ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	heparin metabolic process (GO:0030202)	8.40354510
2	heparin biosynthetic process (GO:0030210)	8.40354510
3	detection of light stimulus involved in sensory perception (GO:0050962)	5.84202468
4	detection of light stimulus involved in visual perception (GO:0050908)	5.84202468
5	leukotriene biosynthetic process (GO:0019370)	5.46176788
6	neuronal action potential propagation (GO:0019227)	5.02958581
7	cell wall macromolecule catabolic process (GO:0016998)	4.80627274
8	neurotransmitter-gated ion channel clustering (GO:0072578)	4.67260452
9	response to pheromone (GO:0019236)	4.46984679
10	translesion synthesis (GO:0019985)	4.37762866
11	protein prenylation (GO:0018342)	4.37176691
12	prenylation (GO:0097354)	4.37176691
13	exocrine pancreas development (GO:0031017)	4.33173833
14	gamma-aminobutyric acid transport (GO:0015812)	4.05539455
15	cellular response to interleukin-15 (GO:0071350)	4.01699126
16	cell wall macromolecule metabolic process (GO:0044036)	3.99906595
17	viral mRNA export from host cell nucleus (GO:0046784)	3.94484664
18	positive regulation of cAMP-mediated signaling (GO:0043950)	3.93363323
19	cellular ketone body metabolic process (GO:0046950)	3.87543756
20	Sertoli cell development (GO:0060009)	3.72584333
21	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.71321759
22	regulation of cardiac muscle cell contraction (GO:0086004)	3.63519786
23	interkinetic nuclear migration (GO:0022027)	3.54577338
24	regulation of sarcomere organization (GO:0060297)	3.50545848
25	ketone body metabolic process (GO:1902224)	3.41857561
26	photoreceptor cell maintenance (GO:0045494)	3.33646343
27	leukotriene metabolic process (GO:0006691)	3.30553426
28	regulation of actin filament-based movement (GO:1903115)	3.28123155
29	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.23500628
30	regulation of translation, ncRNA-mediated (GO:0045974)	3.23500628
31	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.23500628
32	kidney morphogenesis (GO:0060993)	3.19945547
33	interferon-gamma secretion (GO:0072643)	3.15693577
34	replication fork processing (GO:0031297)	3.11184537
35	icosanoid biosynthetic process (GO:0046456)	3.08891744
36	fatty acid derivative biosynthetic process (GO:1901570)	3.08891744
37	positive regulation of cardiac muscle cell differentiation (GO:2000727)	3.08809384
38	negative regulation of cAMP-mediated signaling (GO:0043951)	3.01863187
39	response to folic acid (GO:0051593)	3.01692492
40	positive T cell selection (GO:0043368)	3.01571647
41	regulation of voltage-gated calcium channel activity (GO:1901385)	3.01489567
42	presynaptic membrane organization (GO:0097090)	3.00166002
43	negative regulation of protein oligomerization (GO:0032460)	3.00138677
44	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.98959113
45	presynaptic membrane assembly (GO:0097105)	2.97017507
46	protein heterotetramerization (GO:0051290)	2.93267748
47	cerebral cortex radially oriented cell migration (GO:0021799)	2.90769163
48	keratinocyte development (GO:0003334)	2.90125231
49	cAMP catabolic process (GO:0006198)	2.87327183
50	positive regulation of interleukin-17 production (GO:0032740)	2.85076207
51	dentate gyrus development (GO:0021542)	2.84781392
52	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.82673388
53	protein sumoylation (GO:0016925)	2.82010853
54	cyclic nucleotide catabolic process (GO:0009214)	2.81597526
55	coenzyme catabolic process (GO:0009109)	2.79904390
56	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	2.79782360
57	positive regulation of muscle hypertrophy (GO:0014742)	2.78380532
58	positive regulation of cardiac muscle hypertrophy (GO:0010613)	2.78380532
59	heme transport (GO:0015886)	2.75646275
60	reciprocal meiotic recombination (GO:0007131)	2.75623779
61	reciprocal DNA recombination (GO:0035825)	2.75623779
62	response to interleukin-15 (GO:0070672)	2.73207395
63	glutamate receptor signaling pathway (GO:0007215)	2.70527429
64	platelet dense granule organization (GO:0060155)	2.68845168
65	neural tube formation (GO:0001841)	2.66850842
66	mitotic cell cycle arrest (GO:0071850)	2.65323700
67	one-carbon compound transport (GO:0019755)	2.64865013
68	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.60410278
69	cytolysis (GO:0019835)	2.60348423
70	negative regulation of neurotransmitter transport (GO:0051589)	2.59618095
