ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	heparin biosynthetic process (GO:0030210)	9.05446879
2	heparin metabolic process (GO:0030202)	9.05446879
3	leukotriene biosynthetic process (GO:0019370)	5.57001992
4	prenylation (GO:0097354)	5.10810103
5	protein prenylation (GO:0018342)	5.10810103
6	exocrine pancreas development (GO:0031017)	4.81120133
7	viral mRNA export from host cell nucleus (GO:0046784)	4.74966094
8	neurotransmitter-gated ion channel clustering (GO:0072578)	4.55293715
9	replication fork processing (GO:0031297)	4.51821580
10	protein complex biogenesis (GO:0070271)	4.14747509
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.14684035
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.14684035
13	NADH dehydrogenase complex assembly (GO:0010257)	4.14684035
14	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.08334860
15	dentate gyrus development (GO:0021542)	4.03718008
16	retinal cone cell development (GO:0046549)	3.84943432
17	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	3.84013858
18	regulation of germinal center formation (GO:0002634)	3.76395778
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.74674337
20	interferon-gamma secretion (GO:0072643)	3.66598049
21	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.66097796
22	regulation of sarcomere organization (GO:0060297)	3.63617701
23	icosanoid biosynthetic process (GO:0046456)	3.63597762
24	fatty acid derivative biosynthetic process (GO:1901570)	3.63597762
25	neural tube formation (GO:0001841)	3.61190204
26	translesion synthesis (GO:0019985)	3.54390318
27	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.52358516
28	myelin assembly (GO:0032288)	3.49429363
29	leukotriene metabolic process (GO:0006691)	3.46928783
30	epithelial cell differentiation involved in kidney development (GO:0035850)	3.42598899
31	reciprocal meiotic recombination (GO:0007131)	3.34822255
32	reciprocal DNA recombination (GO:0035825)	3.34822255
33	microglial cell activation (GO:0001774)	3.26040452
34	negative regulation of protein oligomerization (GO:0032460)	3.22207332
35	rRNA catabolic process (GO:0016075)	3.20352526
36	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.19868916
37	positive regulation of lamellipodium assembly (GO:0010592)	3.17029961
38	autophagic vacuole fusion (GO:0000046)	3.16728037
39	cornea development in camera-type eye (GO:0061303)	3.13572250
40	cellular response to interleukin-15 (GO:0071350)	3.12552908
41	adenosine metabolic process (GO:0046085)	3.09822941
42	Sertoli cell development (GO:0060009)	3.06653181
43	nonmotile primary cilium assembly (GO:0035058)	3.03627296
44	histone H2A acetylation (GO:0043968)	2.98690968
45	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.97363637
46	coenzyme catabolic process (GO:0009109)	2.93969254
47	intraciliary transport (GO:0042073)	2.93836819
48	heart field specification (GO:0003128)	2.92329739
49	secondary heart field specification (GO:0003139)	2.92329739
50	response to vitamin E (GO:0033197)	2.90239251
51	embryonic epithelial tube formation (GO:0001838)	2.88627254
52	photoreceptor cell maintenance (GO:0045494)	2.87320154
53	unsaturated fatty acid biosynthetic process (GO:0006636)	2.85174289
54	regulation of chromatin silencing (GO:0031935)	2.83429617
55	rRNA methylation (GO:0031167)	2.82165049
56	negative regulation of stress fiber assembly (GO:0051497)	2.80377577
57	aggressive behavior (GO:0002118)	2.80233810
58	protein heterotetramerization (GO:0051290)	2.78137843
59	mitochondrial DNA replication (GO:0006264)	2.76591131
60	mechanosensory behavior (GO:0007638)	2.75526666
61	epithelial tube formation (GO:0072175)	2.67734964
62	regulation of timing of cell differentiation (GO:0048505)	2.67214280
63	inner ear receptor stereocilium organization (GO:0060122)	2.67056149
64	UV protection (GO:0009650)	2.65786211
65	positive regulation of B cell differentiation (GO:0045579)	2.64404844
66	specification of organ identity (GO:0010092)	2.62869516
67	regulation of respiratory burst (GO:0060263)	2.62690727
68	protein sumoylation (GO:0016925)	2.62540460
69	regulation of female gonad development (GO:2000194)	2.62169741
70	rhodopsin mediated signaling pathway (GO:0016056)	2.60367749
71	mitochondrial genome maintenance (GO:0000002)	2.59747053
72	cell wall macromolecule catabolic process (GO:0016998)	2.56602649
73	presynaptic membrane assembly (GO:0097105)	2.56367827
