COL10A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)9.94649171
2response to parathyroid hormone (GO:0071107)8.64661722
3phosphate ion homeostasis (GO:0055062)7.83432238
4trivalent inorganic anion homeostasis (GO:0072506)7.83432238
5positive regulation of extracellular matrix organization (GO:1903055)7.49679396
6hypotonic response (GO:0006971)7.26741054
7collagen fibril organization (GO:0030199)7.05298349
8negative regulation of biomineral tissue development (GO:0070168)6.72564607
9negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.50446566
10notochord development (GO:0030903)6.42332670
11regulation of plasminogen activation (GO:0010755)6.32050281
12regulation of extracellular matrix disassembly (GO:0010715)6.30922591
13limb bud formation (GO:0060174)6.10212801
14regulation of calcineurin-NFAT signaling cascade (GO:0070884)6.08388361
15chondroitin sulfate biosynthetic process (GO:0030206)6.07387895
16iron ion import (GO:0097286)6.05164257
17proteoglycan metabolic process (GO:0006029)6.01366918
18response to magnesium ion (GO:0032026)5.93610005
19* replacement ossification (GO:0036075)5.85251196
20* endochondral ossification (GO:0001958)5.85251196
21positive regulation of hormone biosynthetic process (GO:0046886)5.74088631
22keratan sulfate biosynthetic process (GO:0018146)5.59436912
23adhesion of symbiont to host cell (GO:0044650)5.40231601
24virion attachment to host cell (GO:0019062)5.40231601
25cellular glucuronidation (GO:0052695)5.34073648
26sphingomyelin metabolic process (GO:0006684)5.26451242
27nucleotide-sugar biosynthetic process (GO:0009226)5.17366280
28* cartilage development (GO:0051216)5.17352123
29positive regulation of osteoblast proliferation (GO:0033690)5.11614474
30sequestering of extracellular ligand from receptor (GO:0035581)4.96280199
31negative regulation of bone mineralization (GO:0030502)4.85602817
32positive regulation of endothelial cell differentiation (GO:0045603)4.77055817
33glucuronate metabolic process (GO:0019585)4.75790233
34uronic acid metabolic process (GO:0006063)4.75790233
35peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.75339998
36* skeletal system development (GO:0001501)4.74623548
37chondrocyte differentiation (GO:0002062)4.74549321
38positive regulation of epidermal cell differentiation (GO:0045606)4.74458600
39embryonic skeletal joint morphogenesis (GO:0060272)4.57444141
40adhesion of symbiont to host (GO:0044406)4.56127694
41keratan sulfate metabolic process (GO:0042339)4.53473597
42basement membrane organization (GO:0071711)4.44225586
43positive regulation of chondrocyte differentiation (GO:0032332)4.42756134
44tooth mineralization (GO:0034505)4.35953984
45decidualization (GO:0046697)4.28786910
46connective tissue development (GO:0061448)4.27741085
47* collagen catabolic process (GO:0030574)4.25886155
48positive regulation of cartilage development (GO:0061036)4.25833650
49negative regulation of complement activation (GO:0045916)4.25324334
50positive regulation of hormone metabolic process (GO:0032352)4.22775874
51regulation of steroid hormone biosynthetic process (GO:0090030)4.22729309
52type B pancreatic cell development (GO:0003323)4.21834181
53regulation of extracellular matrix organization (GO:1903053)4.21391587
54chondrocyte proliferation (GO:0035988)4.18771071
55positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.07099585
56* collagen metabolic process (GO:0032963)4.03162549
57endothelial cell morphogenesis (GO:0001886)3.99221247
58regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.98604457
59thrombin receptor signaling pathway (GO:0070493)3.96199411
60mesenchymal-epithelial cell signaling (GO:0060638)3.94275711
61glycoprotein metabolic process (GO:0009100)3.92631397
62positive regulation of receptor internalization (GO:0002092)3.92162602
63bone development (GO:0060348)3.90542383
64bone resorption (GO:0045453)3.89929319
65glycosaminoglycan biosynthetic process (GO:0006024)3.88478115
66* multicellular organismal catabolic process (GO:0044243)3.88058906
67adenosine metabolic process (GO:0046085)3.87644866
68positive regulation of alcohol biosynthetic process (GO:1902932)3.84210510
69aminoglycan biosynthetic process (GO:0006023)3.82758064
70negative regulation of protein activation cascade (GO:2000258)3.80920452
71response to gravity (GO:0009629)3.75561230
72* multicellular organismal macromolecule metabolic process (GO:0044259)3.75547261
73UDP-N-acetylglucosamine metabolic process (GO:0006047)3.74234762
74protein heterotrimerization (GO:0070208)3.72941838
75protein retention in ER lumen (GO:0006621)3.72307624
76skin morphogenesis (GO:0043589)3.72252713
77glomerular basement membrane development (GO:0032836)3.70274142
78cellular response to BMP stimulus (GO:0071773)3.68634440
79response to BMP (GO:0071772)3.68634440
80negative regulation of BMP signaling pathway (GO:0030514)3.60641694
81* multicellular organismal metabolic process (GO:0044236)3.60499032
82proteoglycan biosynthetic process (GO:0030166)3.60337936
83regulation of hormone biosynthetic process (GO:0046885)3.56579789
84chondroitin sulfate metabolic process (GO:0030204)3.54062856
85regulation of metalloenzyme activity (GO:0048552)3.52518388
86COPII vesicle coating (GO:0048208)3.50792956
87regulation of biomineral tissue development (GO:0070167)3.50013174
88* extracellular matrix disassembly (GO:0022617)3.46779277
89substrate-dependent cell migration (GO:0006929)3.46701485
90regulation of cartilage development (GO:0061035)3.45720345
91glomerular filtration (GO:0003094)3.44865392
92regulation of response to osmotic stress (GO:0047484)3.44771415
93maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43584634
94regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.40686941
95glycosaminoglycan catabolic process (GO:0006027)3.40669282
96import into cell (GO:0098657)3.38496439
