COG6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.65847264
2fusion of sperm to egg plasma membrane (GO:0007342)6.60571454
3Golgi transport vesicle coating (GO:0048200)5.57288583
4COPI coating of Golgi vesicle (GO:0048205)5.57288583
5sperm motility (GO:0030317)5.23244735
6acrosome assembly (GO:0001675)5.22654463
7plasma membrane fusion (GO:0045026)5.19785943
8piRNA metabolic process (GO:0034587)5.14160427
9multicellular organism reproduction (GO:0032504)5.05939184
10cell wall macromolecule metabolic process (GO:0044036)4.97229430
11cell wall macromolecule catabolic process (GO:0016998)4.97229430
12synapsis (GO:0007129)4.68004859
13acrosome reaction (GO:0007340)4.65745212
14sperm-egg recognition (GO:0035036)4.65178488
15axonemal dynein complex assembly (GO:0070286)4.43180027
16motile cilium assembly (GO:0044458)4.28298894
17reproduction (GO:0000003)4.12066234
18tricarboxylic acid cycle (GO:0006099)4.09970045
19cell-cell recognition (GO:0009988)4.06517664
20male meiosis (GO:0007140)4.05227204
21binding of sperm to zona pellucida (GO:0007339)4.03145869
22epithelial cilium movement (GO:0003351)3.98649333
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.94222809
24carnitine transmembrane transport (GO:1902603)3.93731803
25macroautophagy (GO:0016236)3.89651835
26lactate metabolic process (GO:0006089)3.85808398
27sperm capacitation (GO:0048240)3.84013226
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.80377523
29spermatid development (GO:0007286)3.79560440
30carnitine transport (GO:0015879)3.77238265
31amino-acid betaine transport (GO:0015838)3.77238265
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74955657
33exocrine pancreas development (GO:0031017)3.64115631
34synaptonemal complex organization (GO:0070193)3.63713670
35COPII vesicle coating (GO:0048208)3.62558855
36response to pheromone (GO:0019236)3.61095356
37carnitine shuttle (GO:0006853)3.57761393
38negative regulation of potassium ion transmembrane transport (GO:1901380)3.52364804
39aspartate family amino acid catabolic process (GO:0009068)3.51326992
40protein retention in ER lumen (GO:0006621)3.44873247
41signal peptide processing (GO:0006465)3.43273127
42detection of calcium ion (GO:0005513)3.35875743
43cilium movement (GO:0003341)3.35160047
44chromosome organization involved in meiosis (GO:0070192)3.32973570
45negative regulation of inclusion body assembly (GO:0090084)3.29256980
46protein targeting to Golgi (GO:0000042)3.22430594
47single fertilization (GO:0007338)3.20853188
48establishment of protein localization to Golgi (GO:0072600)3.16266928
49synaptonemal complex assembly (GO:0007130)3.16034353
50regulation of sarcomere organization (GO:0060297)3.15659350
51nonmotile primary cilium assembly (GO:0035058)3.15380430
52calcium ion-dependent exocytosis (GO:0017156)3.13080915
534-hydroxyproline metabolic process (GO:0019471)3.12736613
54righting reflex (GO:0060013)3.12646357
55lysine metabolic process (GO:0006553)3.11880413
56lysine catabolic process (GO:0006554)3.11880413
57quaternary ammonium group transport (GO:0015697)3.11826330
58fatty acid transmembrane transport (GO:1902001)3.11135422
59DNA methylation involved in gamete generation (GO:0043046)3.10997466
60sarcoplasmic reticulum calcium ion transport (GO:0070296)3.10913302
61lipid particle organization (GO:0034389)3.09519884
62sarcomere organization (GO:0045214)3.08843409
63organic cation transport (GO:0015695)3.05784936
64retrograde transport, vesicle recycling within Golgi (GO:0000301)3.05251149
65regulation of type B pancreatic cell apoptotic process (GO:2000674)3.04499020
66positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.02995541
67regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.02527713
68regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.02260872
69activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.98584968
70positive regulation of glycolytic process (GO:0045821)2.95429722
71photoreceptor cell maintenance (GO:0045494)2.95320724
72protein localization to cilium (GO:0061512)2.93978645
73positive regulation of mitochondrial fission (GO:0090141)2.90153231
74negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.86898230
75regulation of skeletal muscle contraction (GO:0014819)2.85564566
76cellular ketone body metabolic process (GO:0046950)2.85145205
77vesicle coating (GO:0006901)2.84009851
78intraciliary transport (GO:0042073)2.82598678
79regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80484477
80regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.78269746
81regulation of acyl-CoA biosynthetic process (GO:0050812)2.76807215
82regulation of meiosis I (GO:0060631)2.76014126
83positive regulation of nuclease activity (GO:0032075)2.75388142
84endocrine pancreas development (GO:0031018)2.74801767
85regulation of cilium movement (GO:0003352)2.74424229
86male meiosis I (GO:0007141)2.73867863
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.73189430
88cilium morphogenesis (GO:0060271)2.72724006
89cardiac muscle contraction (GO:0060048)2.72719759
90cardiac myofibril assembly (GO:0055003)2.70784426
91protein localization to Golgi apparatus (GO:0034067)2.70672598
92* intra-Golgi vesicle-mediated transport (GO:0006891)2.70554030
93ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.69677333
94regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69627146
95UDP-N-acetylglucosamine metabolic process (GO:0006047)2.69029825
96fertilization (GO:0009566)2.68605779
97vascular smooth muscle contraction (GO:0014829)2.67009589
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64901814
99intestinal cholesterol absorption (GO:0030299)2.62676871
100fatty acid beta-oxidation (GO:0006635)2.62155254
101positive regulation of meiosis (GO:0045836)2.61854606
102regulation of cofactor metabolic process (GO:0051193)2.60449155
103regulation of coenzyme metabolic process (GO:0051196)2.60449155
