COG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.84350672
2COPI coating of Golgi vesicle (GO:0048205)7.84350672
3gamma-aminobutyric acid transport (GO:0015812)5.55368218
4activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.49803307
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.33508558
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.25743025
7positive regulation of nuclease activity (GO:0032075)5.22368442
8COPII vesicle coating (GO:0048208)4.95773920
9glutamate secretion (GO:0014047)4.84431089
10regulation of nuclease activity (GO:0032069)4.76487037
11protein retention in ER lumen (GO:0006621)4.76382330
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.57015570
13vesicle coating (GO:0006901)4.56249136
14endoplasmic reticulum unfolded protein response (GO:0030968)4.54248245
15synaptic vesicle exocytosis (GO:0016079)4.48675989
16protein maturation by protein folding (GO:0022417)4.35749509
17cellular response to unfolded protein (GO:0034620)4.35557877
18negative regulation of synaptic transmission, GABAergic (GO:0032229)4.35171090
19ER-nucleus signaling pathway (GO:0006984)4.18099818
20cellular response to topologically incorrect protein (GO:0035967)4.13496764
21neurotransmitter secretion (GO:0007269)4.03947228
22positive regulation of histone deacetylation (GO:0031065)3.90960792
23regulation of ARF GTPase activity (GO:0032312)3.80785026
24antigen processing and presentation via MHC class Ib (GO:0002475)3.72453268
25regulation of NFAT protein import into nucleus (GO:0051532)3.72078999
26regulation of synaptic vesicle exocytosis (GO:2000300)3.68173144
27response to endoplasmic reticulum stress (GO:0034976)3.64604793
28macroautophagy (GO:0016236)3.60274648
29regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.57242538
30glycine transport (GO:0015816)3.53438740
31L-alpha-amino acid transmembrane transport (GO:1902475)3.52713014
32regulation of synaptic vesicle transport (GO:1902803)3.50870062
33insulin secretion (GO:0030073)3.50670696
34ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.50087506
35endocrine pancreas development (GO:0031018)3.50084039
36neuronal action potential propagation (GO:0019227)3.45316770
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44630277
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44630277
39regulation of autophagic vacuole assembly (GO:2000785)3.43254508
40negative regulation of erythrocyte differentiation (GO:0045647)3.39033372
41ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.36836760
42response to unfolded protein (GO:0006986)3.35685322
43glycosphingolipid biosynthetic process (GO:0006688)3.35339630
44cerebellar Purkinje cell layer development (GO:0021680)3.32045323
45synaptic vesicle maturation (GO:0016188)3.30546631
46peptide hormone processing (GO:0016486)3.29699820
47negative regulation of cell size (GO:0045792)3.29503349
48positive regulation of mitochondrial fission (GO:0090141)3.28651199
49regulation of type B pancreatic cell apoptotic process (GO:2000674)3.26366833
50positive regulation of insulin secretion (GO:0032024)3.24876705
51protein localization to synapse (GO:0035418)3.24038525
52negative regulation of glycoprotein biosynthetic process (GO:0010561)3.23764833
53regulation of vacuole organization (GO:0044088)3.21947569
54exocrine pancreas development (GO:0031017)3.20845050
55protein targeting to Golgi (GO:0000042)3.19824024
56response to topologically incorrect protein (GO:0035966)3.19378144
57peptidyl-asparagine modification (GO:0018196)3.15129284
58regulation of short-term neuronal synaptic plasticity (GO:0048172)3.15121483
59establishment of protein localization to Golgi (GO:0072600)3.14390796
60protein N-linked glycosylation via asparagine (GO:0018279)3.12953576
61N-glycan processing (GO:0006491)3.12131560
62sodium ion export (GO:0071436)3.09220831
63establishment of mitochondrion localization (GO:0051654)3.08134974
64sequestering of metal ion (GO:0051238)3.07934836
65protein localization to Golgi apparatus (GO:0034067)3.07573643
66negative regulation of microtubule polymerization (GO:0031115)3.06753683
67regulation of ARF protein signal transduction (GO:0032012)3.06619742
68retrograde transport, vesicle recycling within Golgi (GO:0000301)3.06000277
69glandular epithelial cell differentiation (GO:0002067)3.03051001
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.01921188
71positive regulation of synapse maturation (GO:0090129)3.01060860
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99768687
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98926180
74protein insertion into membrane (GO:0051205)2.96410765
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96246419
76cell migration in hindbrain (GO:0021535)2.96078502
77antigen processing and presentation of endogenous antigen (GO:0019883)2.95521162
78negative regulation of Rho protein signal transduction (GO:0035024)2.89472617
79positive regulation of protein deacetylation (GO:0090312)2.88634197
80mannosylation (GO:0097502)2.88515020
81synaptic transmission, glutamatergic (GO:0035249)2.87223380
82regulation of neurotransmitter levels (GO:0001505)2.86711395
83cytoskeletal anchoring at plasma membrane (GO:0007016)2.86653761
84regulation of microtubule-based movement (GO:0060632)2.86567163
85* Golgi organization (GO:0007030)2.85059884
86ionotropic glutamate receptor signaling pathway (GO:0035235)2.84062948
87regulation of cilium movement (GO:0003352)2.83936072
88protein N-linked glycosylation (GO:0006487)2.80781389
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79779728
90vesicle transport along microtubule (GO:0047496)2.78070626
91maternal placenta development (GO:0001893)2.77908543
92astrocyte differentiation (GO:0048708)2.77400360
93tricarboxylic acid metabolic process (GO:0072350)2.76820352
94neuromuscular synaptic transmission (GO:0007274)2.75673064
95regulation of insulin secretion (GO:0050796)2.75514725
