ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	4.13229532
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.97935742
3	behavioral response to nicotine (GO:0035095)	3.66219250
4	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.61285259
5	neural tube formation (GO:0001841)	3.57607848
6	regulation of hippo signaling (GO:0035330)	3.56204777
7	cilium movement (GO:0003341)	3.46754683
8	neuronal action potential propagation (GO:0019227)	3.40272500
9	pyrimidine nucleobase catabolic process (GO:0006208)	3.39140787
10	central nervous system projection neuron axonogenesis (GO:0021952)	3.34239096
11	indolalkylamine metabolic process (GO:0006586)	3.33381179
12	presynaptic membrane assembly (GO:0097105)	3.32079123
13	central nervous system neuron axonogenesis (GO:0021955)	3.31932421
14	tachykinin receptor signaling pathway (GO:0007217)	3.31691735
15	interkinetic nuclear migration (GO:0022027)	3.24277119
16	reflex (GO:0060004)	3.23646677
17	limb bud formation (GO:0060174)	3.23043727
18	indolalkylamine catabolic process (GO:0046218)	3.20887231
19	tryptophan catabolic process (GO:0006569)	3.20887231
20	indole-containing compound catabolic process (GO:0042436)	3.20887231
21	gamma-aminobutyric acid transport (GO:0015812)	3.16896362
22	epithelial cilium movement (GO:0003351)	3.11524359
23	kynurenine metabolic process (GO:0070189)	3.10501906
24	cerebral cortex radially oriented cell migration (GO:0021799)	3.04656575
25	limb development (GO:0060173)	2.97999892
26	appendage development (GO:0048736)	2.97999892
27	photoreceptor cell maintenance (GO:0045494)	2.96860622
28	cilium organization (GO:0044782)	2.95423380
29	inner ear receptor stereocilium organization (GO:0060122)	2.94851382
30	serotonin metabolic process (GO:0042428)	2.94704334
31	behavioral response to ethanol (GO:0048149)	2.93854431
32	regulation of sarcomere organization (GO:0060297)	2.92836948
33	response to pheromone (GO:0019236)	2.92692808
34	cilium assembly (GO:0042384)	2.92035553
35	retinal ganglion cell axon guidance (GO:0031290)	2.91143937
36	nucleus localization (GO:0051647)	2.90623091
37	detection of light stimulus involved in visual perception (GO:0050908)	2.88211762
38	detection of light stimulus involved in sensory perception (GO:0050962)	2.88211762
39	atrial cardiac muscle cell action potential (GO:0086014)	2.86117140
40	fucose catabolic process (GO:0019317)	2.84901254
41	L-fucose metabolic process (GO:0042354)	2.84901254
42	L-fucose catabolic process (GO:0042355)	2.84901254
43	positive regulation of action potential (GO:0045760)	2.84889493
44	cAMP catabolic process (GO:0006198)	2.84282631
45	signal peptide processing (GO:0006465)	2.83982995
46	cilium morphogenesis (GO:0060271)	2.80018709
47	postsynaptic membrane organization (GO:0001941)	2.78013369
48	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.77170180
49	presynaptic membrane organization (GO:0097090)	2.77102225
50	nucleobase catabolic process (GO:0046113)	2.74966602
51	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.74018711
52	regulation of translation, ncRNA-mediated (GO:0045974)	2.74018711
53	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.74018711
54	indole-containing compound metabolic process (GO:0042430)	2.73234729
55	negative regulation of astrocyte differentiation (GO:0048712)	2.70008537
56	primary amino compound metabolic process (GO:1901160)	2.69569862
57	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.68326236
58	tryptophan metabolic process (GO:0006568)	2.67354248
59	nonmotile primary cilium assembly (GO:0035058)	2.65828000
60	intraciliary transport (GO:0042073)	2.59535643
61	axoneme assembly (GO:0035082)	2.58068067
62	motile cilium assembly (GO:0044458)	2.57494404
63	cellular response to sterol (GO:0036315)	2.57000973
64	somite development (GO:0061053)	2.55459130
65	establishment of protein localization to Golgi (GO:0072600)	2.55120041
66	cyclic nucleotide catabolic process (GO:0009214)	2.54188130
67	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.53749091
68	retinal cone cell development (GO:0046549)	2.53601207
69	cellular component assembly involved in morphogenesis (GO:0010927)	2.53247274
70	regulation of action potential (GO:0098900)	2.52656948
71	cerebral cortex cell migration (GO:0021795)	2.49794806
72	glycosphingolipid biosynthetic process (GO:0006688)	2.48690437