104reflex (GO:0060004)2.60172551
105meiosis I (GO:0007127)2.58106538
106muscle filament sliding (GO:0030049)2.57764175
107actin-myosin filament sliding (GO:0033275)2.57764175
108relaxation of cardiac muscle (GO:0055119)2.57372611
109fatty acid elongation (GO:0030497)2.56667942
110membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56514307
111negative regulation of keratinocyte proliferation (GO:0010839)2.55028758
112cellular response to unfolded protein (GO:0034620)2.54944564
113branched-chain amino acid catabolic process (GO:0009083)2.53988174
114genitalia morphogenesis (GO:0035112)2.53694495
115regulation of sulfur metabolic process (GO:0042762)2.53019402
116valine metabolic process (GO:0006573)2.52732794
117endoplasmic reticulum unfolded protein response (GO:0030968)2.52143215
118cell redox homeostasis (GO:0045454)2.51848647
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.51358432
120tricarboxylic acid metabolic process (GO:0072350)2.50228997
121brain morphogenesis (GO:0048854)2.50094940
122glycogen catabolic process (GO:0005980)2.49955915
1232-oxoglutarate metabolic process (GO:0006103)2.49367317
124pyrimidine ribonucleoside catabolic process (GO:0046133)2.48768644
125succinate metabolic process (GO:0006105)2.48340607
126regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.45674625
127ketone body metabolic process (GO:1902224)2.45494932
128myofibril assembly (GO:0030239)2.45442911
129peptidyl-cysteine modification (GO:0018198)2.45276068
130branched-chain amino acid metabolic process (GO:0009081)2.43870840
131ER to Golgi vesicle-mediated transport (GO:0006888)2.43267462
132regulation of DNA endoreduplication (GO:0032875)2.42249877
133positive regulation of meiotic cell cycle (GO:0051446)2.40595837
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39952992
135regulation of transforming growth factor beta2 production (GO:0032909)2.39513886
136Golgi to endosome transport (GO:0006895)2.38008894
137gene silencing by RNA (GO:0031047)2.36348804
138regulation of establishment of cell polarity (GO:2000114)2.35155269
139positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.32938328
140pancreas development (GO:0031016)2.32516362
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.31126436
142histone H2A acetylation (GO:0043968)2.30683395
143establishment of nucleus localization (GO:0040023)2.25370495
144resolution of meiotic recombination intermediates (GO:0000712)2.25173763
145proline transport (GO:0015824)2.24794973
146peroxisome fission (GO:0016559)2.23674313
147meiotic nuclear division (GO:0007126)2.22543693
148cilium assembly (GO:0042384)2.22193057
149embryonic foregut morphogenesis (GO:0048617)2.21130885
150negative regulation of hormone biosynthetic process (GO:0032353)2.20032970
151cilium organization (GO:0044782)2.19304061
152negative regulation of protein localization to cell surface (GO:2000009)2.18894505
153estrogen biosynthetic process (GO:0006703)2.18568939
154sex differentiation (GO:0007548)2.17939985
155behavioral response to ethanol (GO:0048149)2.16925701
156regulation of integrin-mediated signaling pathway (GO:2001044)2.16321409
157meiotic cell cycle process (GO:1903046)2.16037876
158prenylation (GO:0097354)2.15979337
159protein prenylation (GO:0018342)2.15979337
160sister chromatid cohesion (GO:0007062)2.12726384
161monoubiquitinated protein deubiquitination (GO:0035520)2.11897157
162melanosome transport (GO:0032402)2.11514631
163ADP metabolic process (GO:0046031)2.10879228
164protein K11-linked deubiquitination (GO:0035871)2.08682087
165detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.08097628
166pigment granule transport (GO:0051904)2.07951633
167water-soluble vitamin biosynthetic process (GO:0042364)2.07356813
168retinal rod cell development (GO:0046548)2.07354120
169Golgi to plasma membrane protein transport (GO:0043001)2.06930423
170somite rostral/caudal axis specification (GO:0032525)2.06752979
171establishment of melanosome localization (GO:0032401)2.06733728
172cellular component assembly involved in morphogenesis (GO:0010927)2.04362497
173establishment of pigment granule localization (GO:0051905)2.03533508
174mitotic sister chromatid cohesion (GO:0007064)2.02714375
175microtubule anchoring (GO:0034453)2.02416209
176keratinocyte development (GO:0003334)2.02231714
177DNA synthesis involved in DNA repair (GO:0000731)2.02216133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.22162442
2EZH2_22144423_ChIP-Seq_EOC_Human3.50082255
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91061881
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88325819
5IGF1R_20145208_ChIP-Seq_DFB_Human2.85225718
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.78247084
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.75556837
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73219139
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.65032365
10FUS_26573619_Chip-Seq_HEK293_Human2.47333647
11ZNF274_21170338_ChIP-Seq_K562_Hela2.37156929
12* P300_19829295_ChIP-Seq_ESCs_Human2.14753624
13ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.90770536
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85763681
15EWS_26573619_Chip-Seq_HEK293_Human1.79707301
16VDR_22108803_ChIP-Seq_LS180_Human1.74197649
17* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72211602
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70599977
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68354440
20ER_23166858_ChIP-Seq_MCF-7_Human1.64961444
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.64112202
22GATA1_22025678_ChIP-Seq_K562_Human1.58838862
23* EP300_21415370_ChIP-Seq_HL-1_Mouse1.58559558
24BCAT_22108803_ChIP-Seq_LS180_Human1.56287825
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49122131
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46516583
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.46388958
