COA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.73337037
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.21968774
3ATP synthesis coupled proton transport (GO:0015986)8.21968774
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.07298963
5respiratory electron transport chain (GO:0022904)7.14915322
6electron transport chain (GO:0022900)6.99328082
7chaperone-mediated protein transport (GO:0072321)5.58302051
8* protein complex biogenesis (GO:0070271)5.27151538
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.22813788
10mitochondrial respiratory chain complex I assembly (GO:0032981)5.22813788
11NADH dehydrogenase complex assembly (GO:0010257)5.22813788
12protein neddylation (GO:0045116)5.13860623
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.78916344
14* mitochondrial respiratory chain complex assembly (GO:0033108)4.75738941
15hydrogen ion transmembrane transport (GO:1902600)4.66617412
16ATP biosynthetic process (GO:0006754)4.43674174
17purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.35466936
18purine nucleoside triphosphate biosynthetic process (GO:0009145)4.28408634
19energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.22582574
20ATP hydrolysis coupled proton transport (GO:0015991)4.22582574
21proton transport (GO:0015992)4.15773765
22GTP biosynthetic process (GO:0006183)4.06741603
23hydrogen transport (GO:0006818)4.06564692
24oxidative phosphorylation (GO:0006119)4.02475626
25inner mitochondrial membrane organization (GO:0007007)3.89298271
26regulation of oxidative phosphorylation (GO:0002082)3.87835095
27ribonucleoside triphosphate biosynthetic process (GO:0009201)3.80705701
28cullin deneddylation (GO:0010388)3.73484745
29water-soluble vitamin biosynthetic process (GO:0042364)3.73041909
30proteasome assembly (GO:0043248)3.70020669
31protein targeting to mitochondrion (GO:0006626)3.62409807
32establishment of protein localization to mitochondrion (GO:0072655)3.54637009
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53261127
34dopamine transport (GO:0015872)3.48298749
35rRNA modification (GO:0000154)3.45688162
36guanosine-containing compound biosynthetic process (GO:1901070)3.42727921
37protein deneddylation (GO:0000338)3.42009834
38transferrin transport (GO:0033572)3.36297342
39nucleoside triphosphate biosynthetic process (GO:0009142)3.36125120
40protein localization to mitochondrion (GO:0070585)3.32558324
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.29900927
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.29900927
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.29900927
44* cytochrome complex assembly (GO:0017004)3.27644024
45UTP biosynthetic process (GO:0006228)3.26306263
46protein-cofactor linkage (GO:0018065)3.25308067
47cotranslational protein targeting to membrane (GO:0006613)3.24731758
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24519845
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24519845
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23961629
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.23685315
52signal peptide processing (GO:0006465)3.23242428
53* respiratory chain complex IV assembly (GO:0008535)3.22027705
54regulation of cellular amino acid metabolic process (GO:0006521)3.21147101
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15427693
56platelet dense granule organization (GO:0060155)3.15146926
57protein targeting to ER (GO:0045047)3.15098921
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15026068
59signal transduction involved in DNA damage checkpoint (GO:0072422)3.13568307
60signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13568307
61signal transduction involved in cell cycle checkpoint (GO:0072395)3.11338860
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09561886
63aerobic respiration (GO:0009060)3.09372069
64protein localization to endoplasmic reticulum (GO:0070972)3.08396832
65trivalent inorganic cation transport (GO:0072512)3.08209234
66ferric iron transport (GO:0015682)3.08209234
67mitochondrial transport (GO:0006839)3.06835712
68DNA damage response, detection of DNA damage (GO:0042769)3.05776583
69sequestering of actin monomers (GO:0042989)3.04397158
70pseudouridine synthesis (GO:0001522)3.03770076
71establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99875876
72protein maturation by protein folding (GO:0022417)2.96985395
73GDP-mannose metabolic process (GO:0019673)2.96789952
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96430737
75* regulation of mitochondrial translation (GO:0070129)2.95487138
76presynaptic membrane assembly (GO:0097105)2.95261806
77positive regulation of ligase activity (GO:0051351)2.94073752
78aldehyde catabolic process (GO:0046185)2.93274749
79establishment of viral latency (GO:0019043)2.92416903
80establishment of integrated proviral latency (GO:0075713)2.89920019
81intracellular protein transmembrane import (GO:0044743)2.89122200
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.88714303
