COBL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)4.69331087
2intestinal absorption (GO:0050892)4.55888439
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.52751542
4angiotensin maturation (GO:0002003)4.49088263
5anterior/posterior axis specification, embryo (GO:0008595)4.34368699
6synaptic vesicle maturation (GO:0016188)4.08181381
7glutamate secretion (GO:0014047)4.07394977
8L-amino acid import (GO:0043092)4.00257419
9vocalization behavior (GO:0071625)3.98173814
10sarcoplasmic reticulum calcium ion transport (GO:0070296)3.89264018
11cell communication by electrical coupling (GO:0010644)3.88165587
12regulation of cell communication by electrical coupling (GO:0010649)3.85921792
13desmosome organization (GO:0002934)3.85780450
14bundle of His cell to Purkinje myocyte communication (GO:0086069)3.85240734
15cytoskeletal anchoring at plasma membrane (GO:0007016)3.83201357
16axon ensheathment in central nervous system (GO:0032291)3.80526974
17central nervous system myelination (GO:0022010)3.80526974
18amino acid import (GO:0043090)3.78435464
19cerebellar granule cell differentiation (GO:0021707)3.76355555
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.72544106
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.68219294
22cellular sodium ion homeostasis (GO:0006883)3.65896059
23potassium ion import (GO:0010107)3.61410335
24regulation of bile acid biosynthetic process (GO:0070857)3.61304387
25potassium ion homeostasis (GO:0055075)3.60890892
26positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.58618674
27regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.47776293
28muscle filament sliding (GO:0030049)3.46567090
29actin-myosin filament sliding (GO:0033275)3.46567090
30layer formation in cerebral cortex (GO:0021819)3.45875781
31intestinal epithelial cell development (GO:0060576)3.41888196
32hemidesmosome assembly (GO:0031581)3.36741469
33proline transport (GO:0015824)3.36597639
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.36072712
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.35976943
36cell communication involved in cardiac conduction (GO:0086065)3.32455431
37locomotory exploration behavior (GO:0035641)3.32212370
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28219321
39striated muscle contraction (GO:0006941)3.23346788
40regulation of gene silencing by RNA (GO:0060966)3.22102742
41regulation of posttranscriptional gene silencing (GO:0060147)3.22102742
42regulation of gene silencing by miRNA (GO:0060964)3.22102742
43skeletal muscle contraction (GO:0003009)3.21933212
44drug catabolic process (GO:0042737)3.19704026
45synaptic vesicle exocytosis (GO:0016079)3.19466169
46NADH metabolic process (GO:0006734)3.16647270
47regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.11024898
48cardiac muscle contraction (GO:0060048)3.10095140
49creatine metabolic process (GO:0006600)3.07358533
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06820997
51hormone catabolic process (GO:0042447)3.06227917
52regulation of synaptic vesicle exocytosis (GO:2000300)3.05773873
53regulation of synapse maturation (GO:0090128)3.04997784
54negative regulation of dendrite morphogenesis (GO:0050774)3.01968411
55negative regulation of sodium ion transport (GO:0010766)3.01793972
56regulation of ARF protein signal transduction (GO:0032012)2.96999434
57regulation of actin filament-based movement (GO:1903115)2.96391543
58regulation of clathrin-mediated endocytosis (GO:2000369)2.95437320
59negative regulation of hormone biosynthetic process (GO:0032353)2.93992389
60negative regulation of hormone metabolic process (GO:0032351)2.93992389
61detection of calcium ion (GO:0005513)2.93341756
62sodium ion export (GO:0071436)2.93210948
63regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.93082611
64regulation of hippo signaling (GO:0035330)2.90577328
65neurotransmitter uptake (GO:0001504)2.90153972
66regulation of water loss via skin (GO:0033561)2.89714109
67regulation of cholesterol homeostasis (GO:2000188)2.89368416
68regulation of relaxation of muscle (GO:1901077)2.89286266
69neuronal ion channel clustering (GO:0045161)2.87759437
70regulation of neurotransmitter levels (GO:0001505)2.86639389
71regulation of synaptic plasticity (GO:0048167)2.84970435
72neurotransmitter secretion (GO:0007269)2.84882216
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.84228790
74cell migration in hindbrain (GO:0021535)2.84175274
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83478150
76regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.82330971
77actin-mediated cell contraction (GO:0070252)2.82055008
78cell-cell junction maintenance (GO:0045217)2.78894021
79cell junction maintenance (GO:0034331)2.78637198
80cellular potassium ion homeostasis (GO:0030007)2.77695669
81regulation of voltage-gated calcium channel activity (GO:1901385)2.75818268
82phosphate ion transmembrane transport (GO:0035435)2.75408176
83establishment of skin barrier (GO:0061436)2.74623097
84regulation of glutamate receptor signaling pathway (GO:1900449)2.74405339
85epithelial cell-cell adhesion (GO:0090136)2.73646849
86dendritic spine morphogenesis (GO:0060997)2.73195680
87regulation of sodium ion transmembrane transporter activity (GO:2000649)2.73121959
88cardiac conduction (GO:0061337)2.72722092
89positive regulation of sodium ion transport (GO:0010765)2.72625853
90sodium ion homeostasis (GO:0055078)2.71166247
91regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.70128883
92regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70045837