71	dopamine transport (GO:0015872)	2.59004308
72	regulation of timing of cell differentiation (GO:0048505)	2.57943040
73	retinal cone cell development (GO:0046549)	2.56484589
74	adenosine metabolic process (GO:0046085)	2.56179839
75	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.54437076
76	neuronal action potential (GO:0019228)	2.46857272
77	tryptophan catabolic process (GO:0006569)	2.44397075
78	indole-containing compound catabolic process (GO:0042436)	2.44397075
79	indolalkylamine catabolic process (GO:0046218)	2.44397075
80	sialylation (GO:0097503)	2.43471034
81	serotonin metabolic process (GO:0042428)	2.41958595
82	negative regulation of astrocyte differentiation (GO:0048712)	2.41391171
83	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.41380843
84	lens development in camera-type eye (GO:0002088)	2.39331094
85	cornea development in camera-type eye (GO:0061303)	2.39223261
86	activated T cell proliferation (GO:0050798)	2.39072832
87	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.37689738
88	regulation of protein glycosylation (GO:0060049)	2.37541793
89	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.37211309
90	inner ear receptor stereocilium organization (GO:0060122)	2.36838943
91	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.35383024
92	regulation of B cell receptor signaling pathway (GO:0050855)	2.33689507
93	regulation of cAMP-mediated signaling (GO:0043949)	2.33190466
94	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.32939552
95	negative regulation of adaptive immune response (GO:0002820)	2.32114028
96	unsaturated fatty acid biosynthetic process (GO:0006636)	2.31986109
97	male sex determination (GO:0030238)	2.29483955
98	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.28803359
99	specification of organ identity (GO:0010092)	2.28461690
100	visual perception (GO:0007601)	2.28458018

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.59781930
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.01623715
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.82364336
4	VDR_22108803_ChIP-Seq_LS180_Human	3.12892963
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.92695502
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.91752666
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.86427288
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71470717
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.70573864
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.53614721
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53315368
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52737666
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.32666007
14	EWS_26573619_Chip-Seq_HEK293_Human	2.26804373
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25441314
16	P300_19829295_ChIP-Seq_ESCs_Human	2.13234460
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.12215225
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.05674702
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.03094975
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.93589317
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.92375177
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91688449
23	FUS_26573619_Chip-Seq_HEK293_Human	1.85556157
24	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.77914263
25	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.75780214
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.75644690
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.71684369
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69569349
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.67299507
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63439007
31	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.62430075
32	STAT3_23295773_ChIP-Seq_U87_Human	1.59556910
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.57348868
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57094563
35	TCF4_23295773_ChIP-Seq_U87_Human	1.56686016
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55231098
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54169731
38	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.53434202
39	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.52428508
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51719547
41	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49456295