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42506015
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41128828
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.39908556
31GBX2_23144817_ChIP-Seq_PC3_Human1.39823096
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39605659
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39605659
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39015414
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37077754
36REST_21632747_ChIP-Seq_MESCs_Mouse1.33769678
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.33490958
38ELK1_19687146_ChIP-ChIP_HELA_Human1.32181304
39* TBX20_22328084_ChIP-Seq_HEART_Mouse1.31729201
40* TBX20_22080862_ChIP-Seq_HEART_Mouse1.31729201
41RUNX2_22187159_ChIP-Seq_PCA_Human1.31530040
42CBP_20019798_ChIP-Seq_JUKART_Human1.31300405
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31300405
44TP53_18474530_ChIP-ChIP_U2OS_Human1.30914055
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.30667404
46KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29204231
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26920197
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25887333
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22533383
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22251873
51SMAD4_21799915_ChIP-Seq_A2780_Human1.21421843
52KDM2B_26808549_Chip-Seq_REH_Human1.20738876
53* CMYC_18555785_Chip-Seq_ESCs_Mouse1.20631374
54* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19947036
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19826497
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19552993
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19273787
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18953942
59TCF4_23295773_ChIP-Seq_U87_Human1.18451740
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18005218
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17626721
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17400554
63TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17224611
64CJUN_26792858_Chip-Seq_BT549_Human1.16669109
65DROSHA_22980978_ChIP-Seq_HELA_Human1.16636757
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16549497
67* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16425999
68* STAT3_18555785_Chip-Seq_ESCs_Mouse1.16003805
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.15474620
70ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14442201
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13369439
72P300_18555785_Chip-Seq_ESCs_Mouse1.13014396
73BRD4_25478319_ChIP-Seq_HGPS_Human1.12811833
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12478446
75RNF2_27304074_Chip-Seq_NSC_Mouse1.12255124
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.11104545
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10895237
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10261261
79FLI1_27457419_Chip-Seq_LIVER_Mouse1.09844773
80* STAT3_23295773_ChIP-Seq_U87_Human1.08946168
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08881179
82TAF15_26573619_Chip-Seq_HEK293_Human1.08624318
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.08064162
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07938401
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.07897003
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07469394
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.06779634
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06567331
89AHR_22903824_ChIP-Seq_MCF-7_Human1.06270617
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.06042960
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.05940266
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05623256
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05034864
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04901302
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.04711921
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04646693
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.03397244
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03112132
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02564274
100FOXA2_19822575_ChIP-Seq_HepG2_Human1.01743800
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01513172
102JUN_21703547_ChIP-Seq_K562_Human1.01443017
103TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00940987
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00733387
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.00364685
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99976325
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99805595
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99551829
109PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98123016
110STAT1_17558387_ChIP-Seq_HELA_Human0.97626088
111REST_18959480_ChIP-ChIP_MESCs_Mouse0.96162618
112MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94941523
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94509615
114CBP_21632823_ChIP-Seq_H3396_Human0.93232132
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92984790
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92948376
117GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.92839442
118CRX_20693478_ChIP-Seq_RETINA_Mouse0.92760623
119* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92713720
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.92567857
121AR_25329375_ChIP-Seq_VCAP_Human0.91901998
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90689381
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90389976
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90225684
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90140997
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89872985
127ERG_20517297_ChIP-Seq_VCAP_Human0.89606302
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89403077
129CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89379411
130NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89092160
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.89048774
132LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.88821968
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88503643
134* NANOG_18555785_Chip-Seq_ESCs_Mouse0.87530001
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87321762
136HTT_18923047_ChIP-ChIP_STHdh_Human0.86611948
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86203658
138OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85695983
139P53_22387025_ChIP-Seq_ESCs_Mouse0.85550313
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85358589
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84887934
142WDR5_24793694_ChIP-Seq_LNCAP_Human0.84589401
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.84266064
144* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83599849
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.82853364
146CDX2_22108803_ChIP-Seq_LS180_Human0.82219630
147* TCF4_22108803_ChIP-Seq_LS180_Human0.81377805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.01976101
2MP0002837_dystrophic_cardiac_calcinosis4.05292310
3MP0002909_abnormal_adrenal_gland3.11114885
4MP0003646_muscle_fatigue3.01572894
5MP0009780_abnormal_chondrocyte_physiolo2.81871781
6MP0000751_myopathy2.81637581
7MP0006054_spinal_hemorrhage2.81192767
8MP0004036_abnormal_muscle_relaxation2.79685003
9MP0005670_abnormal_white_adipose2.75924014
10MP0005365_abnormal_bile_salt2.74055868
11MP0004145_abnormal_muscle_electrophysio2.69639157
12MP0000013_abnormal_adipose_tissue2.67742809
13MP0004084_abnormal_cardiac_muscle2.65465163
14MP0004043_abnormal_pH_regulation2.58458020
15MP0000749_muscle_degeneration2.53142048
16MP0000569_abnormal_digit_pigmentation2.45231377
17MP0010234_abnormal_vibrissa_follicle2.43984060
18MP0004215_abnormal_myocardial_fiber2.41866156
19MP0004233_abnormal_muscle_weight2.29008844
20MP0004130_abnormal_muscle_cell2.20550505
21MP0010368_abnormal_lymphatic_system2.12214996
22MP0001666_abnormal_nutrient_absorption2.10274262
23MP0008438_abnormal_cutaneous_collagen2.09334159
24MP0003941_abnormal_skin_development2.06345009
25MP0002693_abnormal_pancreas_physiology2.03710004
26MP0003698_abnormal_male_reproductive2.02797802
27MP0003950_abnormal_plasma_membrane1.94811244
28MP0002139_abnormal_hepatobiliary_system1.90894938
29MP0003868_abnormal_feces_composition1.86124821
30MP0003195_calcinosis1.82977198
31MP0002269_muscular_atrophy1.78334662
32MP0005083_abnormal_biliary_tract1.77155468
33MP0004272_abnormal_basement_membrane1.74772065
34MP0002078_abnormal_glucose_homeostasis1.74203206
35MP0001944_abnormal_pancreas_morphology1.72210240
36MP0003183_abnormal_peptide_metabolism1.71907249
37MP0000427_abnormal_hair_cycle1.71037860
38MP0005620_abnormal_muscle_contractility1.69840544
39MP0008057_abnormal_DNA_replication1.68778855
40MP0001929_abnormal_gametogenesis1.67294219
41MP0010678_abnormal_skin_adnexa1.65302021
42MP0005085_abnormal_gallbladder_physiolo1.63260420
43MP0003283_abnormal_digestive_organ1.62136207
44MP0003890_abnormal_embryonic-extraembry1.60423495
45MP0000747_muscle_weakness1.59255296
46MP0004087_abnormal_muscle_fiber1.57083843
47MP0009046_muscle_twitch1.56098299
48MP0005275_abnormal_skin_tensile1.54442537
49MP0006036_abnormal_mitochondrial_physio1.53551614
50MP0005220_abnormal_exocrine_pancreas1.52752361
51MP0001765_abnormal_ion_homeostasis1.49930524
52MP0002234_abnormal_pharynx_morphology1.49115352
53MP0002160_abnormal_reproductive_system1.48206928
54MP0006276_abnormal_autonomic_nervous1.46033116
55MP0002972_abnormal_cardiac_muscle1.43875307
56MP0005330_cardiomyopathy1.42100010
57MP0002877_abnormal_melanocyte_morpholog1.41328914
58MP0005646_abnormal_pituitary_gland1.38911108
59MP0002106_abnormal_muscle_physiology1.38393018
60MP0003787_abnormal_imprinting1.38092969
61MP0008058_abnormal_DNA_repair1.36184156
62MP0005666_abnormal_adipose_tissue1.35107667
63MP0000383_abnormal_hair_follicle1.34257598
64MP0003959_abnormal_lean_body1.32444727
65MP0001299_abnormal_eye_distance/1.32285655
66MP0001984_abnormal_olfaction1.31566942
67MP0005535_abnormal_body_temperature1.31470689
68MP0001529_abnormal_vocalization1.29794646
69MP0010352_gastrointestinal_tract_polyps1.27681691
70MP0000759_abnormal_skeletal_muscle1.26187329
71MP0003137_abnormal_impulse_conducting1.24177826
72MP0004147_increased_porphyrin_level1.23730678
73MP0004085_abnormal_heartbeat1.23701688
74MP0003937_abnormal_limbs/digits/tail_de1.23100614
75MP0003718_maternal_effect1.21931107
76MP0008789_abnormal_olfactory_epithelium1.20410728
77MP0003252_abnormal_bile_duct1.19254939
78MP0000003_abnormal_adipose_tissue1.16601846
79MP0005503_abnormal_tendon_morphology1.15185627
80MP0008961_abnormal_basal_metabolism1.14402534
81MP0005369_muscle_phenotype1.13520676
82MP0002118_abnormal_lipid_homeostasis1.12299102
83MP0002638_abnormal_pupillary_reflex1.11968493
84MP0005375_adipose_tissue_phenotype1.11692613
85MP0002736_abnormal_nociception_after1.08903019
86MP0003122_maternal_imprinting1.08780018
87MP0005367_renal/urinary_system_phenotyp1.08033228
88MP0000516_abnormal_urinary_system1.08033228
89MP0003953_abnormal_hormone_level1.07994990
90MP0000639_abnormal_adrenal_gland1.06576503
91MP0005058_abnormal_lysosome_morphology1.05517593
92MP0008877_abnormal_DNA_methylation1.04646017
93MP0001502_abnormal_circadian_rhythm1.04383678
94MP0002102_abnormal_ear_morphology1.03377219
95MP0003385_abnormal_body_wall0.99625451
96MP0005394_taste/olfaction_phenotype0.98962648
97MP0005499_abnormal_olfactory_system0.98962648
98MP0000653_abnormal_sex_gland0.97316701
99MP0002896_abnormal_bone_mineralization0.96503469
100MP0002938_white_spotting0.95705952
101MP0002161_abnormal_fertility/fecundity0.95561810
102MP0009250_abnormal_appendicular_skeleto0.95021372
103MP0004484_altered_response_of0.94853748