93response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.69804287
94regulation of membrane repolarization (GO:0060306)2.68534972
95positive regulation of dendritic spine development (GO:0060999)2.67605123
96chemosensory behavior (GO:0007635)2.66657737
97neuromuscular process controlling balance (GO:0050885)2.66432454
98ventricular cardiac muscle cell action potential (GO:0086005)2.63455233
99plasma membrane repair (GO:0001778)2.62874799
100response to histamine (GO:0034776)2.61189211
101cardiac muscle hypertrophy (GO:0003300)2.60506223
102regulation of heart rate by cardiac conduction (GO:0086091)2.60480927
103regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59312894
104myofibril assembly (GO:0030239)2.58003456
105membrane depolarization during action potential (GO:0086010)2.57038750
106myelin maintenance (GO:0043217)2.56961025
107positive regulation of membrane potential (GO:0045838)2.54096525
108establishment of apical/basal cell polarity (GO:0035089)2.53293940
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50717290
110activation of protein kinase A activity (GO:0034199)2.50381196
111actin filament depolymerization (GO:0030042)2.50300442
112regulation of calcium ion transmembrane transport (GO:1903169)2.50167067
113regulation of calcium ion transmembrane transporter activity (GO:1901019)2.50167067
114regulation of neuronal synaptic plasticity (GO:0048168)2.49732646
115regulation of cardiac muscle cell contraction (GO:0086004)2.49693084
116acid secretion (GO:0046717)2.49654946
117postsynaptic membrane organization (GO:0001941)2.49503921
118regulation of synaptic vesicle transport (GO:1902803)2.49476930
119positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.49123525
120acidic amino acid transport (GO:0015800)2.48061503
121flavonoid metabolic process (GO:0009812)2.46832480
122determination of adult lifespan (GO:0008340)2.45893848
123membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.45543860
124regulation of neurotransmitter secretion (GO:0046928)2.45540833
125negative regulation of sterol transport (GO:0032372)2.45291954
126negative regulation of cholesterol transport (GO:0032375)2.45291954
127regulation of dendritic spine morphogenesis (GO:0061001)2.44946611
128neuromuscular synaptic transmission (GO:0007274)2.44825840
129positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.44431223
130positive regulation of synapse maturation (GO:0090129)2.44191023
131striated muscle hypertrophy (GO:0014897)2.43693493
132long-term memory (GO:0007616)2.43679645
133muscle hypertrophy in response to stress (GO:0003299)2.43609313
134glutamate metabolic process (GO:0006536)2.43304772
135establishment of monopolar cell polarity (GO:0061162)2.42527382
136establishment or maintenance of monopolar cell polarity (GO:0061339)2.42527382
137dicarboxylic acid biosynthetic process (GO:0043650)2.41333140
138exogenous drug catabolic process (GO:0042738)2.40634359
139protein localization to synapse (GO:0035418)2.40477484
140regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.39748076
141neuronal action potential propagation (GO:0019227)2.38994346
142phosphate ion transport (GO:0006817)2.35538219
143establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.34731643
144vesicle transport along microtubule (GO:0047496)2.34708844
145drinking behavior (GO:0042756)2.33576028
146triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.32998074
147negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.32628549
148phospholipid efflux (GO:0033700)2.30266435
149regulation of transforming growth factor beta1 production (GO:0032908)2.29770697
150regulation of sodium ion transmembrane transport (GO:1902305)2.29485711
151vitamin A metabolic process (GO:0006776)2.28761460
152exploration behavior (GO:0035640)2.28428830
153neurotransmitter-gated ion channel clustering (GO:0072578)2.26371656
154cardiac muscle cell action potential involved in contraction (GO:0086002)2.25989901
155cardiac muscle cell action potential (GO:0086001)2.25022373
156alanine transport (GO:0032328)2.23954454
157neurotransmitter transport (GO:0006836)2.22541608
158membrane repolarization during action potential (GO:0086011)2.21580656
159trophectodermal cell differentiation (GO:0001829)2.21169670
160L-alpha-amino acid transmembrane transport (GO:1902475)2.18851791
161epoxygenase P450 pathway (GO:0019373)2.17293933
162endocardial cushion development (GO:0003197)2.16709519
163cysteine metabolic process (GO:0006534)2.15256981
164modified amino acid transport (GO:0072337)2.15069164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.46145884
2* SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.35887944
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.75050078
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.75050078
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.75050078
6* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50693736
7* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.46497613
8* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.40994641
9* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19334568
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18171253
11ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.16024415
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.14548722
13* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.10789127
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08248305
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07726869
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02543526
