COIL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.85955423
2formation of translation preinitiation complex (GO:0001731)4.52176031
3mitotic metaphase plate congression (GO:0007080)4.25598524
4purine nucleobase biosynthetic process (GO:0009113)4.23340776
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19347147
6ATP synthesis coupled proton transport (GO:0015986)4.19347147
7nucleobase biosynthetic process (GO:0046112)4.18705208
8DNA replication-dependent nucleosome assembly (GO:0006335)4.09738219
9DNA replication-dependent nucleosome organization (GO:0034723)4.09738219
10protein localization to kinetochore (GO:0034501)3.90668044
11DNA deamination (GO:0045006)3.90441089
12protein localization to chromosome, centromeric region (GO:0071459)3.89007508
13ribosomal small subunit assembly (GO:0000028)3.86033441
14regulation of mitochondrial translation (GO:0070129)3.84044697
15DNA replication checkpoint (GO:0000076)3.79580215
16binding of sperm to zona pellucida (GO:0007339)3.79140593
17interferon-gamma secretion (GO:0072643)3.79047760
18DNA replication initiation (GO:0006270)3.77593468
19synaptonemal complex assembly (GO:0007130)3.75952874
20folic acid metabolic process (GO:0046655)3.75608650
21ribosome biogenesis (GO:0042254)3.71491188
22protein complex biogenesis (GO:0070271)3.70917899
23sperm-egg recognition (GO:0035036)3.69996119
24ribosome assembly (GO:0042255)3.67789047
25DNA strand elongation involved in DNA replication (GO:0006271)3.67518944
26mitochondrial respiratory chain complex assembly (GO:0033108)3.65510086
27piRNA metabolic process (GO:0034587)3.65154223
28mitotic nuclear envelope disassembly (GO:0007077)3.57389477
29DNA double-strand break processing (GO:0000729)3.55655200
30chaperone-mediated protein transport (GO:0072321)3.55621978
31maturation of SSU-rRNA (GO:0030490)3.54975057
32replication fork processing (GO:0031297)3.53088860
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.52575754
34synaptonemal complex organization (GO:0070193)3.52478788
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.51303078
36NADH dehydrogenase complex assembly (GO:0010257)3.51303078
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51303078
38metaphase plate congression (GO:0051310)3.50616133
39DNA strand elongation (GO:0022616)3.48568537
40establishment of integrated proviral latency (GO:0075713)3.45258272
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45165437
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43699291
43nuclear pore organization (GO:0006999)3.41703478
44inner mitochondrial membrane organization (GO:0007007)3.41142359
45microtubule depolymerization (GO:0007019)3.40963020
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40037442
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37644943
48membrane disassembly (GO:0030397)3.34738872
49nuclear envelope disassembly (GO:0051081)3.34738872
50mitotic sister chromatid segregation (GO:0000070)3.34526924
51histone exchange (GO:0043486)3.34368639
52sperm motility (GO:0030317)3.34186266
53fusion of sperm to egg plasma membrane (GO:0007342)3.33822072
54protein neddylation (GO:0045116)3.33371757
55chaperone-mediated protein complex assembly (GO:0051131)3.32055818
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31759947
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31045052
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30900053
59ribosomal small subunit biogenesis (GO:0042274)3.30236418
60translational termination (GO:0006415)3.29414512
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28848805
62rRNA modification (GO:0000154)3.28173832
63respiratory electron transport chain (GO:0022904)3.27489555
64viral transcription (GO:0019083)3.26765086
65ribonucleoprotein complex biogenesis (GO:0022613)3.25601822
66chromatin remodeling at centromere (GO:0031055)3.24709042
67electron transport chain (GO:0022900)3.22792231
68telomere maintenance via semi-conservative replication (GO:0032201)3.22243948
69cell-cell recognition (GO:0009988)3.22198427
70nuclear pore complex assembly (GO:0051292)3.20943892
71regulation of centriole replication (GO:0046599)3.20260860
72respiratory chain complex IV assembly (GO:0008535)3.20188300
73spermatid development (GO:0007286)3.18970755
74spliceosomal snRNP assembly (GO:0000387)3.16528500
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16401691
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.16401691
77proteasome assembly (GO:0043248)3.16113350
78regulation of spindle organization (GO:0090224)3.15464787
79regulation of chromosome segregation (GO:0051983)3.14608527
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.14237696
81cullin deneddylation (GO:0010388)3.13553975
82chromosome condensation (GO:0030261)3.13449970
83establishment of chromosome localization (GO:0051303)3.12641659
84negative regulation of chromosome segregation (GO:0051985)3.12395831
85CENP-A containing nucleosome assembly (GO:0034080)3.11223281
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10660040
87cotranslational protein targeting to membrane (GO:0006613)3.10346975
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09005438
89negative regulation of ligase activity (GO:0051352)3.09005438
90DNA replication-independent nucleosome organization (GO:0034724)3.07574136
91DNA replication-independent nucleosome assembly (GO:0006336)3.07574136
92male meiosis (GO:0007140)3.07232579
93regulation of cilium movement (GO:0003352)3.06971020
94cytochrome complex assembly (GO:0017004)3.06065698
95DNA packaging (GO:0006323)3.05689575