83termination of RNA polymerase III transcription (GO:0006386)2.88714303
84phagosome maturation (GO:0090382)2.88580495
85DNA deamination (GO:0045006)2.88424538
86regulation of cellular respiration (GO:0043457)2.86542832
87mannosylation (GO:0097502)2.85968952
88viral transcription (GO:0019083)2.85644586
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84790462
90CTP metabolic process (GO:0046036)2.84624006
91CTP biosynthetic process (GO:0006241)2.84624006
92UTP metabolic process (GO:0046051)2.84621062
93nucleoside diphosphate phosphorylation (GO:0006165)2.84448575
94translation (GO:0006412)2.84232401
95ribosomal small subunit assembly (GO:0000028)2.84184378
96NADH metabolic process (GO:0006734)2.81191884
97peptidyl-histidine modification (GO:0018202)2.80586833
98ribosomal small subunit biogenesis (GO:0042274)2.79986501
99regulation of catecholamine metabolic process (GO:0042069)2.79561995
100regulation of dopamine metabolic process (GO:0042053)2.79561995
101positive regulation of mitochondrial fission (GO:0090141)2.77066810
102metallo-sulfur cluster assembly (GO:0031163)2.76650577
103iron-sulfur cluster assembly (GO:0016226)2.76650577
104translational termination (GO:0006415)2.75278483
105presynaptic membrane organization (GO:0097090)2.74957648
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73847926
107protein localization to cilium (GO:0061512)2.73633546
108neuron cell-cell adhesion (GO:0007158)2.72571101
109negative regulation of ligase activity (GO:0051352)2.71252230
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71252230
111DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.70336800
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.68761555
113substantia nigra development (GO:0021762)2.68689102
1147-methylguanosine mRNA capping (GO:0006370)2.67370142
115regulation of cellular amine metabolic process (GO:0033238)2.67243055
116spliceosomal snRNP assembly (GO:0000387)2.65835935
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64518853
118L-phenylalanine catabolic process (GO:0006559)2.64518853
119generation of precursor metabolites and energy (GO:0006091)2.63455317
120RNA capping (GO:0036260)2.62014292
1217-methylguanosine RNA capping (GO:0009452)2.62014292
122signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61735275
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61735275
124negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.60789588
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60344792
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.60188652
127regulation of hexokinase activity (GO:1903299)2.57848762
128regulation of glucokinase activity (GO:0033131)2.57848762
129regulation of ligase activity (GO:0051340)2.57495961
130chromatin remodeling at centromere (GO:0031055)2.56416691
131DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.54726777
132rRNA methylation (GO:0031167)2.53954100
133DNA double-strand break processing (GO:0000729)2.53775285
134purine nucleoside monophosphate biosynthetic process (GO:0009127)2.51805921
135purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.51805921
136C-terminal protein lipidation (GO:0006501)2.49697258
137deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47567403
138positive regulation of cell cycle arrest (GO:0071158)2.46311064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37654317
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.79176501
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61172159
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.55822582
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.42023577
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41135901
7EZH2_22144423_ChIP-Seq_EOC_Human3.33593606
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.02072722
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97118575
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94065050
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.93880764
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88718205
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.76976555
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48767136
15GBX2_23144817_ChIP-Seq_PC3_Human2.48004041
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46980885
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35712039
18TAF15_26573619_Chip-Seq_HEK293_Human2.25865570
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.18156701
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16776586
21ZNF274_21170338_ChIP-Seq_K562_Hela2.13513648
22VDR_22108803_ChIP-Seq_LS180_Human1.97296046
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92973341
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.84876609
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.80435149
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70377100
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69991475