17ZNF263_19887448_ChIP-Seq_K562_Human1.98613072
18* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96794944
19* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.91550168
20EZH2_22144423_ChIP-Seq_EOC_Human1.90907404
21* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.87001646
22* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.86915989
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.86803211
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.86392350
25* RARB_27405468_Chip-Seq_BRAIN_Mouse1.78600450
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.75670344
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.75564838
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73560113
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.73175016
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72368256
31* SALL1_21062744_ChIP-ChIP_HESCs_Human1.71320730
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70047531
33* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69987829
34* CDX2_20551321_ChIP-Seq_CACO-2_Human1.68599722
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66806077
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64220418
37* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62758930
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59994412
39* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56718056
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56499127
41DROSHA_22980978_ChIP-Seq_HELA_Human1.56293920
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.52412517
43POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52030586
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52017646
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.50800172
46PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.49450084
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48653327
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47117408
49* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46111992
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43968512
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37442165
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33665261
53* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32930196
54AHR_22903824_ChIP-Seq_MCF-7_Human1.32073733
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.29206827
56TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.29186481
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.29036179
58REST_21632747_ChIP-Seq_MESCs_Mouse1.28159107
59TET1_21490601_ChIP-Seq_MESCs_Mouse1.27425412
60* RXR_22158963_ChIP-Seq_LIVER_Mouse1.27111633
61LXR_22292898_ChIP-Seq_THP-1_Human1.26801254
62SMC4_20622854_ChIP-Seq_HELA_Human1.26055975
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25974401
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24917111
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.24510169
66* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23289675
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21491065
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20185872
69* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19899488
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18290612
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17871440
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.17808324
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.16589310
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16232071
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.16002740
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.16002740
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.15785827
78KDM2B_26808549_Chip-Seq_K562_Human1.15293927
79* NANOG_16518401_ChIP-PET_MESCs_Mouse1.15069311
80* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14212223
81PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13259203
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12138569
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11659367
84KLF5_25053715_ChIP-Seq_YYC3_Human1.11421146
85* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.10988466
86* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10342883
87* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10292322
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09581158
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.09384625
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09229807
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.07740625
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07629186
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07029543
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05954667
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.05896974
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.05875918
97* AR_19668381_ChIP-Seq_PC3_Human1.05399385
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05263450
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04951353
100* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04217974
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03787535
102NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03227768
103* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02302987
104* REST_18959480_ChIP-ChIP_MESCs_Mouse1.00943823
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.00630795
106CTCF_27219007_Chip-Seq_Bcells_Human0.97705656
107CREB1_26743006_Chip-Seq_LNCaP_Human0.97390817
108GBX2_23144817_ChIP-Seq_PC3_Human0.97045248
