COBLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)5.91539610
2estrogen biosynthetic process (GO:0006703)5.44634634
3lysine metabolic process (GO:0006553)4.91965242
4lysine catabolic process (GO:0006554)4.91965242
5L-phenylalanine catabolic process (GO:0006559)4.89838370
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.89838370
7L-phenylalanine metabolic process (GO:0006558)4.66293813
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.66293813
9aromatic amino acid family catabolic process (GO:0009074)4.34126259
10androgen biosynthetic process (GO:0006702)4.24856425
11glucocorticoid metabolic process (GO:0008211)4.20347617
12drug transmembrane transport (GO:0006855)4.15330464
13glyoxylate metabolic process (GO:0046487)4.14300961
14valine metabolic process (GO:0006573)4.10976742
15alpha-linolenic acid metabolic process (GO:0036109)4.09751109
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07674817
17cysteine metabolic process (GO:0006534)3.93583007
182-oxoglutarate metabolic process (GO:0006103)3.88956027
19fatty acid beta-oxidation (GO:0006635)3.87231979
20kynurenine metabolic process (GO:0070189)3.87180153
21negative regulation of protein activation cascade (GO:2000258)3.84443942
22tryptophan catabolic process (GO:0006569)3.82857880
23indole-containing compound catabolic process (GO:0042436)3.82857880
24indolalkylamine catabolic process (GO:0046218)3.82857880
25short-chain fatty acid metabolic process (GO:0046459)3.70728143
26tryptophan metabolic process (GO:0006568)3.69354284
27fatty acid oxidation (GO:0019395)3.68634667
28response to follicle-stimulating hormone (GO:0032354)3.67461267
29sulfur amino acid catabolic process (GO:0000098)3.63804653
30negative regulation of complement activation (GO:0045916)3.63043615
31amino-acid betaine metabolic process (GO:0006577)3.60963964
32lipid oxidation (GO:0034440)3.59667254
33bile acid biosynthetic process (GO:0006699)3.58954132
34urate metabolic process (GO:0046415)3.55533598
35homocysteine metabolic process (GO:0050667)3.54827824
36aspartate family amino acid catabolic process (GO:0009068)3.49221555
37regulation of cholesterol homeostasis (GO:2000188)3.47671777
38androgen metabolic process (GO:0008209)3.44232540
39endocrine hormone secretion (GO:0060986)3.42555811
404-hydroxyproline metabolic process (GO:0019471)3.41296743
41desmosome organization (GO:0002934)3.41205988
42branched-chain amino acid metabolic process (GO:0009081)3.40786456
43protein carboxylation (GO:0018214)3.39048841
44peptidyl-glutamic acid carboxylation (GO:0017187)3.39048841
45fatty acid catabolic process (GO:0009062)3.38510066
46tricarboxylic acid metabolic process (GO:0072350)3.31096466
47estrogen metabolic process (GO:0008210)3.28934582
48branched-chain amino acid catabolic process (GO:0009083)3.26070118
49response to mercury ion (GO:0046689)3.23558855
50benzene-containing compound metabolic process (GO:0042537)3.22185689
51triglyceride homeostasis (GO:0070328)3.21427899
52acylglycerol homeostasis (GO:0055090)3.21427899
53cellular ketone body metabolic process (GO:0046950)3.21422668
54acetyl-CoA metabolic process (GO:0006084)3.20041529
55fatty acid transmembrane transport (GO:1902001)3.18864981
56carnitine metabolic process (GO:0009437)3.18612232
57monocarboxylic acid catabolic process (GO:0072329)3.18255159
58positive regulation of fatty acid beta-oxidation (GO:0032000)3.17979041
59drug transport (GO:0015893)3.17599057
60negative regulation of fibrinolysis (GO:0051918)3.15337859
61high-density lipoprotein particle remodeling (GO:0034375)3.14814256
62carnitine shuttle (GO:0006853)3.14024965
63cellular modified amino acid catabolic process (GO:0042219)3.12043572
64alpha-amino acid catabolic process (GO:1901606)3.08207540
65bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04275092
66bile acid metabolic process (GO:0008206)3.03791218
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.03381868
68regulation of triglyceride catabolic process (GO:0010896)3.03379112
69aromatic amino acid family metabolic process (GO:0009072)3.02510883
70serine family amino acid catabolic process (GO:0009071)3.00848618
71cellular glucuronidation (GO:0052695)2.99924439
72quaternary ammonium group transport (GO:0015697)2.99893763
73ethanol oxidation (GO:0006069)2.99561048
74biotin metabolic process (GO:0006768)2.99164593
75cellular amino acid catabolic process (GO:0009063)2.99049349
76regulation of fibrinolysis (GO:0051917)2.98621078
77transcytosis (GO:0045056)2.97978225
78COPII vesicle coating (GO:0048208)2.97666173
79drug catabolic process (GO:0042737)2.97628539
80amino-acid betaine transport (GO:0015838)2.96699213
81carnitine transport (GO:0015879)2.96699213
82intestinal cholesterol absorption (GO:0030299)2.95656130
83excretion (GO:0007588)2.94491629
84COPI coating of Golgi vesicle (GO:0048205)2.92711355
85Golgi transport vesicle coating (GO:0048200)2.92711355
86regulation of protein activation cascade (GO:2000257)2.91772319
87tyrosine metabolic process (GO:0006570)2.91609515
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90311587
89positive regulation of fatty acid oxidation (GO:0046321)2.89170007
90iron ion import (GO:0097286)2.87949840
