COL11A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cartilage condensation (GO:0001502)9.70019357
2* cell aggregation (GO:0098743)9.70019357
3notochord development (GO:0030903)8.87571095
4limb bud formation (GO:0060174)8.84980124
5* chondrocyte development (GO:0002063)8.60298390
6positive regulation of extracellular matrix organization (GO:1903055)8.06166731
7negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)8.02272935
8* collagen fibril organization (GO:0030199)7.21354461
9cartilage development (GO:0051216)6.49492559
10embryonic skeletal joint morphogenesis (GO:0060272)6.45028935
11chondroitin sulfate biosynthetic process (GO:0030206)6.06285009
12sphingomyelin metabolic process (GO:0006684)5.98458639
13endochondral ossification (GO:0001958)5.98075134
14replacement ossification (GO:0036075)5.98075134
15chondrocyte differentiation (GO:0002062)5.49803362
16protein retention in ER lumen (GO:0006621)5.40286186
17endothelial cell morphogenesis (GO:0001886)5.37405927
18nucleotide-sugar biosynthetic process (GO:0009226)5.36871287
19regulation of extracellular matrix disassembly (GO:0010715)5.19788141
20* collagen catabolic process (GO:0030574)5.16062078
21positive regulation of chondrocyte differentiation (GO:0032332)5.13921140
22* proteoglycan metabolic process (GO:0006029)5.13884792
23keratan sulfate biosynthetic process (GO:0018146)5.13198749
24protein heterotrimerization (GO:0070208)5.12426339
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.04717241
26skeletal system development (GO:0001501)5.01201478
27* collagen metabolic process (GO:0032963)4.95802976
28peptidyl-proline hydroxylation (GO:0019511)4.89165651
29regulation of extracellular matrix organization (GO:1903053)4.71384244
30* multicellular organismal catabolic process (GO:0044243)4.70780453
31cellular glucuronidation (GO:0052695)4.70232834
32* multicellular organismal macromolecule metabolic process (GO:0044259)4.62527356
33positive regulation of cartilage development (GO:0061036)4.58659201
34iron ion import (GO:0097286)4.56011973
35negative regulation of gluconeogenesis (GO:0045721)4.50669747
36* multicellular organismal metabolic process (GO:0044236)4.39999088
37hypotonic response (GO:0006971)4.33961091
38lipopolysaccharide biosynthetic process (GO:0009103)4.29023895
39cellular response to BMP stimulus (GO:0071773)4.26809702
40response to BMP (GO:0071772)4.26809702
41short-term memory (GO:0007614)4.24426615
42endocardial cushion morphogenesis (GO:0003203)4.23031682
43regulation of plasminogen activation (GO:0010755)4.20878588
44uronic acid metabolic process (GO:0006063)4.19503284
45glucuronate metabolic process (GO:0019585)4.19503284
46keratan sulfate metabolic process (GO:0042339)4.16105512
47planar cell polarity pathway involved in neural tube closure (GO:0090179)4.09347122
48chondrocyte proliferation (GO:0035988)4.08224085
49* extracellular matrix disassembly (GO:0022617)4.08100046
50metanephric mesenchyme development (GO:0072075)4.06116843
51glycosaminoglycan biosynthetic process (GO:0006024)4.04883430
52negative regulation of smooth muscle cell differentiation (GO:0051151)4.03091272
53cell migration involved in heart development (GO:0060973)4.00527678
54regulation of chondrocyte differentiation (GO:0032330)3.99574402
55aminoglycan biosynthetic process (GO:0006023)3.99419877
56basement membrane organization (GO:0071711)3.96320649
57extracellular fibril organization (GO:0043206)3.92961105
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.89284854
59protein hydroxylation (GO:0018126)3.86910922
60kidney mesenchyme development (GO:0072074)3.86499305
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.86120034
62* endodermal cell differentiation (GO:0035987)3.86003570
63response to gravity (GO:0009629)3.84535552
64chondroitin sulfate metabolic process (GO:0030204)3.79814040
65regulation of establishment of planar polarity (GO:0090175)3.76018899
66bone trabecula formation (GO:0060346)3.75313018
67regulation of cartilage development (GO:0061035)3.73852320
68UDP-N-acetylglucosamine metabolic process (GO:0006047)3.71389112
69myelin assembly (GO:0032288)3.71233284
70neuron projection extension involved in neuron projection guidance (GO:1902284)3.71166690
71axon extension involved in axon guidance (GO:0048846)3.71166690
72regulation of type B pancreatic cell apoptotic process (GO:2000674)3.68134057
73establishment of planar polarity (GO:0001736)3.68020028
74establishment of tissue polarity (GO:0007164)3.68020028
75positive regulation of hormone biosynthetic process (GO:0046886)3.65371695
76ossification (GO:0001503)3.65254207
77glycosaminoglycan catabolic process (GO:0006027)3.64231304
78paraxial mesoderm development (GO:0048339)3.62037749
79lipopolysaccharide metabolic process (GO:0008653)3.57812462
80COPII vesicle coating (GO:0048208)3.56798844
81sequestering of extracellular ligand from receptor (GO:0035581)3.56021672
82cochlea morphogenesis (GO:0090103)3.51945733
83skin morphogenesis (GO:0043589)3.49545385
84outer ear morphogenesis (GO:0042473)3.47567463
85* extracellular matrix organization (GO:0030198)3.46025849
86* extracellular structure organization (GO:0043062)3.45204069