97regulation of endothelial cell differentiation (GO:0045601)3.32713324
98endodermal cell differentiation (GO:0035987)3.31285893
99regulation of chondrocyte differentiation (GO:0032330)3.31199693
100pericardium development (GO:0060039)3.29925413
101myelin assembly (GO:0032288)3.29814406
102* ossification (GO:0001503)3.29801940
103AMP metabolic process (GO:0046033)3.27564938
104regulation of bone mineralization (GO:0030500)3.27149401
105positive regulation of Rho protein signal transduction (GO:0035025)3.26686063
106regulation of inositol phosphate biosynthetic process (GO:0010919)3.26013975
107negative regulation of ossification (GO:0030279)3.23661435
108negative regulation of humoral immune response (GO:0002921)3.22556367
109sulfur compound catabolic process (GO:0044273)3.22547618
110peptidyl-proline hydroxylation (GO:0019511)3.21154420
111lipopolysaccharide biosynthetic process (GO:0009103)3.19757299
112* extracellular matrix organization (GO:0030198)3.19514457
113* extracellular structure organization (GO:0043062)3.18214938
114bone trabecula formation (GO:0060346)3.17703234
115negative regulation of bone resorption (GO:0045779)3.16671283
116glycoprotein biosynthetic process (GO:0009101)3.16643622
117regulation of cardiac muscle hypertrophy (GO:0010611)3.15122524
118positive regulation of steroid biosynthetic process (GO:0010893)3.13281892
119cell adhesion mediated by integrin (GO:0033627)3.13269785
120bone mineralization (GO:0030282)3.12834286
121renal filtration (GO:0097205)3.11712085
122regulation of alkaline phosphatase activity (GO:0010692)3.09189135
123regulation of corticosteroid hormone secretion (GO:2000846)3.08889223
124aminoglycan catabolic process (GO:0006026)3.07570865
125positive regulation of steroid hormone secretion (GO:2000833)3.07185316
126cell migration involved in heart development (GO:0060973)3.06498276
127hyperosmotic salinity response (GO:0042538)3.03635410
128dermatan sulfate biosynthetic process (GO:0030208)3.03607421
129regulation of muscle hypertrophy (GO:0014743)3.01037123
130nucleotide-sugar metabolic process (GO:0009225)2.98365497
131glandular epithelial cell development (GO:0002068)2.97642016
132uterus development (GO:0060065)2.97098582
133dermatan sulfate metabolic process (GO:0030205)2.96570217
134cell volume homeostasis (GO:0006884)2.96314669
135regulation of bone remodeling (GO:0046850)2.96223972
136regulation of integrin-mediated signaling pathway (GO:2001044)2.96123261
137biomineral tissue development (GO:0031214)2.94939481
138mucopolysaccharide metabolic process (GO:1903510)2.94770536
139extracellular fibril organization (GO:0043206)2.94430662
140positive regulation of epidermis development (GO:0045684)2.92589146
141regulation of osteoblast proliferation (GO:0033688)2.91010158
142embryonic cranial skeleton morphogenesis (GO:0048701)2.89005614
143intestinal epithelial cell development (GO:0060576)2.88214233
144cellular response to vitamin D (GO:0071305)2.87934132
145negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.87671842
146atrioventricular valve morphogenesis (GO:0003181)2.84136127
147complement activation, classical pathway (GO:0006958)2.81845913
148negative regulation of protein localization to plasma membrane (GO:1903077)2.77435767
149regulation of cardioblast differentiation (GO:0051890)2.76359036
150vasculature development (GO:0001944)2.73308303
151phosphate ion transmembrane transport (GO:0035435)2.71107943
152tissue remodeling (GO:0048771)2.70982623
153establishment of tissue polarity (GO:0007164)2.66158420
154establishment of planar polarity (GO:0001736)2.66158420
155platelet-derived growth factor receptor signaling pathway (GO:0048008)2.65007513
156genitalia morphogenesis (GO:0035112)2.63006085
157extracellular negative regulation of signal transduction (GO:1900116)2.62473563
158extracellular regulation of signal transduction (GO:1900115)2.62473563
159muscle cell migration (GO:0014812)2.61301749
160vascular endothelial growth factor signaling pathway (GO:0038084)2.60778136
161Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.58350468
162fibril organization (GO:0097435)2.57003193
163negative regulation of chondrocyte differentiation (GO:0032331)2.56548592
164cartilage development involved in endochondral bone morphogenesis (GO:0060351)13.0949788
165cell aggregation (GO:0098743)11.7078724
166cartilage condensation (GO:0001502)11.7078724
167chondrocyte development (GO:0002063)10.6569215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.33913603
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.46609233
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.74548668
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.61006179
5GATA1_22025678_ChIP-Seq_K562_Human3.53038044
6AR_21572438_ChIP-Seq_LNCaP_Human3.38264799
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.97528719
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62985325
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.47850914
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45914198
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43919694
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.39317060
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.24997008
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20214579
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11549145
16CJUN_26792858_Chip-Seq_BT549_Human2.10078964
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.98440916
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.93127341
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.88520393
20NRF2_20460467_ChIP-Seq_MEFs_Mouse1.84051407
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.84051407
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82509975
23CLOCK_20551151_ChIP-Seq_293T_Human1.79973654
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78951259