96meiotic nuclear division (GO:0007126)3.05480477
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.05013304
98ribosomal large subunit biogenesis (GO:0042273)3.04804354
99regulation of helicase activity (GO:0051095)3.04634368
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.04293002
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04293002
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04293002
103negative regulation of sister chromatid segregation (GO:0033046)3.04293002
104rRNA processing (GO:0006364)3.03984026
105cellular component biogenesis (GO:0044085)3.03765335
106protein targeting to ER (GO:0045047)3.03527509
107regulation of translation in response to stress (GO:0043555)3.02175434
108protein complex localization (GO:0031503)3.02071486
109meiosis I (GO:0007127)3.02043388
110negative regulation of DNA-dependent DNA replication (GO:2000104)3.00971463
111spliceosomal complex assembly (GO:0000245)3.00854949
112regulation of DNA endoreduplication (GO:0032875)3.00704871
113maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98606008
114postreplication repair (GO:0006301)2.98046428
115rRNA metabolic process (GO:0016072)2.97726448
116chromosome organization involved in meiosis (GO:0070192)2.95280822
117telomere maintenance via recombination (GO:0000722)2.94624175
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94509363
119establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94407371
120regulation of centrosome cycle (GO:0046605)2.93437500
121spindle checkpoint (GO:0031577)2.93235079
122male meiosis I (GO:0007141)2.92581131
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92228221
124translation (GO:0006412)2.91741708
125kinetochore organization (GO:0051383)2.91398847
126positive regulation of chromosome segregation (GO:0051984)2.91318955
127protein deneddylation (GO:0000338)2.91179094
128kinetochore assembly (GO:0051382)2.90256708
129regulation of double-strand break repair via homologous recombination (GO:0010569)2.90047304
130pseudouridine synthesis (GO:0001522)2.90001821
131DNA unwinding involved in DNA replication (GO:0006268)2.89980244
132regulation of ubiquitin-protein transferase activity (GO:0051438)2.89575739
133DNA catabolic process, exonucleolytic (GO:0000738)2.88872076
134mitotic spindle assembly checkpoint (GO:0007094)2.88765384
135histone mRNA metabolic process (GO:0008334)2.88371766
136DNA damage response, detection of DNA damage (GO:0042769)2.87496745
137translational initiation (GO:0006413)2.87106545
138establishment of protein localization to mitochondrial membrane (GO:0090151)2.87071163
139spindle assembly checkpoint (GO:0071173)2.87046660
140resolution of meiotic recombination intermediates (GO:0000712)2.86953944
141viral mRNA export from host cell nucleus (GO:0046784)2.86618111
142mitotic recombination (GO:0006312)2.86071393
143histone H2A acetylation (GO:0043968)2.85825978
144cilium or flagellum-dependent cell motility (GO:0001539)2.85536429
145translesion synthesis (GO:0019985)2.84567390
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.84449405
147termination of RNA polymerase III transcription (GO:0006386)2.84449405
148rRNA methylation (GO:0031167)2.84397722
149translational elongation (GO:0006414)2.82780812
150recombinational repair (GO:0000725)2.81293222
151protein localization to endoplasmic reticulum (GO:0070972)2.80927215
152double-strand break repair via homologous recombination (GO:0000724)2.80037454
153DNA ligation (GO:0006266)2.80016261
154termination of RNA polymerase II transcription (GO:0006369)2.77497016
155transcription-coupled nucleotide-excision repair (GO:0006283)2.76599589
156non-recombinational repair (GO:0000726)2.74896345
157double-strand break repair via nonhomologous end joining (GO:0006303)2.74896345
158maturation of 5.8S rRNA (GO:0000460)2.73957702
159nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73323623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52418233
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.62839736
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.00639776
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.57168542
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.11585549
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08887723
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07721696
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00013420
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.89021650
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88857570
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80755816
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75867589
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75566103
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.70003044
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64257221
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.58534014
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53607433
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43440080
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25510783
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.18039034
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16953853
22ZNF274_21170338_ChIP-Seq_K562_Hela2.16680186
23XRN2_22483619_ChIP-Seq_HELA_Human2.15071003
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12032925
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.09170165
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.08108797
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07526730
