CNTN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. The encoded glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein plays a role in the proliferation, migration, and axon guidance of neurons of the developing cerebellum. A mutation in this gene may be associated with adult myoclonic epilepsy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* axon ensheathment in central nervous system (GO:0032291)7.29160999
2* central nervous system myelination (GO:0022010)7.29160999
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.11541714
4pyrimidine nucleobase catabolic process (GO:0006208)4.68542965
5layer formation in cerebral cortex (GO:0021819)4.57652109
6neuron cell-cell adhesion (GO:0007158)4.54377702
7synaptic vesicle maturation (GO:0016188)4.43093598
8response to pheromone (GO:0019236)4.40312890
9neuronal action potential propagation (GO:0019227)4.37951158
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35151450
11postsynaptic membrane organization (GO:0001941)4.34728882
12cerebellar Purkinje cell differentiation (GO:0021702)4.20493440
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.14997683
14sodium ion export (GO:0071436)4.08310978
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98265147
16* neuron recognition (GO:0008038)3.97678369
17* myelination (GO:0042552)3.96874661
18* ensheathment of neurons (GO:0007272)3.95134169
19* axon ensheathment (GO:0008366)3.95134169
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93640452
21locomotory exploration behavior (GO:0035641)3.90973670
22cerebellar granule cell differentiation (GO:0021707)3.90314877
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.89763678
24establishment of mitochondrion localization (GO:0051654)3.86027587
25* axonal fasciculation (GO:0007413)3.84623365
26long-chain fatty acid biosynthetic process (GO:0042759)3.83879668
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.83036552
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.79546954
29mitochondrion transport along microtubule (GO:0047497)3.79546954
30* adult walking behavior (GO:0007628)3.78033000
31neurotransmitter-gated ion channel clustering (GO:0072578)3.76911165
32nucleobase catabolic process (GO:0046113)3.76440922
33vocalization behavior (GO:0071625)3.76300448
34cell migration in hindbrain (GO:0021535)3.72268544
35potassium ion import (GO:0010107)3.72075763
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.71953473
37synaptic vesicle exocytosis (GO:0016079)3.71903834
38L-amino acid import (GO:0043092)3.70592166
39negative regulation of neurotransmitter transport (GO:0051589)3.68488766
40negative regulation of protein localization to cell surface (GO:2000009)3.66239853
41gamma-aminobutyric acid transport (GO:0015812)3.65217123
42positive regulation of dendritic spine morphogenesis (GO:0061003)3.64189351
43glycine transport (GO:0015816)3.63668018
44positive regulation of synapse maturation (GO:0090129)3.63101786
45dendritic spine morphogenesis (GO:0060997)3.61017811
46mating behavior (GO:0007617)3.59060167
47protein localization to synapse (GO:0035418)3.54301524
48regulation of synaptic vesicle exocytosis (GO:2000300)3.50347687
49fatty acid elongation (GO:0030497)3.49875828
50transmission of nerve impulse (GO:0019226)3.49848149
51neuromuscular synaptic transmission (GO:0007274)3.48906430
52dendrite morphogenesis (GO:0048813)3.46296545
53regulation of neurotransmitter secretion (GO:0046928)3.44175804
54glutamate receptor signaling pathway (GO:0007215)3.42706705
55neurofilament cytoskeleton organization (GO:0060052)3.42690687
56glutamate secretion (GO:0014047)3.40597707
57negative regulation of neurotransmitter secretion (GO:0046929)3.36614329
58synapse assembly (GO:0007416)3.35996263
59synaptic transmission, glutamatergic (GO:0035249)3.35432649
60behavioral response to nicotine (GO:0035095)3.34766827
61* regulation of neuronal synaptic plasticity (GO:0048168)3.32210299
62cell differentiation in hindbrain (GO:0021533)3.30794575
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27296018
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26167914
65regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.25882581
66regulation of glutamate receptor signaling pathway (GO:1900449)3.25861218
67neuron-neuron synaptic transmission (GO:0007270)3.24729165
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.22504754
69regulation of neurotransmitter transport (GO:0051588)3.21343036
70presynaptic membrane assembly (GO:0097105)3.19614387
71myelin maintenance (GO:0043217)3.17932622
72negative regulation of axonogenesis (GO:0050771)3.17475835
73response to auditory stimulus (GO:0010996)3.16333651
