CNTROB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)7.20910972
2positive regulation of histone deacetylation (GO:0031065)7.15408674
3protoporphyrinogen IX metabolic process (GO:0046501)6.34475487
4N-acetylneuraminate metabolic process (GO:0006054)5.83311102
5cellular extravasation (GO:0045123)5.80087657
6insulin-like growth factor receptor signaling pathway (GO:0048009)5.45406663
7positive regulation of protein deacetylation (GO:0090312)5.42283244
8protein localization to kinetochore (GO:0034501)5.22550928
9DNA unwinding involved in DNA replication (GO:0006268)5.11377508
10mitotic chromosome condensation (GO:0007076)5.06698179
11sister chromatid segregation (GO:0000819)5.06046110
12mitotic sister chromatid segregation (GO:0000070)5.04883806
13positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.84357675
14nuclear pore organization (GO:0006999)4.60098892
15protein localization to chromosome, centromeric region (GO:0071459)4.58093491
16nuclear pore complex assembly (GO:0051292)4.56140423
17mitotic sister chromatid cohesion (GO:0007064)4.42891527
18ribosomal small subunit biogenesis (GO:0042274)4.35880242
19kinetochore organization (GO:0051383)4.34732691
20amino sugar catabolic process (GO:0046348)4.31675491
21regulation of sister chromatid cohesion (GO:0007063)4.23061784
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.22327689
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.15167085
24positive regulation of chemokine biosynthetic process (GO:0045080)4.13945669
25purine deoxyribonucleotide catabolic process (GO:0009155)4.12194429
26regulation of chemokine biosynthetic process (GO:0045073)4.12191819
27negative regulation of erythrocyte differentiation (GO:0045647)4.05706163
28negative regulation of interleukin-2 production (GO:0032703)4.04075935
29meiotic chromosome segregation (GO:0045132)4.02269151
30DNA duplex unwinding (GO:0032508)3.95688131
31regulation of MHC class II biosynthetic process (GO:0045346)3.95359990
32DNA geometric change (GO:0032392)3.94010669
33mitotic nuclear envelope disassembly (GO:0007077)3.93147586
34regulation of histone H3-K9 methylation (GO:0051570)3.92612045
35negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.92479873
36regulation of histone deacetylation (GO:0031063)3.82540433
37DNA replication-dependent nucleosome organization (GO:0034723)3.81615390
38DNA replication-dependent nucleosome assembly (GO:0006335)3.81615390
39DNA strand elongation involved in DNA replication (GO:0006271)3.80015400
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78803384
41mitotic metaphase plate congression (GO:0007080)3.77027357
42negative regulation of histone methylation (GO:0031061)3.72708891
43DNA replication initiation (GO:0006270)3.71059363
44attachment of spindle microtubules to kinetochore (GO:0008608)3.70877674
45nuclear envelope disassembly (GO:0051081)3.70712133
46membrane disassembly (GO:0030397)3.70712133
47metaphase plate congression (GO:0051310)3.66996407
48chromatin assembly (GO:0031497)3.66403388
49dosage compensation (GO:0007549)3.63588646
50DNA strand elongation (GO:0022616)3.62568713
51heterochromatin organization (GO:0070828)3.62426341
52positive regulation of chromosome segregation (GO:0051984)3.60086239
53response to folic acid (GO:0051593)3.59471035
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58942470
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58942470
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.58942470
57chromosome condensation (GO:0030261)3.58908761
58kinetochore assembly (GO:0051382)3.58824015
59chromatin assembly or disassembly (GO:0006333)3.58355519
60mitotic recombination (GO:0006312)3.58245779
61histone H4 deacetylation (GO:0070933)3.58211926
62telomere maintenance via semi-conservative replication (GO:0032201)3.56272293
63protein localization to chromosome (GO:0034502)3.51342160
64negative regulation of mRNA processing (GO:0050686)3.49117679
65regulation of chromosome segregation (GO:0051983)3.47224872
66regulation of centriole replication (GO:0046599)3.46782914
67DNA replication-independent nucleosome assembly (GO:0006336)3.46422834
68DNA replication-independent nucleosome organization (GO:0034724)3.46422834
69disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.45010290
70killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.45010290
71DNA replication checkpoint (GO:0000076)3.44827595
72glial cell migration (GO:0008347)3.44550191
73DNA conformation change (GO:0071103)3.42886920
74pre-miRNA processing (GO:0031054)3.42679590
75chromatin remodeling at centromere (GO:0031055)3.41918529
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41539367
77negative regulation of phagocytosis (GO:0050765)3.40864167
78regulation of protein import into nucleus, translocation (GO:0033158)3.40760593
79pore complex assembly (GO:0046931)3.39462918
80telomere maintenance via recombination (GO:0000722)3.38535183
81chromosome segregation (GO:0007059)3.38345854
82UV protection (GO:0009650)3.35981646
83CENP-A containing nucleosome assembly (GO:0034080)3.34197418
84negative regulation of RNA splicing (GO:0033119)3.33146097
85regulation of DNA damage checkpoint (GO:2000001)3.30682297
86apoptotic process involved in morphogenesis (GO:0060561)3.30583645
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30399599
88establishment of chromosome localization (GO:0051303)3.29088533
89regulation of spindle organization (GO:0090224)3.28930817
90DNA topological change (GO:0006265)3.27530837
91DNA strand renaturation (GO:0000733)3.27467990
92negative regulation of mRNA metabolic process (GO:1903312)3.26619800
93histone H3 deacetylation (GO:0070932)3.23108076
94ATP-dependent chromatin remodeling (GO:0043044)3.22399034
