CNTN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)6.22804126
2short-term memory (GO:0007614)5.65005373
3presynaptic membrane assembly (GO:0097105)4.91569742
4neuron cell-cell adhesion (GO:0007158)4.61523613
5ionotropic glutamate receptor signaling pathway (GO:0035235)4.49381880
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.47982731
7presynaptic membrane organization (GO:0097090)4.47066481
8protein localization to synapse (GO:0035418)4.41676006
9postsynaptic membrane organization (GO:0001941)4.38670502
10vocalization behavior (GO:0071625)4.28263891
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.25114705
12positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.22127228
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.18694512
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.16811791
15neuronal action potential propagation (GO:0019227)4.14833940
16glutamate receptor signaling pathway (GO:0007215)4.12313058
17cellular potassium ion homeostasis (GO:0030007)4.06634849
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05551987
19cerebellar Purkinje cell layer development (GO:0021680)4.05045784
20synaptic transmission, glutamatergic (GO:0035249)4.01569909
21regulation of glutamate receptor signaling pathway (GO:1900449)3.94465682
22cerebellar Purkinje cell differentiation (GO:0021702)3.92479082
23cell differentiation in hindbrain (GO:0021533)3.77033934
24neuron-neuron synaptic transmission (GO:0007270)3.70186714
25gamma-aminobutyric acid signaling pathway (GO:0007214)3.68613241
26response to pheromone (GO:0019236)3.68212440
27synaptic vesicle exocytosis (GO:0016079)3.65499374
28metanephric nephron tubule development (GO:0072234)3.63691195
29metanephric tubule development (GO:0072170)3.63691195
30C4-dicarboxylate transport (GO:0015740)3.61465398
31prepulse inhibition (GO:0060134)3.61381705
32retinal cone cell development (GO:0046549)3.60364403
33cellular sodium ion homeostasis (GO:0006883)3.58692918
34startle response (GO:0001964)3.58658621
35daunorubicin metabolic process (GO:0044597)3.58083705
36polyketide metabolic process (GO:0030638)3.58083705
37doxorubicin metabolic process (GO:0044598)3.58083705
38regulation of synaptic vesicle exocytosis (GO:2000300)3.57170314
39neurotransmitter-gated ion channel clustering (GO:0072578)3.56710451
40sodium ion export (GO:0071436)3.54505435
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51971667
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.43689498
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35721958
44regulation of synaptic vesicle transport (GO:1902803)3.34984086
45urinary tract smooth muscle contraction (GO:0014848)3.32069957
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.29471417
47positive regulation of muscle hypertrophy (GO:0014742)3.27728004
48positive regulation of cardiac muscle hypertrophy (GO:0010613)3.27728004
49innervation (GO:0060384)3.27540134
50cerebral cortex radially oriented cell migration (GO:0021799)3.25318958
51metanephric nephron epithelium development (GO:0072243)3.24626017
52righting reflex (GO:0060013)3.24122780
53glutamate secretion (GO:0014047)3.18217333
54regulation of postsynaptic membrane potential (GO:0060078)3.17625262
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17061904
56facial nerve structural organization (GO:0021612)3.17053358
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15561129
58positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.14095937
59positive regulation of neurotransmitter secretion (GO:0001956)3.11181367
60negative regulation of neurotransmitter transport (GO:0051589)3.10660913
61synaptic vesicle maturation (GO:0016188)3.06127898
62regulation of neurotransmitter secretion (GO:0046928)3.04741752
63positive regulation of membrane potential (GO:0045838)3.03966476
64regulation of neuronal synaptic plasticity (GO:0048168)3.03397906
65neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.01830207
66retina layer formation (GO:0010842)3.01250802
67mechanosensory behavior (GO:0007638)3.01066935
68cranial nerve structural organization (GO:0021604)3.00747961
69locomotory exploration behavior (GO:0035641)2.97805313
70central nervous system projection neuron axonogenesis (GO:0021952)2.97628040
71positive regulation of synapse assembly (GO:0051965)2.96790043
72positive regulation of dendritic spine morphogenesis (GO:0061003)2.96563934
73regulation of pigment cell differentiation (GO:0050932)2.96180712
74transmission of nerve impulse (GO:0019226)2.95950307
75neuron recognition (GO:0008038)2.95944709
76regulation of synaptic transmission, glutamatergic (GO:0051966)2.95121629
77metanephric epithelium development (GO:0072207)2.94024299
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93642437
79regulation of synapse assembly (GO:0051963)2.92635905
80auditory behavior (GO:0031223)2.91948816
81long-term memory (GO:0007616)2.91426608
82regulation of synaptic transmission, GABAergic (GO:0032228)2.90758575
83long-term synaptic potentiation (GO:0060291)2.89188010
84regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86355509
85regulation of neurotransmitter transport (GO:0051588)2.85931736
86positive regulation of neurotransmitter transport (GO:0051590)2.84867845
