfate biosynthetic process (GO:0030208)2.56990859
118negative regulation of telomere maintenance (GO:0032205)2.56180751
119cornea development in camera-type eye (GO:0061303)2.55409756
120nonmotile primary cilium assembly (GO:0035058)2.54876481
121protein localization to chromosome (GO:0034502)2.54678206
122chromosome organization involved in meiosis (GO:0070192)2.54667176
123reciprocal meiotic recombination (GO:0007131)2.54551710
124reciprocal DNA recombination (GO:0035825)2.54551710
125RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54516206
126mesenchymal-epithelial cell signaling (GO:0060638)2.54302806
127* microtubule organizing center organization (GO:0031023)2.53983207
128regulation of spindle organization (GO:0090224)2.53736149
129rRNA catabolic process (GO:0016075)2.53540570
130regulation of hippo signaling (GO:0035330)2.53420769
131male meiosis (GO:0007140)2.52820377
132glucocorticoid receptor signaling pathway (GO:0042921)2.52536549
133appendage development (GO:0048736)2.51976699
134limb development (GO:0060173)2.51976699
135positive regulation of male gonad development (GO:2000020)2.51973696
136sperm motility (GO:0030317)2.51169381
137microtubule anchoring (GO:0034453)2.51036410
138rhodopsin mediated signaling pathway (GO:0016056)2.50996225
139DNA synthesis involved in DNA repair (GO:0000731)2.50902790
140negative regulation of mast cell activation (GO:0033004)2.50217779
141nuclear pore complex assembly (GO:0051292)2.49139587
142somite rostral/caudal axis specification (GO:0032525)2.49124384
143metaphase plate congression (GO:0051310)2.48845766
144protein complex biogenesis (GO:0070271)2.48777970
145indole-containing compound metabolic process (GO:0042430)2.47448915
146insulin-like growth factor receptor signaling pathway (GO:0048009)2.47403562
147negative regulation of astrocyte differentiation (GO:0048712)2.47154509
148meiotic cell cycle (GO:0051321)2.46854644
149ATP-dependent chromatin remodeling (GO:0043044)2.46667730
150DNA duplex unwinding (GO:0032508)2.45486212
151response to X-ray (GO:0010165)2.44183431
152DNA geometric change (GO:0032392)2.43510199
153genitalia morphogenesis (GO:0035112)2.43500269
154embryonic hemopoiesis (GO:0035162)2.43303132
155regulation of male gonad development (GO:2000018)2.43060135
156mesonephros development (GO:0001823)2.42671233
157hematopoietic stem cell proliferation (GO:0071425)2.42551556
158regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.42047248
159DNA conformation change (GO:0071103)2.41862170
160cilium movement (GO:0003341)2.40543951
161spindle checkpoint (GO:0031577)2.38516853
162lymph vessel development (GO:0001945)2.37622765
163alternative mRNA splicing, via spliceosome (GO:0000380)2.35729398
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35202635
165blood vessel maturation (GO:0001955)2.34527583
166dermatan sulfate metabolic process (GO:0030205)2.34451911
167replicative senescence (GO:0090399)2.33910417
168regulation of mitotic metaphase/anaphase transition (GO:0030071)2.33685932
169DNA topological change (GO:0006265)2.32644365
170DNA strand elongation involved in DNA replication (GO:0006271)2.32359111
171chromosome organization (GO:0051276)2.31115995
172regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.30594953
173regulation of sister chromatid segregation (GO:0033045)2.29691926
174regulation of mitotic sister chromatid separation (GO:0010965)2.29691926
175regulation of mitotic sister chromatid segregation (GO:0033047)2.29691926
176regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.29435252
177centrosome duplication (GO:0051298)2.29045951
178epithelial cilium movement (GO:0003351)2.28546179
179positive regulation of cell cycle G2/M phase transition (GO:1902751)2.27796915
180positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.27796915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.69062031
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.90089738
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.85090154
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.07577830
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07111526
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.98522997
7IGF1R_20145208_ChIP-Seq_DFB_Human2.77636057
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.58064964
9VDR_22108803_ChIP-Seq_LS180_Human2.57343052
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.54168327
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.53514640
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48236115
13SCL_19346495_ChIP-Seq_HPC-7_Human2.38655647
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29286261
15EWS_26573619_Chip-Seq_HEK293_Human2.16783055
16HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.15814706
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13562432
18FUS_26573619_Chip-Seq_HEK293_Human2.11359435
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02872986
20GBX2_23144817_ChIP-Seq_PC3_Human2.02537364
21IRF1_19129219_ChIP-ChIP_H3396_Human1.96709153
22AR_21909140_ChIP-Seq_LNCAP_Human1.92971862
