CNTNAP3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)4.13229532
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97935742
3behavioral response to nicotine (GO:0035095)3.66219250
4detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.61285259
5neural tube formation (GO:0001841)3.57607848
6regulation of hippo signaling (GO:0035330)3.56204777
7cilium movement (GO:0003341)3.46754683
8neuronal action potential propagation (GO:0019227)3.40272500
9pyrimidine nucleobase catabolic process (GO:0006208)3.39140787
10central nervous system projection neuron axonogenesis (GO:0021952)3.34239096
11indolalkylamine metabolic process (GO:0006586)3.33381179
12presynaptic membrane assembly (GO:0097105)3.32079123
13central nervous system neuron axonogenesis (GO:0021955)3.31932421
14tachykinin receptor signaling pathway (GO:0007217)3.31691735
15interkinetic nuclear migration (GO:0022027)3.24277119
16reflex (GO:0060004)3.23646677
17limb bud formation (GO:0060174)3.23043727
18indolalkylamine catabolic process (GO:0046218)3.20887231
19tryptophan catabolic process (GO:0006569)3.20887231
20indole-containing compound catabolic process (GO:0042436)3.20887231
21gamma-aminobutyric acid transport (GO:0015812)3.16896362
22epithelial cilium movement (GO:0003351)3.11524359
23kynurenine metabolic process (GO:0070189)3.10501906
24cerebral cortex radially oriented cell migration (GO:0021799)3.04656575
25limb development (GO:0060173)2.97999892
26appendage development (GO:0048736)2.97999892
27photoreceptor cell maintenance (GO:0045494)2.96860622
28cilium organization (GO:0044782)2.95423380
29inner ear receptor stereocilium organization (GO:0060122)2.94851382
30serotonin metabolic process (GO:0042428)2.94704334
31behavioral response to ethanol (GO:0048149)2.93854431
32regulation of sarcomere organization (GO:0060297)2.92836948
33response to pheromone (GO:0019236)2.92692808
34cilium assembly (GO:0042384)2.92035553
35retinal ganglion cell axon guidance (GO:0031290)2.91143937
36nucleus localization (GO:0051647)2.90623091
37detection of light stimulus involved in visual perception (GO:0050908)2.88211762
38detection of light stimulus involved in sensory perception (GO:0050962)2.88211762
39atrial cardiac muscle cell action potential (GO:0086014)2.86117140
40fucose catabolic process (GO:0019317)2.84901254
41L-fucose metabolic process (GO:0042354)2.84901254
42L-fucose catabolic process (GO:0042355)2.84901254
43positive regulation of action potential (GO:0045760)2.84889493
44cAMP catabolic process (GO:0006198)2.84282631
45signal peptide processing (GO:0006465)2.83982995
46cilium morphogenesis (GO:0060271)2.80018709
47postsynaptic membrane organization (GO:0001941)2.78013369
48regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77170180
49presynaptic membrane organization (GO:0097090)2.77102225
50nucleobase catabolic process (GO:0046113)2.74966602
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.74018711
52regulation of translation, ncRNA-mediated (GO:0045974)2.74018711
53negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74018711
54indole-containing compound metabolic process (GO:0042430)2.73234729
55negative regulation of astrocyte differentiation (GO:0048712)2.70008537
56primary amino compound metabolic process (GO:1901160)2.69569862
57detection of mechanical stimulus involved in sensory perception (GO:0050974)2.68326236
58tryptophan metabolic process (GO:0006568)2.67354248
59nonmotile primary cilium assembly (GO:0035058)2.65828000
60intraciliary transport (GO:0042073)2.59535643
61axoneme assembly (GO:0035082)2.58068067
62motile cilium assembly (GO:0044458)2.57494404
63cellular response to sterol (GO:0036315)2.57000973
64somite development (GO:0061053)2.55459130
65establishment of protein localization to Golgi (GO:0072600)2.55120041
66cyclic nucleotide catabolic process (GO:0009214)2.54188130
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53749091
68retinal cone cell development (GO:0046549)2.53601207
69cellular component assembly involved in morphogenesis (GO:0010927)2.53247274
70regulation of action potential (GO:0098900)2.52656948