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65444297
29DCP1A_22483619_ChIP-Seq_HELA_Human1.59884390
30VDR_23849224_ChIP-Seq_CD4+_Human1.59251672
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58337427
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58049948
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48821001
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48186770
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47916924
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47597731
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47251270
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46314303
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46088293
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45631465
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45264478
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45147611
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44832994
44ELK1_19687146_ChIP-ChIP_HELA_Human1.42365852
45REST_21632747_ChIP-Seq_MESCs_Mouse1.41107927
46EWS_26573619_Chip-Seq_HEK293_Human1.40960949
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.40922102
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.39358598
49FUS_26573619_Chip-Seq_HEK293_Human1.38205149
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37204104
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35171569
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34489535
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32282701
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.30477836
55FOXP3_21729870_ChIP-Seq_TREG_Human1.29328626
56TP53_22573176_ChIP-Seq_HFKS_Human1.29155371
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28659055
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27966244
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27372892
60IRF1_19129219_ChIP-ChIP_H3396_Human1.26513841
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25097331
62CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23874411
63IGF1R_20145208_ChIP-Seq_DFB_Human1.23187782
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22901887
65P300_19829295_ChIP-Seq_ESCs_Human1.22833605
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19215745
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.19109740
68TTF2_22483619_ChIP-Seq_HELA_Human1.17965355
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14765816
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13995628
71GABP_19822575_ChIP-Seq_HepG2_Human1.11432093
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10748641
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10216382
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09942792
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09264233
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08764216
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07900816
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.06814527
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.06640293
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05370586
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05238206
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05208576
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05056798
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05004291
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.05004291
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04328451
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04133038
88ER_23166858_ChIP-Seq_MCF-7_Human1.03611414
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.03298041
90SOX2_19829295_ChIP-Seq_ESCs_Human1.00805981
91NANOG_19829295_ChIP-Seq_ESCs_Human1.00805981
92REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99377811
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97766101
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.95758058
95MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95577543
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95219206
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95173969
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95049671
99XRN2_22483619_ChIP-Seq_HELA_Human0.94669748
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94114432
101AR_20517297_ChIP-Seq_VCAP_Human0.93982880
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93574093
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93301971
104CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93300563
105HTT_18923047_ChIP-ChIP_STHdh_Human0.92738261
106MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92073437
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90225897
108MYC_18940864_ChIP-ChIP_HL60_Human0.89306640
109ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89081294
110RNF2_27304074_Chip-Seq_NSC_Mouse0.87309960
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85901336
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85679332