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87897810
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.81478166
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.78560406
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.77541581
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.75482474
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72896681
29EZH2_22144423_ChIP-Seq_EOC_Human1.72524378
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.70909120
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67859232
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67859232
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67720840
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65571408
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65184042
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63450028
37ZNF274_21170338_ChIP-Seq_K562_Hela1.62982915
38* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62313382
39* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59913884
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56043579
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.53761045
42BCAT_22108803_ChIP-Seq_LS180_Human1.53310587
43TAF15_26573619_Chip-Seq_HEK293_Human1.49964481
44TP53_16413492_ChIP-PET_HCT116_Human1.47403477
45P300_19829295_ChIP-Seq_ESCs_Human1.45515327
46* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44914997
47CBP_20019798_ChIP-Seq_JUKART_Human1.42176702
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42176702
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40470032
50MYC_18940864_ChIP-ChIP_HL60_Human1.39725165
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39651090
52SMAD4_21799915_ChIP-Seq_A2780_Human1.38563370
53* STAT3_23295773_ChIP-Seq_U87_Human1.37950135
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36380030
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34726251
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32567447
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31068427
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30889822
59SOX2_19829295_ChIP-Seq_ESCs_Human1.27285214
60NANOG_19829295_ChIP-Seq_ESCs_Human1.27285214
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27241618
62TCF4_22108803_ChIP-Seq_LS180_Human1.27032896
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25907463
64* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24854538
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22078030
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.21777201
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21542745
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21387548
69* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20355378
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19600790
71* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16200207
72RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15358347
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.14961043
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14243828
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14156552
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.14156552
77AR_21572438_ChIP-Seq_LNCaP_Human1.13984770
78RNF2_27304074_Chip-Seq_NSC_Mouse1.13678599
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13025698
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12949457
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10848580
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10770745
83* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10148987
84* TCF4_23295773_ChIP-Seq_U87_Human1.09595565
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09529225
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09231311
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08167470
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.07955943
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.07570047
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06620676
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.06467694
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.06464552
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.06144027
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05394608
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04800134
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04798585
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.04164940
98ELK1_19687146_ChIP-ChIP_HELA_Human1.03926582
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02391038
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.02346317
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02288382
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02046529
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.01697700
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01413517
105ER_23166858_ChIP-Seq_MCF-7_Human1.01297515
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.00988792
107EZH2_27304074_Chip-Seq_ESCs_Mouse1.00963358
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00170279
