COASY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.39996032
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.39996032
3L-phenylalanine metabolic process (GO:0006558)7.18678556
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18678556
5aromatic amino acid family catabolic process (GO:0009074)6.61900725
6glyoxylate metabolic process (GO:0046487)6.13634486
7cysteine metabolic process (GO:0006534)5.98006169
8indole-containing compound catabolic process (GO:0042436)5.91255904
9indolalkylamine catabolic process (GO:0046218)5.91255904
10tryptophan catabolic process (GO:0006569)5.91255904
11kynurenine metabolic process (GO:0070189)5.66804693
12tryptophan metabolic process (GO:0006568)5.59138408
13bile acid biosynthetic process (GO:0006699)5.56631158
14lysine catabolic process (GO:0006554)5.49727291
15lysine metabolic process (GO:0006553)5.49727291
16sulfur amino acid catabolic process (GO:0000098)5.48371752
17alpha-linolenic acid metabolic process (GO:0036109)5.46093375
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.44070945
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.21969446
20serine family amino acid catabolic process (GO:0009071)5.17244500
21proline biosynthetic process (GO:0006561)5.17088902
22COPI coating of Golgi vesicle (GO:0048205)5.10460659
23Golgi transport vesicle coating (GO:0048200)5.10460659
24urea cycle (GO:0000050)4.93515384
25urea metabolic process (GO:0019627)4.93515384
26aromatic amino acid family metabolic process (GO:0009072)4.87106974
27homocysteine metabolic process (GO:0050667)4.83294196
28amino-acid betaine metabolic process (GO:0006577)4.79104948
29bile acid metabolic process (GO:0008206)4.71949538
30negative regulation of fibrinolysis (GO:0051918)4.69320391
31alpha-amino acid catabolic process (GO:1901606)4.64908374
32cellular ketone body metabolic process (GO:0046950)4.63497817
33high-density lipoprotein particle remodeling (GO:0034375)4.63030447
34nitrogen cycle metabolic process (GO:0071941)4.59925792
35serine family amino acid metabolic process (GO:0009069)4.59601843
36peptidyl-glutamic acid carboxylation (GO:0017187)4.58305389
37protein carboxylation (GO:0018214)4.58305389
38complement activation, alternative pathway (GO:0006957)4.54429585
39tyrosine metabolic process (GO:0006570)4.50414008
40drug transmembrane transport (GO:0006855)4.47218419
41regulation of fibrinolysis (GO:0051917)4.43558784
42regulation of protein activation cascade (GO:2000257)4.43545324
43serine family amino acid biosynthetic process (GO:0009070)4.42607543
44urate metabolic process (GO:0046415)4.41500943
45glycine metabolic process (GO:0006544)4.41358596
46cellular amino acid catabolic process (GO:0009063)4.40710248
47regulation of triglyceride catabolic process (GO:0010896)4.40044771
48short-chain fatty acid metabolic process (GO:0046459)4.38565422
49cellular modified amino acid catabolic process (GO:0042219)4.28168342
50coenzyme catabolic process (GO:0009109)4.25463874
51regulation of translational fidelity (GO:0006450)4.21947616
52acetyl-CoA metabolic process (GO:0006084)4.21684056
53ethanol oxidation (GO:0006069)4.21395939
54drug catabolic process (GO:0042737)4.19777918
55glutamate metabolic process (GO:0006536)4.18706710
56indolalkylamine metabolic process (GO:0006586)4.18147501
57regulation of complement activation (GO:0030449)4.15656979
58negative regulation of sterol transport (GO:0032372)4.14097241
59negative regulation of cholesterol transport (GO:0032375)4.14097241
60acylglycerol homeostasis (GO:0055090)4.13266086
61triglyceride homeostasis (GO:0070328)4.13266086
62cellular biogenic amine catabolic process (GO:0042402)4.08646283
63amine catabolic process (GO:0009310)4.08646283
64aspartate family amino acid catabolic process (GO:0009068)4.06912366
65fatty acid beta-oxidation (GO:0006635)4.04477660
66protein maturation by protein folding (GO:0022417)4.03363008
67proline metabolic process (GO:0006560)4.03060194
68regulation of cholesterol esterification (GO:0010872)4.02679137
69benzene-containing compound metabolic process (GO:0042537)4.02148197
70reverse cholesterol transport (GO:0043691)4.01994801
71ketone body metabolic process (GO:1902224)4.01962714
72protein-lipid complex remodeling (GO:0034368)4.00708790
73macromolecular complex remodeling (GO:0034367)4.00708790
74plasma lipoprotein particle remodeling (GO:0034369)4.00708790
75aldehyde catabolic process (GO:0046185)4.00340332
76organic acid catabolic process (GO:0016054)3.99088750
77carboxylic acid catabolic process (GO:0046395)3.99088750
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.95717663
79fatty acid oxidation (GO:0019395)3.95007159
80bile acid and bile salt transport (GO:0015721)3.92424940
81valine metabolic process (GO:0006573)3.91729926
82plasma lipoprotein particle clearance (GO:0034381)3.91170616
83protein retention in ER lumen (GO:0006621)3.91064042
84cellular glucuronidation (GO:0052695)3.89003728
852-oxoglutarate metabolic process (GO:0006103)3.87125368
86lipid oxidation (GO:0034440)3.86845846
87pentose-phosphate shunt (GO:0006098)3.84662889
88imidazole-containing compound metabolic process (GO:0052803)3.83397818
89fatty acid catabolic process (GO:0009062)3.82863899
90monocarboxylic acid catabolic process (GO:0072329)3.81924795
91drug transport (GO:0015893)3.79454516
92exogenous drug catabolic process (GO:0042738)3.79160430
93phospholipid efflux (GO:0033700)3.71709450
94negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.71026576
95carnitine metabolic process (GO:0009437)3.70637556
96branched-chain amino acid catabolic process (GO:0009083)3.69339715
97glucose 6-phosphate metabolic process (GO:0051156)3.63639924
98arginine metabolic process (GO:0006525)3.62878051
99branched-chain amino acid metabolic process (GO:0009081)3.61332098
100GDP-mannose metabolic process (GO:0019673)3.59562178
101regulation of cholesterol homeostasis (GO:2000188)3.59467869
102NADPH regeneration (GO:0006740)3.56379539
103drug metabolic process (GO:0017144)3.54717536
104pinocytosis (GO:0006907)3.53685469
105glucose catabolic process (GO:0006007)3.53048344