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84548051
88membrane depolarization during action potential (GO:0086010)2.84358540
89regulation of neuron projection regeneration (GO:0070570)2.83692338
90regulation of axon regeneration (GO:0048679)2.83692338
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83323308
92exploration behavior (GO:0035640)2.83188400
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82623248
94peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82417569
95positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.81610653
96neurofilament cytoskeleton organization (GO:0060052)2.79240724
97protein heterotetramerization (GO:0051290)2.78811433
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77454844
99learning (GO:0007612)2.77401139
100response to auditory stimulus (GO:0010996)2.76369651
101parturition (GO:0007567)2.75846906
102apical protein localization (GO:0045176)2.75606450
103dendrite development (GO:0016358)2.74825965
104behavioral response to cocaine (GO:0048148)2.73242425
105membrane depolarization (GO:0051899)2.72642424
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72522883
107multicellular organismal movement (GO:0050879)2.72195916
108musculoskeletal movement (GO:0050881)2.72195916
109central nervous system neuron axonogenesis (GO:0021955)2.72183939
110relaxation of smooth muscle (GO:0044557)2.69951537
111synapse assembly (GO:0007416)2.69338584
112inositol phosphate-mediated signaling (GO:0048016)2.68760793
113response to histamine (GO:0034776)2.68634522
114regulation of respiratory system process (GO:0044065)2.67660268
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.67294921
116inner ear receptor stereocilium organization (GO:0060122)2.67257878
117adult walking behavior (GO:0007628)2.67095611
118cochlea development (GO:0090102)2.65502171
119synaptic vesicle endocytosis (GO:0048488)2.64666829
120regulation of synaptic plasticity (GO:0048167)2.64231890
121neurotransmitter secretion (GO:0007269)2.64137639
122serotonin receptor signaling pathway (GO:0007210)2.63926262
123regulation of respiratory gaseous exchange (GO:0043576)2.63796795
124gamma-aminobutyric acid transport (GO:0015812)2.62335762
125membrane hyperpolarization (GO:0060081)2.61725101
126positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.61002563
127negative regulation of axon extension (GO:0030517)2.60758890
128serotonin metabolic process (GO:0042428)2.60648455
129regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.59195684
130positive regulation of action potential (GO:0045760)2.59075352
131visual learning (GO:0008542)2.58314307
132neuron remodeling (GO:0016322)2.57929902
133regulation of potassium ion transmembrane transporter activity (GO:1901016)2.57803950
134layer formation in cerebral cortex (GO:0021819)2.56677490
135positive regulation of potassium ion transport (GO:0043268)2.56319358
136detection of calcium ion (GO:0005513)2.56018879
137neurotransmitter transport (GO:0006836)2.54295084
138regulation of vesicle fusion (GO:0031338)2.54221450
139chemosensory behavior (GO:0007635)2.53936515
140adult behavior (GO:0030534)2.53347512
141potassium ion homeostasis (GO:0055075)2.52221134
142dendritic spine morphogenesis (GO:0060997)2.52202219
143synaptic transmission (GO:0007268)2.52123621
144behavioral response to ethanol (GO:0048149)2.51609823
145long term synaptic depression (GO:0060292)2.51370712
146positive regulation of dendritic spine development (GO:0060999)2.51126444
147regulation of dendritic spine morphogenesis (GO:0061001)2.49712904
148positive regulation of potassium ion transmembrane transport (GO:1901381)2.49113265
149axonal fasciculation (GO:0007413)2.48814021
150collecting duct development (GO:0072044)2.48383455
151cAMP catabolic process (GO:0006198)2.47861679
152fear response (GO:0042596)2.47033775
153associative learning (GO:0008306)2.46437539
154regulation of synapse organization (GO:0050807)2.46223618
155behavioral response to nicotine (GO:0035095)2.45753157
156cyclic nucleotide catabolic process (GO:0009214)2.44994162
157aggressive behavior (GO:0002118)2.44931882
158protein localization to cilium (GO:0061512)2.44854922
159positive regulation of synaptic transmission (GO:0050806)2.44475520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22038496
2GBX2_23144817_ChIP-Seq_PC3_Human4.47282242
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87412356
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75318985
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56923627
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54793170
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.46572363
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.38871510
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38804510
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37203527
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35273356
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32557423
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27074004
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27074004
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23885814
16TAF15_26573619_Chip-Seq_HEK293_Human2.22930782
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15719855
