CNTNAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory behavior (GO:0031223)5.17641876
2neurotransmitter-gated ion channel clustering (GO:0072578)4.87455907
3startle response (GO:0001964)4.78354758
4presynaptic membrane assembly (GO:0097105)4.67115706
5transmission of nerve impulse (GO:0019226)4.57107586
6righting reflex (GO:0060013)4.54118088
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.49660074
8pyrimidine nucleobase catabolic process (GO:0006208)4.46462507
9neuron cell-cell adhesion (GO:0007158)4.43817375
10mechanosensory behavior (GO:0007638)4.31139867
11neuron-neuron synaptic transmission (GO:0007270)4.28627543
12presynaptic membrane organization (GO:0097090)4.24881957
13neuronal action potential (GO:0019228)4.22628447
14behavioral response to nicotine (GO:0035095)4.22605533
15vocalization behavior (GO:0071625)4.09887597
16synaptic transmission, glutamatergic (GO:0035249)4.06371625
17protein localization to synapse (GO:0035418)4.06299477
18response to auditory stimulus (GO:0010996)4.06226345
19glycosphingolipid biosynthetic process (GO:0006688)4.00895186
20glutamate receptor signaling pathway (GO:0007215)3.96913636
21postsynaptic membrane organization (GO:0001941)3.94699941
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.90131863
23membrane depolarization during action potential (GO:0086010)3.89324945
24detection of light stimulus involved in visual perception (GO:0050908)3.83000869
25detection of light stimulus involved in sensory perception (GO:0050962)3.83000869
26gamma-aminobutyric acid transport (GO:0015812)3.79156731
27dendritic spine morphogenesis (GO:0060997)3.77169892
28negative regulation of dendrite development (GO:2000171)3.74919232
29nucleobase catabolic process (GO:0046113)3.68843102
30negative regulation of cytosolic calcium ion concentration (GO:0051481)3.67427738
31axonal fasciculation (GO:0007413)3.66963923
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65936873
33nonmotile primary cilium assembly (GO:0035058)3.62900493
34response to histamine (GO:0034776)3.62269643
35neuron recognition (GO:0008038)3.60601706
36regulation of synapse structural plasticity (GO:0051823)3.59813140
37synaptic vesicle maturation (GO:0016188)3.59179190
38serotonin metabolic process (GO:0042428)3.52138994
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51466952
40neuronal action potential propagation (GO:0019227)3.50204031
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.45711636
42primary amino compound metabolic process (GO:1901160)3.39601439
43synapse assembly (GO:0007416)3.37899307
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34731196
45dendrite morphogenesis (GO:0048813)3.29468787
46behavioral response to ethanol (GO:0048149)3.25613219
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.24592701
48regulation of female receptivity (GO:0045924)3.24478952
49protein localization to cilium (GO:0061512)3.24419885
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.23069263
51positive regulation of synapse maturation (GO:0090129)3.22677395
52nerve growth factor signaling pathway (GO:0038180)3.21234861
53exploration behavior (GO:0035640)3.19294777
54central nervous system projection neuron axonogenesis (GO:0021952)3.16626820
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16529066
56adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.15365763
57regulation of action potential (GO:0098900)3.12807614
58adult walking behavior (GO:0007628)3.12176042
59synaptic vesicle exocytosis (GO:0016079)3.12158122
60synaptic transmission, dopaminergic (GO:0001963)3.08727503
61membrane depolarization (GO:0051899)3.07094328
62positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.04052320
63short-term memory (GO:0007614)2.99402030
64C4-dicarboxylate transport (GO:0015740)2.99061916
65negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98710233
66response to amphetamine (GO:0001975)2.96907281
67reflex (GO:0060004)2.96882717
68regulation of postsynaptic membrane potential (GO:0060078)2.95178865
69regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93105645
70fat-soluble vitamin catabolic process (GO:0042363)2.92695949
