

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chromatin remodeling at centromere (GO:0031055) | 4.65388194 |
| 2 | CENP-A containing nucleosome assembly (GO:0034080) | 4.52877172 |
| 3 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.44223765 |
| 4 | DNA replication checkpoint (GO:0000076) | 4.31767386 |
| 5 | proteasome assembly (GO:0043248) | 4.21630039 |
| 6 | replication fork processing (GO:0031297) | 3.92266088 |
| 7 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.85400494 |
| 8 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.85400494 |
| 9 | chaperone-mediated protein transport (GO:0072321) | 3.84062586 |
| 10 | histone exchange (GO:0043486) | 3.79915413 |
| 11 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.78594833 |
| 12 | ATP synthesis coupled proton transport (GO:0015986) | 3.78594833 |
| 13 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.72542624 |
| 14 | kinetochore organization (GO:0051383) | 3.69836163 |
| 15 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.68570251 |
| 16 | kinetochore assembly (GO:0051382) | 3.68462683 |
| 17 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.64126206 |
| 18 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.62791199 |
| 19 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.62590796 |
| 20 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.62366200 |
| 21 | DNA double-strand break processing (GO:0000729) | 3.60038482 |
| 22 | * protein complex biogenesis (GO:0070271) | 3.51589702 |
| 23 | * mitochondrial respiratory chain complex assembly (GO:0033108) | 3.49777915 |
| 24 | regulation of mitochondrial translation (GO:0070129) | 3.49194761 |
| 25 | DNA strand elongation (GO:0022616) | 3.49102534 |
| 26 | establishment of integrated proviral latency (GO:0075713) | 3.46528520 |
| 27 | DNA replication-independent nucleosome organization (GO:0034724) | 3.45845946 |
| 28 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.45845946 |
| 29 | pseudouridine synthesis (GO:0001522) | 3.45594670 |
| 30 | telomere maintenance via recombination (GO:0000722) | 3.35995326 |
| 31 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.33942723 |
| 32 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.31775673 |
| 33 | * mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.29284429 |
| 34 | * NADH dehydrogenase complex assembly (GO:0010257) | 3.29284429 |
| 35 | * mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.29284429 |
| 36 | respiratory electron transport chain (GO:0022904) | 3.26666990 |
| 37 | mitotic recombination (GO:0006312) | 3.24951461 |
| 38 | peptidyl-histidine modification (GO:0018202) | 3.23280810 |
| 39 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.20857623 |
| 40 | electron transport chain (GO:0022900) | 3.20835327 |
| 41 | resolution of meiotic recombination intermediates (GO:0000712) | 3.19452067 |
| 42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.15662343 |
| 43 | protein K6-linked ubiquitination (GO:0085020) | 3.14297277 |
| 44 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.12293275 |
| 45 | termination of RNA polymerase III transcription (GO:0006386) | 3.12293275 |
| 46 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.11901774 |
| 47 | synapsis (GO:0007129) | 3.10148104 |
| 48 | recombinational repair (GO:0000725) | 3.09989246 |
| 49 | rRNA modification (GO:0000154) | 3.09742783 |
| 50 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.07933672 |
| 51 | spindle checkpoint (GO:0031577) | 3.07862478 |
| 52 | double-strand break repair via homologous recombination (GO:0000724) | 3.07122650 |
| 53 | mitotic sister chromatid segregation (GO:0000070) | 3.06580985 |
| 54 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.06444900 |
| 55 | spliceosomal snRNP assembly (GO:0000387) | 3.04993196 |
| 56 | protein localization to kinetochore (GO:0034501) | 3.04429704 |
| 57 | mitotic metaphase plate congression (GO:0007080) | 3.03856045 |
| 58 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.03404976 |
| 59 | negative regulation of sister chromatid segregation (GO:0033046) | 3.03404976 |
| 60 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.03404976 |
| 61 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.03404976 |
| 62 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.03404976 |
| 63 | negative regulation of chromosome segregation (GO:0051985) | 3.02471713 |