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78549950
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65765715
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63532359
28JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62407066
29EGR1_19032775_ChIP-ChIP_M12_Human1.61019515
30TP53_16413492_ChIP-PET_HCT116_Human1.60801730
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59022575
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58140992
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57263344
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55832024
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55489561
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.50247376
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.49824997
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47844100
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45961782
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45906280
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.44950583
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44785133
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.43676409
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42824796
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.42723726
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40658209
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.39239370
48AHR_22903824_ChIP-Seq_MCF-7_Human1.38498126
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38040830
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35555466
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35555466
52SOX2_20726797_ChIP-Seq_SW620_Human1.34406296
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33740052
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33052227
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32731668
56RXR_22108803_ChIP-Seq_LS180_Human1.30082657
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29277327
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28998488
59* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28894329
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28459129
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.28210839
62TP53_18474530_ChIP-ChIP_U2OS_Human1.27597713
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27494584
64TBX20_22328084_ChIP-Seq_HEART_Mouse1.26908610
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.26908610
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24028589
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.23004475
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22389524
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.19522802
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17965559
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17884691
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.17878727
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17282461
74VDR_24787735_ChIP-Seq_THP-1_Human1.17162798
75SMAD4_21799915_ChIP-Seq_A2780_Human1.16248384
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14480497
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.14048359
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13950328
79GATA3_24758297_ChIP-Seq_MCF-7_Human1.13467191
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12937180
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12841188
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12729710
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10462340
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10433252
85GBX2_23144817_ChIP-Seq_PC3_Human1.10198314
86P53_22387025_ChIP-Seq_ESCs_Mouse1.10098873
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10084113
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09114742
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08539326
90KDM2B_26808549_Chip-Seq_K562_Human1.08079121
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07767483
92BRD4_25478319_ChIP-Seq_HGPS_Human1.07725973
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07067976
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07067976
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.06742761
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.06666284
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06576201
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.04149541
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03996666
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.03274622
101GATA2_21666600_ChIP-Seq_HMVEC_Human1.03061487
102SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03038750
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.02137961
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01933839
105FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01030650
106CDX2_22108803_ChIP-Seq_LS180_Human1.00735415
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00717297
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00410781
109SA1_22415368_ChIP-Seq_MEFs_Mouse1.00141581
110SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00006408
111TCF4_22108803_ChIP-Seq_LS180_Human0.99671807
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99070559
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98837758
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98001323
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98001323
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97964353
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97861437
118ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97269812
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.97133491
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96622364
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.96612024
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96105187