71vitamin catabolic process (GO:0009111)2.92695949
72inner ear receptor stereocilium organization (GO:0060122)2.92190331
73regulation of synaptic transmission, glutamatergic (GO:0051966)2.92177015
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.91694276
75action potential (GO:0001508)2.91018106
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90522206
77adult behavior (GO:0030534)2.89001404
78behavioral response to cocaine (GO:0048148)2.88973449
79regulation of synaptic transmission, GABAergic (GO:0032228)2.83267716
80positive regulation of dendritic spine morphogenesis (GO:0061003)2.82063580
81retinal cone cell development (GO:0046549)2.81114206
82synapse organization (GO:0050808)2.80657385
83prepulse inhibition (GO:0060134)2.78923995
84regulation of synapse maturation (GO:0090128)2.78195631
85neuromuscular synaptic transmission (GO:0007274)2.75991676
86cerebellar granule cell differentiation (GO:0021707)2.73959879
87central nervous system neuron axonogenesis (GO:0021955)2.73278916
88auditory receptor cell stereocilium organization (GO:0060088)2.72516434
89neurofilament cytoskeleton organization (GO:0060052)2.70404757
90long term synaptic depression (GO:0060292)2.69967894
91establishment of mitochondrion localization (GO:0051654)2.69877090
92neurotransmitter secretion (GO:0007269)2.69097285
93regulation of dopamine secretion (GO:0014059)2.66652957
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66490240
95cerebellar Purkinje cell differentiation (GO:0021702)2.65575244
96positive regulation of synapse assembly (GO:0051965)2.63289714
97female mating behavior (GO:0060180)2.62831979
98negative regulation of synaptic transmission (GO:0050805)2.62096261
99retina layer formation (GO:0010842)2.61904448
100cAMP-mediated signaling (GO:0019933)2.60742665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.62911278
2EZH2_22144423_ChIP-Seq_EOC_Human4.43833392
3ZFP57_27257070_Chip-Seq_ESCs_Mouse3.09810963
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.02816422
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.87111351
6IGF1R_20145208_ChIP-Seq_DFB_Human2.69205106
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54806932
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.54527650
9TAF15_26573619_Chip-Seq_HEK293_Human2.52158064
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30746327
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27574599
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.25383887
13REST_21632747_ChIP-Seq_MESCs_Mouse2.23016129
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16352826
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10298960
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06522290
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.06266638
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05550643
19FUS_26573619_Chip-Seq_HEK293_Human2.04460949
20ZNF274_21170338_ChIP-Seq_K562_Hela2.03760448
21* P300_19829295_ChIP-Seq_ESCs_Human2.02866861
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00651176
23* SMAD4_21799915_ChIP-Seq_A2780_Human1.99915158
24* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98838979
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.94059450
26* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85986092
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83955831
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83176211
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.82612026
30VDR_22108803_ChIP-Seq_LS180_Human1.82524928
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.82524497
32* EWS_26573619_Chip-Seq_HEK293_Human1.75459821
33RNF2_27304074_Chip-Seq_NSC_Mouse1.72627087
34* SMAD3_21741376_ChIP-Seq_EPCs_Human1.71409011
35* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68957762
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65430456
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65075486
38* STAT3_23295773_ChIP-Seq_U87_Human1.64493234
39* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61486565
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.60763270
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59543040