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96368335
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95033832
111SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94585065
112CLOCK_20551151_ChIP-Seq_293T_Human0.93631241
113* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93431311
114TP53_16413492_ChIP-PET_HCT116_Human0.93311336
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.93196514
116* GATA6_25053715_ChIP-Seq_YYC3_Human0.93192410
117AR_21572438_ChIP-Seq_LNCaP_Human0.92770635
118FOXA2_19822575_ChIP-Seq_HepG2_Human0.92577638
119RACK7_27058665_Chip-Seq_MCF-7_Human0.92553114
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92208932
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92165385
122* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92143620
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91662995
124EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91570247
125RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91570247
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90652851
127TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89301831
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89223514
129SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.89127106
130* SOX2_21211035_ChIP-Seq_LN229_Gbm0.88753774
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88612156
132CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87834926
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87332550
134* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87173392
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86798101
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86676856
137* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86490432
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86455520
139* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86231609
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85457648
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.84396411
142* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84383980
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83804393
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83105274
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83089876

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.86590543
2MP0005360_urolithiasis4.39244936
3MP0002822_catalepsy3.74079504
4MP0004859_abnormal_synaptic_plasticity3.37758088
5MP0002796_impaired_skin_barrier3.22460491
6MP0003283_abnormal_digestive_organ2.98596661
7MP0004270_analgesia2.94082482
8MP0005085_abnormal_gallbladder_physiolo2.85308921
9MP0005423_abnormal_somatic_nervous2.74576312
10MP0003941_abnormal_skin_development2.57949350
11MP0001666_abnormal_nutrient_absorption2.53427639
12MP0004264_abnormal_extraembryonic_tissu2.43054139
13MP0004145_abnormal_muscle_electrophysio2.39035066
14MP0002139_abnormal_hepatobiliary_system2.33861920
15MP0002254_reproductive_system_inflammat2.33013289
16MP0000749_muscle_degeneration2.23485453
17MP0008875_abnormal_xenobiotic_pharmacok2.08783069
18MP0003705_abnormal_hypodermis_morpholog1.93038209
19MP0003123_paternal_imprinting1.92572733
20MP0004036_abnormal_muscle_relaxation1.91084406
21MP0003635_abnormal_synaptic_transmissio1.85778021
22MP0000747_muscle_weakness1.84861302
23MP0008569_lethality_at_weaning1.79320483
24MP0009780_abnormal_chondrocyte_physiolo1.78034421
25MP0004858_abnormal_nervous_system1.77465172
26MP0005501_abnormal_skin_physiology1.77437455
27MP0004885_abnormal_endolymph1.75542927
28MP0003690_abnormal_glial_cell1.73169615
29MP0003806_abnormal_nucleotide_metabolis1.69997457
30MP0003646_muscle_fatigue1.69066481
31MP0004087_abnormal_muscle_fiber1.64466782
32MP0003252_abnormal_bile_duct1.60959223
33MP0010352_gastrointestinal_tract_polyps1.59647858
34MP0002063_abnormal_learning/memory/cond1.59261068
35MP0001849_ear_inflammation1.55268401
36MP0002653_abnormal_ependyma_morphology1.54369981
37MP0000566_synostosis1.50825438
38MP0005365_abnormal_bile_salt1.50196638
39MP0000467_abnormal_esophagus_morphology1.49598575
40MP0000462_abnormal_digestive_system1.42971344
41MP0005646_abnormal_pituitary_gland1.42194634
42MP0003879_abnormal_hair_cell1.39933503
43MP0004215_abnormal_myocardial_fiber1.39821198
44MP0010678_abnormal_skin_adnexa1.39018595
45MP0000537_abnormal_urethra_morphology1.38754276
46MP0004130_abnormal_muscle_cell1.38586216
47MP0009745_abnormal_behavioral_response1.38041367
48MP0000920_abnormal_myelination1.37899352
49MP0004084_abnormal_cardiac_muscle1.37022601
50MP0010329_abnormal_lipoprotein_level1.36348281
51MP0004019_abnormal_vitamin_homeostasis1.32844147
52MP0002734_abnormal_mechanical_nocicepti1.31751998
53MP0003880_abnormal_central_pattern1.31462300
54MP0003119_abnormal_digestive_system1.30669351
55MP0000759_abnormal_skeletal_muscle1.26974078
56MP0001968_abnormal_touch/_nociception1.26735496
57MP0002735_abnormal_chemical_nociception1.26601972
58MP0002106_abnormal_muscle_physiology1.24134422
59MP0002572_abnormal_emotion/affect_behav1.20187359
60MP0005620_abnormal_muscle_contractility1.20048280
61MP0008872_abnormal_physiological_respon1.19695688
62MP0001346_abnormal_lacrimal_gland1.19277776
63MP0005330_cardiomyopathy1.17810979
64MP0000579_abnormal_nail_morphology1.17529824
65MP0002733_abnormal_thermal_nociception1.17387080
66MP0001984_abnormal_olfaction1.16621312
67MP0001502_abnormal_circadian_rhythm1.16021770
68MP0002066_abnormal_motor_capabilities/c1.15499391
69MP0003633_abnormal_nervous_system1.15167067
70MP0005670_abnormal_white_adipose1.14496914