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11079475
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10059373
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07485989
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97652375
22REST_21632747_ChIP-Seq_MESCs_Mouse1.95222548
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95183667
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94186792
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.93779376
26P300_19829295_ChIP-Seq_ESCs_Human1.90794542
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.88219346
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88020536
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.87365895
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84030613
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.81958315
32IGF1R_20145208_ChIP-Seq_DFB_Human1.80764520
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80435108
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79548120
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77940317
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76891546
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75004217
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74407482
39SMAD4_21799915_ChIP-Seq_A2780_Human1.74308249
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72735335
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64785926
42* FUS_26573619_Chip-Seq_HEK293_Human1.62192252
43RNF2_27304074_Chip-Seq_NSC_Mouse1.61416532
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.60645516
45TP53_18474530_ChIP-ChIP_U2OS_Human1.60606190
46AR_21572438_ChIP-Seq_LNCaP_Human1.57299053
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52856688
48DROSHA_22980978_ChIP-Seq_HELA_Human1.52589831
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49649313
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.48642230
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48618306
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.47342492
53TP53_16413492_ChIP-PET_HCT116_Human1.46783492
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46766121
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46447045
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.46278785
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.44884405
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44022532
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43433215
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43122613
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41567777
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40855538
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40706801
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38307109
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37950027
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37950027
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37927132
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.37458135
69P53_22387025_ChIP-Seq_ESCs_Mouse1.35791874
70BCAT_22108803_ChIP-Seq_LS180_Human1.35037922
71* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34949423
72* REST_18959480_ChIP-ChIP_MESCs_Mouse1.30802894
73* AR_25329375_ChIP-Seq_VCAP_Human1.30485735
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28464447
75* ER_23166858_ChIP-Seq_MCF-7_Human1.28384074
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.27949834
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.26871107
78* STAT3_23295773_ChIP-Seq_U87_Human1.26592035
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25322656
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.25225420
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23784152
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.23729499
83* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21531679
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.21010074
85* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19984543
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19927214
87EWS_26573619_Chip-Seq_HEK293_Human1.19467536
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19351940
89P300_18555785_Chip-Seq_ESCs_Mouse1.19218221
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19067253
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18908966
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18246378
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18246378
94* TCF4_23295773_ChIP-Seq_U87_Human1.16996106
95CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16565658
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.15684509
97VDR_22108803_ChIP-Seq_LS180_Human1.15638712
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.15123100
99* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14608181
100RUNX2_22187159_ChIP-Seq_PCA_Human1.14448131
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.14094229
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.13860239
103RARB_27405468_Chip-Seq_BRAIN_Mouse1.13528977
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12675161
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11762299
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11705817