87mesenchyme morphogenesis (GO:0072132)3.43763343
88aminoglycan catabolic process (GO:0006026)3.41427103
89sulfur compound catabolic process (GO:0044273)3.41033134
90mesenchymal-epithelial cell signaling (GO:0060638)3.39248151
91lateral sprouting from an epithelium (GO:0060601)3.38962851
92camera-type eye morphogenesis (GO:0048593)3.38478334
93* glycoprotein metabolic process (GO:0009100)3.33506634
94negative regulation of cartilage development (GO:0061037)3.29841420
95convergent extension (GO:0060026)3.29490029
96proteoglycan biosynthetic process (GO:0030166)3.27613698
97regulation of bone mineralization (GO:0030500)3.27609554
98regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.26964421
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.26706943
100negative regulation of embryonic development (GO:0045992)3.23101294
101non-canonical Wnt signaling pathway (GO:0035567)3.22951402
102embryonic viscerocranium morphogenesis (GO:0048703)3.22515324
103COPI coating of Golgi vesicle (GO:0048205)3.22377783
104Golgi transport vesicle coating (GO:0048200)3.22377783
105negative regulation of chondrocyte differentiation (GO:0032331)3.21658555
106cell migration involved in sprouting angiogenesis (GO:0002042)3.13652788
107wound healing, spreading of epidermal cells (GO:0035313)3.13569165
108negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.10695624
109craniofacial suture morphogenesis (GO:0097094)3.10552955
110regulation of integrin-mediated signaling pathway (GO:2001044)3.09148625
111mucopolysaccharide metabolic process (GO:1903510)3.07718609
112otic vesicle formation (GO:0030916)3.07501124
113regulation of cell maturation (GO:1903429)3.07399827
114fibril organization (GO:0097435)3.07322748
115negative chemotaxis (GO:0050919)3.05048171
116G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.02966089
117glomerular basement membrane development (GO:0032836)3.02078917
118regulation of axon extension involved in axon guidance (GO:0048841)3.01276443
119regulation of biomineral tissue development (GO:0070167)3.00176999
120nucleotide-sugar metabolic process (GO:0009225)2.99669685
121negative regulation of glycogen biosynthetic process (GO:0045719)2.99533810
122regulation of steroid hormone biosynthetic process (GO:0090030)2.95873096
123negative regulation of axon extension involved in axon guidance (GO:0048843)2.93988549
124regulation of non-canonical Wnt signaling pathway (GO:2000050)2.93827133
125cell adhesion mediated by integrin (GO:0033627)2.92259413
126negative regulation of endothelial cell proliferation (GO:0001937)2.91899574
127bone development (GO:0060348)2.91793956
128regulation of axon guidance (GO:1902667)2.91708634
129regulation of cardioblast differentiation (GO:0051890)2.91599866
130regulation of transforming growth factor beta2 production (GO:0032909)2.91330141
131vascular endothelial growth factor signaling pathway (GO:0038084)2.91104633
132regulation of response to osmotic stress (GO:0047484)2.90938545
133positive regulation of epithelial to mesenchymal transition (GO:0010718)2.89492807
134* connective tissue development (GO:0061448)2.89210368
135presynaptic membrane assembly (GO:0097105)2.88244191
136radial glial cell differentiation (GO:0060019)2.87625653
137epithelial to mesenchymal transition (GO:0001837)2.86725009
138positive regulation of stem cell differentiation (GO:2000738)2.86679493
139positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.85756769
140positive regulation of male gonad development (GO:2000020)2.83887458
141pericardium development (GO:0060039)2.83182528
142dermatan sulfate biosynthetic process (GO:0030208)2.82654458
143positive regulation of osteoblast proliferation (GO:0033690)2.82282041
144eye morphogenesis (GO:0048592)2.81535647
145retina vasculature morphogenesis in camera-type eye (GO:0061299)2.80677361
146negative regulation of axon guidance (GO:1902668)2.80527007
147negative regulation of glycogen metabolic process (GO:0070874)2.79651836
148positive regulation of smoothened signaling pathway (GO:0045880)2.78888243
149axon extension (GO:0048675)2.76441640
150artery development (GO:0060840)2.73873802
151wound healing, spreading of cells (GO:0044319)2.73642476
152myoblast fusion (GO:0007520)2.73005290
153dermatan sulfate metabolic process (GO:0030205)2.71093504
154tooth mineralization (GO:0034505)2.68205933
155axonal fasciculation (GO:0007413)2.67554564
156substrate-dependent cell migration (GO:0006929)2.65539381
157embryonic cranial skeleton morphogenesis (GO:0048701)2.64624184
158positive regulation of mesenchymal cell proliferation (GO:0002053)2.64613113
159hippo signaling (GO:0035329)2.64309955
160mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.63799786
161Notch signaling involved in heart development (GO:0061314)2.62840511
162neuron recognition (GO:0008038)2.61083446
163neural crest cell development (GO:0014032)2.60485488
164protein localization to cell surface (GO:0034394)2.58813588
165cellular response to amino acid stimulus (GO:0071230)2.58128064
166cerebral cortex radially oriented cell migration (GO:0021799)2.53926295