71MP0002064_seizures1.14326224
72MP0005369_muscle_phenotype1.13692527
73MP0002067_abnormal_sensory_capabilities1.12202867
74MP0004043_abnormal_pH_regulation1.10763953
75MP0005367_renal/urinary_system_phenotyp1.09029726
76MP0000516_abnormal_urinary_system1.09029726
77MP0009053_abnormal_anal_canal1.08474141
78MP0001486_abnormal_startle_reflex1.07279508
79MP0001440_abnormal_grooming_behavior1.06888015
80MP0003453_abnormal_keratinocyte_physiol1.03337757
81MP0008961_abnormal_basal_metabolism1.03200945
82MP0003137_abnormal_impulse_conducting1.03130892
83MP0004484_altered_response_of1.03059858
84MP0005409_darkened_coat_color1.01125669
85MP0002972_abnormal_cardiac_muscle1.00641191
86MP0005167_abnormal_blood-brain_barrier0.99967980
87MP0003329_amyloid_beta_deposits0.99629932
88MP0003631_nervous_system_phenotype0.98932102
89MP0009046_muscle_twitch0.98712807
90MP0003634_abnormal_glial_cell0.97152022
91MP0008004_abnormal_stomach_pH0.96388552
92MP0004133_heterotaxia0.96322516
93MP0009672_abnormal_birth_weight0.95701124
94MP0010771_integument_phenotype0.95204718
95MP0004147_increased_porphyrin_level0.95117993
96MP0006138_congestive_heart_failure0.93801666
97MP0005623_abnormal_meninges_morphology0.92785606
98MP0010630_abnormal_cardiac_muscle0.92711257
99MP0004185_abnormal_adipocyte_glucose0.92563715
100MP0000751_myopathy0.90020534
101MP0000534_abnormal_ureter_morphology0.89440200
102MP0003787_abnormal_imprinting0.88074973
103MP0001299_abnormal_eye_distance/0.87885017
104MP0001485_abnormal_pinna_reflex0.87651610
105MP0002882_abnormal_neuron_morphology0.87491124
106MP0002229_neurodegeneration0.87210365
107MP0000762_abnormal_tongue_morphology0.86879668
108MP0002837_dystrophic_cardiac_calcinosis0.85054254
109MP0002272_abnormal_nervous_system0.84795851
110MP0004085_abnormal_heartbeat0.84792778
111MP0004233_abnormal_muscle_weight0.83623775
112MP0003878_abnormal_ear_physiology0.83069300
113MP0005377_hearing/vestibular/ear_phenot0.83069300
114MP0003632_abnormal_nervous_system0.81346194
115MP0005076_abnormal_cell_differentiation0.80893310
116MP0002108_abnormal_muscle_morphology0.80614372
117MP0003566_abnormal_cell_adhesion0.80259776
118MP0001970_abnormal_pain_threshold0.79597477
119MP0002557_abnormal_social/conspecific_i0.79103765
120MP0005666_abnormal_adipose_tissue0.78047564
121MP0002269_muscular_atrophy0.77040997
122MP0001664_abnormal_digestion0.76072791
123MP0000013_abnormal_adipose_tissue0.75286588
124MP0002909_abnormal_adrenal_gland0.75008361
125MP0005248_abnormal_Harderian_gland0.74964762
126MP0005275_abnormal_skin_tensile0.74584562
127MP0001216_abnormal_epidermal_layer0.74579828
128MP0002084_abnormal_developmental_patter0.74356710
129MP0001501_abnormal_sleep_pattern0.74314096
130MP0005451_abnormal_body_composition0.74271507
131MP0000003_abnormal_adipose_tissue0.73281000
132MP0002098_abnormal_vibrissa_morphology0.71704095
133MP0002736_abnormal_nociception_after0.70533019
134MP0001765_abnormal_ion_homeostasis0.70277993
135MP0002332_abnormal_exercise_endurance0.69860902
136MP0002249_abnormal_larynx_morphology0.69548196
137MP0004811_abnormal_neuron_physiology0.69381089
138MP0002876_abnormal_thyroid_physiology0.69026633
139MP0005266_abnormal_metabolism0.68752846
140MP0001963_abnormal_hearing_physiology0.68696750
141MP0005375_adipose_tissue_phenotype0.68141479
142MP0005499_abnormal_olfactory_system0.67532662
143MP0005394_taste/olfaction_phenotype0.67532662
144MP0005386_behavior/neurological_phenoty0.67173385
145MP0004924_abnormal_behavior0.67173385
146MP0001177_atelectasis0.66270003
147MP0005332_abnormal_amino_acid0.66036475
148MP0000955_abnormal_spinal_cord0.65954162
149MP0003890_abnormal_embryonic-extraembry0.65540795
150MP0000778_abnormal_nervous_system0.61397325
151MP0005187_abnormal_penis_morphology0.60688386
152MP0008874_decreased_physiological_sensi0.60674849
153MP0002118_abnormal_lipid_homeostasis0.56528711
154MP0003638_abnormal_response/metabolism_0.56029026
155MP0002086_abnormal_extraembryonic_tissu0.55736239
156MP0010030_abnormal_orbit_morphology0.55511059

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)4.84567621
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.72200286
3Right ventricular cardiomyopathy (HP:0011663)4.67923917
4Nemaline bodies (HP:0003798)4.66362578
5Exercise-induced myalgia (HP:0003738)4.50156330
6Bundle branch block (HP:0011710)4.02237389
7Myokymia (HP:0002411)3.92281220
8Exercise-induced muscle cramps (HP:0003710)3.84085962
9Muscle fiber splitting (HP:0003555)3.48329769
10Type 1 muscle fiber predominance (HP:0003803)3.35598519
11EMG: myopathic abnormalities (HP:0003458)3.28501444
12Muscle hypertrophy of the lower extremities (HP:0008968)3.21589655
13Distal arthrogryposis (HP:0005684)3.21498613
14Calf muscle hypertrophy (HP:0008981)3.09522746
15Abnormality of the lower motor neuron (HP:0002366)3.09194263
16Fetal akinesia sequence (HP:0001989)3.07842137
17Ileus (HP:0002595)3.06230399
18Hypobetalipoproteinemia (HP:0003563)3.03243209
19Ependymoma (HP:0002888)3.02321675
20Obstructive sleep apnea (HP:0002870)2.94773674
21Focal motor seizures (HP:0011153)2.92680604
22Abnormality of glutamine family amino acid metabolism (HP:0010902)2.92436146
23Abnormality of the labia minora (HP:0012880)2.87868857
24Febrile seizures (HP:0002373)2.87838696
25Centrally nucleated skeletal muscle fibers (HP:0003687)2.85878746
26Abnormality of the astrocytes (HP:0100707)2.83236808
27Astrocytoma (HP:0009592)2.83236808
28Heart block (HP:0012722)2.81722580
29Malnutrition (HP:0004395)2.81114439
30Focal seizures (HP:0007359)2.75655335