95DNA packaging (GO:0006323)3.22282063
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.21199477
97negative regulation of chromosome segregation (GO:0051985)3.19528076
98DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16136099
99regulation of centrosome cycle (GO:0046605)3.15700906
100negative regulation of histone acetylation (GO:0035067)3.13403827
101folic acid-containing compound biosynthetic process (GO:0009396)3.12416310
102telomere maintenance via telomere lengthening (GO:0010833)3.11614312
103regulation of nuclear cell cycle DNA replication (GO:0033262)3.11051581
104spindle assembly checkpoint (GO:0071173)3.10930985
105histone exchange (GO:0043486)3.10468506
106mRNA stabilization (GO:0048255)3.10226925
107RNA stabilization (GO:0043489)3.10226925
108regulation of mitotic metaphase/anaphase transition (GO:0030071)3.09994318
109base-excision repair, AP site formation (GO:0006285)3.09330901
110translesion synthesis (GO:0019985)3.07639273
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07529259
112microglial cell activation (GO:0001774)3.07367701
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07127774
114negative regulation of sister chromatid segregation (GO:0033046)3.07127774
115negative regulation of mitotic sister chromatid separation (GO:2000816)3.07127774
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07127774
117regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.06549390
118spindle checkpoint (GO:0031577)3.06156560
119positive regulation of DNA-dependent DNA replication (GO:2000105)3.05405540
120regulation of RNA export from nucleus (GO:0046831)3.05175119
121establishment of mitotic spindle localization (GO:0040001)3.04503663
122paraxial mesoderm development (GO:0048339)3.03557210
123regulation of mitotic sister chromatid separation (GO:0010965)3.03324595
124regulation of mitotic sister chromatid segregation (GO:0033047)3.03324595
125regulation of sister chromatid segregation (GO:0033045)3.03324595
126regulation of translational fidelity (GO:0006450)3.02873766
127mitotic spindle assembly checkpoint (GO:0007094)3.02777995
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02753942
129macrophage chemotaxis (GO:0048246)3.02383129
130histone H4-K12 acetylation (GO:0043983)3.02033276
131spindle assembly (GO:0051225)3.00689063
132spliceosomal tri-snRNP complex assembly (GO:0000244)2.99840498
133modulation of growth of symbiont involved in interaction with host (GO:0044144)2.99495745
134regulation of growth of symbiont in host (GO:0044126)2.99495745
135negative regulation of growth of symbiont in host (GO:0044130)2.99495745
136negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.99495745
137modulation by virus of host process (GO:0019054)2.97681652
138nuclear envelope organization (GO:0006998)2.97653928
139regulation of mitotic spindle organization (GO:0060236)2.97489159
140resolution of meiotic recombination intermediates (GO:0000712)2.97466659
141regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97431275
142negative regulation of cell size (GO:0045792)2.95754001
143nucleosome disassembly (GO:0006337)2.94902871
144protein-DNA complex disassembly (GO:0032986)2.94902871
145regulation of erythrocyte differentiation (GO:0045646)2.93704655
146induction of positive chemotaxis (GO:0050930)2.91570815
147regulation of nucleobase-containing compound transport (GO:0032239)2.90837759
148planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86665173
149regulation of protein deacetylation (GO:0090311)2.85799977
150intracellular estrogen receptor signaling pathway (GO:0030520)2.84338952
151DNA damage response, signal transduction resulting in transcription (GO:0042772)2.81416436
152stress granule assembly (GO:0034063)2.81222949
153modulation by symbiont of host cellular process (GO:0044068)2.78647644
154spindle organization (GO:0007051)2.76772443
155glucocorticoid receptor signaling pathway (GO:0042921)2.76625988
156regulation of fatty acid transport (GO:2000191)2.73764743
157mannose metabolic process (GO:0006013)2.72890035
158heme biosynthetic process (GO:0006783)2.72809476
159positive regulation of blood vessel endothelial cell migration (GO:0043536)2.70330599
160histone deacetylation (GO:0016575)2.67438080
161positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.66136184
162peptidyl-arginine omega-N-methylation (GO:0035247)2.65893492
163establishment of mitotic spindle orientation (GO:0000132)2.64703715
164establishment of spindle orientation (GO:0051294)2.63495627
165misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.61725483
166poly(A)+ mRNA export from nucleus (GO:0016973)2.61047768
167neutrophil mediated immunity (GO:0002446)2.60564931
168reactive oxygen species biosynthetic process (GO:1903409)2.60493258
169thalamus development (GO:0021794)2.60410980
170establishment of spindle localization (GO:0051293)2.58746797
171signal complex assembly (GO:0007172)2.58262314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.20658478
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.56103449
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11181521
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.08530157
5MYC_22102868_ChIP-Seq_BL_Human2.94193874
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.77412775
7* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58333285
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.47791271
9LXR_22292898_ChIP-Seq_THP-1_Human2.45573669
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45166861
11AR_21909140_ChIP-Seq_LNCAP_Human2.30779365
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.30335814
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28780666
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.26540567