74forebrain neuron differentiation (GO:0021879)3.14688636
75cellular potassium ion homeostasis (GO:0030007)3.12159012
76regulation of collateral sprouting (GO:0048670)3.11580603
77membrane repolarization (GO:0086009)3.11510889
78neurotransmitter secretion (GO:0007269)3.11508013
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11207473
80cerebral cortex radially oriented cell migration (GO:0021799)3.09131494
81axon extension (GO:0048675)3.08423604
82neuromuscular process controlling balance (GO:0050885)3.08308015
83positive regulation of membrane potential (GO:0045838)3.08060494
84regulation of synapse maturation (GO:0090128)3.07605575
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.07014499
86detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.06068003
87detection of temperature stimulus involved in sensory perception (GO:0050961)3.06068003
88central nervous system projection neuron axonogenesis (GO:0021952)3.05892663
89cerebellar Purkinje cell layer development (GO:0021680)3.04719928
90* presynaptic membrane organization (GO:0097090)3.02794464
91regulation of membrane repolarization (GO:0060306)3.02714685
92regulation of long-term neuronal synaptic plasticity (GO:0048169)3.01849078
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01394656
94synaptic vesicle endocytosis (GO:0048488)3.01129258
95regulation of dendritic spine morphogenesis (GO:0061001)3.00732239
96neuromuscular process controlling posture (GO:0050884)3.00212454
97potassium ion homeostasis (GO:0055075)2.99409630
98positive regulation of neurotransmitter transport (GO:0051590)2.97462228
99positive regulation of action potential (GO:0045760)2.97121614
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96972425
101exploration behavior (GO:0035640)2.94800964
102negative regulation of axon extension (GO:0030517)2.94395697
103long-term memory (GO:0007616)2.94392767
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.93623090
105retinal ganglion cell axon guidance (GO:0031290)2.92810923
106regulation of synaptic vesicle transport (GO:1902803)2.92670081
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90834082
108regulation of synapse structural plasticity (GO:0051823)2.90797668
109cellular response to electrical stimulus (GO:0071257)2.89897858
110auditory behavior (GO:0031223)2.89800593
111ovulation cycle (GO:0042698)2.88498298
112oligodendrocyte differentiation (GO:0048709)2.88289619
113regulation of neurotransmitter levels (GO:0001505)2.87632590
114mechanosensory behavior (GO:0007638)2.87341755
115neurotransmitter transport (GO:0006836)2.86884827
116membrane depolarization during action potential (GO:0086010)2.86087929
117* neuronal ion channel clustering (GO:0045161)2.85486529
118protein polyglutamylation (GO:0018095)2.85343829
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84230463
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83604222
121neurotransmitter uptake (GO:0001504)2.83051049
122positive regulation of dendritic spine development (GO:0060999)2.82566029
123membrane hyperpolarization (GO:0060081)2.82270794
124synapse organization (GO:0050808)2.82256430
125nerve growth factor signaling pathway (GO:0038180)2.81964471
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81088503
127positive regulation of synapse assembly (GO:0051965)2.80706882
128peptidyl-tyrosine autophosphorylation (GO:0038083)2.77653449
129establishment of nucleus localization (GO:0040023)2.76866955
130amino acid import (GO:0043090)2.76121832
131regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75654756
132detection of temperature stimulus (GO:0016048)2.73611365
133regulation of postsynaptic membrane potential (GO:0060078)2.73387791
134response to methylmercury (GO:0051597)2.73262081
135neuron remodeling (GO:0016322)2.73125287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84075180
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08493847
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08326056
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97965352
5GBX2_23144817_ChIP-Seq_PC3_Human2.97573948
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85633810
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85633810
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.81087401
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65242649
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63624050
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61973053
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.61259486
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52155544
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.50086067