96epithelial cell fate commitment (GO:0072148)2.74882808
97neurotransmitter transport (GO:0006836)2.74036793
98inner ear receptor cell development (GO:0060119)2.73462272
99nonmotile primary cilium assembly (GO:0035058)2.72520839
100regulation of vesicle fusion (GO:0031338)2.68619778
101detection of calcium ion (GO:0005513)2.67801040
102regulation of synapse maturation (GO:0090128)2.67690357
103proline transport (GO:0015824)2.67088571
104response to gravity (GO:0009629)2.65461213
105peptidyl-lysine dimethylation (GO:0018027)2.64837996
106pyrimidine nucleobase catabolic process (GO:0006208)2.64346936
107maintenance of protein location in nucleus (GO:0051457)2.63595913
108locomotory exploration behavior (GO:0035641)2.63563323
109regulation of defense response to virus by virus (GO:0050690)2.62371829
110axonal fasciculation (GO:0007413)2.62192262
111peptide hormone secretion (GO:0030072)2.61742909
112* intra-Golgi vesicle-mediated transport (GO:0006891)2.61587082
113glandular epithelial cell development (GO:0002068)2.61425110
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61381314
115sexual reproduction (GO:0019953)2.59038700
116beta-amyloid metabolic process (GO:0050435)2.58427037
117negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.58284870
118peptide secretion (GO:0002790)2.56142256
119regulation of mitochondrial fission (GO:0090140)2.54969785
120positive regulation of peptide hormone secretion (GO:0090277)2.54592814
121response to dietary excess (GO:0002021)2.54047268
122ER to Golgi vesicle-mediated transport (GO:0006888)2.53402172
123adaptation of signaling pathway (GO:0023058)2.53201210
124activation of protein kinase A activity (GO:0034199)2.51939234
125type B pancreatic cell development (GO:0003323)2.51842596
126toxin metabolic process (GO:0009404)2.50907902
127neuronal ion channel clustering (GO:0045161)2.50260354
128regulation of glycogen (starch) synthase activity (GO:2000465)2.49953950
129alanine transport (GO:0032328)2.49908242
130zinc ion homeostasis (GO:0055069)2.49229094
131axoneme assembly (GO:0035082)2.48278849
132inositol phosphate catabolic process (GO:0071545)2.47468167
133positive regulation of CREB transcription factor activity (GO:0032793)2.47142833
134ganglioside metabolic process (GO:0001573)2.46915070
135nucleobase catabolic process (GO:0046113)2.46484476
136nerve growth factor signaling pathway (GO:0038180)2.46196168
137positive regulation of peptide secretion (GO:0002793)2.46063739
138glucose 6-phosphate metabolic process (GO:0051156)2.44107524
139response to ischemia (GO:0002931)2.42750423
140regulation of early endosome to late endosome transport (GO:2000641)2.42503263
141positive regulation of membrane potential (GO:0045838)2.42451352
142regulation of peptide hormone secretion (GO:0090276)2.41833790
143postsynaptic membrane organization (GO:0001941)2.41798246
144synapse assembly (GO:0007416)2.41699993
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40658198
146response to misfolded protein (GO:0051788)2.39322760
147lactate metabolic process (GO:0006089)2.39317328
148cellular response to vitamin D (GO:0071305)2.39252537
149protein localization to cilium (GO:0061512)2.38888174
150cerebellar Purkinje cell differentiation (GO:0021702)2.38692130
151retinal cone cell development (GO:0046549)2.38534432
152dendritic spine organization (GO:0097061)2.38236574
153regulation of peptide secretion (GO:0002791)2.37958897
154dopaminergic neuron differentiation (GO:0071542)2.37486965
1554-hydroxyproline metabolic process (GO:0019471)2.37261702
156regulation of neurotransmitter secretion (GO:0046928)2.36957693
157neuron cell-cell adhesion (GO:0007158)2.36930448
158cellular response to nutrient (GO:0031670)2.36546705
159phospholipid translocation (GO:0045332)2.36541778
160lipid translocation (GO:0034204)2.36541778
161* Golgi vesicle transport (GO:0048193)2.35534274
162regulation of cholesterol homeostasis (GO:2000188)2.34655133
163chemosensory behavior (GO:0007635)2.33452090
164intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.32523216
165protein polyglutamylation (GO:0018095)2.32484613
166cellular potassium ion homeostasis (GO:0030007)2.31834174
167phosphorylated carbohydrate dephosphorylation (GO:0046838)2.31727047
168inositol phosphate dephosphorylation (GO:0046855)2.31727047
169membrane depolarization during action potential (GO:0086010)2.31611645
170maintenance of protein localization in organelle (GO:0072595)2.31487604
171establishment of vesicle localization (GO:0051650)2.31485863
172neuron-neuron synaptic transmission (GO:0007270)2.31329331
173epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.31066827
174regulation of neurotransmitter transport (GO:0051588)2.30672167
175melanosome transport (GO:0032402)2.30462804
176negative regulation of TOR signaling (GO:0032007)2.30147418
177organelle transport along microtubule (GO:0072384)2.30093789
178signal release (GO:0023061)2.29650238
179sialylation (GO:0097503)2.29196733
180establishment of melanosome localization (GO:0032401)2.28160257
181vesicle docking involved in exocytosis (GO:0006904)2.28147209
182succinate metabolic process (GO:0006105)2.28079528
183pigment granule transport (GO:0051904)2.27456377
184misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.27399214
185energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.27304616
186ATP hydrolysis coupled proton transport (GO:0015991)2.27304616
187regulation of neuronal synaptic plasticity (GO:0048168)2.27196759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.19208267
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.16458541
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.13545809
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87907328
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57273123
6VDR_21846776_ChIP-Seq_THP-1_Human2.54665474
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.53087677
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49817119