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24044617
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11076480
17E2F7_22180533_ChIP-Seq_HELA_Human10.8253100
18CIITA_25753668_ChIP-Seq_RAJI_Human1.99640061
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99580640
20MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98187190
21VDR_24763502_ChIP-Seq_THP-1_Human1.95677862
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93353906
23VDR_21846776_ChIP-Seq_THP-1_Human1.88692966
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87963628
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87766973
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86316061
27XRN2_22483619_ChIP-Seq_HELA_Human1.85148922
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.85039848
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84137055
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.82288891
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80848269
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70961595
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67266586
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.66576136
35RACK7_27058665_Chip-Seq_MCF-7_Human1.64416143
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61370600
37SCL_19346495_ChIP-Seq_HPC-7_Human1.58924129
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57044806
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56528341
40KDM5A_27292631_Chip-Seq_BREAST_Human1.55263309
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55211184
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54771413
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.54409748
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53981619
45NCOR1_26117541_ChIP-Seq_K562_Human1.49258603
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.45776741
47P68_20966046_ChIP-Seq_HELA_Human1.45343761
48NANOG_21062744_ChIP-ChIP_HESCs_Human1.44737277
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43643487
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43423912
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41918654
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41708275
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.40123419
54KDM2B_26808549_Chip-Seq_K562_Human1.38556543
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37710922
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.35701998
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35385173
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35104361
59TCF7_22412390_ChIP-Seq_EML_Mouse1.34557565
60SMC4_20622854_ChIP-Seq_HELA_Human1.33598397
61MAF_26560356_Chip-Seq_TH2_Human1.32898334
62* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32689787
63TTF2_22483619_ChIP-Seq_HELA_Human1.32003019
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29764216
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27984974
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27608062
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.26761696
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26352628
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26149806
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25636333
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23820482
72CREB1_26743006_Chip-Seq_LNCaP_Human1.23756244
73FOXP3_21729870_ChIP-Seq_TREG_Human1.23628065
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23497749
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22047258
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21745033
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19954799
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19751552
79* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19601020
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.19555863
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18896519
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18777470
83* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17696607
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15973989
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.14575029
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.14531409
87TP53_22127205_ChIP-Seq_IMR90_Human1.14474045
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14433676
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14295008
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13339995
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13237098
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12906526
93* ATF3_27146783_Chip-Seq_COLON_Human1.12452360
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11675813
95PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10296576
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10222695
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09958712
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09769322
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09475232
100VDR_23849224_ChIP-Seq_CD4+_Human1.08684397
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.08599535
102DCP1A_22483619_ChIP-Seq_HELA_Human1.07506794
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07197810
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06831994
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06346309
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05509704
107GABP_19822575_ChIP-Seq_HepG2_Human1.05325720
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04653801
109KDM2B_26808549_Chip-Seq_DND41_Human1.04606526
110TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04332548
111SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.04301316