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44184222
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43552157
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43552157
45	AR_25329375_ChIP-Seq_VCAP_Human	1.42838106
46	KDM2B_26808549_Chip-Seq_REH_Human	1.40875118
47	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.39592641
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.36185777
49	DROSHA_22980978_ChIP-Seq_HELA_Human	1.33052355
50	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.31390847
51	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.31214836
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30936673
53	EGR1_19032775_ChIP-ChIP_M12_Human	1.30711015
54	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.30467654
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29381937
56	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29351296
57	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.28412391
58	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.26797179
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.25736981
60	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25373816
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23867115
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.23867115
63	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.23167318
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22544299
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22511591
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.19710575
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18046612
68	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.17133031
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16655053
70	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.14864276
71	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12200883
72	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10828612
73	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10694631
74	TCF4_22108803_ChIP-Seq_LS180_Human	1.10232385
75	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09904143
76	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09427200
77	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.09027932
78	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08949373
79	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.08398061
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.08160051
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07868613
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05558527
83	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04823656
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04821397
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04775432
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04775432
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04133097
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04133097
89	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03013128
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.02871883
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02571843
92	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.00977667
93	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00129927
94	P300_18555785_Chip-Seq_ESCs_Mouse	0.99572872
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.98998626
96	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.98002878
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97543087
98	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.97471611
99	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.97444614
100	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97315821

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002009_preneoplasia	4.75780973
2	MP0003880_abnormal_central_pattern	3.56731840
3	MP0003878_abnormal_ear_physiology	3.20770087
4	MP0005377_hearing/vestibular/ear_phenot	3.20770087
5	MP0005645_abnormal_hypothalamus_physiol	3.04711342
6	MP0002736_abnormal_nociception_after	2.71780182
7	MP0003183_abnormal_peptide_metabolism	2.65211452
8	MP0009697_abnormal_copulation	2.61502354
9	MP0002102_abnormal_ear_morphology	2.60264893
10	MP0008877_abnormal_DNA_methylation	2.36913783
11	MP0005551_abnormal_eye_electrophysiolog	2.36466691
12	MP0002822_catalepsy	2.27196743
13	MP0001968_abnormal_touch/_nociception	2.22621925
14	MP0002166_altered_tumor_susceptibility	2.12302871