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.59241785
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58266087
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58266087
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57969956
46* TCF4_23295773_ChIP-Seq_U87_Human1.56547248
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55095312
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54441753
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53589733
50ER_23166858_ChIP-Seq_MCF-7_Human1.52737848
51* AR_25329375_ChIP-Seq_VCAP_Human1.51650944
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50489457
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48031053
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.45540705
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44108834
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44108834
57* DROSHA_22980978_ChIP-Seq_HELA_Human1.42271104
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.38968728
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36668626
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35967168
61CBP_20019798_ChIP-Seq_JUKART_Human1.35607489
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35607489
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35036022
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34982878
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.34969782
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32471035
67* BCAT_22108803_ChIP-Seq_LS180_Human1.31582331
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28771920
69AR_21572438_ChIP-Seq_LNCaP_Human1.27536831
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26990059
71* RUNX2_22187159_ChIP-Seq_PCA_Human1.25766028
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21663912
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21326911
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.20652038
75* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20248305
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.19867687
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.18865264
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18254730
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17997678
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17864181
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13901733
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13036362
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12838315
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10712032
85* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08207401
86TCF4_22108803_ChIP-Seq_LS180_Human1.07228140
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.06599395
88KDM2B_26808549_Chip-Seq_REH_Human1.05904555
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05151214
90* AR_19668381_ChIP-Seq_PC3_Human1.04541832
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04268637
92JUN_21703547_ChIP-Seq_K562_Human1.03761929
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.03539841
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02874567
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01575915
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01383688
97P53_22387025_ChIP-Seq_ESCs_Mouse1.00966917
98AHR_22903824_ChIP-Seq_MCF-7_Human1.00644458
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98689912
100TP53_22573176_ChIP-Seq_HFKS_Human0.97497939

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.11005775
2MP0004859_abnormal_synaptic_plasticity4.08241517
3MP0002736_abnormal_nociception_after3.79712641
4MP0001968_abnormal_touch/_nociception3.78826811
5MP0003880_abnormal_central_pattern3.46924960
6MP0004270_analgesia3.00501700
7MP0009046_muscle_twitch2.99439653
8MP0006276_abnormal_autonomic_nervous2.97730733
9MP0003635_abnormal_synaptic_transmissio2.82812370
10MP0002272_abnormal_nervous_system2.60467780
11MP0002734_abnormal_mechanical_nocicepti2.58953487
12MP0005423_abnormal_somatic_nervous2.52929800
13MP0002735_abnormal_chemical_nociception2.51793417
14MP0002653_abnormal_ependyma_morphology2.51301472