106dicarboxylic acid biosynthetic process (GO:0043650)3.52404887
107glucuronate metabolic process (GO:0019585)3.51343868
108uronic acid metabolic process (GO:0006063)3.51343868
109cofactor catabolic process (GO:0051187)3.50889242
110heme transport (GO:0015886)3.49569369
111retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46999894
112flavonoid metabolic process (GO:0009812)3.45713087
113response to nitrosative stress (GO:0051409)3.45542585
114cholesterol homeostasis (GO:0042632)3.43473655
115cholesterol efflux (GO:0033344)3.42803824
116positive regulation of lipoprotein lipase activity (GO:0051006)3.41820574
117regulation of mammary gland epithelial cell proliferation (GO:0033599)3.35748102
118oxaloacetate metabolic process (GO:0006107)3.35599508
119plasma lipoprotein particle assembly (GO:0034377)3.25493811
120NADH metabolic process (GO:0006734)3.22072562
121very-low-density lipoprotein particle assembly (GO:0034379)3.12371545
122regulation of cholesterol biosynthetic process (GO:0045540)3.09045669
123ribosomal small subunit biogenesis (GO:0042274)3.08173128
124regulation of superoxide anion generation (GO:0032928)3.04623471
125protein-lipid complex assembly (GO:0065005)3.02030460
126glutamine family amino acid biosynthetic process (GO:0009084)2.97207117
127monosaccharide biosynthetic process (GO:0046364)2.96704226
128formation of translation preinitiation complex (GO:0001731)2.94451319
129pentose metabolic process (GO:0019321)2.90484892
130activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.85062348
131spliceosomal tri-snRNP complex assembly (GO:0000244)2.84159872
132tricarboxylic acid metabolic process (GO:0072350)2.82626251
133positive regulation of nuclease activity (GO:0032075)2.80424789
134low-density lipoprotein particle clearance (GO:0034383)2.80217421
135deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79219816
136folic acid metabolic process (GO:0046655)2.78409475
137DNA unwinding involved in DNA replication (GO:0006268)2.74540911
138gluconeogenesis (GO:0006094)2.73815728
139nucleobase-containing small molecule interconversion (GO:0015949)2.70726108
140regulation of translational termination (GO:0006449)2.69401482
141regulation of early endosome to late endosome transport (GO:2000641)2.68689827
142hexose biosynthetic process (GO:0019319)2.68187070
143L-serine metabolic process (GO:0006563)2.63093852
1444-hydroxyproline metabolic process (GO:0019471)2.62375465
145peptidyl-arginine omega-N-methylation (GO:0035247)2.60119190
146regulation of nuclease activity (GO:0032069)2.56921526
147UV protection (GO:0009650)2.51118423
148negative regulation of cell size (GO:0045792)2.48636666
149regulation of cholesterol metabolic process (GO:0090181)2.47779635
150glycolytic process (GO:0006096)2.46039343
151endoplasmic reticulum unfolded protein response (GO:0030968)2.45195128
152basement membrane organization (GO:0071711)2.44648278
153mitotic chromosome condensation (GO:0007076)2.44483820
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.44347301
155apoptotic process involved in morphogenesis (GO:0060561)2.44019854
156nuclear envelope reassembly (GO:0031468)2.43994008
157mitotic nuclear envelope reassembly (GO:0007084)2.43994008
158positive regulation of triglyceride lipase activity (GO:0061365)2.43021847
159glycosphingolipid catabolic process (GO:0046479)2.42755437
160negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.40486092
161negative regulation of myeloid cell apoptotic process (GO:0033033)2.40299681
162negative regulation of erythrocyte differentiation (GO:0045647)2.35593318
163ER-nucleus signaling pathway (GO:0006984)2.34616192
164positive regulation of fatty acid biosynthetic process (GO:0045723)2.33332183
165glycolipid catabolic process (GO:0019377)2.31715269
166pyrimidine nucleoside salvage (GO:0043097)2.31482236
167pyrimidine-containing compound salvage (GO:0008655)2.31482236
168mitochondrial fusion (GO:0008053)2.30808818
169folic acid-containing compound biosynthetic process (GO:0009396)2.30076071
170positive regulation of Cdc42 GTPase activity (GO:0043089)2.28508876
171activation of Rac GTPase activity (GO:0032863)2.28033710
172protoporphyrinogen IX metabolic process (GO:0046501)2.27805786
1733-UTR-mediated mRNA stabilization (GO:0070935)2.26768033
174cellular response to unfolded protein (GO:0034620)2.24799492
175intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.24416494
176negative regulation of fatty acid biosynthetic process (GO:0045717)2.23804931
177negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.23505751
178ribonucleoprotein complex biogenesis (GO:0022613)2.23193253
179heterochromatin organization (GO:0070828)2.22129693
180cellular modified amino acid biosynthetic process (GO:0042398)2.20511665
181intestinal cholesterol absorption (GO:0030299)2.19986616
182desmosome organization (GO:0002934)2.19854424
183folic acid-containing compound metabolic process (GO:0006760)2.19801987
184nucleotide salvage (GO:0043173)2.19508740
185establishment of integrated proviral latency (GO:0075713)2.19288806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.97351884
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.96506976
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.13962847
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.09255306
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.00725141
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.86998703
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.78290484
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01568186
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.50011807
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.70915280
11E2F7_22180533_ChIP-Seq_HELA_Human2.66470597
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47509455
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.35525270
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.29848368
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.24063471
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20814132