15RNF2_27304074_Chip-Seq_ESCs_Mouse2.48406602
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46123731
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45704445
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.44599028
19REST_21632747_ChIP-Seq_MESCs_Mouse2.34206902
20DROSHA_22980978_ChIP-Seq_HELA_Human2.30743756
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23045945
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.07460926
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07169973
24AR_21572438_ChIP-Seq_LNCaP_Human2.05166821
25* REST_18959480_ChIP-ChIP_MESCs_Mouse1.92749319
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92359968
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84760243
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83015391
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80618508
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69472733
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68340746
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.67448380
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66221383
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66032849
35TAF15_26573619_Chip-Seq_HEK293_Human1.65064447
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63174525
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56424009
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.55428191
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.48934587
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48706187
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.39642082
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37310923
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36804624
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36300610
45IGF1R_20145208_ChIP-Seq_DFB_Human1.34995597
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.34724794
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33836554
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33513318
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28827480
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28047370
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26985568
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26796281
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24964683
54RNF2_27304074_Chip-Seq_NSC_Mouse1.24348681
55WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20235046
56P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19630112
57SMAD4_21799915_ChIP-Seq_A2780_Human1.19222780
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18754766
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17193808
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.17023746
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15859527
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15102247
63KDM2B_26808549_Chip-Seq_K562_Human1.14832663
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13884209
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12185891
66P300_19829295_ChIP-Seq_ESCs_Human1.11920291
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08471652
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07334188
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.04357049
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03693889
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00990275
72STAT3_23295773_ChIP-Seq_U87_Human0.99155238
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98581505
74CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97998219
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97621869
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97076931
77* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96831141
78NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96545297
79AR_19668381_ChIP-Seq_PC3_Human0.96480438
80TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95486088
81ER_23166858_ChIP-Seq_MCF-7_Human0.95414274
82AHR_22903824_ChIP-Seq_MCF-7_Human0.92357005
83YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91337027
84TCF4_23295773_ChIP-Seq_U87_Human0.91120126
85ZNF274_21170338_ChIP-Seq_K562_Hela0.90814138
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90542574
87* CTCF_27219007_Chip-Seq_Bcells_Human0.90468107
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89510189
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89510189
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88653601
91RXR_22108803_ChIP-Seq_LS180_Human0.88322545
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88261804
93* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87746810
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86620822
95RUNX2_22187159_ChIP-Seq_PCA_Human0.86338479
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.85957599
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.85590870
98* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85049001
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84697073
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.83976309
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.83597776
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83511423
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82587345
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82224503
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81945675
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.81040079
107* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80996443
108* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80791469
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80340024
110RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80208582
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79711176
112* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79288563
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.79241844
114STAT3_18555785_ChIP-Seq_MESCs_Mouse0.79084670
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78821632
116SOX9_26525672_Chip-Seq_HEART_Mouse0.78382773
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78334132
118* NANOG_18555785_Chip-Seq_ESCs_Mouse0.77054118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.02873798
2MP0003880_abnormal_central_pattern4.53487958
3MP0004270_analgesia3.85036866
4MP0003635_abnormal_synaptic_transmissio3.35945248
5MP0000778_abnormal_nervous_system3.09673174
6MP0009046_muscle_twitch3.07741698
7MP0000920_abnormal_myelination2.93408943
8MP0001486_abnormal_startle_reflex2.86582914
9* MP0002064_seizures2.79066448
10MP0002272_abnormal_nervous_system2.72852550
11* MP0009745_abnormal_behavioral_response2.64230536
12MP0002063_abnormal_learning/memory/cond2.63389615
13MP0003123_paternal_imprinting2.58554228
14MP0002734_abnormal_mechanical_nocicepti2.51147708
15MP0004885_abnormal_endolymph2.37765737
16MP0003329_amyloid_beta_deposits2.30596034
17MP0001968_abnormal_touch/_nociception2.27954173
18MP0008569_lethality_at_weaning2.27368222
19MP0002572_abnormal_emotion/affect_behav2.27029068
20MP0002733_abnormal_thermal_nociception2.25215802
21* MP0005423_abnormal_somatic_nervous2.13178641
22MP0001970_abnormal_pain_threshold2.08722556
23MP0004142_abnormal_muscle_tone2.02994787
24MP0001440_abnormal_grooming_behavior1.99213182
25* MP0000955_abnormal_spinal_cord1.97904337
26MP0002735_abnormal_chemical_nociception1.95350775
27MP0002067_abnormal_sensory_capabilities1.94216268
28* MP0002184_abnormal_innervation1.78411855
29MP0004811_abnormal_neuron_physiology1.78037429
30MP0006276_abnormal_autonomic_nervous1.77459249
31MP0003690_abnormal_glial_cell1.76954296
32MP0004742_abnormal_vestibular_system1.76713703
33MP0005645_abnormal_hypothalamus_physiol1.76264451
34MP0001529_abnormal_vocalization1.73453989
35MP0002736_abnormal_nociception_after1.71870912
36* MP0002882_abnormal_neuron_morphology1.71808548
37MP0001501_abnormal_sleep_pattern1.64539882
38MP0003632_abnormal_nervous_system1.61378061
39MP0002066_abnormal_motor_capabilities/c1.60684348
40MP0003634_abnormal_glial_cell1.59843583
41MP0006292_abnormal_olfactory_placode1.56073458
42MP0002822_catalepsy1.55787638
43MP0004924_abnormal_behavior1.53155938
44MP0005386_behavior/neurological_phenoty1.53155938
45MP0004145_abnormal_muscle_electrophysio1.51605168
46MP0005646_abnormal_pituitary_gland1.46820671
47MP0002557_abnormal_social/conspecific_i1.44188944
48MP0001905_abnormal_dopamine_level1.43444623
49MP0003631_nervous_system_phenotype1.42463891
50MP0003121_genomic_imprinting1.42362989
51MP0008877_abnormal_DNA_methylation1.41653956
52MP0002229_neurodegeneration1.40143437
53MP0004858_abnormal_nervous_system1.39579891
54MP0003633_abnormal_nervous_system1.37630714
55MP0008995_early_reproductive_senescence1.37211991
56MP0002653_abnormal_ependyma_morphology1.32114628
57MP0001984_abnormal_olfaction1.31123333
58MP0002152_abnormal_brain_morphology1.30787429
59MP0001502_abnormal_circadian_rhythm1.28414735
60MP0000631_abnormal_neuroendocrine_gland1.27137925
61MP0005171_absent_coat_pigmentation1.19865145
62MP0002638_abnormal_pupillary_reflex1.13385787
63MP0005409_darkened_coat_color1.12984613
64MP0001485_abnormal_pinna_reflex1.12875662
65* MP0002752_abnormal_somatic_nervous1.11925143
66MP0003183_abnormal_peptide_metabolism1.08801690