73	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.48513317
74	transmission of nerve impulse (GO:0019226)	2.48056086
75	smoothened signaling pathway (GO:0007224)	2.47497514
76	regulation of pigment cell differentiation (GO:0050932)	2.45609309
77	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.45166629
78	regulation of neuron projection regeneration (GO:0070570)	2.44559588
79	regulation of axon regeneration (GO:0048679)	2.44559588
80	vocalization behavior (GO:0071625)	2.44135405
81	negative chemotaxis (GO:0050919)	2.44095062
82	startle response (GO:0001964)	2.44077469
83	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.42545706
84	regulation of axon guidance (GO:1902667)	2.38902116
85	axonemal dynein complex assembly (GO:0070286)	2.38679806
86	membrane depolarization during action potential (GO:0086010)	2.38394443
87	regulation of collateral sprouting (GO:0048670)	2.37244288
88	negative regulation of Rho protein signal transduction (GO:0035024)	2.36514921
89	smooth muscle contraction (GO:0006939)	2.36443867
90	cornea development in camera-type eye (GO:0061303)	2.35861230
91	lateral sprouting from an epithelium (GO:0060601)	2.32341578
92	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.30868251
93	neuronal action potential (GO:0019228)	2.27539095
94	regulation of axon extension involved in axon guidance (GO:0048841)	2.25773483
95	regulation of cilium movement (GO:0003352)	2.24603245
96	protein localization to cilium (GO:0061512)	2.24379086
97	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.24106229
98	righting reflex (GO:0060013)	2.23637373
99	establishment of nucleus localization (GO:0040023)	2.23414315
100	cell proliferation in forebrain (GO:0021846)	2.21937197

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.64811623
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.44211745
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.06300617
4	VDR_22108803_ChIP-Seq_LS180_Human	2.78749878
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77131908
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.73849836
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56973457
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.51346283
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.43851164
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31027036
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.27199283
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.24473299
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.18639953
14	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.17218146
15	FUS_26573619_Chip-Seq_HEK293_Human	2.15137538
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.10756730
17	P300_19829295_ChIP-Seq_ESCs_Human	2.08386398
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.04752601
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01419389
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.93436019
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.93104142
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.91564791
23	EWS_26573619_Chip-Seq_HEK293_Human	1.87725537
24	STAT3_23295773_ChIP-Seq_U87_Human	1.81906711
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.78063296
26	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.74402579
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72581488
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.66462483
29	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.66449033
30	TP53_16413492_ChIP-PET_HCT116_Human	1.65662224
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.63386090
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63015468
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63015468
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62890426
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62748728
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62662805
37	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.62128758
38	TCF4_23295773_ChIP-Seq_U87_Human	1.61968670
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.61225830
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.61064935
41	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.58469525
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.54894295
43	AR_25329375_ChIP-Seq_VCAP_Human	1.51944256