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11448986
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09103195
109AHR_22903824_ChIP-Seq_MCF-7_Human1.08481354
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.08233724
111SMAD3_21741376_ChIP-Seq_HESCs_Human1.08190783
112KDM2B_26808549_Chip-Seq_REH_Human1.07639157
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07336755
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07202184
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06632780
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06540303
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06453997
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05751076
119* AR_19668381_ChIP-Seq_PC3_Human1.04628944
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.04155787
121* JUN_21703547_ChIP-Seq_K562_Human1.03820623
122* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03678161
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03321774
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02799109
125SOX9_26525672_Chip-Seq_HEART_Mouse1.02335645
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01560729
127PU1_27457419_Chip-Seq_LIVER_Mouse1.00468381
128ZNF274_21170338_ChIP-Seq_K562_Hela1.00285289
129RXR_22108803_ChIP-Seq_LS180_Human0.97971053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.58164717
2MP0004859_abnormal_synaptic_plasticity4.19503460
3MP0001188_hyperpigmentation3.36100370
4MP0006292_abnormal_olfactory_placode3.18317978
5MP0003635_abnormal_synaptic_transmissio2.97998202
6MP0009745_abnormal_behavioral_response2.93889757
7MP0008438_abnormal_cutaneous_collagen2.91841030
8MP0004270_analgesia2.79088607
9MP0001968_abnormal_touch/_nociception2.69754700
10MP0001486_abnormal_startle_reflex2.50187949
11MP0002064_seizures2.48741173
12MP0002272_abnormal_nervous_system2.40001234
13MP0002063_abnormal_learning/memory/cond2.39998935
14MP0009046_muscle_twitch2.39519381
15MP0005409_darkened_coat_color2.35427785
16MP0002572_abnormal_emotion/affect_behav2.30987262
17MP0002822_catalepsy2.29243640
18MP0002734_abnormal_mechanical_nocicepti2.24159105
19MP0005646_abnormal_pituitary_gland2.23435279
20MP0005171_absent_coat_pigmentation2.18595136
21MP0002736_abnormal_nociception_after2.17317096
22MP0003136_yellow_coat_color2.12474494
23MP0003879_abnormal_hair_cell2.06856210
24MP0001501_abnormal_sleep_pattern2.06660893
25MP0006276_abnormal_autonomic_nervous2.05330862
26MP0002735_abnormal_chemical_nociception2.03022263
27MP0002067_abnormal_sensory_capabilities1.99450811
28MP0005645_abnormal_hypothalamus_physiol1.98810551
29MP0005275_abnormal_skin_tensile1.95075170
30MP0005503_abnormal_tendon_morphology1.91190411
31MP0005423_abnormal_somatic_nervous1.89486536
32MP0005623_abnormal_meninges_morphology1.81813515
33MP0001970_abnormal_pain_threshold1.69115920
34MP0001958_emphysema1.67105337
35MP0002638_abnormal_pupillary_reflex1.64746526
36MP0002733_abnormal_thermal_nociception1.63309125
37MP0001440_abnormal_grooming_behavior1.61807195
38MP0002557_abnormal_social/conspecific_i1.60144736
39MP0000778_abnormal_nervous_system1.60014638
40MP0001905_abnormal_dopamine_level1.56714413
41MP0000015_abnormal_ear_pigmentation1.55508622
42MP0010386_abnormal_urinary_bladder1.54762717
43MP0004924_abnormal_behavior1.49945542
44MP0005386_behavior/neurological_phenoty1.49945542
45MP0009697_abnormal_copulation1.49895397
46MP0002184_abnormal_innervation1.48332382
47MP0004142_abnormal_muscle_tone1.47743861
48MP0004742_abnormal_vestibular_system1.46839760
49MP0001529_abnormal_vocalization1.46104570
50MP0002876_abnormal_thyroid_physiology1.45325677
51MP0008569_lethality_at_weaning1.44409950
52MP0000566_synostosis1.42986307
53MP0001502_abnormal_circadian_rhythm1.42763488
54MP0001986_abnormal_taste_sensitivity1.39178095
55MP0001984_abnormal_olfaction1.37253632
56MP0003787_abnormal_imprinting1.36865287
57MP0001299_abnormal_eye_distance/1.36283283
58MP0000569_abnormal_digit_pigmentation1.33791311
59MP0005257_abnormal_intraocular_pressure1.33388649
60MP0000372_irregular_coat_pigmentation1.32693323
61MP0001963_abnormal_hearing_physiology1.30956829
62MP0003122_maternal_imprinting1.25511353
63MP0001485_abnormal_pinna_reflex1.24585793
64MP0005174_abnormal_tail_pigmentation1.23844116
65MP0004272_abnormal_basement_membrane1.22190350
66MP0000534_abnormal_ureter_morphology1.21738148
67MP0000013_abnormal_adipose_tissue1.19093180
68MP0008875_abnormal_xenobiotic_pharmacok1.18455012
69MP0000026_abnormal_inner_ear1.13215680
70MP0000631_abnormal_neuroendocrine_gland1.13207807
71MP0000681_abnormal_thyroid_gland1.12051937
72MP0002882_abnormal_neuron_morphology1.10656916
73MP0000955_abnormal_spinal_cord1.10276706
74MP0004145_abnormal_muscle_electrophysio1.07923576
75MP0002066_abnormal_motor_capabilities/c1.07702823
76MP0002102_abnormal_ear_morphology1.05775846
77MP0003633_abnormal_nervous_system1.01725293
78MP0005551_abnormal_eye_electrophysiolog1.01710350
79MP0003137_abnormal_impulse_conducting1.00619730
80MP0004811_abnormal_neuron_physiology0.98142173
81MP0002751_abnormal_autonomic_nervous0.97746789
82MP0009379_abnormal_foot_pigmentation0.97151333
83MP0002938_white_spotting0.96745010
84MP0004147_increased_porphyrin_level0.95877272
