CNTNAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the NCP family of cell-recognition molecules. This family represents a distinct subgroup of the neurexins. NCP proteins mediate neuron-glial interactions in vertebrates and glial-glial contact in invertebrates. The protein encoded by this gene may play a role in cell recognition within the nervous system. Alternatively spliced transcript variants encoding different isoforms have been described but their biological nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.19009362
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.75958308
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63170954
4synaptic vesicle maturation (GO:0016188)5.52752706
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.41662218
6locomotory exploration behavior (GO:0035641)5.38174464
7synaptic vesicle exocytosis (GO:0016079)5.32568189
8neuron cell-cell adhesion (GO:0007158)5.32363029
9regulation of glutamate receptor signaling pathway (GO:1900449)5.30403858
10neural tube formation (GO:0001841)5.06736357
11regulation of synapse structural plasticity (GO:0051823)5.05838691
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98570966
13regulation of synaptic vesicle exocytosis (GO:2000300)4.87105964
14glutamate secretion (GO:0014047)4.78270015
15protein localization to synapse (GO:0035418)4.76077063
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.72967291
17neurotransmitter secretion (GO:0007269)4.61762387
18positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.58589383
19gamma-aminobutyric acid transport (GO:0015812)4.49619277
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49404972
21neurotransmitter-gated ion channel clustering (GO:0072578)4.47903771
22detection of molecule of bacterial origin (GO:0032490)4.45162663
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.39206191
24striatum development (GO:0021756)4.34501904
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.33204271
26positive regulation by symbiont of host defense response (GO:0052509)4.31160518
27modulation by symbiont of host defense response (GO:0052031)4.31160518
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.31160518
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.31160518
30positive regulation by organism of defense response of other organism involved in symbiotic interact4.31160518
31modulation by symbiont of host immune response (GO:0052553)4.31160518
32regulation of synaptic vesicle transport (GO:1902803)4.29070274
33ionotropic glutamate receptor signaling pathway (GO:0035235)4.27853632
34regulation of neuronal synaptic plasticity (GO:0048168)4.25364852
35layer formation in cerebral cortex (GO:0021819)4.24566088
36exploration behavior (GO:0035640)4.22214278
37proline transport (GO:0015824)4.18653136
38neuronal action potential propagation (GO:0019227)4.14967207
39neuron-neuron synaptic transmission (GO:0007270)4.07871178
40synaptic transmission, glutamatergic (GO:0035249)4.06866034
41regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.98249135
42regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.98249135
43prepulse inhibition (GO:0060134)3.95409976
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.81051089
45positive regulation of neurotransmitter transport (GO:0051590)3.79261492
46transmission of nerve impulse (GO:0019226)3.79260428
47positive regulation of membrane potential (GO:0045838)3.76625463
48neuron recognition (GO:0008038)3.75679048
49microglial cell activation (GO:0001774)3.75010727
50regulation of synaptic transmission, glutamatergic (GO:0051966)3.74834368
51dendritic spine morphogenesis (GO:0060997)3.74149482
52adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.72839578
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72748543
54glutamate receptor signaling pathway (GO:0007215)3.72483004
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.70242952
56activation of protein kinase A activity (GO:0034199)3.68623753
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66633349
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.66094963
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.63962699
60long-term memory (GO:0007616)3.62173703
61regulation of synaptic transmission, dopaminergic (GO:0032225)3.61684538
62neurotransmitter transport (GO:0006836)3.60028916
63regulation of synaptic transmission, GABAergic (GO:0032228)3.59992380
64regulation of dendritic spine morphogenesis (GO:0061001)3.58598132
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56925899
66neuromuscular process controlling balance (GO:0050885)3.55589129
67auditory behavior (GO:0031223)3.53686577
68positive regulation of synapse maturation (GO:0090129)3.52665355
69regulation of synaptic plasticity (GO:0048167)3.52651360
70dopamine receptor signaling pathway (GO:0007212)3.47976238
71neuronal ion channel clustering (GO:0045161)3.46584164
72response to auditory stimulus (GO:0010996)3.43920589
73axonal fasciculation (GO:0007413)3.42350689
74negative regulation of dendrite development (GO:2000171)3.41926299
75regulation of interferon-beta biosynthetic process (GO:0045357)3.41809739
76long-term synaptic potentiation (GO:0060291)3.41689049
77response to histamine (GO:0034776)3.39202374
78behavioral response to nicotine (GO:0035095)3.38139358
79regulation of neurotransmitter levels (GO:0001505)3.38030731
80neutrophil mediated immunity (GO:0002446)3.37798330
81regulation of translation, ncRNA-mediated (GO:0045974)3.37515771
82negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.37515771
83negative regulation of translation, ncRNA-mediated (GO:0040033)3.37515771
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.34516613
85cell migration in hindbrain (GO:0021535)3.34440579
86regulation of neurotransmitter uptake (GO:0051580)3.33217387
87regulation of postsynaptic membrane potential (GO:0060078)3.32851342
88leukocyte migration involved in inflammatory response (GO:0002523)3.32124386
89postsynaptic membrane organization (GO:0001941)3.31267048
90negative regulation of dendrite morphogenesis (GO:0050774)3.30287626
91cilium or flagellum-dependent cell motility (GO:0001539)3.29340322
92regulation of hippo signaling (GO:0035330)3.26826116
93behavioral response to cocaine (GO:0048148)3.26472418