104MP0003045_fibrosis0.94051058
105MP0000647_abnormal_sebaceous_gland0.93011892
106MP0010630_abnormal_cardiac_muscle0.92930758
107MP0010329_abnormal_lipoprotein_level0.92247412
108MP0005174_abnormal_tail_pigmentation0.92128423
109MP0001270_distended_abdomen0.91839857
110MP0004134_abnormal_chest_morphology0.91773276
111MP0005332_abnormal_amino_acid0.91392056
112MP0000678_abnormal_parathyroid_gland0.90585965
113MP0002971_abnormal_brown_adipose0.90368350
114MP0003121_genomic_imprinting0.89787818
115MP0001544_abnormal_cardiovascular_syste0.89715545
116MP0005385_cardiovascular_system_phenoty0.89715545
117MP0002210_abnormal_sex_determination0.89367411
118MP0005645_abnormal_hypothalamus_physiol0.88928276
119MP0005248_abnormal_Harderian_gland0.88753055
120MP0002295_abnormal_pulmonary_circulatio0.88231138
121MP0001485_abnormal_pinna_reflex0.87709215
122MP0010386_abnormal_urinary_bladder0.87600500
123MP0005636_abnormal_mineral_homeostasis0.87471447
124MP0001879_abnormal_lymphatic_vessel0.86728971
125MP0002254_reproductive_system_inflammat0.86514289
126MP0003119_abnormal_digestive_system0.85740314
127MP0001661_extended_life_span0.85484239
128MP0005171_absent_coat_pigmentation0.85406331
129MP0005395_other_phenotype0.85192828
130MP0008775_abnormal_heart_ventricle0.85108345
131MP0005379_endocrine/exocrine_gland_phen0.85035138
132MP0000230_abnormal_systemic_arterial0.84344440
133MP0001486_abnormal_startle_reflex0.84054113
134MP0003880_abnormal_central_pattern0.83353753
135MP0002084_abnormal_developmental_patter0.82781471
136MP0006072_abnormal_retinal_apoptosis0.82704411
137MP0009697_abnormal_copulation0.82134618
138MP0005187_abnormal_penis_morphology0.82097616
139MP0009643_abnormal_urine_homeostasis0.81998800
140MP0002233_abnormal_nose_morphology0.80525411
141MP0001664_abnormal_digestion0.80426554
142MP0005448_abnormal_energy_balance0.80155004
143MP0002557_abnormal_social/conspecific_i0.79691174
144MP0005551_abnormal_eye_electrophysiolog0.79525470
145MP0006138_congestive_heart_failure0.79033162
146MP0001968_abnormal_touch/_nociception0.77148043
147MP0005334_abnormal_fat_pad0.77019705
148MP0009384_cardiac_valve_regurgitation0.76913013
149MP0001145_abnormal_male_reproductive0.74933300
150MP0003943_abnormal_hepatobiliary_system0.74641282
151MP0005389_reproductive_system_phenotype0.74095171
152MP0004924_abnormal_behavior0.72741252
153MP0005386_behavior/neurological_phenoty0.72741252
154MP0002272_abnormal_nervous_system0.72543313
155MP0005360_urolithiasis0.72359847
156MP0002734_abnormal_mechanical_nocicepti0.71710941
157MP0005623_abnormal_meninges_morphology0.71502925
158MP0008875_abnormal_xenobiotic_pharmacok0.71293306
159MP0004270_analgesia0.71189011
160MP0001756_abnormal_urination0.71150959
161MP0003221_abnormal_cardiomyocyte_apopto0.71114219
162MP0003279_aneurysm0.70683294
163MP0004264_abnormal_extraembryonic_tissu0.70554402
164MP0002184_abnormal_innervation0.70423285
165MP0004142_abnormal_muscle_tone0.70063180
166MP0000750_abnormal_muscle_regeneration0.69771559
167MP0005253_abnormal_eye_physiology0.69695976
168MP0001986_abnormal_taste_sensitivity0.69172483

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.96441989
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.54638313
3Absent/shortened dynein arms (HP:0200106)5.54638313
4Exercise-induced myalgia (HP:0003738)4.55872370
5Hyperinsulinemic hypoglycemia (HP:0000825)4.55594993
6Myoglobinuria (HP:0002913)4.13484045
7Chronic bronchitis (HP:0004469)4.08830898
8Hypoglycemic coma (HP:0001325)3.92142343
9Abnormal respiratory motile cilium physiology (HP:0012261)3.87862935
10Exercise-induced muscle cramps (HP:0003710)3.69349361
11Rhinitis (HP:0012384)3.66609865
12Ketoacidosis (HP:0001993)3.66108902
13Abnormal respiratory epithelium morphology (HP:0012253)3.55235567
14Abnormal respiratory motile cilium morphology (HP:0005938)3.55235567
15Congenital primary aphakia (HP:0007707)3.55147998
16Genetic anticipation (HP:0003743)3.52673629
17Gait imbalance (HP:0002141)3.43446587
18Insulin-resistant diabetes mellitus (HP:0000831)3.37290863
19Hypoglycemic seizures (HP:0002173)3.35520743
20Calf muscle hypertrophy (HP:0008981)3.22667330
21Gaze-evoked nystagmus (HP:0000640)3.20337820
22Muscle hypertrophy of the lower extremities (HP:0008968)3.17904452
23Nephrogenic diabetes insipidus (HP:0009806)3.04536640
24Genital tract atresia (HP:0001827)2.98160160
25Hyperglycemia (HP:0003074)2.97027496
26Ketosis (HP:0001946)2.96894931
27Sudden death (HP:0001699)2.94726539
28Vaginal atresia (HP:0000148)2.93683955
29Large for gestational age (HP:0001520)2.90936511
30Abnormal ciliary motility (HP:0012262)2.87139302
31Symptomatic seizures (HP:0011145)2.82609581
32Asymmetric septal hypertrophy (HP:0001670)2.81959416
33Infertility (HP:0000789)2.81930603
34Progressive cerebellar ataxia (HP:0002073)2.80170652
35Poor coordination (HP:0002370)2.79544003
36Abnormality of the intrinsic pathway (HP:0010989)2.76967585
37Hyporeflexia of lower limbs (HP:0002600)2.74801448
38Gonadotropin excess (HP:0000837)2.61195674
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54963517
40Hypoplastic ischia (HP:0003175)2.52504784
41Methylmalonic acidemia (HP:0002912)2.50842342
42Abnormality of the calf musculature (HP:0001430)2.49115746
43Bundle branch block (HP:0011710)2.47873219
44Rhabdomyolysis (HP:0003201)2.47207313
45Aplasia/Hypoplasia of the lens (HP:0008063)2.43205147
46Action tremor (HP:0002345)2.40803463
47Subaortic stenosis (HP:0001682)2.39843626
48Abnormality of the left ventricular outflow tract (HP:0011103)2.39843626
49Pheochromocytoma (HP:0002666)2.38977688
50Prolonged QT interval (HP:0001657)2.35335028
51Pancreatic islet-cell hyperplasia (HP:0004510)2.35325407
52Gout (HP:0001997)2.33488831
53Muscle fiber splitting (HP:0003555)2.32435941
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.30246117
55Palpitations (HP:0001962)2.29516048
56Abnormality of vitamin B metabolism (HP:0004340)2.28944632