28* VDR_23849224_ChIP-Seq_CD4+_Human2.03692281
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.99992965
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98688565
31MYC_18940864_ChIP-ChIP_HL60_Human1.98397040
32FUS_26573619_Chip-Seq_HEK293_Human1.98351380
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93055616
34EWS_26573619_Chip-Seq_HEK293_Human1.93034086
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87930530
36AR_21909140_ChIP-Seq_LNCAP_Human1.87831430
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86627181
38GABP_19822575_ChIP-Seq_HepG2_Human1.86494647
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84471535
40DCP1A_22483619_ChIP-Seq_HELA_Human1.79828212
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79583737
42* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78433408
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74767217
44FOXP3_21729870_ChIP-Seq_TREG_Human1.73891440
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67112471
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66897065
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66158187
48TTF2_22483619_ChIP-Seq_HELA_Human1.65804701
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63576102
50* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57405217
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56824197
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52757265
53VDR_22108803_ChIP-Seq_LS180_Human1.52478265
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.52207392
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51426289
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49609087
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46167051
58KDM5A_27292631_Chip-Seq_BREAST_Human1.45521092
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45317657
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43883177
61* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41816787
62CIITA_25753668_ChIP-Seq_RAJI_Human1.39036560
63IRF1_19129219_ChIP-ChIP_H3396_Human1.38942792
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38367567
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.37449065
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36664500
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36563877
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32432413
69* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29688786
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28784361
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27658756
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.26543791
73IGF1R_20145208_ChIP-Seq_DFB_Human1.26496596
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25088764
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25088764
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25088764
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.24233142
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23226713
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21954350
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21698028
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.21604117
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.18758131
83* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15990902
84TAF15_26573619_Chip-Seq_HEK293_Human1.14311474
85NANOG_16153702_ChIP-ChIP_HESCs_Human1.13459525
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13233492
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11650736
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11575439
89* SRF_21415370_ChIP-Seq_HL-1_Mouse1.10892641
90ZNF263_19887448_ChIP-Seq_K562_Human1.10892230
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10718243
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.09219527
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07590267
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07490164
95* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05236044
96* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04337287
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04076152
98ELK1_19687146_ChIP-ChIP_HELA_Human1.03969666
99MYC_22102868_ChIP-Seq_BL_Human1.03569257
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03261894
101* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01748109
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01432961
103TP63_19390658_ChIP-ChIP_HaCaT_Human1.01168522
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99074604
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98416395
106* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98217696
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96997963
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95129617
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94999817
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94849799
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94536709
112TP53_22573176_ChIP-Seq_HFKS_Human0.94338871
113* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93947441
114TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93259203
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93045925
116* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92504947
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92150373
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.91973436
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91652652
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91631287