74	positive regulation of interleukin-17 production (GO:0032740)	2.56076530
75	negative regulation of actin filament bundle assembly (GO:0032232)	2.56015296
76	rRNA modification (GO:0000154)	2.54835656
77	regulation of male gonad development (GO:2000018)	2.54487360
78	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.53774407
79	positive regulation of muscle hypertrophy (GO:0014742)	2.53774407
80	transcription from mitochondrial promoter (GO:0006390)	2.53589804
81	regulation of helicase activity (GO:0051095)	2.53508152
82	sleep (GO:0030431)	2.53383152
83	glycerophospholipid catabolic process (GO:0046475)	2.53016467
84	regulation of hippo signaling (GO:0035330)	2.52883064
85	protein localization to cilium (GO:0061512)	2.52081549
86	retina layer formation (GO:0010842)	2.51995592
87	androgen biosynthetic process (GO:0006702)	2.51168728
88	regulation of pigment cell differentiation (GO:0050932)	2.51000148
89	indole-containing compound catabolic process (GO:0042436)	2.50498485
90	indolalkylamine catabolic process (GO:0046218)	2.50498485
91	tryptophan catabolic process (GO:0006569)	2.50498485
92	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.49396134
93	lateral sprouting from an epithelium (GO:0060601)	2.48717620
94	righting reflex (GO:0060013)	2.48708910
95	cell differentiation involved in metanephros development (GO:0072202)	2.48341023
96	single strand break repair (GO:0000012)	2.48308739
97	postreplication repair (GO:0006301)	2.48249843
98	negative regulation of cation channel activity (GO:2001258)	2.47705509
99	mitochondrion distribution (GO:0048311)	2.47689220
100	cell differentiation involved in kidney development (GO:0061005)	2.47423826

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.37548448
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.07819511
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.63835666
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.58193152
5	VDR_22108803_ChIP-Seq_LS180_Human	3.18131684
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.92855268
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.87662979
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.86768301
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.72873219
10	EWS_26573619_Chip-Seq_HEK293_Human	2.36891749
11	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.30997584
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26257075
13	P300_19829295_ChIP-Seq_ESCs_Human	2.25005040
14	GATA1_22025678_ChIP-Seq_K562_Human	2.23349509
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.22172054
16	FUS_26573619_Chip-Seq_HEK293_Human	2.20866098
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17300185
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06614849
19	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.94259579
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.88805194
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.85924101
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81018950
23	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.81018950
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72436380
25	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.71967604
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.69677495
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.67449633
28	TCF4_23295773_ChIP-Seq_U87_Human	1.64314180
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62477501
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61928084
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.60944496
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60245111
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59704260
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.59506076
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57591858
36	STAT3_23295773_ChIP-Seq_U87_Human	1.55696198
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54552564
38	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.54106768
39	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.50371412
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48354936
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47474668
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45253364
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45078425
44	AR_25329375_ChIP-Seq_VCAP_Human	1.44351768