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48553214
45	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.45122731
46	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.42676815
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41471264
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.41471264
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.39820664
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36558319
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.36015940
52	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.35436219
53	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.34658124
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33239531
55	AHR_22903824_ChIP-Seq_MCF-7_Human	1.31356363
56	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.31278983
57	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.31278983
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.30078566
59	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29760604
60	CJUN_26792858_Chip-Seq_BT549_Human	1.29666475
61	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29102883
62	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.26675535
63	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26337053
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25208527
65	DROSHA_22980978_ChIP-Seq_HELA_Human	1.25023820
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24412983
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.23756274
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22977054
69	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.20990022
70	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19696173
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19224411
72	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.18547903
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18363067
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18219276
75	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17442788
76	TP53_18474530_ChIP-ChIP_U2OS_Human	1.17303285
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16828819
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16737680
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16264243
80	KDM2B_26808549_Chip-Seq_REH_Human	1.15478064
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14389070
82	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.13922153
83	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10603497
84	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.10014446
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.09972459
86	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09759962
87	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.09697270
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09499163
89	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.08922639
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08512314
91	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08051920
92	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.07379967
93	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.06990014
94	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06774988
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06391773
96	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.06316330
97	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06160043
98	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03984466
99	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.03017536
100	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.02389142

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.15200599
2	MP0003136_yellow_coat_color	2.43283523
3	MP0003880_abnormal_central_pattern	2.18132431
4	MP0000566_synostosis	2.16516760
5	MP0001968_abnormal_touch/_nociception	2.11893652
6	MP0002102_abnormal_ear_morphology	2.08803218
7	MP0010386_abnormal_urinary_bladder	2.03468806
8	MP0005551_abnormal_eye_electrophysiolog	2.00044573
9	MP0000778_abnormal_nervous_system	1.93820010
10	MP0004215_abnormal_myocardial_fiber	1.92782432
11	MP0000427_abnormal_hair_cycle	1.92380208
12	MP0002736_abnormal_nociception_after	1.92169036
13	MP0001486_abnormal_startle_reflex	1.91289917
14	MP0006292_abnormal_olfactory_placode	1.89966583
15	MP0009046_muscle_twitch	1.87756052
16	MP0001984_abnormal_olfaction	1.82708898