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04114642
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03974076
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03727677
115ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03534057
116ETS1_20019798_ChIP-Seq_JURKAT_Human1.03120826
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03099850
118UTX_26944678_Chip-Seq_JUKART_Human1.02627451
119* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02592074
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02233358
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01920784
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00237468
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99905429
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99733925
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99649188
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99649188
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99649188
128ZNF263_19887448_ChIP-Seq_K562_Human0.99168486
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99071504
130BCL6_27268052_Chip-Seq_Bcells_Human0.98350512
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97957595
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96777238
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96181254
134CTCF_26484167_Chip-Seq_Bcells_Mouse0.96051976
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94927413
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94789430
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91634241
138POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90411548
139CHD1_26751641_Chip-Seq_LNCaP_Human0.90378664
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90256960
141CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89677324
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88944882
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87790081
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87719675
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87453767
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86850371
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86746553
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85917407
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.84354855
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83598440
151SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83535716
152MAF_26560356_Chip-Seq_TH1_Human0.79422009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract6.34835499
2MP0010094_abnormal_chromosome_stability4.25936194
3MP0003111_abnormal_nucleus_morphology4.16340442
4MP0005451_abnormal_body_composition3.56799467
5MP0008057_abnormal_DNA_replication3.53186246
6MP0003077_abnormal_cell_cycle3.41801057
7MP0003693_abnormal_embryo_hatching3.35130014
8MP0004957_abnormal_blastocyst_morpholog3.28316704
9MP0003283_abnormal_digestive_organ2.80654148
10MP0008058_abnormal_DNA_repair2.64333195
11MP0000003_abnormal_adipose_tissue2.62166700
12MP0003123_paternal_imprinting2.53825546
13MP0005670_abnormal_white_adipose2.44465587
14MP0005076_abnormal_cell_differentiation2.42276862
15MP0008877_abnormal_DNA_methylation2.40272224
16MP0003121_genomic_imprinting2.37241833
17MP0001730_embryonic_growth_arrest2.33395125
18MP0008007_abnormal_cellular_replicative2.27717782
19MP0000350_abnormal_cell_proliferation2.21555297
20MP0010030_abnormal_orbit_morphology2.08239042
21MP0005375_adipose_tissue_phenotype2.03528014
22MP0010352_gastrointestinal_tract_polyps1.97868426
23MP0005058_abnormal_lysosome_morphology1.97017658
24MP0003890_abnormal_embryonic-extraembry1.91088501
25MP0002653_abnormal_ependyma_morphology1.90522478
26MP0003787_abnormal_imprinting1.88730287
27MP0004197_abnormal_fetal_growth/weight/1.84636935
28MP0002084_abnormal_developmental_patter1.84452720
29MP0002085_abnormal_embryonic_tissue1.84250721
30MP0004185_abnormal_adipocyte_glucose1.82094569
31MP0005380_embryogenesis_phenotype1.78493836
32MP0001672_abnormal_embryogenesis/_devel1.78493836
33MP0008932_abnormal_embryonic_tissue1.76081140
34MP0005666_abnormal_adipose_tissue1.75665319
35MP0009278_abnormal_bone_marrow1.74659800
36MP0000537_abnormal_urethra_morphology1.71112957
37MP0001697_abnormal_embryo_size1.69764210
38MP0010307_abnormal_tumor_latency1.67646388
39MP0003566_abnormal_cell_adhesion1.65247758
40MP0006292_abnormal_olfactory_placode1.56879572
41MP0003705_abnormal_hypodermis_morpholog1.55980297
42MP0003984_embryonic_growth_retardation1.55611894
43MP0003119_abnormal_digestive_system1.55503557
44MP0002088_abnormal_embryonic_growth/wei1.53528502
45MP0001849_ear_inflammation1.52525756
46MP0002396_abnormal_hematopoietic_system1.49412487
47MP0008438_abnormal_cutaneous_collagen1.48531900
48MP0002086_abnormal_extraembryonic_tissu1.47981097
49MP0000569_abnormal_digit_pigmentation1.47646299
50MP0008789_abnormal_olfactory_epithelium1.47057706
51MP0002080_prenatal_lethality1.46332684
52MP0001293_anophthalmia1.44775334
53MP0009672_abnormal_birth_weight1.35702057
54MP0000490_abnormal_crypts_of1.35685127
55MP0004808_abnormal_hematopoietic_stem1.33947840
56MP0005365_abnormal_bile_salt1.32969028
57MP0005394_taste/olfaction_phenotype1.31855509
58MP0005499_abnormal_olfactory_system1.31855509
59MP0002210_abnormal_sex_determination1.31346185
60MP0005171_absent_coat_pigmentation1.29394494
61MP0009053_abnormal_anal_canal1.28659208
62MP0000678_abnormal_parathyroid_gland1.27585697
63MP0004858_abnormal_nervous_system1.27390700
64MP0009703_decreased_birth_body1.27366230
65MP0003172_abnormal_lysosome_physiology1.26108724
66MP0003300_gastrointestinal_ulcer1.24006905
67MP0002970_abnormal_white_adipose1.23771149
68MP0003091_abnormal_cell_migration1.23379025