109BRD4_25478319_ChIP-Seq_HGPS_Human0.99756358
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.99461909
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99319478
112CDX2_22108803_ChIP-Seq_LS180_Human0.98992764
113P53_22387025_ChIP-Seq_ESCs_Mouse0.98792649
114TCF4_18268006_ChIP-ChIP_LS174T_Human0.98224327
115YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98136285
116TP53_22573176_ChIP-Seq_HFKS_Human0.98112747
117OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98111265
118CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97933413
119TP53_18474530_ChIP-ChIP_U2OS_Human0.97665336
120GF1B_26923725_Chip-Seq_HPCs_Mouse0.95355374
121* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95119328
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94918553
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94842377
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94725330
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94411489
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94165341
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.89583212
128JUN_21703547_ChIP-Seq_K562_Human0.89133565
129RUNX2_22187159_ChIP-Seq_PCA_Human0.88567326
130* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87616089
131TAL1_26923725_Chip-Seq_HPCs_Mouse0.86953022
132* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86900507
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85788672
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85771374
135* AR_25329375_ChIP-Seq_VCAP_Human0.84655632
136BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84200132
137STAT3_18555785_Chip-Seq_ESCs_Mouse0.82970424
138* RNF2_27304074_Chip-Seq_ESCs_Mouse0.82731083
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82612179
140JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81625480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.21809818
2MP0002837_dystrophic_cardiac_calcinosis4.09485534
3MP0008057_abnormal_DNA_replication3.15688404
4MP0008877_abnormal_DNA_methylation3.06730911
5MP0005503_abnormal_tendon_morphology2.82909983
6MP0003121_genomic_imprinting2.82888330
7MP0003122_maternal_imprinting2.68101591
8MP0006054_spinal_hemorrhage2.62986678
9MP0000569_abnormal_digit_pigmentation2.61194964
10MP0008438_abnormal_cutaneous_collagen2.56789783
11MP0003787_abnormal_imprinting2.48524706
12MP0010094_abnormal_chromosome_stability2.44295170
13MP0003136_yellow_coat_color2.37276364
14MP0003123_paternal_imprinting2.23250246
15MP0005551_abnormal_eye_electrophysiolog2.22864216
16MP0001188_hyperpigmentation2.22597680
17MP0010368_abnormal_lymphatic_system2.21054152
18MP0002938_white_spotting2.17854129
19MP0003195_calcinosis2.06898398
20MP0004808_abnormal_hematopoietic_stem2.03377158
21MP0002009_preneoplasia2.00892917
22MP0003943_abnormal_hepatobiliary_system1.96518157
23MP0009278_abnormal_bone_marrow1.93673646
24MP0009250_abnormal_appendicular_skeleto1.87204800
25MP0002653_abnormal_ependyma_morphology1.86217176
26MP0005174_abnormal_tail_pigmentation1.75184687
27MP0001485_abnormal_pinna_reflex1.74951910
28MP0003942_abnormal_urinary_system1.74676376
29MP0003890_abnormal_embryonic-extraembry1.74299571
30MP0004885_abnormal_endolymph1.74146796
31MP0008007_abnormal_cellular_replicative1.70719543
32MP0001879_abnormal_lymphatic_vessel1.68519964
33MP0002396_abnormal_hematopoietic_system1.68451802
34MP0000733_abnormal_muscle_development1.68352482
35MP0004142_abnormal_muscle_tone1.66771356
36MP0002138_abnormal_hepatobiliary_system1.60840764
37MP0002877_abnormal_melanocyte_morpholog1.60389098
38MP0008058_abnormal_DNA_repair1.58750654
39MP0003385_abnormal_body_wall1.57641687
40MP0003279_aneurysm1.56982885
41MP0010307_abnormal_tumor_latency1.55839348
42MP0003937_abnormal_limbs/digits/tail_de1.46452203
43MP0003077_abnormal_cell_cycle1.44789166
44MP0001293_anophthalmia1.44284334
45MP0004134_abnormal_chest_morphology1.43487885
46MP0001270_distended_abdomen1.41004272
47MP0001968_abnormal_touch/_nociception1.37889224
48MP0002736_abnormal_nociception_after1.37613459
49MP0008872_abnormal_physiological_respon1.36875435
50MP0005410_abnormal_fertilization1.36331599
51MP0001545_abnormal_hematopoietic_system1.36318978
52MP0005397_hematopoietic_system_phenotyp1.36318978
53MP0004145_abnormal_muscle_electrophysio1.32822634
54MP0002109_abnormal_limb_morphology1.32113730
55MP0008789_abnormal_olfactory_epithelium1.31416007
56MP0003111_abnormal_nucleus_morphology1.31292032
57MP0005377_hearing/vestibular/ear_phenot1.27718859
58MP0003878_abnormal_ear_physiology1.27718859
59MP0002638_abnormal_pupillary_reflex1.27168838
60MP0003115_abnormal_respiratory_system1.24953054
61MP0000383_abnormal_hair_follicle1.19089538
62MP0002876_abnormal_thyroid_physiology1.17691117
63MP0003718_maternal_effect1.17439206
64MP0005195_abnormal_posterior_eye1.16339741
65MP0005171_absent_coat_pigmentation1.15835126
66MP0003880_abnormal_central_pattern1.15705038
67MP0002928_abnormal_bile_duct1.13771674
68MP0009703_decreased_birth_body1.13603043
69MP0003935_abnormal_craniofacial_develop1.13463749
70MP0009745_abnormal_behavioral_response1.12594451