94neuromuscular process controlling posture (GO:0050884)3.25378229
95regulation of female receptivity (GO:0045924)3.24877131
96learning (GO:0007612)3.21018181
97limb bud formation (GO:0060174)3.20933063
98regulation of posttranscriptional gene silencing (GO:0060147)3.20648475
99regulation of gene silencing by miRNA (GO:0060964)3.20648475
100regulation of gene silencing by RNA (GO:0060966)3.20648475
101negative regulation of cAMP-mediated signaling (GO:0043951)3.20361147
102regulation of neurotransmitter transport (GO:0051588)3.20141249
103gamma-aminobutyric acid signaling pathway (GO:0007214)3.19979546
104negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19114643
105regulation of glutamate secretion (GO:0014048)3.17986065
106synapse assembly (GO:0007416)3.17601861
107membrane depolarization during action potential (GO:0086010)3.16165256
108pantothenate metabolic process (GO:0015939)3.15647455
109regulation of neurotransmitter secretion (GO:0046928)3.15447481
110glycine transport (GO:0015816)3.13139786
111positive regulation of synaptic transmission (GO:0050806)3.12655242
112negative regulation of Rho protein signal transduction (GO:0035024)3.12166344
113neuromuscular process (GO:0050905)3.12081569
114fucose catabolic process (GO:0019317)3.11721237
115L-fucose metabolic process (GO:0042354)3.11721237
116L-fucose catabolic process (GO:0042355)3.11721237
117synaptic transmission, dopaminergic (GO:0001963)3.10476473
118behavioral defense response (GO:0002209)3.09686206
119behavioral fear response (GO:0001662)3.09686206
120epithelial cilium movement (GO:0003351)3.08754141
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08086907
122social behavior (GO:0035176)3.07863675
123intraspecies interaction between organisms (GO:0051703)3.07863675
124regulation of interleukin-6 biosynthetic process (GO:0045408)3.07003409
125cilium movement (GO:0003341)3.06255628
126synaptic transmission (GO:0007268)3.05218739
127synaptic vesicle endocytosis (GO:0048488)3.03834600
128female mating behavior (GO:0060180)3.02389204
129membrane hyperpolarization (GO:0060081)3.02128493
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.02000644
131regulation of cAMP-dependent protein kinase activity (GO:2000479)3.01466005
132membrane depolarization (GO:0051899)3.01035820
133positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00416168
134regulation of protein kinase A signaling (GO:0010738)3.00122389
135negative regulation of interleukin-1 production (GO:0032692)2.99358341
136positive regulation of oligodendrocyte differentiation (GO:0048714)2.95181068
137interkinetic nuclear migration (GO:0022027)2.94045231
138macrophage activation involved in immune response (GO:0002281)2.91829384
139response to host immune response (GO:0052572)2.91303992
140response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91303992
141macrophage activation (GO:0042116)2.90544234
142presynaptic membrane assembly (GO:0097105)2.86792627
143cytoplasmic mRNA processing body assembly (GO:0033962)2.85899975
144olfactory bulb development (GO:0021772)2.84217849
145positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.82481429
146establishment of protein localization to Golgi (GO:0072600)2.76681919
147pyrimidine nucleobase catabolic process (GO:0006208)2.75672831
148nonmotile primary cilium assembly (GO:0035058)2.74558588
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74246886
150response to host (GO:0075136)2.71233641
151response to host defenses (GO:0052200)2.71233641
152response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71233641
153negative regulation of immunoglobulin mediated immune response (GO:0002890)2.70394496
154negative regulation of B cell mediated immunity (GO:0002713)2.70394496
155histone-serine phosphorylation (GO:0035404)2.67550388
156superoxide anion generation (GO:0042554)2.58478330
157cell proliferation in forebrain (GO:0021846)2.58111669
158indolalkylamine metabolic process (GO:0006586)2.56787138
159kidney morphogenesis (GO:0060993)2.55553118
160retinal ganglion cell axon guidance (GO:0031290)2.55011948
161cilium organization (GO:0044782)2.54810718
162myeloid leukocyte mediated immunity (GO:0002444)2.53787349
163regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.52786321
164plasma membrane repair (GO:0001778)2.52403866
165neuronal stem cell maintenance (GO:0097150)2.52352868
166cilium morphogenesis (GO:0060271)2.52200564
167I-kappaB phosphorylation (GO:0007252)2.52099068
168histone mRNA catabolic process (GO:0071044)2.51739253
169lateral sprouting from an epithelium (GO:0060601)2.50994837
170embryonic epithelial tube formation (GO:0001838)2.49877561
171neutrophil activation (GO:0042119)2.49339730
172cellular extravasation (GO:0045123)2.47453298
173cilium assembly (GO:0042384)2.47402199
174positive regulation of action potential (GO:0045760)2.47370728
175protein targeting to Golgi (GO:0000042)2.47004594
176alkaloid metabolic process (GO:0009820)2.46752176
177detection of external biotic stimulus (GO:0098581)2.44865306
178epithelial tube formation (GO:0072175)2.44762271
179negative regulation of interleukin-1 beta production (GO:0032691)2.44130278
180nucleus localization (GO:0051647)2.43997184
181cAMP catabolic process (GO:0006198)2.42782894
182axonemal dynein complex assembly (GO:0070286)2.42673556
183sulfation (GO:0051923)2.42649308
184tryptophan metabolic process (GO:0006568)2.42626724
185protein K11-linked deubiquitination (GO:0035871)2.40715504
186presynaptic membrane organization (GO:0097090)2.40618390
187response to pheromone (GO:0019236)2.39820411
188protein localization to cilium (GO:0061512)2.39560801
189regulation of sequestering of triglyceride (GO:0010889)2.36401008
190phosphatidylinositol acyl-chain remodeling (GO:0036149)2.35664157
191cerebral cortex radially oriented cell migration (GO:0021799)2.35645571
192behavioral response to ethanol (GO:0048149)2.35014966
193adaptation of signaling pathway (GO:0023058)2.34610846
194kynurenine metabolic process (GO:0070189)2.34596586
195regulation of oligodendrocyte differentiation (GO:0048713)2.33884082
196regulation of memory T cell differentiation (GO:0043380)2.33104552
197positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.33083939
198photoreceptor cell maintenance (GO:0045494)2.31257250