71cerebral cortex cell migration (GO:0021795)2.49794806
72glycosphingolipid biosynthetic process (GO:0006688)2.48690437
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48513317
74transmission of nerve impulse (GO:0019226)2.48056086
75smoothened signaling pathway (GO:0007224)2.47497514
76regulation of pigment cell differentiation (GO:0050932)2.45609309
77homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.45166629
78regulation of neuron projection regeneration (GO:0070570)2.44559588
79regulation of axon regeneration (GO:0048679)2.44559588
80vocalization behavior (GO:0071625)2.44135405
81negative chemotaxis (GO:0050919)2.44095062
82startle response (GO:0001964)2.44077469
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.42545706
84regulation of axon guidance (GO:1902667)2.38902116
85axonemal dynein complex assembly (GO:0070286)2.38679806
86membrane depolarization during action potential (GO:0086010)2.38394443
87regulation of collateral sprouting (GO:0048670)2.37244288
88negative regulation of Rho protein signal transduction (GO:0035024)2.36514921
89smooth muscle contraction (GO:0006939)2.36443867
90cornea development in camera-type eye (GO:0061303)2.35861230
91lateral sprouting from an epithelium (GO:0060601)2.32341578
92regulation of non-canonical Wnt signaling pathway (GO:2000050)2.30868251
93neuronal action potential (GO:0019228)2.27539095
94regulation of axon extension involved in axon guidance (GO:0048841)2.25773483
95regulation of cilium movement (GO:0003352)2.24603245
96protein localization to cilium (GO:0061512)2.24379086
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.24106229
98righting reflex (GO:0060013)2.23637373
99establishment of nucleus localization (GO:0040023)2.23414315
100cell proliferation in forebrain (GO:0021846)2.21937197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.64811623
2EZH2_22144423_ChIP-Seq_EOC_Human3.44211745
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.06300617
4VDR_22108803_ChIP-Seq_LS180_Human2.78749878
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77131908
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73849836
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56973457
8ZNF274_21170338_ChIP-Seq_K562_Hela2.51346283
9TAF15_26573619_Chip-Seq_HEK293_Human2.43851164
10IGF1R_20145208_ChIP-Seq_DFB_Human2.31027036
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27199283
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.24473299
13AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.18639953
14PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.17218146
15FUS_26573619_Chip-Seq_HEK293_Human2.15137538
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10756730
17P300_19829295_ChIP-Seq_ESCs_Human2.08386398
18PIAS1_25552417_ChIP-Seq_VCAP_Human2.04752601
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01419389
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93436019
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93104142
22SMAD4_21799915_ChIP-Seq_A2780_Human1.91564791
23EWS_26573619_Chip-Seq_HEK293_Human1.87725537
24STAT3_23295773_ChIP-Seq_U87_Human1.81906711
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78063296
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.74402579
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.72581488
28BCAT_22108803_ChIP-Seq_LS180_Human1.66462483
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66449033
30TP53_16413492_ChIP-PET_HCT116_Human1.65662224
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63386090
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63015468
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63015468
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62890426
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62748728
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62662805
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.62128758
38TCF4_23295773_ChIP-Seq_U87_Human1.61968670
39AR_21572438_ChIP-Seq_LNCaP_Human1.61225830
40ER_23166858_ChIP-Seq_MCF-7_Human1.61064935
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58469525