121* ER_23166858_ChIP-Seq_MCF-7_Human0.91628200
122TFEB_21752829_ChIP-Seq_HELA_Human0.91264537
123P300_19829295_ChIP-Seq_ESCs_Human0.91069508
124CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90539950
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89948420
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89550360
127EGR1_19374776_ChIP-ChIP_THP-1_Human0.89537346
128YY1_22570637_ChIP-Seq_MALME-3M_Human0.89499640
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88644993
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88294539
131KAP1_27257070_Chip-Seq_ESCs_Mouse0.86985200
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86401614
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86211187
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81005273
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.79779833
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78593527
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77168082
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74206793
139TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73491857
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70384405
141CBP_20019798_ChIP-Seq_JUKART_Human0.70203639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.10579925
2MP0004957_abnormal_blastocyst_morpholog4.81673676
3* MP0003111_abnormal_nucleus_morphology4.64677606
4MP0005410_abnormal_fertilization4.36576526
5MP0010094_abnormal_chromosome_stability4.13642624
6MP0003077_abnormal_cell_cycle3.83661833
7MP0008057_abnormal_DNA_replication3.79080403
8MP0008058_abnormal_DNA_repair3.51372858
9MP0008877_abnormal_DNA_methylation3.11072868
10MP0008932_abnormal_embryonic_tissue2.77220236
11MP0001929_abnormal_gametogenesis2.57838808
12MP0001730_embryonic_growth_arrest2.56864663
13MP0009697_abnormal_copulation2.55110211
14MP0008007_abnormal_cellular_replicative2.34315224
15MP0002653_abnormal_ependyma_morphology2.33197853
16MP0003698_abnormal_male_reproductive2.31462958
17MP0009379_abnormal_foot_pigmentation2.26508955
18MP0002210_abnormal_sex_determination2.25862699
19MP0001529_abnormal_vocalization2.17817672
20MP0003123_paternal_imprinting2.13160518
21MP0000350_abnormal_cell_proliferation2.12428408
22MP0002938_white_spotting2.12048846
23MP0003718_maternal_effect2.11973555
24MP0003786_premature_aging2.08707492
25MP0001145_abnormal_male_reproductive2.04843379
26MP0010352_gastrointestinal_tract_polyps1.99370246
27MP0001672_abnormal_embryogenesis/_devel1.96620181
28MP0005380_embryogenesis_phenotype1.96620181
29MP0008995_early_reproductive_senescence1.95689404
30MP0002102_abnormal_ear_morphology1.88284934
31MP0001697_abnormal_embryo_size1.84447914
32MP0008789_abnormal_olfactory_epithelium1.78721340
33MP0002085_abnormal_embryonic_tissue1.72777739
34MP0002084_abnormal_developmental_patter1.72509026
35MP0002080_prenatal_lethality1.70322801
36MP0003984_embryonic_growth_retardation1.67381753
37MP0000653_abnormal_sex_gland1.66334265
38MP0002088_abnormal_embryonic_growth/wei1.63646094
39MP0003806_abnormal_nucleotide_metabolis1.63091223
40MP0003890_abnormal_embryonic-extraembry1.57595646
41MP0003315_abnormal_perineum_morphology1.54598995
42MP0002086_abnormal_extraembryonic_tissu1.52586236
43MP0002161_abnormal_fertility/fecundity1.49734232
44MP0000372_irregular_coat_pigmentation1.47498824
45MP0001346_abnormal_lacrimal_gland1.45814067
46MP0002234_abnormal_pharynx_morphology1.43431887
47MP0002160_abnormal_reproductive_system1.41987039
48MP0003119_abnormal_digestive_system1.41801265
49MP0002396_abnormal_hematopoietic_system1.36646583
50MP0000358_abnormal_cell_content/1.36187819
51MP0000313_abnormal_cell_death1.36095315
52MP0005646_abnormal_pituitary_gland1.34074583
53MP0004197_abnormal_fetal_growth/weight/1.32957514
54MP0004133_heterotaxia1.32702340
55MP0000490_abnormal_crypts_of1.32475836
56MP0001293_anophthalmia1.31920097
57MP0003136_yellow_coat_color1.31570823
58MP0005253_abnormal_eye_physiology1.30802257
59MP0005394_taste/olfaction_phenotype1.27598521
60MP0005499_abnormal_olfactory_system1.27598521
61MP0008260_abnormal_autophagy1.26271159
62MP0000566_synostosis1.24000572
63MP0010307_abnormal_tumor_latency1.23721527
64MP0006292_abnormal_olfactory_placode1.23035829
65MP0003567_abnormal_fetal_cardiomyocyte1.22575364
66MP0003787_abnormal_imprinting1.21444097
67MP0000631_abnormal_neuroendocrine_gland1.20716122
68MP0006035_abnormal_mitochondrial_morpho1.17224755
69MP0003011_delayed_dark_adaptation1.16303251
70MP0002233_abnormal_nose_morphology1.15990045
71MP0005084_abnormal_gallbladder_morpholo1.15416341
72MP0005389_reproductive_system_phenotype1.12126463
73MP0000537_abnormal_urethra_morphology1.10834731
74MP0005391_vision/eye_phenotype1.09434596
75MP0000647_abnormal_sebaceous_gland1.09313572
76MP0002019_abnormal_tumor_incidence1.09183397
77MP0002751_abnormal_autonomic_nervous1.05865433
78MP0000049_abnormal_middle_ear1.04541186
79MP0001764_abnormal_homeostasis1.03161571
80MP0002837_dystrophic_cardiac_calcinosis1.02749846
81MP0001727_abnormal_embryo_implantation0.98178533
82MP0002697_abnormal_eye_size0.97819109
83MP0003122_maternal_imprinting0.97573509
84MP0005551_abnormal_eye_electrophysiolog0.97304934
85MP0004233_abnormal_muscle_weight0.96489829
86MP0002736_abnormal_nociception_after0.95447960
87MP0001545_abnormal_hematopoietic_system0.94672427
88MP0005397_hematopoietic_system_phenotyp0.94672427
89MP0006276_abnormal_autonomic_nervous0.94592774
90MP0005408_hypopigmentation0.90586411
91MP0005379_endocrine/exocrine_gland_phen0.90505026
92MP0009840_abnormal_foam_cell0.90149863