91organic acid catabolic process (GO:0016054)2.86656643
92carboxylic acid catabolic process (GO:0046395)2.86656643
93regulation of sequestering of triglyceride (GO:0010889)2.85715417
94glutamate metabolic process (GO:0006536)2.83664136
95reverse cholesterol transport (GO:0043691)2.82642671
96metanephric tubule development (GO:0072170)2.82411094
97metanephric nephron tubule development (GO:0072234)2.82411094
98cellular response to growth hormone stimulus (GO:0071378)2.81359836
99complement activation, alternative pathway (GO:0006957)2.81180157
100regulation of complement activation (GO:0030449)2.78837557
101polyol transport (GO:0015791)2.76165273
102C21-steroid hormone biosynthetic process (GO:0006700)2.75770491
103ketone body metabolic process (GO:1902224)2.75320447
104regulation of fatty acid beta-oxidation (GO:0031998)2.74165171
105phospholipid homeostasis (GO:0055091)2.74140874
106regulation of apoptotic cell clearance (GO:2000425)2.74034756
107plasma lipoprotein particle clearance (GO:0034381)2.73864568
108low-density lipoprotein particle clearance (GO:0034383)2.73615908
109carnitine transmembrane transport (GO:1902603)2.72240617
110urea cycle (GO:0000050)2.72179708
111urea metabolic process (GO:0019627)2.72179708
112metanephric nephron epithelium development (GO:0072243)2.71556950
113blood coagulation, intrinsic pathway (GO:0007597)2.71501280
114epoxygenase P450 pathway (GO:0019373)2.71389516
115lymphangiogenesis (GO:0001946)2.70820708
116protein retention in ER lumen (GO:0006621)2.70582517
117complement activation, classical pathway (GO:0006958)2.68613867
118regulation of fatty acid oxidation (GO:0046320)2.67246173
119ovulation from ovarian follicle (GO:0001542)2.66325603
120glucuronate metabolic process (GO:0019585)2.66032067
121uronic acid metabolic process (GO:0006063)2.66032067
122regulation of plasminogen activation (GO:0010755)2.65329358
123endocardial cushion development (GO:0003197)2.65066767
124anterior/posterior axis specification, embryo (GO:0008595)2.64949091
125indolalkylamine metabolic process (GO:0006586)2.64742428
126coenzyme catabolic process (GO:0009109)2.63131434
127positive regulation of glycolytic process (GO:0045821)2.62852307
128protein activation cascade (GO:0072376)2.61907916
129embryonic retina morphogenesis in camera-type eye (GO:0060059)2.61712002
130ethanol metabolic process (GO:0006067)2.59356129
131hormone biosynthetic process (GO:0042446)2.57931772
132positive regulation of hormone metabolic process (GO:0032352)2.57450569
133omega-hydroxylase P450 pathway (GO:0097267)2.56068255
134negative regulation of humoral immune response (GO:0002921)2.55573795
135smooth muscle tissue development (GO:0048745)2.51463604
136protein-lipid complex remodeling (GO:0034368)2.50304831
137macromolecular complex remodeling (GO:0034367)2.50304831
138plasma lipoprotein particle remodeling (GO:0034369)2.50304831
139regulation of phospholipase A2 activity (GO:0032429)2.49383420
140C21-steroid hormone metabolic process (GO:0008207)2.47472374
141progesterone metabolic process (GO:0042448)2.47028237
142cholesterol efflux (GO:0033344)2.46244833
143metanephric epithelium development (GO:0072207)2.45879940
144flavonoid metabolic process (GO:0009812)2.45271681
145glomerular basement membrane development (GO:0032836)2.44417420
146complement activation (GO:0006956)2.44049851
147regulation of transforming growth factor beta2 production (GO:0032909)2.42257033
148interkinetic nuclear migration (GO:0022027)2.41883129
149import into cell (GO:0098657)2.41627133
150prostate gland growth (GO:0060736)2.38998764
151negative regulation of cholesterol transport (GO:0032375)2.38787302
152negative regulation of sterol transport (GO:0032372)2.38787302
153negative regulation of lipase activity (GO:0060192)2.37740169
154aminoglycoside antibiotic metabolic process (GO:0030647)2.36463466
155basement membrane organization (GO:0071711)2.36453774
156regulation of humoral immune response (GO:0002920)2.36402504
157renal absorption (GO:0070293)2.36293559
158response to water (GO:0009415)2.33815802
159female pregnancy (GO:0007565)2.33248523
160toxin metabolic process (GO:0009404)2.32312990
161collecting duct development (GO:0072044)2.30602436
162negative regulation of fatty acid transport (GO:2000192)2.29775983
163lipoprotein metabolic process (GO:0042157)2.29435481
164regulation of steroid hormone biosynthetic process (GO:0090030)2.28956517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.85522878
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.13990404
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.57508817
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.48810483
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.48658138
6* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.11992393
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.07194426
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.03466642
9CLOCK_20551151_ChIP-Seq_293T_Human2.96324438
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.77558220
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.70999420
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.48389309
13* TRIM28_21343339_ChIP-Seq_HEK293_Human2.47781054