| 64 | mitotic spindle checkpoint (GO:0071174) | 3.01906024 |
| 65 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.01269608 |
| 66 | histone mRNA metabolic process (GO:0008334) | 3.01087330 |
| 67 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.97911649 |
| 68 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.97911649 |
| 69 | DNA ligation (GO:0006266) | 2.95746792 |
| 70 | protein neddylation (GO:0045116) | 2.95577398 |
| 71 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.94918976 |
| 72 | negative regulation of ligase activity (GO:0051352) | 2.94918976 |
| 73 | centriole replication (GO:0007099) | 2.94352599 |
| 74 | * respiratory chain complex IV assembly (GO:0008535) | 2.93315286 |
| 75 | ribosomal small subunit assembly (GO:0000028) | 2.89054182 |
| 76 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.88951707 |
| 77 | sister chromatid segregation (GO:0000819) | 2.88464228 |
| 78 | purine nucleobase biosynthetic process (GO:0009113) | 2.88416864 |
| 79 | metaphase plate congression (GO:0051310) | 2.87571354 |
| 80 | mitotic spindle assembly checkpoint (GO:0007094) | 2.83595916 |
| 81 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.81664095 |
| 82 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.81664095 |
| 83 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.79603285 |
| 84 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.79603285 |
| 85 | spindle assembly checkpoint (GO:0071173) | 2.79279540 |
| 86 | telomere maintenance via telomere lengthening (GO:0010833) | 2.78975705 |
| 87 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.78499712 |
| 88 | nucleobase biosynthetic process (GO:0046112) | 2.78237452 |
| 89 | postreplication repair (GO:0006301) | 2.77400215 |
| 90 | maturation of 5.8S rRNA (GO:0000460) | 2.76329322 |
| 91 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.75400620 |
| 92 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.75400620 |
| 93 | * cytochrome complex assembly (GO:0017004) | 2.73457640 |
| 94 | regulation of sister chromatid segregation (GO:0033045) | 2.72501240 |
| 95 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.72501240 |
| 96 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.72501240 |
| 97 | mitochondrial RNA metabolic process (GO:0000959) | 2.70246836 |
| 98 | meiotic chromosome segregation (GO:0045132) | 2.69943180 |
| 99 | tRNA processing (GO:0008033) | 2.68709469 |
| 100 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.68529512 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.93804563 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.53472128 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.84976640 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.83707654 |
| 5 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.83415430 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.47217548 |
| 7 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.25693030 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.95512762 |
| 9 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.74361475 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.69016308 |
| 11 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.67711460 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.65237212 |
| 13 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.64785801 |
| 14 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.61304825 |
| 15 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.59086943 |
| 16 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.59067697 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.59044655 |
| 18 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.42848332 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.41051192 |
| 20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.19421073 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.08164492 |
| 22 | EWS_26573619_Chip-Seq_HEK293_Human | 2.03593418 |
| 23 | VDR_22108803_ChIP-Seq_LS180_Human | 2.03131866 |
| 24 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.96086712 |
| 25 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.91322540 |
| 26 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.88664802 |
| 27 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.87841740 |
| 28 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.87241959 |