85MP0001664_abnormal_digestion0.95695187
86MP0002095_abnormal_skin_pigmentation0.95608416
87MP0004043_abnormal_pH_regulation0.94968266
88MP0009384_cardiac_valve_regurgitation0.94880894
89MP0000579_abnormal_nail_morphology0.94547411
90MP0003279_aneurysm0.92242185
91MP0004215_abnormal_myocardial_fiber0.89823892
92MP0002752_abnormal_somatic_nervous0.88595109
93MP0004885_abnormal_endolymph0.88452209
94MP0009250_abnormal_appendicular_skeleto0.88123387
95MP0003283_abnormal_digestive_organ0.87707771
96MP0002234_abnormal_pharynx_morphology0.87311337
97MP0002163_abnormal_gland_morphology0.85631798
98MP0002295_abnormal_pulmonary_circulatio0.84632564
99MP0002229_neurodegeneration0.84539745
100MP0002277_abnormal_respiratory_mucosa0.84423342
101MP0003631_nervous_system_phenotype0.84139263
102MP0001542_abnormal_bone_strength0.83686940
103MP0004381_abnormal_hair_follicle0.82498578
104MP0003634_abnormal_glial_cell0.81675766
105MP0005595_abnormal_vascular_smooth0.79752848
106MP0008260_abnormal_autophagy0.78924630
107MP0005379_endocrine/exocrine_gland_phen0.78829022
108MP0005075_abnormal_melanosome_morpholog0.78510831
109MP0000920_abnormal_myelination0.77827642
110MP0005187_abnormal_penis_morphology0.77030673
111MP0000049_abnormal_middle_ear0.76987148
112MP0003950_abnormal_plasma_membrane0.76692711
113MP0000678_abnormal_parathyroid_gland0.76672970
114MP0002152_abnormal_brain_morphology0.73679511
115MP0000538_abnormal_urinary_bladder0.72677309
116MP0003011_delayed_dark_adaptation0.72325888
117MP0002177_abnormal_outer_ear0.71491004
118MP0003938_abnormal_ear_development0.70910428
119MP0004085_abnormal_heartbeat0.70631596
120MP0003868_abnormal_feces_composition0.69960853
121MP0005508_abnormal_skeleton_morphology0.67944696
122MP0000003_abnormal_adipose_tissue0.67756072
123MP0002069_abnormal_eating/drinking_beha0.67351842
124MP0006035_abnormal_mitochondrial_morpho0.67220781
125MP0003941_abnormal_skin_development0.65738225
126MP0008004_abnormal_stomach_pH0.64531297
127MP0004484_altered_response_of0.64286226
128MP0008872_abnormal_physiological_respon0.63055808
129MP0002108_abnormal_muscle_morphology0.61862334
130MP0005620_abnormal_muscle_contractility0.61843369
131MP0002896_abnormal_bone_mineralization0.61814823
132MP0003878_abnormal_ear_physiology0.61467819
133MP0005377_hearing/vestibular/ear_phenot0.61467819
134MP0002249_abnormal_larynx_morphology0.61342414
135MP0001177_atelectasis0.59325593
136MP0008874_decreased_physiological_sensi0.58509905
137MP0001346_abnormal_lacrimal_gland0.56897552
138MP0009780_abnormal_chondrocyte_physiolo0.56875262

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.17391715
2Febrile seizures (HP:0002373)5.26434191
3Epileptic encephalopathy (HP:0200134)4.58378991
4Dysmetric saccades (HP:0000641)4.44435115
5Myokymia (HP:0002411)3.96386505
6Focal seizures (HP:0007359)3.83393016
7Nonprogressive disorder (HP:0003680)3.71645268
8Broad-based gait (HP:0002136)3.49101302
9Atonic seizures (HP:0010819)3.43936472
10Hypothermia (HP:0002045)3.41700602
11Horizontal nystagmus (HP:0000666)3.38292950
12Gaze-evoked nystagmus (HP:0000640)3.28808654
13Intention tremor (HP:0002080)3.28084156
14Absent/shortened dynein arms (HP:0200106)3.25911181
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.25911181
16Hyperventilation (HP:0002883)3.18232589
17Protrusio acetabuli (HP:0003179)3.17860705
18Neonatal short-limb short stature (HP:0008921)3.13217030
19Impaired vibration sensation in the lower limbs (HP:0002166)3.06972039
20Postural tremor (HP:0002174)3.05751678
21Progressive cerebellar ataxia (HP:0002073)2.98936690
22Broad metatarsal (HP:0001783)2.80612978
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.79347872
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.79347872
25Premature rupture of membranes (HP:0001788)2.76947272
26Aortic aneurysm (HP:0004942)2.75787347
27Dialeptic seizures (HP:0011146)2.74179884
28Impaired smooth pursuit (HP:0007772)2.74046144
29Abnormal hair whorl (HP:0010721)2.69526061
30Protruding tongue (HP:0010808)2.62269278
31Blue irides (HP:0000635)2.59533481
32Retinal dysplasia (HP:0007973)2.58471125
33Absence seizures (HP:0002121)2.57300288
34Atrophic scars (HP:0001075)2.56477005
35Absent speech (HP:0001344)2.54497198
36Vascular tortuosity (HP:0004948)2.54381456
37Generalized tonic-clonic seizures (HP:0002069)2.51439633
38Patchy hypopigmentation of hair (HP:0011365)2.50151486
39Abnormal ciliary motility (HP:0012262)2.47579534
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45395787
41Scanning speech (HP:0002168)2.45207060
42Inability to walk (HP:0002540)2.43893830
43Abnormality of the corticospinal tract (HP:0002492)2.42461053
44Progressive inability to walk (HP:0002505)2.42175995
45Medial flaring of the eyebrow (HP:0010747)2.41618633
46Optic nerve hypoplasia (HP:0000609)2.38684587
47Parakeratosis (HP:0001036)2.37461389
48Generalized hypopigmentation of hair (HP:0011358)2.35609305
49Fair hair (HP:0002286)2.35008744
50Gait imbalance (HP:0002141)2.33670651
51Thyroid-stimulating hormone excess (HP:0002925)2.28258484
523-Methylglutaconic aciduria (HP:0003535)2.26791447
53Abnormality of ocular smooth pursuit (HP:0000617)2.22797719
54Esotropia (HP:0000565)2.21162523
55Aortic dissection (HP:0002647)2.20447838