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49211271
10TCF7_22412390_ChIP-Seq_EML_Mouse2.36936714
11* LXR_22292898_ChIP-Seq_THP-1_Human2.36323900
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27495896
13KDM2B_26808549_Chip-Seq_DND41_Human2.27196303
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16146524
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05001263
16SPI1_23127762_ChIP-Seq_K562_Human1.96986448
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96258726
18CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.94405961
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93866613
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87555342
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83413381
22GATA1_22025678_ChIP-Seq_K562_Human1.80747639
23VDR_24763502_ChIP-Seq_THP-1_Human1.79829927
24* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.79426369
25KDM2B_26808549_Chip-Seq_K562_Human1.79407581
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77743063
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74508702
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.70546193
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.67140153
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63892652
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63012153
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.62508704
33GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59242980
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59214012
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58444695
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57353358
37* UTX_26944678_Chip-Seq_JUKART_Human1.57326775
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57184770
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.56875244
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50961594
41GATA1_19941826_ChIP-Seq_K562_Human1.49253848
42ZNF263_19887448_ChIP-Seq_K562_Human1.48946835
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48845215
44SMC4_20622854_ChIP-Seq_HELA_Human1.47191251
45SCL_19346495_ChIP-Seq_HPC-7_Human1.46455906
46DROSHA_22980978_ChIP-Seq_HELA_Human1.46398121
47P68_20966046_ChIP-Seq_HELA_Human1.45168390
48FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.44955536
49RARB_24833708_ChIP-Seq_LIVER_Mouse1.41749286
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41311528
51GBX2_23144817_ChIP-Seq_PC3_Human1.41293298
52IGF1R_20145208_ChIP-Seq_DFB_Human1.39523730
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39508443
54CREB1_26743006_Chip-Seq_LNCaP_Human1.38835938
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38546882
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37769810
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37336369
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.37109531
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36763798
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.36634953
61OCT4_19829295_ChIP-Seq_ESCs_Human1.35315663
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.33695756
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32670017
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31906373
65RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30155655
66MAF_26560356_Chip-Seq_TH1_Human1.29622503
67* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28972263
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28055283
69TP53_22127205_ChIP-Seq_IMR90_Human1.27751738
70E2F1_20622854_ChIP-Seq_HELA_Human1.27655880
71RACK7_27058665_Chip-Seq_MCF-7_Human1.27563505
72BCOR_27268052_Chip-Seq_Bcells_Human1.27453366
73* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.25805741
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23972539
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.23797672
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23515357
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22903175
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22660454
79* CIITA_25753668_ChIP-Seq_RAJI_Human1.22236424
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20745142
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20464706
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20332550
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20089249
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.19147200
85REST_21632747_ChIP-Seq_MESCs_Mouse1.19056959
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18851452
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18400710
88FOXP1_21924763_ChIP-Seq_HESCs_Human1.18183086
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18075700
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17156350
91OCT4_20526341_ChIP-Seq_ESCs_Human1.16290257
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15370631
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15169687
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14601373
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14524831
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.14321151
97CTCF_20526341_ChIP-Seq_ESCs_Human1.14270103
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13732765
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13559333
100GABP_19822575_ChIP-Seq_HepG2_Human1.12887837
101ATF3_27146783_Chip-Seq_COLON_Human1.12613955
102* ERA_21632823_ChIP-Seq_H3396_Human1.12565453
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12386586
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11890275
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11593529
106* RAC3_21632823_ChIP-Seq_H3396_Human1.10264872
107* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10230270
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10000485
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09679155
110PHF8_20622854_ChIP-Seq_HELA_Human1.08848070
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08556802