71MP0004043_abnormal_pH_regulation1.12163485
72MP0000427_abnormal_hair_cycle1.11961698
73MP0000049_abnormal_middle_ear1.11377015
74MP0003011_delayed_dark_adaptation1.10872724
75MP0005084_abnormal_gallbladder_morpholo1.10756488
76MP0009046_muscle_twitch1.08644072
77MP0002272_abnormal_nervous_system1.08606581
78MP0005508_abnormal_skeleton_morphology1.08421077
79MP0002932_abnormal_joint_morphology1.07895571
80MP0003828_pulmonary_edema1.07780425
81MP0002210_abnormal_sex_determination1.05195801
82MP0003755_abnormal_palate_morphology1.04575070
83MP0002751_abnormal_autonomic_nervous1.03591472
84MP0005275_abnormal_skin_tensile1.02845861
85MP0001919_abnormal_reproductive_system1.02000038
86MP0002115_abnormal_skeleton_extremities1.01879272
87MP0001929_abnormal_gametogenesis1.01419423
88MP0001986_abnormal_taste_sensitivity1.00758481
89MP0002116_abnormal_craniofacial_bone1.00662586
90MP0000026_abnormal_inner_ear0.99543492
91MP0001486_abnormal_startle_reflex0.98888839
92MP0003119_abnormal_digestive_system0.98670806
93MP0005379_endocrine/exocrine_gland_phen0.98628867
94MP0002234_abnormal_pharynx_morphology0.98545755
95MP0002108_abnormal_muscle_morphology0.98533956
96MP0000778_abnormal_nervous_system0.98291295
97MP0002160_abnormal_reproductive_system0.95037700
98MP0005409_darkened_coat_color0.94931587
99MP0001119_abnormal_female_reproductive0.93961852
100MP0006276_abnormal_autonomic_nervous0.93671555
101MP0002282_abnormal_trachea_morphology0.93099979
102MP0000432_abnormal_head_morphology0.92653662
103MP0005391_vision/eye_phenotype0.92061217
104MP0008775_abnormal_heart_ventricle0.91857412
105MP0005623_abnormal_meninges_morphology0.91310097
106MP0009379_abnormal_foot_pigmentation0.90920937
107MP0001958_emphysema0.90861889
108MP0000767_abnormal_smooth_muscle0.90847768
109MP0004133_heterotaxia0.90443151
110MP0004147_increased_porphyrin_level0.89991170
111MP0002163_abnormal_gland_morphology0.89767598
112MP0002177_abnormal_outer_ear0.89534512
113MP0002114_abnormal_axial_skeleton0.89190547
114MP0010030_abnormal_orbit_morphology0.89137969
115MP0000653_abnormal_sex_gland0.88957460
116MP0008932_abnormal_embryonic_tissue0.88762196
117MP0004272_abnormal_basement_membrane0.88073329
118MP0009697_abnormal_copulation0.86747180
119MP0004197_abnormal_fetal_growth/weight/0.86667467
120MP0001286_abnormal_eye_development0.86205945
121MP0003567_abnormal_fetal_cardiomyocyte0.85893089
122MP0000534_abnormal_ureter_morphology0.85396538
123MP0000428_abnormal_craniofacial_morphol0.84544433
124MP0000462_abnormal_digestive_system0.84405036
125MP0001963_abnormal_hearing_physiology0.83723802
126MP0002113_abnormal_skeleton_development0.83635871
127MP0002925_abnormal_cardiovascular_devel0.83579879
128MP0001145_abnormal_male_reproductive0.82187965
129MP0003786_premature_aging0.81980132
130MP0002166_altered_tumor_susceptibility0.81405149
131MP0003045_fibrosis0.80776712
132MP0003698_abnormal_male_reproductive0.80710856
133MP0005257_abnormal_intraocular_pressure0.80663486
134MP0000566_synostosis0.80649866
135MP0002102_abnormal_ear_morphology0.80229784
136MP0002752_abnormal_somatic_nervous0.79489107
137MP0001984_abnormal_olfaction0.79481655
138MP0001324_abnormal_eye_pigmentation0.79268403
139MP0000230_abnormal_systemic_arterial0.78531369
140MP0000631_abnormal_neuroendocrine_gland0.78306309
141MP0005646_abnormal_pituitary_gland0.77763899
142MP0000163_abnormal_cartilage_morphology0.77070336
143MP0002095_abnormal_skin_pigmentation0.76824326
144MP0009053_abnormal_anal_canal0.76669461
145MP0006292_abnormal_olfactory_placode0.76543043
146MP0003315_abnormal_perineum_morphology0.75573409
147MP0005253_abnormal_eye_physiology0.74568905
148MP0005389_reproductive_system_phenotype0.73685412
149MP0005647_abnormal_sex_gland0.73186109
150MP0000372_irregular_coat_pigmentation0.72880105
151MP0002249_abnormal_larynx_morphology0.72038175
152MP0001970_abnormal_pain_threshold0.71709313
153MP0004130_abnormal_muscle_cell0.71631684
154MP0004215_abnormal_myocardial_fiber0.71557302
155MP0001175_abnormal_lung_morphology0.71484511
156MP0002006_tumorigenesis0.71439117
157MP0008875_abnormal_xenobiotic_pharmacok0.71231590
158MP0000015_abnormal_ear_pigmentation0.70338840
159MP0001299_abnormal_eye_distance/0.70282974
160MP0006072_abnormal_retinal_apoptosis0.68830069

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.40245211
2Congenital stationary night blindness (HP:0007642)3.89365839
3Chromsome breakage (HP:0040012)3.43819967
4Asymmetry of the thorax (HP:0001555)3.35262551
5True hermaphroditism (HP:0010459)3.30498473
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.20622489
7Short 4th metacarpal (HP:0010044)3.20622489
8Pendular nystagmus (HP:0012043)3.19261118
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.14781702
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.10319235
11Embryonal renal neoplasm (HP:0011794)2.94028370
12Nephroblastoma (Wilms tumor) (HP:0002667)2.91197373
13Abnormality of the renal cortex (HP:0011035)2.81654182
14Abnormal rod and cone electroretinograms (HP:0008323)2.78643723
15Pancreatic fibrosis (HP:0100732)2.76532653