56Nephrogenic diabetes insipidus (HP:0009806)2.19985065
57White forelock (HP:0002211)2.19771159
58Abnormal respiratory motile cilium morphology (HP:0005938)2.15039577
59Abnormal respiratory epithelium morphology (HP:0012253)2.15039577
60Congenital primary aphakia (HP:0007707)2.12759481
61Follicular hyperkeratosis (HP:0007502)2.12423954
62Drooling (HP:0002307)2.09482751
63Excessive salivation (HP:0003781)2.09482751
64Abnormality of dentin (HP:0010299)2.08963220
65Overgrowth (HP:0001548)2.08843516
66Septo-optic dysplasia (HP:0100842)2.07645356
67Focal dystonia (HP:0004373)2.06940513
68Congenital sensorineural hearing impairment (HP:0008527)2.06878534
69Anxiety (HP:0000739)2.05411641
70True hermaphroditism (HP:0010459)2.04611818
71Rhinitis (HP:0012384)2.04180807
72Visual hallucinations (HP:0002367)2.03000217
73Absent septum pellucidum (HP:0001331)1.99744306
74Poor eye contact (HP:0000817)1.99692312
75Aplasia/Hypoplasia of the tibia (HP:0005772)1.97439602
76Type I transferrin isoform profile (HP:0003642)1.96366833
77Dysmetria (HP:0001310)1.95937724
78Arterial tortuosity (HP:0005116)1.94359028
79Shallow orbits (HP:0000586)1.92414723
80Soft skin (HP:0000977)1.90871406
81Pancreatic fibrosis (HP:0100732)1.89799393
82Absent eyebrow (HP:0002223)1.89400372
83Abnormality of saccadic eye movements (HP:0000570)1.88952167
84EEG with generalized epileptiform discharges (HP:0011198)1.88014946
85Abnormality of dental color (HP:0011073)1.88011771
86Abnormal respiratory motile cilium physiology (HP:0012261)1.86629960
87Type 2 muscle fiber atrophy (HP:0003554)1.86042364
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85559695
89Limb dystonia (HP:0002451)1.85332452
90Truncal ataxia (HP:0002078)1.85296610
91Impaired vibratory sensation (HP:0002495)1.85192081
92Diplopia (HP:0000651)1.85037034
93Abnormality of binocular vision (HP:0011514)1.85037034
94Fetal akinesia sequence (HP:0001989)1.84295239
95Widely spaced teeth (HP:0000687)1.83035238
96Nephronophthisis (HP:0000090)1.82907021
97Absent frontal sinuses (HP:0002688)1.81653284
98Agitation (HP:0000713)1.81359361
99Torticollis (HP:0000473)1.80875037
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.79927228
101Hypoplasia of the fovea (HP:0007750)1.79927228
102Genital tract atresia (HP:0001827)1.79689230
103Short tibia (HP:0005736)1.79087212
104Megalencephaly (HP:0001355)1.78717471
105Microvesicular hepatic steatosis (HP:0001414)1.76945392
106Bradycardia (HP:0001662)1.76755083
107Aplasia/Hypoplasia of the lens (HP:0008063)1.76717384
108Abnormality of the septum pellucidum (HP:0007375)1.75959578
109Abnormality of midbrain morphology (HP:0002418)1.74963241
110Molar tooth sign on MRI (HP:0002419)1.74963241
111Chronic hepatic failure (HP:0100626)1.74415885
112Bladder diverticulum (HP:0000015)1.74099594
113Vaginal atresia (HP:0000148)1.74076166
114Sleep apnea (HP:0010535)1.73998280
115Aplasia involving bones of the upper limbs (HP:0009823)1.73771642
116Aplasia of the phalanges of the hand (HP:0009802)1.73771642
117Aplasia involving bones of the extremities (HP:0009825)1.73771642
118Split foot (HP:0001839)1.73401138
119Hemiparesis (HP:0001269)1.73325568
120Mild short stature (HP:0003502)1.73129040
121Abnormality of incisor morphology (HP:0011063)1.72695403
122Bell-shaped thorax (HP:0001591)1.71890388
123Ankle contracture (HP:0006466)1.71524488
124Hyperphosphatemia (HP:0002905)1.69779233
125Dysdiadochokinesis (HP:0002075)1.69723298
126Amblyopia (HP:0000646)1.69288117
127Wormian bones (HP:0002645)1.69155167
128Cortical visual impairment (HP:0100704)1.68751757
129Gait ataxia (HP:0002066)1.67786657
130Action tremor (HP:0002345)1.67479963
131Severe visual impairment (HP:0001141)1.67102321
132Autoamputation (HP:0001218)1.66748766
133Type II lissencephaly (HP:0007260)1.65921202
134Coronal craniosynostosis (HP:0004440)1.65758343
135Delayed gross motor development (HP:0002194)1.65367295
136Wide anterior fontanel (HP:0000260)1.64253103
137Abnormality of salivation (HP:0100755)1.64056612
138Epileptiform EEG discharges (HP:0011182)1.62517202
139Cutaneous finger syndactyly (HP:0010554)1.62507744
140Hypoplasia of the iris (HP:0007676)1.62309001
141Stereotypic behavior (HP:0000733)1.61616539
142Small hand (HP:0200055)1.61386210
143Buphthalmos (HP:0000557)1.61290755
144Syncope (HP:0001279)1.61263458
145Mutism (HP:0002300)1.61050412
146Neurofibrillary tangles (HP:0002185)1.60445911
147Abnormality of the fovea (HP:0000493)1.59934000
148Heterochromia iridis (HP:0001100)1.59365320
149Decreased central vision (HP:0007663)1.59109341
150Ankle clonus (HP:0011448)1.59070753
151Abnormal eating behavior (HP:0100738)1.58359004
152Slender build (HP:0001533)1.57951163
153Conical tooth (HP:0000698)1.57867904
154Depression (HP:0000716)1.57222918
155Abnormality of secondary sexual hair (HP:0009888)1.57190298
156Abnormality of the axillary hair (HP:0100134)1.57190298
157Status epilepticus (HP:0002133)1.56096425
158Prolonged QT interval (HP:0001657)1.52335924
159Supranuclear gaze palsy (HP:0000605)1.52303119
160Occipital encephalocele (HP:0002085)1.50114691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.51582306
2TNIK4.05471655
3MUSK3.65182998
4NTRK33.34938130
5MAP2K73.23490906
6PNCK2.79945148
7EPHA42.73571965
8PRPF4B2.53123477
9MYLK2.33808924