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54894295
43AR_25329375_ChIP-Seq_VCAP_Human1.51944256
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48553214
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.45122731
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42676815
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41471264
48CBP_20019798_ChIP-Seq_JUKART_Human1.41471264
49RUNX2_22187159_ChIP-Seq_PCA_Human1.39820664
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.36558319
51TCF4_22108803_ChIP-Seq_LS180_Human1.36015940
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35436219
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.34658124
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33239531
55AHR_22903824_ChIP-Seq_MCF-7_Human1.31356363
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31278983
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31278983
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30078566
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29760604
60CJUN_26792858_Chip-Seq_BT549_Human1.29666475
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29102883
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.26675535
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.26337053
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25208527
65DROSHA_22980978_ChIP-Seq_HELA_Human1.25023820
66RNF2_27304074_Chip-Seq_NSC_Mouse1.24412983
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23756274
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.22977054
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20990022
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19696173
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19224411
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18547903
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18363067
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18219276
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17442788
76TP53_18474530_ChIP-ChIP_U2OS_Human1.17303285
77REST_21632747_ChIP-Seq_MESCs_Mouse1.16828819
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.16737680
79SMAD4_21741376_ChIP-Seq_EPCs_Human1.16264243
80KDM2B_26808549_Chip-Seq_REH_Human1.15478064
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.14389070
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13922153
83JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10603497
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.10014446
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09972459
86P53_22387025_ChIP-Seq_ESCs_Mouse1.09759962
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09697270
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09499163
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08922639
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.08512314
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08051920
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07379967
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06990014
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06774988
95CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06391773
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06316330
97E2F1_18555785_Chip-Seq_ESCs_Mouse1.06160043
98EZH2_27304074_Chip-Seq_ESCs_Mouse1.03984466
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03017536
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02389142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.15200599
2MP0003136_yellow_coat_color2.43283523
3MP0003880_abnormal_central_pattern2.18132431
4MP0000566_synostosis2.16516760
5MP0001968_abnormal_touch/_nociception2.11893652
6MP0002102_abnormal_ear_morphology2.08803218
7MP0010386_abnormal_urinary_bladder2.03468806
8MP0005551_abnormal_eye_electrophysiolog2.00044573
9MP0000778_abnormal_nervous_system1.93820010
10MP0004215_abnormal_myocardial_fiber1.92782432
11MP0000427_abnormal_hair_cycle1.92380208
12MP0002736_abnormal_nociception_after1.92169036
13MP0001486_abnormal_startle_reflex1.91289917
14MP0006292_abnormal_olfactory_placode1.89966583
15MP0009046_muscle_twitch1.87756052
