COA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)4.65388194
2CENP-A containing nucleosome assembly (GO:0034080)4.52877172
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44223765
4DNA replication checkpoint (GO:0000076)4.31767386
5proteasome assembly (GO:0043248)4.21630039
6replication fork processing (GO:0031297)3.92266088
7regulation of mitotic spindle checkpoint (GO:1903504)3.85400494
8regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.85400494
9chaperone-mediated protein transport (GO:0072321)3.84062586
10histone exchange (GO:0043486)3.79915413
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.78594833
12ATP synthesis coupled proton transport (GO:0015986)3.78594833
13telomere maintenance via semi-conservative replication (GO:0032201)3.72542624
14kinetochore organization (GO:0051383)3.69836163
15DNA strand elongation involved in DNA replication (GO:0006271)3.68570251
16kinetochore assembly (GO:0051382)3.68462683
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64126206
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.62791199
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62590796
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62366200
21DNA double-strand break processing (GO:0000729)3.60038482
22* protein complex biogenesis (GO:0070271)3.51589702
23* mitochondrial respiratory chain complex assembly (GO:0033108)3.49777915
24regulation of mitochondrial translation (GO:0070129)3.49194761
25DNA strand elongation (GO:0022616)3.49102534
26establishment of integrated proviral latency (GO:0075713)3.46528520
27DNA replication-independent nucleosome organization (GO:0034724)3.45845946
28DNA replication-independent nucleosome assembly (GO:0006336)3.45845946
29pseudouridine synthesis (GO:0001522)3.45594670
30telomere maintenance via recombination (GO:0000722)3.35995326
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.33942723
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31775673
33* mitochondrial respiratory chain complex I assembly (GO:0032981)3.29284429
34* NADH dehydrogenase complex assembly (GO:0010257)3.29284429
35* mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29284429
36respiratory electron transport chain (GO:0022904)3.26666990
37mitotic recombination (GO:0006312)3.24951461
38peptidyl-histidine modification (GO:0018202)3.23280810
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20857623
40electron transport chain (GO:0022900)3.20835327
41resolution of meiotic recombination intermediates (GO:0000712)3.19452067
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15662343
43protein K6-linked ubiquitination (GO:0085020)3.14297277
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.12293275
45termination of RNA polymerase III transcription (GO:0006386)3.12293275
46maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11901774
47synapsis (GO:0007129)3.10148104
48recombinational repair (GO:0000725)3.09989246
49rRNA modification (GO:0000154)3.09742783
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.07933672
51spindle checkpoint (GO:0031577)3.07862478
52double-strand break repair via homologous recombination (GO:0000724)3.07122650
53mitotic sister chromatid segregation (GO:0000070)3.06580985
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06444900
55spliceosomal snRNP assembly (GO:0000387)3.04993196
56protein localization to kinetochore (GO:0034501)3.04429704
57mitotic metaphase plate congression (GO:0007080)3.03856045
58negative regulation of mitotic sister chromatid separation (GO:2000816)3.03404976
59negative regulation of sister chromatid segregation (GO:0033046)3.03404976
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03404976
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03404976
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03404976
63negative regulation of chromosome segregation (GO:0051985)3.02471713
64mitotic spindle checkpoint (GO:0071174)3.01906024
65DNA catabolic process, exonucleolytic (GO:0000738)3.01269608
66histone mRNA metabolic process (GO:0008334)3.01087330
67DNA replication-dependent nucleosome assembly (GO:0006335)2.97911649
68DNA replication-dependent nucleosome organization (GO:0034723)2.97911649