15MP0009745_abnormal_behavioral_response2.51012185
16MP0001529_abnormal_vocalization2.37748081
17MP0001486_abnormal_startle_reflex2.36905006
18MP0002063_abnormal_learning/memory/cond2.27568898
19MP0002064_seizures2.27521875
20MP0002909_abnormal_adrenal_gland2.20964986
21MP0001984_abnormal_olfaction2.16420646
22MP0002572_abnormal_emotion/affect_behav2.12872056
23MP0003787_abnormal_imprinting2.03556285
24MP0000778_abnormal_nervous_system2.00558547
25MP0004742_abnormal_vestibular_system1.90401112
26MP0002067_abnormal_sensory_capabilities1.90320819
27MP0005646_abnormal_pituitary_gland1.85863841
28MP0001970_abnormal_pain_threshold1.85268021
29MP0003122_maternal_imprinting1.84311764
30MP0002102_abnormal_ear_morphology1.81433082
31MP0001188_hyperpigmentation1.77005023
32MP0002184_abnormal_innervation1.76883377
33MP0005386_behavior/neurological_phenoty1.69699591
34MP0004924_abnormal_behavior1.69699591
35MP0008877_abnormal_DNA_methylation1.65315844
36MP0002557_abnormal_social/conspecific_i1.62232636
37MP0001440_abnormal_grooming_behavior1.60374396
38MP0001501_abnormal_sleep_pattern1.57752699
39MP0002733_abnormal_thermal_nociception1.55196109
40MP0000955_abnormal_spinal_cord1.53501803
41MP0005409_darkened_coat_color1.52995266
42MP0005551_abnormal_eye_electrophysiolog1.52638518
43MP0000569_abnormal_digit_pigmentation1.50929966
44MP0002882_abnormal_neuron_morphology1.43159519
45MP0010386_abnormal_urinary_bladder1.39248548
46MP0002638_abnormal_pupillary_reflex1.35161890
47MP0005645_abnormal_hypothalamus_physiol1.35053661
48MP0000631_abnormal_neuroendocrine_gland1.32089249
49MP0008569_lethality_at_weaning1.30303138
50MP0004811_abnormal_neuron_physiology1.27888126
51MP0003121_genomic_imprinting1.26047818
52MP0003633_abnormal_nervous_system1.20520446
53MP0005253_abnormal_eye_physiology1.15947178
54MP0005187_abnormal_penis_morphology1.12255145
55MP0004043_abnormal_pH_regulation1.12255001
56MP0003879_abnormal_hair_cell1.10496833
57MP0002066_abnormal_motor_capabilities/c1.08455464
58MP0002752_abnormal_somatic_nervous1.04988883
59MP0004142_abnormal_muscle_tone1.03669608
60MP0004885_abnormal_endolymph0.99458686
61MP0001905_abnormal_dopamine_level0.98857318
62MP0002229_neurodegeneration0.98461457
63MP0002152_abnormal_brain_morphology0.97761333
64MP0001485_abnormal_pinna_reflex0.96838763
65MP0008872_abnormal_physiological_respon0.95658698
66MP0001963_abnormal_hearing_physiology0.90241619
67MP0002751_abnormal_autonomic_nervous0.89898338
68MP0006072_abnormal_retinal_apoptosis0.89829281
69MP0003119_abnormal_digestive_system0.89061354
70MP0000026_abnormal_inner_ear0.88633339
71MP0003283_abnormal_digestive_organ0.88408134
72MP0001502_abnormal_circadian_rhythm0.86063245
73MP0003195_calcinosis0.84870744
74MP0003631_nervous_system_phenotype0.82736859
75MP0002837_dystrophic_cardiac_calcinosis0.82595065
76MP0004133_heterotaxia0.81678331
77MP0005248_abnormal_Harderian_gland0.81051535
78MP0003137_abnormal_impulse_conducting0.80099495
79MP0005394_taste/olfaction_phenotype0.80040084
80MP0005499_abnormal_olfactory_system0.80040084
81MP0004145_abnormal_muscle_electrophysio0.77778477
82MP0003646_muscle_fatigue0.77008718
83MP0002069_abnormal_eating/drinking_beha0.75062792
84MP0004147_increased_porphyrin_level0.74057328
85MP0003011_delayed_dark_adaptation0.71141907
86MP0004085_abnormal_heartbeat0.69730425
87MP0003890_abnormal_embryonic-extraembry0.67014190
88MP0003861_abnormal_nervous_system0.65237478
89MP0002928_abnormal_bile_duct0.64190495
90MP0005195_abnormal_posterior_eye0.60670885
91MP0000427_abnormal_hair_cycle0.60005499
92MP0006292_abnormal_olfactory_placode0.59282180
93MP0000647_abnormal_sebaceous_gland0.58948228
94MP0002090_abnormal_vision0.54491361
95MP0001986_abnormal_taste_sensitivity0.53350063
96MP0004215_abnormal_myocardial_fiber0.52830023
97MP0008789_abnormal_olfactory_epithelium0.52727518
98MP0000639_abnormal_adrenal_gland0.51658717
99MP0002234_abnormal_pharynx_morphology0.51110479
100MP0010770_preweaning_lethality0.49427773

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.58854916
2Febrile seizures (HP:0002373)5.28264920
3Focal seizures (HP:0007359)4.58945570