16MP0001984_abnormal_olfaction1.82708898
17MP0005167_abnormal_blood-brain_barrier1.71005359
18MP0009745_abnormal_behavioral_response1.69107971
19MP0001501_abnormal_sleep_pattern1.69035780
20MP0003195_calcinosis1.67480357
21MP0006276_abnormal_autonomic_nervous1.65268857
22MP0000383_abnormal_hair_follicle1.64674408
23MP0002938_white_spotting1.61076787
24MP0003950_abnormal_plasma_membrane1.59635566
25MP0002735_abnormal_chemical_nociception1.53311742
26MP0005386_behavior/neurological_phenoty1.51442220
27MP0004924_abnormal_behavior1.51442220
28MP0004145_abnormal_muscle_electrophysio1.51303953
29MP0005171_absent_coat_pigmentation1.51142962
30MP0005187_abnormal_penis_morphology1.46844951
31MP0005248_abnormal_Harderian_gland1.44644461
32MP0004043_abnormal_pH_regulation1.44360870
33MP0002572_abnormal_emotion/affect_behav1.41263373
34MP0004133_heterotaxia1.40260287
35MP0003635_abnormal_synaptic_transmissio1.39752375
36MP0004885_abnormal_endolymph1.39511665
37MP0005253_abnormal_eye_physiology1.39490957
38MP0003937_abnormal_limbs/digits/tail_de1.39484268
39MP0000631_abnormal_neuroendocrine_gland1.38606403
40MP0005174_abnormal_tail_pigmentation1.36913106
41MP0000049_abnormal_middle_ear1.35116436
42MP0002272_abnormal_nervous_system1.34970224
43MP0001879_abnormal_lymphatic_vessel1.31243115
44MP0002234_abnormal_pharynx_morphology1.25285922
45MP0010368_abnormal_lymphatic_system1.25038843
46MP0001293_anophthalmia1.24458523
47MP0002233_abnormal_nose_morphology1.23309424
48MP0002067_abnormal_sensory_capabilities1.23135016
49MP0002063_abnormal_learning/memory/cond1.22387991
50MP0004142_abnormal_muscle_tone1.21556741
51MP0004859_abnormal_synaptic_plasticity1.20762183
52MP0002064_seizures1.16874127
53MP0003890_abnormal_embryonic-extraembry1.15700519
54MP0010030_abnormal_orbit_morphology1.14696775
55MP0004484_altered_response_of1.14056151
56MP0003119_abnormal_digestive_system1.14049220
57MP0008877_abnormal_DNA_methylation1.13035626
58MP0002653_abnormal_ependyma_morphology1.12917481
59MP0005195_abnormal_posterior_eye1.12437195
60MP0003787_abnormal_imprinting1.10082966
61MP0005377_hearing/vestibular/ear_phenot1.09770515
62MP0003878_abnormal_ear_physiology1.09770515
63MP0002638_abnormal_pupillary_reflex1.08326410
64MP0002168_other_aberrant_phenotype1.07679451
65MP0005646_abnormal_pituitary_gland1.07427493
66MP0002184_abnormal_innervation1.06289807
67MP0009053_abnormal_anal_canal1.06042625
68MP0001440_abnormal_grooming_behavior1.05623674
69MP0008057_abnormal_DNA_replication1.04435506
70MP0002752_abnormal_somatic_nervous1.03523875
71MP0001485_abnormal_pinna_reflex1.03132991
72MP0001970_abnormal_pain_threshold1.02974292
73MP0000647_abnormal_sebaceous_gland1.02797630
74MP0000026_abnormal_inner_ear1.00966158
75MP0005670_abnormal_white_adipose0.99984038
76MP0002557_abnormal_social/conspecific_i0.97915284
77MP0008789_abnormal_olfactory_epithelium0.97510533
78MP0000428_abnormal_craniofacial_morphol0.96557772
79MP0003045_fibrosis0.95026811
80MP0001299_abnormal_eye_distance/0.95023697
81MP0010678_abnormal_skin_adnexa0.94489905
82MP0000955_abnormal_spinal_cord0.93377270
83MP0005391_vision/eye_phenotype0.92656749
84MP0002882_abnormal_neuron_morphology0.92377376
85MP0000230_abnormal_systemic_arterial0.91436754
86MP0003755_abnormal_palate_morphology0.90184770
87MP0003121_genomic_imprinting0.89643848
88MP0004085_abnormal_heartbeat0.89267543
89MP0005595_abnormal_vascular_smooth0.87560940
90MP0003646_muscle_fatigue0.86399343
91MP0003137_abnormal_impulse_conducting0.86344102
92MP0004272_abnormal_basement_membrane0.86332735
93MP0008872_abnormal_physiological_respon0.84984438
94MP0002282_abnormal_trachea_morphology0.82666986
95MP0002733_abnormal_thermal_nociception0.82514641
96MP0002734_abnormal_mechanical_nocicepti0.81885162
97MP0004130_abnormal_muscle_cell0.81544005
98MP0003252_abnormal_bile_duct0.81074690
99MP0002928_abnormal_bile_duct0.80661561
100MP0006072_abnormal_retinal_apoptosis0.80522767

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.18987378
2Pancreatic fibrosis (HP:0100732)4.01947994
3True hermaphroditism (HP:0010459)4.01401685
4Hyperventilation (HP:0002883)3.84444101