17MYC_22102868_ChIP-Seq_BL_Human2.19464060
18* VDR_21846776_ChIP-Seq_THP-1_Human2.10316601
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03418789
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02964979
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2537408
22CLOCK_20551151_ChIP-Seq_293T_Human1.93219748
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.85455747
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78674141
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74764519
26XRN2_22483619_ChIP-Seq_HELA_Human1.72686529
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72309028
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69725595
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64677535
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62291264
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48905968
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47990756
33* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47075927
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46849761
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41382133
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38499987
37KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37826304
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37813521
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.37775579
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35503508
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.35073345
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34859227
43GATA1_22025678_ChIP-Seq_K562_Human1.34644191
44DCP1A_22483619_ChIP-Seq_HELA_Human1.34504842
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33715408
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31719027
47* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30361353
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28650525
49* GABP_19822575_ChIP-Seq_HepG2_Human1.28562726
50* ETS1_20019798_ChIP-Seq_JURKAT_Human1.28171274
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26667303
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.26354702
53ATF3_27146783_Chip-Seq_COLON_Human1.25882785
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25569591
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.22029162
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21984870
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21108764
58NCOR1_26117541_ChIP-Seq_K562_Human1.20122801
59* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19699590
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.19368303
61* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19137500
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18722887
63TCF7_22412390_ChIP-Seq_EML_Mouse1.18711383
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18441758
65ZNF263_19887448_ChIP-Seq_K562_Human1.18099322
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17862008
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17755831
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17607312
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.17254827
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17232922
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16659983
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16232926
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13327818
74* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11598538
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10336737
76MAF_26560356_Chip-Seq_TH1_Human1.10249205
77HTT_18923047_ChIP-ChIP_STHdh_Human1.08860388
78KDM2B_26808549_Chip-Seq_DND41_Human1.08632314
79* ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08274554
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08076094
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07654733
82MAF_26560356_Chip-Seq_TH2_Human1.06440911
83TFEB_21752829_ChIP-Seq_HELA_Human1.05195871
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04711642
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04121115
86KDM5A_27292631_Chip-Seq_BREAST_Human1.03721445
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03242219
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03091181
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01724767
90SMC4_20622854_ChIP-Seq_HELA_Human1.01599164
91UTX_26944678_Chip-Seq_JUKART_Human1.01134797
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00209999
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99652396
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99450016
95TTF2_22483619_ChIP-Seq_HELA_Human0.99417834
96GATA4_25053715_ChIP-Seq_YYC3_Human0.96879358
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96447406
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95779170
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93911039
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92974452
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91162236
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90441697
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89971641
104* LXR_22292898_ChIP-Seq_THP-1_Human0.89732935
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88807033
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85215651
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79832328
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.79669272
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.78384892
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74087024
111RARB_24833708_ChIP-Seq_LIVER_Mouse0.73432079
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.72800504
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70696993
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70311712
115* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70201250
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67913011
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67533900
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.67331498