167cell surface receptor signaling pathway involved in heart development (GO:0061311)2.52185588
168face morphogenesis (GO:0060325)2.51436744
169postsynaptic membrane organization (GO:0001941)2.50276793
170dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.50102583
171substrate adhesion-dependent cell spreading (GO:0034446)2.49667767
172presynaptic membrane organization (GO:0097090)2.49381514
173regulation of mesenchymal cell proliferation (GO:0010464)2.48740018
174cartilage development involved in endochondral bone morphogenesis (GO:0060351)13.8549886
175keratan sulfate catabolic process (GO:0042340)10.8588396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.49338264
2AR_21572438_ChIP-Seq_LNCaP_Human5.39161862
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.78549910
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.84467863
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.46395201
6GATA1_22025678_ChIP-Seq_K562_Human3.34377475
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.96861043
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.87706864
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62939887
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.60289135
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55590672
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.35801967
13CJUN_26792858_Chip-Seq_BT549_Human2.23392893
14EZH2_22144423_ChIP-Seq_EOC_Human2.22157324
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.19328001
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.16089949
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.05872674
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00683657
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.97058653
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93889374
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.92023999
22TP53_18474530_ChIP-ChIP_U2OS_Human1.88610261
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.87814253
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78551814
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76188900
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75508609
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71238929
28TP53_16413492_ChIP-PET_HCT116_Human1.71024313
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69384263
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.68314388
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64418658
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64414166
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64414166
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56516998
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56516998
36RXR_22108803_ChIP-Seq_LS180_Human1.56426830
37* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56185601
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55655166
39* ISL1_27105846_Chip-Seq_CPCs_Mouse1.55333551
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52249982
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51189421
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51070566
43* CBX2_27304074_Chip-Seq_ESCs_Mouse1.48769953
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48644370
45BRD4_25478319_ChIP-Seq_HGPS_Human1.45976679
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45375540
47JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42930994
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42535728
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.41936765
50SMAD4_21799915_ChIP-Seq_A2780_Human1.41190051
51* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39628690
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39563494
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38102071
54TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37612350
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37274776
56TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37092421
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35187853
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31913381
59SOX2_20726797_ChIP-Seq_SW620_Human1.31665172
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30256355
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29909586
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29885461
63VDR_24787735_ChIP-Seq_THP-1_Human1.28826445
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.28797824
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27754389
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.25925769
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25842064
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.25189519
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24711475
70TAF15_26573619_Chip-Seq_HEK293_Human1.24517201
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23779454
72CLOCK_20551151_ChIP-Seq_293T_Human1.22719312
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22643173
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21893288
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20783274
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20783274
77* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19895934
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19777272
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19716384
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18779812
81* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18661968
82FUS_26573619_Chip-Seq_HEK293_Human1.18163284
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.16362928
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15459075
85* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13855528
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.13172585
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12881829
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12585240
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12107147
90GATA3_24758297_ChIP-Seq_MCF-7_Human1.11847178
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10759996
92SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10730846
93PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10612053
94SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10428247
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10366904
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.09640642
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.09351537
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08179853
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07802113
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07559402
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07559402
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06425134
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06397558
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06378803
105EWS_26573619_Chip-Seq_HEK293_Human1.04871487
106* SOX9_26525672_Chip-Seq_HEART_Mouse1.04703528
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.04042402
108RNF2_27304074_Chip-Seq_ESCs_Mouse1.03610229
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03600850
110CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03298496
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02835446
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.02363094
113RNF2_27304074_Chip-Seq_NSC_Mouse1.02265500
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02245209
115GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01380957
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01208847
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01202399
118* SA1_22415368_ChIP-Seq_MEFs_Mouse1.01183439
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99976935
120* KDM2B_26808549_Chip-Seq_REH_Human0.98722297
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97649541
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97514845
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97396831
124AR_25329375_ChIP-Seq_VCAP_Human0.95970251
125EGR1_19032775_ChIP-ChIP_M12_Human0.95180670
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94979436
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94180300
128TCF4_22108803_ChIP-Seq_LS180_Human0.93968686
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93370852
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.93315155
131GBX2_23144817_ChIP-Seq_PC3_Human0.92897518
132* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92144179
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91280370
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.90445254
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90290423
136* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90213209
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88169212
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85923528
139* NANOG_18555785_Chip-Seq_ESCs_Mouse0.85400420
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85280770
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84837511
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.84781886
143TP63_23658742_ChIP-Seq_EP156T_Human0.84628011
144P300_19829295_ChIP-Seq_ESCs_Human0.82871834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004134_abnormal_chest_morphology6.02929562
2MP0002933_joint_inflammation5.77410113
3MP0005503_abnormal_tendon_morphology5.20522241
4MP0009250_abnormal_appendicular_skeleto4.22966170
5* MP0002282_abnormal_trachea_morphology4.12665435
6* MP0000163_abnormal_cartilage_morphology3.93813666
7MP0003646_muscle_fatigue3.56283971
8MP0005257_abnormal_intraocular_pressure3.49798595
9MP0009780_abnormal_chondrocyte_physiolo3.33483899
10* MP0002115_abnormal_skeleton_extremities3.31812851
11MP0008438_abnormal_cutaneous_collagen3.11613497
12MP0001299_abnormal_eye_distance/2.82200777
13MP0003123_paternal_imprinting2.80682479
14MP0002089_abnormal_postnatal_growth/wei2.77546032
15* MP0002113_abnormal_skeleton_development2.76675667
16MP0005508_abnormal_skeleton_morphology2.63863777
17MP0005171_absent_coat_pigmentation2.58383874
18MP0005390_skeleton_phenotype2.42207727
19MP0001533_abnormal_skeleton_physiology2.33925754
20MP0009384_cardiac_valve_regurgitation2.32397346
21MP0005275_abnormal_skin_tensile2.31180864
22* MP0002896_abnormal_bone_mineralization2.24227666