31Akinesia (HP:0002304)2.74328195
32Hyporeflexia of lower limbs (HP:0002600)2.70104550
33Abnormal atrioventricular conduction (HP:0005150)2.66246566
34Abnormality of the calf musculature (HP:0001430)2.65367446
35Difficulty running (HP:0009046)2.62509873
36Intrahepatic cholestasis (HP:0001406)2.61789186
37Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54784254
38Curly hair (HP:0002212)2.53771903
39Atonic seizures (HP:0010819)2.51756387
40Subaortic stenosis (HP:0001682)2.47772477
41Abnormality of the left ventricular outflow tract (HP:0011103)2.47772477
42Milia (HP:0001056)2.43471625
43Lower limb amyotrophy (HP:0007210)2.42583193
44Ventricular fibrillation (HP:0001663)2.41430449
45Neurofibrillary tangles (HP:0002185)2.40336552
46Biliary tract neoplasm (HP:0100574)2.37583984
47Visual hallucinations (HP:0002367)2.37224804
48Neck muscle weakness (HP:0000467)2.36812929
49Abnormality of the 1st metacarpal (HP:0010009)2.35794858
50Lip pit (HP:0100267)2.35424441
51Shawl scrotum (HP:0000049)2.33598687
52Esophageal atresia (HP:0002032)2.33583270
53Myoglobinuria (HP:0002913)2.29813157
54Gout (HP:0001997)2.27506654
55Hyperkalemia (HP:0002153)2.27103389
56Dysmetria (HP:0001310)2.26419659
57Spastic gait (HP:0002064)2.25794075
58Abnormality of the salivary glands (HP:0010286)2.25467568
59Atrioventricular block (HP:0001678)2.24441121
60Ventricular tachycardia (HP:0004756)2.19951440
61Abnormality of the Achilles tendon (HP:0005109)2.19462107
62Supranuclear gaze palsy (HP:0000605)2.18687645
63Dysmetric saccades (HP:0000641)2.15736195
64Achilles tendon contracture (HP:0001771)2.15189441
65Muscle stiffness (HP:0003552)2.13793659
66Popliteal pterygium (HP:0009756)2.12995908
67Ankyloglossia (HP:0010296)2.12461781
68Plantar hyperkeratosis (HP:0007556)2.09809971
69Rib fusion (HP:0000902)2.09627958
70Urethral obstruction (HP:0000796)2.09040734
71Resting tremor (HP:0002322)2.08067134
72Increased circulating renin level (HP:0000848)2.07786396
73Foot dorsiflexor weakness (HP:0009027)2.07336054
74Diplopia (HP:0000651)2.07092952
75Abnormality of binocular vision (HP:0011514)2.07092952
76Vertebral clefting (HP:0008428)2.06505608
77Rhabdomyolysis (HP:0003201)2.06265712
78Urinary bladder sphincter dysfunction (HP:0002839)2.05453930
79Short humerus (HP:0005792)2.05270606
80Dysdiadochokinesis (HP:0002075)2.03822228
81Cerebral inclusion bodies (HP:0100314)2.03682809
82Abnormality of the foot musculature (HP:0001436)2.02686533
83Woolly hair (HP:0002224)2.02103462
84Hyperglycinuria (HP:0003108)2.00880290
85Widely patent fontanelles and sutures (HP:0004492)2.00487103
86Calcaneovalgus deformity (HP:0001848)2.00232852
87Impaired vibration sensation in the lower limbs (HP:0002166)1.99268749
88Pili torti (HP:0003777)1.97964760
89Fragile nails (HP:0001808)1.97425136
90Abnormal social behavior (HP:0012433)1.97241494
91Impaired social interactions (HP:0000735)1.97241494
92Intention tremor (HP:0002080)1.94822428
93Depression (HP:0000716)1.94342314
94Distal lower limb amyotrophy (HP:0008944)1.93733695
95Tetraplegia (HP:0002445)1.92884642
96EMG: neuropathic changes (HP:0003445)1.92404135
97Ulnar deviation of the wrist (HP:0003049)1.91239863
98Truncal ataxia (HP:0002078)1.91069188
99Hypolipoproteinemia (HP:0010981)1.89738412
100Distal lower limb muscle weakness (HP:0009053)1.89346075
101Relative macrocephaly (HP:0004482)1.88527801
102Areflexia of lower limbs (HP:0002522)1.87995864
103Asymmetric septal hypertrophy (HP:0001670)1.87410441
104Frequent falls (HP:0002359)1.87033874
105Abnormality of skeletal muscle fiber size (HP:0012084)1.86948103
106Increased connective tissue (HP:0009025)1.85981808
107Urinary urgency (HP:0000012)1.85201913
108Action tremor (HP:0002345)1.84828728
109Myotonia (HP:0002486)1.84828452
110Clonus (HP:0002169)1.83925879
111Short 1st metacarpal (HP:0010034)1.83779205
112Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83779205
113Epileptic encephalopathy (HP:0200134)1.83293065
114Lower limb muscle weakness (HP:0007340)1.83149023
115Dehydration (HP:0001944)1.82281789
116Scanning speech (HP:0002168)1.82257111
117Aplasia involving bones of the upper limbs (HP:0009823)1.81603618
118Aplasia of the phalanges of the hand (HP:0009802)1.81603618
119Aplasia involving bones of the extremities (HP:0009825)1.81603618
120Status epilepticus (HP:0002133)1.81107313
121Glioma (HP:0009733)1.81027122
122Dialeptic seizures (HP:0011146)1.80668939
123Acanthocytosis (HP:0001927)1.80629458
124Upper limb amyotrophy (HP:0009129)1.78734983
125Distal upper limb amyotrophy (HP:0007149)1.78734983
126Aplasia/hypoplasia of the humerus (HP:0006507)1.78079963
127Onycholysis (HP:0001806)1.76991667
128Anxiety (HP:0000739)1.76555851
129Mildly elevated creatine phosphokinase (HP:0008180)1.76302146
130Bulbar palsy (HP:0001283)1.75317011
131Hydroxyprolinuria (HP:0003080)1.75227304
132Abnormality of proline metabolism (HP:0010907)1.75227304
133Cerebral hypomyelination (HP:0006808)1.75014833
134Rigidity (HP:0002063)1.74236461
135Rimmed vacuoles (HP:0003805)1.73369117
136Epidermoid cyst (HP:0200040)1.73101225
137Facial shape deformation (HP:0011334)1.72684332
138Potter facies (HP:0002009)1.72684332
139Increased variability in muscle fiber diameter (HP:0003557)1.72244354
140Annular pancreas (HP:0001734)1.71395931
141Fat malabsorption (HP:0002630)1.69764954
142Short phalanx of the thumb (HP:0009660)1.69251450
143Bronchomalacia (HP:0002780)1.68453886
144Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67206368
145Aplasia of the musculature (HP:0100854)1.66903323