67MP0003137_abnormal_impulse_conducting1.07465074
68MP0003950_abnormal_plasma_membrane1.04927052
69MP0009780_abnormal_chondrocyte_physiolo1.03133919
70MP0003315_abnormal_perineum_morphology1.01690094
71MP0000604_amyloidosis1.01329302
72MP0001963_abnormal_hearing_physiology0.99376248
73MP0004134_abnormal_chest_morphology0.98012528
74MP0005623_abnormal_meninges_morphology0.97906971
75MP0003122_maternal_imprinting0.97663182
76MP0005410_abnormal_fertilization0.96666836
77MP0002909_abnormal_adrenal_gland0.95840591
78MP0001299_abnormal_eye_distance/0.95329394
79MP0004043_abnormal_pH_regulation0.95185539
80MP0006072_abnormal_retinal_apoptosis0.94910873
81MP0008004_abnormal_stomach_pH0.94219716
82MP0001177_atelectasis0.93492540
83MP0003861_abnormal_nervous_system0.88903265
84MP0005551_abnormal_eye_electrophysiolog0.88211708
85MP0002069_abnormal_eating/drinking_beha0.87387835
86MP0003136_yellow_coat_color0.86180684
87MP0000566_synostosis0.85573731
88MP0003938_abnormal_ear_development0.84731765
89MP0000462_abnormal_digestive_system0.83187482
90MP0003787_abnormal_imprinting0.82735581
91MP0008260_abnormal_autophagy0.81569383
92MP0008789_abnormal_olfactory_epithelium0.80337102
93MP0005253_abnormal_eye_physiology0.78969962
94MP0001346_abnormal_lacrimal_gland0.77921020
95MP0000569_abnormal_digit_pigmentation0.77014747
96MP0003890_abnormal_embryonic-extraembry0.76783422
97MP0002163_abnormal_gland_morphology0.76695603
98MP0005499_abnormal_olfactory_system0.76513587
99MP0005394_taste/olfaction_phenotype0.76513587
100MP0005195_abnormal_posterior_eye0.76470081
101MP0000026_abnormal_inner_ear0.75786077
102MP0003172_abnormal_lysosome_physiology0.73681121
103MP0005187_abnormal_penis_morphology0.73002489
104MP0002751_abnormal_autonomic_nervous0.72468534
105MP0001943_abnormal_respiration0.71395013
106MP0004085_abnormal_heartbeat0.70865002
107MP0001348_abnormal_lacrimal_gland0.70361087
108MP0003119_abnormal_digestive_system0.64878883
109MP0003879_abnormal_hair_cell0.64278876
110MP0010386_abnormal_urinary_bladder0.64192316
111MP0005535_abnormal_body_temperature0.64095339
112MP0000747_muscle_weakness0.63583735
113MP0010769_abnormal_survival0.62171433
114MP0001188_hyperpigmentation0.62169299
115MP0003283_abnormal_digestive_organ0.62033689
116MP0004130_abnormal_muscle_cell0.61787142
117MP0000751_myopathy0.61476140
118MP0000534_abnormal_ureter_morphology0.61088855
119MP0004133_heterotaxia0.60941033
120MP0010768_mortality/aging0.59758537
121MP0010770_preweaning_lethality0.59457915
122MP0002082_postnatal_lethality0.59457915
123MP0002081_perinatal_lethality0.56935865
124MP0001986_abnormal_taste_sensitivity0.56663734

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.74786319
2Focal motor seizures (HP:0011153)4.86398575
3Neurofibrillary tangles (HP:0002185)4.77020607
4Abnormality of the corticospinal tract (HP:0002492)4.71026203
5Supranuclear gaze palsy (HP:0000605)4.67271720
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.66254568
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.66254568
8Action tremor (HP:0002345)4.06673295
9Focal seizures (HP:0007359)4.02520950
10Peripheral hypomyelination (HP:0007182)3.83894324
11Ankle clonus (HP:0011448)3.80277260
12Abnormal eating behavior (HP:0100738)3.73293635
13Spastic gait (HP:0002064)3.72995333
14Cerebral inclusion bodies (HP:0100314)3.70828588
15Termporal pattern (HP:0011008)3.67770089
16Insidious onset (HP:0003587)3.67770089
17Onion bulb formation (HP:0003383)3.49969024
18Dysmetria (HP:0001310)3.47363444
19Scanning speech (HP:0002168)3.43158773
20Intention tremor (HP:0002080)3.41941240
21Progressive cerebellar ataxia (HP:0002073)3.34658065
22Hepatoblastoma (HP:0002884)3.33290491
23Abnormality of the lower motor neuron (HP:0002366)3.30665833
24Broad-based gait (HP:0002136)3.17909178
25Epileptic encephalopathy (HP:0200134)3.04749923
26Abnormal pancreas size (HP:0012094)2.99769464
27Megalencephaly (HP:0001355)2.94552072
28Urinary urgency (HP:0000012)2.90853453
29Visual hallucinations (HP:0002367)2.85910472
30Cerebral hypomyelination (HP:0006808)2.85389116
31Metaphyseal dysplasia (HP:0100255)2.82764506
32Hemiparesis (HP:0001269)2.68238770
33Truncal ataxia (HP:0002078)2.63914795
34Neoplasm of the adrenal cortex (HP:0100641)2.63016449
35Gaze-evoked nystagmus (HP:0000640)2.58320067
36Atonic seizures (HP:0010819)2.55518150
37Dysdiadochokinesis (HP:0002075)2.54949177
38Pendular nystagmus (HP:0012043)2.54102846
39Alacrima (HP:0000522)2.53274565
40Lower limb muscle weakness (HP:0007340)2.52304582
41Pheochromocytoma (HP:0002666)2.50611315
42Anxiety (HP:0000739)2.48475758