23MP0001270_distended_abdomen2.21338133
24MP0001542_abnormal_bone_strength2.17438127
25MP0002909_abnormal_adrenal_gland2.15607868
26* MP0002109_abnormal_limb_morphology2.14584451
27MP0004272_abnormal_basement_membrane1.87165024
28MP0003283_abnormal_digestive_organ1.83614586
29MP0003279_aneurysm1.78048744
30* MP0003795_abnormal_bone_structure1.76945037
31MP0010368_abnormal_lymphatic_system1.76238137
32MP0000537_abnormal_urethra_morphology1.74912391
33* MP0000762_abnormal_tongue_morphology1.74106713
34MP0000049_abnormal_middle_ear1.69043200
35MP0000751_myopathy1.66226108
36* MP0002116_abnormal_craniofacial_bone1.62281665
37MP0002108_abnormal_muscle_morphology1.61768447
38MP0002938_white_spotting1.59225025
39* MP0003755_abnormal_palate_morphology1.58222957
40MP0003787_abnormal_imprinting1.55172511
41MP0002163_abnormal_gland_morphology1.54686614
42MP0003705_abnormal_hypodermis_morpholog1.47052465
43MP0003656_abnormal_erythrocyte_physiolo1.46066569
44MP0003136_yellow_coat_color1.43852338
45MP0000778_abnormal_nervous_system1.42821659
46MP0002233_abnormal_nose_morphology1.39613435
47MP0008004_abnormal_stomach_pH1.37253188
48MP0002249_abnormal_larynx_morphology1.35036131
49MP0003937_abnormal_limbs/digits/tail_de1.31387081
50MP0010030_abnormal_orbit_morphology1.29808009
51MP0002998_abnormal_bone_remodeling1.28370190
52* MP0000432_abnormal_head_morphology1.28204604
53MP0002697_abnormal_eye_size1.26401036
54MP0005023_abnormal_wound_healing1.26074777
55MP0002111_abnormal_tail_morphology1.25521685
56MP0003566_abnormal_cell_adhesion1.21122047
57MP0003385_abnormal_body_wall1.19755741
58MP0000767_abnormal_smooth_muscle1.15670811
59* MP0002114_abnormal_axial_skeleton1.11008387
60MP0005197_abnormal_uvea_morphology1.09479348
61MP0001958_emphysema1.07937790
62MP0000569_abnormal_digit_pigmentation1.07778400
63MP0003122_maternal_imprinting1.07662411
64MP0001879_abnormal_lymphatic_vessel1.06525197
65MP0005187_abnormal_penis_morphology1.05733343
66MP0004197_abnormal_fetal_growth/weight/1.05364253
67MP0003121_genomic_imprinting1.05076475
68MP0003091_abnormal_cell_migration1.04583414
69MP0000343_altered_response_to1.03386984
70MP0001663_abnormal_digestive_system1.03366791
71MP0004858_abnormal_nervous_system1.03364399
72MP0005381_digestive/alimentary_phenotyp1.03047266
73MP0003942_abnormal_urinary_system1.01652786
74MP0002932_abnormal_joint_morphology1.01597053
75MP0001293_anophthalmia1.01502348
76* MP0003935_abnormal_craniofacial_develop1.00305923
77MP0004885_abnormal_endolymph0.97015349
78MP0004859_abnormal_synaptic_plasticity0.97013337
79MP0003436_decreased_susceptibility_to0.96764084
80MP0002092_abnormal_eye_morphology0.96307425
81MP0002102_abnormal_ear_morphology0.93741640
82MP0005164_abnormal_response_to0.91680615
83MP0004484_altered_response_of0.90311799
84MP0004084_abnormal_cardiac_muscle0.87919928
85MP0000733_abnormal_muscle_development0.84328548
86MP0002177_abnormal_outer_ear0.83461378
87MP0000428_abnormal_craniofacial_morphol0.82901310
88MP0001849_ear_inflammation0.82841907
89MP0001963_abnormal_hearing_physiology0.81340097
90MP0000013_abnormal_adipose_tissue0.80624367
91MP0000749_muscle_degeneration0.77468839
92MP0005408_hypopigmentation0.77354864
93MP0009697_abnormal_copulation0.76429434
94MP0003195_calcinosis0.76103094
95MP0003878_abnormal_ear_physiology0.73531829
96MP0005377_hearing/vestibular/ear_phenot0.73531829
97MP0000566_synostosis0.72374957
98MP0002877_abnormal_melanocyte_morpholog0.72205934
99MP0005623_abnormal_meninges_morphology0.71445357
100MP0000372_irregular_coat_pigmentation0.70915197
101MP0001243_abnormal_dermal_layer0.68665650
102MP0005391_vision/eye_phenotype0.68298697
103MP0003861_abnormal_nervous_system0.67403011
104MP0001177_atelectasis0.67094221
105MP0006292_abnormal_olfactory_placode0.67059924
106MP0005595_abnormal_vascular_smooth0.66796935
107MP0003115_abnormal_respiratory_system0.66769737
108MP0002128_abnormal_blood_circulation0.65233053
109MP0001286_abnormal_eye_development0.64758134
110MP0001915_intracranial_hemorrhage0.64453146
111MP0002060_abnormal_skin_morphology0.64396044
112MP0005248_abnormal_Harderian_gland0.63989735
113MP0000462_abnormal_digestive_system0.62948354
114* MP0002081_perinatal_lethality0.61792978
115MP0000955_abnormal_spinal_cord0.60965100
116MP0005076_abnormal_cell_differentiation0.60062486
117MP0003941_abnormal_skin_development0.58869233
118MP0005379_endocrine/exocrine_gland_phen0.57440023
119MP0000534_abnormal_ureter_morphology0.56966963
120MP0000465_gastrointestinal_hemorrhage0.54629882
121MP0003119_abnormal_digestive_system0.48129081
122MP0000026_abnormal_inner_ear0.47381955
123MP0006054_spinal_hemorrhage0.46681440
124MP0002295_abnormal_pulmonary_circulatio0.45983077
125* MP0001943_abnormal_respiration0.44965749
126MP0001340_abnormal_eyelid_morphology0.44556978
127MP0002735_abnormal_chemical_nociception0.44191453
128MP0008775_abnormal_heart_ventricle0.44122355
129MP0009053_abnormal_anal_canal0.42932107
130MP0000516_abnormal_urinary_system0.42293930
131MP0005367_renal/urinary_system_phenotyp0.42293930
132MP0005166_decreased_susceptibility_to0.41047998
133MP0003448_altered_tumor_morphology0.39326886