93MP0010030_abnormal_orbit_morphology0.88875635
94MP0004142_abnormal_muscle_tone0.87628240
95MP0002090_abnormal_vision0.87305200
96MP0003880_abnormal_central_pattern0.86409881
97MP0003646_muscle_fatigue0.85921672
98MP0005187_abnormal_penis_morphology0.85033818
99MP0002095_abnormal_skin_pigmentation0.81132769
100MP0002638_abnormal_pupillary_reflex0.80727081
101MP0000427_abnormal_hair_cycle0.80683403
102MP0005377_hearing/vestibular/ear_phenot0.79582009
103MP0003878_abnormal_ear_physiology0.79582009
104MP0002282_abnormal_trachea_morphology0.78432438
105MP0004808_abnormal_hematopoietic_stem0.78075456
106MP0003121_genomic_imprinting0.78044846
107MP0001984_abnormal_olfaction0.77837430
108MP0005384_cellular_phenotype0.77608678
109MP0003861_abnormal_nervous_system0.76931419
110MP0001919_abnormal_reproductive_system0.76867962
111MP0001485_abnormal_pinna_reflex0.75521436
112MP0001188_hyperpigmentation0.75332832
113MP0001849_ear_inflammation0.75121732
114MP0002277_abnormal_respiratory_mucosa0.73966814
115MP0004264_abnormal_extraembryonic_tissu0.73851720
116MP0006036_abnormal_mitochondrial_physio0.72629259
117MP0002111_abnormal_tail_morphology0.70850880
118MP0005075_abnormal_melanosome_morpholog0.70722158
119MP0009672_abnormal_birth_weight0.69666911
120MP0001119_abnormal_female_reproductive0.69611374
121MP0003221_abnormal_cardiomyocyte_apopto0.68626097
122MP0005076_abnormal_cell_differentiation0.66619384
123MP0003115_abnormal_respiratory_system0.66096333
124MP0005395_other_phenotype0.65989841
125MP0002092_abnormal_eye_morphology0.65075186
126MP0003699_abnormal_female_reproductive0.64770116
127MP0005621_abnormal_cell_physiology0.64558408
128MP0009703_decreased_birth_body0.63701143
129MP0002269_muscular_atrophy0.61858517
130MP0005266_abnormal_metabolism0.61697426
131MP0009333_abnormal_splenocyte_physiolog0.61482434
132MP0003937_abnormal_limbs/digits/tail_de0.61143288
133* MP0008770_decreased_survivor_rate0.59087526
134MP0000703_abnormal_thymus_morphology0.56893682
135MP0006072_abnormal_retinal_apoptosis0.56049878
136MP0003938_abnormal_ear_development0.56039314
137MP0003936_abnormal_reproductive_system0.55605735
138MP0000428_abnormal_craniofacial_morphol0.55360704
139MP0001286_abnormal_eye_development0.55222326
140MP0009053_abnormal_anal_canal0.54958550
141MP0005670_abnormal_white_adipose0.52704804
142MP0003186_abnormal_redox_activity0.52414614
143MP0000477_abnormal_intestine_morphology0.51099518
144MP0002114_abnormal_axial_skeleton0.51016136
145MP0009278_abnormal_bone_marrow0.49873301
146MP0003941_abnormal_skin_development0.49477672

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.79247933
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.38387275
3Breast hypoplasia (HP:0003187)4.26796701
4Cerebral hypomyelination (HP:0006808)4.00294493
5Impulsivity (HP:0100710)3.88996539
6Abnormality of the anterior horn cell (HP:0006802)3.82267009
7Degeneration of anterior horn cells (HP:0002398)3.82267009
8Acute necrotizing encephalopathy (HP:0006965)3.79209907
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.78750581
10Absent/shortened dynein arms (HP:0200106)3.78750581
11Carpal bone hypoplasia (HP:0001498)3.70549134
12Ependymoma (HP:0002888)3.65006998
13Increased hepatocellular lipid droplets (HP:0006565)3.64255471
14Abnormal mitochondria in muscle tissue (HP:0008316)3.52893216
15Mitochondrial inheritance (HP:0001427)3.44221362
16Acute encephalopathy (HP:0006846)3.39149943
17Lipid accumulation in hepatocytes (HP:0006561)3.33723141
18Patellar aplasia (HP:0006443)3.33155267
19Rough bone trabeculation (HP:0100670)3.26767555
20Abnormal respiratory epithelium morphology (HP:0012253)3.26688972
21Abnormal respiratory motile cilium morphology (HP:0005938)3.26688972
22Increased CSF lactate (HP:0002490)3.25463221
23Abnormality of the labia minora (HP:0012880)3.23225589
24Selective tooth agenesis (HP:0001592)3.19518723
25Aplasia/Hypoplasia of the patella (HP:0006498)3.16802299
26Premature ovarian failure (HP:0008209)3.16205821
27Progressive macrocephaly (HP:0004481)3.15064649
28Abnormality of cells of the erythroid lineage (HP:0012130)3.09596769
29Chronic bronchitis (HP:0004469)3.07113980
30Meckel diverticulum (HP:0002245)3.03150542
31True hermaphroditism (HP:0010459)3.01751715
32Abnormality of the ileum (HP:0001549)2.98899873
33Oral leukoplakia (HP:0002745)2.97700817
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.94632944
35Absent radius (HP:0003974)2.92305472
36Atrophy/Degeneration involving motor neurons (HP:0007373)2.84788711
37Abnormal number of erythroid precursors (HP:0012131)2.81660511
38Supernumerary spleens (HP:0009799)2.81022645
39Absent thumb (HP:0009777)2.79482369
40Hepatocellular necrosis (HP:0001404)2.78988901
41Abnormality of the preputium (HP:0100587)2.78699495
42Rhinitis (HP:0012384)2.78522169
43Abnormal respiratory motile cilium physiology (HP:0012261)2.77721727
44Medulloblastoma (HP:0002885)2.76192909
45Aplasia involving forearm bones (HP:0009822)2.71537682
46Absent forearm bone (HP:0003953)2.71537682
47Colon cancer (HP:0003003)2.71291532
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.69576268
49Tongue fasciculations (HP:0001308)2.67868032
50Hepatic necrosis (HP:0002605)2.67189595
51Multiple enchondromatosis (HP:0005701)2.65453599
52Abnormal spermatogenesis (HP:0008669)2.63133282
53Personality changes (HP:0000751)2.63014590
543-Methylglutaconic aciduria (HP:0003535)2.61156775
55Pancreatic fibrosis (HP:0100732)2.59271650
56Volvulus (HP:0002580)2.58426492
57Renal Fanconi syndrome (HP:0001994)2.58316531