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65321413
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.65153628
121ESR2_21235772_ChIP-Seq_MCF-7_Human0.64444601
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.62646906
123AR_20517297_ChIP-Seq_VCAP_Human0.61559443
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.60632507
125GATA6_25053715_ChIP-Seq_YYC3_Human0.59804778
126CEBPB_22108803_ChIP-Seq_LS180_Human0.59363225
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.59232072
128RACK7_27058665_Chip-Seq_MCF-7_Human0.58880024
129BCOR_27268052_Chip-Seq_Bcells_Human0.56824353
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56780540
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.55708830
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.54082711
133* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53912559
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53714798
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.53290156
136MYC_19915707_ChIP-ChIP_AK7_Human0.52991213
137* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52898864
138ERG_20517297_ChIP-Seq_VCAP_Human0.52812635
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.52633929
140TAF2_19829295_ChIP-Seq_ESCs_Human0.52610470
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.52220961
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.51883373
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.50944870
144ESET_19884257_ChIP-Seq_ESCs_Mouse0.50675015
145AR_21909140_ChIP-Seq_LNCAP_Human0.50096256
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.49856478
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49411578
148EGR1_19032775_ChIP-ChIP_M12_Human0.48016561
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47995107
150P53_21459846_ChIP-Seq_SAOS-2_Human0.47707595
151* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.47598611
152CDX2_20551321_ChIP-Seq_CACO-2_Human0.47272982
153FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46387879
154BCL6_27268052_Chip-Seq_Bcells_Human0.46127319
155* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.45573304
156FOXA1_25552417_ChIP-Seq_VCAP_Human0.45546308
157P300_27268052_Chip-Seq_Bcells_Human0.45061226
158RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.44132709
159SOX2_22085726_ChIP-Seq_NPCs_Mouse0.43737542
160OCT4_18692474_ChIP-Seq_MEFs_Mouse0.43708800
161ELF1_17652178_ChIP-ChIP_JURKAT_Human0.43198174
162EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.43114445
163CTCF_21964334_Chip-Seq_Bcells_Human0.42892845
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.42299663
165P68_20966046_ChIP-Seq_HELA_Human0.42242427
166NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.42104667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.90394350
2MP0005360_urolithiasis7.59631148
3MP0005365_abnormal_bile_salt5.86964588
4MP0005085_abnormal_gallbladder_physiolo5.86679091
5MP0008875_abnormal_xenobiotic_pharmacok4.86747260
6MP0003806_abnormal_nucleotide_metabolis4.24038521
7MP0003252_abnormal_bile_duct3.63796058
8MP0010329_abnormal_lipoprotein_level3.35032553
9MP0005332_abnormal_amino_acid3.30640626
10MP0003195_calcinosis3.10568825
11MP0009840_abnormal_foam_cell3.04048894
12MP0005083_abnormal_biliary_tract2.90519112
13MP0008260_abnormal_autophagy2.74258770
14MP0001666_abnormal_nutrient_absorption2.69226408
15MP0004019_abnormal_vitamin_homeostasis2.60988178
16MP0003172_abnormal_lysosome_physiology2.44173886
17MP0003191_abnormal_cellular_cholesterol2.28157194
18MP0002118_abnormal_lipid_homeostasis2.15048646
19MP0002138_abnormal_hepatobiliary_system2.11905912
20MP0000609_abnormal_liver_physiology2.10163888
21MP0001849_ear_inflammation2.06765764
22MP0003111_abnormal_nucleus_morphology2.05992179
23MP0000678_abnormal_parathyroid_gland1.97915920
24MP0003693_abnormal_embryo_hatching1.97242192
25MP0005319_abnormal_enzyme/_coenzyme1.91155893
26MP0009643_abnormal_urine_homeostasis1.85576342
27MP0009333_abnormal_splenocyte_physiolog1.79480845
28MP0005076_abnormal_cell_differentiation1.77674338
29MP0005584_abnormal_enzyme/coenzyme_acti1.76664079
30MP0003436_decreased_susceptibility_to1.75697376
31MP0000858_altered_metastatic_potential1.73069719
32MP0001764_abnormal_homeostasis1.72802877
33MP0003868_abnormal_feces_composition1.72327595
34MP0003566_abnormal_cell_adhesion1.70319862
35MP0004957_abnormal_blastocyst_morpholog1.67143350
36MP0003186_abnormal_redox_activity1.66837380
37MP0002877_abnormal_melanocyte_morpholog1.62429882
38MP0004858_abnormal_nervous_system1.61754396
39MP0001730_embryonic_growth_arrest1.56574812
40MP0005501_abnormal_skin_physiology1.56394849
41MP0002132_abnormal_respiratory_system1.55793419
42MP0003453_abnormal_keratinocyte_physiol1.51266895
43MP0004233_abnormal_muscle_weight1.48392026
44MP0005451_abnormal_body_composition1.45688218
45MP0005636_abnormal_mineral_homeostasis1.37930541
46MP0002089_abnormal_postnatal_growth/wei1.34310421
47MP0005670_abnormal_white_adipose1.33955948
48MP0009278_abnormal_bone_marrow1.29739361
49MP0006036_abnormal_mitochondrial_physio1.27679539
50MP0003077_abnormal_cell_cycle1.26858796
51MP0003123_paternal_imprinting1.26746899
52MP0000490_abnormal_crypts_of1.25147808
53MP0003315_abnormal_perineum_morphology1.23197334
54MP0004043_abnormal_pH_regulation1.21291000
55MP0000598_abnormal_liver_morphology1.20800808
56MP0003656_abnormal_erythrocyte_physiolo1.20686511
57MP0001853_heart_inflammation1.20652228
58MP0003011_delayed_dark_adaptation1.17573124
59MP0008932_abnormal_embryonic_tissue1.15109860
60MP0005257_abnormal_intraocular_pressure1.14466508
61MP0009697_abnormal_copulation1.13585032
62MP0003303_peritoneal_inflammation1.11331161
63MP0001756_abnormal_urination1.10113999
64MP0002080_prenatal_lethality1.07053407
65MP0000350_abnormal_cell_proliferation1.05488960
66MP0000003_abnormal_adipose_tissue1.04637292
67MP0004947_skin_inflammation1.02295848
68MP0003705_abnormal_hypodermis_morpholog1.01084251
69MP0000604_amyloidosis1.00801771
70MP0005220_abnormal_exocrine_pancreas1.00511455
71MP0000313_abnormal_cell_death1.00487593