| 29 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.85885629 |
| 30 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84452029 |
| 31 | FUS_26573619_Chip-Seq_HEK293_Human | 1.83195283 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.82616860 |
| 33 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.74414039 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.72983134 |
| 35 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.71721034 |
| 36 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.69586607 |
| 37 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.67953119 |
| 38 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.66242194 |
| 39 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.64748228 |
| 40 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.64195251 |
| 41 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.63460942 |
| 42 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.56369028 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.54673210 |
| 44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.45554119 |
| 45 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.45531120 |
| 46 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.45379596 |
| 47 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.44540657 |
| 48 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.43016198 |
| 49 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.42819764 |
| 50 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.42176108 |
| 51 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.38670691 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.34305200 |
| 53 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.32788380 |
| 54 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.32224315 |
| 55 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.25713305 |
| 56 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.24369642 |
| 57 | P300_19829295_ChIP-Seq_ESCs_Human | 1.23270376 |
| 58 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.21797128 |
| 59 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.18381619 |
| 60 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.17985022 |
| 61 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.16348676 |
| 62 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.15916856 |
| 63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.12944206 |
| 64 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.12486974 |
| 65 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.10328361 |
| 66 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.09659358 |
| 67 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.08140745 |
| 68 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.07496357 |
| 69 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.07384061 |
| 70 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.06783377 |
| 71 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.06430957 |
| 72 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.06290287 |
| 73 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.05994262 |
| 74 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.05966489 |
| 75 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.05217516 |
| 76 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.05053513 |
| 77 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.04455070 |
| 78 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.03828403 |
| 79 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.03397929 |
| 80 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.03285226 |
| 81 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.01680741 |
| 82 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.00828948 |
| 83 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99766493 |
| 84 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.94661570 |
| 85 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.93644695 |
| 86 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.89160993 |
| 87 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.89160993 |
| 88 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.88719540 |
| 89 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.86675665 |
| 90 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.85426998 |
| 91 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.84574188 |