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.42319291
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24153664
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.18235693
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.11837134
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08190085
19* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.07589033
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.97752641
21* EP300_21415370_ChIP-Seq_HL-1_Mouse1.84108890
22ARNT_22903824_ChIP-Seq_MCF-7_Human1.83633117
23* FOXA2_19822575_ChIP-Seq_HepG2_Human1.80520137
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.74733413
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.72692406
26* TBX20_22328084_ChIP-Seq_HEART_Mouse1.68449327
27* TBX20_22080862_ChIP-Seq_HEART_Mouse1.68449327
28* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64589980
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63124378
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61929014
31GBX2_23144817_ChIP-Seq_PC3_Human1.61198178
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59883370
33GATA1_22025678_ChIP-Seq_K562_Human1.56833384
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55956776
35* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54679621
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54193638
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51528590
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51364764
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49669373
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.47896536
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.47105278
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45778046
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45131721
44* GATA4_25053715_ChIP-Seq_YYC3_Human1.43286960
45CJUN_26792858_Chip-Seq_BT549_Human1.41620755
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41323913
47* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41204818
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38986807
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38986807
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38473733
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38434218
52* TP53_18474530_ChIP-ChIP_U2OS_Human1.37725549
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37047951
54SMAD4_21799915_ChIP-Seq_A2780_Human1.33114133
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32591711
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32530167
57* SOX2_20726797_ChIP-Seq_SW620_Human1.31452462
58* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29886136
59ZNF263_19887448_ChIP-Seq_K562_Human1.29112999
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28965008
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26945527
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26445848
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25828308
64CDX2_22108803_ChIP-Seq_LS180_Human1.24364475
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24096687
66* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22669410
67TP53_16413492_ChIP-PET_HCT116_Human1.22505703
68TAF15_26573619_Chip-Seq_HEK293_Human1.21619663
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20347893
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19541052
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18709766
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17413378
73* SMAD3_21741376_ChIP-Seq_HESCs_Human1.17253541
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16557397
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13267583
76AR_25329375_ChIP-Seq_VCAP_Human1.11944532
77* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11914950
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.10441436
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10195616
80STAT3_23295773_ChIP-Seq_U87_Human1.09781637
81AR_21572438_ChIP-Seq_LNCaP_Human1.08975832
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08914909
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08099136
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07408801
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.07023575
86P300_19829295_ChIP-Seq_ESCs_Human1.06914975
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06891739
88* GATA3_24758297_ChIP-Seq_MCF-7_Human1.06722917
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05272214
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05145941
91* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05124734
92* TCF4_23295773_ChIP-Seq_U87_Human1.03874754
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02397847
94* FOXA1_25552417_ChIP-Seq_VCAP_Human1.02245267
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02190523
96* GATA6_25053715_ChIP-Seq_YYC3_Human1.02189614
97* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01979105
98NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01411372
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01221480
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.00694810
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00215203
102PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99288426
103FLI1_27457419_Chip-Seq_LIVER_Mouse0.98690923
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.98443144
105TCF4_22108803_ChIP-Seq_LS180_Human0.98032467
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97256165
107* TP63_23658742_ChIP-Seq_EP156T_Human0.97082366
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96633294
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96608510
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95192036
111* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94597194
112* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94597194
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90652137
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90623407
115GATA1_19941826_ChIP-Seq_K562_Human0.89482827
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89070549
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.88696484
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87355765
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87270987
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87173829
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85644867
122BCAT_22108803_ChIP-Seq_LS180_Human0.85090212
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83922876
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82944754
125* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82641819
126JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81383356
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80988886
128RXR_22108803_ChIP-Seq_LS180_Human0.80357866
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79773458
130* RUNX1_27514584_Chip-Seq_MCF-7_Human0.79731171
131GATA2_19941826_ChIP-Seq_K562_Human0.79571551
132AHR_22903824_ChIP-Seq_MCF-7_Human0.79011344
133* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78943468
134* ISL1_27105846_Chip-Seq_CPCs_Mouse0.78606163
135RACK7_27058665_Chip-Seq_MCF-7_Human0.78109800
136* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75050146
137BRD4_25478319_ChIP-Seq_HGPS_Human0.74948924
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74626368
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74550614
140ATF3_27146783_Chip-Seq_COLON_Human0.74515394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.31991468
2MP0005360_urolithiasis4.94977478
3MP0005085_abnormal_gallbladder_physiolo3.80444249
4MP0005365_abnormal_bile_salt3.76462289
5MP0003195_calcinosis3.33668550
6MP0008875_abnormal_xenobiotic_pharmacok3.15200540
7MP0003252_abnormal_bile_duct3.03092090
8MP0004043_abnormal_pH_regulation2.41860979
9MP0005332_abnormal_amino_acid2.34255197
10MP0002837_dystrophic_cardiac_calcinosis2.31982666
11MP0003941_abnormal_skin_development2.21010514
12MP0010329_abnormal_lipoprotein_level2.10397500
13MP0003300_gastrointestinal_ulcer1.99980544
14MP0005670_abnormal_white_adipose1.93732889
15MP0009643_abnormal_urine_homeostasis1.90479204
16MP0004084_abnormal_cardiac_muscle1.90262791
17MP0010368_abnormal_lymphatic_system1.89229263
18MP0003705_abnormal_hypodermis_morpholog1.87609142
19MP0001666_abnormal_nutrient_absorption1.84608561
20MP0009384_cardiac_valve_regurgitation1.84580684
21MP0002138_abnormal_hepatobiliary_system1.79979322
22MP0005503_abnormal_tendon_morphology1.78479599
23MP0009697_abnormal_copulation1.76724649
24MP0003806_abnormal_nucleotide_metabolis1.74644044
25MP0004019_abnormal_vitamin_homeostasis1.70073583
26MP0003950_abnormal_plasma_membrane1.68892326
27MP0004272_abnormal_basement_membrane1.55506556
28MP0002118_abnormal_lipid_homeostasis1.55288661
29MP0001765_abnormal_ion_homeostasis1.54686054
30MP0001756_abnormal_urination1.52961443
31MP0005666_abnormal_adipose_tissue1.49465068
32MP0003191_abnormal_cellular_cholesterol1.48193918
33MP0005319_abnormal_enzyme/_coenzyme1.47848994
34MP0005083_abnormal_biliary_tract1.44493259
35MP0000609_abnormal_liver_physiology1.41995580
36MP0005379_endocrine/exocrine_gland_phen1.40276355
37MP0002877_abnormal_melanocyte_morpholog1.40087667
38MP0004130_abnormal_muscle_cell1.38693977
39MP0010678_abnormal_skin_adnexa1.36691841
40MP0009780_abnormal_chondrocyte_physiolo1.36622296
41MP0005330_cardiomyopathy1.34856628
42MP0002909_abnormal_adrenal_gland1.34749090
43MP0001879_abnormal_lymphatic_vessel1.32878459
44MP0010234_abnormal_vibrissa_follicle1.32811639
45MP0003959_abnormal_lean_body1.27746269
46MP0004036_abnormal_muscle_relaxation1.26908890
47MP0005636_abnormal_mineral_homeostasis1.26176943
48MP0005409_darkened_coat_color1.26062933
49MP0002009_preneoplasia1.25093584
50MP0000383_abnormal_hair_follicle1.24699666
51MP0005220_abnormal_exocrine_pancreas1.24494504
52MP0008004_abnormal_stomach_pH1.22112245
53MP0003011_delayed_dark_adaptation1.21600245
54MP0009115_abnormal_fat_cell1.21012552
55MP0002896_abnormal_bone_mineralization1.19637281
56MP0002108_abnormal_muscle_morphology1.14507602
57MP0003868_abnormal_feces_composition1.14141002
58MP0000230_abnormal_systemic_arterial1.14137833
59MP0006138_congestive_heart_failure1.14110189
60MP0010386_abnormal_urinary_bladder1.14094837
61MP0005375_adipose_tissue_phenotype1.12516487
62MP0002136_abnormal_kidney_physiology1.07567693
63MP0009840_abnormal_foam_cell1.06328156