45	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.43185345
46	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.40443555
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.39627719
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35751142
49	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.34903610
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33829873
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.32752562
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31311432
53	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.30881143
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30000793
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.27879835
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27119796
57	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.24577105
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24353247
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.23363674
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.22786313
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21211134
62	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20813151
63	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.19730588
64	DROSHA_22980978_ChIP-Seq_HELA_Human	1.18932258
65	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18526341
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16346082
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15764662
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11760730
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10677198
70	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10160314
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07504758
72	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.06842762
73	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.06686981
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06660436
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06488756
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06484572
77	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05155098
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.04603418
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04603418
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.04582032
81	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04397841
82	MYC_18940864_ChIP-ChIP_HL60_Human	1.04343745
83	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04342953
84	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04264594
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04264594
86	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03647193
87	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.02950170
88	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.02370548
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02240223
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99717141
91	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99510950
92	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.98751647
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.98187942
94	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.97638037
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97565269
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.97086801
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.97086801
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96165737
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95467170
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.94610461

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	5.04339106
2	MP0002822_catalepsy	4.41282760
3	MP0001968_abnormal_touch/_nociception	4.11292595
4	MP0002735_abnormal_chemical_nociception	3.46335468
5	MP0004043_abnormal_pH_regulation	2.88711590
6	MP0001486_abnormal_startle_reflex	2.43112518
7	MP0006292_abnormal_olfactory_placode	2.41202349
8	MP0003878_abnormal_ear_physiology	2.36031340
9	MP0005377_hearing/vestibular/ear_phenot	2.36031340
10	MP0005220_abnormal_exocrine_pancreas	2.35536872
11	MP0003121_genomic_imprinting	2.25260771
12	MP0003183_abnormal_peptide_metabolism	2.19009970
13	MP0008877_abnormal_DNA_methylation	2.16163377
14	MP0009697_abnormal_copulation	2.15171685
15	MP0005551_abnormal_eye_electrophysiolog	2.09796074
16	MP0003787_abnormal_imprinting	2.08614942
17	MP0008260_abnormal_autophagy	1.82938292