112BCL6_27268052_Chip-Seq_Bcells_Human1.08386288
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08024575
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07784784
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07759495
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07264518
117* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06762200
118* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06433693
119GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06056450
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04685265
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04448661
122* TP63_22573176_ChIP-Seq_HFKS_Human1.04421810
123NCOR1_26117541_ChIP-Seq_K562_Human1.04343851
124MYB_26560356_Chip-Seq_TH2_Human1.03213997
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03165908
126* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.03122343
127* GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.03057731
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02416159
129TET1_21490601_ChIP-Seq_MESCs_Mouse1.01577192
130HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00401405
131CTCF_27219007_Chip-Seq_Bcells_Human1.00332774
132ZNF274_21170338_ChIP-Seq_K562_Hela1.00246111
133RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00034254
134EZH2_22144423_ChIP-Seq_EOC_Human0.99290354
135SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99238050
136* GATA3_27048872_Chip-Seq_THYMUS_Human0.98590960
137SA1_27219007_Chip-Seq_Bcells_Human0.97913749
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97255941
139SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94769911
140TP53_23651856_ChIP-Seq_MEFs_Mouse0.94398477
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.93899265
142* MAF_26560356_Chip-Seq_TH2_Human0.93398662
143EZH2_27304074_Chip-Seq_ESCs_Mouse0.93233488
144RNF2_27304074_Chip-Seq_ESCs_Mouse0.92301778
145* MITF_21258399_ChIP-Seq_MELANOMA_Human0.91456990
146JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91035718
147SA1_27219007_Chip-Seq_ERYTHROID_Human0.90428615
148FLI1_21867929_ChIP-Seq_CD8_Mouse0.89897120
149P300_27268052_Chip-Seq_Bcells_Human0.89434512
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.89293733
151SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88519516
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88288267
153FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85813077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.23765775
2MP0002909_abnormal_adrenal_gland3.95732461
3MP0002877_abnormal_melanocyte_morpholog3.93397183
4MP0008961_abnormal_basal_metabolism3.78180741
5MP0003283_abnormal_digestive_organ3.68670912
6MP0000013_abnormal_adipose_tissue2.95885843
7MP0003300_gastrointestinal_ulcer2.91818368
8MP0005423_abnormal_somatic_nervous2.86232032
9MP0009780_abnormal_chondrocyte_physiolo2.80135513
10MP0002693_abnormal_pancreas_physiology2.68099292
11MP0001944_abnormal_pancreas_morphology2.66935829
12MP0003787_abnormal_imprinting2.64496978
13MP0009046_muscle_twitch2.54979297
14MP0004264_abnormal_extraembryonic_tissu2.51169229
15MP0003172_abnormal_lysosome_physiology2.42135633
16MP0002064_seizures2.33279042
17MP0009745_abnormal_behavioral_response2.30939206
18MP0003880_abnormal_central_pattern2.27453339
19MP0002272_abnormal_nervous_system2.20906585
20MP0003879_abnormal_hair_cell2.19795779
21MP0004043_abnormal_pH_regulation2.17259103
22MP0010386_abnormal_urinary_bladder2.13060339
23MP0002837_dystrophic_cardiac_calcinosis2.09300194
24MP0005220_abnormal_exocrine_pancreas2.07902466
25MP0001502_abnormal_circadian_rhythm2.06082743
26MP0004859_abnormal_synaptic_plasticity2.05362216
27MP0002234_abnormal_pharynx_morphology2.05314590
28MP0002572_abnormal_emotion/affect_behav2.02777393
29MP0001984_abnormal_olfaction1.93425916
30MP0000569_abnormal_digit_pigmentation1.89324017
31MP0001968_abnormal_touch/_nociception1.87889627
32MP0000678_abnormal_parathyroid_gland1.82946975
33MP0003866_abnormal_defecation1.82300399
34MP0005058_abnormal_lysosome_morphology1.78930079
35MP0001501_abnormal_sleep_pattern1.78568402
36MP0004858_abnormal_nervous_system1.73344811
37MP0001486_abnormal_startle_reflex1.72272232
38MP0005499_abnormal_olfactory_system1.63661639
39MP0005394_taste/olfaction_phenotype1.63661639
40MP0002638_abnormal_pupillary_reflex1.62798933
41MP0005083_abnormal_biliary_tract1.59193376
42MP0000003_abnormal_adipose_tissue1.57970881
43MP0002078_abnormal_glucose_homeostasis1.57902392
44MP0004270_analgesia1.56661985
45MP0002653_abnormal_ependyma_morphology1.56253644
46MP0001765_abnormal_ion_homeostasis1.49363260
47MP0004142_abnormal_muscle_tone1.49243950
48MP0001970_abnormal_pain_threshold1.49212862
49MP0005551_abnormal_eye_electrophysiolog1.47803794
50MP0000015_abnormal_ear_pigmentation1.47018129
51MP0004924_abnormal_behavior1.46778115
52MP0005386_behavior/neurological_phenoty1.46778115
53MP0001666_abnormal_nutrient_absorption1.46006775
54MP0005410_abnormal_fertilization1.44762462
55MP0005076_abnormal_cell_differentiation1.40160019
56MP0003329_amyloid_beta_deposits1.36751505
57MP0001348_abnormal_lacrimal_gland1.36711172
58MP0001849_ear_inflammation1.34788434
59MP0001188_hyperpigmentation1.31889059
60MP0002102_abnormal_ear_morphology1.31447678
61MP0005645_abnormal_hypothalamus_physiol1.30207334
62MP0000751_myopathy1.29896038
63MP0006054_spinal_hemorrhage1.28168926
64MP0001529_abnormal_vocalization1.25054888
65MP0010234_abnormal_vibrissa_follicle1.24259380
66MP0002882_abnormal_neuron_morphology1.23620029
67MP0002184_abnormal_innervation1.23463871
68MP0008260_abnormal_autophagy1.22893229
69MP0004233_abnormal_muscle_weight1.22634346
70MP0008789_abnormal_olfactory_epithelium1.19649003
71MP0002735_abnormal_chemical_nociception1.18972198
72MP0006072_abnormal_retinal_apoptosis1.17136328
73MP0000537_abnormal_urethra_morphology1.16284643
74MP0003705_abnormal_hypodermis_morpholog1.15584309
75MP0002066_abnormal_motor_capabilities/c1.15239238