15	MP0002909_abnormal_adrenal_gland	2.04943545
16	MP0009046_muscle_twitch	1.90797867
17	MP0002163_abnormal_gland_morphology	1.84251480
18	MP0002638_abnormal_pupillary_reflex	1.79898720
19	MP0008872_abnormal_physiological_respon	1.76555062
20	MP0004043_abnormal_pH_regulation	1.67976452
21	MP0004147_increased_porphyrin_level	1.66765352
22	MP0002735_abnormal_chemical_nociception	1.62499876
23	MP0009745_abnormal_behavioral_response	1.60306633
24	MP0008789_abnormal_olfactory_epithelium	1.57944366
25	MP0000631_abnormal_neuroendocrine_gland	1.55160905
26	MP0005671_abnormal_response_to	1.54380281
27	MP0004142_abnormal_muscle_tone	1.53525457
28	MP0005647_abnormal_sex_gland	1.48074722
29	MP0005423_abnormal_somatic_nervous	1.47088116
30	MP0005646_abnormal_pituitary_gland	1.46907384
31	MP0001486_abnormal_startle_reflex	1.46878995
32	MP0004215_abnormal_myocardial_fiber	1.46405060
33	MP0002006_tumorigenesis	1.45170214
34	MP0006072_abnormal_retinal_apoptosis	1.43799066
35	MP0001984_abnormal_olfaction	1.40505583
36	MP0001756_abnormal_urination	1.38309874
37	MP0002272_abnormal_nervous_system	1.38100411
38	MP0002837_dystrophic_cardiac_calcinosis	1.37916873
39	MP0006036_abnormal_mitochondrial_physio	1.37704545
40	MP0008260_abnormal_autophagy	1.35609993
41	MP0006035_abnormal_mitochondrial_morpho	1.34879494
42	MP0005379_endocrine/exocrine_gland_phen	1.31287810
43	MP0005253_abnormal_eye_physiology	1.30431291
44	MP0003787_abnormal_imprinting	1.26487401
45	MP0000427_abnormal_hair_cycle	1.24239907
46	MP0005386_behavior/neurological_phenoty	1.22104078
47	MP0004924_abnormal_behavior	1.22104078
48	MP0001529_abnormal_vocalization	1.21116288
49	MP0002332_abnormal_exercise_endurance	1.18402842
50	MP0002067_abnormal_sensory_capabilities	1.18301046
51	MP0008569_lethality_at_weaning	1.10252607
52	MP0003045_fibrosis	1.09427094
53	MP0002064_seizures	1.07271766
54	MP0002693_abnormal_pancreas_physiology	1.06861252
55	MP0001440_abnormal_grooming_behavior	1.06769938
56	MP0000465_gastrointestinal_hemorrhage	1.04384002
57	MP0005499_abnormal_olfactory_system	1.01300537
58	MP0005394_taste/olfaction_phenotype	1.01300537
59	MP0002572_abnormal_emotion/affect_behav	1.00117115
60	MP0001835_abnormal_antigen_presentation	0.99154030
61	MP0004859_abnormal_synaptic_plasticity	0.98968152
62	MP0001485_abnormal_pinna_reflex	0.98085147
63	MP0006276_abnormal_autonomic_nervous	0.97757754
64	MP0003195_calcinosis	0.95917008
65	MP0003635_abnormal_synaptic_transmissio	0.95368304
66	MP0010368_abnormal_lymphatic_system	0.94597365
67	MP0001873_stomach_inflammation	0.93382031
68	MP0003137_abnormal_impulse_conducting	0.89096795
69	MP0009764_decreased_sensitivity_to	0.87471595
70	MP0003121_genomic_imprinting	0.86628102
71	MP0001661_extended_life_span	0.85972581
72	MP0002078_abnormal_glucose_homeostasis	0.85540057
73	MP0006082_CNS_inflammation	0.84728337
74	MP0000230_abnormal_systemic_arterial	0.84722706
75	MP0000026_abnormal_inner_ear	0.83902727
76	MP0004885_abnormal_endolymph	0.83100722
77	MP0001502_abnormal_circadian_rhythm	0.82740575
78	MP0005367_renal/urinary_system_phenotyp	0.81851741
79	MP0000516_abnormal_urinary_system	0.81851741
80	MP0005448_abnormal_energy_balance	0.80856248
81	MP0010386_abnormal_urinary_bladder	0.80536471
82	MP0009115_abnormal_fat_cell	0.80322631
83	MP0005334_abnormal_fat_pad	0.79620690
84	MP0002229_neurodegeneration	0.78940636
85	MP0006138_congestive_heart_failure	0.78909644
86	MP0001544_abnormal_cardiovascular_syste	0.74220307
87	MP0005385_cardiovascular_system_phenoty	0.74220307
88	MP0001970_abnormal_pain_threshold	0.72387997
89	MP0002557_abnormal_social/conspecific_i	0.71660246
90	MP0005410_abnormal_fertilization	0.71320751
91	MP0004130_abnormal_muscle_cell	0.71254866
92	MP0001986_abnormal_taste_sensitivity	0.71178461
93	MP0004145_abnormal_muscle_electrophysio	0.70724569
94	MP0003879_abnormal_hair_cell	0.69618324
95	MP0003698_abnormal_male_reproductive	0.69288947
96	MP0002063_abnormal_learning/memory/cond	0.68858280
97	MP0002752_abnormal_somatic_nervous	0.68449989
98	MP0004019_abnormal_vitamin_homeostasis	0.67866017
99	MP0004134_abnormal_chest_morphology	0.67550744
100	MP0002168_other_aberrant_phenotype	0.67432049

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	5.17182178
2	Abolished electroretinogram (ERG) (HP:0000550)	4.48278475
3	Hypoplastic nipples (HP:0002557)	3.91259668
4	Bilateral sensorineural hearing impairment (HP:0008619)	3.69625703