57Abnormality of the ischium (HP:0003174)2.27198777
58Impaired vibratory sensation (HP:0002495)2.26352618
59Abnormality of the pancreatic islet cells (HP:0006476)2.25434495
60Abnormality of endocrine pancreas physiology (HP:0012093)2.25434495
61Difficulty running (HP:0009046)2.24681849
62Abnormality of the renal cortex (HP:0011035)2.24673864
63Intestinal atresia (HP:0011100)2.24405720
64Hyperkalemia (HP:0002153)2.23229543
65Syncope (HP:0001279)2.23101368
66Thyroid carcinoma (HP:0002890)2.21908061
67Atrial fibrillation (HP:0005110)2.20992410
68* Proximal tubulopathy (HP:0000114)2.19361084
69Neuroendocrine neoplasm (HP:0100634)2.18991046
70Central scotoma (HP:0000603)2.15659040
71Late onset (HP:0003584)2.13578136
72Pancreatic fibrosis (HP:0100732)2.13353092
73Nasal polyposis (HP:0100582)2.12871581
74Ventricular tachycardia (HP:0004756)2.10780541
75Left ventricular hypertrophy (HP:0001712)2.10287626
76Dilated cardiomyopathy (HP:0001644)2.09044984
77Tubulointerstitial nephritis (HP:0001970)2.08048439
78Popliteal pterygium (HP:0009756)2.08022655
79Generalized aminoaciduria (HP:0002909)2.07417774
80Protuberant abdomen (HP:0001538)2.05686139
81Bifid tongue (HP:0010297)2.04284963
82Abnormality of macular pigmentation (HP:0008002)2.03551876
83Primary atrial arrhythmia (HP:0001692)2.02974924
84Nephronophthisis (HP:0000090)2.01407588
85Short foot (HP:0001773)2.00917019
86EMG: myopathic abnormalities (HP:0003458)2.00760748
87Dysdiadochokinesis (HP:0002075)1.98993791
88Hypoalphalipoproteinemia (HP:0003233)1.98021228
89Atonic seizures (HP:0010819)1.98017673
90Difficulty climbing stairs (HP:0003551)1.97675123
91Retinal atrophy (HP:0001105)1.96371743
92Volvulus (HP:0002580)1.94936437
93Hypoplasia of the iris (HP:0007676)1.93958690
94Type II lissencephaly (HP:0007260)1.93601222
95Disproportionate short-trunk short stature (HP:0003521)1.93546462
96Bronchitis (HP:0012387)1.92162002
97Lipoatrophy (HP:0100578)1.90642342
98Short tibia (HP:0005736)1.90560261
99Hyperventilation (HP:0002883)1.89709049
100True hermaphroditism (HP:0010459)1.89611078
101Occipital encephalocele (HP:0002085)1.89296120
102Tetraparesis (HP:0002273)1.89227908
103Medial flaring of the eyebrow (HP:0010747)1.88944168
104Insulin resistance (HP:0000855)1.88208148
105Oligodactyly (hands) (HP:0001180)1.87716951
106Broad foot (HP:0001769)1.86630146
107Pancreatic cysts (HP:0001737)1.86336195
108Supraventricular tachycardia (HP:0004755)1.85473942
109Dysmetric saccades (HP:0000641)1.85018111
110Right ventricular cardiomyopathy (HP:0011663)1.83804841
111Abnormality of the nasal mucosa (HP:0000433)1.83770438
112Amyotrophic lateral sclerosis (HP:0007354)1.82804367
113Muscle stiffness (HP:0003552)1.81293484
114Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81260899
115Dicarboxylic aciduria (HP:0003215)1.81260899
116Follicular hyperkeratosis (HP:0007502)1.80750012
117Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79851549
118Ventricular arrhythmia (HP:0004308)1.79400330
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.79295826
120Supraventricular arrhythmia (HP:0005115)1.78707581
121Specific learning disability (HP:0001328)1.78476900
122Hyperglycinemia (HP:0002154)1.77540327
123Postural tremor (HP:0002174)1.77157666
124Decreased testicular size (HP:0008734)1.77032363
125Polyphagia (HP:0002591)1.77005398
126Abnormal EKG (HP:0003115)1.76951619
127Hypoplastic labia majora (HP:0000059)1.76938721
128Ulnar deviation of the wrist (HP:0003049)1.76804058
129Ventricular fibrillation (HP:0001663)1.75768517
130Increased purine levels (HP:0004368)1.75521864
131Hyperuricemia (HP:0002149)1.75521864
132Decreased muscle mass (HP:0003199)1.75505182
133Methylmalonic aciduria (HP:0012120)1.74344184
134Supernumerary spleens (HP:0009799)1.72828264
135Muscle fiber inclusion bodies (HP:0100299)1.72443066
136Abnormality of purine metabolism (HP:0004352)1.72194327
137Widely spaced teeth (HP:0000687)1.72129688
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.71380670
139Cerebellar dysplasia (HP:0007033)1.70756982
140Oligomenorrhea (HP:0000876)1.70319552
141Abnormality of the renal medulla (HP:0100957)1.70039269
142Bronchiectasis (HP:0002110)1.68993200
143Prominent nasal bridge (HP:0000426)1.68507302
144Abnormality of vitamin metabolism (HP:0100508)1.68165990
145Abnormal drinking behavior (HP:0030082)1.65906248
146Polydipsia (HP:0001959)1.65906248
147Tubulointerstitial abnormality (HP:0001969)1.64925169
148Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.64415185
149Abnormality of fatty-acid metabolism (HP:0004359)1.64103676
150Delayed gross motor development (HP:0002194)1.63736016
151Fair hair (HP:0002286)1.63714036
152Gowers sign (HP:0003391)1.63596291
153Renal cortical cysts (HP:0000803)1.63101970
154Papillary thyroid carcinoma (HP:0002895)1.61697416
155Abnormality of the lower motor neuron (HP:0002366)1.61686070
156Rimmed vacuoles (HP:0003805)1.61462997
157Congenital sensorineural hearing impairment (HP:0008527)1.61187098
158Abnormality of the labia (HP:0000058)1.60278781
159Hypoplasia of the fovea (HP:0007750)1.59100145
160Aplasia/Hypoplasia of the fovea (HP:0008060)1.59100145
161Astigmatism (HP:0000483)1.58896803
162Labial hypoplasia (HP:0000066)1.58610481
163Chorioretinal atrophy (HP:0000533)1.58337763
164Type I transferrin isoform profile (HP:0003642)1.58215251
165Drooling (HP:0002307)1.57892469
166Menstrual irregularities (HP:0000858)1.57625499
167Spontaneous abortion (HP:0005268)1.57453433
168Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.57302176
169Hypoplastic iliac wings (HP:0002866)1.57047801
170Postaxial hand polydactyly (HP:0001162)1.56708803
171Hypothermia (HP:0002045)1.56086155
172Absence seizures (HP:0002121)1.55122135
173Absent speech (HP:0001344)1.52953582
174Facial diplegia (HP:0001349)1.52921149
175Dental crowding (HP:0000678)1.52629981
176Abnormality of the labia majora (HP:0012881)1.52592806