76MP0009643_abnormal_urine_homeostasis1.14703446
77MP0001986_abnormal_taste_sensitivity1.14550419
78MP0000538_abnormal_urinary_bladder1.14206382
79MP0002928_abnormal_bile_duct1.10756891
80MP0003566_abnormal_cell_adhesion1.07690242
81MP0000778_abnormal_nervous_system1.06725648
82MP0005379_endocrine/exocrine_gland_phen1.06350000
83MP0001905_abnormal_dopamine_level1.05304908
84MP0002067_abnormal_sensory_capabilities1.05158264
85MP0005187_abnormal_penis_morphology1.04143685
86MP0001756_abnormal_urination1.03916817
87MP0008875_abnormal_xenobiotic_pharmacok1.03130300
88MP0003635_abnormal_synaptic_transmissio1.02618722
89MP0004510_myositis1.01867613
90MP0002822_catalepsy1.01866346
91MP0003953_abnormal_hormone_level1.01734927
92MP0004811_abnormal_neuron_physiology1.00721239
93MP0008569_lethality_at_weaning0.98006831
94MP0002269_muscular_atrophy0.97059532
95MP0005310_abnormal_salivary_gland0.96742246
96MP0005365_abnormal_bile_salt0.94551053
97MP0003656_abnormal_erythrocyte_physiolo0.93702096
98MP0000750_abnormal_muscle_regeneration0.93468359
99MP0002229_neurodegeneration0.93252866
100MP0005171_absent_coat_pigmentation0.93139798
101MP0000358_abnormal_cell_content/0.93105567
102MP0002876_abnormal_thyroid_physiology0.92794813
103MP0002896_abnormal_bone_mineralization0.92290038
104MP0000685_abnormal_immune_system0.88912265
105MP0003123_paternal_imprinting0.88129735
106MP0005375_adipose_tissue_phenotype0.86967884
107MP0009840_abnormal_foam_cell0.86634540
108MP0002089_abnormal_postnatal_growth/wei0.86557816
109MP0005448_abnormal_energy_balance0.86407382
110MP0001270_distended_abdomen0.86236401
111MP0002736_abnormal_nociception_after0.85140600
112MP0003119_abnormal_digestive_system0.84530960
113MP0003959_abnormal_lean_body0.84330482
114MP0003121_genomic_imprinting0.84126183
115MP0005535_abnormal_body_temperature0.81768724
116MP0002332_abnormal_exercise_endurance0.79396215
117MP0000955_abnormal_spinal_cord0.78243392
118MP0005636_abnormal_mineral_homeostasis0.77821985
119MP0010329_abnormal_lipoprotein_level0.77140360
120MP0001873_stomach_inflammation0.76265844
121MP0008877_abnormal_DNA_methylation0.76249205
122MP0008775_abnormal_heart_ventricle0.75786229
123MP0003633_abnormal_nervous_system0.75044772
124MP0000639_abnormal_adrenal_gland0.74374827
125MP0005623_abnormal_meninges_morphology0.74195928
126MP0003303_peritoneal_inflammation0.73778882
127MP0000604_amyloidosis0.73439833
128MP0003137_abnormal_impulse_conducting0.72833236
129MP0004130_abnormal_muscle_cell0.72666793
130MP0004133_heterotaxia0.72308676
131MP0003091_abnormal_cell_migration0.72235127
132MP0001440_abnormal_grooming_behavior0.71491957
133MP0004134_abnormal_chest_morphology0.70642213
134MP0002152_abnormal_brain_morphology0.68999375
135MP0003122_maternal_imprinting0.68669790
136MP0006276_abnormal_autonomic_nervous0.68553602
137MP0004145_abnormal_muscle_electrophysio0.67683518
138MP0000477_abnormal_intestine_morphology0.65870130
139MP0002118_abnormal_lipid_homeostasis0.65768329
140MP0003045_fibrosis0.65601665
141MP0002970_abnormal_white_adipose0.65440932
142MP0004885_abnormal_endolymph0.65316037
143MP0002733_abnormal_thermal_nociception0.64382260
144MP0000462_abnormal_digestive_system0.62876245
145MP0000747_muscle_weakness0.59436915
146MP0005670_abnormal_white_adipose0.59369724
147MP0005646_abnormal_pituitary_gland0.59219858
148MP0000371_diluted_coat_color0.58883301
149MP0002069_abnormal_eating/drinking_beha0.57367001
150MP0001664_abnormal_digestion0.55547212
151MP0002734_abnormal_mechanical_nocicepti0.54908424
152MP0001299_abnormal_eye_distance/0.54009360
153MP0000759_abnormal_skeletal_muscle0.53703061
154MP0010352_gastrointestinal_tract_polyps0.53601177
155MP0005621_abnormal_cell_physiology0.53544426
156MP0000534_abnormal_ureter_morphology0.53255964
157MP0003252_abnormal_bile_duct0.53186058
158MP0002063_abnormal_learning/memory/cond0.53159375
159MP0010155_abnormal_intestine_physiology0.52551474
160MP0005174_abnormal_tail_pigmentation0.52489564
161MP0002557_abnormal_social/conspecific_i0.51953116

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.47371224
2Hyperinsulinemic hypoglycemia (HP:0000825)4.02517302
3Epileptic encephalopathy (HP:0200134)3.94250563
4Gait imbalance (HP:0002141)3.88772335
5Ankle clonus (HP:0011448)3.67173008
6Congenital primary aphakia (HP:0007707)3.42263571
7Hypoglycemic seizures (HP:0002173)3.37269209
8Nephrogenic diabetes insipidus (HP:0009806)3.36920994
9Cerebral hypomyelination (HP:0006808)3.35316394
10Medial flaring of the eyebrow (HP:0010747)3.34502769
11Atonic seizures (HP:0010819)3.23210803
12Hypercortisolism (HP:0001578)3.22012892
13Abnormality of the pancreatic islet cells (HP:0006476)3.15062535
14Abnormality of endocrine pancreas physiology (HP:0012093)3.15062535
15Febrile seizures (HP:0002373)3.13345467
16Cerebellar dysplasia (HP:0007033)3.11807219
17Absent speech (HP:0001344)3.10281260
18Hand muscle atrophy (HP:0009130)3.07668860
19Large for gestational age (HP:0001520)3.06449057
20Symptomatic seizures (HP:0011145)3.02301224
21Ketoacidosis (HP:0001993)2.97283401
22Focal motor seizures (HP:0011153)2.96625502
23Late onset (HP:0003584)2.95466948
24Pancreatic fibrosis (HP:0100732)2.90600451
25Focal seizures (HP:0007359)2.89325761
26Mucopolysacchariduria (HP:0008155)2.88416115
27Urinary glycosaminoglycan excretion (HP:0003541)2.88416115
28Hyperacusis (HP:0010780)2.88094802
29Severe muscular hypotonia (HP:0006829)2.77239420
30Nasal polyposis (HP:0100582)2.77103834
31Visual hallucinations (HP:0002367)2.74554873
32Agitation (HP:0000713)2.68801221
33Spastic gait (HP:0002064)2.67955211
34Abnormality of polysaccharide metabolism (HP:0011012)2.67815136
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.67815136
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.67815136
37Abnormality of midbrain morphology (HP:0002418)2.64018034
38Molar tooth sign on MRI (HP:0002419)2.64018034
39Hyperventilation (HP:0002883)2.62551302