134MP0005193_abnormal_anterior_eye0.38533877
135MP0002234_abnormal_pharynx_morphology0.36431669
136MP0001175_abnormal_lung_morphology0.35582796
137MP0003950_abnormal_plasma_membrane0.32650735

Predicted human phenotypes

RankGene SetZ-score
1* Irregular epiphyses (HP:0010582)8.81073902
2Small epiphyses (HP:0010585)7.08117981
3Abnormal tarsal ossification (HP:0008369)6.47906091
4* Vitreoretinal degeneration (HP:0000655)6.43804888
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)6.31762348
6Protrusio acetabuli (HP:0003179)6.21128487
7Flat capital femoral epiphysis (HP:0003370)6.00896953
8Aortic dissection (HP:0002647)5.89365652
9Flat acetabular roof (HP:0003180)5.66701579
10Delayed epiphyseal ossification (HP:0002663)5.56377130
11Genu varum (HP:0002970)5.53396242
12Soft skin (HP:0000977)5.35899792
13* Cupped ribs (HP:0000887)5.28228244
14* Hypoplastic ischia (HP:0003175)5.20099373
15Atrophic scars (HP:0001075)4.94734853
16Neonatal short-limb short stature (HP:0008921)4.92579167
17Metaphyseal cupping (HP:0003021)4.92432911
18Flattened epiphyses (HP:0003071)4.88603075
19Abnormal foot bone ossification (HP:0010675)4.82632090
20Absent epiphyses (HP:0010577)4.67257176
21Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.67257176
22Abnormality of the vertebral endplates (HP:0005106)4.64296428
23* Abnormality of the ischium (HP:0003174)4.57535047
24Mild short stature (HP:0003502)4.55901545
25Bladder diverticulum (HP:0000015)4.36552432
26Abnormality of the epiphysis of the femoral head (HP:0010574)4.35278665
27Abnormality of dentin (HP:0010299)4.26530812
28Genu recurvatum (HP:0002816)4.22781501
29* Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.21022762
30* Abnormality of femoral epiphyses (HP:0006499)4.21022762
31Peritonitis (HP:0002586)4.18891849
32Vascular tortuosity (HP:0004948)4.11756351
33Short femoral neck (HP:0100864)4.09691074
34Metaphyseal dysplasia (HP:0100255)4.02756689
35Abnormality of the femoral head (HP:0003368)4.01840611
36* Osteoarthritis (HP:0002758)3.96952898
37Irregular vertebral endplates (HP:0003301)3.95459573
38Arterial tortuosity (HP:0005116)3.84867653
39Metaphyseal irregularity (HP:0003025)3.83820917
40Fragile skin (HP:0001030)3.77020926
41Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.74868056
42Abnormality of the pubic bones (HP:0003172)3.67024175
43Aortic aneurysm (HP:0004942)3.63445434
44Coxa vara (HP:0002812)3.58029786
45Mitral valve prolapse (HP:0001634)3.54053539
46Cervical subluxation (HP:0003308)3.43675464
47Enlarged epiphyses (HP:0010580)3.42048748
48Abnormality of the phalanges of the 2nd finger (HP:0009541)3.41008735
49Abnormal vertebral ossification (HP:0100569)3.38535378
50Abnormality of the proximal phalanges of the hand (HP:0009834)3.35834907
51Abnormality of carpal bone ossification (HP:0006257)3.34628284
52Infantile muscular hypotonia (HP:0008947)3.32280739
53Morphological abnormality of the middle ear (HP:0008609)3.31405403
54* Wide anterior fontanel (HP:0000260)3.23454813
55Bowel diverticulosis (HP:0005222)3.17491016
56Shallow orbits (HP:0000586)3.15527080
57Thoracolumbar scoliosis (HP:0002944)3.13410256
58Barrel-shaped chest (HP:0001552)3.11360575
59Waddling gait (HP:0002515)3.10156824
60Limited elbow extension (HP:0001377)3.09418433
61Beaking of vertebral bodies (HP:0004568)3.06289746
62* Platyspondyly (HP:0000926)3.04929200
63Vertebral clefting (HP:0008428)3.03324647
64Hyperextensible skin (HP:0000974)2.98938879
65Ovoid vertebral bodies (HP:0003300)2.97746413
66Biconcave vertebral bodies (HP:0004586)2.96306635
67Aplasia/hypoplasia of the femur (HP:0005613)2.94684425
68Wormian bones (HP:0002645)2.87717704
69Spondylolisthesis (HP:0003302)2.87603739
70Exostoses (HP:0100777)2.87238143
71Dilatation of the ascending aorta (HP:0005111)2.87176322
72Blue sclerae (HP:0000592)2.86067426
73Broad metatarsal (HP:0001783)2.86057817
74Limited hip movement (HP:0008800)2.83676247
75Cerebral aneurysm (HP:0004944)2.81590931
76Breech presentation (HP:0001623)2.78998355
77Abnormal hand bone ossification (HP:0010660)2.74202967
78Glossoptosis (HP:0000162)2.70321879
79Hip contracture (HP:0003273)2.68005927
80Hypoplasia of the iris (HP:0007676)2.65903363
81Lumbar hyperlordosis (HP:0002938)2.65724400
82Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.65532838
83Abnormal ossification of hand bones (HP:0005921)2.65457270
84Abnormal delivery (HP:0001787)2.65003952
85Carpal bone hypoplasia (HP:0001498)2.62716495
86Hypoplasia of the odontoid process (HP:0003311)2.61750650
87Spinal cord compression (HP:0002176)2.55540929
88Tibial bowing (HP:0002982)2.52168060
89Mesomelia (HP:0003027)2.51592197
90Ankle contracture (HP:0006466)2.48901132
91Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.48467048
92Hypoplastic pelvis (HP:0008839)2.43332521
93Abnormality of the lumbar spine (HP:0100712)2.42068115
94Aortic regurgitation (HP:0001659)2.41677357
95Calcaneovalgus deformity (HP:0001848)2.41548180
96Follicular hyperkeratosis (HP:0007502)2.40471752
97Joint laxity (HP:0001388)2.38252348
98Abnormality of the 2nd finger (HP:0004100)2.37755507
99* Arthropathy (HP:0003040)2.35047346
100* Protuberant abdomen (HP:0001538)2.33532633