4Atonic seizures (HP:0010819)4.39733280
5Epileptic encephalopathy (HP:0200134)4.22881752
6Hyperventilation (HP:0002883)4.15850953
7Myokymia (HP:0002411)4.08437513
8Progressive cerebellar ataxia (HP:0002073)3.85440516
9Dialeptic seizures (HP:0011146)3.43411996
10Action tremor (HP:0002345)3.33631579
11Broad-based gait (HP:0002136)3.28209423
12Gaze-evoked nystagmus (HP:0000640)3.28034473
13Drooling (HP:0002307)3.25211026
14Agitation (HP:0000713)3.25154034
15Absence seizures (HP:0002121)3.21904773
16Gait imbalance (HP:0002141)3.03732723
17Epileptiform EEG discharges (HP:0011182)3.03563292
18Excessive salivation (HP:0003781)2.98598648
19Failure to thrive in infancy (HP:0001531)2.87220942
20EEG with generalized epileptiform discharges (HP:0011198)2.85809701
21Generalized tonic-clonic seizures (HP:0002069)2.85698093
22Medial flaring of the eyebrow (HP:0010747)2.85291855
23Hypsarrhythmia (HP:0002521)2.76521252
24Fetal akinesia sequence (HP:0001989)2.74817869
25Dysdiadochokinesis (HP:0002075)2.64654672
26Absent/shortened dynein arms (HP:0200106)2.62355038
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.62355038
28Congenital primary aphakia (HP:0007707)2.62267738
29Hemiparesis (HP:0001269)2.58632692
30Nephrogenic diabetes insipidus (HP:0009806)2.56676105
31Decreased central vision (HP:0007663)2.56628942
32Bony spicule pigmentary retinopathy (HP:0007737)2.54527367
33Polyphagia (HP:0002591)2.52876722
34Limb dystonia (HP:0002451)2.51824290
35Molar tooth sign on MRI (HP:0002419)2.51498398
36Abnormality of midbrain morphology (HP:0002418)2.51498398
37Congenital stationary night blindness (HP:0007642)2.50344882
38Hepatoblastoma (HP:0002884)2.49582586
39Abnormality of the corticospinal tract (HP:0002492)2.48926175
40Protruding tongue (HP:0010808)2.44971277
41Abnormality of the labia minora (HP:0012880)2.44669452
42Absent speech (HP:0001344)2.44100697
43Lissencephaly (HP:0001339)2.42765079
44Genital tract atresia (HP:0001827)2.41073717
45Genetic anticipation (HP:0003743)2.39899318
46Vaginal atresia (HP:0000148)2.38177076
47Impaired vibration sensation in the lower limbs (HP:0002166)2.36866262
48Pancreatic cysts (HP:0001737)2.36185893
49Abolished electroretinogram (ERG) (HP:0000550)2.34988252
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31871380
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.31871380
52Urinary urgency (HP:0000012)2.29118891
53Vitreoretinal degeneration (HP:0000655)2.28920916
54Status epilepticus (HP:0002133)2.27556402
55Spastic tetraplegia (HP:0002510)2.22956728
56Amblyopia (HP:0000646)2.22945867
57Pachygyria (HP:0001302)2.22514979
58Congenital sensorineural hearing impairment (HP:0008527)2.19095725
59Abnormal eating behavior (HP:0100738)2.14188861
60Retinal dysplasia (HP:0007973)2.14030482
61Poor suck (HP:0002033)2.12411874
62Abnormality of the astrocytes (HP:0100707)2.09721985
63Astrocytoma (HP:0009592)2.09721985
64Chronic hepatic failure (HP:0100626)2.09141605
65Pancreatic fibrosis (HP:0100732)2.08937825
66Intestinal atresia (HP:0011100)2.08692252
67Nephronophthisis (HP:0000090)2.08294096
68Type II lissencephaly (HP:0007260)2.08171758
69Attenuation of retinal blood vessels (HP:0007843)2.06460797
70Abnormality of macular pigmentation (HP:0008002)2.04505883
71Inability to walk (HP:0002540)2.04014388
72Truncal ataxia (HP:0002078)2.02733612
73Urinary bladder sphincter dysfunction (HP:0002839)2.02085961
74Chorioretinal atrophy (HP:0000533)2.02050653
75Epidermoid cyst (HP:0200040)1.99467631
76True hermaphroditism (HP:0010459)1.98734060
77Spastic gait (HP:0002064)1.97099253
78Hypothermia (HP:0002045)1.96270198
79Labial hypoplasia (HP:0000066)1.95050695
80Aplasia/Hypoplasia of the tibia (HP:0005772)1.94441816
81Oligodactyly (hands) (HP:0001180)1.93866549
82Morphological abnormality of the pyramidal tract (HP:0002062)1.90464017
83Abnormal ciliary motility (HP:0012262)1.90141991
84Specific learning disability (HP:0001328)1.89167154
85Constricted visual fields (HP:0001133)1.89156135
86Poor coordination (HP:0002370)1.87418173
87Abnormal respiratory epithelium morphology (HP:0012253)1.86101690
88Abnormal respiratory motile cilium morphology (HP:0005938)1.86101690