146Absence seizures (HP:0002121)1.64858780
147Insidious onset (HP:0003587)1.64587883
148Termporal pattern (HP:0011008)1.64587883
149Hypoplastic nipples (HP:0002557)1.64026355
150Flat acetabular roof (HP:0003180)1.63933910
151Poor eye contact (HP:0000817)1.62289810
152Postural instability (HP:0002172)1.60937820
153Ankle clonus (HP:0011448)1.60224257
154Palmoplantar hyperkeratosis (HP:0000972)1.60040025
155Generalized tonic-clonic seizures (HP:0002069)1.59211506
156Palmar hyperkeratosis (HP:0010765)1.58843201
157Sudden death (HP:0001699)1.58498658
158Myopathic facies (HP:0002058)1.57723056
159Alopecia of scalp (HP:0002293)1.57016792
160Impaired vibratory sensation (HP:0002495)1.57000537
161Pseudobulbar signs (HP:0002200)1.56800869
162Syncope (HP:0001279)1.56532176
163Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56381236
164Vertebral hypoplasia (HP:0008417)1.56381236
165Ventricular arrhythmia (HP:0004308)1.56005695
166Round ear (HP:0100830)1.54511855
167Xanthomatosis (HP:0000991)1.54407900
168Hand muscle atrophy (HP:0009130)1.54237812
169Ulnar claw (HP:0001178)1.54002777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.14855134
2OBSCN3.62215266
3EPHA43.39822985
4EPHA23.08857942
5AKT32.95579137
6DAPK22.84646533
7KSR22.38027494
8NEK12.23294289
9MAP3K22.13595592
10NTRK32.05069805
11RIPK11.99964115
12LATS21.98146993
13MAP3K41.92246366
14MST1R1.86118244
15TTN1.84207142
16CDK121.80665041
17MAP2K41.80220535
18PAK61.75046435
19LMTK21.71379444
20FER1.58923668
21TYRO31.57676862
22FRK1.56556871
23LATS11.48771322
24MAPKAPK31.48613594
25TAOK11.48389465
26DDR21.45706440
27MAP3K121.44774866
28NEK61.40163138
29TRIB31.39657300
30MST41.39149465
31DAPK11.38996086
32MET1.38539655
33SGK2231.34778807
34SGK4941.34778807
35NTRK11.30300953
36CAMK2B1.28332542
37STK381.28294937
38PRKD31.27802253
39MINK11.25236733
40CAMK2G1.25057723
41ARAF1.21336964
42MAPK121.20785654
43KSR11.19867174
44STK391.18096063
45CAMK11.15583012
46PNCK1.11489277
47DMPK1.09077832
48NME11.08618733
49GRK51.08473010
50SGK21.07501205
51FGFR21.02030674
52MAP3K71.00727635
53MARK20.99754091
54MARK10.96818443
55CAMK1G0.96202004
56PAK30.96178773
57CAMK2D0.91118893
58PRPF4B0.89700333
59CAMKK10.88819023
60CAMK1D0.88732838
61ALK0.87461482
62ICK0.87369208
63PDPK10.86314274
64CDK50.85470284
65BMX0.84140482
66RPS6KB20.83448351
67ERBB40.83394518
68BCR0.82563901
69PRKCI0.81865650
70MAP3K130.80920137
71PRKG20.80342827
72NTRK20.76809755
73MAP2K10.76432677
74PTK20.76312416
75* MAPK100.74720828
76TTK0.73819698
77PHKG20.69837140
78PHKG10.69837140
79CAMK40.69045342
80STK110.68904224
81RIPK40.67687756
82MAP3K10.67282056
83RET0.67119048
84MATK0.65182264
85PDK30.61988061
86PDK40.61988061
87PRKCH0.61717519
88CASK0.61660360
89PDK10.60557535
90OXSR10.60482552
91PRKAA10.60329197
92STK38L0.60326461
93WNK30.59229382
94GRK60.58191048
95CSNK1E0.58062276
96MAP3K110.57742909
97PIK3CA0.55656703
98MUSK0.55528543
99SGK30.55502023
100EPHB20.55117194
101PRKAA20.55064114
102CDK150.55014342
103PBK0.54983934
104FGFR10.54654154
105MAP2K70.54580220
106MAP3K60.53746044
107SCYL20.53603224
108CDK140.53330000
109CDK180.52985744
110FGFR40.52632635
111CDK11A0.51822419
112MTOR0.51680623
113CDC42BPA0.50975635
114LIMK10.50830141
115ROCK20.50165143
116PDGFRA0.50070918
117CDK60.50014521
118CSNK1D0.49783891
119WNK10.49607331
120DAPK30.48184479
121BRD40.47523526
122RPS6KB10.47381097
123CDK190.47327861
124PLK20.46781464
125PDK20.45986773
126MAP2K60.45743711
127SGK10.44685360
128ROCK10.44218688
129ERBB20.44091168
130WNK40.44040999
131MAPK150.43671108
132EEF2K0.42803273
133RAF10.42740224
134DYRK1A0.42669172
135PINK10.42337509
136* RPS6KA30.40932889
137UHMK10.39315755
138AKT20.39084718
139PRKCG0.38953321
140CAMK2A0.38663905

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.49787545
2Fat digestion and absorption_Homo sapiens_hsa049752.34606959
3Arginine biosynthesis_Homo sapiens_hsa002202.29443465
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.25450136
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01812770
6Bile secretion_Homo sapiens_hsa049762.00264990
7Renin-angiotensin system_Homo sapiens_hsa046141.95605840
8Synaptic vesicle cycle_Homo sapiens_hsa047211.83969937
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.83022265
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78448467
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76726512
12Mineral absorption_Homo sapiens_hsa049781.75422741
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73845887
14Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69919716
15Arginine and proline metabolism_Homo sapiens_hsa003301.68950757
16Long-term potentiation_Homo sapiens_hsa047201.49001495
17Vitamin B6 metabolism_Homo sapiens_hsa007501.42400936
18Gastric acid secretion_Homo sapiens_hsa049711.41011664
19Amphetamine addiction_Homo sapiens_hsa050311.39505093
20Salivary secretion_Homo sapiens_hsa049701.39281188
21Tight junction_Homo sapiens_hsa045301.36437557
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34885257
23Cardiac muscle contraction_Homo sapiens_hsa042601.33165403
24Olfactory transduction_Homo sapiens_hsa047401.31817153
25Starch and sucrose metabolism_Homo sapiens_hsa005001.28195082
26Insulin secretion_Homo sapiens_hsa049111.27629067
27Galactose metabolism_Homo sapiens_hsa000521.26050971
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.25674000
29GnRH signaling pathway_Homo sapiens_hsa049121.24213023
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22198202
31Nicotine addiction_Homo sapiens_hsa050331.20836786
32Circadian rhythm_Homo sapiens_hsa047101.19656595