43Urinary bladder sphincter dysfunction (HP:0002839)2.46410249
44Prolonged QT interval (HP:0001657)2.44900562
45Insomnia (HP:0100785)2.43931082
46Impaired vibration sensation in the lower limbs (HP:0002166)2.41630281
47Febrile seizures (HP:0002373)2.39899800
48Hammertoe (HP:0001765)2.39390744
49Ventricular fibrillation (HP:0001663)2.38741020
50Craniofacial dystonia (HP:0012179)2.34302745
51Anomalous pulmonary venous return (HP:0010772)2.34037599
52Abnormal auditory evoked potentials (HP:0006958)2.33343903
53Neuroendocrine neoplasm (HP:0100634)2.32856410
54Dialeptic seizures (HP:0011146)2.31357352
55Neonatal hypoglycemia (HP:0001998)2.30906304
56Morphological abnormality of the pyramidal tract (HP:0002062)2.29803419
57Spastic tetraplegia (HP:0002510)2.29588587
58Generalized tonic-clonic seizures (HP:0002069)2.29155668
59Limb dystonia (HP:0002451)2.28502325
60Overriding aorta (HP:0002623)2.28335124
61Anteriorly placed anus (HP:0001545)2.27521830
62Sleep apnea (HP:0010535)2.22978549
63Clonus (HP:0002169)2.22469874
64Epileptiform EEG discharges (HP:0011182)2.22412643
65Agitation (HP:0000713)2.21605375
66Anosmia (HP:0000458)2.21568959
67Decreased motor nerve conduction velocity (HP:0003431)2.18988939
68Mutism (HP:0002300)2.18807341
69Segmental peripheral demyelination/remyelination (HP:0003481)2.18330577
70Gait imbalance (HP:0002141)2.17653936
71Absence seizures (HP:0002121)2.16345514
72Incomplete penetrance (HP:0003829)2.15867598
73Postural instability (HP:0002172)2.14002539
74Amyotrophic lateral sclerosis (HP:0007354)2.13562914
75Aplasia involving bones of the extremities (HP:0009825)2.12456375
76Aplasia involving bones of the upper limbs (HP:0009823)2.12456375
77Aplasia of the phalanges of the hand (HP:0009802)2.12456375
78Neuronal loss in central nervous system (HP:0002529)2.12136053
79Obstructive sleep apnea (HP:0002870)2.10117302
80Akinesia (HP:0002304)2.10025215
81Foot dorsiflexor weakness (HP:0009027)2.09737516
82Cortical dysplasia (HP:0002539)2.09368523
83Spastic tetraparesis (HP:0001285)2.08895201
84Depression (HP:0000716)2.08807581
85Hemiplegia (HP:0002301)2.07962032
86Impaired vibratory sensation (HP:0002495)2.06638470
87Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06466150
88Hypoplasia of the brainstem (HP:0002365)2.06466150
89Progressive inability to walk (HP:0002505)2.05984180
90Growth hormone deficiency (HP:0000824)2.05249431
91Excessive salivation (HP:0003781)2.04491479
92Drooling (HP:0002307)2.04491479
93Abnormality of binocular vision (HP:0011514)2.04444259
94Diplopia (HP:0000651)2.04444259
95Torticollis (HP:0000473)2.04229410
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04147254
97Status epilepticus (HP:0002133)2.02047930
98EEG with generalized epileptiform discharges (HP:0011198)2.01874072
99Poor eye contact (HP:0000817)2.01873291
100Hand muscle atrophy (HP:0009130)2.00805113
101Abnormality of the foot musculature (HP:0001436)2.00057049
102Hypoplasia of the corpus callosum (HP:0002079)1.96964163
103Abnormality of the pulmonary veins (HP:0011718)1.96525977
104Syncope (HP:0001279)1.94305522
105Hypsarrhythmia (HP:0002521)1.94125745
106Fetal akinesia sequence (HP:0001989)1.94123515
107Myotonia (HP:0002486)1.93265991
108Sensory axonal neuropathy (HP:0003390)1.93257086
109Slow saccadic eye movements (HP:0000514)1.91715249
110Distal sensory impairment (HP:0002936)1.90354492
111Decreased lacrimation (HP:0000633)1.90105737
112Buphthalmos (HP:0000557)1.89933988
113Hyperventilation (HP:0002883)1.89779696
114CNS hypomyelination (HP:0003429)1.89642213
115Bowel incontinence (HP:0002607)1.88907783
116Retinal dysplasia (HP:0007973)1.88078244
117Esotropia (HP:0000565)1.87920514
118Cutaneous finger syndactyly (HP:0010554)1.87149839
119Abnormality of saccadic eye movements (HP:0000570)1.86552588
120Polyphagia (HP:0002591)1.86357200
121Parakeratosis (HP:0001036)1.85400516
122Amblyopia (HP:0000646)1.84405596
123Specific learning disability (HP:0001328)1.82871550
124Spastic paraplegia (HP:0001258)1.82784489
125Paraplegia (HP:0010550)1.81210110
126Congenital malformation of the right heart (HP:0011723)1.80438304
127Double outlet right ventricle (HP:0001719)1.80438304
128Thickened helices (HP:0000391)1.80437645
129Split foot (HP:0001839)1.80340851
130Papilledema (HP:0001085)1.79499905
131Impaired social interactions (HP:0000735)1.79149107
132Abnormal social behavior (HP:0012433)1.79149107
133Focal dystonia (HP:0004373)1.77548896
134Absent speech (HP:0001344)1.77068316
135Ulnar claw (HP:0001178)1.76663425
136High anterior hairline (HP:0009890)1.76375508
137Failure to thrive in infancy (HP:0001531)1.75741631
138Genetic anticipation (HP:0003743)1.75712492