| 92 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.83660558 |
| 93 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.83323005 |
| 94 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.82808041 |
| 95 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.82542045 |
| 96 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.81800299 |
| 97 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.80521255 |
| 98 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.79455210 |
| 99 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.78380687 |
| 100 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.75525251 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 3.81012300 |
| 2 | MP0008058_abnormal_DNA_repair | 3.74085403 |
| 3 | MP0008057_abnormal_DNA_replication | 3.60172285 |
| 4 | MP0008877_abnormal_DNA_methylation | 3.21744717 |
| 5 | MP0003693_abnormal_embryo_hatching | 3.07681320 |
| 6 | MP0006292_abnormal_olfactory_placode | 3.04916701 |
| 7 | MP0003111_abnormal_nucleus_morphology | 2.82625590 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.61718120 |
| 9 | MP0003718_maternal_effect | 2.53511879 |
| 10 | MP0003077_abnormal_cell_cycle | 2.52844201 |
| 11 | MP0002102_abnormal_ear_morphology | 2.32780017 |
| 12 | MP0003136_yellow_coat_color | 2.20686777 |
| 13 | MP0002938_white_spotting | 2.15408655 |
| 14 | MP0001529_abnormal_vocalization | 2.04080466 |
| 15 | MP0008932_abnormal_embryonic_tissue | 2.03558326 |
| 16 | MP0009697_abnormal_copulation | 1.98285170 |
| 17 | MP0000372_irregular_coat_pigmentation | 1.95548476 |
| 18 | MP0003786_premature_aging | 1.87543305 |
| 19 | MP0008007_abnormal_cellular_replicative | 1.82432364 |
| 20 | MP0002163_abnormal_gland_morphology | 1.80146521 |
| 21 | MP0001293_anophthalmia | 1.78654781 |
| 22 | MP0000569_abnormal_digit_pigmentation | 1.73920113 |
| 23 | MP0006072_abnormal_retinal_apoptosis | 1.66646289 |
| 24 | MP0008995_early_reproductive_senescence | 1.62046757 |
| 25 | MP0003195_calcinosis | 1.54432406 |
| 26 | MP0006035_abnormal_mitochondrial_morpho | 1.53897816 |
| 27 | MP0003890_abnormal_embryonic-extraembry | 1.51931343 |
| 28 | MP0003646_muscle_fatigue | 1.49375970 |
| 29 | MP0010030_abnormal_orbit_morphology | 1.48048991 |
| 30 | MP0003787_abnormal_imprinting | 1.46127455 |
| 31 | MP0003567_abnormal_fetal_cardiomyocyte | 1.46078020 |
| 32 | MP0003121_genomic_imprinting | 1.40892276 |
| 33 | MP0003937_abnormal_limbs/digits/tail_de | 1.37649888 |
| 34 | MP0006036_abnormal_mitochondrial_physio | 1.36152017 |
| 35 | MP0004147_increased_porphyrin_level | 1.34410138 |
| 36 | MP0002210_abnormal_sex_determination | 1.33911436 |
| 37 | MP0002638_abnormal_pupillary_reflex | 1.28727867 |
| 38 | MP0003186_abnormal_redox_activity | 1.28715752 |
| 39 | MP0001929_abnormal_gametogenesis | 1.27588286 |
| 40 | MP0000631_abnormal_neuroendocrine_gland | 1.25715899 |
| 41 | MP0005253_abnormal_eye_physiology | 1.23239211 |
| 42 | MP0001346_abnormal_lacrimal_gland | 1.21705625 |
| 43 | MP0008789_abnormal_olfactory_epithelium | 1.20897233 |
| 44 | MP0002837_dystrophic_cardiac_calcinosis | 1.18953904 |
| 45 | MP0005551_abnormal_eye_electrophysiolog | 1.17526061 |
| 46 | MP0003806_abnormal_nucleotide_metabolis | 1.15952002 |
| 47 | MP0001984_abnormal_olfaction | 1.15611497 |
| 48 | MP0009379_abnormal_foot_pigmentation | 1.15120359 |
| 49 | MP0002653_abnormal_ependyma_morphology | 1.11527547 |
| 50 | MP0000653_abnormal_sex_gland | 1.10937841 |
| 51 | MP0000427_abnormal_hair_cycle | 1.10621415 |
| 52 | MP0001145_abnormal_male_reproductive | 1.08050513 |
| 53 | MP0002736_abnormal_nociception_after | 1.06739023 |
| 54 | MP0002751_abnormal_autonomic_nervous | 1.05363306 |
| 55 | MP0004142_abnormal_muscle_tone | 1.03513955 |
| 56 | MP0002234_abnormal_pharynx_morphology | 1.03357831 |
| 57 | MP0005174_abnormal_tail_pigmentation | 1.03027683 |
| 58 | MP0001286_abnormal_eye_development | 1.02098638 |
| 59 | MP0001697_abnormal_embryo_size | 1.01358566 |
| 60 | MP0002160_abnormal_reproductive_system | 1.00842921 |
| 61 | MP0005379_endocrine/exocrine_gland_phen | 1.00198067 |
| 62 | MP0003941_abnormal_skin_development | 0.99921131 |
| 63 | MP0000647_abnormal_sebaceous_gland | 0.98741243 |
| 64 | MP0005408_hypopigmentation | 0.98619182 |
| 65 | MP0002095_abnormal_skin_pigmentation | 0.98188128 |
| 66 | MP0003698_abnormal_male_reproductive | 0.97813618 |