69MP0000313_abnormal_cell_death1.21862766
70MP0009115_abnormal_fat_cell1.17914825
71MP0003122_maternal_imprinting1.17378949
72MP0005501_abnormal_skin_physiology1.17109798
73MP0003937_abnormal_limbs/digits/tail_de1.16712409
74MP0003252_abnormal_bile_duct1.15417186
75MP0000703_abnormal_thymus_morphology1.15102766
76MP0002019_abnormal_tumor_incidence1.13378426
77MP0004381_abnormal_hair_follicle1.12268279
78MP0001145_abnormal_male_reproductive1.12176606
79MP0000566_synostosis1.11184776
80MP0001929_abnormal_gametogenesis1.10202148
81MP0005409_darkened_coat_color1.09965548
82MP0002092_abnormal_eye_morphology1.08735869
83MP0003453_abnormal_keratinocyte_physiol1.07805033
84MP0003861_abnormal_nervous_system1.07736509
85MP0003115_abnormal_respiratory_system1.07172940
86MP0002932_abnormal_joint_morphology1.05083997
87MP0000428_abnormal_craniofacial_morphol1.04099300
88MP0003935_abnormal_craniofacial_develop1.03969131
89MP0002111_abnormal_tail_morphology1.03232996
90MP0003567_abnormal_fetal_cardiomyocyte1.02701264
91MP0003436_decreased_susceptibility_to1.01637976
92MP0000049_abnormal_middle_ear1.00805305
93MP0004947_skin_inflammation0.99868374
94MP0003786_premature_aging0.99310640
95MP0002697_abnormal_eye_size0.97702347
96MP0005257_abnormal_intraocular_pressure0.96360526
97MP0005621_abnormal_cell_physiology0.96330336
98MP0004043_abnormal_pH_regulation0.96315794
99MP0004233_abnormal_muscle_weight0.95946127
100MP0000653_abnormal_sex_gland0.95329313
101MP0000462_abnormal_digestive_system0.93497732
102MP0000733_abnormal_muscle_development0.93393969
103MP0002116_abnormal_craniofacial_bone0.92586597
104MP0001286_abnormal_eye_development0.92554156
105MP0000432_abnormal_head_morphology0.91980666
106MP0008260_abnormal_autophagy0.90327268
107MP0001545_abnormal_hematopoietic_system0.90285331
108MP0005397_hematopoietic_system_phenotyp0.90285331
109MP0003755_abnormal_palate_morphology0.89807053
110MP0002234_abnormal_pharynx_morphology0.89665573
111MP0009931_abnormal_skin_appearance0.85986923
112MP0003763_abnormal_thymus_physiology0.85955992
113MP0006072_abnormal_retinal_apoptosis0.83818576
114MP0003385_abnormal_body_wall0.83074722
115MP0002877_abnormal_melanocyte_morpholog0.81767063
116MP0003941_abnormal_skin_development0.81226105
117MP0001915_intracranial_hemorrhage0.80706551
118MP0004264_abnormal_extraembryonic_tissu0.79934170
119MP0000015_abnormal_ear_pigmentation0.77925141
120MP0005391_vision/eye_phenotype0.77563546
121MP0002009_preneoplasia0.77435884
122MP0002751_abnormal_autonomic_nervous0.77152323
123MP0002249_abnormal_larynx_morphology0.77115162
124MP0002233_abnormal_nose_morphology0.75927256
125MP0003698_abnormal_male_reproductive0.75477243
126MP0002398_abnormal_bone_marrow0.75383766
127MP0003959_abnormal_lean_body0.75061920
128MP0008961_abnormal_basal_metabolism0.73948657
129MP0002114_abnormal_axial_skeleton0.73747038
130MP0001502_abnormal_circadian_rhythm0.73558324
131MP0002925_abnormal_cardiovascular_devel0.73144812
132MP0010234_abnormal_vibrissa_follicle0.72482193
133MP0002060_abnormal_skin_morphology0.72176326
134MP0000477_abnormal_intestine_morphology0.72147996
135MP0005384_cellular_phenotype0.72106349
136MP0002081_perinatal_lethality0.71815195
137MP0002722_abnormal_immune_system0.71739486
138MP0003942_abnormal_urinary_system0.71653597
139MP0004133_heterotaxia0.70904675
140MP0003943_abnormal_hepatobiliary_system0.70127495
141MP0002075_abnormal_coat/hair_pigmentati0.70089485
142MP0002419_abnormal_innate_immunity0.69665893
143MP0001853_heart_inflammation0.67814119
144MP0000759_abnormal_skeletal_muscle0.67440949
145MP0009840_abnormal_foam_cell0.65983216
146MP0008995_early_reproductive_senescence0.65616354
147MP0002429_abnormal_blood_cell0.63216462
148MP0000858_altered_metastatic_potential0.63070203
149MP0001348_abnormal_lacrimal_gland0.62777094
150MP0003045_fibrosis0.62734683
151MP0003221_abnormal_cardiomyocyte_apopto0.62445174
152MP0003191_abnormal_cellular_cholesterol0.60091666

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.88852458
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84599225
3Ependymoma (HP:0002888)3.61554243
4Broad face (HP:0000283)3.45573879
5Increased nuchal translucency (HP:0010880)3.31944731
6Selective tooth agenesis (HP:0001592)3.24278820
7Ulnar bowing (HP:0003031)3.19134722
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.17635126
9Short 4th metacarpal (HP:0010044)3.17635126
10Volvulus (HP:0002580)3.14726898
11Broad distal phalanx of finger (HP:0009836)2.95580641
12Insomnia (HP:0100785)2.92637547
13Ectopic kidney (HP:0000086)2.89634475
14Abnormal number of incisors (HP:0011064)2.84733224
15Protrusio acetabuli (HP:0003179)2.82596860
16Medulloblastoma (HP:0002885)2.80110502
17Abnormality of chromosome stability (HP:0003220)2.73556268
18Astrocytoma (HP:0009592)2.71451578
19Abnormality of the astrocytes (HP:0100707)2.71451578
20Hyperacusis (HP:0010780)2.69037938
21Patellar aplasia (HP:0006443)2.65066668
22Rib fusion (HP:0000902)2.60440566
23Renal duplication (HP:0000075)2.60336750
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.60052495
25Renovascular hypertension (HP:0100817)2.53615337
26Meckel diverticulum (HP:0002245)2.49355083
27Generalized hyperpigmentation (HP:0007440)2.48332598
28Thrombocytosis (HP:0001894)2.43297820
29Aplasia/Hypoplasia of the patella (HP:0006498)2.43047636
30Proximal placement of thumb (HP:0009623)2.43010650
31High pitched voice (HP:0001620)2.42434594
32Abnormality of the ileum (HP:0001549)2.40919337
33Abnormality of the preputium (HP:0100587)2.39452885
34Neoplasm of the oral cavity (HP:0100649)2.36386228
35Premature rupture of membranes (HP:0001788)2.35295176
36Abnormality of the carotid arteries (HP:0005344)2.34803290
37Deviation of the thumb (HP:0009603)2.34175603