139Vaginal atresia (HP:0000148)1.75631181
140Impaired smooth pursuit (HP:0007772)1.75594364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA33.56104506
2MARK13.55511689
3STK393.09133397
4NTRK32.65824954
5OXSR12.64783220
6PAK62.54366236
7EPHA42.23333160
8MAP3K92.10084075
9PKN12.00599134
10UHMK12.00335887
11NTRK11.97690130
12CDK191.92103559
13MAP3K41.79879558
14LIMK11.76675005
15NTRK21.75572123
16PNCK1.73267620
17KSR21.71437390
18MINK11.64878005
19SGK2231.61404273
20SGK4941.61404273
21IRAK21.57088738
22CAMK1D1.56791434
23WNK11.54142308
24MAPKAPK51.53123071
25LATS21.52500579
26CASK1.50848854
27ROCK21.46172235
28CDK51.45696567
29CAMK2B1.44211202
30EPHB11.43370289
31BCR1.42246648
32TNIK1.40260488
33FGFR21.38889375
34SGK21.36176712
35PRPF4B1.36100574
36PHKG11.32987006
37PHKG21.32987006
38MAP2K71.29511512
39ZAK1.28717037
40MAPK131.27505428
41DAPK21.25294644
42TESK21.23929582
43CSNK1G21.19987349
44TYRO31.19912057
45CSNK1G31.17815075
46RIPK11.17351256
47MAP3K131.15528846
48MARK21.13654781
49CSNK1A1L1.13621044
50ERBB21.11937828
51KSR11.07604071
52DYRK1B1.05548093
53DYRK21.04930638
54PRKD31.04655384
55PAK31.02663484
56WNK41.01622096
57CAMK2D1.01416248
58SIK21.00632886
59ICK0.96161052
60CAMK2A0.93903123
61CDK150.93512564
62CAMK2G0.92236439
63CDK140.91438929
64ARAF0.90552207
65CDK180.90416883
66CAMKK10.88432827
67SGK30.88068204
68DYRK30.87690119
69NEK60.86404713
70STK110.83642597
71CDK11A0.80619249
72MAP2K40.79254228
73CSNK1G10.79143100
74CAMK1G0.77040657
75PRKCG0.72229299
76EPHB20.70325063
77BRD40.69871786
78PRKCH0.67524633
79WNK30.67191257
80MAP3K60.65721630
81ALK0.64987522
82DYRK1A0.61722033
83RPS6KA20.61567685
84PRKCZ0.61246434
85PRKD10.61170464
86DAPK30.61014053
87PRKCE0.59640693
88GRK50.59339209
89FYN0.57495791
90RIPK40.56152537
91FGR0.55136772
92MAPK100.54998128
93SGK10.54644850
94CAMKK20.54140090
95MET0.53464861
96FES0.53134033
97BRAF0.52233165
98IRAK10.51026080
99PRKG10.49725137
100MAP3K20.49654222
101CSNK1E0.48999503
102RET0.47954144
103PDPK10.47112052
104PLK20.46944205
105ROCK10.45898543
106CAMK10.43300978
107PINK10.41950924
108CDC42BPA0.41848776
109MAPK80.41631056
110RPS6KA30.41523899
111MAPK90.40369436
112MUSK0.39905894
113LMTK20.39793279
114STK380.39393254
115PRKACB0.38439746
116CAMK40.38038430
117PRKACA0.37696993
118MAP3K110.35223694
119PRKAA10.34765473
120CSNK1D0.32655971
121SRC0.31589810
122GSK3B0.31069338
123MAPK40.28447721
124PRKCA0.28035324
125PTK20.27715815

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.06037677
2GABAergic synapse_Homo sapiens_hsa047272.68917615
3Glutamatergic synapse_Homo sapiens_hsa047242.57424731
4Axon guidance_Homo sapiens_hsa043602.51010034
5Synaptic vesicle cycle_Homo sapiens_hsa047212.42972372
6Circadian entrainment_Homo sapiens_hsa047132.39721972
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34474659
8Morphine addiction_Homo sapiens_hsa050322.31599607
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21939486
10Nitrogen metabolism_Homo sapiens_hsa009102.00476897
11Salivary secretion_Homo sapiens_hsa049701.96229702
12Olfactory transduction_Homo sapiens_hsa047401.95029357
13Long-term potentiation_Homo sapiens_hsa047201.94288125
14Dopaminergic synapse_Homo sapiens_hsa047281.88948816
15Gastric acid secretion_Homo sapiens_hsa049711.81520139
16Long-term depression_Homo sapiens_hsa047301.80038527
17Amphetamine addiction_Homo sapiens_hsa050311.73619024
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71779838
19Cholinergic synapse_Homo sapiens_hsa047251.68818562
20Serotonergic synapse_Homo sapiens_hsa047261.68118320
21Cocaine addiction_Homo sapiens_hsa050301.66812384
22Taste transduction_Homo sapiens_hsa047421.65362904
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64764752
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62750375
25Insulin secretion_Homo sapiens_hsa049111.43730406
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43218364
27Steroid biosynthesis_Homo sapiens_hsa001001.41619828
28Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.41338871
29Fatty acid elongation_Homo sapiens_hsa000621.40484209
30Gap junction_Homo sapiens_hsa045401.35260136
31Renin secretion_Homo sapiens_hsa049241.30023628
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28611125
33Oxytocin signaling pathway_Homo sapiens_hsa049211.23120692
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22643299
35Cardiac muscle contraction_Homo sapiens_hsa042601.22490122
36Ether lipid metabolism_Homo sapiens_hsa005651.20910929
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16874967
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15397269
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14998226