199indolalkylamine catabolic process (GO:0046218)2.30473579
200tryptophan catabolic process (GO:0006569)2.30473579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86889425
2* GBX2_23144817_ChIP-Seq_PC3_Human3.99497864
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06433839
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95559272
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.86872555
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85698383
7REST_21632747_ChIP-Seq_MESCs_Mouse2.75786195
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.74998706
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.72680587
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.72019779
11VDR_22108803_ChIP-Seq_LS180_Human2.57239190
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.49495221
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48530329
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48530329
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48315718
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43441370
17DROSHA_22980978_ChIP-Seq_HELA_Human2.38891341
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35642633
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35595076
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32939628
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32067493
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.31743562
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28867698
24AR_21572438_ChIP-Seq_LNCaP_Human2.28545974
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21565570
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10247947
27TAF15_26573619_Chip-Seq_HEK293_Human2.07116985
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.06868651
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.03412798
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02815355
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99085265
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.94626937
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91139388
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.87692047
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85490489
36TP53_16413492_ChIP-PET_HCT116_Human1.82502461
37SMAD4_21799915_ChIP-Seq_A2780_Human1.80483790
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79791892
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76842652
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70517107
41EWS_26573619_Chip-Seq_HEK293_Human1.69765026
42BCAT_22108803_ChIP-Seq_LS180_Human1.67564593
43* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67131091
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61705264
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59920880
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55966623
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53825518
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51672965
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.50778171
50P300_19829295_ChIP-Seq_ESCs_Human1.49076220
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47185324
52ZNF274_21170338_ChIP-Seq_K562_Hela1.44210377
53STAT3_23295773_ChIP-Seq_U87_Human1.40534644
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.39716021
55AR_25329375_ChIP-Seq_VCAP_Human1.38194833
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37791989
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36408764
58RNF2_27304074_Chip-Seq_NSC_Mouse1.35613147
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34396605
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33908362
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.33385320
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.33233086
63IGF1R_20145208_ChIP-Seq_DFB_Human1.33020160
64TCF4_22108803_ChIP-Seq_LS180_Human1.32825928
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29445559
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28866469
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.28214743
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25758995
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25742159
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.24634770
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24508989
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24438024
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23279840
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.23187793
75AR_19668381_ChIP-Seq_PC3_Human1.21956156
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21698783
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20579579
78TCF4_23295773_ChIP-Seq_U87_Human1.20509584
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20293718
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19293783
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19197803
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19073667
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18584393
84CBP_20019798_ChIP-Seq_JUKART_Human1.18374662
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18374662
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17539640
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17028554
88* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16687431
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.15944069
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15875798
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14872066
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14852418
93* CJUN_26792858_Chip-Seq_BT549_Human1.13539803
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.12997877
95TP63_23658742_ChIP-Seq_EP156T_Human1.09442295
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09016879
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08878275
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08252127
99FUS_26573619_Chip-Seq_HEK293_Human1.08250329
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07835958
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.07687291
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07638570
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06346182
104RXR_22108803_ChIP-Seq_LS180_Human1.06334403
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06114331