5	Hyperventilation (HP:0002883)	3.57409270
6	Ketoacidosis (HP:0001993)	3.52591153
7	Enlarged penis (HP:0000040)	3.47266694
8	Gaze-evoked nystagmus (HP:0000640)	3.42691305
9	Congenital stationary night blindness (HP:0007642)	3.24914461
10	Dyskinesia (HP:0100660)	3.16069309
11	Febrile seizures (HP:0002373)	3.13124625
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.12886375
13	Palpebral edema (HP:0100540)	3.12113669
14	Wide intermamillary distance (HP:0006610)	3.12092031
15	Attenuation of retinal blood vessels (HP:0007843)	2.97082779
16	Pancreatic islet-cell hyperplasia (HP:0004510)	2.94509044
17	Inability to walk (HP:0002540)	2.78175151
18	Optic neuritis (HP:0100653)	2.73124748
19	Retrobulbar optic neuritis (HP:0100654)	2.73124748
20	Medial flaring of the eyebrow (HP:0010747)	2.72564701
21	Bony spicule pigmentary retinopathy (HP:0007737)	2.71756219
22	Hypoglycemic coma (HP:0001325)	2.69043610
23	J-shaped sella turcica (HP:0002680)	2.63763449
24	Amyotrophic lateral sclerosis (HP:0007354)	2.62226865
25	Broad-based gait (HP:0002136)	2.59487304
26	Fair hair (HP:0002286)	2.59011228
27	Congenital sensorineural hearing impairment (HP:0008527)	2.55503895
28	Abnormality of alanine metabolism (HP:0010916)	2.49551448
29	Hyperalaninemia (HP:0003348)	2.49551448
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.49551448
31	Ketosis (HP:0001946)	2.45862287
32	Gonadotropin excess (HP:0000837)	2.39144024
33	Short chin (HP:0000331)	2.33978164
34	Progressive inability to walk (HP:0002505)	2.32846534
35	Renal hypoplasia (HP:0000089)	2.28324722
36	Hypoglycemic seizures (HP:0002173)	2.25063693
37	Hypoproteinemia (HP:0003075)	2.23486383
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23481324
39	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.20863955
40	Hypoplasia of the fovea (HP:0007750)	2.20863955
41	Rib fusion (HP:0000902)	2.20590833
42	Orchitis (HP:0100796)	2.18522646
43	Hyperglycemia (HP:0003074)	2.18366843
44	Panhypogammaglobulinemia (HP:0003139)	2.18065186
45	Myositis (HP:0100614)	2.14160975
46	Gait imbalance (HP:0002141)	2.10388999
47	Choroideremia (HP:0001139)	2.10208040
48	Retinal dysplasia (HP:0007973)	2.09641288
49	Reduced subcutaneous adipose tissue (HP:0003758)	2.08986017
50	Hemiplegia (HP:0002301)	2.07883935
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.07874451
52	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07874451
53	Scotoma (HP:0000575)	2.07546734
54	Abnormality of DNA repair (HP:0003254)	2.04744802
55	Tented upper lip vermilion (HP:0010804)	2.03574198
56	Abnormal ciliary motility (HP:0012262)	2.02977967
57	Absent speech (HP:0001344)	2.02622074
58	Tinnitus (HP:0000360)	2.02545315
59	Congenital primary aphakia (HP:0007707)	2.02356626
60	Abnormality of the renal cortex (HP:0011035)	2.01931899
61	Elevated erythrocyte sedimentation rate (HP:0003565)	2.00422017
62	Zonular cataract (HP:0010920)	1.99514689
63	Abnormality of macular pigmentation (HP:0008002)	1.97947445
64	Abnormality of endocrine pancreas physiology (HP:0012093)	1.93065527
65	Abnormality of the pancreatic islet cells (HP:0006476)	1.93065527
66	Encephalitis (HP:0002383)	1.92484467
67	Syncope (HP:0001279)	1.91377461
68	Abnormality of the metopic suture (HP:0005556)	1.90464346
69	Decreased central vision (HP:0007663)	1.89295831
70	Microretrognathia (HP:0000308)	1.89268362
71	Abnormal drinking behavior (HP:0030082)	1.86761219
72	Polydipsia (HP:0001959)	1.86761219
73	Generalized hypopigmentation of hair (HP:0011358)	1.85588065
74	Hemiparesis (HP:0001269)	1.84846463
75	Progressive microcephaly (HP:0000253)	1.83754514
76	Pancytopenia (HP:0001876)	1.83670227
77	Keratoconjunctivitis (HP:0001096)	1.83544120
78	Calf muscle hypertrophy (HP:0008981)	1.79223699
79	Nephrogenic diabetes insipidus (HP:0009806)	1.78877239
80	Absent/shortened dynein arms (HP:0200106)	1.78856671
81	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78856671
82	Genital tract atresia (HP:0001827)	1.78388020
83	Acanthocytosis (HP:0001927)	1.78349882
84	Bulbous nose (HP:0000414)	1.77942728
85	Pheochromocytoma (HP:0002666)	1.75914443
86	Keratoconjunctivitis sicca (HP:0001097)	1.74700355
87	Bifid scrotum (HP:0000048)	1.72845965
88	Joint hemorrhage (HP:0005261)	1.72301495
89	Chronic mucocutaneous candidiasis (HP:0002728)	1.72224653
90	Recurrent cutaneous fungal infections (HP:0011370)	1.72224653