72MP0005084_abnormal_gallbladder_morpholo0.98270814
73MP0002396_abnormal_hematopoietic_system0.97355282
74MP0005647_abnormal_sex_gland0.96583096
75MP0010094_abnormal_chromosome_stability0.95129092
76MP0000358_abnormal_cell_content/0.94852154
77MP0000681_abnormal_thyroid_gland0.93939928
78MP0009642_abnormal_blood_homeostasis0.93402609
79MP0005409_darkened_coat_color0.93159382
80MP0002876_abnormal_thyroid_physiology0.92729480
81MP0005023_abnormal_wound_healing0.92624585
82MP0001661_extended_life_span0.91234555
83MP0005058_abnormal_lysosome_morphology0.90223481
84MP0002078_abnormal_glucose_homeostasis0.89199712
85MP0008469_abnormal_protein_level0.88702399
86MP0009763_increased_sensitivity_to0.88175732
87MP0001915_intracranial_hemorrhage0.87621728
88MP0002971_abnormal_brown_adipose0.87590318
89MP0002136_abnormal_kidney_physiology0.86900109
90MP0009764_decreased_sensitivity_to0.86533476
91MP0000685_abnormal_immune_system0.86427421
92MP0001216_abnormal_epidermal_layer0.85559682
93MP0005535_abnormal_body_temperature0.84057689
94MP0005666_abnormal_adipose_tissue0.82351125
95MP0005025_abnormal_response_to0.82267951
96MP0005621_abnormal_cell_physiology0.82223292
97MP0004130_abnormal_muscle_cell0.82152951
98MP0002019_abnormal_tumor_incidence0.81941472
99MP0005408_hypopigmentation0.81088122
100MP0008007_abnormal_cellular_replicative0.80592829
101MP0005384_cellular_phenotype0.79617590
102MP0005330_cardiomyopathy0.79092517
103MP0001873_stomach_inflammation0.78504535
104MP0002086_abnormal_extraembryonic_tissu0.78494052
105MP0005380_embryogenesis_phenotype0.76991635
106MP0001672_abnormal_embryogenesis/_devel0.76991635
107MP0009931_abnormal_skin_appearance0.76374303
108MP0003984_embryonic_growth_retardation0.76128321
109MP0005334_abnormal_fat_pad0.76127399
110MP0005376_homeostasis/metabolism_phenot0.75721484
111MP0003329_amyloid_beta_deposits0.75417825
112MP0001765_abnormal_ion_homeostasis0.74232867
113MP0009765_abnormal_xenobiotic_induced0.73905807
114MP0010155_abnormal_intestine_physiology0.72908178
115MP0001697_abnormal_embryo_size0.72865110
116MP0006035_abnormal_mitochondrial_morpho0.72382267
117MP0005397_hematopoietic_system_phenotyp0.70358080
118MP0005266_abnormal_metabolism0.66286822
119MP0003690_abnormal_glial_cell0.62110913
120MP0002254_reproductive_system_inflammat0.55180319
121MP0005448_abnormal_energy_balance0.53585984
122MP0003638_abnormal_response/metabolism_0.52763232
123MP0010368_abnormal_lymphatic_system0.52088641
124MP0003953_abnormal_hormone_level0.52050530
125MP0002928_abnormal_bile_duct0.51955467
126MP0005395_other_phenotype0.49750745
127MP0000639_abnormal_adrenal_gland0.49214777
128MP0009672_abnormal_birth_weight0.49080934
129MP0002970_abnormal_white_adipose0.47327262
130MP0003959_abnormal_lean_body0.47323116
131MP0000230_abnormal_systemic_arterial0.45889611
132MP0008873_increased_physiological_sensi0.45433794
133MP0004782_abnormal_surfactant_physiolog0.41953427
134MP0002168_other_aberrant_phenotype0.40941556
135MP0009115_abnormal_fat_cell0.40886359
136MP0002135_abnormal_kidney_morphology0.40315337
137MP0004264_abnormal_extraembryonic_tissu0.40081991
138MP0002796_impaired_skin_barrier0.40035761
139MP0009053_abnormal_anal_canal0.39755193
140MP0003724_increased_susceptibility_to0.38981881
141MP0001944_abnormal_pancreas_morphology0.38346859
142MP0003718_maternal_effect0.38140388
143MP0004147_increased_porphyrin_level0.37354765
144MP0002837_dystrophic_cardiac_calcinosis0.37048154
145MP0005375_adipose_tissue_phenotype0.36933760
146MP0000538_abnormal_urinary_bladder0.35724593
147MP0005464_abnormal_platelet_physiology0.35231693
148MP0008872_abnormal_physiological_respon0.33821757
149MP0010234_abnormal_vibrissa_follicle0.32585038
150MP0008874_decreased_physiological_sensi0.32452926
151MP0001845_abnormal_inflammatory_respons0.30056449
152MP0004185_abnormal_adipocyte_glucose0.28774668
153MP0003300_gastrointestinal_ulcer0.28378290
154MP0001881_abnormal_mammary_gland0.27724918
155MP0005452_abnormal_adipose_tissue0.27418254
156MP0003075_altered_response_to0.25283728
157MP0009384_cardiac_valve_regurgitation0.24769621
158MP0005166_decreased_susceptibility_to0.23940260

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.96977759
2Intrahepatic cholestasis (HP:0001406)6.29873042
3Deep venous thrombosis (HP:0002625)6.03357884
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.77213677
5Xanthomatosis (HP:0000991)5.63749476
6Hypobetalipoproteinemia (HP:0003563)5.37966868
7Prolonged partial thromboplastin time (HP:0003645)5.13378130
8Ketosis (HP:0001946)4.77517450
9Hyperammonemia (HP:0001987)4.76042373
10Hyperglycinuria (HP:0003108)4.75763383
11Hyperlipoproteinemia (HP:0010980)4.75524301
12Hyperglycinemia (HP:0002154)4.61401758
13Abnormality of serine family amino acid metabolism (HP:0010894)4.57293637
14Abnormality of glycine metabolism (HP:0010895)4.57293637
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.52378357
16Complement deficiency (HP:0004431)4.30641939
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14108704
18Hypoglycemic coma (HP:0001325)4.10348938
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.07656514
20Abnormality of fatty-acid metabolism (HP:0004359)4.01454098
21Hypolipoproteinemia (HP:0010981)3.96591099
22Ketoacidosis (HP:0001993)3.88168666
23Epidermoid cyst (HP:0200040)3.77747754
24Joint hemorrhage (HP:0005261)3.76770303
25Fat malabsorption (HP:0002630)3.69308489
26Gout (HP:0001997)3.68435003
27Abnormality of methionine metabolism (HP:0010901)3.67876476
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.65393984
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.63421845
30Abnormality of the common coagulation pathway (HP:0010990)3.62469616
31Delayed CNS myelination (HP:0002188)3.49091364
32Hypoalphalipoproteinemia (HP:0003233)3.39560513
33Abnormality of purine metabolism (HP:0004352)3.39465332
34Abnormality of nucleobase metabolism (HP:0010932)3.38536589
35Dicarboxylic aciduria (HP:0003215)3.38334175
36Abnormality of dicarboxylic acid metabolism (HP:0010995)3.38334175
37Vertebral compression fractures (HP:0002953)3.37906863