106AHR_22903824_ChIP-Seq_MCF-7_Human1.05823474
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05309803
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05195441
109JUN_21703547_ChIP-Seq_K562_Human1.04915053
110RUNX2_22187159_ChIP-Seq_PCA_Human1.04687436
111DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04355133
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03824457
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.01312916
114TP53_22573176_ChIP-Seq_HFKS_Human1.00534544
115NANOG_19829295_ChIP-Seq_ESCs_Human1.00434849
116SOX2_19829295_ChIP-Seq_ESCs_Human1.00434849
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00243380
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99704174
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99529019
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.99277424
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99212855
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99185064
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99185064
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99125621
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98971857
126* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98618191
127CDX2_22108803_ChIP-Seq_LS180_Human0.98099803
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.97316003
129ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96626660
130OCT1_27270436_Chip-Seq_PROSTATE_Human0.96404029
131P53_22387025_ChIP-Seq_ESCs_Mouse0.96057982
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95156038
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94819142
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94819142
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94506053
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93387098
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.93064659
138RING1B_27294783_Chip-Seq_NPCs_Mouse0.92341668
139KDM2B_26808549_Chip-Seq_REH_Human0.91997887
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.91610872
141ER_23166858_ChIP-Seq_MCF-7_Human0.90684205
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88908061
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.88816351
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.88202869
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86770476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.01623156
2MP0002822_catalepsy5.55493546
3MP0003724_increased_susceptibility_to4.27114824
4MP0003635_abnormal_synaptic_transmissio4.11735936
5MP0004270_analgesia3.87858058
6MP0003880_abnormal_central_pattern3.82920907
7MP0009046_muscle_twitch3.54191804
8MP0009745_abnormal_behavioral_response3.50448754
9MP0002063_abnormal_learning/memory/cond3.41829268
10MP0003136_yellow_coat_color3.39349144
11MP0000566_synostosis3.29709555
12MP0002064_seizures3.13262238
13MP0002572_abnormal_emotion/affect_behav2.87526199
14MP0001968_abnormal_touch/_nociception2.84283351
15MP0005423_abnormal_somatic_nervous2.76707178
16MP0002734_abnormal_mechanical_nocicepti2.75990528
17MP0005248_abnormal_Harderian_gland2.65179629
18MP0001486_abnormal_startle_reflex2.64295229
19MP0002272_abnormal_nervous_system2.54512361
20MP0000427_abnormal_hair_cycle2.52126620
21MP0002735_abnormal_chemical_nociception2.37311497
22MP0010030_abnormal_orbit_morphology2.29376918
23MP0002736_abnormal_nociception_after2.26508784
24MP0001501_abnormal_sleep_pattern2.14234019
25MP0005646_abnormal_pituitary_gland2.11274702
26MP0003787_abnormal_imprinting2.11195619
27MP0000383_abnormal_hair_follicle2.10805588
28MP0005174_abnormal_tail_pigmentation2.10173908
29MP0003890_abnormal_embryonic-extraembry2.10104367
30MP0002733_abnormal_thermal_nociception2.08538146
31MP0002277_abnormal_respiratory_mucosa2.07676650
32MP0001529_abnormal_vocalization2.01073094
33MP0001970_abnormal_pain_threshold1.97723357
34MP0005386_behavior/neurological_phenoty1.88923253
35MP0004924_abnormal_behavior1.88923253
36MP0006292_abnormal_olfactory_placode1.87856492
37MP0005377_hearing/vestibular/ear_phenot1.83962501
38MP0003878_abnormal_ear_physiology1.83962501
39MP0004811_abnormal_neuron_physiology1.82923892
40MP0003195_calcinosis1.82724620
41MP0001440_abnormal_grooming_behavior1.80427623
42MP0002067_abnormal_sensory_capabilities1.78807224
43MP0002928_abnormal_bile_duct1.77689276
44MP0002557_abnormal_social/conspecific_i1.75346361
45MP0001984_abnormal_olfaction1.72151392
46MP0002909_abnormal_adrenal_gland1.71295326
47MP0002184_abnormal_innervation1.70707577
48MP0009780_abnormal_chondrocyte_physiolo1.70045940
49MP0004133_heterotaxia1.65222289
50MP0005171_absent_coat_pigmentation1.65123865
51MP0003879_abnormal_hair_cell1.62593181
52MP0000778_abnormal_nervous_system1.62420887
53MP0005645_abnormal_hypothalamus_physiol1.62351169
54MP0008569_lethality_at_weaning1.61436273
55MP0006276_abnormal_autonomic_nervous1.61077936
56MP0004130_abnormal_muscle_cell1.59604223
57MP0004381_abnormal_hair_follicle1.58737254
58MP0003045_fibrosis1.55312895
59MP0003329_amyloid_beta_deposits1.54017588
60MP0004484_altered_response_of1.53944694
61MP0004858_abnormal_nervous_system1.53605343
62MP0000955_abnormal_spinal_cord1.47701768
63MP0010678_abnormal_skin_adnexa1.44558496
64MP0005253_abnormal_eye_physiology1.44421429
65MP0002066_abnormal_motor_capabilities/c1.41205422
66MP0003122_maternal_imprinting1.40605936
67MP0000015_abnormal_ear_pigmentation1.38734621
68MP0005167_abnormal_blood-brain_barrier1.37444984
69MP0002882_abnormal_neuron_morphology1.36663643
70MP0000579_abnormal_nail_morphology1.36583243
71MP0001324_abnormal_eye_pigmentation1.34451956
72MP0001293_anophthalmia1.33618705
73MP0002332_abnormal_exercise_endurance1.33285860
74MP0003937_abnormal_limbs/digits/tail_de1.33160123
75MP0008789_abnormal_olfactory_epithelium1.33042347
76MP0000647_abnormal_sebaceous_gland1.31772053
77MP0001188_hyperpigmentation1.26419324
78MP0002282_abnormal_trachea_morphology1.25381203
79MP0004142_abnormal_muscle_tone1.25052696
80MP0001905_abnormal_dopamine_level1.24548928
81MP0001286_abnormal_eye_development1.21912961
82MP0004885_abnormal_endolymph1.19936188
83MP0002095_abnormal_skin_pigmentation1.18647938
84MP0003252_abnormal_bile_duct1.14968345
85MP0000751_myopathy1.12640637
86MP0003011_delayed_dark_adaptation1.12062827