| 67 | MP0001764_abnormal_homeostasis | 0.96965454 |
| 68 | MP0005395_other_phenotype | 0.93751296 |
| 69 | MP0005646_abnormal_pituitary_gland | 0.93270829 |
| 70 | MP0009046_muscle_twitch | 0.92161031 |
| 71 | MP0001119_abnormal_female_reproductive | 0.90904806 |
| 72 | MP0002233_abnormal_nose_morphology | 0.88846634 |
| 73 | MP0005075_abnormal_melanosome_morpholog | 0.88554238 |
| 74 | MP0004133_heterotaxia | 0.87737004 |
| 75 | MP0003119_abnormal_digestive_system | 0.86926705 |
| 76 | MP0000350_abnormal_cell_proliferation | 0.85538473 |
| 77 | MP0001672_abnormal_embryogenesis/_devel | 0.85470293 |
| 78 | MP0005380_embryogenesis_phenotype | 0.85470293 |
| 79 | MP0000049_abnormal_middle_ear | 0.84472732 |
| 80 | MP0004215_abnormal_myocardial_fiber | 0.83669498 |
| 81 | MP0005394_taste/olfaction_phenotype | 0.83514809 |
| 82 | MP0005499_abnormal_olfactory_system | 0.83514809 |
| 83 | MP0005389_reproductive_system_phenotype | 0.83502074 |
| 84 | MP0000358_abnormal_cell_content/ | 0.83124474 |
| 85 | MP0002084_abnormal_developmental_patter | 0.82359416 |
| 86 | MP0001968_abnormal_touch/_nociception | 0.81382638 |
| 87 | MP0002697_abnormal_eye_size | 0.80554272 |
| 88 | MP0005391_vision/eye_phenotype | 0.80347395 |
| 89 | MP0002085_abnormal_embryonic_tissue | 0.80017698 |
| 90 | MP0001485_abnormal_pinna_reflex | 0.79928393 |
| 91 | MP0005084_abnormal_gallbladder_morpholo | 0.78714478 |
| 92 | MP0002088_abnormal_embryonic_growth/wei | 0.72714971 |
| 93 | MP0005187_abnormal_penis_morphology | 0.72466635 |
| 94 | MP0008872_abnormal_physiological_respon | 0.72453203 |
| 95 | MP0005645_abnormal_hypothalamus_physiol | 0.72018207 |
| 96 | MP0003984_embryonic_growth_retardation | 0.71626077 |
| 97 | MP0010307_abnormal_tumor_latency | 0.70489236 |
| 98 | MP0006276_abnormal_autonomic_nervous | 0.70478652 |
| 99 | MP0000313_abnormal_cell_death | 0.69213107 |
| 100 | MP0001324_abnormal_eye_pigmentation | 0.68601591 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.85588076 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.49614446 |
| 3 | Acute encephalopathy (HP:0006846) | 3.45228233 |
| 4 | Mitochondrial inheritance (HP:0001427) | 3.37668655 |
| 5 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.35204384 |
| 6 | Increased CSF lactate (HP:0002490) | 3.35013787 |
| 7 | Pancreatic cysts (HP:0001737) | 3.31758820 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.26456396 |
| 9 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.26387582 |
| 10 | Chromsome breakage (HP:0040012) | 3.17549040 |
| 11 | Colon cancer (HP:0003003) | 3.14032804 |
| 12 | Meckel diverticulum (HP:0002245) | 3.11654572 |
| 13 | Abnormality of chromosome stability (HP:0003220) | 3.11566049 |
| 14 | Pancreatic fibrosis (HP:0100732) | 3.08424638 |
| 15 | Hepatocellular necrosis (HP:0001404) | 3.03906218 |
| 16 | Abnormality of the ileum (HP:0001549) | 3.03412849 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 2.97517087 |
| 18 | Lipid accumulation in hepatocytes (HP:0006561) | 2.88647678 |
| 19 | True hermaphroditism (HP:0010459) | 2.86694096 |
| 20 | Abnormality of midbrain morphology (HP:0002418) | 2.85506554 |
| 21 | Molar tooth sign on MRI (HP:0002419) | 2.85506554 |
| 22 | Birth length less than 3rd percentile (HP:0003561) | 2.84478844 |
| 23 | Abnormality of the labia minora (HP:0012880) | 2.84432148 |
| 24 | Reticulocytopenia (HP:0001896) | 2.78216133 |
| 25 | Hepatic necrosis (HP:0002605) | 2.73357145 |
| 26 | Abnormality of the preputium (HP:0100587) | 2.60375053 |
| 27 | Cerebral edema (HP:0002181) | 2.55463499 |
| 28 | Abnormal number of erythroid precursors (HP:0012131) | 2.48245552 |
| 29 | Increased serum lactate (HP:0002151) | 2.47032435 |
| 30 | 3-Methylglutaconic aciduria (HP:0003535) | 2.42044966 |
| 31 | Nephronophthisis (HP:0000090) | 2.38085981 |
| 32 | Type I transferrin isoform profile (HP:0003642) | 2.36044794 |
| 33 | Medial flaring of the eyebrow (HP:0010747) | 2.30363405 |
| 34 | Sloping forehead (HP:0000340) | 2.29925325 |
| 35 | Small intestinal stenosis (HP:0012848) | 2.29886997 |
| 36 | Duodenal stenosis (HP:0100867) | 2.29886997 |
| 37 | Renal Fanconi syndrome (HP:0001994) | 2.28219491 |
| 38 | Ectopic kidney (HP:0000086) | 2.27340825 |
| 39 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.27087412 |
| 40 | Triphalangeal thumb (HP:0001199) | 2.26775463 |