16Abolished electroretinogram (ERG) (HP:0000550)2.76517027
17Abnormality of chromosome stability (HP:0003220)2.74529032
18Abnormality of the fingertips (HP:0001211)2.71192593
19Deep philtrum (HP:0002002)2.70747313
20Tubulointerstitial nephritis (HP:0001970)2.70431603
21Acute lymphatic leukemia (HP:0006721)2.69878410
22Increased corneal curvature (HP:0100692)2.64248077
23Keratoconus (HP:0000563)2.64248077
24Chronic hepatic failure (HP:0100626)2.59295197
25Ectopic kidney (HP:0000086)2.58033836
26Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.57520550
27Septo-optic dysplasia (HP:0100842)2.56920773
28Decreased central vision (HP:0007663)2.56636523
29Abnormality of the proximal phalanges of the hand (HP:0009834)2.54352340
30Macroorchidism (HP:0000053)2.50128029
31Nephronophthisis (HP:0000090)2.48150389
32Abnormality of the phalanges of the 5th finger (HP:0004213)2.48022723
33Genetic anticipation (HP:0003743)2.48006422
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.47012983
35Absent/shortened dynein arms (HP:0200106)2.47012983
36Abnormality of the phalanges of the 2nd finger (HP:0009541)2.45343937
37Abnormal respiratory motile cilium physiology (HP:0012261)2.44257585
38Tubular atrophy (HP:0000092)2.40351152
39Anencephaly (HP:0002323)2.38052517
40Increased nuchal translucency (HP:0010880)2.36775587
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35890557
42Germ cell neoplasia (HP:0100728)2.35261583
43Abnormality of the renal medulla (HP:0100957)2.34614968
44Chorioretinal atrophy (HP:0000533)2.31835054
45Medial flaring of the eyebrow (HP:0010747)2.31084162
46Male pseudohermaphroditism (HP:0000037)2.30587062
47Sclerocornea (HP:0000647)2.30269654
48Meckel diverticulum (HP:0002245)2.29768030
49Optic nerve hypoplasia (HP:0000609)2.26785230
50Acute myeloid leukemia (HP:0004808)2.26021703
51Hyperventilation (HP:0002883)2.26006857
52Hyperglycinemia (HP:0002154)2.24666133
53Midline defect of the nose (HP:0004122)2.21016835
54Abnormality of the 4th metacarpal (HP:0010012)2.19239482
55Cystic liver disease (HP:0006706)2.18487858
56Bile duct proliferation (HP:0001408)2.16709516
57Abnormal biliary tract physiology (HP:0012439)2.16709516
58Abnormality of the middle phalanges of the toes (HP:0010183)2.16432143
59Abnormality of the ileum (HP:0001549)2.15413738
60Attenuation of retinal blood vessels (HP:0007843)2.14795253
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.09510751
62Gaze-evoked nystagmus (HP:0000640)2.08172221
63Truncal obesity (HP:0001956)2.08094328
64Long eyelashes (HP:0000527)2.07738426
65Abnormality of the nasal septum (HP:0000419)2.06763102
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.06261137
67Abnormal hair whorl (HP:0010721)2.06093763
68Enlarged penis (HP:0000040)2.05910893
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05780319
70Protrusio acetabuli (HP:0003179)2.05295709
71Oligodactyly (hands) (HP:0001180)2.02096763
72Dislocated radial head (HP:0003083)2.01422570
73Abnormality of the preputium (HP:0100587)2.01190289
74Natal tooth (HP:0000695)2.00986098
75Severe visual impairment (HP:0001141)1.99732964
76Type II lissencephaly (HP:0007260)1.98760118
77Papillary thyroid carcinoma (HP:0002895)1.98623523
78Fibular hypoplasia (HP:0003038)1.98554467
79Intestinal atresia (HP:0011100)1.97730669
80Abnormality of dentin (HP:0010299)1.95976222
81Stomach cancer (HP:0012126)1.95561016
82Short hallux (HP:0010109)1.95096825
83Bony spicule pigmentary retinopathy (HP:0007737)1.94476036
84Abnormal ciliary motility (HP:0012262)1.94157653
85Furrowed tongue (HP:0000221)1.93325115
86Abnormality of the renal collecting system (HP:0004742)1.91759229
87Rhinitis (HP:0012384)1.91671948
88Small hand (HP:0200055)1.91497636
89Progressive cerebellar ataxia (HP:0002073)1.91349851
90Triphalangeal thumb (HP:0001199)1.90913759
91Abnormality of alanine metabolism (HP:0010916)1.90676875
92Hyperalaninemia (HP:0003348)1.90676875
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90676875
94Abnormality of the carotid arteries (HP:0005344)1.90192036
95Thyroiditis (HP:0100646)1.89456387
96Renal cortical cysts (HP:0000803)1.89176586
97Embryonal neoplasm (HP:0002898)1.89166910
98Absent thumb (HP:0009777)1.88710324
99Myelodysplasia (HP:0002863)1.87893847
100Molar tooth sign on MRI (HP:0002419)1.87752371
101Abnormality of midbrain morphology (HP:0002418)1.87752371
102Abnormality of the radial head (HP:0003995)1.87630130
103Clubbing of toes (HP:0100760)1.87024550
104Colon cancer (HP:0003003)1.84836324
105White forelock (HP:0002211)1.84678717
106Aplasia/Hypoplasia of the hallux (HP:0008362)1.84308248
107Pancreatic cysts (HP:0001737)1.84032412
108Congenital, generalized hypertrichosis (HP:0004540)1.83798779
109Aplasia/Hypoplasia of the spleen (HP:0010451)1.83077010
110Synophrys (HP:0000664)1.83037232
111Hypoplasia of the uterus (HP:0000013)1.82999083
112Spondylolisthesis (HP:0003302)1.81394788
113Shallow orbits (HP:0000586)1.81248156
114Diastasis recti (HP:0001540)1.80119426
115Abnormal respiratory epithelium morphology (HP:0012253)1.79941145