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85605935
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85562069
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85428864
116EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85231243
117SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85230446
118JUN_21703547_ChIP-Seq_K562_Human0.85191041
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85171854
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.85034767
121NCOR_22424771_ChIP-Seq_293T_Human0.84700706
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84553852
123BCAT_22108803_ChIP-Seq_LS180_Human0.84519811
124MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83788570
125ERG_20517297_ChIP-Seq_VCAP_Human0.82906301
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.82406627
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82082092
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81437897
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81187885
130KDM5A_27292631_Chip-Seq_BREAST_Human0.77520875
131GATA3_21878914_ChIP-Seq_MCF-7_Human0.71868260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.32854912
2MP0001529_abnormal_vocalization3.83475751
3MP0009379_abnormal_foot_pigmentation3.06707549
4MP0006276_abnormal_autonomic_nervous2.94517041
5MP0002837_dystrophic_cardiac_calcinosis2.79687577
6MP0001905_abnormal_dopamine_level2.74811239
7MP0002736_abnormal_nociception_after2.57626489
8MP0001968_abnormal_touch/_nociception2.55206434
9MP0002876_abnormal_thyroid_physiology2.51319829
10MP0010386_abnormal_urinary_bladder2.43239645
11MP0001986_abnormal_taste_sensitivity2.25633808
12MP0003011_delayed_dark_adaptation2.21616764
13MP0008877_abnormal_DNA_methylation2.21259016
14MP0002064_seizures2.19967689
15MP0002822_catalepsy2.19538026
16MP0002272_abnormal_nervous_system2.15033160
17MP0009745_abnormal_behavioral_response2.14592771
18MP0002735_abnormal_chemical_nociception2.14313163
19MP0006036_abnormal_mitochondrial_physio2.14205912
20MP0002938_white_spotting2.13947399
21MP0008058_abnormal_DNA_repair2.13368674
22MP0009046_muscle_twitch2.07022881
23MP0003635_abnormal_synaptic_transmissio2.05777835
24MP0006292_abnormal_olfactory_placode2.05259511
25MP0002734_abnormal_mechanical_nocicepti2.00452692
26MP0004270_analgesia2.00225664
27MP0004142_abnormal_muscle_tone1.98958976
28MP0002102_abnormal_ear_morphology1.96287829
29MP0001188_hyperpigmentation1.92593254
30MP0002163_abnormal_gland_morphology1.91771154
31MP0003122_maternal_imprinting1.88813756
32MP0005379_endocrine/exocrine_gland_phen1.87572465
33MP0005645_abnormal_hypothalamus_physiol1.85426383
34MP0002572_abnormal_emotion/affect_behav1.84268752
35MP0008875_abnormal_xenobiotic_pharmacok1.83539002
36MP0004043_abnormal_pH_regulation1.82776413
37MP0003718_maternal_effect1.76306096
38MP0000013_abnormal_adipose_tissue1.75203991
39MP0005646_abnormal_pituitary_gland1.74478953
40MP0002638_abnormal_pupillary_reflex1.72710097
41MP0001984_abnormal_olfaction1.71703999
42MP0001970_abnormal_pain_threshold1.71175470
43MP0006035_abnormal_mitochondrial_morpho1.69822821
44MP0002067_abnormal_sensory_capabilities1.67845884
45MP0001440_abnormal_grooming_behavior1.67151244
46MP0002733_abnormal_thermal_nociception1.64687569
47MP0005423_abnormal_somatic_nervous1.64007526
48MP0002063_abnormal_learning/memory/cond1.62611913
49MP0003786_premature_aging1.60642497
50MP0004859_abnormal_synaptic_plasticity1.54316121
51MP0001501_abnormal_sleep_pattern1.53770867
52MP0005386_behavior/neurological_phenoty1.51230712
53MP0004924_abnormal_behavior1.51230712
54MP0003121_genomic_imprinting1.48513898
55MP0002139_abnormal_hepatobiliary_system1.46999813
56MP0005171_absent_coat_pigmentation1.46704703
57MP0003195_calcinosis1.44420647
58MP0005332_abnormal_amino_acid1.42541047
59MP0001664_abnormal_digestion1.40799811
60MP0001486_abnormal_startle_reflex1.36520802
61MP0006072_abnormal_retinal_apoptosis1.36152461
62MP0004133_heterotaxia1.35423294
63MP0004147_increased_porphyrin_level1.31638478
64MP0002184_abnormal_innervation1.19853628
65MP0005084_abnormal_gallbladder_morpholo1.16556104
66MP0009697_abnormal_copulation1.16344501
67MP0000372_irregular_coat_pigmentation1.15342724
68MP0002557_abnormal_social/conspecific_i1.13702882
69MP0003693_abnormal_embryo_hatching1.13058797
70MP0002090_abnormal_vision1.11837753
71MP0001485_abnormal_pinna_reflex1.10455621
72MP0004019_abnormal_vitamin_homeostasis1.10389294
73MP0008872_abnormal_physiological_respon1.09986202
74MP0003136_yellow_coat_color1.08869914
75MP0005551_abnormal_eye_electrophysiolog1.08772391
76MP0008995_early_reproductive_senescence1.07287942
77MP0002653_abnormal_ependyma_morphology1.07233551
78MP0001756_abnormal_urination1.06591641
79MP0005075_abnormal_melanosome_morpholog1.05215636
80MP0003787_abnormal_imprinting1.05186234
81MP0000516_abnormal_urinary_system1.04630117
82MP0005367_renal/urinary_system_phenotyp1.04630117