69DNA ligation (GO:0006266)2.95746792
70protein neddylation (GO:0045116)2.95577398
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94918976
72negative regulation of ligase activity (GO:0051352)2.94918976
73centriole replication (GO:0007099)2.94352599
74* respiratory chain complex IV assembly (GO:0008535)2.93315286
75ribosomal small subunit assembly (GO:0000028)2.89054182
76regulation of nuclear cell cycle DNA replication (GO:0033262)2.88951707
77sister chromatid segregation (GO:0000819)2.88464228
78purine nucleobase biosynthetic process (GO:0009113)2.88416864
79metaphase plate congression (GO:0051310)2.87571354
80mitotic spindle assembly checkpoint (GO:0007094)2.83595916
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81664095
82somatic hypermutation of immunoglobulin genes (GO:0016446)2.81664095
83RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79603285
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79603285
85spindle assembly checkpoint (GO:0071173)2.79279540
86telomere maintenance via telomere lengthening (GO:0010833)2.78975705
87transcription-coupled nucleotide-excision repair (GO:0006283)2.78499712
88nucleobase biosynthetic process (GO:0046112)2.78237452
89postreplication repair (GO:0006301)2.77400215
90maturation of 5.8S rRNA (GO:0000460)2.76329322
91regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.75400620
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.75400620
93* cytochrome complex assembly (GO:0017004)2.73457640
94regulation of sister chromatid segregation (GO:0033045)2.72501240
95regulation of mitotic sister chromatid separation (GO:0010965)2.72501240
96regulation of mitotic sister chromatid segregation (GO:0033047)2.72501240
97mitochondrial RNA metabolic process (GO:0000959)2.70246836
98meiotic chromosome segregation (GO:0045132)2.69943180
99tRNA processing (GO:0008033)2.68709469
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68529512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.93804563
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.53472128
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.84976640
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.83707654
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83415430
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47217548
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.25693030
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95512762
9ELK1_19687146_ChIP-ChIP_HELA_Human2.74361475
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69016308
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67711460
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.65237212
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.64785801
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61304825
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.59086943
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.59067697
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59044655
18ZNF274_21170338_ChIP-Seq_K562_Hela2.42848332
19VDR_23849224_ChIP-Seq_CD4+_Human2.41051192
20FOXP3_21729870_ChIP-Seq_TREG_Human2.19421073
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08164492
22EWS_26573619_Chip-Seq_HEK293_Human2.03593418
23VDR_22108803_ChIP-Seq_LS180_Human2.03131866
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96086712
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91322540
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88664802
27MYC_18940864_ChIP-ChIP_HL60_Human1.87841740
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87241959
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85885629
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84452029
31FUS_26573619_Chip-Seq_HEK293_Human1.83195283
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82616860
33IGF1R_20145208_ChIP-Seq_DFB_Human1.74414039
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.72983134
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.71721034
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69586607
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67953119
38DCP1A_22483619_ChIP-Seq_HELA_Human1.66242194
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.64748228