38Heterotopia (HP:0002282)2.31639669
39Abnormality of the fingertips (HP:0001211)2.30953428
40Back pain (HP:0003418)2.30392667
41Flat acetabular roof (HP:0003180)2.28147000
42Neoplasm of striated muscle (HP:0009728)2.27288184
43Broad palm (HP:0001169)2.27161795
44Ureteral stenosis (HP:0000071)2.27115833
45Cafe-au-lait spot (HP:0000957)2.26763137
46Colon cancer (HP:0003003)2.26414727
47Impulsivity (HP:0100710)2.25944494
48Acute lymphatic leukemia (HP:0006721)2.22043519
49Sandal gap (HP:0001852)2.22029533
50Disproportionate tall stature (HP:0001519)2.21177303
51Abnormality of the labia minora (HP:0012880)2.20380435
52Rhabdomyosarcoma (HP:0002859)2.19148299
53Achilles tendon contracture (HP:0001771)2.18153980
54Absent radius (HP:0003974)2.17063456
55Dysmetric saccades (HP:0000641)2.17009578
56Abnormality of the 4th metacarpal (HP:0010012)2.16668148
57Facial hemangioma (HP:0000329)2.16475583
58Glioma (HP:0009733)2.16113274
59Shawl scrotum (HP:0000049)2.15692565
60Prominent nose (HP:0000448)2.15347104
61Biconcave vertebral bodies (HP:0004586)2.15244776
62Myelodysplasia (HP:0002863)2.14606827
63Short phalanx of the thumb (HP:0009660)2.13556026
64Mitral regurgitation (HP:0001653)2.12959984
65Cerebral aneurysm (HP:0004944)2.11418555
66Elfin facies (HP:0004428)2.08907567
67Basal cell carcinoma (HP:0002671)2.08420271
68Aplasia involving forearm bones (HP:0009822)2.07668812
69Absent forearm bone (HP:0003953)2.07668812
70Dislocated radial head (HP:0003083)2.07384000
71Small intestinal stenosis (HP:0012848)2.07165975
72Duodenal stenosis (HP:0100867)2.07165975
73Duplicated collecting system (HP:0000081)2.06703509
74Rectal prolapse (HP:0002035)2.05928231
75Short thumb (HP:0009778)2.05102002
76Reticulocytosis (HP:0001923)2.03609491
77Cervical subluxation (HP:0003308)2.03559094
78Squamous cell carcinoma (HP:0002860)2.03493996
79Renal cell carcinoma (HP:0005584)2.03431171
80Distal lower limb amyotrophy (HP:0008944)2.03230131
81Long eyelashes (HP:0000527)2.02620735
82Absent thumb (HP:0009777)2.01586014
83Abnormal gallbladder physiology (HP:0012438)2.00958244
84Cholecystitis (HP:0001082)2.00958244
85Abnormality of the distal phalanx of the thumb (HP:0009617)1.98366673
86Gastrointestinal carcinoma (HP:0002672)1.98152508
87Malignant gastrointestinal tract tumors (HP:0006749)1.98152508
88Atresia of the external auditory canal (HP:0000413)1.97871255
89Abnormality of the thoracic spine (HP:0100711)1.97424730
90Reticulocytopenia (HP:0001896)1.97380202
91Increased connective tissue (HP:0009025)1.96989758
92Abdominal situs inversus (HP:0003363)1.96721431
93Abnormality of abdominal situs (HP:0011620)1.96721431
94Microvesicular hepatic steatosis (HP:0001414)1.94866254
95Cellulitis (HP:0100658)1.94694212
96Ureteral obstruction (HP:0006000)1.94604321
97Plagiocephaly (HP:0001357)1.94449340
98Truncal obesity (HP:0001956)1.93995250
99Abnormality of the calcaneus (HP:0008364)1.93371545
100Deep palmar crease (HP:0006191)1.93055416
101Fragile skin (HP:0001030)1.92684570
102Vertebral arch anomaly (HP:0008438)1.91403846
103Abnormality of reticulocytes (HP:0004312)1.90442767
104Obsessive-compulsive behavior (HP:0000722)1.90161688
105Self-mutilation (HP:0000742)1.89653852
106Abnormality of the radial head (HP:0003995)1.89132589
107Supernumerary spleens (HP:0009799)1.88393655
108Abnormality of the 1st metacarpal (HP:0010009)1.87976341
109Bladder diverticulum (HP:0000015)1.87535071
110Flattened epiphyses (HP:0003071)1.87206315
111Trigonocephaly (HP:0000243)1.86217301
112Missing ribs (HP:0000921)1.86050194
113J-shaped sella turcica (HP:0002680)1.85450461
114Supernumerary ribs (HP:0005815)1.84770953
115Breast hypoplasia (HP:0003187)1.84561910
116Flared metaphyses (HP:0003015)1.83971732
117Abnormality of the phalanges of the hallux (HP:0010057)1.83718834
118Nephroblastoma (Wilms tumor) (HP:0002667)1.83629856
119Birth length less than 3rd percentile (HP:0003561)1.83329962
120Tracheoesophageal fistula (HP:0002575)1.83259035
121Thoracic kyphosis (HP:0002942)1.83179552
122Obstructive sleep apnea (HP:0002870)1.83161565
123Abnormality of the duodenum (HP:0002246)1.82991971
124Supernumerary bones of the axial skeleton (HP:0009144)1.82978718
125Mitral valve prolapse (HP:0001634)1.81907561
126Neoplasm of the pancreas (HP:0002894)1.81406969
127Skull defect (HP:0001362)1.80351441
128Overriding aorta (HP:0002623)1.80207751
129Abnormality of the Achilles tendon (HP:0005109)1.79894579
130Pseudobulbar signs (HP:0002200)1.79665314
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.79473548
132Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78420752
133Long palpebral fissure (HP:0000637)1.77274485
134Sloping forehead (HP:0000340)1.76973581
135Pointed chin (HP:0000307)1.76972857
136Abnormality of the lower motor neuron (HP:0002366)1.76797892
137Patellar dislocation (HP:0002999)1.76757953
13811 pairs of ribs (HP:0000878)1.76537550
139Overlapping toe (HP:0001845)1.75951069
140Turricephaly (HP:0000262)1.75908526
141Vertebral compression fractures (HP:0002953)1.75037587
142Megalocornea (HP:0000485)1.73711918
143Shallow orbits (HP:0000586)1.72870916
144Biliary tract neoplasm (HP:0100574)1.72335104
145Abnormality of the renal collecting system (HP:0004742)1.72233473
146Hemivertebrae (HP:0002937)1.70933156
147High anterior hairline (HP:0009890)1.70031091
148Flat cornea (HP:0007720)1.69840949
149Skin tags (HP:0010609)1.68900536
150Abnormality of the diencephalon (HP:0010662)1.68045742
151Abnormality of chromosome segregation (HP:0002916)1.66597091
152Short nail (HP:0001799)1.66045968
153Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.65916495
154Hypopigmentation of the fundus (HP:0007894)1.65748497
155Spinal rigidity (HP:0003306)1.65259569