64MP0000538_abnormal_urinary_bladder1.05395847
65MP0002796_impaired_skin_barrier1.05076360
66MP0002972_abnormal_cardiac_muscle1.04374876
67MP0002168_other_aberrant_phenotype1.03870752
68MP0010630_abnormal_cardiac_muscle1.03018231
69MP0004264_abnormal_extraembryonic_tissu1.01417195
70MP0008775_abnormal_heart_ventricle1.01380921
71MP0005084_abnormal_gallbladder_morpholo1.01282349
72MP0005584_abnormal_enzyme/coenzyme_acti1.00495162
73MP0002928_abnormal_bile_duct1.00385802
74MP0004215_abnormal_myocardial_fiber1.00058017
75MP0003890_abnormal_embryonic-extraembry1.00030800
76MP0004185_abnormal_adipocyte_glucose0.98417168
77MP0002876_abnormal_thyroid_physiology0.97487130
78MP0008961_abnormal_basal_metabolism0.96001079
79MP0003566_abnormal_cell_adhesion0.95006501
80MP0008438_abnormal_cutaneous_collagen0.94781263
81MP0003279_aneurysm0.94651283
82MP0002078_abnormal_glucose_homeostasis0.94519460
83MP0005275_abnormal_skin_tensile0.94040777
84MP0001544_abnormal_cardiovascular_syste0.91961630
85MP0005385_cardiovascular_system_phenoty0.91961630
86MP0001270_distended_abdomen0.91802516
87MP0000013_abnormal_adipose_tissue0.91239706
88MP0004087_abnormal_muscle_fiber0.89816304
89MP0004484_altered_response_of0.89696269
90MP0010352_gastrointestinal_tract_polyps0.89679085
91MP0006054_spinal_hemorrhage0.89489899
92MP0005164_abnormal_response_to0.89023655
93MP0003186_abnormal_redox_activity0.88274271
94MP0000003_abnormal_adipose_tissue0.88221578
95MP0001944_abnormal_pancreas_morphology0.87645861
96MP0003045_fibrosis0.87478152
97MP0003646_muscle_fatigue0.87194731
98MP0005620_abnormal_muscle_contractility0.85716737
99MP0000767_abnormal_smooth_muscle0.84996553
100MP0000598_abnormal_liver_morphology0.82768525
101MP0000751_myopathy0.82636429
102MP0005451_abnormal_body_composition0.81440008
103MP0005647_abnormal_sex_gland0.80811811
104MP0005595_abnormal_vascular_smooth0.80431377
105MP0003953_abnormal_hormone_level0.80430359
106MP0003283_abnormal_digestive_organ0.79037685
107MP0005395_other_phenotype0.77856666
108MP0005408_hypopigmentation0.77722839
109MP0000163_abnormal_cartilage_morphology0.77702661
110MP0000762_abnormal_tongue_morphology0.77491023
111MP0001661_extended_life_span0.77376536
112MP0002971_abnormal_brown_adipose0.77375162
113MP0002933_joint_inflammation0.75412916
114MP0002166_altered_tumor_susceptibility0.75128493
115MP0000749_muscle_degeneration0.74318725
116MP0000534_abnormal_ureter_morphology0.73981259
117MP0000639_abnormal_adrenal_gland0.73599662
118MP0005187_abnormal_penis_morphology0.73153699
119MP0004782_abnormal_surfactant_physiolog0.72906928
120MP0002128_abnormal_blood_circulation0.72118370
121MP0002060_abnormal_skin_morphology0.71026992
122MP0002295_abnormal_pulmonary_circulatio0.68716051
123MP0001958_emphysema0.67522511
124MP0005023_abnormal_wound_healing0.67423644
125MP0004085_abnormal_heartbeat0.67172617
126MP0005623_abnormal_meninges_morphology0.66068790
127MP0005165_increased_susceptibility_to0.65678374
128MP0001915_intracranial_hemorrhage0.65293372
129MP0005334_abnormal_fat_pad0.65091172
130MP0005448_abnormal_energy_balance0.64734280
131MP0003091_abnormal_cell_migration0.64502710
132MP0002269_muscular_atrophy0.64496588
133MP0009642_abnormal_blood_homeostasis0.64224893
134MP0001764_abnormal_homeostasis0.63758871
135MP0006276_abnormal_autonomic_nervous0.62894643

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.87220164
2Intrahepatic cholestasis (HP:0001406)4.10411608
3Ketoacidosis (HP:0001993)4.01039248
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.98319651
5Deep venous thrombosis (HP:0002625)3.90126538
6Ketosis (HP:0001946)3.85001894
7Xanthomatosis (HP:0000991)3.68329792
8Hyperglycinuria (HP:0003108)3.60354652
9Decreased circulating renin level (HP:0003351)3.59874735
10Abnormality of the axillary hair (HP:0100134)3.47020746
11Abnormality of secondary sexual hair (HP:0009888)3.47020746
12Abnormality of complement system (HP:0005339)3.42442669
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.41631888
14Abnormality of fatty-acid metabolism (HP:0004359)3.38767550
15Gout (HP:0001997)3.32717145
16Abnormality of glycine metabolism (HP:0010895)3.23190337
17Abnormality of serine family amino acid metabolism (HP:0010894)3.23190337
18Hypoplastic ischia (HP:0003175)3.21601758
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.20752962
20Hyperinsulinemic hypoglycemia (HP:0000825)3.20034546
21Hypoglycemic seizures (HP:0002173)3.18044203
22Hyperammonemia (HP:0001987)3.16322341
23Generalized aminoaciduria (HP:0002909)3.15839614
24Right ventricular cardiomyopathy (HP:0011663)3.13375860
25Increased circulating renin level (HP:0000848)3.11489446
26Epiphyseal dysplasia (HP:0002656)3.07716968
27Aortic aneurysm (HP:0004942)3.02890300
28Abnormality of the ischium (HP:0003174)3.01767479
29Potter facies (HP:0002009)3.00674962
30Facial shape deformation (HP:0011334)3.00674962
31Abnormal tarsal ossification (HP:0008369)2.99974092
32Mitral stenosis (HP:0001718)2.90472418
33Glomerulonephritis (HP:0000099)2.90282607
34Abnormality of purine metabolism (HP:0004352)2.88519414
35Abnormality of the common coagulation pathway (HP:0010990)2.86262958
36Abnormality of magnesium homeostasis (HP:0004921)2.82069395