18	MP0008789_abnormal_olfactory_epithelium	1.76923034
19	MP0009053_abnormal_anal_canal	1.76251321
20	MP0002102_abnormal_ear_morphology	1.73416925
21	MP0001501_abnormal_sleep_pattern	1.73025808
22	MP0005646_abnormal_pituitary_gland	1.69101283
23	MP0002396_abnormal_hematopoietic_system	1.67070791
24	MP0001984_abnormal_olfaction	1.65042087
25	MP0003283_abnormal_digestive_organ	1.63127599
26	MP0009046_muscle_twitch	1.56329825
27	MP0001986_abnormal_taste_sensitivity	1.53276334
28	MP0006036_abnormal_mitochondrial_physio	1.50060652
29	MP0003806_abnormal_nucleotide_metabolis	1.45405556
30	MP0002272_abnormal_nervous_system	1.45067345
31	MP0008875_abnormal_xenobiotic_pharmacok	1.43460948
32	MP0003122_maternal_imprinting	1.42180558
33	MP0001970_abnormal_pain_threshold	1.39028490
34	MP0003880_abnormal_central_pattern	1.35973746
35	MP0005367_renal/urinary_system_phenotyp	1.34421225
36	MP0000516_abnormal_urinary_system	1.34421225
37	MP0006035_abnormal_mitochondrial_morpho	1.33345645
38	MP0001905_abnormal_dopamine_level	1.30109120
39	MP0001502_abnormal_circadian_rhythm	1.29218078
40	MP0000465_gastrointestinal_hemorrhage	1.28136800
41	MP0003195_calcinosis	1.27027751
42	MP0000383_abnormal_hair_follicle	1.26188906
43	MP0006276_abnormal_autonomic_nervous	1.25467081
44	MP0005499_abnormal_olfactory_system	1.24127439
45	MP0005394_taste/olfaction_phenotype	1.24127439
46	MP0005386_behavior/neurological_phenoty	1.23764634
47	MP0004924_abnormal_behavior	1.23764634
48	MP0002733_abnormal_thermal_nociception	1.23684198
49	MP0006072_abnormal_retinal_apoptosis	1.23509256
50	MP0010386_abnormal_urinary_bladder	1.21570183
51	MP0002067_abnormal_sensory_capabilities	1.18136625
52	MP0001485_abnormal_pinna_reflex	1.17725310
53	MP0003786_premature_aging	1.17068874
54	MP0009745_abnormal_behavioral_response	1.17036521
55	MP0000427_abnormal_hair_cycle	1.14242925
56	MP0004142_abnormal_muscle_tone	1.13269170
57	MP0000372_irregular_coat_pigmentation	1.12997697
58	MP0002638_abnormal_pupillary_reflex	1.12764800
59	MP0008058_abnormal_DNA_repair	1.11919745
60	MP0005464_abnormal_platelet_physiology	1.10967163
61	MP0009765_abnormal_xenobiotic_induced	1.10830977
62	MP0004859_abnormal_synaptic_plasticity	1.10783050
63	MP0008569_lethality_at_weaning	1.08676570
64	MP0005253_abnormal_eye_physiology	1.04870572
65	MP0001529_abnormal_vocalization	1.03965188
66	MP0000631_abnormal_neuroendocrine_gland	0.99193481
67	MP0004215_abnormal_myocardial_fiber	0.98354723
68	MP0001177_atelectasis	0.97407510
69	MP0002557_abnormal_social/conspecific_i	0.97260022
70	MP0003123_paternal_imprinting	0.95220353
71	MP0005410_abnormal_fertilization	0.92096671
72	MP0009780_abnormal_chondrocyte_physiolo	0.91209412
73	MP0002572_abnormal_emotion/affect_behav	0.91027156
74	MP0010368_abnormal_lymphatic_system	0.90214565
75	MP0002064_seizures	0.89432948
76	MP0000230_abnormal_systemic_arterial	0.89184069
77	MP0001756_abnormal_urination	0.88392647
78	MP0002138_abnormal_hepatobiliary_system	0.87794999
79	MP0001440_abnormal_grooming_behavior	0.85036178
80	MP0003635_abnormal_synaptic_transmissio	0.84927119
81	MP0002909_abnormal_adrenal_gland	0.84017830
82	MP0008995_early_reproductive_senescence	0.83476505
83	MP0002938_white_spotting	0.82376758
84	MP0003119_abnormal_digestive_system	0.80613834
85	MP0008872_abnormal_physiological_respon	0.77292920
86	MP0003698_abnormal_male_reproductive	0.76599052
87	MP0005535_abnormal_body_temperature	0.76518255
88	MP0003137_abnormal_impulse_conducting	0.74697934
89	MP0001919_abnormal_reproductive_system	0.72654761
90	MP0002332_abnormal_exercise_endurance	0.72335510
91	MP0002229_neurodegeneration	0.69994449
92	MP0008873_increased_physiological_sensi	0.68703571
93	MP0005645_abnormal_hypothalamus_physiol	0.66872187
94	MP0002090_abnormal_vision	0.66858014
95	MP0001929_abnormal_gametogenesis	0.65891161
96	MP0002063_abnormal_learning/memory/cond	0.65474791
97	MP0008007_abnormal_cellular_replicative	0.64589094
98	MP0004130_abnormal_muscle_cell	0.62652531
99	MP0002132_abnormal_respiratory_system	0.62329357
100	MP0001915_intracranial_hemorrhage	0.62267067

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abolished electroretinogram (ERG) (HP:0000550)	6.46109870
2	Dyschromatopsia (HP:0007641)	4.66918278
3	Tubulointerstitial nephritis (HP:0001970)	4.41233833
4	Progressive inability to walk (HP:0002505)	4.20583960
5	Hypoplastic nipples (HP:0002557)	3.94822760