58Secondary amenorrhea (HP:0000869)2.57650288
59Amyotrophic lateral sclerosis (HP:0007354)2.56883439
60Reticulocytopenia (HP:0001896)2.56358960
61Aplasia/hypoplasia of the humerus (HP:0006507)2.55013366
62Nephronophthisis (HP:0000090)2.52825551
63Cerebral edema (HP:0002181)2.52508172
64Rhabdomyosarcoma (HP:0002859)2.51233903
65Infertility (HP:0000789)2.49121188
66Abnormality of the lower motor neuron (HP:0002366)2.47641641
67CNS hypomyelination (HP:0003429)2.47209664
68Pancreatic cysts (HP:0001737)2.44734416
69Agnosia (HP:0010524)2.44492459
70Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43775498
71Abnormality of midbrain morphology (HP:0002418)2.39995392
72Molar tooth sign on MRI (HP:0002419)2.39995392
73Bone marrow hypocellularity (HP:0005528)2.36889010
74Muscle fibrillation (HP:0010546)2.36128024
75Abnormal lung lobation (HP:0002101)2.35986558
76Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35682186
77Abnormality of chromosome stability (HP:0003220)2.34731950
78Abnormality of the astrocytes (HP:0100707)2.33867874
79Astrocytoma (HP:0009592)2.33867874
80Increased serum lactate (HP:0002151)2.33090700
81Chromsome breakage (HP:0040012)2.32569475
82Increased intramyocellular lipid droplets (HP:0012240)2.31243706
83Horseshoe kidney (HP:0000085)2.29960940
84Trismus (HP:0000211)2.29718445
85Abnormal trabecular bone morphology (HP:0100671)2.27667140
86Ureteral duplication (HP:0000073)2.26761452
87Duodenal stenosis (HP:0100867)2.25252399
88Small intestinal stenosis (HP:0012848)2.25252399
89Sloping forehead (HP:0000340)2.23605745
90Neoplasm of the pancreas (HP:0002894)2.23378311
91Myelodysplasia (HP:0002863)2.21984347
92Facial cleft (HP:0002006)2.19776631
93Cleft eyelid (HP:0000625)2.19086607
94Microretrognathia (HP:0000308)2.15239116
95Medial flaring of the eyebrow (HP:0010747)2.13909411
96Premature graying of hair (HP:0002216)2.12363317
97Male infertility (HP:0003251)2.11536500
98Lactic acidosis (HP:0003128)2.11194095
99Abnormality of abdominal situs (HP:0011620)2.09282674
100Abdominal situs inversus (HP:0003363)2.09282674
101Macrocytic anemia (HP:0001972)2.07404862
102Abnormality of the umbilical cord (HP:0010881)2.07103758
103Hypoplasia of the radius (HP:0002984)2.06917436
104Aplastic anemia (HP:0001915)2.06494229
105Spinal muscular atrophy (HP:0007269)2.05732402
106Progressive muscle weakness (HP:0003323)2.04490070
107Short humerus (HP:0005792)2.04348847
108Tracheoesophageal fistula (HP:0002575)2.03022838
109Triphalangeal thumb (HP:0001199)2.02540635
110Neoplasm of striated muscle (HP:0009728)2.00704870
111Atresia of the external auditory canal (HP:0000413)1.97215362
112Congenital, generalized hypertrichosis (HP:0004540)1.96137286
113Methylmalonic acidemia (HP:0002912)1.96102066
114Glioma (HP:0009733)1.95903889
115Neoplasm of the oral cavity (HP:0100649)1.94389063
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94188346
117Postnatal microcephaly (HP:0005484)1.94169312
118Chronic hepatic failure (HP:0100626)1.94164815
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93252104
120Basal cell carcinoma (HP:0002671)1.92381536
121Sclerocornea (HP:0000647)1.90540637
122Septo-optic dysplasia (HP:0100842)1.90502830
123Squamous cell carcinoma (HP:0002860)1.89962286
124Nasal polyposis (HP:0100582)1.89840040
125Nephroblastoma (Wilms tumor) (HP:0002667)1.88736087
126Abnormality of the renal medulla (HP:0100957)1.88531784
127Optic disc pallor (HP:0000543)1.88134484
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87539188
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87539188
130Leukodystrophy (HP:0002415)1.87361647
131Abnormal ciliary motility (HP:0012262)1.87222608
132Delusions (HP:0000746)1.85053563
133Respiratory difficulties (HP:0002880)1.84763557
134Pendular nystagmus (HP:0012043)1.84053446
135Nephrogenic diabetes insipidus (HP:0009806)1.84052171
136Megaloblastic anemia (HP:0001889)1.82479494
137Male pseudohermaphroditism (HP:0000037)1.82106209
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81655062
139Abnormality of alanine metabolism (HP:0010916)1.81655062
140Hyperalaninemia (HP:0003348)1.81655062
141Cellular immunodeficiency (HP:0005374)1.81391471
142Absent septum pellucidum (HP:0001331)1.80914061
143Abnormality of the duodenum (HP:0002246)1.80500785
144Facial hemangioma (HP:0000329)1.79879113
145Death in infancy (HP:0001522)1.79480442
146Pallor (HP:0000980)1.79393264
147Congenital primary aphakia (HP:0007707)1.78949781
148B lymphocytopenia (HP:0010976)1.75320038
149Exercise intolerance (HP:0003546)1.74374006
150Increased muscle lipid content (HP:0009058)1.73574201
151Embryonal renal neoplasm (HP:0011794)1.72948989
152Exertional dyspnea (HP:0002875)1.72603232
153Respiratory failure (HP:0002878)1.72185106
154Abnormality of the septum pellucidum (HP:0007375)1.71538890
155Oligodactyly (hands) (HP:0001180)1.70822879
156Aplasia/hypoplasia of the uterus (HP:0008684)1.70763908
157Abnormality of renal resorption (HP:0011038)1.70329395
158Anencephaly (HP:0002323)1.70084573
159Hyperglycinemia (HP:0002154)1.69837926
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.66913097
161Gait imbalance (HP:0002141)1.66268460
162Median cleft lip (HP:0000161)1.65024347
163Increased serum pyruvate (HP:0003542)1.64252991
164Hypoplastic pelvis (HP:0008839)1.62401278
165Microvesicular hepatic steatosis (HP:0001414)1.62289537
166Abnormality of methionine metabolism (HP:0010901)1.62050300
167Optic nerve hypoplasia (HP:0000609)1.60422967
168Genital tract atresia (HP:0001827)1.59349803
169Abnormality of the pons (HP:0007361)1.59299153