83MP0002751_abnormal_autonomic_nervous1.04402200
84MP0005636_abnormal_mineral_homeostasis1.02276663
85MP0005535_abnormal_body_temperature1.01548996
86MP0005085_abnormal_gallbladder_physiolo1.01310473
87MP0002229_neurodegeneration1.00096698
88MP0002277_abnormal_respiratory_mucosa0.99536773
89MP0002066_abnormal_motor_capabilities/c0.99268381
90MP0000778_abnormal_nervous_system0.97963371
91MP0003186_abnormal_redox_activity0.94619404
92MP0004215_abnormal_myocardial_fiber0.93685976
93MP0005409_darkened_coat_color0.93547272
94MP0001963_abnormal_hearing_physiology0.93380908
95MP0009780_abnormal_chondrocyte_physiolo0.93012697
96MP0002693_abnormal_pancreas_physiology0.92767249
97MP0001764_abnormal_homeostasis0.92490358
98MP0005253_abnormal_eye_physiology0.92450778
99MP0005365_abnormal_bile_salt0.91970161
100MP0003879_abnormal_hair_cell0.89578213
101MP0010094_abnormal_chromosome_stability0.89357778
102MP0001502_abnormal_circadian_rhythm0.88959620
103MP0003806_abnormal_nucleotide_metabolis0.88426413
104MP0000538_abnormal_urinary_bladder0.88176676
105MP0005408_hypopigmentation0.88000663
106MP0004742_abnormal_vestibular_system0.86770224
107MP0004145_abnormal_muscle_electrophysio0.86714860
108MP0001293_anophthalmia0.86365840
109MP0001944_abnormal_pancreas_morphology0.85897295
110MP0008004_abnormal_stomach_pH0.85736571
111MP0003283_abnormal_digestive_organ0.85086886
112MP0003938_abnormal_ear_development0.84801768
113MP0008789_abnormal_olfactory_epithelium0.82327371
114MP0002095_abnormal_skin_pigmentation0.82258829
115MP0002882_abnormal_neuron_morphology0.82191971
116MP0004957_abnormal_blastocyst_morpholog0.81744721
117MP0005499_abnormal_olfactory_system0.81023655
118MP0005394_taste/olfaction_phenotype0.81023655
119MP0010329_abnormal_lipoprotein_level0.80453650
120MP0004036_abnormal_muscle_relaxation0.79399046
121MP0003329_amyloid_beta_deposits0.78476046
122MP0000026_abnormal_inner_ear0.78182652
123MP0000749_muscle_degeneration0.76904252
124MP0000631_abnormal_neuroendocrine_gland0.76664188
125MP0005389_reproductive_system_phenotype0.76469859
126MP0003137_abnormal_impulse_conducting0.75739811
127MP0002160_abnormal_reproductive_system0.75697767
128MP0000230_abnormal_systemic_arterial0.74103437
129MP0002909_abnormal_adrenal_gland0.74094340
130MP0001727_abnormal_embryo_implantation0.74034354
131MP0002234_abnormal_pharynx_morphology0.72592027
132MP0008569_lethality_at_weaning0.72350034
133MP0002069_abnormal_eating/drinking_beha0.71846250
134MP0000955_abnormal_spinal_cord0.71150710
135MP0000751_myopathy0.71134701
136MP0003123_paternal_imprinting0.68717894

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.46243125
2Abnormal mitochondria in muscle tissue (HP:0008316)6.94881808
3Mitochondrial inheritance (HP:0001427)6.74510688
4Progressive macrocephaly (HP:0004481)6.29576652
5Acute encephalopathy (HP:0006846)6.21995838
6Hepatocellular necrosis (HP:0001404)5.84806927
7Increased CSF lactate (HP:0002490)5.71553017
8Hepatic necrosis (HP:0002605)5.12058789
9Increased hepatocellular lipid droplets (HP:0006565)5.05721970
10Lipid accumulation in hepatocytes (HP:0006561)4.53967514
11Renal Fanconi syndrome (HP:0001994)4.41947522
12Cerebral edema (HP:0002181)4.14799383
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.04281499
14Increased intramyocellular lipid droplets (HP:0012240)3.95621479
15Respiratory failure (HP:0002878)3.92259486
16Lactic acidosis (HP:0003128)3.78710962
17Exercise intolerance (HP:0003546)3.78075990
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.75147400
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.75147400
20Optic disc pallor (HP:0000543)3.74221813
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.63066569
22Increased serum lactate (HP:0002151)3.57206970
23Leukodystrophy (HP:0002415)3.56762619
24Increased serum pyruvate (HP:0003542)3.53477412
25Abnormality of glycolysis (HP:0004366)3.53477412
263-Methylglutaconic aciduria (HP:0003535)3.49848026
27Increased muscle lipid content (HP:0009058)3.33979251
28Exertional dyspnea (HP:0002875)3.25152067
29Neuroendocrine neoplasm (HP:0100634)3.23362178
30Pheochromocytoma (HP:0002666)3.20961417
31Abnormality of renal resorption (HP:0011038)3.10330024
32Hypothermia (HP:0002045)2.87751487
33Focal motor seizures (HP:0011153)2.80076047
34Respiratory difficulties (HP:0002880)2.78322646
35Emotional lability (HP:0000712)2.70693367
36CNS demyelination (HP:0007305)2.69965638
37Pancreatic cysts (HP:0001737)2.63675970
38Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.61766809
39Glycosuria (HP:0003076)2.59759614
40Abnormality of urine glucose concentration (HP:0011016)2.59759614
41Abnormality of the labia minora (HP:0012880)2.58980614
42Hyperphosphaturia (HP:0003109)2.58061798
43Pancreatic fibrosis (HP:0100732)2.56826929
44Medial flaring of the eyebrow (HP:0010747)2.55963823
45Hyperglycinemia (HP:0002154)2.54203290
46True hermaphroditism (HP:0010459)2.48801152
47X-linked dominant inheritance (HP:0001423)2.48520942