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.82676762
7	Absent/shortened dynein arms (HP:0200106)	3.82676762
8	Peripheral hypomyelination (HP:0007182)	3.42223954
9	Central scotoma (HP:0000603)	3.34672690
10	Renal hypoplasia (HP:0000089)	3.23807008
11	Bony spicule pigmentary retinopathy (HP:0007737)	3.15854131
12	Epileptic encephalopathy (HP:0200134)	3.12288959
13	Generalized aminoaciduria (HP:0002909)	3.07010365
14	Inability to walk (HP:0002540)	3.00184156
15	Clumsiness (HP:0002312)	2.95947158
16	Medial flaring of the eyebrow (HP:0010747)	2.95925868
17	Hypoglycemic coma (HP:0001325)	2.94041638
18	Scotoma (HP:0000575)	2.80995557
19	Attenuation of retinal blood vessels (HP:0007843)	2.77124519
20	Amyotrophic lateral sclerosis (HP:0007354)	2.71337871
21	Nephronophthisis (HP:0000090)	2.68850034
22	Adactyly (HP:0009776)	2.66035032
23	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.60123768
24	Submucous cleft hard palate (HP:0000176)	2.59577582
25	Broad-based gait (HP:0002136)	2.56715151
26	Abnormal ciliary motility (HP:0012262)	2.54956235
27	Febrile seizures (HP:0002373)	2.54412440
28	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.53795447
29	Abnormality of midbrain morphology (HP:0002418)	2.50998773
30	Molar tooth sign on MRI (HP:0002419)	2.50998773
31	Abnormality of macular pigmentation (HP:0008002)	2.50931373
32	Decreased central vision (HP:0007663)	2.50665946
33	Tented upper lip vermilion (HP:0010804)	2.46561740
34	Abnormal hair whorl (HP:0010721)	2.46009337
35	Bifid scrotum (HP:0000048)	2.45234241
36	Wide intermamillary distance (HP:0006610)	2.41424564
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.33732146
38	Bilateral microphthalmos (HP:0007633)	2.33285917
39	Gaze-evoked nystagmus (HP:0000640)	2.32667642
40	Pancreatic cysts (HP:0001737)	2.30995766
41	Thyroid-stimulating hormone excess (HP:0002925)	2.30066204
42	Visual hallucinations (HP:0002367)	2.27917764
43	Hepatic necrosis (HP:0002605)	2.27163445
44	Gait imbalance (HP:0002141)	2.23679732
45	Poor eye contact (HP:0000817)	2.23067821
46	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.18325179
47	Congenital primary aphakia (HP:0007707)	2.16652975
48	Macular degeneration (HP:0000608)	2.16591906
49	Distal arthrogryposis (HP:0005684)	2.15682769
50	Proximal tubulopathy (HP:0000114)	2.15661931
51	Widely spaced teeth (HP:0000687)	2.12659231
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.12501048
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12501048
54	Progressive microcephaly (HP:0000253)	2.09590724
55	Status epilepticus (HP:0002133)	2.09438082
56	Abnormality of the renal medulla (HP:0100957)	2.08557771
57	Congenital, generalized hypertrichosis (HP:0004540)	2.08050110
58	3-Methylglutaconic aciduria (HP:0003535)	2.03459368
59	Increased corneal curvature (HP:0100692)	2.01535693
60	Keratoconus (HP:0000563)	2.01535693
61	Retinitis pigmentosa (HP:0000510)	1.99999767
62	Tubulointerstitial abnormality (HP:0001969)	1.99730371
63	Cone-rod dystrophy (HP:0000548)	1.98060773
64	Pancreatic fibrosis (HP:0100732)	1.97162139
65	Nephrogenic diabetes insipidus (HP:0009806)	1.96920903
66	True hermaphroditism (HP:0010459)	1.95919359
67	Renal cortical cysts (HP:0000803)	1.94911931
68	Acute lymphatic leukemia (HP:0006721)	1.90494681
69	Action tremor (HP:0002345)	1.89833065
70	Focal seizures (HP:0007359)	1.88710457
71	Congenital stationary night blindness (HP:0007642)	1.88660032
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.87929657
73	Synostosis involving the elbow (HP:0003938)	1.87740252
74	Humeroradial synostosis (HP:0003041)	1.87740252
75	Sex reversal (HP:0012245)	1.86366861
76	Abnormal sex determination (HP:0012244)	1.86366861
77	Increased cerebral lipofuscin (HP:0011813)	1.86347425
78	Hypoproteinemia (HP:0003075)	1.86241605
79	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.85792579
80	Gonadotropin excess (HP:0000837)	1.84772442
81	Type I transferrin isoform profile (HP:0003642)	1.84500879
82	Decreased testicular size (HP:0008734)	1.83907800
83	Impaired vibratory sensation (HP:0002495)	1.83638626
84	Progressive visual loss (HP:0000529)	1.82515880
85	Impaired vibration sensation in the lower limbs (HP:0002166)	1.80856302
86	Zonular cataract (HP:0010920)	1.80462608
87	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.76865693
88	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.75139553