87MP0005195_abnormal_posterior_eye1.11082999
88MP0002152_abnormal_brain_morphology1.10824845
89MP0003633_abnormal_nervous_system1.10475356
90MP0000569_abnormal_digit_pigmentation1.08895999
91MP0009764_decreased_sensitivity_to1.08431086
92MP0002938_white_spotting1.07638145
93MP0002233_abnormal_nose_morphology1.07498166
94MP0001177_atelectasis1.02162336
95MP0004883_abnormal_blood_vessel1.01185108
96MP0000371_diluted_coat_color1.00823643
97MP0003631_nervous_system_phenotype0.99549328
98MP0002168_other_aberrant_phenotype0.98440944
99MP0008877_abnormal_DNA_methylation0.98057542
100MP0003119_abnormal_digestive_system0.97681379
101MP0002837_dystrophic_cardiac_calcinosis0.97672882
102MP0003646_muscle_fatigue0.97382742
103MP0003828_pulmonary_edema0.97138697
104MP0000049_abnormal_middle_ear0.95518317
105MP0000631_abnormal_neuroendocrine_gland0.95064765
106MP0003283_abnormal_digestive_organ0.93642903
107MP0002069_abnormal_eating/drinking_beha0.93294304
108MP0005394_taste/olfaction_phenotype0.93043390
109MP0005499_abnormal_olfactory_system0.93043390
110MP0005084_abnormal_gallbladder_morpholo0.92340725
111MP0005164_abnormal_response_to0.90535161
112MP0005391_vision/eye_phenotype0.90397859
113MP0001502_abnormal_circadian_rhythm0.89025753
114MP0008872_abnormal_physiological_respon0.87436039
115MP0002229_neurodegeneration0.86706165
116MP0004085_abnormal_heartbeat0.86032596
117MP0008874_decreased_physiological_sensi0.85609298
118MP0003123_paternal_imprinting0.84956781
119MP0000013_abnormal_adipose_tissue0.83289576
120MP0000026_abnormal_inner_ear0.81846114
121MP0003121_genomic_imprinting0.80006058
122MP0006072_abnormal_retinal_apoptosis0.79470879
123MP0000428_abnormal_craniofacial_morphol0.79400322
124MP0002102_abnormal_ear_morphology0.78959245
125MP0000470_abnormal_stomach_morphology0.77919161
126MP0005075_abnormal_melanosome_morpholog0.75519735
127MP0001963_abnormal_hearing_physiology0.75430898
128MP0003938_abnormal_ear_development0.74827265
129MP0003632_abnormal_nervous_system0.73709084
130MP0002876_abnormal_thyroid_physiology0.73620051
131MP0004233_abnormal_muscle_weight0.72620769
132MP0003950_abnormal_plasma_membrane0.72246127
133MP0005535_abnormal_body_temperature0.71345653
134MP0010386_abnormal_urinary_bladder0.70878014
135MP0002752_abnormal_somatic_nervous0.70700766
136MP0002751_abnormal_autonomic_nervous0.69951365
137MP0008961_abnormal_basal_metabolism0.68561754
138MP0002075_abnormal_coat/hair_pigmentati0.67446489
139MP0004145_abnormal_muscle_electrophysio0.66808855
140MP0005187_abnormal_penis_morphology0.66245555
141MP0003935_abnormal_craniofacial_develop0.65805199
142MP0001485_abnormal_pinna_reflex0.65765358
143MP0003137_abnormal_impulse_conducting0.65538022
144MP0003634_abnormal_glial_cell0.65510628
145MP0005595_abnormal_vascular_smooth0.64187103
146MP0000465_gastrointestinal_hemorrhage0.63867166
147MP0008057_abnormal_DNA_replication0.63646653
148MP0002653_abnormal_ependyma_morphology0.63000446
149MP0003755_abnormal_palate_morphology0.62751849
150MP0003943_abnormal_hepatobiliary_system0.62411714
151MP0001986_abnormal_taste_sensitivity0.62304444
152MP0000604_amyloidosis0.61444942
153MP0001664_abnormal_digestion0.60596183
154MP0005409_darkened_coat_color0.59764078
155MP0001299_abnormal_eye_distance/0.59061591
156MP0003861_abnormal_nervous_system0.58479870
157MP0005551_abnormal_eye_electrophysiolog0.57503575
158MP0001348_abnormal_lacrimal_gland0.56159646
159MP0010770_preweaning_lethality0.55068402
160MP0002082_postnatal_lethality0.55068402
161MP0010769_abnormal_survival0.54812804
162MP0002638_abnormal_pupillary_reflex0.54069227
163MP0001943_abnormal_respiration0.53043757
164MP0004215_abnormal_myocardial_fiber0.52991788
165MP0004742_abnormal_vestibular_system0.52890727
166MP0003690_abnormal_glial_cell0.52244749
167MP0010768_mortality/aging0.51252733
168MP0003956_abnormal_body_size0.50804060

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.79941392
2Myokymia (HP:0002411)7.48342609
3Focal seizures (HP:0007359)5.49456724
4Epileptic encephalopathy (HP:0200134)4.44515046
5Visual hallucinations (HP:0002367)4.43704456
6Febrile seizures (HP:0002373)4.42797657
7Atonic seizures (HP:0010819)4.37089017
8Pancreatic cysts (HP:0001737)4.04655543
9Impaired vibration sensation in the lower limbs (HP:0002166)4.02294764
10Absence seizures (HP:0002121)3.88561119
11True hermaphroditism (HP:0010459)3.88084993
12Ankle clonus (HP:0011448)3.70283558
13Generalized tonic-clonic seizures (HP:0002069)3.64204532
14Progressive cerebellar ataxia (HP:0002073)3.62183778
15Pancreatic fibrosis (HP:0100732)3.57555429
16Dialeptic seizures (HP:0011146)3.44792097
17Broad-based gait (HP:0002136)3.42049664
18Abnormal social behavior (HP:0012433)3.41777946
19Impaired social interactions (HP:0000735)3.41777946
20Poor eye contact (HP:0000817)3.36547155
21Urinary bladder sphincter dysfunction (HP:0002839)3.31399622
22Action tremor (HP:0002345)3.26857839
23Hyperventilation (HP:0002883)3.26295956
24Absent/shortened dynein arms (HP:0200106)3.13055093
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.13055093
26Abnormal eating behavior (HP:0100738)3.12261613
27Dysdiadochokinesis (HP:0002075)3.08287134
28Resting tremor (HP:0002322)3.05471490
29Torticollis (HP:0000473)3.03729475
30Esophageal atresia (HP:0002032)3.00453186
31Gaze-evoked nystagmus (HP:0000640)2.99025181
32Abnormal ciliary motility (HP:0012262)2.98995660
33Mutism (HP:0002300)2.97568133
34Stomach cancer (HP:0012126)2.92807284
35Progressive inability to walk (HP:0002505)2.90467968
36Depression (HP:0000716)2.88919757
37Optic neuritis (HP:0100653)2.84713775
38Retrobulbar optic neuritis (HP:0100654)2.84713775
39Dysmetria (HP:0001310)2.82743398
40Fetal akinesia sequence (HP:0001989)2.81920282
41Polyphagia (HP:0002591)2.81532642
42Urinary urgency (HP:0000012)2.80125531
43Abnormality of the lower motor neuron (HP:0002366)2.79507574
44Truncal ataxia (HP:0002078)2.79164158
45Anxiety (HP:0000739)2.78722437
46Orchitis (HP:0100796)2.78371641
47Nephronophthisis (HP:0000090)2.77589437
48Molar tooth sign on MRI (HP:0002419)2.74639893
49Abnormality of midbrain morphology (HP:0002418)2.74639893
50Abnormality of the renal medulla (HP:0100957)2.74117599
51Type II lissencephaly (HP:0007260)2.72739767
52Papilledema (HP:0001085)2.71215947