17	MP0005167_abnormal_blood-brain_barrier	1.71005359
18	MP0009745_abnormal_behavioral_response	1.69107971
19	MP0001501_abnormal_sleep_pattern	1.69035780
20	MP0003195_calcinosis	1.67480357
21	MP0006276_abnormal_autonomic_nervous	1.65268857
22	MP0000383_abnormal_hair_follicle	1.64674408
23	MP0002938_white_spotting	1.61076787
24	MP0003950_abnormal_plasma_membrane	1.59635566
25	MP0002735_abnormal_chemical_nociception	1.53311742
26	MP0005386_behavior/neurological_phenoty	1.51442220
27	MP0004924_abnormal_behavior	1.51442220
28	MP0004145_abnormal_muscle_electrophysio	1.51303953
29	MP0005171_absent_coat_pigmentation	1.51142962
30	MP0005187_abnormal_penis_morphology	1.46844951
31	MP0005248_abnormal_Harderian_gland	1.44644461
32	MP0004043_abnormal_pH_regulation	1.44360870
33	MP0002572_abnormal_emotion/affect_behav	1.41263373
34	MP0004133_heterotaxia	1.40260287
35	MP0003635_abnormal_synaptic_transmissio	1.39752375
36	MP0004885_abnormal_endolymph	1.39511665
37	MP0005253_abnormal_eye_physiology	1.39490957
38	MP0003937_abnormal_limbs/digits/tail_de	1.39484268
39	MP0000631_abnormal_neuroendocrine_gland	1.38606403
40	MP0005174_abnormal_tail_pigmentation	1.36913106
41	MP0000049_abnormal_middle_ear	1.35116436
42	MP0002272_abnormal_nervous_system	1.34970224
43	MP0001879_abnormal_lymphatic_vessel	1.31243115
44	MP0002234_abnormal_pharynx_morphology	1.25285922
45	MP0010368_abnormal_lymphatic_system	1.25038843
46	MP0001293_anophthalmia	1.24458523
47	MP0002233_abnormal_nose_morphology	1.23309424
48	MP0002067_abnormal_sensory_capabilities	1.23135016
49	MP0002063_abnormal_learning/memory/cond	1.22387991
50	MP0004142_abnormal_muscle_tone	1.21556741
51	MP0004859_abnormal_synaptic_plasticity	1.20762183
52	MP0002064_seizures	1.16874127
53	MP0003890_abnormal_embryonic-extraembry	1.15700519
54	MP0010030_abnormal_orbit_morphology	1.14696775
55	MP0004484_altered_response_of	1.14056151
56	MP0003119_abnormal_digestive_system	1.14049220
57	MP0008877_abnormal_DNA_methylation	1.13035626
58	MP0002653_abnormal_ependyma_morphology	1.12917481
59	MP0005195_abnormal_posterior_eye	1.12437195
60	MP0003787_abnormal_imprinting	1.10082966
61	MP0005377_hearing/vestibular/ear_phenot	1.09770515
62	MP0003878_abnormal_ear_physiology	1.09770515
63	MP0002638_abnormal_pupillary_reflex	1.08326410
64	MP0002168_other_aberrant_phenotype	1.07679451
65	MP0005646_abnormal_pituitary_gland	1.07427493
66	MP0002184_abnormal_innervation	1.06289807
67	MP0009053_abnormal_anal_canal	1.06042625
68	MP0001440_abnormal_grooming_behavior	1.05623674
69	MP0008057_abnormal_DNA_replication	1.04435506
70	MP0002752_abnormal_somatic_nervous	1.03523875
71	MP0001485_abnormal_pinna_reflex	1.03132991
72	MP0001970_abnormal_pain_threshold	1.02974292
73	MP0000647_abnormal_sebaceous_gland	1.02797630
74	MP0000026_abnormal_inner_ear	1.00966158
75	MP0005670_abnormal_white_adipose	0.99984038
76	MP0002557_abnormal_social/conspecific_i	0.97915284
77	MP0008789_abnormal_olfactory_epithelium	0.97510533
78	MP0000428_abnormal_craniofacial_morphol	0.96557772
79	MP0003045_fibrosis	0.95026811
80	MP0001299_abnormal_eye_distance/	0.95023697
81	MP0010678_abnormal_skin_adnexa	0.94489905
82	MP0000955_abnormal_spinal_cord	0.93377270
83	MP0005391_vision/eye_phenotype	0.92656749
84	MP0002882_abnormal_neuron_morphology	0.92377376
85	MP0000230_abnormal_systemic_arterial	0.91436754
86	MP0003755_abnormal_palate_morphology	0.90184770
87	MP0003121_genomic_imprinting	0.89643848
88	MP0004085_abnormal_heartbeat	0.89267543
89	MP0005595_abnormal_vascular_smooth	0.87560940
90	MP0003646_muscle_fatigue	0.86399343
91	MP0003137_abnormal_impulse_conducting	0.86344102
92	MP0004272_abnormal_basement_membrane	0.86332735
93	MP0008872_abnormal_physiological_respon	0.84984438
94	MP0002282_abnormal_trachea_morphology	0.82666986
95	MP0002733_abnormal_thermal_nociception	0.82514641
96	MP0002734_abnormal_mechanical_nocicepti	0.81885162
97	MP0004130_abnormal_muscle_cell	0.81544005
98	MP0003252_abnormal_bile_duct	0.81074690
99	MP0002928_abnormal_bile_duct	0.80661561
100	MP0006072_abnormal_retinal_apoptosis	0.80522767

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.18987378
2	Pancreatic fibrosis (HP:0100732)	4.01947994
3	True hermaphroditism (HP:0010459)	4.01401685
4	Hyperventilation (HP:0002883)	3.84444101
5	Molar tooth sign on MRI (HP:0002419)	3.58156628