37Hypoalphalipoproteinemia (HP:0003233)2.78290958
38Proximal tubulopathy (HP:0000114)2.76650201
39Prolonged partial thromboplastin time (HP:0003645)2.72744188
40Abnormality of the intrinsic pathway (HP:0010989)2.71340493
41Polydipsia (HP:0001959)2.70717729
42Abnormal drinking behavior (HP:0030082)2.70717729
43Hyperglycinemia (HP:0002154)2.70339548
44Protuberant abdomen (HP:0001538)2.68440820
45Adrenal overactivity (HP:0002717)2.66427732
46Hydroxyprolinuria (HP:0003080)2.65143740
47Abnormality of proline metabolism (HP:0010907)2.65143740
48Hypokalemic alkalosis (HP:0001949)2.64055674
49Hyperglycemia (HP:0003074)2.60604731
50Renal salt wasting (HP:0000127)2.60483178
51Abnormality of chloride homeostasis (HP:0011422)2.58758226
52Hyperlipoproteinemia (HP:0010980)2.57047284
53Abnormality of aspartate family amino acid metabolism (HP:0010899)2.55173957
54Flat acetabular roof (HP:0003180)2.54048065
55Increased purine levels (HP:0004368)2.53466618
56Hyperuricemia (HP:0002149)2.53466618
57Symptomatic seizures (HP:0011145)2.49215921
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48407663
59Dicarboxylic aciduria (HP:0003215)2.48407663
60Epidermoid cyst (HP:0200040)2.47714820
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.46730717
62Metaphyseal cupping (HP:0003021)2.44017516
63Abnormal foot bone ossification (HP:0010675)2.43016169
64Cupped ribs (HP:0000887)2.42918663
65Abnormality of carpal bone ossification (HP:0006257)2.42423293
66Fair hair (HP:0002286)2.40292162
67Hyperactive renin-angiotensin system (HP:0000841)2.40223320
68Fat malabsorption (HP:0002630)2.39658389
69Abnormality of renin-angiotensin system (HP:0000847)2.38265475
70Joint hemorrhage (HP:0005261)2.35904621
71Nephritis (HP:0000123)2.33739862
72Hypolipoproteinemia (HP:0010981)2.33019106
73Complement deficiency (HP:0004431)2.32500918
74Lymphangioma (HP:0100764)2.30087379
75Metaphyseal dysplasia (HP:0100255)2.28715755
76Ventricular tachycardia (HP:0004756)2.26925439
77Aortic dissection (HP:0002647)2.25803112
78Vascular calcification (HP:0004934)2.25149899
79Hyperaldosteronism (HP:0000859)2.24268744
80Metabolic alkalosis (HP:0200114)2.22508505
81Myoglobinuria (HP:0002913)2.22437826
82Abnormal cartilage morphology (HP:0002763)2.21208942
83Spontaneous abortion (HP:0005268)2.20195198
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.20058994
85Metabolic acidosis (HP:0001942)2.19512391
86Abnormality of nucleobase metabolism (HP:0010932)2.19438809
87Tetany (HP:0001281)2.19218351
88Muscle fiber splitting (HP:0003555)2.18402942
89Lip pit (HP:0100267)2.17397323
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17101204
91Vitreoretinal degeneration (HP:0000655)2.15734540
92Protrusio acetabuli (HP:0003179)2.13453020
93Myocardial infarction (HP:0001658)2.12618657
94Cardiovascular calcification (HP:0011915)2.12344934
95Abnormal hand bone ossification (HP:0010660)2.10455788
96Abnormal urine output (HP:0012590)2.09206151
97Late onset (HP:0003584)2.09052189
98Hyporeflexia of lower limbs (HP:0002600)2.07980154
99Hypobetalipoproteinemia (HP:0003563)2.07508064
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07145077
101Alkalosis (HP:0001948)2.06527174
102Hypercalciuria (HP:0002150)2.05978043
103Pancreatic islet-cell hyperplasia (HP:0004510)2.05916754
104Skin nodule (HP:0200036)2.05777989
105Conjugated hyperbilirubinemia (HP:0002908)2.03236727
106Hepatocellular carcinoma (HP:0001402)2.03207564
107Abnormality of renal excretion (HP:0011036)2.00596430
108Abnormality of the nasal septum (HP:0000419)2.00009623
109Tubular atrophy (HP:0000092)1.97027294
110Hypothermia (HP:0002045)1.96035847
111Polyuria (HP:0000103)1.95967380
112Esophageal varix (HP:0002040)1.95234519
113Focal segmental glomerulosclerosis (HP:0000097)1.94582339
114Insulin-resistant diabetes mellitus (HP:0000831)1.94409452
115Exercise-induced muscle cramps (HP:0003710)1.92836679
116Renal cortical cysts (HP:0000803)1.92544262
117Rickets (HP:0002748)1.92514174
118Abnormality of potassium homeostasis (HP:0011042)1.92301244
119Delayed epiphyseal ossification (HP:0002663)1.92222372
120Increased connective tissue (HP:0009025)1.90698498
121Sudden death (HP:0001699)1.90402000
122Hemorrhage of the eye (HP:0011885)1.90305369
123Enlarged kidneys (HP:0000105)1.89970448
124Glycosuria (HP:0003076)1.89805139
125Abnormality of urine glucose concentration (HP:0011016)1.89805139
126Abnormality of Sharpey fibers (HP:0100685)1.89685051
127Abnormality of methionine metabolism (HP:0010901)1.89265355
128Vascular tortuosity (HP:0004948)1.89008951
129Hypokalemia (HP:0002900)1.88692137
130Chondrocalcinosis (HP:0000934)1.88690521
131Delayed CNS myelination (HP:0002188)1.88005532
132Pigmentary retinal degeneration (HP:0001146)1.87270371
133Sensorimotor neuropathy (HP:0007141)1.85125396
134Hypomagnesemia (HP:0002917)1.85010244
135Hyperkalemia (HP:0002153)1.83646621
136Accelerated skeletal maturation (HP:0005616)1.83498743
137Systemic lupus erythematosus (HP:0002725)1.82618492
138Abnormal ossification of hand bones (HP:0005921)1.82447565
139Sparse lateral eyebrow (HP:0005338)1.76757425
140Amelogenesis imperfecta (HP:0000705)1.76660872
141Osteomalacia (HP:0002749)1.75493911