48Myokymia (HP:0002411)2.45343766
49Abnormality of midbrain morphology (HP:0002418)2.41986757
50Molar tooth sign on MRI (HP:0002419)2.41986757
51Abnormality of cells of the erythroid lineage (HP:0012130)2.38216452
52Atonic seizures (HP:0010819)2.36725686
53Gait imbalance (HP:0002141)2.34980487
54Abnormal pupillary function (HP:0007686)2.32450241
55Congenital, generalized hypertrichosis (HP:0004540)2.29540097
56Congenital primary aphakia (HP:0007707)2.29151929
57Poor suck (HP:0002033)2.28680088
58Generalized aminoaciduria (HP:0002909)2.25604718
59Limb dystonia (HP:0002451)2.25031813
60Lethargy (HP:0001254)2.24931592
61Nephrogenic diabetes insipidus (HP:0009806)2.23653669
62Nephronophthisis (HP:0000090)2.20730518
63Hypoglycemic coma (HP:0001325)2.19826277
64Microvesicular hepatic steatosis (HP:0001414)2.17262802
65Hyperinsulinemic hypoglycemia (HP:0000825)2.14174984
66Abnormal hair whorl (HP:0010721)2.06909249
67Degeneration of anterior horn cells (HP:0002398)2.06125661
68Abnormality of the anterior horn cell (HP:0006802)2.06125661
69Abnormal urine phosphate concentration (HP:0012599)2.05255819
70Renal tubular dysfunction (HP:0000124)2.03195090
71Colon cancer (HP:0003003)2.01935882
72Ketoacidosis (HP:0001993)2.00080034
73Abnormal number of erythroid precursors (HP:0012131)1.96826767
74Hyperventilation (HP:0002883)1.96271545
75Reticulocytopenia (HP:0001896)1.95952594
76Type I transferrin isoform profile (HP:0003642)1.94337773
77Epileptic encephalopathy (HP:0200134)1.92560643
78Abnormality of vitamin B metabolism (HP:0004340)1.91788241
79Gliosis (HP:0002171)1.88189621
80Vaginal atresia (HP:0000148)1.88056081
81Sclerocornea (HP:0000647)1.88013651
82Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86360176
83Dicarboxylic aciduria (HP:0003215)1.86360176
84Delusions (HP:0000746)1.83870600
85Genital tract atresia (HP:0001827)1.83858912
86Large for gestational age (HP:0001520)1.82754113
87Absence seizures (HP:0002121)1.82618003
88Methylmalonic aciduria (HP:0012120)1.82563849
89Anxiety (HP:0000739)1.79388089
90Visual hallucinations (HP:0002367)1.78060050
91Methylmalonic acidemia (HP:0002912)1.77589921
92Abnormality of glycine metabolism (HP:0010895)1.77091933
93Abnormality of serine family amino acid metabolism (HP:0010894)1.77091933
94Oral leukoplakia (HP:0002745)1.76836786
95Abnormality of serum amino acid levels (HP:0003112)1.76193347
96Dialeptic seizures (HP:0011146)1.75741768
97Hyperglycinuria (HP:0003108)1.75399761
98Hypomagnesemia (HP:0002917)1.74537766
99Intestinal atresia (HP:0011100)1.73251264
100Aplasia/hypoplasia of the uterus (HP:0008684)1.72955901
101Macrocytic anemia (HP:0001972)1.71764978
102Congenital stationary night blindness (HP:0007642)1.71755652
103Delayed CNS myelination (HP:0002188)1.71493309
104Congenital ichthyosiform erythroderma (HP:0007431)1.71293003
105Ketosis (HP:0001946)1.71069304
106Abnormality of methionine metabolism (HP:0010901)1.70802991
107Abnormality of the renal medulla (HP:0100957)1.70545230
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70503425
109Male pseudohermaphroditism (HP:0000037)1.68683891
110Septo-optic dysplasia (HP:0100842)1.68590905
111Parakeratosis (HP:0001036)1.66782470
112Pendular nystagmus (HP:0012043)1.66369368
113Abnormality of placental membranes (HP:0011409)1.65833856
114Amniotic constriction ring (HP:0009775)1.65833856
115Hypoglycemic seizures (HP:0002173)1.65111571
116Retinal dysplasia (HP:0007973)1.64341299
117Blindness (HP:0000618)1.64033641
118Congenital sensorineural hearing impairment (HP:0008527)1.63071605
119Oligomenorrhea (HP:0000876)1.60400438
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59405560
121Abnormal protein N-linked glycosylation (HP:0012347)1.59405560
122Abnormal protein glycosylation (HP:0012346)1.59405560
123Abnormal glycosylation (HP:0012345)1.59405560
124Cerebral hypomyelination (HP:0006808)1.59072378
125Palpitations (HP:0001962)1.58294165
126Vomiting (HP:0002013)1.57670077
127Aplastic anemia (HP:0001915)1.57420143
128Septate vagina (HP:0001153)1.55266833
129Polyphagia (HP:0002591)1.54930527
130Cerebral hemorrhage (HP:0001342)1.54099604
131Abnormal autonomic nervous system physiology (HP:0012332)1.53519711
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.53229989
133Vacuolated lymphocytes (HP:0001922)1.52278789
134Conjunctival hamartoma (HP:0100780)1.51788672
135Hypoplasia of the uterus (HP:0000013)1.50576969
136Abnormality of alanine metabolism (HP:0010916)1.48869773
137Hyperalaninemia (HP:0003348)1.48869773
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.48869773
139Hypokinesia (HP:0002375)1.46441753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.35145615
2VRK24.06655196
3NME13.72537958
4CASK3.63607926
5STK163.22532918
6MAP4K23.10338648
7ZAK2.53369024
8MAP2K72.42832000
9ARAF2.37847568
10MYLK2.25825351
11FRK2.18319277
12NUAK12.17936880
13NME22.15499824
14BUB12.05199999
15BRAF2.00867527
16GRK51.85778394
17OXSR11.81489779
18CDK191.73132747
19NTRK31.72443497