53Focal dystonia (HP:0004373)2.69906722
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69126519
55Short 4th metacarpal (HP:0010044)2.69126519
56Spastic gait (HP:0002064)2.68079703
57Abnormality of binocular vision (HP:0011514)2.66593956
58Diplopia (HP:0000651)2.66593956
59Impaired vibratory sensation (HP:0002495)2.66355631
60Gait imbalance (HP:0002141)2.65334341
61Pheochromocytoma (HP:0002666)2.63748465
62Supranuclear gaze palsy (HP:0000605)2.60300662
63Epileptiform EEG discharges (HP:0011182)2.59269611
64Cystic liver disease (HP:0006706)2.59066815
65EEG with generalized epileptiform discharges (HP:0011198)2.57099855
66Abnormality of the corticospinal tract (HP:0002492)2.56418378
67Hypsarrhythmia (HP:0002521)2.54977372
68Postural instability (HP:0002172)2.54592913
69Drooling (HP:0002307)2.53762341
70Excessive salivation (HP:0003781)2.53762341
71Craniofacial dystonia (HP:0012179)2.51625434
72Abnormal respiratory epithelium morphology (HP:0012253)2.51255703
73Abnormal respiratory motile cilium morphology (HP:0005938)2.51255703
74Pendular nystagmus (HP:0012043)2.49917793
75Congenital stationary night blindness (HP:0007642)2.49366295
76Limb dystonia (HP:0002451)2.48462342
77Termporal pattern (HP:0011008)2.48029811
78Insidious onset (HP:0003587)2.48029811
79Scanning speech (HP:0002168)2.47574269
80Abnormal respiratory motile cilium physiology (HP:0012261)2.47369598
81Genetic anticipation (HP:0003743)2.46585339
82Myositis (HP:0100614)2.46326882
83Gastrointestinal atresia (HP:0002589)2.43349466
84Amyotrophic lateral sclerosis (HP:0007354)2.42372462
85Abnormality of the labia minora (HP:0012880)2.41575318
86Annular pancreas (HP:0001734)2.40818461
87Chronic hepatic failure (HP:0100626)2.36110632
88Aqueductal stenosis (HP:0002410)2.35925318
89Stomatitis (HP:0010280)2.35659681
90Anophthalmia (HP:0000528)2.35644860
91Akinesia (HP:0002304)2.35364829
92Abnormality of the renal cortex (HP:0011035)2.29362764
93Neuronal loss in central nervous system (HP:0002529)2.26387565
94Attenuation of retinal blood vessels (HP:0007843)2.25554651
95Stereotypic behavior (HP:0000733)2.24855958
96Bradykinesia (HP:0002067)2.24290991
97Inability to walk (HP:0002540)2.24180411
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22571792
99Neuroendocrine neoplasm (HP:0100634)2.21722427
100Poor suck (HP:0002033)2.21456509
101Specific learning disability (HP:0001328)2.21295885
102Dysmetric saccades (HP:0000641)2.19858232
103Amblyopia (HP:0000646)2.19464844
104Lower limb muscle weakness (HP:0007340)2.16363328
105Hypoplastic labia majora (HP:0000059)2.16108217
106Decreased central vision (HP:0007663)2.15260919
107Protruding tongue (HP:0010808)2.14422934
108Subacute progressive viral hepatitis (HP:0006572)2.13640430
109Generalized myoclonic seizures (HP:0002123)2.13593402
110Anencephaly (HP:0002323)2.12819038
111Impaired smooth pursuit (HP:0007772)2.12433054
112Hemiplegia (HP:0002301)2.11357577
113Sclerocornea (HP:0000647)2.10841573
114Widely spaced teeth (HP:0000687)2.10768544
115Aplasia/Hypoplasia of the tongue (HP:0010295)2.09705459
116Keratoconjunctivitis (HP:0001096)2.09363927
117Congenital primary aphakia (HP:0007707)2.09069469
118Abnormality of incisor morphology (HP:0011063)2.09067053
119Arthropathy (HP:0003040)2.08231802
120Pointed chin (HP:0000307)2.07192685
121Hemiparesis (HP:0001269)2.04274141
122Furrowed tongue (HP:0000221)2.03875202
123Clonus (HP:0002169)2.03098716
124Optic nerve hypoplasia (HP:0000609)2.02646993
125Oligodactyly (hands) (HP:0001180)2.02583890
126Fair hair (HP:0002286)2.02240007
127Status epilepticus (HP:0002133)2.00926722
128Keratoconjunctivitis sicca (HP:0001097)2.00748765
129Absent speech (HP:0001344)2.00032474
130Congenital hepatic fibrosis (HP:0002612)1.98566546
131Tubular atrophy (HP:0000092)1.98246141
132Failure to thrive in infancy (HP:0001531)1.97643827
133Cupped ear (HP:0000378)1.97135793
134Lissencephaly (HP:0001339)1.96419564
135Nephrogenic diabetes insipidus (HP:0009806)1.96307287
136Lower limb amyotrophy (HP:0007210)1.95496386
137Intention tremor (HP:0002080)1.94697836
138Abnormality of ocular smooth pursuit (HP:0000617)1.94345419
139Cerebellar dysplasia (HP:0007033)1.94206388
140Impaired pain sensation (HP:0007328)1.93339773
141Abnormality of pain sensation (HP:0010832)1.93339773
142Ankyloglossia (HP:0010296)1.93306047
143Postaxial foot polydactyly (HP:0001830)1.91844108
144Abnormality of the 4th metacarpal (HP:0010012)1.89628750
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88949024
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87971657
147Vitreoretinal degeneration (HP:0000655)1.87360298
148Abnormal hair whorl (HP:0010721)1.86120319
149Abnormality of saccadic eye movements (HP:0000570)1.85840823
150Sleep apnea (HP:0010535)1.84601250
151Abnormality of the labia majora (HP:0012881)1.84530050
152Ventricular fibrillation (HP:0001663)1.84500501
153Preaxial hand polydactyly (HP:0001177)1.83483280
154Amelogenesis imperfecta (HP:0000705)1.83336562
155Microtia (HP:0008551)1.83334255
156Sacral dimple (HP:0000960)1.82114362
157Incomplete penetrance (HP:0003829)1.82101837
158Generalized hypotonia (HP:0001290)1.81886766
159Medial flaring of the eyebrow (HP:0010747)1.81836253
160Generalized hypopigmentation of hair (HP:0011358)1.81782368
161Neoplasm of the peripheral nervous system (HP:0100007)1.80677986
162Blue irides (HP:0000635)1.79953364
163Septo-optic dysplasia (HP:0100842)1.79827171
164Genital tract atresia (HP:0001827)1.79724213
165Vaginal atresia (HP:0000148)1.79165499
166Inappropriate behavior (HP:0000719)1.78786469
167Hematochezia (HP:0002573)1.78533728
168Colon cancer (HP:0003003)1.78511937
169Gait ataxia (HP:0002066)1.78462037
170Hypoplastic iliac wings (HP:0002866)1.78444847
171Increased corneal curvature (HP:0100692)1.78186513
172Keratoconus (HP:0000563)1.78186513
173Intestinal atresia (HP:0011100)1.75781997
174Occipital encephalocele (HP:0002085)1.75356286
175Long nose (HP:0003189)1.74104598
176Chorioretinal atrophy (HP:0000533)1.72498604
177Birth length less than 3rd percentile (HP:0003561)1.69725730
178Abnormality of alanine metabolism (HP:0010916)1.68922444
179Hyperalaninemia (HP:0003348)1.68922444
180Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68922444
181Preaxial foot polydactyly (HP:0001841)1.68810921