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64195251
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63460942
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56369028
43TTF2_22483619_ChIP-Seq_HELA_Human1.54673210
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.45554119
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45531120
46GABP_19822575_ChIP-Seq_HepG2_Human1.45379596
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44540657
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43016198
49IRF1_19129219_ChIP-ChIP_H3396_Human1.42819764
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42176108
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38670691
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34305200
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32788380
54TAF15_26573619_Chip-Seq_HEK293_Human1.32224315
55XRN2_22483619_ChIP-Seq_HELA_Human1.25713305
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.24369642
57P300_19829295_ChIP-Seq_ESCs_Human1.23270376
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21797128
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18381619
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17985022
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16348676
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15916856
63KDM5A_27292631_Chip-Seq_BREAST_Human1.12944206
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12486974
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10328361
66TP53_22573176_ChIP-Seq_HFKS_Human1.09659358
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08140745
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07496357
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07384061
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.06783377
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06430957
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06290287
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.05994262
74ER_23166858_ChIP-Seq_MCF-7_Human1.05966489
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05217516
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05053513
77GBX2_23144817_ChIP-Seq_PC3_Human1.04455070
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03828403
79AR_21909140_ChIP-Seq_LNCAP_Human1.03397929
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.03285226
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01680741
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00828948
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99766493
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.94661570
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93644695
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89160993
87CBP_20019798_ChIP-Seq_JUKART_Human0.89160993
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.88719540
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86675665
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85426998
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84574188
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83660558
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83323005
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82808041
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.82542045
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81800299
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80521255
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79455210
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78380687
100CIITA_25753668_ChIP-Seq_RAJI_Human0.75525251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.81012300
2MP0008058_abnormal_DNA_repair3.74085403
3MP0008057_abnormal_DNA_replication3.60172285
4MP0008877_abnormal_DNA_methylation3.21744717
5MP0003693_abnormal_embryo_hatching3.07681320
6MP0006292_abnormal_olfactory_placode3.04916701
7MP0003111_abnormal_nucleus_morphology2.82625590
8MP0004957_abnormal_blastocyst_morpholog2.61718120
9MP0003718_maternal_effect2.53511879
10MP0003077_abnormal_cell_cycle2.52844201
11MP0002102_abnormal_ear_morphology2.32780017
12MP0003136_yellow_coat_color2.20686777
13MP0002938_white_spotting2.15408655