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95988473
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95324356
125PU1_27457419_Chip-Seq_LIVER_Mouse0.95315792
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94882847
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94730808
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94321794
129P300_19829295_ChIP-Seq_ESCs_Human0.94282075
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93723897
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93603189
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.93278246
133ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92692666
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.92101650
135JUN_21703547_ChIP-Seq_K562_Human0.91505956
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91409332
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90625497
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90198807
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90140105
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89213947
141SOX2_18555785_Chip-Seq_ESCs_Mouse0.88790529
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87809161
143FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87506650
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87429653
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87258247
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87069554
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.86966472
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86816463
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86585293
150TP63_23658742_ChIP-Seq_EP156T_Human0.86487444
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86277513
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85058383
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84817226
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84295976
155ATF3_27146783_Chip-Seq_COLON_Human0.83467873
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82933898
157CTCF_21964334_Chip-Seq_Bcells_Human0.82499000
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81332661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.57126207
2MP0004134_abnormal_chest_morphology5.53959474
3MP0002933_joint_inflammation5.21643989
4MP0005503_abnormal_tendon_morphology4.22471957
5MP0002282_abnormal_trachea_morphology4.22225765
6MP0009384_cardiac_valve_regurgitation4.19100662
7* MP0000163_abnormal_cartilage_morphology3.93093369
8MP0003123_paternal_imprinting3.49468039
9* MP0002115_abnormal_skeleton_extremities3.19095123
10MP0009780_abnormal_chondrocyte_physiolo3.15902931
11* MP0009250_abnormal_appendicular_skeleto3.14420759
12MP0003283_abnormal_digestive_organ2.92269601
13MP0001542_abnormal_bone_strength2.74264902
14* MP0002113_abnormal_skeleton_development2.62773847
15MP0002089_abnormal_postnatal_growth/wei2.62206374
16MP0003787_abnormal_imprinting2.49302502
17MP0002896_abnormal_bone_mineralization2.48840919
18MP0005257_abnormal_intraocular_pressure2.46819405
19MP0005083_abnormal_biliary_tract2.44887043
20MP0002163_abnormal_gland_morphology2.39232686
21MP0001533_abnormal_skeleton_physiology2.37350828
22MP0000751_myopathy2.36878857
23MP0006054_spinal_hemorrhage2.21373774
24MP0005390_skeleton_phenotype2.20617492
25MP0001299_abnormal_eye_distance/2.19902935
26MP0000762_abnormal_tongue_morphology2.19279171
27MP0005508_abnormal_skeleton_morphology2.19109695
28MP0008438_abnormal_cutaneous_collagen1.97438642
29MP0000049_abnormal_middle_ear1.89909486
30MP0001270_distended_abdomen1.82844673
31* MP0003795_abnormal_bone_structure1.82421678
32* MP0002109_abnormal_limb_morphology1.82027738
33MP0002060_abnormal_skin_morphology1.78763604
34MP0002116_abnormal_craniofacial_bone1.72408356
35MP0002108_abnormal_muscle_morphology1.69733546
36MP0000465_gastrointestinal_hemorrhage1.68356507
37MP0003279_aneurysm1.67467661
38MP0003656_abnormal_erythrocyte_physiolo1.62658674
39MP0002998_abnormal_bone_remodeling1.51856885
40MP0003436_decreased_susceptibility_to1.47038565
41MP0000569_abnormal_digit_pigmentation1.45305129
42MP0010368_abnormal_lymphatic_system1.44636768
43MP0008004_abnormal_stomach_pH1.42207560
44MP0003755_abnormal_palate_morphology1.41314356
45MP0003566_abnormal_cell_adhesion1.40314668
46MP0001663_abnormal_digestive_system1.37751222
47MP0003705_abnormal_hypodermis_morpholog1.36395274
48MP0001873_stomach_inflammation1.35769178
49MP0002909_abnormal_adrenal_gland1.33978992
50MP0004883_abnormal_blood_vessel1.28197479
51MP0005023_abnormal_wound_healing1.27619744
52MP0005379_endocrine/exocrine_gland_phen1.24556211
53MP0000343_altered_response_to1.24278627
54MP0005381_digestive/alimentary_phenotyp1.23667769
55* MP0000432_abnormal_head_morphology1.21356298
56MP0003195_calcinosis1.20410979
57MP0001879_abnormal_lymphatic_vessel1.17066647
58MP0003121_genomic_imprinting1.15566841
59MP0005275_abnormal_skin_tensile1.09851339
60MP0003448_altered_tumor_morphology1.09561576
61MP0003806_abnormal_nucleotide_metabolis1.09098595
62MP0000767_abnormal_smooth_muscle1.08474675
63MP0003183_abnormal_peptide_metabolism1.03147614
64MP0002111_abnormal_tail_morphology1.02197706
65MP0010352_gastrointestinal_tract_polyps1.00280962
66MP0004272_abnormal_basement_membrane0.98941455
67MP0002168_other_aberrant_phenotype0.97387513
68MP0002254_reproductive_system_inflammat0.96379903
69MP0002233_abnormal_nose_morphology0.95736083
70MP0003385_abnormal_body_wall0.91356503
71* MP0002114_abnormal_axial_skeleton0.90506195
72MP0003091_abnormal_cell_migration0.90048430
73MP0003300_gastrointestinal_ulcer0.86816976
74MP0004019_abnormal_vitamin_homeostasis0.86758567
75MP0001963_abnormal_hearing_physiology0.86455162
76MP0001958_emphysema0.85985069
77MP0002735_abnormal_chemical_nociception0.85600191
78MP0004084_abnormal_cardiac_muscle0.85320279
79MP0004484_altered_response_of0.84493335