142Overgrowth (HP:0001548)1.73243486
143Generalized hypopigmentation of hair (HP:0011358)1.72744720
144Enlarged penis (HP:0000040)1.71949944
145Arterial tortuosity (HP:0005116)1.71829048
146Advanced eruption of teeth (HP:0006288)1.70627568
147Aplasia of the musculature (HP:0100854)1.70180963
148Glomerulosclerosis (HP:0000096)1.65969210
149Testicular neoplasm (HP:0010788)1.64031651
150Visceral angiomatosis (HP:0100761)1.63729710
151Hypophosphatemic rickets (HP:0004912)1.63614930
152Hypoplasia of the iris (HP:0007676)1.63255166
153Hypotension (HP:0002615)1.60716600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.61580249
2WNK43.44376270
3LATS13.33028785
4ERN12.96114775
5INSRR2.88272105
6TRIB32.80129588
7TAOK32.79219470
8SIK12.59479322
9FRK2.56690749
10FGFR42.12757979
11STK38L2.08960539
12MAP3K31.98624063
13TTN1.88984661
14WNK31.83697594
15PKN21.79902095
16TIE11.65651800
17NUAK11.51796433
18STK391.49326560
19ACVR1B1.46861250
20PTK61.46859444
21MYLK1.43989944
22EPHB11.43051887
23TGFBR21.42700302
24CDK121.42163626
25PDGFRA1.33426504
26MST1R1.28723721
27PIK3CA1.28703950
28OXSR11.26600432
29EPHA31.21023300
30EEF2K1.19726541
31DMPK1.18500982
32FGFR21.17183569
33NEK91.15899297
34TRPM71.14130520
35PTK21.13567007
36PDK21.12749343
37STK31.09956696
38BMPR1B1.09952699
39MET1.09916248
40STK381.08232164
41AKT31.08067370
42RIPK11.07630569
43PAK31.07559699
44PDK41.07554321
45PDK31.07554321
46FER1.06607030
47PRKAA21.05449984
48LRRK21.03668544
49WNK11.03083244
50MST41.02080646
51STK101.01516374
52STK241.00252567
53FGFR30.98672345
54NLK0.97939656
55MAP3K20.96860799
56DDR20.91938594
57FLT30.90899899
58GRK10.89586221
59LMTK20.88925662
60KDR0.88337385
61ICK0.87549309
62MAPK150.85310176
63PIK3CG0.84517978
64GSK3A0.83871035
65PRKG20.82564367
66MAP3K70.80748108
67PRKD30.79339342
68PRKD10.79309718
69CAMK1D0.77439719
70JAK10.76083817
71PRKD20.75921738
72PRKAA10.75768570
73PRKCH0.75090597
74EPHB20.70320446
75MTOR0.69976907
76PAK20.69965527
77MARK20.69851479
78MAP2K30.69645086
79CDC42BPA0.69280793
80RET0.66172532
81BRSK20.65420176
82PDGFRB0.65239026
83EPHA20.64781349
84OBSCN0.63960053
85ERBB40.63007194
86SGK10.62236796
87PRKCE0.60879582
88SGK30.59647894
89MAPKAPK30.57237469
90ROCK10.56394419
91CAMK1G0.53917474
92IRAK30.53251644
93ITK0.52438783
94CDK60.51246475
95NTRK30.49234760
96HIPK20.47115269
97IGF1R0.46275940
98MAPK120.46246945
99MAP2K10.45838494
100MAP3K90.44755909
101JAK20.43661345
102EIF2AK30.43122186
103MAPK110.41057800
104IRAK10.40190679
105TGFBR10.39793706
106LATS20.39672515
107MAPK70.39448749
108DAPK20.39164462
109SGK2230.38360352
110SGK4940.38360352
111MAP2K20.37973711
112PDPK10.37493416
113PNCK0.37352840
114FGFR10.37152135
115SGK20.36882150
116DYRK1B0.36487015
117ADRBK10.36435725
118PDK10.35527242
119MAP3K10.35075703
120CDK90.34748422
121NEK60.34621058
122ERBB30.34338246
123MELK0.33876101
124CHUK0.33765026
125MAPKAPK50.32916538
126RPS6KB10.31592529
127YES10.31513939
128BRD40.31472752
129PRKCZ0.30869292
130ERBB20.30795313
131PINK10.30682279

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.02055828
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97455533
3Propanoate metabolism_Homo sapiens_hsa006402.83017373
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.83012472
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.75226977
6Nitrogen metabolism_Homo sapiens_hsa009102.73013935
7Tryptophan metabolism_Homo sapiens_hsa003802.57288734
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55764191
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35773470
10Fatty acid metabolism_Homo sapiens_hsa012122.34130194
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.23769879
12Arginine biosynthesis_Homo sapiens_hsa002202.22454292
13Butanoate metabolism_Homo sapiens_hsa006502.18599644
14Sulfur metabolism_Homo sapiens_hsa009202.08807797
15PPAR signaling pathway_Homo sapiens_hsa033202.06925309
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05414420
17Maturity onset diabetes of the young_Homo sapiens_hsa049502.05227287
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03042830
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00620676
20Peroxisome_Homo sapiens_hsa041461.89661451
21Vitamin B6 metabolism_Homo sapiens_hsa007501.89477683
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.72046621
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71571956
24Complement and coagulation cascades_Homo sapiens_hsa046101.68992602
25Pyruvate metabolism_Homo sapiens_hsa006201.64195432
26beta-Alanine metabolism_Homo sapiens_hsa004101.63757173
27Starch and sucrose metabolism_Homo sapiens_hsa005001.50412056
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49620480
29Bile secretion_Homo sapiens_hsa049761.49258714
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45549295
31Caffeine metabolism_Homo sapiens_hsa002321.42673534
32Lysine degradation_Homo sapiens_hsa003101.41159752
33Histidine metabolism_Homo sapiens_hsa003401.34700153
34Selenocompound metabolism_Homo sapiens_hsa004501.31883419
35Fatty acid elongation_Homo sapiens_hsa000621.29717107
36Carbon metabolism_Homo sapiens_hsa012001.26746409
37Chemical carcinogenesis_Homo sapiens_hsa052041.23770485