156Distal upper limb amyotrophy (HP:0007149)1.64249296
157Upper limb amyotrophy (HP:0009129)1.64249296
158Thin skin (HP:0000963)1.63594800
159Obstructive lung disease (HP:0006536)1.61947981
160Chronic obstructive pulmonary disease (HP:0006510)1.61947981
161Spina bifida occulta (HP:0003298)1.61926650
162Blue sclerae (HP:0000592)1.61752052
163Neoplasm of the adrenal cortex (HP:0100641)1.61166985
164Neonatal hypoglycemia (HP:0001998)1.60615730
165Cutaneous photosensitivity (HP:0000992)1.60392178
166Deformed sella turcica (HP:0002681)1.60047073
167Hepatosplenomegaly (HP:0001433)1.58833409
168Dysostosis multiplex (HP:0000943)1.58465887
169Breech presentation (HP:0001623)1.57276934
170Slender long bone (HP:0003100)1.53897802
171Centrally nucleated skeletal muscle fibers (HP:0003687)1.53865774
172Viral hepatitis (HP:0006562)1.53845997
173Abnormality of the prostate (HP:0008775)1.51949040
174Aortic regurgitation (HP:0001659)1.51055402
175Polygenic inheritance (HP:0010982)1.50127649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.72413403
2SMG14.70202180
3CDC74.64916309
4MAP3K103.45876296
5* NEK23.27940016
6EEF2K3.11000650
7ERN13.10352948
8TTK2.99611631
9PRPF4B2.98462746
10IRAK32.96017873
11BRD42.53519970
12ACVR1B2.50849072
13BUB12.34023601
14PASK2.20288088
15ICK2.17202498
16WEE12.08155816
17VRK22.03268084
18ATR1.88813994
19CAMKK21.82396987
20RPS6KB21.76893233
21PLK11.76682477
22NEK11.72638689
23CDK71.72132622
24LATS21.72102070
25TAF11.69448964
26STK101.67841283
27CDK41.65141574
28SRPK11.60435067
29MAP2K31.60072824
30TRIB31.55527940
31PKN21.53962967
32SIK21.51847930
33CCNB11.51700592
34CHEK11.50972427
35CHEK21.44783591
36PLK41.40123643
37AURKB1.38693076
38PRKD31.37212616
39DYRK31.35794137
40TYRO31.34786209
41MAP3K71.33949749
42NME21.31621362
43TLK11.29184185
44STK41.22648415
45MAP3K81.21520260
46CDK61.19953193
47CAMKK11.19671593
48ATM1.15691942
49MKNK21.14044309
50MARK21.13421232
51MKNK11.13260577
52TTN1.11335609
53PAK41.10640633
54ALK1.07456400
55CDK21.07449075
56MELK1.06512688
57BRSK11.06183069
58MTOR1.04900464
59CDK91.03063756
60AURKA0.93585979
61PDGFRA0.92235181
62TAOK20.92086181
63PTK60.90456126
64LATS10.89227526
65CDK10.87963669
66CHUK0.83594326
67PNCK0.83495114
68MAP2K20.82425508
69TSSK60.82068572
70DYRK1B0.79607614
71PLK30.79097806
72YES10.76854720
73TGFBR10.75191777
74TESK10.72898281
75KSR20.72094245
76STK30.67972694
77DDR20.65865559
78HIPK20.65348548
79UHMK10.64032107
80SIK10.63027701
81RPS6KA40.61530181
82MAP3K130.60274742
83MOS0.60234079
84TESK20.57220534
85MAPKAPK50.56896714
86PRKDC0.56300307
87GRK60.55561334
88CDC42BPA0.54680082
89CDK80.53763000
90MAPK110.53172164
91AKT20.52648566
92PIM10.52524494
93MAPK140.52259024
94PDPK10.52177913
95RIPK10.49835271
96FGFR40.48835892
97GSK3B0.48790271
98MAP3K110.48595195
99AKT10.47870041
100RPS6KC10.46637314
101RPS6KL10.46637314
102BRAF0.46607968
103BRSK20.46049856
104FGFR10.45845049
105MAP4K10.45784728
106PRKCI0.45696153
107CLK10.45231438
108MST1R0.44699212
109CSNK1E0.43746231
110CSNK1D0.43494148
111CAMK1G0.42972135
112ERBB20.42935913
113NTRK10.41033734
114KSR10.39160089
115PRKD20.39056512
116VRK10.38720264
117MAPK40.38483807
118BMX0.35347109
119PDGFRB0.35259072
120FLT30.35079887
121MAPK90.34965978
122MAP3K30.34712448
123CSNK2A20.34328602
124MAP3K60.33523797
125MAPK10.33447893
126PAK20.33415596
127EPHA20.31956243
128MARK30.31342211
129RET0.29794907
130CAMK40.29149193
131RPS6KA60.28677047
132MAP3K10.28615365
133PRKAA20.28590594
134IRAK20.28589447
135MAPKAPK20.28574127
136MET0.28407315
137MAPK100.28047869
138MATK0.27348871
139CAMK1D0.26728792
140LRRK20.26417458
141MAPK80.26410644
142NEK90.26321695
143CAMK10.25855857
144ZAP700.25828820
145PTK20.24481728

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48325928
2Mismatch repair_Homo sapiens_hsa034304.01142771
3Base excision repair_Homo sapiens_hsa034103.40045520
4Cell cycle_Homo sapiens_hsa041103.24157284
5Homologous recombination_Homo sapiens_hsa034403.04157728
6Spliceosome_Homo sapiens_hsa030403.03479345
7Fanconi anemia pathway_Homo sapiens_hsa034602.80239047
8RNA transport_Homo sapiens_hsa030132.77388870
9mRNA surveillance pathway_Homo sapiens_hsa030152.56857252
10One carbon pool by folate_Homo sapiens_hsa006702.38374016
11Nucleotide excision repair_Homo sapiens_hsa034202.37978339
12Non-homologous end-joining_Homo sapiens_hsa034502.23009164
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.19451148
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17943944
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.11445804
16Other glycan degradation_Homo sapiens_hsa005112.04592403
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89465108
18RNA degradation_Homo sapiens_hsa030181.73029687
19p53 signaling pathway_Homo sapiens_hsa041151.72791663
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63959408
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62375355
22Lysine degradation_Homo sapiens_hsa003101.60285101
23Notch signaling pathway_Homo sapiens_hsa043301.54220620
24Systemic lupus erythematosus_Homo sapiens_hsa053221.53187628
25MicroRNAs in cancer_Homo sapiens_hsa052061.49818392
26Basal cell carcinoma_Homo sapiens_hsa052171.47163083
27Oocyte meiosis_Homo sapiens_hsa041141.46089847
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45304573
29Pyrimidine metabolism_Homo sapiens_hsa002401.30055133
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29684169
31Basal transcription factors_Homo sapiens_hsa030221.28066116
32Viral carcinogenesis_Homo sapiens_hsa052031.26532282
33Renin-angiotensin system_Homo sapiens_hsa046141.26454699
34HTLV-I infection_Homo sapiens_hsa051661.25336494
35Hedgehog signaling pathway_Homo sapiens_hsa043401.21626040
36Chronic myeloid leukemia_Homo sapiens_hsa052201.21159957