177Rhabdomyosarcoma (HP:0002859)1.52474559
178Hemiparesis (HP:0001269)1.52373913
179Abnormality of the astrocytes (HP:0100707)1.51059109
180Astrocytoma (HP:0009592)1.51059109
181Scotoma (HP:0000575)1.51016318
182Abnormality of dentin (HP:0010299)1.49761271
183Retinal dysplasia (HP:0007973)1.49448499
184Horizontal nystagmus (HP:0000666)1.48294785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.63129234
2PDK36.63129234
3PDK24.25705878
4BCKDK3.28530738
5PRKD33.20749901
6INSRR3.18137152
7PNCK2.70037322
8WNK42.68971894
9BCR2.46562934
10LMTK22.40125205
11OXSR12.31511970
12PHKG12.29095208
13PHKG22.29095208
14FRK2.27388515
15MST42.21105034
16ACVR1B2.13101018
17OBSCN2.10836069
18MAP4K21.98665787
19EIF2AK31.95678563
20PLK21.95065361
21TTN1.93584900
22MAP3K91.92935462
23CASK1.86916869
24MET1.80332185
25TNIK1.80322707
26PIK3CG1.77062691
27PASK1.77041402
28WNK31.72796958
29MAP3K121.68783543
30BMPR1B1.65192695
31TRIM281.63895805
32ERN11.61995106
33ERBB31.59253511
34CSNK1G11.52011574
35TESK11.44014637
36MAPK151.40366697
37TRIB31.38687391
38CDK191.37328479
39FGFR21.29539493
40CSNK1G21.29047152
41MAP3K41.28080936
42CSNK1G31.27022391
43GRK11.24666652
44FLT31.23602780
45MAP3K21.19572203
46PINK11.08455035
47CSNK1A1L1.08430189
48STK391.07100613
49WNK11.06045775
50PTK2B1.05460538
51TSSK61.00278040
52PIK3CA0.98964801
53STK380.97572337
54NEK10.97478568
55PRKAA10.97227728
56RIPK10.94915253
57MAP3K30.93667962
58PTK60.93040111
59BRD40.92352898
60AKT30.92326706
61PLK40.90961484
62PLK30.89127176
63MUSK0.88914966
64IRAK10.88395456
65BRSK20.87335864
66ICK0.86790529
67NLK0.86487332
68PAK30.86228201
69EPHA40.84989294
70SIK10.83919052
71NUAK10.83849397
72EIF2AK10.82874342
73MAP2K40.82124722
74PKN20.81548388
75CAMK1G0.80021815
76TAOK30.79615487
77ZAK0.76356675
78MAPKAPK30.75330938
79LIMK10.75144405
80PDK10.72828870
81PRKCH0.72697616
82PDGFRA0.72478666
83CDC42BPA0.72067826
84PBK0.71404060
85FGFR10.71234924
86TTK0.69556183
87STK38L0.67462829
88PRKAA20.64848202
89TRPM70.64173047
90MAP3K70.63324054
91LATS10.63153795
92TAF10.61901823
93MINK10.60847648
94PLK10.57409756
95YES10.56570885
96SCYL20.56377322
97NEK90.54823246
98FER0.54619270
99PRKCG0.54102068
100DYRK1B0.53409190
101MKNK20.52515937
102MAP3K50.52445075
103WEE10.52274266
104HIPK20.52044287
105STK240.50978314
106CAMK1D0.50847942
107MAP2K70.50610811
108RET0.49194501
109MAPK130.48868837
110MAP2K60.48822365
111CAMK2D0.47899305
112MAP2K10.46399208
113MAPK120.45908638
114RPS6KB10.45850551
115DMPK0.44898748
116TAOK20.44424950
117CAMKK20.44132217
118PRKCE0.44018037
119PRKACG0.43604785
120MST1R0.43183476
121MYLK0.42754472
122KSR10.42293218
123ROCK10.42150312
124ATM0.41433975
125EGFR0.40687489
126PRKD10.40313336
127MKNK10.39843805
128CAMK2A0.37861542
129NTRK30.37745909
130ERBB20.36803341
131PDPK10.36465410
132IRAK20.36322843
133CSNK1E0.36090088
134MAP3K10.34921723
135ADRBK10.34006035
136TIE10.33602499
137TGFBR10.32892946
138MAP2K20.32844388
139CSNK1D0.32626250
140PRKG10.32577659
141MAP2K30.31195404
142STK30.30766123
143CAMK10.29807215
144CAMKK10.29531418
145TGFBR20.29260418
146MTOR0.29035626
147PRKACA0.27848014
148DDR20.27760596
149PRKACB0.27480610
150SGK30.25244127
151IGF1R0.25200443
152SGK2230.24775921
153SGK4940.24775921
154PTK20.23597252
155EPHA30.21651098
156MAPK110.21341371
157GRK70.20940716
158PDGFRB0.20560209
159EEF2K0.19316011
160RPS6KA30.18792286
161CCNB10.18234434

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.23094930
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.76704215
3Propanoate metabolism_Homo sapiens_hsa006403.60652552
4Pyruvate metabolism_Homo sapiens_hsa006202.73117628
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53979842
6Fatty acid degradation_Homo sapiens_hsa000712.50382370
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.28468132
8Insulin secretion_Homo sapiens_hsa049112.19195243
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12850703
10Fatty acid metabolism_Homo sapiens_hsa012122.08770960
11Sulfur metabolism_Homo sapiens_hsa009202.05099810
12Glucagon signaling pathway_Homo sapiens_hsa049221.96811017
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.88784139
14Protein export_Homo sapiens_hsa030601.75817514
15Pancreatic secretion_Homo sapiens_hsa049721.66143485
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61835958
17Carbon metabolism_Homo sapiens_hsa012001.59374074
18Selenocompound metabolism_Homo sapiens_hsa004501.59267954
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58915615
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50025452
21Steroid biosynthesis_Homo sapiens_hsa001001.42674852
22Starch and sucrose metabolism_Homo sapiens_hsa005001.42525655
23Fatty acid biosynthesis_Homo sapiens_hsa000611.41761100
24ABC transporters_Homo sapiens_hsa020101.40530659
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.40357053
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37374239
27Cardiac muscle contraction_Homo sapiens_hsa042601.34709895
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29922263
29Dilated cardiomyopathy_Homo sapiens_hsa054141.28012078
30Fat digestion and absorption_Homo sapiens_hsa049751.26372077
31PPAR signaling pathway_Homo sapiens_hsa033201.25414963
32Type II diabetes mellitus_Homo sapiens_hsa049301.25173014
33Basal transcription factors_Homo sapiens_hsa030221.20521188
34Butanoate metabolism_Homo sapiens_hsa006501.19391302
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19096909
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18404710
37Tryptophan metabolism_Homo sapiens_hsa003801.17841748
38Glycerolipid metabolism_Homo sapiens_hsa005611.16105935
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15581605
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11085239
41Protein digestion and absorption_Homo sapiens_hsa049741.10820245
42Folate biosynthesis_Homo sapiens_hsa007901.07989277
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07390473