116Abnormal respiratory motile cilium morphology (HP:0005938)1.79941145
117Short middle phalanx of the 5th finger (HP:0004220)1.79914871
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.79543904
119Astigmatism (HP:0000483)1.79407297
120Obsessive-compulsive behavior (HP:0000722)1.79361717
121Spinal cord lesions (HP:0100561)1.78526056
122Syringomyelia (HP:0003396)1.78526056
123Gastrointestinal atresia (HP:0002589)1.78185269
124Mesomelia (HP:0003027)1.77680330
125Oligohydramnios (HP:0001562)1.77391959
126Renal duplication (HP:0000075)1.77181675
127Medulloblastoma (HP:0002885)1.77059745
128Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76104842
129Abnormality of the duodenum (HP:0002246)1.76002032
130Postaxial hand polydactyly (HP:0001162)1.75833171
131Esophageal atresia (HP:0002032)1.75581503
132Aortic aneurysm (HP:0004942)1.74982759
133Aplasia/Hypoplasia of the patella (HP:0006498)1.74770107
134Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74738138
135Patchy hypopigmentation of hair (HP:0011365)1.74635742
136Hypoplastic iliac wings (HP:0002866)1.74480069
137Occipital encephalocele (HP:0002085)1.74233949
138Broad phalanges of the hand (HP:0009768)1.73691632
139Asplenia (HP:0001746)1.73691567
140Preaxial hand polydactyly (HP:0001177)1.73187028
141Abnormality of DNA repair (HP:0003254)1.72126167
142Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71808687
1433-Methylglutaconic aciduria (HP:0003535)1.71580156
144Broad finger (HP:0001500)1.70141990
145Broad long bones (HP:0005622)1.69643108
146Absent frontal sinuses (HP:0002688)1.68545563
147Sloping forehead (HP:0000340)1.68531714
148Broad phalanx (HP:0006009)1.68008626
149Highly arched eyebrow (HP:0002553)1.67878257
150Broad palm (HP:0001169)1.67467027
151Abnormality of the parietal bone (HP:0002696)1.66897528
152Small intestinal stenosis (HP:0012848)1.66511223
153Duodenal stenosis (HP:0100867)1.66511223
154Broad thumb (HP:0011304)1.65746623
155Tracheomalacia (HP:0002779)1.64568800
156Bowel diverticulosis (HP:0005222)1.63640283
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63505200
158Postaxial foot polydactyly (HP:0001830)1.63470890
159Hepatoblastoma (HP:0002884)1.63457941
160Hypoventilation (HP:0002791)1.62670837
161Renal dysplasia (HP:0000110)1.62542903
162Convex nasal ridge (HP:0000444)1.62542689
163Microglossia (HP:0000171)1.61575556
164Congenital hepatic fibrosis (HP:0002612)1.61520388
165Aortic dissection (HP:0002647)1.60282009
166Thin bony cortex (HP:0002753)1.59768365
167Overgrowth (HP:0001548)1.58380554
168Narrow palate (HP:0000189)1.57401788
169Supernumerary spleens (HP:0009799)1.57088423
170Breast carcinoma (HP:0003002)1.57050896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.19012012
2SRPK13.02977520
3NUAK12.95286825
4MKNK22.88314025
5LATS12.88216615
6STK32.46180256
7STK42.38353995
8MKNK12.31528628
9ADRBK22.29771679
10STK382.22748029
11WNK32.14222784
12GRK12.12231232
13PKN22.08444264
14MAP4K22.08000182
15TRIB32.05745042
16NEK22.03342173
17MAP2K71.98701052
18ACVR1B1.94247001
19NEK91.87829683
20PLK41.74653537
21NEK11.74604249
22CDK81.74132978
23CHEK21.70285778
24PNCK1.68108071
25ATR1.64386214
26TNIK1.61296109
27MAP3K61.60515482
28ERBB31.60424356
29CDK61.59427591
30TLK11.58126866
31FRK1.57429242
32INSRR1.52877330
33PRKD31.50398182
34CAMK1G1.49754668
35PASK1.43455723
36PINK11.42965689
37CAMK1D1.39508045
38IRAK11.33980181
39TIE11.33571219
40ATM1.29685624
41MAP3K131.29144659
42WNK41.28577138
43CASK1.23121061
44SGK21.23114206
45TGFBR11.22895104
46BRSK21.22407020
47STK391.19700874
48TAF11.15343323
49DMPK1.15182573
50CLK11.13286540
51CDK91.12907912
52CDK41.11465193
53ZAK1.08783022
54AURKB1.06619567
55TEC1.01572618
56WEE10.97787693
57AKT30.96393895
58HIPK20.95341118
59DYRK20.93390312
60STK38L0.91957267
61NEK60.91693514
62STK240.90945396
63OXSR10.89377924
64TTK0.88704954
65GRK70.87814599
66ADRBK10.86462226
67BMPR1B0.86325515
68FLT30.85071946
69NLK0.83302333
70PRKD20.81930430
71TRPM70.79871108
72PLK10.79250220
73TXK0.78452070
74CHUK0.76737393
75VRK10.75604166
76SGK30.75510657
77VRK20.75073157
78CDK70.71736543
79PRKCE0.71596916
80CDK120.71519178
81CDK30.70796445
82STK160.70634665
83IRAK20.69561230
84CHEK10.69324595
85FGFR20.68693315
86TAOK30.68690479
87MAPK130.67779425
88PLK30.67474175
89GRK50.65571273
90PDGFRA0.65437001
91PRKCG0.64628237
92PIK3CA0.64622509
93MAP3K40.64360533
94PTK60.64202264
95RET0.62764834
96WNK10.60785276
97PRKCH0.60187938
98CDK10.58587194
99ILK0.58300931
100PRKDC0.58104021
101EIF2AK20.57734730
102PTK2B0.57578369
103EIF2AK30.57046832
104PIK3CG0.56444185
105MAPK150.55747255
106KIT0.55378941
107MAPKAPK50.55225036
108PKN10.54618723
109CCNB10.54559786
110MAPKAPK30.53819984
111NTRK30.53744440
112PRKAA20.52567224
113CDC42BPA0.50145656
114BRD40.48336200
115SIK30.48072756
116CDK20.48013936
117PDGFRB0.45894408
118RPS6KA40.45781468
119MAPK140.45719434
120BCKDK0.45107292
121TGFBR20.44787895
122CAMKK10.43470913
123PAK20.43372907
124MTOR0.43290007
125PLK20.42509615
126IKBKB0.42048600
127MUSK0.41667205
128SIK10.39957738
129DYRK30.39196347
130MST40.37809923
131PRKACA0.37706680
132CSNK1G10.37127634
133RPS6KA50.37126545