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17029457
38Pentose phosphate pathway_Homo sapiens_hsa000301.11096249
39Hippo signaling pathway_Homo sapiens_hsa043901.08476343
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07381142
41Bladder cancer_Homo sapiens_hsa052191.07340270
42Colorectal cancer_Homo sapiens_hsa052101.05040218
43RNA polymerase_Homo sapiens_hsa030201.04474557
44Alcoholism_Homo sapiens_hsa050341.03158975
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.01853889
46mTOR signaling pathway_Homo sapiens_hsa041501.00840654
47Fructose and mannose metabolism_Homo sapiens_hsa000510.99269029
48Non-small cell lung cancer_Homo sapiens_hsa052230.98762934
49Small cell lung cancer_Homo sapiens_hsa052220.98738555
50Selenocompound metabolism_Homo sapiens_hsa004500.92695459
51Adherens junction_Homo sapiens_hsa045200.91259244
52Biosynthesis of amino acids_Homo sapiens_hsa012300.90770795
53Epstein-Barr virus infection_Homo sapiens_hsa051690.90609428
54Amoebiasis_Homo sapiens_hsa051460.88112020
55Lysosome_Homo sapiens_hsa041420.87364801
56Prion diseases_Homo sapiens_hsa050200.86868279
57Thyroid cancer_Homo sapiens_hsa052160.86319259
58Wnt signaling pathway_Homo sapiens_hsa043100.85943687
59Herpes simplex infection_Homo sapiens_hsa051680.82243891
60TGF-beta signaling pathway_Homo sapiens_hsa043500.80614439
61Osteoclast differentiation_Homo sapiens_hsa043800.79137725
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73791887
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.72344728
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.72273871
65Endometrial cancer_Homo sapiens_hsa052130.71671449
66Choline metabolism in cancer_Homo sapiens_hsa052310.71079847
67Acute myeloid leukemia_Homo sapiens_hsa052210.70783379
68Galactose metabolism_Homo sapiens_hsa000520.70752372
69ECM-receptor interaction_Homo sapiens_hsa045120.69521547
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.69073199
71Prostate cancer_Homo sapiens_hsa052150.68959414
72Primary immunodeficiency_Homo sapiens_hsa053400.68194273
73Pathways in cancer_Homo sapiens_hsa052000.66259055
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.64916998
75Antigen processing and presentation_Homo sapiens_hsa046120.64554804
76Hepatitis B_Homo sapiens_hsa051610.64010993
77Phototransduction_Homo sapiens_hsa047440.63638635
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61474283
79Ribosome_Homo sapiens_hsa030100.61104852
80Pancreatic cancer_Homo sapiens_hsa052120.59463721
81Proteoglycans in cancer_Homo sapiens_hsa052050.59445995
82Influenza A_Homo sapiens_hsa051640.59332762
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59278674
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.58688941
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58682580
86B cell receptor signaling pathway_Homo sapiens_hsa046620.56081283
87GnRH signaling pathway_Homo sapiens_hsa049120.55876776
88Purine metabolism_Homo sapiens_hsa002300.55387034
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55347647
90Glioma_Homo sapiens_hsa052140.55233967
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.54164910
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53766461
93Platelet activation_Homo sapiens_hsa046110.53151823
94Inositol phosphate metabolism_Homo sapiens_hsa005620.52903715
95Sulfur relay system_Homo sapiens_hsa041220.52874143
96FoxO signaling pathway_Homo sapiens_hsa040680.52134829
97AMPK signaling pathway_Homo sapiens_hsa041520.50060405
98Hepatitis C_Homo sapiens_hsa051600.49651445
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49387039
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48646796
101Dorso-ventral axis formation_Homo sapiens_hsa043200.46493669
102TNF signaling pathway_Homo sapiens_hsa046680.46047731
103Apoptosis_Homo sapiens_hsa042100.45179733
104T cell receptor signaling pathway_Homo sapiens_hsa046600.45118029
105ErbB signaling pathway_Homo sapiens_hsa040120.44865382
106Toxoplasmosis_Homo sapiens_hsa051450.44789147
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44604066
108Shigellosis_Homo sapiens_hsa051310.44415632
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42724845
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42681933
111Tight junction_Homo sapiens_hsa045300.41449893
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41449131
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40726856
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40660402
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.39601383
116Melanoma_Homo sapiens_hsa052180.38491054
117Estrogen signaling pathway_Homo sapiens_hsa049150.38201668
118Glucagon signaling pathway_Homo sapiens_hsa049220.37817017
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.35706302
120Viral myocarditis_Homo sapiens_hsa054160.34368049
121Renal cell carcinoma_Homo sapiens_hsa052110.33441878
122VEGF signaling pathway_Homo sapiens_hsa043700.33115865
123Insulin signaling pathway_Homo sapiens_hsa049100.31439320
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30851775
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29069524
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28056232
127Melanogenesis_Homo sapiens_hsa049160.27900006
128Prolactin signaling pathway_Homo sapiens_hsa049170.27764377
129Focal adhesion_Homo sapiens_hsa045100.27674368
130N-Glycan biosynthesis_Homo sapiens_hsa005100.25614714
131Type II diabetes mellitus_Homo sapiens_hsa049300.25219987
132Axon guidance_Homo sapiens_hsa043600.25166356
133Insulin resistance_Homo sapiens_hsa049310.24737637
134HIF-1 signaling pathway_Homo sapiens_hsa040660.24228131
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23604501

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