6	Abnormality of midbrain morphology (HP:0002418)	3.58156628
7	Nephronophthisis (HP:0000090)	3.47624158
8	Abnormality of the renal medulla (HP:0100957)	3.29599293
9	Gaze-evoked nystagmus (HP:0000640)	3.26363130
10	Abnormal ciliary motility (HP:0012262)	3.22958932
11	Cystic liver disease (HP:0006706)	3.05617938
12	Genetic anticipation (HP:0003743)	3.02374233
13	Absent/shortened dynein arms (HP:0200106)	2.99723951
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.99723951
15	Progressive cerebellar ataxia (HP:0002073)	2.94526033
16	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.83148788
17	Febrile seizures (HP:0002373)	2.74344723
18	Chronic hepatic failure (HP:0100626)	2.71747912
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.69757332
20	Focal seizures (HP:0007359)	2.67633395
21	Abnormal respiratory motile cilium physiology (HP:0012261)	2.66662849
22	Abnormality of the renal cortex (HP:0011035)	2.63894089
23	Congenital stationary night blindness (HP:0007642)	2.61514827
24	Fair hair (HP:0002286)	2.56174341
25	Focal motor seizures (HP:0011153)	2.52989849
26	Medial flaring of the eyebrow (HP:0010747)	2.51195384
27	Protruding tongue (HP:0010808)	2.44025927
28	Absent speech (HP:0001344)	2.43868205
29	Decreased central vision (HP:0007663)	2.41993109
30	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.41762877
31	Short 4th metacarpal (HP:0010044)	2.41762877
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.38498207
33	Abnormal respiratory epithelium morphology (HP:0012253)	2.38498207
34	Postaxial foot polydactyly (HP:0001830)	2.37565222
35	Keratoconus (HP:0000563)	2.37088960
36	Increased corneal curvature (HP:0100692)	2.37088960
37	Tubular atrophy (HP:0000092)	2.36875877
38	Genital tract atresia (HP:0001827)	2.34657228
39	Congenital hepatic fibrosis (HP:0002612)	2.34488783
40	Attenuation of retinal blood vessels (HP:0007843)	2.28817970
41	Sclerocornea (HP:0000647)	2.28729885
42	Preaxial foot polydactyly (HP:0001841)	2.28392427
43	Occipital encephalocele (HP:0002085)	2.27171744
44	Cutaneous finger syndactyly (HP:0010554)	2.22618573
45	Drooling (HP:0002307)	2.22492537
46	Vaginal atresia (HP:0000148)	2.21951873
47	Broad-based gait (HP:0002136)	2.20371243
48	Hypoplastic labia majora (HP:0000059)	2.15660561
49	Type II lissencephaly (HP:0007260)	2.13974997
50	Gait imbalance (HP:0002141)	2.12317110
51	Anencephaly (HP:0002323)	2.11167937
52	Chorioretinal atrophy (HP:0000533)	2.09945935
53	Generalized hypopigmentation of hair (HP:0011358)	2.09192792
54	Preaxial hand polydactyly (HP:0001177)	2.05841049
55	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.04621111
56	Cutaneous syndactyly (HP:0012725)	2.04590731
57	Optic nerve hypoplasia (HP:0000609)	2.03830903
58	Long nose (HP:0003189)	2.03470107
59	Inability to walk (HP:0002540)	2.00506941
60	Abnormality of the ischium (HP:0003174)	1.99654078
61	Excessive salivation (HP:0003781)	1.99575415
62	Congenital primary aphakia (HP:0007707)	1.99160128
63	Postaxial hand polydactyly (HP:0001162)	1.98857045
64	Widely spaced teeth (HP:0000687)	1.98137260
65	Progressive inability to walk (HP:0002505)	1.97667735
66	Clumsiness (HP:0002312)	1.96486159
67	Abnormality of the labia majora (HP:0012881)	1.92098712
68	Aplasia involving bones of the upper limbs (HP:0009823)	1.91962037
69	Aplasia of the phalanges of the hand (HP:0009802)	1.91962037
70	Aplasia involving bones of the extremities (HP:0009825)	1.91962037
71	Furrowed tongue (HP:0000221)	1.89873939
72	Hemiparesis (HP:0001269)	1.86790894
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84440098
74	Lissencephaly (HP:0001339)	1.84000378
75	Anophthalmia (HP:0000528)	1.82283297
76	Nephrogenic diabetes insipidus (HP:0009806)	1.82173580
77	Tracheomalacia (HP:0002779)	1.82046959
78	Narrow forehead (HP:0000341)	1.77487005
79	Tented upper lip vermilion (HP:0010804)	1.76692648
80	Cerebellar dysplasia (HP:0007033)	1.76428442
81	Hypoplastic ischia (HP:0003175)	1.75540748
82	Renal hypoplasia (HP:0000089)	1.74813669
83	Abnormality of the 4th metacarpal (HP:0010012)	1.74237131
84	Abnormality of the nasal septum (HP:0000419)	1.73507099
85	Blue irides (HP:0000635)	1.72673949
86	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.71956716
87	Short foot (HP:0001773)	1.71943796
88	Fibular hypoplasia (HP:0003038)	1.69861511
89	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.68286087