182Recurrent bacterial skin infections (HP:0005406)1.67721366
183Tracheomalacia (HP:0002779)1.67489081
184Spontaneous hematomas (HP:0007420)1.67114654
185Disproportionate short-trunk short stature (HP:0003521)1.66373400
186Aplasia of the phalanges of the hand (HP:0009802)1.65942632
187Aplasia involving bones of the extremities (HP:0009825)1.65942632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.74168962
2NTRK34.23447374
3EPHA44.21727679
4MAP3K94.11226892
5MARK14.06069746
6MAP3K43.31325172
7STK38L3.00446896
8LATS12.84191105
9MAP2K72.79199329
10MINK12.74829513
11IRAK42.44399936
12NTRK22.42368032
13KSR22.36144826
14ACVR1B2.35971210
15BMPR1B2.29092330
16DAPK22.27621311
17INSRR2.23799243
18MAP3K122.12266126
19IRAK12.03053472
20CASK2.02784619
21MAP2K41.95425570
22NTRK11.90380142
23PAK61.88980310
24TIE11.87057908
25PTK2B1.83648386
26KSR11.80723413
27MAPK131.67200460
28ADRBK21.64985808
29DAPK11.56021106
30CDK51.55359909
31IRAK21.54635271
32PINK11.54424272
33CAMKK11.53889559
34YES11.51230221
35TAOK11.49750616
36LATS21.49514710
37PRKD31.49403540
38EPHB11.48660009
39FGFR21.46627960
40WNK11.38489236
41ZAK1.37973486
42FES1.28352477
43PRPF4B1.27656605
44PLK21.27484996
45FGR1.26074104
46TNIK1.25114902
47NUAK11.24647758
48ARAF1.23967313
49MAP3K21.22380248
50PDK41.21650406
51PDK31.21650406
52TGFBR11.20108194
53ADRBK11.19909668
54PRKCG1.19647061
55NLK1.17794780
56CSK1.16367883
57NEK11.13760584
58SIK21.12937017
59BLK1.11483336
60EPHB21.09260423
61GRK51.07416042
62SGK21.07320984
63MET1.05960285
64BRSK21.05163006
65PHKG11.04923694
66PHKG21.04923694
67DYRK31.04221499
68STK381.03547332
69SGK2231.03179267
70SGK4941.03179267
71ERBB41.03170274
72STK31.02851453
73MAP3K131.02249484
74GRK11.01982311
75AKT30.97901707
76TYRO30.95686222
77RIPK40.94883237
78CDK180.93610328
79CAMK2A0.91579893
80CDK150.88440485
81NEK90.87962862
82EPHA30.87779994
83RAF10.87708270
84CDK140.85115153
85UHMK10.84473452
86PTK60.82991165
87PRKCH0.82657582
88WNK40.82575754
89MKNK20.81814302
90SGK30.79519891
91PAK30.78140048
92MAP3K70.77337032
93MARK20.76451722
94LMTK20.75074912
95CDK11A0.74882808
96BRAF0.74874786
97EPHA20.74148700
98ERBB20.73935886
99TAOK30.73384417
100MAP3K60.73248677
101RET0.70317034
102SGK10.68478366
103TEC0.68416069
104MAP2K30.67716645
105ALK0.67337147
106STK110.66534765
107HCK0.66434906
108PRKAA20.64283566
109RPS6KA20.62792115
110PIK3CG0.60885526
111BTK0.60388442
112MST1R0.60283102
113CSNK1A1L0.59762791
114MELK0.59345367
115MUSK0.58937768
116MAP4K20.58721823
117TNK20.58307814
118CSNK1G20.58249148
119TSSK60.57078484
120CDK190.56731518
121CCNB10.55730593
122CAMKK20.55035267
123ITK0.54265758
124SCYL20.53840242
125TRIM280.53452729
126MAP2K10.52194357
127RPS6KA30.51924714
128PDK20.51522241
129DYRK1A0.51381127
130CDK80.50834076
131CAMK2B0.50832183
132JAK30.50756753
133SIK30.50670276
134PRKCZ0.50515055
135PNCK0.49596733
136CSNK1G10.49171569
137PRKCE0.47642140
138CAMK10.47441044
139STK390.46250870
140DYRK20.45950676
141BMPR20.45470706
142TGFBR20.45312612
143PDK10.44270179
144TXK0.44136562
145WNK30.43831441
146MAPK100.42445575
147STK240.41851257
148FER0.41692685
149BCR0.41371589
150PDPK10.40223678
151CAMK40.39812195
152LYN0.38964353
153JAK20.38202368
154MKNK10.38191965
155BRSK10.37823086
156FYN0.36535350
157ERBB30.35530074
158MAP3K10.35332463
159PRKCB0.33064235
160ROCK10.32838851
161DAPK30.31955169
162OXSR10.30479348
163NEK60.28254010
164PRKACA0.27972536

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.69956931
2Nicotine addiction_Homo sapiens_hsa050333.59877660
3Olfactory transduction_Homo sapiens_hsa047403.15821477
4GABAergic synapse_Homo sapiens_hsa047272.92450854
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70589687
6Morphine addiction_Homo sapiens_hsa050322.70574224
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.63290299
8Circadian entrainment_Homo sapiens_hsa047132.62809538
9Glutamatergic synapse_Homo sapiens_hsa047242.48508408
10Long-term potentiation_Homo sapiens_hsa047202.38692761
11Amphetamine addiction_Homo sapiens_hsa050312.35826512
12Dopaminergic synapse_Homo sapiens_hsa047282.31016528
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22797652
14Collecting duct acid secretion_Homo sapiens_hsa049662.17605811
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.12705030
16Linoleic acid metabolism_Homo sapiens_hsa005912.05579362
17Cholinergic synapse_Homo sapiens_hsa047252.00343215
18Cocaine addiction_Homo sapiens_hsa050301.96735723
19Salivary secretion_Homo sapiens_hsa049701.88334369
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84868511
21Hedgehog signaling pathway_Homo sapiens_hsa043401.82165990
22Serotonergic synapse_Homo sapiens_hsa047261.79379418
23Insulin secretion_Homo sapiens_hsa049111.78273466
24Ether lipid metabolism_Homo sapiens_hsa005651.77331035
25Taste transduction_Homo sapiens_hsa047421.69406863
26Long-term depression_Homo sapiens_hsa047301.69334975
27Basal cell carcinoma_Homo sapiens_hsa052171.68960587
28Gastric acid secretion_Homo sapiens_hsa049711.62831642
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62753918
30Renin secretion_Homo sapiens_hsa049241.60137019
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59029142
32Oxytocin signaling pathway_Homo sapiens_hsa049211.57438059
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48298327
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44143777
35Gap junction_Homo sapiens_hsa045401.43338588
36Calcium signaling pathway_Homo sapiens_hsa040201.42123343
37GnRH signaling pathway_Homo sapiens_hsa049121.41587705
38Regulation of autophagy_Homo sapiens_hsa041401.37613442
39Vibrio cholerae infection_Homo sapiens_hsa051101.33563237
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31197730
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27653870
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26952385
43Fatty acid biosynthesis_Homo sapiens_hsa000611.24660359
44ABC transporters_Homo sapiens_hsa020101.23172059
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22391856
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22061557
47Fanconi anemia pathway_Homo sapiens_hsa034601.21851814
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21720055
49cAMP signaling pathway_Homo sapiens_hsa040241.13620095
50Axon guidance_Homo sapiens_hsa043601.12872778