101Decreased skull ossification (HP:0004331)2.31209155
102Deformed tarsal bones (HP:0008119)2.29367480
103Abnormality of the acetabulum (HP:0003170)2.28647826
104Disproportionate short-trunk short stature (HP:0003521)2.27808016
105Abnormality of the phalanges of the 5th finger (HP:0004213)2.24976094
106Mitral regurgitation (HP:0001653)2.24791287
107* Ectopia lentis (HP:0001083)2.24486911
108Coronal craniosynostosis (HP:0004440)2.23652109
109Short middle phalanx of finger (HP:0005819)2.22770270
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21937313
111Short 4th metacarpal (HP:0010044)2.21937313
112Abnormality of the odontoid process (HP:0003310)2.18671326
113Overgrowth (HP:0001548)2.18219552
114Mixed hearing impairment (HP:0000410)2.18194673
115Femoral bowing (HP:0002980)2.18187205
116* Micromelia (HP:0002983)2.16025830
117Relative macrocephaly (HP:0004482)2.12666970
118Flared metaphyses (HP:0003015)2.10255617
119Keratoconus (HP:0000563)2.09236178
120Increased corneal curvature (HP:0100692)2.09236178
121Deviation of the hallux (HP:0010051)2.08415978
122Abnormality of the calcaneus (HP:0008364)2.08410377
123Abnormality of skull ossification (HP:0002703)2.08009064
124Severe Myopia (HP:0011003)2.07162578
125Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.01986740
126* Absent frontal sinuses (HP:0002688)2.01745804
127* Abnormality of the vitreous humor (HP:0004327)2.01227295
128Nonimmune hydrops fetalis (HP:0001790)2.00744085
129Epiphyseal dysplasia (HP:0002656)10.5941330
130Hallux valgus (HP:0001822)1.98233799
131Broad thumb (HP:0011304)1.98089686
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97103576
133* Stillbirth (HP:0003826)1.95279035
134Inguinal hernia (HP:0000023)1.94938323
135Type 1 muscle fiber predominance (HP:0003803)1.94724807
136Turricephaly (HP:0000262)1.91013521
137Joint stiffness (HP:0001387)1.90259135
138Broad ribs (HP:0000885)1.89975066
139Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.84654661
140Venous insufficiency (HP:0005293)1.84414896
141Abnormality of the middle phalanges of the hand (HP:0009833)1.83574002
142Broad phalanges of the hand (HP:0009768)1.80811577
143Tracheomalacia (HP:0002779)1.79915463
144Delayed gross motor development (HP:0002194)1.79889174
145Abnormal cartilage morphology (HP:0002763)1.79451244
146Partial duplication of the phalanx of hand (HP:0009999)1.79126402
147Cutaneous finger syndactyly (HP:0010554)1.78878548
148Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.78124276
149Renal duplication (HP:0000075)1.77671670
150Abnormality of the middle phalanges of the toes (HP:0010183)1.76472095
151* Broad phalanx (HP:0006009)1.75729232
152Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74945318
153* Genu valgum (HP:0002857)1.74791445
154Abnormality of the wing of the ilium (HP:0011867)1.74394959
155Broad finger (HP:0001500)1.74340576
156* Thin ribs (HP:0000883)1.73918842
157* Broad long bones (HP:0005622)1.71930517
158* Ulnar bowing (HP:0003031)1.69548826
159Premature rupture of membranes (HP:0001788)1.69308910
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.68021683
161Osteolytic defects of the hand bones (HP:0009699)1.68021683
162Short 5th finger (HP:0009237)1.67999667
163Camptodactyly of toe (HP:0001836)1.67376446
164Spinal rigidity (HP:0003306)1.66628320
165Hypoplastic iliac wings (HP:0002866)1.66186349
166Bifid tongue (HP:0010297)1.65224796
167Vertebral arch anomaly (HP:0008438)1.64092127
168* Hypoplastic ilia (HP:0000946)1.62707399
169Disproportionate tall stature (HP:0001519)1.62289959
170Cutaneous syndactyly (HP:0012725)1.62217523
171Renovascular hypertension (HP:0100817)1.60031232
172Delayed cranial suture closure (HP:0000270)1.59760518
173Mitral stenosis (HP:0001718)1.59545878
174Abnormality of the 4th metacarpal (HP:0010012)1.57777422
175Pulmonary artery stenosis (HP:0004415)1.56149959
176Spinal cord lesions (HP:0100561)1.53687943
177Syringomyelia (HP:0003396)1.53687943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.91211264
2MAP3K36.88827034
3STK38L4.46827397
4STK244.05462538
5NME13.92428735
6PRKG23.58530204
7TNIK3.57503505
8NTRK13.47323782
9PDGFRA3.35791109
10ERBB32.62429590
11MST42.53483847
12MARK12.34904744
13MYLK2.19574182
14CASK2.16752043
15PNCK2.08618572
16PRKD32.06359479
17PLK22.01191802
18LATS11.96601249
19SIK11.65291386
20TRPM71.61291622
21STK31.58595739
22NUAK11.57704763
23MKNK21.54432355
24DYRK1A1.50204323
25FLT31.41526978
26NTRK21.39846761
27MOS1.28779197
28FGFR21.27312686
29CAMK1G1.19567493
30PAK61.14587763
31TAOK11.13465270
32EPHB21.11863528
33PIM21.09710496
34TYRO31.08300473
35NEK61.08270964
36PIK3CA1.07530188
37EIF2AK31.07466738
38ROCK11.01005341
39PAK41.00791841
40MAPK70.98711509
41PDK20.97674013
42MAPK120.97185220
43EPHA20.95671378
44WEE10.95275479
45DMPK0.94847765
46MKNK10.93259776
47NME20.92069469
48MET0.91929780
49CSNK1G20.91364308
50MAP3K100.91326628
51CAMKK20.90878769
52BMPR1B0.84546694
53TIE10.84167705
54GSK3A0.79862573
55MAP3K60.74855275
56BRD40.74267717
57AKT30.72365609
58PIK3CG0.69773593
59RIPK10.69352709
60TRIB30.68873535
61MAPK40.66064327
62NEK20.62438043
63ERBB20.60488036
64BCR0.58618137