89Poor eye contact (HP:0000817)1.85980327
90Esotropia (HP:0000565)1.85782569
91Exotropia (HP:0000577)1.83382789
92Aqueductal stenosis (HP:0002410)1.82041856
93Hypoplasia of the brainstem (HP:0002365)1.81148493
94Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81148493
95Intention tremor (HP:0002080)1.79594096
96Impaired smooth pursuit (HP:0007772)1.78904823
97Horizontal nystagmus (HP:0000666)1.77992758
98Tented upper lip vermilion (HP:0010804)1.77400570
99Optic nerve hypoplasia (HP:0000609)1.72746954
100Impaired vibratory sensation (HP:0002495)1.71163305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.46354932
2MARK15.42106759
3FRK3.90546538
4MAP3K43.36601747
5MAP2K73.01409834
6NTRK33.00426765
7MAPK132.69835725
8WNK32.56727617
9CSNK1G21.94419881
10BCR1.91448648
11NTRK21.84460633
12MAP4K21.78641557
13PINK11.76937549
14EPHA41.73937907
15CSNK1G31.72875766
16MAP2K41.67559939
17NUAK11.59630977
18CSNK1A1L1.58584424
19MINK11.58046537
20TNIK1.57855716
21CSNK1G11.56757007
22PAK31.53763332
23INSRR1.44969487
24BMPR1B1.44472662
25TRIM281.42230094
26DYRK21.37058959
27ADRBK21.32669486
28GRK11.32015142
29PRKCG1.30987826
30ERBB31.14764592
31DAPK21.14559618
32CAMK2A1.09653069
33PNCK1.08255156
34CAMK2B1.07828536
35CDK51.00735372
36ACVR1B0.99851084
37SGK2230.98776299
38SGK4940.98776299
39SGK20.98328585
40EPHA30.97698351
41CAMKK20.95103826
42SIK20.94960956
43PRKCE0.92572978
44UHMK10.82934014
45PHKG20.81519510
46PHKG10.81519510
47PLK20.79448316
48PKN10.78560761
49DYRK1A0.74949216
50GRK50.71827373
51AKT30.71787269
52MAP3K120.67371327
53DAPK10.65673563
54CDK190.65162059
55FGFR20.64213826
56MKNK20.63663083
57OXSR10.62701821
58PAK60.60296552
59PRKCZ0.58459640
60MAP3K60.57990646
61CSNK1D0.57668636
62PRKG10.55088221
63CAMK2D0.52078084
64STK380.51704088
65STK110.50931909
66PRKACA0.50554385
67PIK3CA0.50419349
68SGK10.49536206
69PRKCH0.49443961
70CAMK10.47964835
71CSNK1A10.47830668
72ADRBK10.46911472
73TAOK30.45860800
74PRKAA10.43320416
75CSNK1E0.42551725
76STK390.42478809
77RPS6KA30.40748885
78PRKCA0.40514280
79PRKACB0.40283618
80MAP2K10.40280682
81ZAK0.40234557
82CAMK40.40148765
83PRKCB0.39082667
84MAP2K20.38973272
85TIE10.37115310
86FER0.36875695
87TAOK10.36682984
88CCNB10.36474402
89CAMK2G0.36213929
90CAMKK10.36079951
91SGK30.34621735
92STK38L0.33516849
93CDK180.33232964
94WNK40.32721899
95FYN0.31953723
96MAP2K60.29859074
97PTK2B0.29463933
98CDK140.29279908
99PRKACG0.29190570
100ERBB20.27671804

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.42373588
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.19699558
3GABAergic synapse_Homo sapiens_hsa047272.95780886
4Morphine addiction_Homo sapiens_hsa050322.80196081
5Circadian entrainment_Homo sapiens_hsa047132.70494879
6Glutamatergic synapse_Homo sapiens_hsa047242.60976550
7Taste transduction_Homo sapiens_hsa047422.52259348
8Dopaminergic synapse_Homo sapiens_hsa047282.29172334
9Phototransduction_Homo sapiens_hsa047442.15590854
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15234738
11Insulin secretion_Homo sapiens_hsa049112.05605336
12Cocaine addiction_Homo sapiens_hsa050302.05067837
13Olfactory transduction_Homo sapiens_hsa047402.01517960
14Synaptic vesicle cycle_Homo sapiens_hsa047212.00164225
15Long-term depression_Homo sapiens_hsa047301.92628865
16Amphetamine addiction_Homo sapiens_hsa050311.83701704
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78936868
18Serotonergic synapse_Homo sapiens_hsa047261.78642102
19Long-term potentiation_Homo sapiens_hsa047201.59158762
20Salivary secretion_Homo sapiens_hsa049701.53965438
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.53651236
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49447442
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43161536
24Cholinergic synapse_Homo sapiens_hsa047251.42541890
25Renin secretion_Homo sapiens_hsa049241.36768977
26Calcium signaling pathway_Homo sapiens_hsa040201.30266237
27Butanoate metabolism_Homo sapiens_hsa006501.29891023
28Gastric acid secretion_Homo sapiens_hsa049711.26920260
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26662846
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24878448