10MAP3K122.28783133
11MAPK131.94519359
12MKNK21.84734052
13MAP3K41.82999420
14CDK191.82674400
15SIK31.74884765
16RIPK41.73035814
17LATS11.63468906
18BMPR21.59799433
19PDGFRA1.48639291
20MARK11.43000223
21PAK31.40885205
22FGFR21.36541154
23DAPK21.36324296
24NTRK21.33975637
25AKT31.30966032
26NEK61.30746253
27LATS21.25410023
28DDR21.25330704
29GRK71.25020251
30CAMK1G1.24079747
31FRK1.23963466
32CAMKK21.20005577
33PLK21.19463162
34OXSR11.19196722
35SIK21.18433286
36PRKD31.18093709
37CCNB11.16801197
38ADRBK21.16599855
39TXK1.16553058
40MAP3K131.16532229
41PINK11.16269213
42ROCK21.11251097
43GRK51.11176763
44INSRR1.10953946
45NTRK11.07705052
46WNK11.06738109
47MKNK11.06288741
48MINK11.04006705
49CAMK11.03456469
50MAPKAPK51.03049266
51DAPK11.02800414
52SGK21.01391820
53CDK81.01090567
54CDK31.00365185
55STK161.00221269
56TNK20.99383347
57SGK4940.97954325
58SGK2230.97954325
59CAMK2A0.96119227
60CDK50.94065044
61MAP2K40.91825510
62IRAK20.91096035
63BMPR1B0.88847946
64CAMK2B0.88600729
65MET0.88490300
66EPHA30.88246891
67PTK20.87178104
68YES10.86004594
69UHMK10.85574155
70FER0.84741326
71PTK2B0.84462931
72FES0.83873285
73MAPK150.83288711
74PRKCG0.83279426
75PRKCE0.83122208
76SRPK10.83061393
77PDGFRB0.82605745
78ROCK10.82184384
79EPHB20.81424076
80PRKCH0.79277443
81MAP3K90.76799532
82CSNK1G20.69568383
83TIE10.69342508
84PHKG20.69137350
85PHKG10.69137350
86STK38L0.68799292
87PRKD20.67628813
88BRAF0.64457737
89IRAK40.64412774
90GRK10.64141495
91NEK90.63314866
92CSNK1G10.62360799
93DYRK1A0.62270285
94WNK30.60068014
95PAK20.58213148
96TAOK20.58157935
97CSNK1G30.55898037
98CAMKK10.55231264
99PKN10.54647434
100TYRO30.54625665
101SGK10.53844906
102MAP2K60.53408708
103CLK10.53381338
104MAP2K10.52426583
105BCR0.51715062
106TEC0.51709426
107ILK0.51127531
108EIF2AK20.51021867
109CAMK2D0.50816063
110RPS6KA30.50810071
111DMPK0.49618749
112PRKCA0.49447347
113ADRBK10.49298331
114TESK10.47754344
115MAPK120.46618103
116SGK30.45956823
117PRKG10.45834668
118FYN0.45596577
119PRKCZ0.44433806
120STK110.44383527
121STK380.43769058
122CSNK1A1L0.43715403
123STK390.42780635
124WNK40.41595097
125MAP3K20.41485221
126MAP3K140.40377966
127NME10.40293792
128KSR20.39884124
129CSNK1D0.39615657
130KSR10.39469501
131ZAK0.38980264
132MAPK70.38889145
133MARK20.38356793
134PRKG20.38332032
135MAP3K60.38092490
136IRAK30.37742122
137CAMK40.36674002
138PRKACA0.36314235
139ARAF0.34114362
140ERBB30.33101734
141CAMK2G0.33076593
142CSNK1A10.32945929
143SYK0.32074877
144PAK60.31568896
145DYRK20.31342103

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.10299838
2Nitrogen metabolism_Homo sapiens_hsa009102.79080605
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77559381
4Morphine addiction_Homo sapiens_hsa050322.66014340
5Synaptic vesicle cycle_Homo sapiens_hsa047212.61300269
6Olfactory transduction_Homo sapiens_hsa047402.60304870
7Circadian entrainment_Homo sapiens_hsa047132.58467172
8Glutamatergic synapse_Homo sapiens_hsa047242.51076628
9GABAergic synapse_Homo sapiens_hsa047272.39463017
10Taste transduction_Homo sapiens_hsa047422.27411243
11Serotonergic synapse_Homo sapiens_hsa047262.16212391
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13232221
13Long-term potentiation_Homo sapiens_hsa047202.03513204
14Amphetamine addiction_Homo sapiens_hsa050312.00680865
15Salivary secretion_Homo sapiens_hsa049701.98816320
16Long-term depression_Homo sapiens_hsa047301.91642661
17Collecting duct acid secretion_Homo sapiens_hsa049661.79599597
18Dopaminergic synapse_Homo sapiens_hsa047281.72517151
19Calcium signaling pathway_Homo sapiens_hsa040201.72015441
20Insulin secretion_Homo sapiens_hsa049111.70952688
21Renin secretion_Homo sapiens_hsa049241.68560416
22Cholinergic synapse_Homo sapiens_hsa047251.66711323
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.57752369
24Cocaine addiction_Homo sapiens_hsa050301.53167048
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48983882
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47112466
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38574732
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33670996
29ECM-receptor interaction_Homo sapiens_hsa045121.30502535
30Phototransduction_Homo sapiens_hsa047441.30147002
31Oxytocin signaling pathway_Homo sapiens_hsa049211.26843357
32Gastric acid secretion_Homo sapiens_hsa049711.24158739
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22261339
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19692242
35cAMP signaling pathway_Homo sapiens_hsa040241.16324981
36Axon guidance_Homo sapiens_hsa043601.15903949
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14128529
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06662308
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06625098
40Rheumatoid arthritis_Homo sapiens_hsa053231.06291208
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04134176
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01939047
43Vibrio cholerae infection_Homo sapiens_hsa051101.01114240
44GnRH signaling pathway_Homo sapiens_hsa049120.99134515
45African trypanosomiasis_Homo sapiens_hsa051430.97220205
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95601301
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93452985
48Gap junction_Homo sapiens_hsa045400.93066968