134MELK0.36963277
135ERBB20.36865012
136RPS6KB10.36809329
137CAMKK20.36540786
138AKT10.36244391
139MAPK100.36163268
140STK110.36048151
141MAPK10.35099727
142PRKG10.33924545
143PIM10.33766718
144CAMK2A0.33548209
145NTRK20.33391685
146PRKCQ0.33204150
147EPHB20.32480191
148CSNK1G20.32461735
149AURKA0.32073837
150CSNK1D0.31963153
151CAMK10.31785158
152CSNK1A10.28666854
153BUB10.27989600
154CSNK2A10.27573053

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.61856057
2Fanconi anemia pathway_Homo sapiens_hsa034602.53204675
3DNA replication_Homo sapiens_hsa030302.45434552
4Non-homologous end-joining_Homo sapiens_hsa034502.27578870
5Mismatch repair_Homo sapiens_hsa034302.23614490
6Homologous recombination_Homo sapiens_hsa034402.21867367
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08249628
8Nitrogen metabolism_Homo sapiens_hsa009102.04566869
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01000085
10Linoleic acid metabolism_Homo sapiens_hsa005911.93851861
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92870434
12Phototransduction_Homo sapiens_hsa047441.84422758
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74375902
14Nicotine addiction_Homo sapiens_hsa050331.73942249
15Base excision repair_Homo sapiens_hsa034101.72366057
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.64626057
17One carbon pool by folate_Homo sapiens_hsa006701.63494139
18Chemical carcinogenesis_Homo sapiens_hsa052041.61411950
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.61107233
20RNA polymerase_Homo sapiens_hsa030201.57043547
21Retinol metabolism_Homo sapiens_hsa008301.55798614
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.54361532
23Tryptophan metabolism_Homo sapiens_hsa003801.50260436
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.47392856
25Butanoate metabolism_Homo sapiens_hsa006501.45686984
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43889126
27Nucleotide excision repair_Homo sapiens_hsa034201.43735989
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40528489
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.40197262
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40174740
31RNA degradation_Homo sapiens_hsa030181.37300749
32Basal transcription factors_Homo sapiens_hsa030221.33515939
33Oxidative phosphorylation_Homo sapiens_hsa001901.32474617
34Caffeine metabolism_Homo sapiens_hsa002321.31672778
35Ether lipid metabolism_Homo sapiens_hsa005651.29363202
36Prostate cancer_Homo sapiens_hsa052151.28596749
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.27862787
38MicroRNAs in cancer_Homo sapiens_hsa052061.27105954
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26944426
40TGF-beta signaling pathway_Homo sapiens_hsa043501.24382131
41Cocaine addiction_Homo sapiens_hsa050301.24248115
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21931170
43Ribosome_Homo sapiens_hsa030101.21825656
44Oocyte meiosis_Homo sapiens_hsa041141.20612839
45Small cell lung cancer_Homo sapiens_hsa052221.17421767
46ECM-receptor interaction_Homo sapiens_hsa045121.15353896
47Sulfur metabolism_Homo sapiens_hsa009201.12116287
48Propanoate metabolism_Homo sapiens_hsa006401.11103944
49Pancreatic cancer_Homo sapiens_hsa052121.10699789
50mRNA surveillance pathway_Homo sapiens_hsa030151.10398678
51Taste transduction_Homo sapiens_hsa047421.10070996
52N-Glycan biosynthesis_Homo sapiens_hsa005101.09389965
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08856516
54Colorectal cancer_Homo sapiens_hsa052101.08855304
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07982772
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06880319
57Platelet activation_Homo sapiens_hsa046111.05143957
58Chronic myeloid leukemia_Homo sapiens_hsa052201.04097708
59Selenocompound metabolism_Homo sapiens_hsa004501.03674649
60Focal adhesion_Homo sapiens_hsa045101.03643151
61Parkinsons disease_Homo sapiens_hsa050121.02084718
62Morphine addiction_Homo sapiens_hsa050321.01241988
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00539035
64Ovarian steroidogenesis_Homo sapiens_hsa049131.00319612
65p53 signaling pathway_Homo sapiens_hsa041150.99068792
66Glycerolipid metabolism_Homo sapiens_hsa005610.97893388
67Pyrimidine metabolism_Homo sapiens_hsa002400.96784501
68HTLV-I infection_Homo sapiens_hsa051660.96196779
69Prolactin signaling pathway_Homo sapiens_hsa049170.94031389
70Wnt signaling pathway_Homo sapiens_hsa043100.93489251
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92652205
72cAMP signaling pathway_Homo sapiens_hsa040240.91028043
73Thyroid cancer_Homo sapiens_hsa052160.90792784
74Melanoma_Homo sapiens_hsa052180.90360552
75Basal cell carcinoma_Homo sapiens_hsa052170.88442235
76Protein export_Homo sapiens_hsa030600.87764881
77Arachidonic acid metabolism_Homo sapiens_hsa005900.85264404
78Lysine degradation_Homo sapiens_hsa003100.85252271
79Huntingtons disease_Homo sapiens_hsa050160.85113816
80Pathways in cancer_Homo sapiens_hsa052000.84448354
81Hedgehog signaling pathway_Homo sapiens_hsa043400.84378227
82Alcoholism_Homo sapiens_hsa050340.84139088
83Serotonergic synapse_Homo sapiens_hsa047260.84030453