80MP0000013_abnormal_adipose_tissue0.82151117
81MP0003942_abnormal_urinary_system0.81262937
82* MP0003935_abnormal_craniofacial_develop0.80306677
83MP0005623_abnormal_meninges_morphology0.80191742
84MP0005164_abnormal_response_to0.79456085
85MP0000681_abnormal_thyroid_gland0.79368115
86MP0003868_abnormal_feces_composition0.79159896
87MP0009697_abnormal_copulation0.74762191
88MP0002295_abnormal_pulmonary_circulatio0.74377878
89MP0005395_other_phenotype0.73431411
90MP0003122_maternal_imprinting0.71556313
91MP0010386_abnormal_urinary_bladder0.71424357
92MP0005171_absent_coat_pigmentation0.70660118
93MP0005464_abnormal_platelet_physiology0.70354134
94MP0004197_abnormal_fetal_growth/weight/0.69420754
95MP0003303_peritoneal_inflammation0.68429854
96MP0001664_abnormal_digestion0.65123037
97MP0003937_abnormal_limbs/digits/tail_de0.64976437
98MP0003119_abnormal_digestive_system0.64586199
99MP0005165_increased_susceptibility_to0.63077764
100MP0005248_abnormal_Harderian_gland0.62226023
101MP0003045_fibrosis0.61428330
102MP0001243_abnormal_dermal_layer0.60497914
103MP0001666_abnormal_nutrient_absorption0.60020020
104MP0002234_abnormal_pharynx_morphology0.59396281
105MP0001943_abnormal_respiration0.58551587
106MP0000249_abnormal_blood_vessel0.57208955
107MP0001790_abnormal_immune_system0.56855834
108MP0005387_immune_system_phenotype0.56855834
109MP0001849_ear_inflammation0.56372695
110MP0000604_amyloidosis0.56150715
111MP0002932_abnormal_joint_morphology0.54105724
112MP0005666_abnormal_adipose_tissue0.52187255
113MP0001340_abnormal_eyelid_morphology0.47140573
114MP0000858_altered_metastatic_potential0.46793453
115MP0002139_abnormal_hepatobiliary_system0.46586232
116MP0000003_abnormal_adipose_tissue0.45923271
117MP0002133_abnormal_respiratory_system0.45670202
118MP0005388_respiratory_system_phenotype0.45670202
119MP0001614_abnormal_blood_vessel0.45322543
120MP0001348_abnormal_lacrimal_gland0.44401186
121MP0010771_integument_phenotype0.44031726
122MP0001175_abnormal_lung_morphology0.42870162
123MP0010234_abnormal_vibrissa_follicle0.42687056
124MP0000462_abnormal_digestive_system0.42632371
125MP0010030_abnormal_orbit_morphology0.41986499
126MP0008775_abnormal_heart_ventricle0.41216516
127MP0001765_abnormal_ion_homeostasis0.40861865
128MP0003075_altered_response_to0.40615526
129MP0000733_abnormal_muscle_development0.39873388
130MP0000627_abnormal_mammary_gland0.39138324
131MP0002177_abnormal_outer_ear0.37971081
132MP0000230_abnormal_systemic_arterial0.37809985
133MP0005187_abnormal_penis_morphology0.37268813
134MP0001286_abnormal_eye_development0.35995292
135MP0005166_decreased_susceptibility_to0.35811838
136MP0002128_abnormal_blood_circulation0.35566554
137MP0005076_abnormal_cell_differentiation0.35244161
138MP0009278_abnormal_bone_marrow0.34984351
139MP0001177_atelectasis0.32881539
140MP0005369_muscle_phenotype0.32697712
141MP0004036_abnormal_muscle_relaxation0.31989473
142MP0001851_eye_inflammation0.30082446
143MP0005193_abnormal_anterior_eye0.29474111

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.79053693
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)9.14218409
3Irregular epiphyses (HP:0010582)8.92318752
4Hypophosphatemic rickets (HP:0004912)7.99487029
5Small epiphyses (HP:0010585)7.24953579
6Abnormal tarsal ossification (HP:0008369)6.94546560
7Vitreoretinal degeneration (HP:0000655)6.93983827
8Delayed epiphyseal ossification (HP:0002663)6.18874255
9Cupped ribs (HP:0000887)6.15393083
10Increased density of long bones (HP:0006392)6.02655853
11* Metaphyseal cupping (HP:0003021)5.82985640
12Flat capital femoral epiphysis (HP:0003370)5.77640680
13Hypoplastic ischia (HP:0003175)5.69394805
14Overgrowth (HP:0001548)5.43747649
15* Genu varum (HP:0002970)5.42710844
16Spondylolisthesis (HP:0003302)5.29510564
17Abnormality of calcium-phosphate metabolism (HP:0100530)5.17833950
18Flat acetabular roof (HP:0003180)5.16858798
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.09250388
20Abnormal foot bone ossification (HP:0010675)5.08829764
21Craniofacial hyperostosis (HP:0004493)5.06551771
22Broad ribs (HP:0000885)5.05744786
23Abnormality of the ischium (HP:0003174)5.02352463
24* Metaphyseal dysplasia (HP:0100255)4.78949273
25Persistence of primary teeth (HP:0006335)4.71776302
26Facial diplegia (HP:0001349)4.63501567
27* Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.56104795
28* Abnormality of femoral epiphyses (HP:0006499)4.56104795
29Cranial hyperostosis (HP:0004437)4.42781825
30Flattened epiphyses (HP:0003071)4.30652903
31* Abnormality of the vertebral endplates (HP:0005106)4.30388152
32Short femoral neck (HP:0100864)4.30333270
33* Abnormality of the epiphysis of the femoral head (HP:0010574)4.18906794
34Osteoarthritis (HP:0002758)4.04942103
35Aortic dissection (HP:0002647)4.02376580
36Premature rupture of membranes (HP:0001788)4.01498509
37Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.99507788
38Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.97093517
39Absent epiphyses (HP:0010577)3.97093517
40Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.88303558
41* Abnormality of the femoral head (HP:0003368)3.84010408
42Abnormality of carpal bone ossification (HP:0006257)3.83109024
43Osteolytic defects of the hand bones (HP:0009699)3.81284780
44Osteolytic defects of the phalanges of the hand (HP:0009771)3.81284780
45Arthropathy (HP:0003040)3.81167369
46Metaphyseal irregularity (HP:0003025)3.78510556
47* Mild short stature (HP:0003502)3.59828343
48Protrusio acetabuli (HP:0003179)3.57615411
49* Irregular vertebral endplates (HP:0003301)3.57403171
50Carpal bone hypoplasia (HP:0001498)3.49165902
51Rickets (HP:0002748)3.43487712
52* Waddling gait (HP:0002515)3.30289921
53Neonatal short-limb short stature (HP:0008921)3.28503426
54* Coxa vara (HP:0002812)3.24492850
55* Platyspondyly (HP:0000926)3.21127372