38Abnormality of pyrimidine metabolism (HP:0004353)3.36679102
39Conjugated hyperbilirubinemia (HP:0002908)3.21056623
40Abnormality of serum amino acid levels (HP:0003112)3.18437183
41Abnormality of the intrinsic pathway (HP:0010989)3.17116624
42Hyperbilirubinemia (HP:0002904)3.16178300
43Generalized aminoaciduria (HP:0002909)3.15283958
44Metabolic acidosis (HP:0001942)3.08415708
45Abnormality of complement system (HP:0005339)3.08084045
46Lethargy (HP:0001254)3.02587138
47Hypercholesterolemia (HP:0003124)2.97195554
48Hemorrhage of the eye (HP:0011885)2.91918839
49Ragged-red muscle fibers (HP:0003200)2.90923184
50Abnormality of the Achilles tendon (HP:0005109)2.86876319
51Proximal tubulopathy (HP:0000114)2.85124512
52Purpura (HP:0000979)2.83332322
53Steatorrhea (HP:0002570)2.82415087
54Abnormality of glycolysis (HP:0004366)2.80526322
55Hepatocellular carcinoma (HP:0001402)2.74328040
56Vascular calcification (HP:0004934)2.73488692
57Cerebral edema (HP:0002181)2.71223750
58Achilles tendon contracture (HP:0001771)2.71181702
59Increased purine levels (HP:0004368)2.63415215
60Hyperuricemia (HP:0002149)2.63415215
61Reticulocytosis (HP:0001923)2.59442458
62Trismus (HP:0000211)2.58098904
63Vomiting (HP:0002013)2.53733088
64Alkalosis (HP:0001948)2.51630431
65Irritability (HP:0000737)2.51540282
66Spastic diplegia (HP:0001264)2.50554638
67Hypoglycemic seizures (HP:0002173)2.46703568
68Progressive muscle weakness (HP:0003323)2.45952802
69Abnormality of urine glucose concentration (HP:0011016)2.42995304
70Glycosuria (HP:0003076)2.42995304
71Increased serum ferritin (HP:0003281)2.41303923
72Cardiovascular calcification (HP:0011915)2.40173779
73Increased serum pyruvate (HP:0003542)2.39773353
74Malnutrition (HP:0004395)2.39514753
75Late onset (HP:0003584)2.39424819
76Abnormality of proline metabolism (HP:0010907)2.39151206
77Hydroxyprolinuria (HP:0003080)2.39151206
78Neonatal onset (HP:0003623)2.39119297
79Abnormality of carpal bone ossification (HP:0006257)2.37315740
80Microvesicular hepatic steatosis (HP:0001414)2.34521335
81Skin nodule (HP:0200036)2.34104740
82Myocardial infarction (HP:0001658)2.33852391
83Brushfield spots (HP:0001088)2.33325885
84Hyperacusis (HP:0010780)2.30565859
85Opisthotonus (HP:0002179)2.28727873
86Hypertensive crisis (HP:0100735)2.28260613
87Upper limb amyotrophy (HP:0009129)2.27350468
88Distal upper limb amyotrophy (HP:0007149)2.27350468
89Pancreatitis (HP:0001733)2.26953903
90Sensorimotor neuropathy (HP:0007141)2.26336399
91Dysostosis multiplex (HP:0000943)2.25638294
92Protrusio acetabuli (HP:0003179)2.23382412
93Enlarged kidneys (HP:0000105)2.23131885
94Systemic lupus erythematosus (HP:0002725)2.22875535
95Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19801982
96Seborrheic dermatitis (HP:0001051)2.19743467
97Spontaneous abortion (HP:0005268)2.15260569
98Rough bone trabeculation (HP:0100670)2.14166914
99Rickets (HP:0002748)2.12680865
100Abnormality of reticulocytes (HP:0004312)2.11978361
101Petechiae (HP:0000967)2.11952507
102Loss of speech (HP:0002371)2.10706469
103Abnormal enzyme/coenzyme activity (HP:0012379)2.09202639
104Abnormal gallbladder morphology (HP:0012437)2.06923490
105Menorrhagia (HP:0000132)2.05670199
106Hypochromic microcytic anemia (HP:0004840)2.04552970
107Abnormal gallbladder physiology (HP:0012438)2.04198521
108Cholecystitis (HP:0001082)2.04198521
109Methylmalonic aciduria (HP:0012120)2.04138250
110Mitral stenosis (HP:0001718)2.03638359
111Abnormal cartilage morphology (HP:0002763)2.01647423
112Prolonged neonatal jaundice (HP:0006579)2.01048867
113Cholelithiasis (HP:0001081)2.00296581
114Acanthocytosis (HP:0001927)1.99123520
115Nausea (HP:0002018)1.98923678
116Abnormality of liposaccharide metabolism (HP:0010968)1.96325152
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.96325152
118Abnormality of glycolipid metabolism (HP:0010969)1.96325152
119Hypokinesia (HP:0002375)1.95510195
120Hepatic necrosis (HP:0002605)1.94998922
121Nuclear cataract (HP:0100018)1.94351729
122Hyperinsulinemic hypoglycemia (HP:0000825)1.92759751
123Abnormal ossification of hand bones (HP:0005921)1.89897260
124Flat acetabular roof (HP:0003180)1.89550145
125Nephrolithiasis (HP:0000787)1.88870918
126Urinary glycosaminoglycan excretion (HP:0003541)1.88698608
127Mucopolysacchariduria (HP:0008155)1.88698608
128Elevated hepatic transaminases (HP:0002910)1.87509790
129Multiple enchondromatosis (HP:0005701)1.87455384
130Hepatosplenomegaly (HP:0001433)1.86983798
131Abnormality of alkaline phosphatase activity (HP:0004379)1.86207390
132Long palpebral fissure (HP:0000637)1.86110865
133Hand muscle atrophy (HP:0009130)1.85322164
134Insomnia (HP:0100785)1.85184900
135Glomerulonephritis (HP:0000099)1.84832083
136Abnormal trabecular bone morphology (HP:0100671)1.84138439
137Abnormal tarsal ossification (HP:0008369)1.83787989
138Abnormality of vitamin metabolism (HP:0100508)1.83430075
139Esophageal varix (HP:0002040)1.82901892
140Small epiphyses (HP:0010585)1.82108913
141Premature ovarian failure (HP:0008209)1.81799989
142Elevated alkaline phosphatase (HP:0003155)1.81126333
143Myopathic facies (HP:0002058)1.81057392
144Abnormality of polysaccharide metabolism (HP:0011012)1.80891375
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80891375
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80891375
147Renal cortical cysts (HP:0000803)1.79072602
148Hyperphosphaturia (HP:0003109)1.77843048
149Polygenic inheritance (HP:0010982)1.77527720
150Abnormality of the gallbladder (HP:0005264)1.77379374
151Abnormality of transition element cation homeostasis (HP:0011030)1.76725188
152Orthostatic hypotension (HP:0001278)1.76495942
153Premature rupture of membranes (HP:0001788)1.76130802
154Fatigue (HP:0012378)1.74346710
155Testicular atrophy (HP:0000029)1.73408581
156Ulnar bowing (HP:0003031)1.72986601
157Nonimmune hydrops fetalis (HP:0001790)1.72940392
158Rhabdomyolysis (HP:0003201)1.72848552
159Back pain (HP:0003418)1.70833545
160Abnormality of macrophages (HP:0004311)1.70832114
161Axonal loss (HP:0003447)1.70828621