20GRK71.68410314
21STK391.67492989
22NEK11.66745346
23MST41.63023923
24WNK41.61499353
25MAP3K41.60574280
26TRIM281.58334443
27PLK31.55135112
28VRK11.55013529
29BMPR1B1.52459745
30BMPR21.49103170
31GRK11.48505817
32BCR1.48468044
33PBK1.46537753
34EIF2AK31.41747845
35ADRBK21.39446760
36TNIK1.33944029
37PNCK1.27925045
38MUSK1.27182631
39PLK21.22968265
40EIF2AK11.20247907
41CDC71.19997062
42CAMK2B1.16350004
43WNK31.15521888
44MAPK131.14548198
45CDK81.10890434
46BCKDK1.10843323
47EPHA41.10557506
48TESK11.07140737
49DAPK11.06719882
50PLK41.06502618
51MAPKAPK51.05940730
52TSSK61.05831710
53AKT31.05136764
54TLK11.03890999
55LIMK11.02916745
56PDK21.01772591
57MARK11.01390315
58MINK11.00851066
59CSNK1A1L0.99434514
60RIPK40.97626758
61UHMK10.96498730
62CAMK2A0.96108375
63WEE10.95218594
64CAMK2D0.94027878
65ADRBK10.92978571
66PLK10.92882033
67TAF10.89422064
68CCNB10.89340391
69BRSK20.88694194
70CSNK1G30.86873232
71PAK30.86031665
72MAP2K40.85292817
73CAMK2G0.84796210
74DYRK20.84463170
75OBSCN0.82685706
76PRKCE0.81854918
77SRPK10.80444352
78MKNK20.78307535
79TTK0.77982220
80ACVR1B0.75171139
81BRSK10.74807337
82ERBB30.73384354
83PRKCG0.71875043
84RPS6KA50.69980843
85ABL20.69920998
86PIM20.68875512
87MAPKAPK30.68727432
88FGFR20.67524529
89DAPK20.64251804
90KDR0.63121975
91CDK50.60551241
92PRKCI0.59297588
93CDK140.58290693
94PRKACA0.58280830
95INSRR0.57864141
96MAP2K20.57372388
97SIK30.56533908
98LMTK20.55182564
99MAPK150.54046965
100MKNK10.53891977
101AURKB0.53418857
102DAPK30.52087285
103AURKA0.51786715
104CSNK1A10.49703835
105CDK180.49565968
106NTRK10.48399705
107STK38L0.47727983
108TIE10.46633681
109CSNK1G20.45917552
110SGK2230.44502932
111SGK4940.44502932
112PTK2B0.43387125
113CAMKK20.43249240
114CDK150.42478977
115CSNK1G10.41821741
116STK40.41739876
117CSNK2A10.40717056
118CSNK1E0.40367509
119CDK11A0.39692121
120NEK60.39640592
121PDK30.39309533
122PDK40.39309533
123PASK0.39207274
124PKN10.39132126
125FGR0.38493213
126ILK0.38040232
127MST1R0.37705431
128DYRK1A0.37369767
129TESK20.37304857
130CSNK2A20.37207155
131PIK3CG0.37100426
132YES10.37025222
133MAP3K90.36788107
134MAP3K110.35785762
135PINK10.34823035
136PHKG20.34493790
137PHKG10.34493790

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.33435771
2Parkinsons disease_Homo sapiens_hsa050125.24924056
3Alzheimers disease_Homo sapiens_hsa050104.04676703
4Huntingtons disease_Homo sapiens_hsa050163.67518262
5Protein export_Homo sapiens_hsa030603.44208914
6Proteasome_Homo sapiens_hsa030503.37570597
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.18491818
8Ribosome_Homo sapiens_hsa030103.16516389
9Collecting duct acid secretion_Homo sapiens_hsa049662.98983317
10Cardiac muscle contraction_Homo sapiens_hsa042602.31312729
11Vibrio cholerae infection_Homo sapiens_hsa051102.21505954
12RNA polymerase_Homo sapiens_hsa030201.96836211
13Synaptic vesicle cycle_Homo sapiens_hsa047211.92793980
14Sulfur metabolism_Homo sapiens_hsa009201.81908511
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74075602
16Nicotine addiction_Homo sapiens_hsa050331.61372905
17Fatty acid elongation_Homo sapiens_hsa000621.53164886
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51140030
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.44732432
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42728152
21DNA replication_Homo sapiens_hsa030301.38100434
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35747372
23Base excision repair_Homo sapiens_hsa034101.16310551
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12505577
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11103526
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11036073
27Vitamin B6 metabolism_Homo sapiens_hsa007501.10796011
28Rheumatoid arthritis_Homo sapiens_hsa053231.07900508
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05949088
30Pyruvate metabolism_Homo sapiens_hsa006201.04020819
31Sulfur relay system_Homo sapiens_hsa041221.03710475
32One carbon pool by folate_Homo sapiens_hsa006701.02640163
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.02446968
34Pyrimidine metabolism_Homo sapiens_hsa002401.02143363
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00904308
36Taste transduction_Homo sapiens_hsa047421.00871360
37Fanconi anemia pathway_Homo sapiens_hsa034601.00012375
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98125877
39Tryptophan metabolism_Homo sapiens_hsa003800.97605922
40Serotonergic synapse_Homo sapiens_hsa047260.97312826
41Chemical carcinogenesis_Homo sapiens_hsa052040.97278330
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96960304
43GABAergic synapse_Homo sapiens_hsa047270.96659676
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95401601
45Non-homologous end-joining_Homo sapiens_hsa034500.95047092
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90779377
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89311190
48Metabolic pathways_Homo sapiens_hsa011000.86062999