56Wormian bones (HP:0002645)3.19696080
57Beaking of vertebral bodies (HP:0004568)3.19058058
58* Tibial bowing (HP:0002982)3.18719184
59Abnormal vertebral ossification (HP:0100569)3.18528953
60Barrel-shaped chest (HP:0001552)3.17646374
61Limited hip movement (HP:0008800)3.12410171
62Spinal cord compression (HP:0002176)3.08587163
63Ovoid vertebral bodies (HP:0003300)3.03665435
64Osteomalacia (HP:0002749)3.02127290
65Aplasia/hypoplasia of the femur (HP:0005613)2.99279856
66Abnormal hand bone ossification (HP:0010660)2.98848130
67Abnormal ossification of hand bones (HP:0005921)2.97671617
68Stillbirth (HP:0003826)2.94740728
69Limited elbow extension (HP:0001377)2.91756182
70Ulnar bowing (HP:0003031)2.91700835
71* Femoral bowing (HP:0002980)2.91236975
72Vertebral clefting (HP:0008428)2.90605164
73Atrophic scars (HP:0001075)2.90577326
74Protuberant abdomen (HP:0001538)2.88425993
75Abnormality of the proximal phalanges of the hand (HP:0009834)2.84552382
76Hip contracture (HP:0003273)2.84114111
77Abnormality of the pubic bones (HP:0003172)2.82320101
78Abnormality of the phalanges of the 2nd finger (HP:0009541)2.81596540
79Soft skin (HP:0000977)2.78889118
80Sudden death (HP:0001699)2.77803339
81Choanal stenosis (HP:0000452)2.77014231
82Hypoplasia of the odontoid process (HP:0003311)2.74250476
83Hypophosphatemia (HP:0002148)2.71440298
84Peritonitis (HP:0002586)2.69385579
85Cervical subluxation (HP:0003308)2.65544927
86* Enlarged epiphyses (HP:0010580)2.65239699
87Mesomelia (HP:0003027)2.64485013
88Aortic aneurysm (HP:0004942)2.64294371
89Delayed closure of the anterior fontanelle (HP:0001476)2.63863172
90Exostoses (HP:0100777)2.63496440
91Lumbar hyperlordosis (HP:0002938)2.55724272
92Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.53995595
93Relative macrocephaly (HP:0004482)2.52946982
94Thoracolumbar scoliosis (HP:0002944)2.51902810
95Flared iliac wings (HP:0002869)2.45496014
96Fragile skin (HP:0001030)2.41786555
97Absent frontal sinuses (HP:0002688)2.40974949
98Abnormality of the lumbar spine (HP:0100712)2.38782545
99Genu recurvatum (HP:0002816)2.35237165
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35066827
101Arterial tortuosity (HP:0005116)2.33798553
102Micromelia (HP:0002983)2.29150203
103Bladder diverticulum (HP:0000015)2.28743466
104Abnormality of the odontoid process (HP:0003310)2.28075675
105Vascular tortuosity (HP:0004948)2.28042646
106Flared metaphyses (HP:0003015)2.24483192
107Abnormality of incisor morphology (HP:0011063)2.24281246
108Abnormality of Sharpey fibers (HP:0100685)2.20194181
109Abnormality of the 2nd finger (HP:0004100)2.12456976
110Abnormality of primary teeth (HP:0006481)2.12051241
111Ulnar deviation of the wrist (HP:0003049)2.10637664
112Abnormality of the vitreous humor (HP:0004327)2.09098565
113Thin ribs (HP:0000883)2.07290497
114Short middle phalanx of the 5th finger (HP:0004220)2.07016142
115Elevated alkaline phosphatase (HP:0003155)2.05557998
116Disproportionate short-trunk short stature (HP:0003521)2.05423766
117Hypoplastic pelvis (HP:0008839)2.05281611
118Delayed cranial suture closure (HP:0000270)2.05101515
119Papilledema (HP:0001085)11.3654881
120Wide anterior fontanel (HP:0000260)1.99611591
121Mitral valve prolapse (HP:0001634)1.99381169
122Long clavicles (HP:0000890)1.97179228
123Joint stiffness (HP:0001387)1.97131981
124Blue sclerae (HP:0000592)1.97067358
125Cardiovascular calcification (HP:0011915)1.96312877
126Hepatoblastoma (HP:0002884)1.95473306
127Asymmetry of the thorax (HP:0001555)1.95236369
128Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.94122491
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93103116
130Cerebral aneurysm (HP:0004944)1.91760020
131Glossoptosis (HP:0000162)1.91413825
132Short ribs (HP:0000773)1.91224990
133Broad thumb (HP:0011304)1.87667473
134Biconcave vertebral bodies (HP:0004586)1.85878626
135Abnormal cortical bone morphology (HP:0003103)1.85186365
136Mixed hearing impairment (HP:0000410)1.85156406
137Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.84430318
138Alopecia of scalp (HP:0002293)1.84382572
139Narrow palate (HP:0000189)1.83981205
140Follicular hyperkeratosis (HP:0007502)1.82879583
141Decreased skull ossification (HP:0004331)1.82555884
142Abnormality of the middle phalanges of the toes (HP:0010183)1.81871442
143* Broad phalanx (HP:0006009)1.81849882
144Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.81685217
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81275520
146Genu valgum (HP:0002857)1.81098928
147Rhizomelia (HP:0008905)1.80031340
148Abnormality of alkaline phosphatase activity (HP:0004379)1.78038207
149Vertebral hypoplasia (HP:0008417)1.77855826
150Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77855826
151Radial bowing (HP:0002986)1.77649857
152Dilatation of the ascending aorta (HP:0005111)1.77393038
153Severe short stature (HP:0003510)1.74417622
154Abnormality of the frontal sinuses (HP:0002687)1.73959863
155* Short middle phalanx of finger (HP:0005819)1.71327032
156Abnormality of dentin (HP:0010299)1.70404099
157Abnormality of skull ossification (HP:0002703)1.69684040
158Hypoplastic ilia (HP:0000946)1.69661727
159Increased corneal curvature (HP:0100692)1.69660613
160Keratoconus (HP:0000563)1.69660613
161Hydroxyprolinuria (HP:0003080)1.69203937
162Abnormal enzyme/coenzyme activity (HP:0012379)1.68609692
163Bowing of the arm (HP:0006488)1.68283694
164Bowed forearm bones (HP:0003956)1.68283694
165Hyperextensible skin (HP:0000974)1.66016242
166Bone pain (HP:0002653)1.65590452
167Constricted visual fields (HP:0001133)1.65308997
168Ridged nail (HP:0001807)1.65229024
169Infantile muscular hypotonia (HP:0008947)1.63460448
170Vascular calcification (HP:0004934)1.62145355
171Subacute progressive viral hepatitis (HP:0006572)1.61600584
172Aplasia/Hypoplasia of the scapulae (HP:0006713)1.61066907