5Molar tooth sign on MRI (HP:0002419)3.58156628
6Abnormality of midbrain morphology (HP:0002418)3.58156628
7Nephronophthisis (HP:0000090)3.47624158
8Abnormality of the renal medulla (HP:0100957)3.29599293
9Gaze-evoked nystagmus (HP:0000640)3.26363130
10Abnormal ciliary motility (HP:0012262)3.22958932
11Cystic liver disease (HP:0006706)3.05617938
12Genetic anticipation (HP:0003743)3.02374233
13Absent/shortened dynein arms (HP:0200106)2.99723951
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.99723951
15Progressive cerebellar ataxia (HP:0002073)2.94526033
16Aplasia/Hypoplasia of the tibia (HP:0005772)2.83148788
17Febrile seizures (HP:0002373)2.74344723
18Chronic hepatic failure (HP:0100626)2.71747912
19Aplasia/Hypoplasia of the tongue (HP:0010295)2.69757332
20Focal seizures (HP:0007359)2.67633395
21Abnormal respiratory motile cilium physiology (HP:0012261)2.66662849
22Abnormality of the renal cortex (HP:0011035)2.63894089
23Congenital stationary night blindness (HP:0007642)2.61514827
24Fair hair (HP:0002286)2.56174341
25Focal motor seizures (HP:0011153)2.52989849
26Medial flaring of the eyebrow (HP:0010747)2.51195384
27Protruding tongue (HP:0010808)2.44025927
28Absent speech (HP:0001344)2.43868205
29Decreased central vision (HP:0007663)2.41993109
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41762877
31Short 4th metacarpal (HP:0010044)2.41762877
32Abnormal respiratory motile cilium morphology (HP:0005938)2.38498207
33Abnormal respiratory epithelium morphology (HP:0012253)2.38498207
34Postaxial foot polydactyly (HP:0001830)2.37565222
35Keratoconus (HP:0000563)2.37088960
36Increased corneal curvature (HP:0100692)2.37088960
37Tubular atrophy (HP:0000092)2.36875877
38Genital tract atresia (HP:0001827)2.34657228
39Congenital hepatic fibrosis (HP:0002612)2.34488783
40Attenuation of retinal blood vessels (HP:0007843)2.28817970
41Sclerocornea (HP:0000647)2.28729885
42Preaxial foot polydactyly (HP:0001841)2.28392427
43Occipital encephalocele (HP:0002085)2.27171744
44Cutaneous finger syndactyly (HP:0010554)2.22618573
45Drooling (HP:0002307)2.22492537
46Vaginal atresia (HP:0000148)2.21951873
47Broad-based gait (HP:0002136)2.20371243
48Hypoplastic labia majora (HP:0000059)2.15660561
49Type II lissencephaly (HP:0007260)2.13974997
50Gait imbalance (HP:0002141)2.12317110
51Anencephaly (HP:0002323)2.11167937
52Chorioretinal atrophy (HP:0000533)2.09945935
53Generalized hypopigmentation of hair (HP:0011358)2.09192792
54Preaxial hand polydactyly (HP:0001177)2.05841049
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.04621111
56Cutaneous syndactyly (HP:0012725)2.04590731
57Optic nerve hypoplasia (HP:0000609)2.03830903
58Long nose (HP:0003189)2.03470107
59Inability to walk (HP:0002540)2.00506941
60Abnormality of the ischium (HP:0003174)1.99654078
61Excessive salivation (HP:0003781)1.99575415
62Congenital primary aphakia (HP:0007707)1.99160128
63Postaxial hand polydactyly (HP:0001162)1.98857045
64Widely spaced teeth (HP:0000687)1.98137260
65Progressive inability to walk (HP:0002505)1.97667735
66Clumsiness (HP:0002312)1.96486159
67Abnormality of the labia majora (HP:0012881)1.92098712
68Aplasia involving bones of the upper limbs (HP:0009823)1.91962037
69Aplasia of the phalanges of the hand (HP:0009802)1.91962037
70Aplasia involving bones of the extremities (HP:0009825)1.91962037
71Furrowed tongue (HP:0000221)1.89873939
72Hemiparesis (HP:0001269)1.86790894
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84440098
74Lissencephaly (HP:0001339)1.84000378
75Anophthalmia (HP:0000528)1.82283297
76Nephrogenic diabetes insipidus (HP:0009806)1.82173580
77Tracheomalacia (HP:0002779)1.82046959
78Narrow forehead (HP:0000341)1.77487005
79Tented upper lip vermilion (HP:0010804)1.76692648
80Cerebellar dysplasia (HP:0007033)1.76428442
81Hypoplastic ischia (HP:0003175)1.75540748
82Renal hypoplasia (HP:0000089)1.74813669
83Abnormality of the 4th metacarpal (HP:0010012)1.74237131
84Abnormality of the nasal septum (HP:0000419)1.73507099
85Blue irides (HP:0000635)1.72673949
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71956716
87Short foot (HP:0001773)1.71943796