49Nitrogen metabolism_Homo sapiens_hsa009100.84633296
50Amphetamine addiction_Homo sapiens_hsa050310.82198157
51Selenocompound metabolism_Homo sapiens_hsa004500.80510309
52Morphine addiction_Homo sapiens_hsa050320.79734924
53Retinol metabolism_Homo sapiens_hsa008300.79509400
54Purine metabolism_Homo sapiens_hsa002300.77431466
55Caffeine metabolism_Homo sapiens_hsa002320.76385899
56beta-Alanine metabolism_Homo sapiens_hsa004100.74999613
57Phototransduction_Homo sapiens_hsa047440.74509122
58Fatty acid degradation_Homo sapiens_hsa000710.74209300
59Insulin secretion_Homo sapiens_hsa049110.72501538
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70191680
61RNA transport_Homo sapiens_hsa030130.69741896
62Folate biosynthesis_Homo sapiens_hsa007900.69434530
63Regulation of autophagy_Homo sapiens_hsa041400.67239371
64Butanoate metabolism_Homo sapiens_hsa006500.65819951
65Phenylalanine metabolism_Homo sapiens_hsa003600.65817049
66Phagosome_Homo sapiens_hsa041450.65337343
67Fatty acid metabolism_Homo sapiens_hsa012120.64575178
68Dopaminergic synapse_Homo sapiens_hsa047280.63843575
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63203764
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.61733598
71Tyrosine metabolism_Homo sapiens_hsa003500.60535045
72Circadian entrainment_Homo sapiens_hsa047130.60418381
73Cocaine addiction_Homo sapiens_hsa050300.57811764
74Mineral absorption_Homo sapiens_hsa049780.57523237
75Fat digestion and absorption_Homo sapiens_hsa049750.56637627
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.56283562
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55715116
78Sphingolipid metabolism_Homo sapiens_hsa006000.53799256
79Propanoate metabolism_Homo sapiens_hsa006400.53209829
80Type I diabetes mellitus_Homo sapiens_hsa049400.52761091
81Other glycan degradation_Homo sapiens_hsa005110.52266917
82Steroid biosynthesis_Homo sapiens_hsa001000.52016187
83Olfactory transduction_Homo sapiens_hsa047400.51218514
84Arachidonic acid metabolism_Homo sapiens_hsa005900.50717242
85Histidine metabolism_Homo sapiens_hsa003400.50404970
86Ether lipid metabolism_Homo sapiens_hsa005650.50325432
87Vitamin digestion and absorption_Homo sapiens_hsa049770.49356252
88Long-term potentiation_Homo sapiens_hsa047200.49038830
89Glutamatergic synapse_Homo sapiens_hsa047240.48275509
90Glutathione metabolism_Homo sapiens_hsa004800.46882018
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45852563
92Linoleic acid metabolism_Homo sapiens_hsa005910.44631894
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44387014
94Pancreatic secretion_Homo sapiens_hsa049720.43470847
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43071499
96Basal transcription factors_Homo sapiens_hsa030220.41701511
97Long-term depression_Homo sapiens_hsa047300.40438010
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39606873
99Fructose and mannose metabolism_Homo sapiens_hsa000510.39257301
100N-Glycan biosynthesis_Homo sapiens_hsa005100.38980972
101Calcium signaling pathway_Homo sapiens_hsa040200.38934302
102Nucleotide excision repair_Homo sapiens_hsa034200.37608943
103Carbon metabolism_Homo sapiens_hsa012000.36912398
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36904201
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36250241
106Peroxisome_Homo sapiens_hsa041460.36164711
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35687811
108Cholinergic synapse_Homo sapiens_hsa047250.34412250
109Arginine biosynthesis_Homo sapiens_hsa002200.34117371
110Arginine and proline metabolism_Homo sapiens_hsa003300.33678315
111Spliceosome_Homo sapiens_hsa030400.32478868
112Biosynthesis of amino acids_Homo sapiens_hsa012300.32317867
113RNA degradation_Homo sapiens_hsa030180.30961180
114Renin secretion_Homo sapiens_hsa049240.30933479
115Homologous recombination_Homo sapiens_hsa034400.30617482
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29917576
117Salivary secretion_Homo sapiens_hsa049700.27926782
118Oocyte meiosis_Homo sapiens_hsa041140.27271022
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24692125
120Alcoholism_Homo sapiens_hsa050340.24231054
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22676926
122Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22592988
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21990783
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20944424
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20602111
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20090211
127Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.19734509
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.19120582
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.18576851
130Mismatch repair_Homo sapiens_hsa034300.16549061
131Galactose metabolism_Homo sapiens_hsa000520.16322052
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15351532
133Gastric acid secretion_Homo sapiens_hsa049710.14535934

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