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21294134
39Tyrosine metabolism_Homo sapiens_hsa003501.18455662
40Phenylalanine metabolism_Homo sapiens_hsa003601.17869776
41Fat digestion and absorption_Homo sapiens_hsa049751.16889242
42Vitamin digestion and absorption_Homo sapiens_hsa049771.16350653
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13758308
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13668244
45ABC transporters_Homo sapiens_hsa020101.08743355
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08691371
47Arginine and proline metabolism_Homo sapiens_hsa003301.07841546
48Retinol metabolism_Homo sapiens_hsa008301.03003715
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96552605
50Renin-angiotensin system_Homo sapiens_hsa046140.96257748
51Insulin resistance_Homo sapiens_hsa049310.92694763
52ECM-receptor interaction_Homo sapiens_hsa045120.92660270
53Protein digestion and absorption_Homo sapiens_hsa049740.91495102
54Dorso-ventral axis formation_Homo sapiens_hsa043200.90350865
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86170155
56Ovarian steroidogenesis_Homo sapiens_hsa049130.83989448
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.83310020
58Folate biosynthesis_Homo sapiens_hsa007900.77702483
59Sphingolipid metabolism_Homo sapiens_hsa006000.77701267
60Glycerolipid metabolism_Homo sapiens_hsa005610.76964409
61Renin secretion_Homo sapiens_hsa049240.72962233
62Biosynthesis of amino acids_Homo sapiens_hsa012300.72912690
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.72726643
64Pancreatic secretion_Homo sapiens_hsa049720.72263709
65Fatty acid biosynthesis_Homo sapiens_hsa000610.71134757
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.70659219
67Arachidonic acid metabolism_Homo sapiens_hsa005900.69444715
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.66282416
69Protein export_Homo sapiens_hsa030600.64587156
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63089675
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.62913920
72Steroid biosynthesis_Homo sapiens_hsa001000.61179880
73Focal adhesion_Homo sapiens_hsa045100.58900988
74TGF-beta signaling pathway_Homo sapiens_hsa043500.58249861
75Staphylococcus aureus infection_Homo sapiens_hsa051500.56848256
76Prion diseases_Homo sapiens_hsa050200.54246813
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52788480
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52238350
79Glutathione metabolism_Homo sapiens_hsa004800.50799274
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49824841
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.49109424
82Adherens junction_Homo sapiens_hsa045200.48725224
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47776666
84AMPK signaling pathway_Homo sapiens_hsa041520.47061197
85Glucagon signaling pathway_Homo sapiens_hsa049220.46200509
86Dilated cardiomyopathy_Homo sapiens_hsa054140.43903728
87Inositol phosphate metabolism_Homo sapiens_hsa005620.43039845
88Tight junction_Homo sapiens_hsa045300.42865086
89FoxO signaling pathway_Homo sapiens_hsa040680.42669431
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41893863
91Choline metabolism in cancer_Homo sapiens_hsa052310.41646342
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40950736
93Galactose metabolism_Homo sapiens_hsa000520.40900301
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39578645
95Other glycan degradation_Homo sapiens_hsa005110.37111280
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.37091652
97Ether lipid metabolism_Homo sapiens_hsa005650.35345469
98Serotonergic synapse_Homo sapiens_hsa047260.33582194
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33173183
100Metabolic pathways_Homo sapiens_hsa011000.30406738
101Thyroid hormone synthesis_Homo sapiens_hsa049180.29993422
102Salivary secretion_Homo sapiens_hsa049700.26977103
103Amoebiasis_Homo sapiens_hsa051460.26349503
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26243394
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.25441441
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24769711
107Linoleic acid metabolism_Homo sapiens_hsa005910.23177957
108Circadian rhythm_Homo sapiens_hsa047100.22452843
109Proteoglycans in cancer_Homo sapiens_hsa052050.21962387
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21863636
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21092669
112Insulin signaling pathway_Homo sapiens_hsa049100.19514336
113Small cell lung cancer_Homo sapiens_hsa052220.18725382
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18271610
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17877876
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17654516
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17281590
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16998743
119Fructose and mannose metabolism_Homo sapiens_hsa000510.16778875
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14537118
121Mineral absorption_Homo sapiens_hsa049780.14195172
122Prostate cancer_Homo sapiens_hsa052150.13160056
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12621077
124Bladder cancer_Homo sapiens_hsa052190.12555514

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