90	Hypoplastic iliac wings (HP:0002866)	1.68045294
91	Pendular nystagmus (HP:0012043)	1.67979192
92	Dyskinesia (HP:0100660)	1.67612968
93	Renal dysplasia (HP:0000110)	1.66630515
94	Supernumerary spleens (HP:0009799)	1.65493860
95	Short tibia (HP:0005736)	1.65323226
96	Polydipsia (HP:0001959)	1.65181964
97	Abnormal drinking behavior (HP:0030082)	1.65181964
98	Median cleft lip (HP:0000161)	1.64549394
99	Exotropia (HP:0000577)	1.64508366
100	Rhinitis (HP:0012384)	1.63622503

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.77156996
2	BMPR1B	3.18077793
3	ACVR1B	2.81410261
4	CASK	2.72684548
5	TIE1	2.24487678
6	EPHA4	2.23712780
7	TNIK	2.20721557
8	MAP3K4	2.08387068
9	WNK3	2.07085976
10	STK38L	2.06012882
11	NTRK3	1.98769313
12	MARK1	1.85741047
13	MAPK13	1.77275371
14	MKNK2	1.73077986
15	TGFBR1	1.70672299
16	ADRBK2	1.66408767
17	INSRR	1.54194720
18	NTRK2	1.49635875
19	MAP4K2	1.43686565
20	STK39	1.41924509
21	PTK2B	1.38519527
22	WNK4	1.38164267
23	DMPK	1.30848652
24	NUAK1	1.28235771
25	CAMKK2	1.26859741
26	PAK3	1.26841891
27	PINK1	1.25925788
28	OXSR1	1.23922778
29	PNCK	1.20801048
30	MAP2K7	1.19811159
31	EPHB2	1.19660924
32	LATS1	1.18180755
33	BRSK2	1.17945423
34	PRKCE	1.16594461
35	GRK1	1.13051305
36	ADRBK1	1.12944919
37	STK3	1.12446259
38	MKNK1	1.10819706
39	BCR	1.09500427
40	FGFR2	1.08089857
41	ERBB3	1.03911906
42	MET	0.96335384
43	MAP3K7	0.89089805
44	PLK2	0.87916421
45	PRKCG	0.84899950
46	STK24	0.84875226
47	PIK3CA	0.84299104
48	FER	0.83185994
49	WNK1	0.82768172
50	NLK	0.78094127
51	DAPK2	0.76429882
52	SGK2	0.75137666
53	STK11	0.72222071
54	MYLK	0.72010591
55	MAP2K4	0.71183080
56	CAMK2A	0.69942560
57	TRIM28	0.69372155
58	ZAK	0.68647098
59	CAMK1G	0.68228548
60	PRKAA2	0.65345990
61	CSNK1G2	0.65164001
62	PKN1	0.64819831
63	ERBB2	0.62912637
64	IRAK1	0.62287987
65	FGFR1	0.60549947
66	PIK3CG	0.59041866
67	STK38	0.56691695
68	AKT3	0.55731294
69	ROCK1	0.55659398
70	TGFBR2	0.54832780
71	MELK	0.53295609
72	WEE1	0.53166549
73	CAMK1	0.52654835
74	CAMK1D	0.52325043
75	DYRK2	0.50623882
76	CSNK1A1L	0.47733779
77	DYRK1A	0.46945672
78	CAMK4	0.46230853
79	CSNK1D	0.46029650
80	TLK1	0.45653990
81	NTRK1	0.45405239
82	CSNK1G1	0.45404896
83	TAOK3	0.44033994
84	TRPM7	0.43682489
85	EPHA3	0.43081479
86	CDK3	0.40924792
87	DYRK3	0.40900811
88	KSR1	0.40101443
89	PRKAA1	0.38287057
90	MAP2K1	0.37798677
91	CDK5	0.37362408
92	PHKG1	0.36712228
93	PHKG2	0.36712228
94	SGK494	0.36644829
95	SGK223	0.36644829
96	PAK6	0.35165252
97	PRKACA	0.33982636
98	MAPK7	0.32416330
99	MAPK15	0.31219783
100	MAPKAPK5	0.30516782

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.85418415
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.09762015
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.06201181
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.04026567
5	Phototransduction_Homo sapiens_hsa04744	1.98170686
6	Taste transduction_Homo sapiens_hsa04742	1.93831991
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.93522701
8	Morphine addiction_Homo sapiens_hsa05032	1.90538462
9	Glutamatergic synapse_Homo sapiens_hsa04724	1.87914897
10	Circadian entrainment_Homo sapiens_hsa04713	1.80334287
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.78189582
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.77997825
13	Olfactory transduction_Homo sapiens_hsa04740	1.76341463
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73523706
15	Butanoate metabolism_Homo sapiens_hsa00650	1.70016762
16	ABC transporters_Homo sapiens_hsa02010	1.68280641
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.63059087
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58298346
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57445337
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.54883051
21	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.54770964
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.51376340
23	Serotonergic synapse_Homo sapiens_hsa04726	1.50800027
24	Histidine metabolism_Homo sapiens_hsa00340	1.49382047
25	Circadian rhythm_Homo sapiens_hsa04710	1.44590301
26	Axon guidance_Homo sapiens_hsa04360	1.43228386
27	GABAergic synapse_Homo sapiens_hsa04727	1.42389197
28	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.39139499
29	Basal cell carcinoma_Homo sapiens_hsa05217	1.37389481
30	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.35596330