14MP0001529_abnormal_vocalization2.04080466
15MP0008932_abnormal_embryonic_tissue2.03558326
16MP0009697_abnormal_copulation1.98285170
17MP0000372_irregular_coat_pigmentation1.95548476
18MP0003786_premature_aging1.87543305
19MP0008007_abnormal_cellular_replicative1.82432364
20MP0002163_abnormal_gland_morphology1.80146521
21MP0001293_anophthalmia1.78654781
22MP0000569_abnormal_digit_pigmentation1.73920113
23MP0006072_abnormal_retinal_apoptosis1.66646289
24MP0008995_early_reproductive_senescence1.62046757
25MP0003195_calcinosis1.54432406
26MP0006035_abnormal_mitochondrial_morpho1.53897816
27MP0003890_abnormal_embryonic-extraembry1.51931343
28MP0003646_muscle_fatigue1.49375970
29MP0010030_abnormal_orbit_morphology1.48048991
30MP0003787_abnormal_imprinting1.46127455
31MP0003567_abnormal_fetal_cardiomyocyte1.46078020
32MP0003121_genomic_imprinting1.40892276
33MP0003937_abnormal_limbs/digits/tail_de1.37649888
34MP0006036_abnormal_mitochondrial_physio1.36152017
35MP0004147_increased_porphyrin_level1.34410138
36MP0002210_abnormal_sex_determination1.33911436
37MP0002638_abnormal_pupillary_reflex1.28727867
38MP0003186_abnormal_redox_activity1.28715752
39MP0001929_abnormal_gametogenesis1.27588286
40MP0000631_abnormal_neuroendocrine_gland1.25715899
41MP0005253_abnormal_eye_physiology1.23239211
42MP0001346_abnormal_lacrimal_gland1.21705625
43MP0008789_abnormal_olfactory_epithelium1.20897233
44MP0002837_dystrophic_cardiac_calcinosis1.18953904
45MP0005551_abnormal_eye_electrophysiolog1.17526061
46MP0003806_abnormal_nucleotide_metabolis1.15952002
47MP0001984_abnormal_olfaction1.15611497
48MP0009379_abnormal_foot_pigmentation1.15120359
49MP0002653_abnormal_ependyma_morphology1.11527547
50MP0000653_abnormal_sex_gland1.10937841
51MP0000427_abnormal_hair_cycle1.10621415
52MP0001145_abnormal_male_reproductive1.08050513
53MP0002736_abnormal_nociception_after1.06739023
54MP0002751_abnormal_autonomic_nervous1.05363306
55MP0004142_abnormal_muscle_tone1.03513955
56MP0002234_abnormal_pharynx_morphology1.03357831
57MP0005174_abnormal_tail_pigmentation1.03027683
58MP0001286_abnormal_eye_development1.02098638
59MP0001697_abnormal_embryo_size1.01358566
60MP0002160_abnormal_reproductive_system1.00842921
61MP0005379_endocrine/exocrine_gland_phen1.00198067
62MP0003941_abnormal_skin_development0.99921131
63MP0000647_abnormal_sebaceous_gland0.98741243
64MP0005408_hypopigmentation0.98619182
65MP0002095_abnormal_skin_pigmentation0.98188128
66MP0003698_abnormal_male_reproductive0.97813618
67MP0001764_abnormal_homeostasis0.96965454
68MP0005395_other_phenotype0.93751296
69MP0005646_abnormal_pituitary_gland0.93270829
70MP0009046_muscle_twitch0.92161031
71MP0001119_abnormal_female_reproductive0.90904806
72MP0002233_abnormal_nose_morphology0.88846634
73MP0005075_abnormal_melanosome_morpholog0.88554238
74MP0004133_heterotaxia0.87737004
75MP0003119_abnormal_digestive_system0.86926705
76MP0000350_abnormal_cell_proliferation0.85538473
77MP0001672_abnormal_embryogenesis/_devel0.85470293
78MP0005380_embryogenesis_phenotype0.85470293
79MP0000049_abnormal_middle_ear0.84472732
80MP0004215_abnormal_myocardial_fiber0.83669498
81MP0005394_taste/olfaction_phenotype0.83514809
82MP0005499_abnormal_olfactory_system0.83514809
83MP0005389_reproductive_system_phenotype0.83502074
84MP0000358_abnormal_cell_content/0.83124474
85MP0002084_abnormal_developmental_patter0.82359416
86MP0001968_abnormal_touch/_nociception0.81382638
87MP0002697_abnormal_eye_size0.80554272
88MP0005391_vision/eye_phenotype0.80347395
89MP0002085_abnormal_embryonic_tissue0.80017698
90MP0001485_abnormal_pinna_reflex0.79928393
91MP0005084_abnormal_gallbladder_morpholo0.78714478
92MP0002088_abnormal_embryonic_growth/wei0.72714971
93MP0005187_abnormal_penis_morphology0.72466635
94MP0008872_abnormal_physiological_respon0.72453203
95MP0005645_abnormal_hypothalamus_physiol0.72018207
96MP0003984_embryonic_growth_retardation0.71626077
97MP0010307_abnormal_tumor_latency0.70489236
98MP0006276_abnormal_autonomic_nervous0.70478652
99MP0000313_abnormal_cell_death0.69213107
100MP0001324_abnormal_eye_pigmentation0.68601591

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.85588076