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12769945
52Basal transcription factors_Homo sapiens_hsa030221.12543713
53Estrogen signaling pathway_Homo sapiens_hsa049151.12429328
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11255294
55ErbB signaling pathway_Homo sapiens_hsa040121.08695797
56Glioma_Homo sapiens_hsa052141.07007184
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04901983
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04724942
59Oocyte meiosis_Homo sapiens_hsa041141.03788929
60Type II diabetes mellitus_Homo sapiens_hsa049301.03707318
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03397130
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03051769
63Arachidonic acid metabolism_Homo sapiens_hsa005901.02822874
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00796534
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00598203
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99687858
67Histidine metabolism_Homo sapiens_hsa003400.98024145
68Selenocompound metabolism_Homo sapiens_hsa004500.97388895
69Hippo signaling pathway_Homo sapiens_hsa043900.97153333
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95981721
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93193294
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90672200
73Melanogenesis_Homo sapiens_hsa049160.89567680
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89073288
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.87643941
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87452301
77Homologous recombination_Homo sapiens_hsa034400.85279131
78Wnt signaling pathway_Homo sapiens_hsa043100.85005718
79Type I diabetes mellitus_Homo sapiens_hsa049400.84635610
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81958391
81FoxO signaling pathway_Homo sapiens_hsa040680.80416945
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.79296485
83Cardiac muscle contraction_Homo sapiens_hsa042600.76859363
84Alcoholism_Homo sapiens_hsa050340.76420070
85Osteoclast differentiation_Homo sapiens_hsa043800.74296343
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.74045662
87Glycerolipid metabolism_Homo sapiens_hsa005610.73601681
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73526805
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73313987
90Tuberculosis_Homo sapiens_hsa051520.72005548
91Dorso-ventral axis formation_Homo sapiens_hsa043200.71507056
92MAPK signaling pathway_Homo sapiens_hsa040100.70227155
93Dilated cardiomyopathy_Homo sapiens_hsa054140.69320088
94ECM-receptor interaction_Homo sapiens_hsa045120.69033906
95Tryptophan metabolism_Homo sapiens_hsa003800.68387318
96Pathways in cancer_Homo sapiens_hsa052000.68146115
97Phototransduction_Homo sapiens_hsa047440.67466362
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65931662
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65854366
100Choline metabolism in cancer_Homo sapiens_hsa052310.65320481
101Ovarian steroidogenesis_Homo sapiens_hsa049130.64832739
102Ras signaling pathway_Homo sapiens_hsa040140.64651787
103Endometrial cancer_Homo sapiens_hsa052130.64449348
104beta-Alanine metabolism_Homo sapiens_hsa004100.63531217
105Thyroid hormone synthesis_Homo sapiens_hsa049180.62832752
106Malaria_Homo sapiens_hsa051440.62200371
107Adherens junction_Homo sapiens_hsa045200.60591613
108Platelet activation_Homo sapiens_hsa046110.60457616
109Rap1 signaling pathway_Homo sapiens_hsa040150.59084101
110p53 signaling pathway_Homo sapiens_hsa041150.59077594
111Notch signaling pathway_Homo sapiens_hsa043300.58108323
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58022671
113Butanoate metabolism_Homo sapiens_hsa006500.56478113
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.56279817
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56090904
116Glucagon signaling pathway_Homo sapiens_hsa049220.55244220
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.54122792
118African trypanosomiasis_Homo sapiens_hsa051430.53946350
119Small cell lung cancer_Homo sapiens_hsa052220.53343076
120Non-small cell lung cancer_Homo sapiens_hsa052230.53034211
121Renal cell carcinoma_Homo sapiens_hsa052110.51529663
122Colorectal cancer_Homo sapiens_hsa052100.50330373
123Pancreatic secretion_Homo sapiens_hsa049720.50197698
124TGF-beta signaling pathway_Homo sapiens_hsa043500.49952451
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49737790
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.49727473
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48865453
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48067242
129mTOR signaling pathway_Homo sapiens_hsa041500.47964337
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46806644
131Leishmaniasis_Homo sapiens_hsa051400.46539149
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.46392039
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46122275
134VEGF signaling pathway_Homo sapiens_hsa043700.45433401
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44568258
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43416934
137Insulin signaling pathway_Homo sapiens_hsa049100.42227798
138TNF signaling pathway_Homo sapiens_hsa046680.40904735
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40191329
140Endocytosis_Homo sapiens_hsa041440.39350880
141Prion diseases_Homo sapiens_hsa050200.39001458
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38455081
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37915888
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.37697574
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37404759
146Nitrogen metabolism_Homo sapiens_hsa009100.37071467
147Rheumatoid arthritis_Homo sapiens_hsa053230.36339460
148Bile secretion_Homo sapiens_hsa049760.36146081
149Circadian rhythm_Homo sapiens_hsa047100.32409901
150Inositol phosphate metabolism_Homo sapiens_hsa005620.31639046
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30353776
152Oxidative phosphorylation_Homo sapiens_hsa001900.29944662
153Chemokine signaling pathway_Homo sapiens_hsa040620.28994186
154Parkinsons disease_Homo sapiens_hsa050120.28679369
155Tight junction_Homo sapiens_hsa045300.28272862
156Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27556636

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