40cAMP signaling pathway_Homo sapiens_hsa040241.13922918
41Calcium signaling pathway_Homo sapiens_hsa040201.13797066
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08198097
43GnRH signaling pathway_Homo sapiens_hsa049121.01063082
44ErbB signaling pathway_Homo sapiens_hsa040121.00634236
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99729856
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.99074781
47Type II diabetes mellitus_Homo sapiens_hsa049300.98676419
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97444779
49* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94213640
50Pancreatic secretion_Homo sapiens_hsa049720.94209555
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.92044052
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90129000
53Collecting duct acid secretion_Homo sapiens_hsa049660.89181773
54Dorso-ventral axis formation_Homo sapiens_hsa043200.88145805
55Estrogen signaling pathway_Homo sapiens_hsa049150.87956875
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.87922629
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87591181
58Renal cell carcinoma_Homo sapiens_hsa052110.86587440
59Melanogenesis_Homo sapiens_hsa049160.84119476
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75961559
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73869133
62Butanoate metabolism_Homo sapiens_hsa006500.72949377
63Choline metabolism in cancer_Homo sapiens_hsa052310.72666218
64MAPK signaling pathway_Homo sapiens_hsa040100.72326244
65Endocytosis_Homo sapiens_hsa041440.72127916
66Glioma_Homo sapiens_hsa052140.71566998
67Ras signaling pathway_Homo sapiens_hsa040140.69868153
68Inositol phosphate metabolism_Homo sapiens_hsa005620.68298271
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68134744
70Phototransduction_Homo sapiens_hsa047440.67599659
71Hedgehog signaling pathway_Homo sapiens_hsa043400.66298039
72Vibrio cholerae infection_Homo sapiens_hsa051100.66043159
73Dilated cardiomyopathy_Homo sapiens_hsa054140.64354541
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63937855
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63858453
76Bile secretion_Homo sapiens_hsa049760.62873092
77Parkinsons disease_Homo sapiens_hsa050120.61676439
78Oxidative phosphorylation_Homo sapiens_hsa001900.61215764
79Tight junction_Homo sapiens_hsa045300.61199217
80Hippo signaling pathway_Homo sapiens_hsa043900.59850751
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56761230
82Histidine metabolism_Homo sapiens_hsa003400.55765661
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.54550876
84Thyroid hormone synthesis_Homo sapiens_hsa049180.52757931
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52452361
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52072516
87Alzheimers disease_Homo sapiens_hsa050100.52058073
88Circadian rhythm_Homo sapiens_hsa047100.51741292
89Sphingolipid metabolism_Homo sapiens_hsa006000.51727393
90Alcoholism_Homo sapiens_hsa050340.51092377
91Fatty acid biosynthesis_Homo sapiens_hsa000610.50996455
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50078643
93Rap1 signaling pathway_Homo sapiens_hsa040150.47922162
94Oocyte meiosis_Homo sapiens_hsa041140.47533716
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47083583
96Ovarian steroidogenesis_Homo sapiens_hsa049130.46494938
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46480284
98Wnt signaling pathway_Homo sapiens_hsa043100.45114229
99Mineral absorption_Homo sapiens_hsa049780.43726434
100Vitamin B6 metabolism_Homo sapiens_hsa007500.42389294
101Endometrial cancer_Homo sapiens_hsa052130.41766986
102Prion diseases_Homo sapiens_hsa050200.41608501
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41399282
104Glucagon signaling pathway_Homo sapiens_hsa049220.40621708
105VEGF signaling pathway_Homo sapiens_hsa043700.37657882
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37262460
107Chemokine signaling pathway_Homo sapiens_hsa040620.36724050
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36419703
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.36234822
110Basal cell carcinoma_Homo sapiens_hsa052170.34768935
111Regulation of autophagy_Homo sapiens_hsa041400.34625658
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33409802
113Arginine and proline metabolism_Homo sapiens_hsa003300.31886007
114Colorectal cancer_Homo sapiens_hsa052100.30256687
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29367304
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28645689
117Huntingtons disease_Homo sapiens_hsa050160.24461468

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