162Progressive external ophthalmoplegia (HP:0000590)1.70441405
163Hypertriglyceridemia (HP:0002155)1.69744441
164Truncus arteriosus (HP:0001660)1.69653321
165Distal lower limb amyotrophy (HP:0008944)1.69501661
166Abnormality of the distal phalanges of the toes (HP:0010182)1.68095561
167Vacuolated lymphocytes (HP:0001922)1.68072236
168Centrally nucleated skeletal muscle fibers (HP:0003687)1.67343789
169Hyperthyroidism (HP:0000836)1.66036096
170Abnormality of iron homeostasis (HP:0011031)1.64512151
171Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62063538
172Absent epiphyses (HP:0010577)1.62063538
173Abnormality of the thoracic spine (HP:0100711)1.62035479
174Deviation of the thumb (HP:0009603)1.61349199
175Abnormality of the tricuspid valve (HP:0001702)1.59478583
176Neonatal death (HP:0003811)1.57884936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK8.29422971
2ERN14.28696702
3SIK13.77878684
4FGFR43.61625136
5SMG13.37623817
6WNK32.93902681
7TRIB32.53771818
8PRPF4B2.52198893
9WNK42.46687773
10FLT32.38033991
11INSRR2.33285723
12MST1R2.31378519
13TAOK32.22768627
14VRK22.09827791
15PKN22.09344574
16TAOK21.98452203
17CDK121.96066605
18OXSR11.94423128
19ERBB41.90400267
20TESK11.89085936
21ARAF1.64131736
22MAPK111.58764073
23PIM21.49375531
24PIK3CG1.47724046
25MET1.43342557
26PAK41.40992813
27PTK61.39060188
28MAP2K41.36591009
29ABL21.34608958
30KDR1.33923065
31EPHB11.28937339
32MAP2K31.23775631
33MAPK151.23564745
34TYK21.22260256
35SCYL21.19448373
36NEK11.18640345
37STK161.16535615
38PDK31.16144815
39PDK41.16144815
40GRK61.12809708
41PINK11.12611868
42MAP3K111.07590262
43NME11.06373022
44NEK91.04556107
45BUB11.03427460
46MAPKAPK31.03317271
47MAP3K101.02980536
48MAP3K81.02434907
49CDK71.01155870
50JAK20.96959368
51STK38L0.96101027
52LMTK20.94912689
53MAP3K30.91661021
54STK390.90529999
55PRKAA20.88279038
56MAP2K20.87743640
57TAOK10.86818960
58KSR20.86453157
59MAP3K70.83650100
60FRK0.83433443
61DAPK10.83329237
62CSF1R0.81933993
63TBK10.81363878
64DYRK1B0.80595376
65NME20.79846485
66MAPK40.79274119
67RPS6KB20.77514621
68SIK30.77422224
69MAP3K130.77402855
70BRAF0.74144112
71BMX0.73245271
72FGFR20.72928818
73BRSK10.72677146
74DAPK20.69468651
75CDK80.69077913
76GSK3A0.68542791
77TIE10.67930159
78TGFBR20.67546448
79PTK20.67117353
80TESK20.67072807
81ERBB20.67029385
82MAP2K60.65779994
83PRKCZ0.65208761
84LIMK10.62560195
85RIPK40.61985994
86AURKA0.61917438
87PDGFRA0.61197897
88IRAK40.60543387
89PRKACG0.58244047
90CAMK1D0.57791078
91PRKAA10.56602785
92SIK20.56366153
93PAK10.54598170
94SRPK10.54224534
95LRRK20.53685203
96CDK90.53489568
97CDC42BPA0.53164085
98PDPK10.52495356
99PRKD20.52317575
100IRAK20.51884146
101ILK0.51689756
102AKT20.51363400
103IRAK30.51161523
104MAP4K10.49982827
105CSNK1G10.48802064
106STK100.48287307
107JAK10.47274670
108RAF10.47046791
109CDK60.45975619
110TTK0.45766202
111MAP2K10.44510250
112ALK0.44474141
113MAPK120.44359225
114ICK0.44008665
115MAP3K90.43314505
116MAPKAPK20.43241115
117ZAP700.42954736
118CAMK2G0.41387331
119CDK40.41362165
120KIT0.41005146
121RIPK10.40693645
122SGK4940.40433319
123SGK2230.40433319
124MARK20.39923234
125TGFBR10.39852996
126CSK0.39162521
127FGFR30.38904630
128LATS20.38647983
129EIF2AK10.38404300
130PRKG20.37102510
131CHEK10.36953623
132MTOR0.36674379
133NTRK10.36178615
134PDK20.35329701
135PRKD30.35264439
136JAK30.34646329
137PRKCI0.34357114
138CDK11A0.33688149
139IGF1R0.33596266
140MOS0.33483049
141CSNK1G30.33274415
142LATS10.32801648
143EIF2AK30.31413717
144BTK0.31332493
145EEF2K0.31331250
146PRKCQ0.29454700
147PDK10.29222728
148RET0.26455319
149MAP3K60.24315323
150MAP3K10.23933355
151MAP3K20.23743847
152EPHB20.23528312
153EPHA20.20239829
154EGFR0.19801365
155ACVR1B0.19061767
156PBK0.19030774
157SGK30.18479719

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93838236
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26209463
3Nitrogen metabolism_Homo sapiens_hsa009103.04042231
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.89867014
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.87600734
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82652187
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70627352
8Fatty acid degradation_Homo sapiens_hsa000712.68130489
9Tryptophan metabolism_Homo sapiens_hsa003802.63449621
10Arginine biosynthesis_Homo sapiens_hsa002202.61352666
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58182157
12Butanoate metabolism_Homo sapiens_hsa006502.47058860
13Propanoate metabolism_Homo sapiens_hsa006402.41480657
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26809577
15Peroxisome_Homo sapiens_hsa041462.26555443
16DNA replication_Homo sapiens_hsa030302.16957892
17Complement and coagulation cascades_Homo sapiens_hsa046102.12390243
18Fatty acid metabolism_Homo sapiens_hsa012122.04887645
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03909132
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95890487
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92608135
22PPAR signaling pathway_Homo sapiens_hsa033201.89735211
23Base excision repair_Homo sapiens_hsa034101.86664810
24beta-Alanine metabolism_Homo sapiens_hsa004101.83969645
25Histidine metabolism_Homo sapiens_hsa003401.80189042
26Pyruvate metabolism_Homo sapiens_hsa006201.73725966
27Chemical carcinogenesis_Homo sapiens_hsa052041.72185984
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70739834
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.68526685
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.67777030
31Selenocompound metabolism_Homo sapiens_hsa004501.63922746
32Sulfur metabolism_Homo sapiens_hsa009201.63362658
33Fatty acid elongation_Homo sapiens_hsa000621.57155858
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55192940
35* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53147198
36Proteasome_Homo sapiens_hsa030501.50782896
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.47421305
38Retinol metabolism_Homo sapiens_hsa008301.46506797
39Caffeine metabolism_Homo sapiens_hsa002321.46118276
40N-Glycan biosynthesis_Homo sapiens_hsa005101.45243240