2Abnormal mitochondria in muscle tissue (HP:0008316)3.49614446
3Acute encephalopathy (HP:0006846)3.45228233
4Mitochondrial inheritance (HP:0001427)3.37668655
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35204384
6Increased CSF lactate (HP:0002490)3.35013787
7Pancreatic cysts (HP:0001737)3.31758820
8Progressive macrocephaly (HP:0004481)3.26456396
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.26387582
10Chromsome breakage (HP:0040012)3.17549040
11Colon cancer (HP:0003003)3.14032804
12Meckel diverticulum (HP:0002245)3.11654572
13Abnormality of chromosome stability (HP:0003220)3.11566049
14Pancreatic fibrosis (HP:0100732)3.08424638
15Hepatocellular necrosis (HP:0001404)3.03906218
16Abnormality of the ileum (HP:0001549)3.03412849
17Increased hepatocellular lipid droplets (HP:0006565)2.97517087
18Lipid accumulation in hepatocytes (HP:0006561)2.88647678
19True hermaphroditism (HP:0010459)2.86694096
20Abnormality of midbrain morphology (HP:0002418)2.85506554
21Molar tooth sign on MRI (HP:0002419)2.85506554
22Birth length less than 3rd percentile (HP:0003561)2.84478844
23Abnormality of the labia minora (HP:0012880)2.84432148
24Reticulocytopenia (HP:0001896)2.78216133
25Hepatic necrosis (HP:0002605)2.73357145
26Abnormality of the preputium (HP:0100587)2.60375053
27Cerebral edema (HP:0002181)2.55463499
28Abnormal number of erythroid precursors (HP:0012131)2.48245552
29Increased serum lactate (HP:0002151)2.47032435
303-Methylglutaconic aciduria (HP:0003535)2.42044966
31Nephronophthisis (HP:0000090)2.38085981
32Type I transferrin isoform profile (HP:0003642)2.36044794
33Medial flaring of the eyebrow (HP:0010747)2.30363405
34Sloping forehead (HP:0000340)2.29925325
35Small intestinal stenosis (HP:0012848)2.29886997
36Duodenal stenosis (HP:0100867)2.29886997
37Renal Fanconi syndrome (HP:0001994)2.28219491
38Ectopic kidney (HP:0000086)2.27340825
39Abnormality of cells of the erythroid lineage (HP:0012130)2.27087412
40Triphalangeal thumb (HP:0001199)2.26775463
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25720236
42Abnormality of alanine metabolism (HP:0010916)2.25720236
43Hyperalaninemia (HP:0003348)2.25720236
44Clubbing of toes (HP:0100760)2.24333485
45Abnormal lung lobation (HP:0002101)2.22451523
46Methylmalonic acidemia (HP:0002912)2.17284153
47Absent thumb (HP:0009777)2.13111412
48Abnormality of the duodenum (HP:0002246)2.12618533
49Lactic acidosis (HP:0003128)2.12322015
50Bifid tongue (HP:0010297)2.11015744
51Abnormal protein N-linked glycosylation (HP:0012347)2.09153309
52Abnormal protein glycosylation (HP:0012346)2.09153309
53Abnormal glycosylation (HP:0012345)2.09153309
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09153309
55Sclerocornea (HP:0000647)2.08163201
56Abnormality of the renal medulla (HP:0100957)2.03962775
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.02604898
58Anencephaly (HP:0002323)2.01904332
59Absent radius (HP:0003974)2.00859483
60Abnormality of the pons (HP:0007361)1.98882695
61Supernumerary spleens (HP:0009799)1.98835610
62Abnormality of the renal cortex (HP:0011035)1.98599930
63Methylmalonic aciduria (HP:0012120)1.96942694
64Optic disc pallor (HP:0000543)1.94759030
65Preaxial hand polydactyly (HP:0001177)1.94639565
66Duplicated collecting system (HP:0000081)1.94347758
67Congenital primary aphakia (HP:0007707)1.91699558
68Abnormality of the carotid arteries (HP:0005344)1.91501049
69Leukodystrophy (HP:0002415)1.90967758
70Hyperglycinemia (HP:0002154)1.90132727
71Hypoplasia of the pons (HP:0012110)1.89991779
72Abnormal biliary tract physiology (HP:0012439)1.89637527
73Bile duct proliferation (HP:0001408)1.89637527
74Aplasia involving forearm bones (HP:0009822)1.88434842
75Absent forearm bone (HP:0003953)1.88434842
76Abnormality of serum amino acid levels (HP:0003112)1.87764084
77Abnormality of the renal collecting system (HP:0004742)1.87542557
78Abnormality of methionine metabolism (HP:0010901)1.87304370
79Respiratory failure (HP:0002878)1.86903074
80Intestinal atresia (HP:0011100)1.86533343
81Volvulus (HP:0002580)1.85581059
82Macrocytic anemia (HP:0001972)1.84734079
83Septo-optic dysplasia (HP:0100842)1.83689340
84Postaxial foot polydactyly (HP:0001830)1.83172329
85Glioma (HP:0009733)1.82296662