31	Salivary secretion_Homo sapiens_hsa04970	1.33164177
32	Long-term depression_Homo sapiens_hsa04730	1.27602920
33	ECM-receptor interaction_Homo sapiens_hsa04512	1.25293087
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.21049417
35	Dopaminergic synapse_Homo sapiens_hsa04728	1.20020319
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18426145
37	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.15371494
38	cAMP signaling pathway_Homo sapiens_hsa04024	1.14776138
39	beta-Alanine metabolism_Homo sapiens_hsa00410	1.14211155
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13891704
41	Hippo signaling pathway_Homo sapiens_hsa04390	1.11961171
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.10848400
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.10804978
44	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.10641086
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07959637
46	Renin secretion_Homo sapiens_hsa04924	1.06705523
47	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.05107017
48	Propanoate metabolism_Homo sapiens_hsa00640	1.04622732
49	Insulin secretion_Homo sapiens_hsa04911	1.04180225
50	Glycerolipid metabolism_Homo sapiens_hsa00561	1.01324373
51	Retinol metabolism_Homo sapiens_hsa00830	0.99679217
52	Gastric acid secretion_Homo sapiens_hsa04971	0.99031322
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96959936
54	Cocaine addiction_Homo sapiens_hsa05030	0.96247153
55	Cholinergic synapse_Homo sapiens_hsa04725	0.95470442
56	Homologous recombination_Homo sapiens_hsa03440	0.92371763
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92296086
58	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.92200589
59	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.91451305
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85529853
61	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.81377638
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.80534212
63	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80090933
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79634039
65	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.79416747
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.77557365
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77057892
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76682384
69	Amphetamine addiction_Homo sapiens_hsa05031	0.75956538
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.75475439
71	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.74704023
72	Melanogenesis_Homo sapiens_hsa04916	0.74487511
73	Ras signaling pathway_Homo sapiens_hsa04014	0.71209504
74	Regulation of autophagy_Homo sapiens_hsa04140	0.68087506
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68030839
76	Wnt signaling pathway_Homo sapiens_hsa04310	0.67409186
77	Lysine degradation_Homo sapiens_hsa00310	0.63369432
78	Choline metabolism in cancer_Homo sapiens_hsa05231	0.63143051
79	Basal transcription factors_Homo sapiens_hsa03022	0.62435681
80	Focal adhesion_Homo sapiens_hsa04510	0.62003412
81	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.58900168
82	Adherens junction_Homo sapiens_hsa04520	0.56610180
83	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56438887
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56250884
85	Caffeine metabolism_Homo sapiens_hsa00232	0.53708148
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53306862
87	Tight junction_Homo sapiens_hsa04530	0.51388245
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.50332595
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49682765
90	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.49019914
91	Selenocompound metabolism_Homo sapiens_hsa00450	0.47565024
92	Pancreatic secretion_Homo sapiens_hsa04972	0.45266104
93	Gap junction_Homo sapiens_hsa04540	0.44580042
94	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.44524627
95	Melanoma_Homo sapiens_hsa05218	0.44233592
96	Bile secretion_Homo sapiens_hsa04976	0.43252975
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42396877
98	Platelet activation_Homo sapiens_hsa04611	0.42034654
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41803499
100	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.41170703

CNTNAP3B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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