88Fibular hypoplasia (HP:0003038)1.69861511
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68286087
90Hypoplastic iliac wings (HP:0002866)1.68045294
91Pendular nystagmus (HP:0012043)1.67979192
92Dyskinesia (HP:0100660)1.67612968
93Renal dysplasia (HP:0000110)1.66630515
94Supernumerary spleens (HP:0009799)1.65493860
95Short tibia (HP:0005736)1.65323226
96Polydipsia (HP:0001959)1.65181964
97Abnormal drinking behavior (HP:0030082)1.65181964
98Median cleft lip (HP:0000161)1.64549394
99Exotropia (HP:0000577)1.64508366
100Rhinitis (HP:0012384)1.63622503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.77156996
2BMPR1B3.18077793
3ACVR1B2.81410261
4CASK2.72684548
5TIE12.24487678
6EPHA42.23712780
7TNIK2.20721557
8MAP3K42.08387068
9WNK32.07085976
10STK38L2.06012882
11NTRK31.98769313
12MARK11.85741047
13MAPK131.77275371
14MKNK21.73077986
15TGFBR11.70672299
16ADRBK21.66408767
17INSRR1.54194720
18NTRK21.49635875
19MAP4K21.43686565
20STK391.41924509
21PTK2B1.38519527
22WNK41.38164267
23DMPK1.30848652
24NUAK11.28235771
25CAMKK21.26859741
26PAK31.26841891
27PINK11.25925788
28OXSR11.23922778
29PNCK1.20801048
30MAP2K71.19811159
31EPHB21.19660924
32LATS11.18180755
33BRSK21.17945423
34PRKCE1.16594461
35GRK11.13051305
36ADRBK11.12944919
37STK31.12446259
38MKNK11.10819706
39BCR1.09500427
40FGFR21.08089857
41ERBB31.03911906
42MET0.96335384
43MAP3K70.89089805
44PLK20.87916421
45PRKCG0.84899950
46STK240.84875226
47PIK3CA0.84299104
48FER0.83185994
49WNK10.82768172
50NLK0.78094127
51DAPK20.76429882
52SGK20.75137666
53STK110.72222071
54MYLK0.72010591
55MAP2K40.71183080
56CAMK2A0.69942560
57TRIM280.69372155
58ZAK0.68647098
59CAMK1G0.68228548
60PRKAA20.65345990
61CSNK1G20.65164001
62PKN10.64819831
63ERBB20.62912637
64IRAK10.62287987
65FGFR10.60549947
66PIK3CG0.59041866
67STK380.56691695
68AKT30.55731294
69ROCK10.55659398
70TGFBR20.54832780
71MELK0.53295609
72WEE10.53166549
73CAMK10.52654835
74CAMK1D0.52325043
75DYRK20.50623882
76CSNK1A1L0.47733779
77DYRK1A0.46945672
78CAMK40.46230853
79CSNK1D0.46029650
80TLK10.45653990
81NTRK10.45405239
82CSNK1G10.45404896
83TAOK30.44033994
84TRPM70.43682489
85EPHA30.43081479
86CDK30.40924792
87DYRK30.40900811
88KSR10.40101443
89PRKAA10.38287057
90MAP2K10.37798677
91CDK50.37362408
92PHKG10.36712228
93PHKG20.36712228
94SGK4940.36644829
95SGK2230.36644829
96PAK60.35165252
97PRKACA0.33982636
98MAPK70.32416330
99MAPK150.31219783
100MAPKAPK50.30516782

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.85418415
2Linoleic acid metabolism_Homo sapiens_hsa005912.09762015
3Nitrogen metabolism_Homo sapiens_hsa009102.06201181
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04026567
5Phototransduction_Homo sapiens_hsa047441.98170686
6Taste transduction_Homo sapiens_hsa047421.93831991
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93522701
8Morphine addiction_Homo sapiens_hsa050321.90538462
9Glutamatergic synapse_Homo sapiens_hsa047241.87914897
10Circadian entrainment_Homo sapiens_hsa047131.80334287
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78189582
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77997825
13Olfactory transduction_Homo sapiens_hsa047401.76341463
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73523706
15Butanoate metabolism_Homo sapiens_hsa006501.70016762
16ABC transporters_Homo sapiens_hsa020101.68280641
17Hedgehog signaling pathway_Homo sapiens_hsa043401.63059087
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58298346
19Dorso-ventral axis formation_Homo sapiens_hsa043201.57445337
20Ether lipid metabolism_Homo sapiens_hsa005651.54883051
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54770964
22Tryptophan metabolism_Homo sapiens_hsa003801.51376340
23Serotonergic synapse_Homo sapiens_hsa047261.50800027
24Histidine metabolism_Homo sapiens_hsa003401.49382047
25Circadian rhythm_Homo sapiens_hsa047101.44590301
26Axon guidance_Homo sapiens_hsa043601.43228386
27GABAergic synapse_Homo sapiens_hsa047271.42389197
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.39139499
29Basal cell carcinoma_Homo sapiens_hsa052171.37389481
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35596330