86Increased intramyocellular lipid droplets (HP:0012240)1.81052968
87Gait imbalance (HP:0002141)1.80190202
88Patellar aplasia (HP:0006443)1.78561498
89Cystic liver disease (HP:0006706)1.78126889
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77946659
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77946659
92Oligodactyly (hands) (HP:0001180)1.77228438
93Exercise intolerance (HP:0003546)1.76830614
94Nephrogenic diabetes insipidus (HP:0009806)1.76801949
95Genital tract atresia (HP:0001827)1.76022458
96Myelodysplasia (HP:0002863)1.75937261
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.74851572
98Dandy-Walker malformation (HP:0001305)1.73873970
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72866514
100Astigmatism (HP:0000483)1.72692482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.87037567
2ZAK3.65351708
3FRK3.28159159
4VRK22.99194749
5CDC72.94893306
6SRPK12.70250427
7PBK2.54763357
8BMPR1B2.50255630
9NUAK12.35544212
10WNK32.31963868
11VRK12.22558577
12BRSK22.22361529
13TTK2.20307880
14NEK12.02272795
15PLK42.01305613
16PLK32.01257105
17TRIM281.98409065
18STK161.91945689
19MST41.91057018
20TLK11.86723371
21TNIK1.85654617
22MKNK21.83082856
23NME11.82489191
24WEE11.82043899
25ACVR1B1.74762980
26EIF2AK11.67268006
27EIF2AK31.65353437
28MKNK11.51795781
29BCR1.48068769
30PLK11.43546089
31MAP4K21.41683202
32ATR1.30434980
33TSSK61.22714750
34DYRK21.15478770
35CHEK21.12654384
36BRSK11.11757465
37MAP3K41.06593040
38ADRBK21.01990538
39AURKB1.01601737
40STK31.00346165
41TAF10.99129830
42BCKDK0.97696190
43OXSR10.94771850
44GRK10.92568184
45PLK20.88651934
46NEK20.84604660
47STK38L0.84502099
48INSRR0.83527352
49PDK20.83455644
50CDK190.81039635
51ATM0.79012675
52CDK80.78501556
53MAPK130.78496642
54CSNK1G10.78443910
55CHEK10.76603912
56STK40.75030673
57NLK0.74692430
58EIF2AK20.74514135
59CASK0.70993046
60CSNK1A1L0.70479965
61CSNK1G30.68592628
62CCNB10.65750455
63CSNK1G20.60433294
64TGFBR10.59052819
65OBSCN0.58633471
66PAK30.54815749
67MAP3K120.54455513
68DYRK30.53117282
69RPS6KA50.52392240
70CLK10.51267401
71ERBB30.47295403
72CSNK2A20.46726403
73CSNK2A10.46615736
74EPHA40.46595507
75MELK0.45738758
76CDK10.44415807
77AURKA0.42551125
78STK390.42085148
79PINK10.41273064
80WNK40.41010459
81PASK0.40719983
82MAP2K70.39048136
83MARK30.38639332
84CDK20.38292702
85RPS6KB20.37781377
86AKT30.37728930
87CDK70.37304524
88ADRBK10.35936899
89CSNK1E0.35347105
90PRKCE0.34544137
91BRD40.34176058
92MUSK0.33148568
93PRKCI0.32762307
94PRKDC0.32070229
95PRKCG0.31877738
96PIM10.31482017
97TEC0.31214560
98STK240.30407491
99PRKACB0.29550886
100LATS10.29457062

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.59340882
2Proteasome_Homo sapiens_hsa030503.52361524
3Homologous recombination_Homo sapiens_hsa034403.44280799
4DNA replication_Homo sapiens_hsa030303.37380115
5Oxidative phosphorylation_Homo sapiens_hsa001903.16868961
6RNA polymerase_Homo sapiens_hsa030203.13111513
7Ribosome_Homo sapiens_hsa030103.08200897
8Non-homologous end-joining_Homo sapiens_hsa034502.94171393
9Parkinsons disease_Homo sapiens_hsa050122.79084248
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70602909
11Fanconi anemia pathway_Homo sapiens_hsa034602.66722363
12Protein export_Homo sapiens_hsa030602.47202019
13Nucleotide excision repair_Homo sapiens_hsa034202.26900594
14Huntingtons disease_Homo sapiens_hsa050162.17471961
15Base excision repair_Homo sapiens_hsa034102.13420807
16One carbon pool by folate_Homo sapiens_hsa006702.12326277
17RNA degradation_Homo sapiens_hsa030182.05481174
18Basal transcription factors_Homo sapiens_hsa030222.00106351
19Spliceosome_Homo sapiens_hsa030401.93942328
20RNA transport_Homo sapiens_hsa030131.87432349
21Pyrimidine metabolism_Homo sapiens_hsa002401.79436787
22Alzheimers disease_Homo sapiens_hsa050101.73874649
23Cell cycle_Homo sapiens_hsa041101.72575346
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72330609
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69265745
26Propanoate metabolism_Homo sapiens_hsa006401.61903354
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49034039
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48872748
29Selenocompound metabolism_Homo sapiens_hsa004501.44604386