89	Abnormality of the renal cortex (HP:0011035)	1.72964633
90	Genital tract atresia (HP:0001827)	1.72498373
91	Congenital hepatic fibrosis (HP:0002612)	1.68948306
92	Abnormal pupillary function (HP:0007686)	1.63994632
93	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.63959331
94	Vaginal atresia (HP:0000148)	1.63202663
95	Rectal fistula (HP:0100590)	1.62885497
96	Rectovaginal fistula (HP:0000143)	1.62885497
97	Hepatocellular necrosis (HP:0001404)	1.62869873
98	Dyskinesia (HP:0100660)	1.62833258
99	Acute myeloid leukemia (HP:0004808)	1.61006212
100	Dysdiadochokinesis (HP:0002075)	1.60857962

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	4.77148902
2	WNK3	4.35227188
3	PIK3CG	4.18942868
4	NUAK1	3.59663631
5	FRK	3.22876158
6	KIT	3.21557544
7	MAP4K2	2.91487922
8	CCNB1	2.81631293
9	FLT3	2.57905227
10	CSF1R	2.31180353
11	TEC	1.99387507
12	BMPR1B	1.85277691
13	PLK4	1.80044300
14	PTK2B	1.79009418
15	BCKDK	1.77749139
16	GRK5	1.63339704
17	IRAK1	1.54015089
18	NEK2	1.41992999
19	MARK1	1.41055196
20	GRK7	1.39038483
21	ADRBK2	1.38984059
22	JAK3	1.33144806
23	SIK2	1.32661942
24	TAOK3	1.32420999
25	PLK2	1.29278477
26	MAP4K1	1.28951648
27	DAPK1	1.26265488
28	GRK1	1.25832134
29	MKNK1	1.25107815
30	MAP3K10	1.15744102
31	MKNK2	1.08412741
32	STK3	1.07036841
33	NTRK3	1.04743079
34	SYK	1.03433789
35	ADRBK1	1.01609122
36	DAPK2	0.99661842
37	OXSR1	0.99247504
38	MAP3K12	0.96339809
39	PHKG2	0.92626265
40	PHKG1	0.92626265
41	ITK	0.92477263
42	LATS1	0.92433822
43	ACVR1B	0.89357351
44	PKN1	0.86913357
45	RAF1	0.85360207
46	CDK19	0.85103768
47	PRKCE	0.82922194
48	LYN	0.78590724
49	TXK	0.78091047
50	DYRK1A	0.67109871
51	MAP2K2	0.66860097
52	MAPK13	0.64176067
53	STK38L	0.63118257
54	ILK	0.61892364
55	MAP3K4	0.59557358
56	MINK1	0.57171364
57	STK39	0.55739972
58	TAF1	0.54134028
59	CDK3	0.54090306
60	CDC7	0.52211104
61	PRKAA1	0.51982553
62	IKBKE	0.51638348
63	MAP2K7	0.49899381
64	PRKCG	0.49691879
65	PRKCH	0.49459161
66	EPHA4	0.49162892
67	ABL1	0.48791666
68	TLK1	0.48669258
69	IKBKB	0.47179170
70	MYLK	0.46602971
71	PRKG1	0.46572784
72	CAMK1	0.45980176
73	DYRK2	0.45684632
74	VRK2	0.45114318
75	MAPK7	0.44256997
76	LCK	0.41102761
77	VRK1	0.40391273
78	CAMK2A	0.40041635
79	CHEK2	0.39837386
80	BLK	0.39693433
81	CAMK1G	0.39272571
82	STK4	0.39055219
83	CSNK1D	0.38907696
84	BTK	0.38539980
85	PIM2	0.38514337
86	CSNK1A1	0.38055334
87	CAMK2D	0.36976793
88	GSK3A	0.35466657
89	PRKACA	0.33418508
90	BRD4	0.33043917
91	FYN	0.32798346
92	NEK1	0.32260447
93	SIK3	0.32214266
94	CDK6	0.31961268
95	GRK6	0.31599632
96	MAPK4	0.31440669
97	DYRK3	0.31255535
98	MAPKAPK3	0.31238081
99	PRKCB	0.30665560
100	PINK1	0.30209441

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.21902469
2	Regulation of autophagy_Homo sapiens_hsa04140	3.15074025
3	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	3.06526210
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.80216113
5	Phototransduction_Homo sapiens_hsa04744	2.77612798
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.65116171
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.45508736
8	Olfactory transduction_Homo sapiens_hsa04740	2.32057468
9	Protein export_Homo sapiens_hsa03060	2.16086937
10	Nicotine addiction_Homo sapiens_hsa05033	2.14399915
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.06072912
12	Morphine addiction_Homo sapiens_hsa05032	1.95942583
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.88368689
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86027934
15	Allograft rejection_Homo sapiens_hsa05330	1.82009920
16	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.78436420
17	GABAergic synapse_Homo sapiens_hsa04727	1.76517016
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.75096798
19	Taste transduction_Homo sapiens_hsa04742	1.59161216
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.52270268
21	Homologous recombination_Homo sapiens_hsa03440	1.47866285
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.43622501
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.40122391
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.40117019
25	Circadian entrainment_Homo sapiens_hsa04713	1.39671846
26	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.31706798
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.31559660
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.30124033
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.28738063