170Lethargy (HP:0001254)1.58354000
171Oligodactyly (HP:0012165)1.58127850
172Abnormality of serum amino acid levels (HP:0003112)1.57846369
173Preaxial hand polydactyly (HP:0001177)1.57425916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.81149537
2BUB14.57954418
3PDK33.70431454
4PDK43.70431454
5EPHA23.35634817
6NEK23.25812354
7VRK23.04470373
8CDC72.82828918
9PNCK2.49915108
10PBK2.45238798
11TTK2.45091413
12PDK22.37615383
13SRPK12.32055359
14NEK12.26796145
15BRSK22.15991947
16NUAK12.15317192
17EIF2AK12.13021837
18DYRK32.09106132
19PLK12.03742384
20TESK12.03114207
21MST42.01838201
22TSSK61.99008046
23TRIM281.85830376
24TAF11.74514120
25CDK121.66486748
26WNK31.66134830
27BMPR1B1.63630180
28CHEK21.59848815
29TESK21.57741257
30NME21.55859977
31ICK1.54947233
32MAP4K21.51689629
33ACVR1B1.48719132
34AKT31.47795712
35PLK41.46893386
36PASK1.45946933
37BRSK11.45700540
38EIF2AK31.44129339
39AURKA1.42661886
40CDK71.38366325
41STK161.36156378
42BCR1.35885820
43AURKB1.35775928
44PLK31.33531353
45ATR1.25217732
46PRKD31.24688631
47RPS6KB21.24123349
48TLK11.23968369
49PLK21.18425504
50CHEK11.17616375
51CCNB11.15367039
52CSNK1G11.13908862
53CDK81.12692712
54LATS21.12135774
55CDK41.11329615
56SCYL21.07489891
57VRK11.05713564
58STK38L1.05250738
59FRK1.00561935
60TNIK1.00361857
61PAK41.00235543
62BRAF0.99657709
63MAP3K80.97350236
64CSNK1G30.95270344
65WNK40.93991407
66CSNK1G20.93541340
67ERBB30.93022815
68GRK10.91924661
69PAK10.89441978
70DYRK20.88253770
71MAP3K40.86884551
72ALK0.86772417
73MKNK10.85826402
74MKNK20.84327339
75MAP2K70.83537931
76PRKCI0.82842545
77* CDK20.81214055
78RPS6KA40.80816798
79INSRR0.79371684
80MAP3K110.78718608
81STK380.77397346
82CASK0.74490730
83STK390.73450150
84TYRO30.72835958
85TAOK20.72489292
86CSNK1A1L0.69070491
87NME10.67653783
88MAP3K120.65916094
89BCKDK0.65227186
90ATM0.64041155
91CSNK2A20.62701096
92TGFBR10.62652937
93CSNK2A10.59909122
94PIM10.59683386
95FGFR20.57424156
96CDK10.56596017
97MAPK130.54357417
98MTOR0.52708383
99ADRBK20.51857542
100PRKCG0.51478508
101CSNK1E0.50087037
102PIM20.49975965
103STK240.46677430
104STK100.46250502
105STK30.46046602
106ARAF0.45337011
107TAOK10.43669755
108STK40.42913123
109PRKCE0.42654953
110NLK0.41680715
111OXSR10.39168831
112MELK0.38361005
113CSNK1D0.36608461
114CDK190.35928667
115MAP3K50.35843790
116CDK30.35476696
117GRK60.35019350
118DAPK10.33605392
119EEF2K0.33280017
120MAP3K90.32691538
121CSNK1A10.31672738
122AKT20.31059520
123ZAK0.30417773
124MAP2K60.30000624
125CDK11A0.29746338
126CAMKK20.28638144
127MAPKAPK50.28300879
128DYRK1B0.27852785
129RPS6KA50.27161274
130CDK150.26289585
131CDK60.25428832
132EIF2AK20.24832891
133CDK180.24286313
134FGFR10.24047847
135CLK10.23826176
136LATS10.23574339
137MAP3K100.22970060
138BRD40.22121437
139CDK140.20183220
140MAP2K20.19073588
141RPS6KA10.18451479
142MARK30.18031554
143PINK10.17681109
144* GSK3B0.16944716
145PRKDC0.16074482

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.22318814
2Proteasome_Homo sapiens_hsa030504.08408386
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.97084015
4Mismatch repair_Homo sapiens_hsa034303.87618480
5RNA transport_Homo sapiens_hsa030133.69597135
6RNA polymerase_Homo sapiens_hsa030203.60289168
7Oxidative phosphorylation_Homo sapiens_hsa001903.28759226
8Spliceosome_Homo sapiens_hsa030403.20518864
9Ribosome_Homo sapiens_hsa030103.04890516
10Protein export_Homo sapiens_hsa030602.95608959
11Homologous recombination_Homo sapiens_hsa034402.76282341
12Base excision repair_Homo sapiens_hsa034102.74995537
13Nucleotide excision repair_Homo sapiens_hsa034202.70627678
14Pyrimidine metabolism_Homo sapiens_hsa002402.58955609
15Cell cycle_Homo sapiens_hsa041102.58259225
16Vitamin B6 metabolism_Homo sapiens_hsa007502.54144143
17Basal transcription factors_Homo sapiens_hsa030222.42992278
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42756115
19Fanconi anemia pathway_Homo sapiens_hsa034602.40276090
20mRNA surveillance pathway_Homo sapiens_hsa030152.05154957
21One carbon pool by folate_Homo sapiens_hsa006701.92709628
22Alzheimers disease_Homo sapiens_hsa050101.82545029
23RNA degradation_Homo sapiens_hsa030181.66808920
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62204376
25Oocyte meiosis_Homo sapiens_hsa041141.57089630
26Purine metabolism_Homo sapiens_hsa002301.54145265
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.46336254
28Pentose phosphate pathway_Homo sapiens_hsa000301.43955716
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42517190
30Propanoate metabolism_Homo sapiens_hsa006401.40566177
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40525432
32Non-homologous end-joining_Homo sapiens_hsa034501.39217651
33Fructose and mannose metabolism_Homo sapiens_hsa000511.37666995
34p53 signaling pathway_Homo sapiens_hsa041151.35537218
35Cardiac muscle contraction_Homo sapiens_hsa042601.29375119
36Regulation of autophagy_Homo sapiens_hsa041401.26767026
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26624505
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.22040993
39Epstein-Barr virus infection_Homo sapiens_hsa051691.20029639
40Steroid biosynthesis_Homo sapiens_hsa001001.08809724
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08598753
42Biosynthesis of amino acids_Homo sapiens_hsa012301.07446556
43Selenocompound metabolism_Homo sapiens_hsa004501.05167145
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02060116
45Butanoate metabolism_Homo sapiens_hsa006500.98074560
46Folate biosynthesis_Homo sapiens_hsa007900.95993345