30Purine metabolism_Homo sapiens_hsa002301.41137525
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.32520026
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31807594
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28396692
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21493104
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11980272
36Cardiac muscle contraction_Homo sapiens_hsa042601.09771916
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09372801
38Pyruvate metabolism_Homo sapiens_hsa006201.02494908
39Phototransduction_Homo sapiens_hsa047441.01350864
40Folate biosynthesis_Homo sapiens_hsa007900.96381042
41Butanoate metabolism_Homo sapiens_hsa006500.94423639
42Fatty acid elongation_Homo sapiens_hsa000620.90322837
43Nitrogen metabolism_Homo sapiens_hsa009100.89111934
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88097075
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85138091
46p53 signaling pathway_Homo sapiens_hsa041150.84599747
47mRNA surveillance pathway_Homo sapiens_hsa030150.83629931
48Oocyte meiosis_Homo sapiens_hsa041140.80693785
49Metabolic pathways_Homo sapiens_hsa011000.74349506
50Glutathione metabolism_Homo sapiens_hsa004800.73602112
51Steroid biosynthesis_Homo sapiens_hsa001000.67239969
52Peroxisome_Homo sapiens_hsa041460.62710315
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62149809
54Sulfur relay system_Homo sapiens_hsa041220.59454019
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59339715
56Vitamin B6 metabolism_Homo sapiens_hsa007500.55610537
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55569750
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54760161
59Tryptophan metabolism_Homo sapiens_hsa003800.54515150
60N-Glycan biosynthesis_Homo sapiens_hsa005100.52476428
61Linoleic acid metabolism_Homo sapiens_hsa005910.52223511
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51096705
63Lysine degradation_Homo sapiens_hsa003100.50717706
64Regulation of autophagy_Homo sapiens_hsa041400.45123152
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43395286
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41616880
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41517589
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.40502098
69Taste transduction_Homo sapiens_hsa047420.40356129
70Systemic lupus erythematosus_Homo sapiens_hsa053220.39643784
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38378364
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37708438
73Nicotine addiction_Homo sapiens_hsa050330.37702806
74Basal cell carcinoma_Homo sapiens_hsa052170.37221016
75Olfactory transduction_Homo sapiens_hsa047400.35502487
76Biosynthesis of amino acids_Homo sapiens_hsa012300.33595134
77Vitamin digestion and absorption_Homo sapiens_hsa049770.33305439
78Carbon metabolism_Homo sapiens_hsa012000.31229016
79beta-Alanine metabolism_Homo sapiens_hsa004100.29729292
80Ether lipid metabolism_Homo sapiens_hsa005650.29665937
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28727313
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27361103
83Fatty acid metabolism_Homo sapiens_hsa012120.26834845
84Epstein-Barr virus infection_Homo sapiens_hsa051690.26548182
85Sulfur metabolism_Homo sapiens_hsa009200.26284504
86Chemical carcinogenesis_Homo sapiens_hsa052040.26149812
87Alcoholism_Homo sapiens_hsa050340.26029683
88Caffeine metabolism_Homo sapiens_hsa002320.25435378
89TGF-beta signaling pathway_Homo sapiens_hsa043500.25400959
90Hedgehog signaling pathway_Homo sapiens_hsa043400.24801910
91Circadian rhythm_Homo sapiens_hsa047100.24725644
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24712979
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23951720
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23872548
95Retinol metabolism_Homo sapiens_hsa008300.23010859
96Fatty acid degradation_Homo sapiens_hsa000710.21858281
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21330437
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21266298
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.19392789
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19361742

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