91	Central scotoma (HP:0000603)	1.71316450
92	Abnormality of the fovea (HP:0000493)	1.70552179
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69843225
94	Abnormality of midbrain morphology (HP:0002418)	1.69629020
95	Molar tooth sign on MRI (HP:0002419)	1.69629020
96	Widely spaced teeth (HP:0000687)	1.69527754
97	Vaginal atresia (HP:0000148)	1.69297829
98	Astigmatism (HP:0000483)	1.67190792
99	Poor eye contact (HP:0000817)	1.66751392
100	Genetic anticipation (HP:0003743)	1.66667071

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	6.44103383
2	WNK3	5.42535020
3	FRK	4.46011759
4	NUAK1	2.92577360
5	PIK3CG	2.84980380
6	PTK2B	2.04767898
7	KIT	1.71506993
8	FLT3	1.71430822
9	ACVR1B	1.69403810
10	CCNB1	1.69371629
11	WNK4	1.65970984
12	MAP3K4	1.65663140
13	MAP4K2	1.60740765
14	STK39	1.57377662
15	MARK1	1.56924493
16	MKNK2	1.44456694
17	OXSR1	1.43463118
18	MAP2K7	1.39512727
19	LATS1	1.39201146
20	KDR	1.38170595
21	UHMK1	1.30166000
22	ADRBK2	1.27247112
23	TNIK	1.26238235
24	CSF1R	1.23402029
25	GRK1	1.18166107
26	BMPR1B	1.17448800
27	DAPK1	1.12112103
28	BCKDK	1.10495789
29	MAP3K10	1.07674916
30	JAK3	1.06452743
31	CSNK1G2	0.99359671
32	MAPK13	0.97763402
33	BLK	0.96090672
34	MAP4K1	0.95509438
35	GRK5	0.94003613
36	AKT3	0.93931434
37	DAPK2	0.93026653
38	GRK7	0.90610102
39	PHKG2	0.90289236
40	PHKG1	0.90289236
41	VRK1	0.89919480
42	MKNK1	0.88979322
43	MYLK	0.88889701
44	MAPKAPK3	0.88507820
45	OBSCN	0.86735860
46	TAOK3	0.85343429
47	PINK1	0.85173424
48	HIPK2	0.85033124
49	STK3	0.84796597
50	PRKCE	0.84793121
51	IRAK1	0.84772950
52	LYN	0.78673884
53	CAMKK2	0.76195974
54	ADRBK1	0.75209945
55	PNCK	0.74835030
56	MAP3K6	0.74179612
57	PKN1	0.72041586
58	CAMK1G	0.70768248
59	NTRK2	0.70199394
60	CAMK2A	0.64110461
61	SGK2	0.62964246
62	SYK	0.62863448
63	CSNK1D	0.60433164
64	NTRK3	0.60026439
65	SIK2	0.59668523
66	PRKCH	0.58491489
67	TAF1	0.57438077
68	YES1	0.57090167
69	LCK	0.55725758
70	TXK	0.53520029
71	TGFBR1	0.53295222
72	CSNK1G1	0.53221094
73	PLK2	0.52293020
74	TIE1	0.51706068
75	EPHA4	0.51191144
76	EPHA3	0.51180675
77	TEC	0.49767465
78	PRKCQ	0.49313566
79	CSNK1G3	0.48422000
80	CAMK1	0.46912117
81	PRKG1	0.46196074
82	DYRK2	0.44272089
83	DYRK1A	0.44121835
84	MAP3K12	0.43457683
85	ROCK1	0.41828039
86	FGFR2	0.41435024
87	CAMK4	0.41141005
88	PRKCG	0.38919605
89	ZAK	0.38292309
90	CDK19	0.37285787
91	PRKACA	0.37237728
92	RPS6KA6	0.36801550
93	SGK494	0.36441329
94	SGK223	0.36441329
95	STK11	0.36153811
96	PRKD1	0.34565515
97	DYRK1B	0.34002012
98	PRKAA1	0.33438582
99	CDK5	0.32250615
100	BTK	0.30951744

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Regulation of autophagy_Homo sapiens_hsa04140	3.27431278
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.89746055
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.60470088
4	Phototransduction_Homo sapiens_hsa04744	2.54584265
5	Olfactory transduction_Homo sapiens_hsa04740	2.39803630
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.20881380
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.12874209
8	Glutamatergic synapse_Homo sapiens_hsa04724	1.97935730
9	Amphetamine addiction_Homo sapiens_hsa05031	1.93913680
10	Renin secretion_Homo sapiens_hsa04924	1.91062398
11	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.89931821
12	Asthma_Homo sapiens_hsa05310	1.84420628
13	Taste transduction_Homo sapiens_hsa04742	1.83280708
14	Nicotine addiction_Homo sapiens_hsa05033	1.72907262
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70175017
16	Protein export_Homo sapiens_hsa03060	1.69907729
17	Morphine addiction_Homo sapiens_hsa05032	1.68802945
18	Butanoate metabolism_Homo sapiens_hsa00650	1.68247489
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62156423
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.62148786
21	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.46363788
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.46055252
23	GABAergic synapse_Homo sapiens_hsa04727	1.45377139
24	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.37947776
25	Circadian entrainment_Homo sapiens_hsa04713	1.37878233
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37608434
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32652076
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30473157
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.26749944
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.25615890
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.25452945