| 41 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.25720236 |
| 42 | Abnormality of alanine metabolism (HP:0010916) | 2.25720236 |
| 43 | Hyperalaninemia (HP:0003348) | 2.25720236 |
| 44 | Clubbing of toes (HP:0100760) | 2.24333485 |
| 45 | Abnormal lung lobation (HP:0002101) | 2.22451523 |
| 46 | Methylmalonic acidemia (HP:0002912) | 2.17284153 |
| 47 | Absent thumb (HP:0009777) | 2.13111412 |
| 48 | Abnormality of the duodenum (HP:0002246) | 2.12618533 |
| 49 | Lactic acidosis (HP:0003128) | 2.12322015 |
| 50 | Bifid tongue (HP:0010297) | 2.11015744 |
| 51 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.09153309 |
| 52 | Abnormal protein glycosylation (HP:0012346) | 2.09153309 |
| 53 | Abnormal glycosylation (HP:0012345) | 2.09153309 |
| 54 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.09153309 |
| 55 | Sclerocornea (HP:0000647) | 2.08163201 |
| 56 | Abnormality of the renal medulla (HP:0100957) | 2.03962775 |
| 57 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.02604898 |
| 58 | Anencephaly (HP:0002323) | 2.01904332 |
| 59 | Absent radius (HP:0003974) | 2.00859483 |
| 60 | Abnormality of the pons (HP:0007361) | 1.98882695 |
| 61 | Supernumerary spleens (HP:0009799) | 1.98835610 |
| 62 | Abnormality of the renal cortex (HP:0011035) | 1.98599930 |
| 63 | Methylmalonic aciduria (HP:0012120) | 1.96942694 |
| 64 | Optic disc pallor (HP:0000543) | 1.94759030 |
| 65 | Preaxial hand polydactyly (HP:0001177) | 1.94639565 |
| 66 | Duplicated collecting system (HP:0000081) | 1.94347758 |
| 67 | Congenital primary aphakia (HP:0007707) | 1.91699558 |
| 68 | Abnormality of the carotid arteries (HP:0005344) | 1.91501049 |
| 69 | Leukodystrophy (HP:0002415) | 1.90967758 |
| 70 | Hyperglycinemia (HP:0002154) | 1.90132727 |
| 71 | Hypoplasia of the pons (HP:0012110) | 1.89991779 |
| 72 | Abnormal biliary tract physiology (HP:0012439) | 1.89637527 |
| 73 | Bile duct proliferation (HP:0001408) | 1.89637527 |
| 74 | Aplasia involving forearm bones (HP:0009822) | 1.88434842 |
| 75 | Absent forearm bone (HP:0003953) | 1.88434842 |
| 76 | Abnormality of serum amino acid levels (HP:0003112) | 1.87764084 |
| 77 | Abnormality of the renal collecting system (HP:0004742) | 1.87542557 |
| 78 | Abnormality of methionine metabolism (HP:0010901) | 1.87304370 |
| 79 | Respiratory failure (HP:0002878) | 1.86903074 |
| 80 | Intestinal atresia (HP:0011100) | 1.86533343 |
| 81 | Volvulus (HP:0002580) | 1.85581059 |
| 82 | Macrocytic anemia (HP:0001972) | 1.84734079 |
| 83 | Septo-optic dysplasia (HP:0100842) | 1.83689340 |
| 84 | Postaxial foot polydactyly (HP:0001830) | 1.83172329 |
| 85 | Glioma (HP:0009733) | 1.82296662 |
| 86 | Increased intramyocellular lipid droplets (HP:0012240) | 1.81052968 |
| 87 | Gait imbalance (HP:0002141) | 1.80190202 |
| 88 | Patellar aplasia (HP:0006443) | 1.78561498 |
| 89 | Cystic liver disease (HP:0006706) | 1.78126889 |
| 90 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.77946659 |
| 91 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.77946659 |
| 92 | Oligodactyly (hands) (HP:0001180) | 1.77228438 |
| 93 | Exercise intolerance (HP:0003546) | 1.76830614 |
| 94 | Nephrogenic diabetes insipidus (HP:0009806) | 1.76801949 |
| 95 | Genital tract atresia (HP:0001827) | 1.76022458 |
| 96 | Myelodysplasia (HP:0002863) | 1.75937261 |
| 97 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.74851572 |
| 98 | Dandy-Walker malformation (HP:0001305) | 1.73873970 |
| 99 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.72866514 |
| 100 | Astigmatism (HP:0000483) | 1.72692482 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 3.87037567 |
| 2 | ZAK | 3.65351708 |
| 3 | FRK | 3.28159159 |
| 4 | VRK2 | 2.99194749 |
| 5 | CDC7 | 2.94893306 |
| 6 | SRPK1 | 2.70250427 |
| 7 | PBK | 2.54763357 |
| 8 | BMPR1B | 2.50255630 |
| 9 | NUAK1 | 2.35544212 |
| 10 | WNK3 | 2.31963868 |
| 11 | VRK1 | 2.22558577 |
| 12 | BRSK2 | 2.22361529 |
| 13 | TTK | 2.20307880 |
| 14 | NEK1 | 2.02272795 |
| 15 | PLK4 | 2.01305613 |
| 16 | PLK3 | 2.01257105 |
| 17 | TRIM28 | 1.98409065 |
| 18 | STK16 | 1.91945689 |
| 19 | MST4 | 1.91057018 |
| 20 | TLK1 | 1.86723371 |
| 21 | TNIK | 1.85654617 |
| 22 | MKNK2 | 1.83082856 |
| 23 | NME1 | 1.82489191 |
| 24 | WEE1 | 1.82043899 |
| 25 | ACVR1B | 1.74762980 |
| 26 | EIF2AK1 | 1.67268006 |
| 27 | EIF2AK3 | 1.65353437 |
| 28 | MKNK1 | 1.51795781 |