31Axon guidance_Homo sapiens_hsa043601.24034563
32Ether lipid metabolism_Homo sapiens_hsa005651.22825309
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18446484
34Nitrogen metabolism_Homo sapiens_hsa009101.17132700
35cAMP signaling pathway_Homo sapiens_hsa040241.11738401
36Collecting duct acid secretion_Homo sapiens_hsa049661.10639036
37Gap junction_Homo sapiens_hsa045401.10134350
38Protein export_Homo sapiens_hsa030601.08373418
39Type II diabetes mellitus_Homo sapiens_hsa049301.06322802
40Cardiac muscle contraction_Homo sapiens_hsa042601.05846139
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00226925
42Oxytocin signaling pathway_Homo sapiens_hsa049210.93240168
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.88607329
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88146233
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83897483
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83353070
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82681094
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79535605
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76140743
50ABC transporters_Homo sapiens_hsa020100.74618855
51Linoleic acid metabolism_Homo sapiens_hsa005910.71436092
52Retinol metabolism_Homo sapiens_hsa008300.69865482
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69728764
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67515914
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67047828
56Pancreatic secretion_Homo sapiens_hsa049720.65094272
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64511902
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63911731
59Dorso-ventral axis formation_Homo sapiens_hsa043200.63649757
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.63118553
61Circadian rhythm_Homo sapiens_hsa047100.62411188
62Ras signaling pathway_Homo sapiens_hsa040140.60852653
63Ovarian steroidogenesis_Homo sapiens_hsa049130.59316951
64Tryptophan metabolism_Homo sapiens_hsa003800.58223665
65beta-Alanine metabolism_Homo sapiens_hsa004100.55931728
66Alzheimers disease_Homo sapiens_hsa050100.55636866
67Oxidative phosphorylation_Homo sapiens_hsa001900.55602308
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54575842
69Chemical carcinogenesis_Homo sapiens_hsa052040.53930853
70Fatty acid biosynthesis_Homo sapiens_hsa000610.53119443
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.51315574
72Glycerolipid metabolism_Homo sapiens_hsa005610.50814627
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49689771
74Thyroid hormone synthesis_Homo sapiens_hsa049180.48854448
75Parkinsons disease_Homo sapiens_hsa050120.48717384
76Regulation of autophagy_Homo sapiens_hsa041400.48615202
77Estrogen signaling pathway_Homo sapiens_hsa049150.47581487
78Alcoholism_Homo sapiens_hsa050340.47199649
79Starch and sucrose metabolism_Homo sapiens_hsa005000.46230575
80Histidine metabolism_Homo sapiens_hsa003400.46081381
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45704022
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.45281651
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45240888
84MAPK signaling pathway_Homo sapiens_hsa040100.42912756
85Oocyte meiosis_Homo sapiens_hsa041140.42500871
86Bile secretion_Homo sapiens_hsa049760.42395961
87ErbB signaling pathway_Homo sapiens_hsa040120.42340437
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41327689
89Hedgehog signaling pathway_Homo sapiens_hsa043400.40559352
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39821520
91Dilated cardiomyopathy_Homo sapiens_hsa054140.39620397
92Sulfur metabolism_Homo sapiens_hsa009200.39036022
93Steroid biosynthesis_Homo sapiens_hsa001000.38159683
94Melanogenesis_Homo sapiens_hsa049160.37301151
95GnRH signaling pathway_Homo sapiens_hsa049120.33702250
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33268712
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33002616
98Rap1 signaling pathway_Homo sapiens_hsa040150.31073700
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31050742
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30785678

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