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24389406
33	Circadian rhythm_Homo sapiens_hsa04710	1.24288968
34	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.20895350
35	Calcium signaling pathway_Homo sapiens_hsa04020	1.19689866
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.18512448
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.17135912
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.16565677
39	Insulin secretion_Homo sapiens_hsa04911	1.13263687
40	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.12308130
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12159543
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06085714
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.06080977
44	Homologous recombination_Homo sapiens_hsa03440	1.05224116
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.05112532
46	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.03890304
47	One carbon pool by folate_Homo sapiens_hsa00670	1.02985810
48	Salivary secretion_Homo sapiens_hsa04970	1.02700145
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.00335951
50	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.98798591
51	Propanoate metabolism_Homo sapiens_hsa00640	0.98162741
52	Serotonergic synapse_Homo sapiens_hsa04726	0.97042734
53	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.96853352
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95203957
55	Sulfur relay system_Homo sapiens_hsa04122	0.94903212
56	Allograft rejection_Homo sapiens_hsa05330	0.90473446
57	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.90219452
58	Graft-versus-host disease_Homo sapiens_hsa05332	0.88926927
59	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.87357509
60	Retinol metabolism_Homo sapiens_hsa00830	0.85287716
61	Cocaine addiction_Homo sapiens_hsa05030	0.85101317
62	Peroxisome_Homo sapiens_hsa04146	0.82326423
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.81455248
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.79256004
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.78886944
66	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.76922725
67	ABC transporters_Homo sapiens_hsa02010	0.74952903
68	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.74299594
69	Fatty acid degradation_Homo sapiens_hsa00071	0.73881271
70	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.72737609
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70946610
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70852914
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69770199
74	Long-term potentiation_Homo sapiens_hsa04720	0.66237369
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64827328
76	Gastric acid secretion_Homo sapiens_hsa04971	0.63876908
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63281219
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.62679058
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62166649
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61541120
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61016243
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.61003889
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59984087
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.59179974
85	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.57267653
86	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.56948526
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56696914
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53661639
89	Legionellosis_Homo sapiens_hsa05134	0.52395007
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51728292
91	Histidine metabolism_Homo sapiens_hsa00340	0.48465730
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45966051
93	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.44865889
94	Pancreatic secretion_Homo sapiens_hsa04972	0.44632013
95	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.40977706
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36549557
97	Oxidative phosphorylation_Homo sapiens_hsa00190	0.34913086
98	Basal transcription factors_Homo sapiens_hsa03022	0.32919598
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.32636814
100	Long-term depression_Homo sapiens_hsa04730	0.30668661

CNTNAP3P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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