31Salivary secretion_Homo sapiens_hsa049701.33164177
32Long-term depression_Homo sapiens_hsa047301.27602920
33ECM-receptor interaction_Homo sapiens_hsa045121.25293087
34Calcium signaling pathway_Homo sapiens_hsa040201.21049417
35Dopaminergic synapse_Homo sapiens_hsa047281.20020319
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18426145
37Ovarian steroidogenesis_Homo sapiens_hsa049131.15371494
38cAMP signaling pathway_Homo sapiens_hsa040241.14776138
39beta-Alanine metabolism_Homo sapiens_hsa004101.14211155
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13891704
41Hippo signaling pathway_Homo sapiens_hsa043901.11961171
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10848400
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10804978
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10641086
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.07959637
46Renin secretion_Homo sapiens_hsa049241.06705523
47Oxytocin signaling pathway_Homo sapiens_hsa049211.05107017
48Propanoate metabolism_Homo sapiens_hsa006401.04622732
49Insulin secretion_Homo sapiens_hsa049111.04180225
50Glycerolipid metabolism_Homo sapiens_hsa005611.01324373
51Retinol metabolism_Homo sapiens_hsa008300.99679217
52Gastric acid secretion_Homo sapiens_hsa049710.99031322
53Fanconi anemia pathway_Homo sapiens_hsa034600.96959936
54Cocaine addiction_Homo sapiens_hsa050300.96247153
55Cholinergic synapse_Homo sapiens_hsa047250.95470442
56Homologous recombination_Homo sapiens_hsa034400.92371763
57Chemical carcinogenesis_Homo sapiens_hsa052040.92296086
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92200589
59Dilated cardiomyopathy_Homo sapiens_hsa054140.91451305
60Arachidonic acid metabolism_Homo sapiens_hsa005900.85529853
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81377638
62Fatty acid biosynthesis_Homo sapiens_hsa000610.80534212
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80090933
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.79634039
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79416747
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77557365
67TGF-beta signaling pathway_Homo sapiens_hsa043500.77057892
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76682384
69Amphetamine addiction_Homo sapiens_hsa050310.75956538
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75475439
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74704023
72Melanogenesis_Homo sapiens_hsa049160.74487511
73Ras signaling pathway_Homo sapiens_hsa040140.71209504
74Regulation of autophagy_Homo sapiens_hsa041400.68087506
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68030839
76Wnt signaling pathway_Homo sapiens_hsa043100.67409186
77Lysine degradation_Homo sapiens_hsa003100.63369432
78Choline metabolism in cancer_Homo sapiens_hsa052310.63143051
79Basal transcription factors_Homo sapiens_hsa030220.62435681
80Focal adhesion_Homo sapiens_hsa045100.62003412
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58900168
82Adherens junction_Homo sapiens_hsa045200.56610180
83Rap1 signaling pathway_Homo sapiens_hsa040150.56438887
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56250884
85Caffeine metabolism_Homo sapiens_hsa002320.53708148
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.53306862
87Tight junction_Homo sapiens_hsa045300.51388245
88Sphingolipid metabolism_Homo sapiens_hsa006000.50332595
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49682765
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.49019914
91Selenocompound metabolism_Homo sapiens_hsa004500.47565024
92Pancreatic secretion_Homo sapiens_hsa049720.45266104
93Gap junction_Homo sapiens_hsa045400.44580042
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44524627
95Melanoma_Homo sapiens_hsa052180.44233592
96Bile secretion_Homo sapiens_hsa049760.43252975
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42396877
98Platelet activation_Homo sapiens_hsa046110.42034654
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41803499
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41170703

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