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92998465
50Oxidative phosphorylation_Homo sapiens_hsa001900.92918070
51Melanogenesis_Homo sapiens_hsa049160.92248400
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.92245524
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91892404
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89499215
55Type I diabetes mellitus_Homo sapiens_hsa049400.87129131
56Sphingolipid metabolism_Homo sapiens_hsa006000.85638399
57Ovarian steroidogenesis_Homo sapiens_hsa049130.84512347
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84399908
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81928437
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81077638
61ErbB signaling pathway_Homo sapiens_hsa040120.81025703
62Alzheimers disease_Homo sapiens_hsa050100.79793062
63Circadian rhythm_Homo sapiens_hsa047100.74815349
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74266449
65Pancreatic secretion_Homo sapiens_hsa049720.74261298
66Protein digestion and absorption_Homo sapiens_hsa049740.74169341
67Focal adhesion_Homo sapiens_hsa045100.74001817
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72832854
69Dorso-ventral axis formation_Homo sapiens_hsa043200.71496534
70Wnt signaling pathway_Homo sapiens_hsa043100.71199422
71Ras signaling pathway_Homo sapiens_hsa040140.66536012
72Hippo signaling pathway_Homo sapiens_hsa043900.65589364
73Ether lipid metabolism_Homo sapiens_hsa005650.65229215
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64283393
75Protein export_Homo sapiens_hsa030600.62569310
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62119149
77MAPK signaling pathway_Homo sapiens_hsa040100.59687706
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59463913
79Hedgehog signaling pathway_Homo sapiens_hsa043400.59094710
80Cardiac muscle contraction_Homo sapiens_hsa042600.58913133
81Glioma_Homo sapiens_hsa052140.58544871
82Regulation of autophagy_Homo sapiens_hsa041400.57792766
83Parkinsons disease_Homo sapiens_hsa050120.56759980
84Autoimmune thyroid disease_Homo sapiens_hsa053200.56645711
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.55933395
86Prion diseases_Homo sapiens_hsa050200.55820937
87Allograft rejection_Homo sapiens_hsa053300.55600192
88Glucagon signaling pathway_Homo sapiens_hsa049220.55458168
89Amoebiasis_Homo sapiens_hsa051460.55303048
90Butanoate metabolism_Homo sapiens_hsa006500.54865672
91Mineral absorption_Homo sapiens_hsa049780.54759576
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.52285010
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.52267584
94Basal cell carcinoma_Homo sapiens_hsa052170.50506000
95Basal transcription factors_Homo sapiens_hsa030220.48962707
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48126697
97Bile secretion_Homo sapiens_hsa049760.48080647
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47955784
99Alcoholism_Homo sapiens_hsa050340.47536058
100Huntingtons disease_Homo sapiens_hsa050160.46310958
101Glycerolipid metabolism_Homo sapiens_hsa005610.46057521
102Inositol phosphate metabolism_Homo sapiens_hsa005620.45948944
103Type II diabetes mellitus_Homo sapiens_hsa049300.45489409
104Proteoglycans in cancer_Homo sapiens_hsa052050.44645032
105Tight junction_Homo sapiens_hsa045300.43884809
106Estrogen signaling pathway_Homo sapiens_hsa049150.43763209
107ABC transporters_Homo sapiens_hsa020100.42503172
108Chemokine signaling pathway_Homo sapiens_hsa040620.41473909
109Graft-versus-host disease_Homo sapiens_hsa053320.41090543
110Phagosome_Homo sapiens_hsa041450.40946906
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40540233
112Retinol metabolism_Homo sapiens_hsa008300.40024315
113Chemical carcinogenesis_Homo sapiens_hsa052040.40009709
114Rap1 signaling pathway_Homo sapiens_hsa040150.37931976
115Renin-angiotensin system_Homo sapiens_hsa046140.37902767
116Asthma_Homo sapiens_hsa053100.37896252
117TGF-beta signaling pathway_Homo sapiens_hsa043500.37657547
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37308758
119Choline metabolism in cancer_Homo sapiens_hsa052310.37144564
120Histidine metabolism_Homo sapiens_hsa003400.36844405
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35877996
122Oocyte meiosis_Homo sapiens_hsa041140.35498416
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34497772
124Arachidonic acid metabolism_Homo sapiens_hsa005900.34219831
125RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33177952
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33121854
127Dilated cardiomyopathy_Homo sapiens_hsa054140.33099438
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32414563
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32329930
130Fanconi anemia pathway_Homo sapiens_hsa034600.32062330
131Melanoma_Homo sapiens_hsa052180.31662246
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31633583
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31424987
134Thyroid hormone synthesis_Homo sapiens_hsa049180.30503932
135Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29326598
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29321784
137Purine metabolism_Homo sapiens_hsa002300.28935384

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