40Dysostosis multiplex (HP:0000943)2.62151094
41Upper limb amyotrophy (HP:0009129)2.61501174
42Distal upper limb amyotrophy (HP:0007149)2.61501174
43Ankyloglossia (HP:0010296)2.60724626
44Polyphagia (HP:0002591)2.60667641
45Poor coordination (HP:0002370)2.60045274
46Pancreatic cysts (HP:0001737)2.57612033
47Abnormality of calcium-phosphate metabolism (HP:0100530)2.57447172
48Myokymia (HP:0002411)2.56195970
49CNS hypomyelination (HP:0003429)2.56112976
50Long toe (HP:0010511)2.52497318
51Impaired smooth pursuit (HP:0007772)2.51936146
52Hypoglycemic coma (HP:0001325)2.48341824
53Hypsarrhythmia (HP:0002521)2.48194660
54Abnormality of the nasal mucosa (HP:0000433)2.47986310
55Cystic liver disease (HP:0006706)2.46963473
56Insomnia (HP:0100785)2.46128470
57Pancreatic islet-cell hyperplasia (HP:0004510)2.45629860
58Supranuclear gaze palsy (HP:0000605)2.45413459
59Retinal dysplasia (HP:0007973)2.43918612
60Insulin-resistant diabetes mellitus (HP:0000831)2.43335085
61EEG with generalized epileptiform discharges (HP:0011198)2.37176851
62Spastic tetraplegia (HP:0002510)2.36973418
63Lissencephaly (HP:0001339)2.36870478
64Severe short stature (HP:0003510)2.36553392
65Nephronophthisis (HP:0000090)2.36226430
66Hyperparathyroidism (HP:0000843)2.36192880
67Cerebral aneurysm (HP:0004944)2.34669463
68Macroorchidism (HP:0000053)2.33035698
69Akinesia (HP:0002304)2.31625771
70Absence seizures (HP:0002121)2.31608878
71Pachygyria (HP:0001302)2.30370027
72Abnormal eating behavior (HP:0100738)2.29660397
73Abnormality of oral frenula (HP:0000190)2.29133808
74Decreased circulating renin level (HP:0003351)2.27766935
75Papilledema (HP:0001085)2.27272465
76Status epilepticus (HP:0002133)2.26984628
77Oligomenorrhea (HP:0000876)2.24170648
78Gastrointestinal inflammation (HP:0004386)2.23954875
79Thin bony cortex (HP:0002753)2.22730197
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22324965
81Retinal atrophy (HP:0001105)2.19189584
82True hermaphroditism (HP:0010459)2.19170948
83Tubulointerstitial nephritis (HP:0001970)2.18546346
84Exercise-induced myalgia (HP:0003738)2.18128945
85Epileptiform EEG discharges (HP:0011182)2.18054423
86Specific learning disability (HP:0001328)2.17722233
87Bundle branch block (HP:0011710)2.15366215
88Left ventricular hypertrophy (HP:0001712)2.13794823
89Limb hypertonia (HP:0002509)2.13672502
90Global brain atrophy (HP:0002283)2.12097760
91Neoplasm of the heart (HP:0100544)2.11058372
92Depression (HP:0000716)2.10787080
93Delusions (HP:0000746)2.10331076
94Abnormality of ocular smooth pursuit (HP:0000617)2.10218885
95Deep palmar crease (HP:0006191)2.09603932
96Amblyopia (HP:0000646)2.08564670
97Intellectual disability, severe (HP:0010864)2.07862452
98Congenital glaucoma (HP:0001087)2.07826876
99Amyotrophic lateral sclerosis (HP:0007354)2.07376351
100Insulin resistance (HP:0000855)2.07321195
101Intention tremor (HP:0002080)2.07266216
102Neonatal respiratory distress (HP:0002643)2.06474849
103Progressive cerebellar ataxia (HP:0002073)2.06407952
104Dialeptic seizures (HP:0011146)2.05950711
105Poor eye contact (HP:0000817)2.03525052
106Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01474731
107Abdominal distention (HP:0003270)2.01463156
108Genital tract atresia (HP:0001827)1.98669151
109Clonus (HP:0002169)1.97847485
110Limb-girdle muscle atrophy (HP:0003797)1.97576873
111Vaginal atresia (HP:0000148)1.97210191
112Thoracolumbar scoliosis (HP:0002944)1.96877177
113Hyperglycemia (HP:0003074)1.96832879
114Torticollis (HP:0000473)1.96502588
115Abnormality of the lower motor neuron (HP:0002366)1.96226823
116* Progressive microcephaly (HP:0000253)1.96020423
117Truncal ataxia (HP:0002078)1.96005193
118Anterior segment dysgenesis (HP:0007700)1.95429874
119Hemiparesis (HP:0001269)1.95150992
120Inflammation of the large intestine (HP:0002037)1.93911362
121Hypoplasia of the corpus callosum (HP:0002079)1.93429369
122Type II lissencephaly (HP:0007260)1.92878863
123Broad face (HP:0000283)1.92035933
124Aplasia/Hypoplasia of the lens (HP:0008063)1.91734086
125Disproportionate short-trunk short stature (HP:0003521)1.91559585
126Central scotoma (HP:0000603)1.89903107
127* Failure to thrive in infancy (HP:0001531)1.89303583
128Bowel diverticulosis (HP:0005222)1.89164077
129Entropion (HP:0000621)1.87860747
130Occipital encephalocele (HP:0002085)1.87587102
131Abnormality of DNA repair (HP:0003254)1.87552326
132Broad palm (HP:0001169)1.85028919
133Prominent metopic ridge (HP:0005487)1.84680159
134Mildly elevated creatine phosphokinase (HP:0008180)1.83763173
135Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83617099
136Abnormality of the metopic suture (HP:0005556)1.83495300
137Aneurysm (HP:0002617)1.82011242
138Unsteady gait (HP:0002317)1.81749172
139Poor suck (HP:0002033)1.81706260
140Generalized hyperpigmentation (HP:0007440)1.81059897
141Abnormality of the renal medulla (HP:0100957)1.80298908
142Focal dystonia (HP:0004373)1.79528355
143Frequent falls (HP:0002359)1.79406928
144Drooling (HP:0002307)1.79197892
145Stridor (HP:0010307)1.79093122
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.78446780
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.77317824
148Asymmetric septal hypertrophy (HP:0001670)1.76979735
149Postural instability (HP:0002172)1.76065569
150Chronic hepatic failure (HP:0100626)1.76028600
151Polygenic inheritance (HP:0010982)1.74085636
152Muscular hypotonia of the trunk (HP:0008936)1.73313556
153Myopathic facies (HP:0002058)1.72352217
154Polydipsia (HP:0001959)1.71969897
155Abnormal drinking behavior (HP:0030082)1.71969897
156Interstitial pulmonary disease (HP:0006530)1.71742661
157Testicular atrophy (HP:0000029)1.71679827
158Long palpebral fissure (HP:0000637)1.70412570
159Hypoventilation (HP:0002791)1.70120058
160Turricephaly (HP:0000262)1.69420876
161Limb ataxia (HP:0002070)1.69029066
162Colitis (HP:0002583)1.66126353
163Rectal prolapse (HP:0002035)1.65511272