41Folate biosynthesis_Homo sapiens_hsa007901.43729134
42Ribosome_Homo sapiens_hsa030101.43169639
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42319345
44Carbon metabolism_Homo sapiens_hsa012001.41852639
45Bile secretion_Homo sapiens_hsa049761.40371556
46Phenylalanine metabolism_Homo sapiens_hsa003601.39043513
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.35110409
48Biosynthesis of amino acids_Homo sapiens_hsa012301.31341386
49Spliceosome_Homo sapiens_hsa030401.29551158
50Tyrosine metabolism_Homo sapiens_hsa003501.26459080
51Starch and sucrose metabolism_Homo sapiens_hsa005001.23948303
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23843012
53Staphylococcus aureus infection_Homo sapiens_hsa051501.23784451
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22353135
55Bladder cancer_Homo sapiens_hsa052191.18691156
56Steroid biosynthesis_Homo sapiens_hsa001001.17796833
57Sulfur relay system_Homo sapiens_hsa041221.17372376
58Fat digestion and absorption_Homo sapiens_hsa049751.13373610
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12508413
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12294055
61Maturity onset diabetes of the young_Homo sapiens_hsa049501.11882878
62Arginine and proline metabolism_Homo sapiens_hsa003301.07287926
63ABC transporters_Homo sapiens_hsa020101.01452357
64Vitamin digestion and absorption_Homo sapiens_hsa049770.99040038
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95409010
66Glutathione metabolism_Homo sapiens_hsa004800.92707532
67Vibrio cholerae infection_Homo sapiens_hsa051100.90523014
68Mismatch repair_Homo sapiens_hsa034300.90302360
69Acute myeloid leukemia_Homo sapiens_hsa052210.88119280
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86555752
71Chronic myeloid leukemia_Homo sapiens_hsa052200.85921762
72Vitamin B6 metabolism_Homo sapiens_hsa007500.85862456
73Glycerolipid metabolism_Homo sapiens_hsa005610.85507378
74Lysine degradation_Homo sapiens_hsa003100.83686919
75One carbon pool by folate_Homo sapiens_hsa006700.76901764
76Pentose phosphate pathway_Homo sapiens_hsa000300.75646439
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74901623
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69505628
79Nucleotide excision repair_Homo sapiens_hsa034200.67858820
80RNA transport_Homo sapiens_hsa030130.67679785
81Thyroid cancer_Homo sapiens_hsa052160.65565886
82Shigellosis_Homo sapiens_hsa051310.63908014
83Non-small cell lung cancer_Homo sapiens_hsa052230.61128865
84Pancreatic cancer_Homo sapiens_hsa052120.61098914
85Apoptosis_Homo sapiens_hsa042100.60868279
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58213752
87* Metabolic pathways_Homo sapiens_hsa011000.57976277
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55910013
89VEGF signaling pathway_Homo sapiens_hsa043700.55527003
90Fatty acid biosynthesis_Homo sapiens_hsa000610.52430197
91Cell cycle_Homo sapiens_hsa041100.51792780
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51671022
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50325562
94Epstein-Barr virus infection_Homo sapiens_hsa051690.45949787
95Hepatitis C_Homo sapiens_hsa051600.45741352
96Fructose and mannose metabolism_Homo sapiens_hsa000510.45050034
97Notch signaling pathway_Homo sapiens_hsa043300.44253766
98Herpes simplex infection_Homo sapiens_hsa051680.42889532
99Sphingolipid metabolism_Homo sapiens_hsa006000.41354122
100mRNA surveillance pathway_Homo sapiens_hsa030150.39549627
101HIF-1 signaling pathway_Homo sapiens_hsa040660.36749585
102Galactose metabolism_Homo sapiens_hsa000520.34704590
103Hepatitis B_Homo sapiens_hsa051610.33754268
104Influenza A_Homo sapiens_hsa051640.33656598
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33415869
106Salmonella infection_Homo sapiens_hsa051320.32579552
107Viral carcinogenesis_Homo sapiens_hsa052030.30047109
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29705178
109Endocytosis_Homo sapiens_hsa041440.29242292
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28887617
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28125464
112Small cell lung cancer_Homo sapiens_hsa052220.27460214
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26090477
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25167003
115Pertussis_Homo sapiens_hsa051330.24898443
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.20785722
117Linoleic acid metabolism_Homo sapiens_hsa005910.20445983
118Insulin resistance_Homo sapiens_hsa049310.18902570
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18030046
120Prion diseases_Homo sapiens_hsa050200.14677997
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.14456072
122AMPK signaling pathway_Homo sapiens_hsa041520.07837766
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05978770
124Glucagon signaling pathway_Homo sapiens_hsa049220.04047962
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.03657940
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1652905
127Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1595898
128Pyrimidine metabolism_Homo sapiens_hsa00240-0.1581165
129Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1360661
130Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1343123
131Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1302969
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1285334
133Insulin signaling pathway_Homo sapiens_hsa04910-0.1011244
134Protein digestion and absorption_Homo sapiens_hsa04974-0.0815471
135Parkinsons disease_Homo sapiens_hsa05012-0.0731781
136Lysosome_Homo sapiens_hsa04142-0.0713702
137Protein export_Homo sapiens_hsa03060-0.0681107
138Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0363051
139Renin-angiotensin system_Homo sapiens_hsa04614-0.0351994
140Other glycan degradation_Homo sapiens_hsa00511-0.0219473
141Regulation of autophagy_Homo sapiens_hsa04140-0.0146835
142Oxidative phosphorylation_Homo sapiens_hsa00190-0.0113543
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0002228

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