84Spliceosome_Homo sapiens_hsa030400.83913079
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83288472
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82878102
87Hepatitis B_Homo sapiens_hsa051610.82717211
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82693923
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.82526801
90Cardiac muscle contraction_Homo sapiens_hsa042600.81911732
91Herpes simplex infection_Homo sapiens_hsa051680.80136101
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79862123
93RNA transport_Homo sapiens_hsa030130.79544195
94Glioma_Homo sapiens_hsa052140.78237636
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76589435
96Non-small cell lung cancer_Homo sapiens_hsa052230.76148670
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75999341
98Peroxisome_Homo sapiens_hsa041460.74943924
99Primary immunodeficiency_Homo sapiens_hsa053400.74905127
100Viral carcinogenesis_Homo sapiens_hsa052030.74711338
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73678335
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.73495460
103FoxO signaling pathway_Homo sapiens_hsa040680.73422830
104Proteoglycans in cancer_Homo sapiens_hsa052050.73043607
105Endometrial cancer_Homo sapiens_hsa052130.72786417
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70252840
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69504985
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68716626
109Dilated cardiomyopathy_Homo sapiens_hsa054140.68716228
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68566606
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67597281
112Melanogenesis_Homo sapiens_hsa049160.67097628
113Renin secretion_Homo sapiens_hsa049240.66560204
114Insulin secretion_Homo sapiens_hsa049110.65912943
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65869141
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65700049
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65192998
118Type II diabetes mellitus_Homo sapiens_hsa049300.64485442
119Histidine metabolism_Homo sapiens_hsa003400.64137999
120Cholinergic synapse_Homo sapiens_hsa047250.63870536
121Alzheimers disease_Homo sapiens_hsa050100.63725587
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63531252
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63195879
124Regulation of autophagy_Homo sapiens_hsa041400.63168966
125Circadian entrainment_Homo sapiens_hsa047130.63127011
126Toxoplasmosis_Homo sapiens_hsa051450.62657719
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.61905815
128Amphetamine addiction_Homo sapiens_hsa050310.61347036
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61175172
130Olfactory transduction_Homo sapiens_hsa047400.60848997
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60713171
132Thyroid hormone synthesis_Homo sapiens_hsa049180.60414216
133Adherens junction_Homo sapiens_hsa045200.59686102
134beta-Alanine metabolism_Homo sapiens_hsa004100.59649612
135Fatty acid degradation_Homo sapiens_hsa000710.59637460
136Systemic lupus erythematosus_Homo sapiens_hsa053220.59303755
137Glutamatergic synapse_Homo sapiens_hsa047240.59264642
138B cell receptor signaling pathway_Homo sapiens_hsa046620.59258311
139Estrogen signaling pathway_Homo sapiens_hsa049150.58690538
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58453704
141Sulfur relay system_Homo sapiens_hsa041220.58412254
142Hippo signaling pathway_Homo sapiens_hsa043900.57493512
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.57456388
144MAPK signaling pathway_Homo sapiens_hsa040100.57012100
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56775249
146Viral myocarditis_Homo sapiens_hsa054160.56474260
147Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56446173
148Calcium signaling pathway_Homo sapiens_hsa040200.55828405
149Dopaminergic synapse_Homo sapiens_hsa047280.55666780
150Purine metabolism_Homo sapiens_hsa002300.55500961
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54365649
152Protein digestion and absorption_Homo sapiens_hsa049740.54363888
153NF-kappa B signaling pathway_Homo sapiens_hsa040640.54323180
154TNF signaling pathway_Homo sapiens_hsa046680.54190189
155Dorso-ventral axis formation_Homo sapiens_hsa043200.54065012
156Glucagon signaling pathway_Homo sapiens_hsa049220.53465727
157Rap1 signaling pathway_Homo sapiens_hsa040150.53117735
158Maturity onset diabetes of the young_Homo sapiens_hsa049500.52660356
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52414206
160Circadian rhythm_Homo sapiens_hsa047100.52347491
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51314449
162Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50454864
163Cysteine and methionine metabolism_Homo sapiens_hsa002700.49258569
164ABC transporters_Homo sapiens_hsa020100.49199740
165Metabolic pathways_Homo sapiens_hsa011000.45371600
166Fat digestion and absorption_Homo sapiens_hsa049750.45118137
167Asthma_Homo sapiens_hsa053100.43402588
168GABAergic synapse_Homo sapiens_hsa047270.40773581

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