164Progressive neurologic deterioration (HP:0002344)1.65209580
165Cholecystitis (HP:0001082)1.63975535
166Abnormal gallbladder physiology (HP:0012438)1.63975535
167Abnormality of the fingertips (HP:0001211)1.62389266
168Ketosis (HP:0001946)1.62321865
169Fatigue (HP:0012378)1.62069994
170Abnormality of the anterior horn cell (HP:0006802)1.61942585
171Degeneration of anterior horn cells (HP:0002398)1.61942585
172Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61705909
173Hypoplasia of the brainstem (HP:0002365)1.61705909
174Death in childhood (HP:0003819)1.60598724
175Myoglobinuria (HP:0002913)1.60564378
176Striae distensae (HP:0001065)1.59845971
177Ventricular fibrillation (HP:0001663)1.57174096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.51688469
2FLT33.49679785
3TRIB33.32882667
4PRKD33.02252592
5RIPK12.70180518
6MAP4K22.66363726
7PASK2.50635622
8MAP3K102.46316410
9PHKG12.39879978
10PHKG22.39879978
11EEF2K2.37141227
12PKN22.35667738
13PDGFRA2.28789307
14NTRK12.27111559
15SCYL21.94514422
16HIPK21.93103644
17PAK31.92784784
18FGFR41.91829325
19EPHA41.91161849
20MAPK131.80376217
21AKT31.74349658
22PIM21.74269578
23MAP3K91.74262055
24PINK11.70468728
25CAMKK21.68149724
26DYRK1B1.64676270
27INSRR1.58773900
28ICK1.57741787
29CAMKK11.50372733
30PTK61.45242793
31RET1.44601177
32MUSK1.41896458
33EPHB11.41458700
34TESK11.40607063
35MAP3K41.39282640
36KSR21.36461872
37ZAP701.34929049
38CAMK11.33520003
39MAP3K11.32757081
40FRK1.31170331
41TAOK31.31127232
42MAP2K71.30645094
43SIK11.27194708
44STK381.25944375
45MAPKAPK31.24247989
46MAP3K21.21896734
47LMTK21.17676735
48PTK21.16959623
49PRKAA11.15808994
50CDK121.15355880
51MAP2K61.12067849
52PAK61.08122222
53DAPK21.07915269
54PRKCH1.07869930
55SIK31.07625783
56LIMK11.07038639
57MAPK151.07005559
58PRKD21.06969587
59FER1.06062732
60MAP4K11.03255582
61TNK21.02563589
62TXK0.99031381
63PTK2B0.94484414
64MAP2K20.94460506
65BCR0.92671177
66CDC42BPA0.90467149
67MAP3K110.89292739
68FGFR30.88707778
69MAPK120.88073178
70MAP2K40.87952148
71MAP3K70.86864351
72CAMK1G0.85289133
73KSR10.84943850
74CASK0.84466534
75NTRK30.83021197
76WNK40.82732972
77BCKDK0.81820659
78SIK20.81162290
79SGK30.81115909
80UHMK10.80756932
81EPHA30.79697618
82MAPK110.79623878
83DYRK1A0.79353028
84CAMK1D0.78591171
85MET0.78264590
86LRRK20.78108147
87PRKCG0.77172840
88MARK20.76914094
89PRKCI0.76810959
90CSNK1A1L0.76347906
91PLK20.76269081
92PRKCZ0.74977952
93SGK4940.74745662
94SGK2230.74745662
95GRK60.73869757
96MAP2K30.72927431
97TBK10.72014490
98RPS6KA20.71222196
99CAMK40.70740173
100JAK30.69766837
101PDGFRB0.69500876
102RIPK40.69037588
103TTN0.68952335
104NEK60.67023287
105MTOR0.65845934
106CSNK1G30.65610420
107DAPK10.64572723
108SYK0.63105225
109TYRO30.62752223
110JAK20.61890719
111MAP3K130.61305255
112ITK0.60860714
113CSNK1G20.58735748
114ALK0.56521988
115PRKAA20.54687619
116MINK10.54636771
117IRAK10.53439617
118PDK10.51519571
119MARK30.49585119
120PRKD10.48873779
121PRKCE0.48140579
122WNK10.47214938
123MAP2K10.46703102
124STK110.46190736
125TGFBR10.46170887
126PDK30.45461165
127PDK40.45461165
128CDK50.45295330
129PKN10.44800391
130CAMK2G0.41731821
131NTRK20.40866597
132TAOK10.40383715
133SGK20.40358300
134RPS6KA40.40238805
135CAMK2A0.39810819
136CDK140.39591034
137MARK10.39276276
138JAK10.38876667
139DMPK0.38599778
140MAPK80.38528416
141CAMK2B0.36252674
142STK100.36058505
143PDPK10.35622772
144BTK0.35581497
145BRSK10.34352930
146RPS6KA10.33268661
147FGFR20.32585879
148DYRK30.32048698
149TESK20.31426548
150CHUK0.31357893

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.66180214
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.86543238
3Nicotine addiction_Homo sapiens_hsa050332.84134689
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.80137626
5Carbohydrate digestion and absorption_Homo sapiens_hsa049732.54563806
6Insulin secretion_Homo sapiens_hsa049112.51991357
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32761453
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31105039
9Type II diabetes mellitus_Homo sapiens_hsa049302.23594580
10Sulfur relay system_Homo sapiens_hsa041222.22246608
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18213451
12Regulation of autophagy_Homo sapiens_hsa041401.99200814
13Morphine addiction_Homo sapiens_hsa050321.77051420
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74042043
15Collecting duct acid secretion_Homo sapiens_hsa049661.72906108
16N-Glycan biosynthesis_Homo sapiens_hsa005101.69601378
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60127684
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59625966
19Sulfur metabolism_Homo sapiens_hsa009201.54078003
20Galactose metabolism_Homo sapiens_hsa000521.44310646
21Protein export_Homo sapiens_hsa030601.44240914
22Cocaine addiction_Homo sapiens_hsa050301.43893325
23Pancreatic secretion_Homo sapiens_hsa049721.43493113
24Synaptic vesicle cycle_Homo sapiens_hsa047211.36614369
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36423697
26Insulin resistance_Homo sapiens_hsa049311.35133853
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34910445
28Long-term potentiation_Homo sapiens_hsa047201.31765190
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28735863
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.28454781
31Glutamatergic synapse_Homo sapiens_hsa047241.26844664
32Phototransduction_Homo sapiens_hsa047441.25953670
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25936715
34Glucagon signaling pathway_Homo sapiens_hsa049221.24567026
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23706873
36Estrogen signaling pathway_Homo sapiens_hsa049151.19506610
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19357367
38Amphetamine addiction_Homo sapiens_hsa050311.17389023
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15626623
40Steroid biosynthesis_Homo sapiens_hsa001001.14568814
41Selenocompound metabolism_Homo sapiens_hsa004501.12868572