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18531463
34Caffeine metabolism_Homo sapiens_hsa002321.18236451
35Vitamin digestion and absorption_Homo sapiens_hsa049771.16611302
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14886375
37beta-Alanine metabolism_Homo sapiens_hsa004101.14792009
38Circadian entrainment_Homo sapiens_hsa047131.12527772
39Sulfur metabolism_Homo sapiens_hsa009201.09606292
40Protein digestion and absorption_Homo sapiens_hsa049741.09572912
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07329861
42Bladder cancer_Homo sapiens_hsa052191.06741626
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06388243
44Dopaminergic synapse_Homo sapiens_hsa047281.03292250
45Glutamatergic synapse_Homo sapiens_hsa047241.02540709
46GABAergic synapse_Homo sapiens_hsa047271.01141602
47Tryptophan metabolism_Homo sapiens_hsa003801.00478535
48Gap junction_Homo sapiens_hsa045401.00104548
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99550970
50Renin secretion_Homo sapiens_hsa049240.96065783
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95882014
52Biosynthesis of amino acids_Homo sapiens_hsa012300.95740670
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94999607
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94840013
55Oxytocin signaling pathway_Homo sapiens_hsa049210.94117399
56Fructose and mannose metabolism_Homo sapiens_hsa000510.92912007
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91358714
58Hippo signaling pathway_Homo sapiens_hsa043900.90531829
59Insulin signaling pathway_Homo sapiens_hsa049100.89081886
60Histidine metabolism_Homo sapiens_hsa003400.86493193
61Adherens junction_Homo sapiens_hsa045200.86300716
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85841740
63Melanogenesis_Homo sapiens_hsa049160.83047780
64ErbB signaling pathway_Homo sapiens_hsa040120.82680551
65Thyroid hormone synthesis_Homo sapiens_hsa049180.81457328
66Long-term depression_Homo sapiens_hsa047300.79885281
67AMPK signaling pathway_Homo sapiens_hsa041520.78649787
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78495952
69Cholinergic synapse_Homo sapiens_hsa047250.77970567
70Estrogen signaling pathway_Homo sapiens_hsa049150.77838536
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77048425
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77007611
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75270756
74Type II diabetes mellitus_Homo sapiens_hsa049300.75156051
75Dorso-ventral axis formation_Homo sapiens_hsa043200.75038502
76Cocaine addiction_Homo sapiens_hsa050300.75001686
77Folate biosynthesis_Homo sapiens_hsa007900.74560350
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74147156
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70738419
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69681519
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69161756
82Fatty acid metabolism_Homo sapiens_hsa012120.68759968
83Calcium signaling pathway_Homo sapiens_hsa040200.67736955
84Morphine addiction_Homo sapiens_hsa050320.66646558
85Fatty acid biosynthesis_Homo sapiens_hsa000610.66203698
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66034777
87Glucagon signaling pathway_Homo sapiens_hsa049220.64471188
88Glioma_Homo sapiens_hsa052140.63911558
89PPAR signaling pathway_Homo sapiens_hsa033200.63773709
90Carbon metabolism_Homo sapiens_hsa012000.63538816
91Pancreatic secretion_Homo sapiens_hsa049720.63227758
92Glycerolipid metabolism_Homo sapiens_hsa005610.62453193
93mTOR signaling pathway_Homo sapiens_hsa041500.61773327
94Thyroid cancer_Homo sapiens_hsa052160.61380138
95Taste transduction_Homo sapiens_hsa047420.60952380
96Phenylalanine metabolism_Homo sapiens_hsa003600.60448507
97Butanoate metabolism_Homo sapiens_hsa006500.59332641
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58807016
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.57439104
100Chemical carcinogenesis_Homo sapiens_hsa052040.56894848
101Tyrosine metabolism_Homo sapiens_hsa003500.56380111
102Inositol phosphate metabolism_Homo sapiens_hsa005620.55537024
103Axon guidance_Homo sapiens_hsa043600.55168161
104Prion diseases_Homo sapiens_hsa050200.54995576
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54985042
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54834875
107Fatty acid degradation_Homo sapiens_hsa000710.54410693
108Endometrial cancer_Homo sapiens_hsa052130.53854623
109Serotonergic synapse_Homo sapiens_hsa047260.53655165
110Pyruvate metabolism_Homo sapiens_hsa006200.53525941
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53413012
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52495461
113Oocyte meiosis_Homo sapiens_hsa041140.51175358
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50330962
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.50297576
116Choline metabolism in cancer_Homo sapiens_hsa052310.49718317
117Dilated cardiomyopathy_Homo sapiens_hsa054140.49665040
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.49357555
119Glutathione metabolism_Homo sapiens_hsa004800.48103191
120cAMP signaling pathway_Homo sapiens_hsa040240.47727449
121Insulin resistance_Homo sapiens_hsa049310.47360959
122ABC transporters_Homo sapiens_hsa020100.46842499
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44992225
124Ovarian steroidogenesis_Homo sapiens_hsa049130.43437832
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39102361
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38368531

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