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.27465116
31	Butanoate metabolism_Homo sapiens_hsa00650	1.22076804
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20134427
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.18640103
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.17193352
35	Serotonergic synapse_Homo sapiens_hsa04726	1.16755310
36	Legionellosis_Homo sapiens_hsa05134	1.14623496
37	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.12334036
38	Rheumatoid arthritis_Homo sapiens_hsa05323	1.09554293
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.07162179
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.07117144
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.04536357
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04314603
43	Collecting duct acid secretion_Homo sapiens_hsa04966	1.00731839
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.98237477
45	Salivary secretion_Homo sapiens_hsa04970	0.97427052
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.94150309
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94091757
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.91226548
49	Calcium signaling pathway_Homo sapiens_hsa04020	0.91114644
50	Fatty acid degradation_Homo sapiens_hsa00071	0.89229557
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.87820663
52	RNA degradation_Homo sapiens_hsa03018	0.86564309
53	Retinol metabolism_Homo sapiens_hsa00830	0.85092585
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84468143
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.78267134
56	Cholinergic synapse_Homo sapiens_hsa04725	0.77702843
57	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.76853966
58	Amphetamine addiction_Homo sapiens_hsa05031	0.76501891
59	Peroxisome_Homo sapiens_hsa04146	0.76247923
60	Leishmaniasis_Homo sapiens_hsa05140	0.76127726
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75543691
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.74182478
63	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.73376143
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.72338851
65	Histidine metabolism_Homo sapiens_hsa00340	0.72302200
66	Fatty acid elongation_Homo sapiens_hsa00062	0.70198567
67	Insulin secretion_Homo sapiens_hsa04911	0.68679605
68	Spliceosome_Homo sapiens_hsa03040	0.67838500
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.66233060
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64980935
71	African trypanosomiasis_Homo sapiens_hsa05143	0.64182339
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.62144440
73	Oxidative phosphorylation_Homo sapiens_hsa00190	0.60154693
74	Purine metabolism_Homo sapiens_hsa00230	0.60128583
75	RNA polymerase_Homo sapiens_hsa03020	0.59147498
76	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.58518964
77	Long-term depression_Homo sapiens_hsa04730	0.56888553
78	Gastric acid secretion_Homo sapiens_hsa04971	0.54539218
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.54348410
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53268348
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.52423123
82	Alcoholism_Homo sapiens_hsa05034	0.51838528
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.51127029
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49775580
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48033653
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.47960883
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47430461
88	Nucleotide excision repair_Homo sapiens_hsa03420	0.46479948
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44212661
90	Tuberculosis_Homo sapiens_hsa05152	0.43453509
91	Basal transcription factors_Homo sapiens_hsa03022	0.40447865
92	RNA transport_Homo sapiens_hsa03013	0.40157977
93	Platelet activation_Homo sapiens_hsa04611	0.39229616
94	Renin secretion_Homo sapiens_hsa04924	0.35938913
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34981480
96	Glutathione metabolism_Homo sapiens_hsa00480	0.32412016
97	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.32292919
98	Long-term potentiation_Homo sapiens_hsa04720	0.32129455
99	Mismatch repair_Homo sapiens_hsa03430	0.31422140
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.31001554

CNTNAP3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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