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.11117327
43Dorso-ventral axis formation_Homo sapiens_hsa043201.09083125
44Thyroid hormone synthesis_Homo sapiens_hsa049181.08325486
45Butanoate metabolism_Homo sapiens_hsa006501.08165942
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06683903
47Chronic myeloid leukemia_Homo sapiens_hsa052201.05282961
48Lysosome_Homo sapiens_hsa041421.04968825
49Dopaminergic synapse_Homo sapiens_hsa047281.04378798
50mTOR signaling pathway_Homo sapiens_hsa041501.03735015
51Fatty acid elongation_Homo sapiens_hsa000621.03463279
52Glioma_Homo sapiens_hsa052141.02827550
53Prolactin signaling pathway_Homo sapiens_hsa049171.02081343
54Vibrio cholerae infection_Homo sapiens_hsa051101.01208310
55Inositol phosphate metabolism_Homo sapiens_hsa005620.99562117
56Insulin signaling pathway_Homo sapiens_hsa049100.98450340
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97940989
58VEGF signaling pathway_Homo sapiens_hsa043700.97110493
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.96986209
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95959205
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.93962086
62Endocytosis_Homo sapiens_hsa041440.93037441
63Gastric acid secretion_Homo sapiens_hsa049710.92406347
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91784623
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91720138
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91486532
67Non-small cell lung cancer_Homo sapiens_hsa052230.91442058
68Calcium signaling pathway_Homo sapiens_hsa040200.91352049
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91097576
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90929352
71Fructose and mannose metabolism_Homo sapiens_hsa000510.90530471
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90265920
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90176999
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89332818
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88500417
76Fatty acid metabolism_Homo sapiens_hsa012120.88442963
77Circadian entrainment_Homo sapiens_hsa047130.86266376
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86125444
79Bladder cancer_Homo sapiens_hsa052190.84181722
80B cell receptor signaling pathway_Homo sapiens_hsa046620.83727546
81Type I diabetes mellitus_Homo sapiens_hsa049400.82868865
82Cholinergic synapse_Homo sapiens_hsa047250.76814401
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76337673
84Acute myeloid leukemia_Homo sapiens_hsa052210.74563835
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.74169278
86Gap junction_Homo sapiens_hsa045400.73857523
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73431628
88Sphingolipid metabolism_Homo sapiens_hsa006000.73307267
89Antigen processing and presentation_Homo sapiens_hsa046120.71743806
90Renin secretion_Homo sapiens_hsa049240.70854158
91Long-term depression_Homo sapiens_hsa047300.70570012
92AMPK signaling pathway_Homo sapiens_hsa041520.70307113
93Fat digestion and absorption_Homo sapiens_hsa049750.69555522
94Arginine and proline metabolism_Homo sapiens_hsa003300.68992992
95Circadian rhythm_Homo sapiens_hsa047100.68534218
96Alcoholism_Homo sapiens_hsa050340.68467860
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68032280
98Axon guidance_Homo sapiens_hsa043600.65762467
99Thyroid cancer_Homo sapiens_hsa052160.65120965
100Notch signaling pathway_Homo sapiens_hsa043300.64011834
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63541455
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.63266484
103Olfactory transduction_Homo sapiens_hsa047400.62534832
104Ovarian steroidogenesis_Homo sapiens_hsa049130.61323116
105GnRH signaling pathway_Homo sapiens_hsa049120.61142369
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60101438
107Fatty acid biosynthesis_Homo sapiens_hsa000610.59824553
108Oxytocin signaling pathway_Homo sapiens_hsa049210.59774429
109Protein digestion and absorption_Homo sapiens_hsa049740.58001783
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57987565
111Salivary secretion_Homo sapiens_hsa049700.56282397
112Renal cell carcinoma_Homo sapiens_hsa052110.55966726
113ABC transporters_Homo sapiens_hsa020100.54884301
114T cell receptor signaling pathway_Homo sapiens_hsa046600.54562351
115GABAergic synapse_Homo sapiens_hsa047270.53586612
116ErbB signaling pathway_Homo sapiens_hsa040120.52421268
117Endometrial cancer_Homo sapiens_hsa052130.52209765
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51803473
119Taste transduction_Homo sapiens_hsa047420.51556265
120Serotonergic synapse_Homo sapiens_hsa047260.50074158
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.50030682
122cAMP signaling pathway_Homo sapiens_hsa040240.48965210
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47139919
124Prion diseases_Homo sapiens_hsa050200.46107794
125Bile secretion_Homo sapiens_hsa049760.46032511
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45949428
127beta-Alanine metabolism_Homo sapiens_hsa004100.45817312
128RNA polymerase_Homo sapiens_hsa030200.45585037
129Osteoclast differentiation_Homo sapiens_hsa043800.45419403
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44569003
131Glycerolipid metabolism_Homo sapiens_hsa005610.43773329
132Pancreatic cancer_Homo sapiens_hsa052120.43021133
133Melanogenesis_Homo sapiens_hsa049160.42814892
134Lysine degradation_Homo sapiens_hsa003100.42075133
135Choline metabolism in cancer_Homo sapiens_hsa052310.40702772
136Other glycan degradation_Homo sapiens_hsa005110.40182755
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40000406
138Platelet activation_Homo sapiens_hsa046110.39331322
139Ether lipid metabolism_Homo sapiens_hsa005650.39042786
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34960621
141Oocyte meiosis_Homo sapiens_hsa041140.33461763
142FoxO signaling pathway_Homo sapiens_hsa040680.29755763

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