173Hypoplastic scapulae (HP:0000882)1.61066907
174Progressive visual loss (HP:0000529)1.59479520
175Spinal cord lesions (HP:0100561)1.58431970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L7.07057462
2STK246.80147423
3DDR25.93521175
4MST1R4.32558955
5MAP3K33.99225323
6PRKG23.57577314
7PDGFRA3.32950692
8NLK3.08461132
9MYLK2.83509591
10NME12.79331641
11PIK3CA2.53653119
12EPHA22.23844332
13TYK22.21404485
14DMPK2.05314829
15MAP3K62.03930432
16PDK21.97680130
17JAK11.91833731
18STK31.88094273
19PLK21.85173209
20WNK41.81998719
21EPHA31.79740191
22PIM21.75514979
23MST41.74641577
24AKT31.72656148
25FGFR41.71560324
26BMPR1B1.62543781
27MUSK1.62487725
28PAK41.53693937
29TNIK1.52747323
30CDC42BPA1.50445675
31KSR21.49977440
32BLK1.46356736
33TAOK11.45919431
34KSR11.41470966
35NEK91.41098426
36LATS11.40758474
37PBK1.37790649
38SGK21.36911304
39ERBB31.36082513
40PAK31.30510480
41KIT1.29801857
42TGFBR11.29346737
43NEK61.20382059
44EPHA41.18414034
45CAMKK21.09421616
46PAK61.07701064
47ERBB21.07338413
48STK391.06028797
49BCR1.01947876
50SGK30.94972994
51FGFR30.94641478
52RAF10.94261697
53EIF2AK30.93762909
54ZAP700.90463603
55MAPK70.90443683
56CAMK1G0.89562999
57DYRK1A0.85156376
58TEC0.85111101
59MAP3K130.83245845
60LMTK20.81900674
61MAPK120.79325544
62PRKG10.78887244
63STK380.76763569
64TRIB30.75393759
65SGK4940.71927756
66SGK2230.71927756
67SIK10.71407468
68PKN20.67494894
69WNK10.67120568
70MARK20.61410256
71RET0.59566447
72CDK60.59013196
73NME20.58793897
74ERN10.58222461
75NUAK10.56917624
76TRPM70.56183545
77PRKCE0.54965481
78ROCK10.53894556
79FLT30.53253241
80MKNK20.52478341
81FGFR10.52049778
82CSK0.51002212
83HIPK20.50630544
84MAP2K10.50530604
85PDK10.49939215
86MAPK150.49668277
87MTOR0.49667961
88PDGFRB0.49391876
89MAP2K30.48734936
90MAP3K70.48650582
91LIMK10.47643822
92RIPK10.47042262
93PRKD20.46901794
94MAPK100.46038249
95ACVR1B0.45868342
96IRAK10.45427435
97CHUK0.43936116
98HCK0.43919443
99MAPKAPK30.43300242
100JAK30.42532935
101MAPK40.42003450
102TTN0.41991993
103FRK0.41407940
104PTK20.41008721
105GSK3A0.40815738
106MAP3K20.39716043
107OXSR10.39173088
108MAP3K140.39093935
109PTK2B0.38994286
110IKBKE0.38302807
111NTRK20.37502016
112ABL20.36802946
113MELK0.36639336
114PRKACG0.35822133
115NTRK10.35420624
116CAMKK10.34785062
117PDPK10.34509297
118MAP2K60.33478270
119MET0.33427101
120TNK20.33343961
121PIM10.31212073
122BRD40.30880469
123EPHB10.30401044
124PLK30.30004365
125GRK50.27470046
126CDK90.25896118
127SIK30.24522807
128SGK10.24466028
129TGFBR20.20538997
130PHKG20.19700589
131PHKG10.19700589
132FER0.19534994
133LATS20.19151873
134MAP3K50.18783773
135PAK20.18724357
136PIK3CG0.18324811
137BMX0.18167779
138MAP3K40.17991432
139MKNK10.17406392
140DAPK20.16875176
141TESK10.16851828
142MAPK30.16659659
143ABL10.16639436
144BRSK20.13956910
145CDK80.13501192
146MAPKAPK50.12957884
147INSR0.12800454
148PRKCD0.12104089
149ADRBK10.11517309
150IGF1R0.11497974
151PRKAA20.11324775

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.84567781
2ECM-receptor interaction_Homo sapiens_hsa045126.31085949
3* Protein digestion and absorption_Homo sapiens_hsa049744.21819048
4Steroid biosynthesis_Homo sapiens_hsa001002.69238165
5Focal adhesion_Homo sapiens_hsa045102.62014888
6Complement and coagulation cascades_Homo sapiens_hsa046102.14877494
7Malaria_Homo sapiens_hsa051442.01651437
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99710404
9Sphingolipid metabolism_Homo sapiens_hsa006001.87438422
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.82957939
11PI3K-Akt signaling pathway_Homo sapiens_hsa041511.77475914
12Olfactory transduction_Homo sapiens_hsa047401.72988674
13Folate biosynthesis_Homo sapiens_hsa007901.71112552
14Ovarian steroidogenesis_Homo sapiens_hsa049131.67556293
15Staphylococcus aureus infection_Homo sapiens_hsa051501.64160100
16TGF-beta signaling pathway_Homo sapiens_hsa043501.60978051
17Starch and sucrose metabolism_Homo sapiens_hsa005001.57968724
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51892886
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48092348
20Melanoma_Homo sapiens_hsa052181.40776436
21Sulfur metabolism_Homo sapiens_hsa009201.39470611
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.36531267
23Adherens junction_Homo sapiens_hsa045201.36151085
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34242207
25Lysosome_Homo sapiens_hsa041421.30460556
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19284666
27Rheumatoid arthritis_Homo sapiens_hsa053231.17073556
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16654818
29Protein export_Homo sapiens_hsa030601.16186880
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09670714
31Proteoglycans in cancer_Homo sapiens_hsa052051.07658850
32B cell receptor signaling pathway_Homo sapiens_hsa046621.03020178
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02446410
34Hippo signaling pathway_Homo sapiens_hsa043901.01984632
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00925209
36Pertussis_Homo sapiens_hsa051330.95440975
37cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94206940
38Toxoplasmosis_Homo sapiens_hsa051450.90610836
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90337593
40Vitamin digestion and absorption_Homo sapiens_hsa049770.89806180
41Selenocompound metabolism_Homo sapiens_hsa004500.89516676
42Chronic myeloid leukemia_Homo sapiens_hsa052200.89361888
43Phagosome_Homo sapiens_hsa041450.89358108
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.88843974
45Dorso-ventral axis formation_Homo sapiens_hsa043200.88096986
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86376441
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.85909974
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85886386
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.85076211
50Thyroid cancer_Homo sapiens_hsa052160.84561075