44Sphingolipid metabolism_Homo sapiens_hsa006001.05577120
45Oocyte meiosis_Homo sapiens_hsa041141.05508099
46Fructose and mannose metabolism_Homo sapiens_hsa000511.05461129
47Insulin resistance_Homo sapiens_hsa049311.03074778
48Amphetamine addiction_Homo sapiens_hsa050311.02718047
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02247403
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01272416
51Non-homologous end-joining_Homo sapiens_hsa034501.00627424
52Circadian rhythm_Homo sapiens_hsa047100.99618228
53Adherens junction_Homo sapiens_hsa045200.99517915
54Galactose metabolism_Homo sapiens_hsa000520.97273201
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97202583
56N-Glycan biosynthesis_Homo sapiens_hsa005100.96932531
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96830086
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96475895
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.94109403
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92785721
61Nicotine addiction_Homo sapiens_hsa050330.91492873
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89025626
63Renin secretion_Homo sapiens_hsa049240.87828237
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86839910
65Retinol metabolism_Homo sapiens_hsa008300.86787109
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86075809
67Peroxisome_Homo sapiens_hsa041460.85292448
68Calcium signaling pathway_Homo sapiens_hsa040200.84441687
69Tight junction_Homo sapiens_hsa045300.84352956
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84166343
71TGF-beta signaling pathway_Homo sapiens_hsa043500.83954745
72Cocaine addiction_Homo sapiens_hsa050300.81336460
73Biosynthesis of amino acids_Homo sapiens_hsa012300.79945322
74Dorso-ventral axis formation_Homo sapiens_hsa043200.79636739
75Vibrio cholerae infection_Homo sapiens_hsa051100.79314304
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79100950
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76638993
78Circadian entrainment_Homo sapiens_hsa047130.75252470
79Insulin signaling pathway_Homo sapiens_hsa049100.75232418
80Fatty acid elongation_Homo sapiens_hsa000620.74970463
81Hippo signaling pathway_Homo sapiens_hsa043900.73815854
82ECM-receptor interaction_Homo sapiens_hsa045120.72894744
83Fanconi anemia pathway_Homo sapiens_hsa034600.72338268
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71335458
85Long-term depression_Homo sapiens_hsa047300.70113008
86Bile secretion_Homo sapiens_hsa049760.68068297
87Pentose phosphate pathway_Homo sapiens_hsa000300.67303082
88Phototransduction_Homo sapiens_hsa047440.67075938
89Glutamatergic synapse_Homo sapiens_hsa047240.65692085
90RNA degradation_Homo sapiens_hsa030180.63978792
91Thyroid hormone synthesis_Homo sapiens_hsa049180.63900161
92Serotonergic synapse_Homo sapiens_hsa047260.62988426
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62544024
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.60921587
95Synaptic vesicle cycle_Homo sapiens_hsa047210.60762876
96Hedgehog signaling pathway_Homo sapiens_hsa043400.58872662
97AMPK signaling pathway_Homo sapiens_hsa041520.58840389
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58557168
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58508695
100GABAergic synapse_Homo sapiens_hsa047270.57810005
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56800828
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56496520
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56141569
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55324570
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54694528
106Lysine degradation_Homo sapiens_hsa003100.53218694
107Chemical carcinogenesis_Homo sapiens_hsa052040.52935699
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.52785476
109Metabolic pathways_Homo sapiens_hsa011000.52662466
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51550931
111Nitrogen metabolism_Homo sapiens_hsa009100.51429317
112Other glycan degradation_Homo sapiens_hsa005110.50805981
113Morphine addiction_Homo sapiens_hsa050320.50496758
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.49418236
115Taste transduction_Homo sapiens_hsa047420.49395964
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49073784
117Salivary secretion_Homo sapiens_hsa049700.47922393
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.47617127
119Regulation of autophagy_Homo sapiens_hsa041400.47389868
120Caffeine metabolism_Homo sapiens_hsa002320.47002724
121Vitamin B6 metabolism_Homo sapiens_hsa007500.46490339
122Dopaminergic synapse_Homo sapiens_hsa047280.46473435
123Wnt signaling pathway_Homo sapiens_hsa043100.45834614
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45318328
125Inositol phosphate metabolism_Homo sapiens_hsa005620.45308979
126Oxytocin signaling pathway_Homo sapiens_hsa049210.45297628
127Collecting duct acid secretion_Homo sapiens_hsa049660.44507065
128Long-term potentiation_Homo sapiens_hsa047200.43684933
129cAMP signaling pathway_Homo sapiens_hsa040240.43269786
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41626729
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41317063
132Lysosome_Homo sapiens_hsa041420.41074183
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39070643
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38931539
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37864543
136beta-Alanine metabolism_Homo sapiens_hsa004100.37814891
137Arginine and proline metabolism_Homo sapiens_hsa003300.37238855
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35578848
139Arginine biosynthesis_Homo sapiens_hsa002200.34698468
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34428201
141Estrogen signaling pathway_Homo sapiens_hsa049150.34339427
142Gastric acid secretion_Homo sapiens_hsa049710.33971137

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