| 29 | BCR | 1.48068769 |
| 30 | PLK1 | 1.43546089 |
| 31 | MAP4K2 | 1.41683202 |
| 32 | ATR | 1.30434980 |
| 33 | TSSK6 | 1.22714750 |
| 34 | DYRK2 | 1.15478770 |
| 35 | CHEK2 | 1.12654384 |
| 36 | BRSK1 | 1.11757465 |
| 37 | MAP3K4 | 1.06593040 |
| 38 | ADRBK2 | 1.01990538 |
| 39 | AURKB | 1.01601737 |
| 40 | STK3 | 1.00346165 |
| 41 | TAF1 | 0.99129830 |
| 42 | BCKDK | 0.97696190 |
| 43 | OXSR1 | 0.94771850 |
| 44 | GRK1 | 0.92568184 |
| 45 | PLK2 | 0.88651934 |
| 46 | NEK2 | 0.84604660 |
| 47 | STK38L | 0.84502099 |
| 48 | INSRR | 0.83527352 |
| 49 | PDK2 | 0.83455644 |
| 50 | CDK19 | 0.81039635 |
| 51 | ATM | 0.79012675 |
| 52 | CDK8 | 0.78501556 |
| 53 | MAPK13 | 0.78496642 |
| 54 | CSNK1G1 | 0.78443910 |
| 55 | CHEK1 | 0.76603912 |
| 56 | STK4 | 0.75030673 |
| 57 | NLK | 0.74692430 |
| 58 | EIF2AK2 | 0.74514135 |
| 59 | CASK | 0.70993046 |
| 60 | CSNK1A1L | 0.70479965 |
| 61 | CSNK1G3 | 0.68592628 |
| 62 | CCNB1 | 0.65750455 |
| 63 | CSNK1G2 | 0.60433294 |
| 64 | TGFBR1 | 0.59052819 |
| 65 | OBSCN | 0.58633471 |
| 66 | PAK3 | 0.54815749 |
| 67 | MAP3K12 | 0.54455513 |
| 68 | DYRK3 | 0.53117282 |
| 69 | RPS6KA5 | 0.52392240 |
| 70 | CLK1 | 0.51267401 |
| 71 | ERBB3 | 0.47295403 |
| 72 | CSNK2A2 | 0.46726403 |
| 73 | CSNK2A1 | 0.46615736 |
| 74 | EPHA4 | 0.46595507 |
| 75 | MELK | 0.45738758 |
| 76 | CDK1 | 0.44415807 |
| 77 | AURKA | 0.42551125 |
| 78 | STK39 | 0.42085148 |
| 79 | PINK1 | 0.41273064 |
| 80 | WNK4 | 0.41010459 |
| 81 | PASK | 0.40719983 |
| 82 | MAP2K7 | 0.39048136 |
| 83 | MARK3 | 0.38639332 |
| 84 | CDK2 | 0.38292702 |
| 85 | RPS6KB2 | 0.37781377 |
| 86 | AKT3 | 0.37728930 |
| 87 | CDK7 | 0.37304524 |
| 88 | ADRBK1 | 0.35936899 |
| 89 | CSNK1E | 0.35347105 |
| 90 | PRKCE | 0.34544137 |
| 91 | BRD4 | 0.34176058 |
| 92 | MUSK | 0.33148568 |
| 93 | PRKCI | 0.32762307 |
| 94 | PRKDC | 0.32070229 |
| 95 | PRKCG | 0.31877738 |
| 96 | PIM1 | 0.31482017 |
| 97 | TEC | 0.31214560 |
| 98 | STK24 | 0.30407491 |
| 99 | PRKACB | 0.29550886 |
| 100 | LATS1 | 0.29457062 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Mismatch repair_Homo sapiens_hsa03430 | 3.59340882 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.52361524 |
| 3 | Homologous recombination_Homo sapiens_hsa03440 | 3.44280799 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.37380115 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.16868961 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.13111513 |
| 7 | Ribosome_Homo sapiens_hsa03010 | 3.08200897 |
| 8 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.94171393 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.79084248 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.70602909 |
| 11 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.66722363 |
| 12 | Protein export_Homo sapiens_hsa03060 | 2.47202019 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.26900594 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.17471961 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 2.13420807 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.12326277 |
| 17 | RNA degradation_Homo sapiens_hsa03018 | 2.05481174 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 2.00106351 |
| 19 | Spliceosome_Homo sapiens_hsa03040 | 1.93942328 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.87432349 |
| 21 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.79436787 |
| 22 | Alzheimers disease_Homo sapiens_hsa05010 | 1.73874649 |
| 23 | Cell cycle_Homo sapiens_hsa04110 | 1.72575346 |
| 24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.72330609 |
| 25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.69265745 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.61903354 |
| 27 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.49034039 |
| 28 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.48872748 |
| 29 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.44604386 |
| 30 | Purine metabolism_Homo sapiens_hsa00230 | 1.41137525 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.32520026 |
| 32 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.31807594 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.28396692 |
| 34 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.21493104 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.11980272 |
| 36 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.09771916 |