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82861794
52Allograft rejection_Homo sapiens_hsa053300.82661193
53Prolactin signaling pathway_Homo sapiens_hsa049170.82332967
54Bladder cancer_Homo sapiens_hsa052190.82041926
55Gap junction_Homo sapiens_hsa045400.81929742
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80313289
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79437644
58Oxytocin signaling pathway_Homo sapiens_hsa049210.77062615
59Ras signaling pathway_Homo sapiens_hsa040140.75045982
60Long-term depression_Homo sapiens_hsa047300.75005984
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74621380
62Pathways in cancer_Homo sapiens_hsa052000.73955667
63Hedgehog signaling pathway_Homo sapiens_hsa043400.73204457
64Hematopoietic cell lineage_Homo sapiens_hsa046400.71948377
65Leishmaniasis_Homo sapiens_hsa051400.71533754
66Hepatitis B_Homo sapiens_hsa051610.67919202
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65544059
68Endometrial cancer_Homo sapiens_hsa052130.64634614
69Osteoclast differentiation_Homo sapiens_hsa043800.63290065
70Circadian entrainment_Homo sapiens_hsa047130.63188275
71Salivary secretion_Homo sapiens_hsa049700.63026713
72Dilated cardiomyopathy_Homo sapiens_hsa054140.62595543
73Arginine and proline metabolism_Homo sapiens_hsa003300.62342854
74VEGF signaling pathway_Homo sapiens_hsa043700.61854694
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61427399
76Viral myocarditis_Homo sapiens_hsa054160.61048694
77Wnt signaling pathway_Homo sapiens_hsa043100.60905294
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59951716
79Pancreatic secretion_Homo sapiens_hsa049720.59833544
80Glioma_Homo sapiens_hsa052140.59052830
81ABC transporters_Homo sapiens_hsa020100.58245159
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57300196
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.57232354
84Collecting duct acid secretion_Homo sapiens_hsa049660.56989484
85Measles_Homo sapiens_hsa051620.56943690
86Chemokine signaling pathway_Homo sapiens_hsa040620.56832415
87Asthma_Homo sapiens_hsa053100.56268410
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55891325
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.55842143
90Tuberculosis_Homo sapiens_hsa051520.55617027
91Influenza A_Homo sapiens_hsa051640.55039605
92Notch signaling pathway_Homo sapiens_hsa043300.54515793
93Mineral absorption_Homo sapiens_hsa049780.54206224
94FoxO signaling pathway_Homo sapiens_hsa040680.54200350
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54096485
96TNF signaling pathway_Homo sapiens_hsa046680.53219790
97Graft-versus-host disease_Homo sapiens_hsa053320.53117441
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52629080
99Autoimmune thyroid disease_Homo sapiens_hsa053200.51994408
100Hepatitis C_Homo sapiens_hsa051600.51722382
101Type I diabetes mellitus_Homo sapiens_hsa049400.51660946
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51428284
103Platelet activation_Homo sapiens_hsa046110.50431599
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.49814095
105Colorectal cancer_Homo sapiens_hsa052100.48811165
106Non-small cell lung cancer_Homo sapiens_hsa052230.48649908
107T cell receptor signaling pathway_Homo sapiens_hsa046600.48415814
108N-Glycan biosynthesis_Homo sapiens_hsa005100.48403154
109Lysine degradation_Homo sapiens_hsa003100.47586561
110Other glycan degradation_Homo sapiens_hsa005110.47244043
111Circadian rhythm_Homo sapiens_hsa047100.45510929
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45218486
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44849442
114Endocytosis_Homo sapiens_hsa041440.43758229
115Renin secretion_Homo sapiens_hsa049240.43133674
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.42334758
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40904941
118Apoptosis_Homo sapiens_hsa042100.40406994
119Basal cell carcinoma_Homo sapiens_hsa052170.39763857
120Arachidonic acid metabolism_Homo sapiens_hsa005900.38180730
121Bile secretion_Homo sapiens_hsa049760.37585548
122Renal cell carcinoma_Homo sapiens_hsa052110.37193483
123Cholinergic synapse_Homo sapiens_hsa047250.37112327
124Axon guidance_Homo sapiens_hsa043600.36285299
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35768305
126Prostate cancer_Homo sapiens_hsa052150.35255035
127Melanogenesis_Homo sapiens_hsa049160.35069006
128Thyroid hormone synthesis_Homo sapiens_hsa049180.34656139
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33674548
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33181163
131ErbB signaling pathway_Homo sapiens_hsa040120.32701854
132Estrogen signaling pathway_Homo sapiens_hsa049150.32659443
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31966807
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31756173
135Small cell lung cancer_Homo sapiens_hsa052220.30663922
136Galactose metabolism_Homo sapiens_hsa000520.30389684
137Vibrio cholerae infection_Homo sapiens_hsa051100.30133288
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29494743
139HTLV-I infection_Homo sapiens_hsa051660.27648895
140Amoebiasis_Homo sapiens_hsa051460.27619274
141Pancreatic cancer_Homo sapiens_hsa052120.26343298
142cAMP signaling pathway_Homo sapiens_hsa040240.25635780
143Rap1 signaling pathway_Homo sapiens_hsa040150.24212788
144Serotonergic synapse_Homo sapiens_hsa047260.23817491
145Amphetamine addiction_Homo sapiens_hsa050310.19862004
146GnRH signaling pathway_Homo sapiens_hsa049120.19753883
147MicroRNAs in cancer_Homo sapiens_hsa052060.19688186
148mTOR signaling pathway_Homo sapiens_hsa041500.19540799
149Choline metabolism in cancer_Homo sapiens_hsa052310.19487103
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19113281
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.18841896
152Long-term potentiation_Homo sapiens_hsa047200.18513392

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