47Phototransduction_Homo sapiens_hsa047440.93423556
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90938010
49Fatty acid elongation_Homo sapiens_hsa000620.87713488
50Huntingtons disease_Homo sapiens_hsa050160.84627173
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.81865847
52Carbon metabolism_Homo sapiens_hsa012000.80967108
53Systemic lupus erythematosus_Homo sapiens_hsa053220.77147255
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.74896379
55Glutathione metabolism_Homo sapiens_hsa004800.72809388
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71223004
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.69732041
58Viral carcinogenesis_Homo sapiens_hsa052030.69396472
59Sulfur relay system_Homo sapiens_hsa041220.68822394
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68066250
61Hedgehog signaling pathway_Homo sapiens_hsa043400.67410364
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62717462
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.61604024
64Peroxisome_Homo sapiens_hsa041460.60450923
65Hippo signaling pathway_Homo sapiens_hsa043900.60384472
66Antigen processing and presentation_Homo sapiens_hsa046120.59743541
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55570441
68Nitrogen metabolism_Homo sapiens_hsa009100.54503389
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52399611
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50002607
71Basal cell carcinoma_Homo sapiens_hsa052170.49135184
72Galactose metabolism_Homo sapiens_hsa000520.48494617
73mTOR signaling pathway_Homo sapiens_hsa041500.48455795
74HTLV-I infection_Homo sapiens_hsa051660.47931132
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47340202
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46837313
77Linoleic acid metabolism_Homo sapiens_hsa005910.46590006
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45969894
79Fatty acid metabolism_Homo sapiens_hsa012120.43847225
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43762378
81Herpes simplex infection_Homo sapiens_hsa051680.42255398
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39553314
83Tryptophan metabolism_Homo sapiens_hsa003800.39465570
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36246206
85Olfactory transduction_Homo sapiens_hsa047400.36069339
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35570700
87Alcoholism_Homo sapiens_hsa050340.35292218
88Arachidonic acid metabolism_Homo sapiens_hsa005900.35198106
89Metabolic pathways_Homo sapiens_hsa011000.34317601
90Thyroid cancer_Homo sapiens_hsa052160.34264293
91Fatty acid degradation_Homo sapiens_hsa000710.33042250
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32822931
93Nicotine addiction_Homo sapiens_hsa050330.32482815
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32326220
95Collecting duct acid secretion_Homo sapiens_hsa049660.30366534
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29332189
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28173599
98Renin-angiotensin system_Homo sapiens_hsa046140.28023118
99Pyruvate metabolism_Homo sapiens_hsa006200.26994964
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26112754
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25041972
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24979980
103MicroRNAs in cancer_Homo sapiens_hsa052060.24753822
104Legionellosis_Homo sapiens_hsa051340.24703474
105Tight junction_Homo sapiens_hsa045300.24545276
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24051911
107Retinol metabolism_Homo sapiens_hsa008300.23803110
108Chemical carcinogenesis_Homo sapiens_hsa052040.23801381
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.22605656
110Ether lipid metabolism_Homo sapiens_hsa005650.22071661
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22061349
112beta-Alanine metabolism_Homo sapiens_hsa004100.21067312
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.20334777
114Wnt signaling pathway_Homo sapiens_hsa043100.20288828
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.20272299
116Parkinsons disease_Homo sapiens_hsa050120.19737697
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19534504
118Taste transduction_Homo sapiens_hsa047420.19313421
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18062539
120AMPK signaling pathway_Homo sapiens_hsa041520.17601114
121Sulfur metabolism_Homo sapiens_hsa009200.17255141
122Colorectal cancer_Homo sapiens_hsa052100.17044141
123N-Glycan biosynthesis_Homo sapiens_hsa005100.16560697
124HIF-1 signaling pathway_Homo sapiens_hsa040660.16158122
125Glucagon signaling pathway_Homo sapiens_hsa049220.15606013
126Shigellosis_Homo sapiens_hsa051310.15527465
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14812955
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14240276
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13277493
130Fatty acid biosynthesis_Homo sapiens_hsa000610.13145569
131Notch signaling pathway_Homo sapiens_hsa043300.13043393
132Arginine and proline metabolism_Homo sapiens_hsa003300.11774594
133Endocytosis_Homo sapiens_hsa041440.09905604
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09381409
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.09263813
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08379532
137Glycerolipid metabolism_Homo sapiens_hsa005610.05476603
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04918139
139Pathways in cancer_Homo sapiens_hsa052000.04154869
140Circadian rhythm_Homo sapiens_hsa047100.03450375

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