| 37 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.09372801 |
| 38 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.02494908 |
| 39 | Phototransduction_Homo sapiens_hsa04744 | 1.01350864 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.96381042 |
| 41 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.94423639 |
| 42 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.90322837 |
| 43 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.89111934 |
| 44 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.88097075 |
| 45 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.85138091 |
| 46 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.84599747 |
| 47 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.83629931 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.80693785 |
| 49 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74349506 |
| 50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.73602112 |
| 51 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.67239969 |
| 52 | Peroxisome_Homo sapiens_hsa04146 | 0.62710315 |
| 53 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.62149809 |
| 54 | Sulfur relay system_Homo sapiens_hsa04122 | 0.59454019 |
| 55 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.59339715 |
| 56 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.55610537 |
| 57 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.55569750 |
| 58 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.54760161 |
| 59 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.54515150 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.52476428 |
| 61 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.52223511 |
| 62 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.51096705 |
| 63 | Lysine degradation_Homo sapiens_hsa00310 | 0.50717706 |
| 64 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.45123152 |
| 65 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.43395286 |
| 66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.41616880 |
| 67 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.41517589 |
| 68 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.40502098 |
| 69 | Taste transduction_Homo sapiens_hsa04742 | 0.40356129 |
| 70 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.39643784 |
| 71 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.38378364 |
| 72 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.37708438 |
| 73 | Nicotine addiction_Homo sapiens_hsa05033 | 0.37702806 |
| 74 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.37221016 |
| 75 | Olfactory transduction_Homo sapiens_hsa04740 | 0.35502487 |
| 76 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.33595134 |
| 77 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.33305439 |
| 78 | Carbon metabolism_Homo sapiens_hsa01200 | 0.31229016 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.29729292 |
| 80 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.29665937 |
| 81 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.28727313 |
| 82 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.27361103 |
| 83 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.26834845 |
| 84 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.26548182 |
| 85 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.26284504 |
| 86 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.26149812 |
| 87 | Alcoholism_Homo sapiens_hsa05034 | 0.26029683 |
| 88 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.25435378 |
| 89 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.25400959 |
| 90 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.24801910 |
| 91 | Circadian rhythm_Homo sapiens_hsa04710 | 0.24725644 |
| 92 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.24712979 |
| 93 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.23951720 |
| 94 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.23872548 |
| 95 | Retinol metabolism_Homo sapiens_hsa00830 | 0.23010859 |
| 96 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.21858281 |
| 97 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.21330437 |
| 98 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.21266298 |
| 99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.19392789 |
| 100 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.19361742 |