65FGFR10.57445230
66STK380.55371045
67CDK60.54962184
68PLK30.54295190
69LIMK10.54195344
70WNK40.53563095
71EIF2AK10.53206129
72TAOK20.52963743
73TGFBR10.52203587
74CDK180.47948426
75LATS20.46287370
76DYRK20.46262178
77MAPK150.46141414
78CDK150.46071046
79WNK10.45160027
80CDK11A0.44762297
81MAP2K30.43891182
82CDK30.43536645
83LMTK20.43381042
84EPHA30.42953765
85FGFR30.42784591
86PRKCH0.42552611
87DYRK1B0.41304065
88CDC42BPA0.40154647
89MAP3K40.39516141
90MINK10.39187537
91CDK140.39168554
92NLK0.38763705
93PBK0.38127580
94UHMK10.37792565
95MAP3K110.37509239
96YES10.37470340
97CDK120.36363032
98STK390.36356570
99EPHA40.35933277
100SRC0.35806673
101MUSK0.35514345
102EIF2AK20.35352491
103PTK2B0.34854624
104RPS6KA20.34348290
105FER0.33567023
106CAMKK10.33302991
107PAK30.32479750
108PRKG10.31854062
109KSR10.31835698
110PKN20.29785922
111PTK20.29619436
112PRKD20.28210043
113PDGFRB0.27535047
114ERBB40.27449898
115TGFBR20.26988404
116PRKACG0.26221459
117CSNK1A1L0.25825384
118PRKCE0.25381164
119TTN0.25144394
120CSNK1G10.25017972
121RPS6KB10.24986034
122TESK10.24872667
123IGF1R0.24558815
124CSF1R0.23459807
125BMX0.23323186
126BRSK20.23290139
127ADRBK10.22653480
128MAPK100.21468063
129ABL10.20788332
130SGK10.20342158
131PRKCD0.20330076
132MAPK10.19589159
133PIM10.19574658
134MAPK30.19477986
135PAK20.19356020
136PRKCI0.16960116
137INSR0.16565315
138ROCK20.14436823
139MAP3K50.13069587
140NEK90.12806430
141PRKACA0.12176744
142BMPR20.11704602
143SIK30.10533773
144CHUK0.09181734
145IKBKB0.08726134
146MTOR0.08709936
147AKT10.08405640
148PRKCG0.08250899
149PRKCA0.07850917

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.48860772
2ECM-receptor interaction_Homo sapiens_hsa045126.72148421
3* Protein digestion and absorption_Homo sapiens_hsa049745.35874720
4Focal adhesion_Homo sapiens_hsa045102.63885179
5Steroid biosynthesis_Homo sapiens_hsa001002.50322638
6Sphingolipid metabolism_Homo sapiens_hsa006002.45890094
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.38769951
8Sulfur metabolism_Homo sapiens_hsa009202.26851233
9PI3K-Akt signaling pathway_Homo sapiens_hsa041511.92465295
10TGF-beta signaling pathway_Homo sapiens_hsa043501.86892200
11Malaria_Homo sapiens_hsa051441.81287936
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78148734
13Olfactory transduction_Homo sapiens_hsa047401.72397807
14Starch and sucrose metabolism_Homo sapiens_hsa005001.54935578
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46918971
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38822403
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36708458
18Protein export_Homo sapiens_hsa030601.36565069
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36485700
20Proteoglycans in cancer_Homo sapiens_hsa052051.35241217
21Other glycan degradation_Homo sapiens_hsa005111.31922174
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31809723
23Tight junction_Homo sapiens_hsa045301.27777193
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27278056
25Hippo signaling pathway_Homo sapiens_hsa043901.25417834
26Basal cell carcinoma_Homo sapiens_hsa052171.20795562
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17403869
28Hedgehog signaling pathway_Homo sapiens_hsa043401.16645641
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05238099
30Notch signaling pathway_Homo sapiens_hsa043301.04769119
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01792775
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00822149
33Ovarian steroidogenesis_Homo sapiens_hsa049130.97881037
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97231902
35Arginine and proline metabolism_Homo sapiens_hsa003300.95168902
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86299875
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84619882
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81744560
39Selenocompound metabolism_Homo sapiens_hsa004500.78596729
40Dorso-ventral axis formation_Homo sapiens_hsa043200.78052482
41Dilated cardiomyopathy_Homo sapiens_hsa054140.77880078
42Wnt signaling pathway_Homo sapiens_hsa043100.75019838
43Endometrial cancer_Homo sapiens_hsa052130.74991518
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.74634754
45Phagosome_Homo sapiens_hsa041450.74592612
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74485543
47Long-term depression_Homo sapiens_hsa047300.71576581
48Vibrio cholerae infection_Homo sapiens_hsa051100.71137986
49p53 signaling pathway_Homo sapiens_hsa041150.68229550
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66580526
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64998979
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62677024
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62092875
54Salivary secretion_Homo sapiens_hsa049700.61500974
55Adherens junction_Homo sapiens_hsa045200.60847530
56Chronic myeloid leukemia_Homo sapiens_hsa052200.58926357
57Gap junction_Homo sapiens_hsa045400.58698100
58Propanoate metabolism_Homo sapiens_hsa006400.58563979
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58309545
60Melanogenesis_Homo sapiens_hsa049160.57016721
61Bladder cancer_Homo sapiens_hsa052190.56606569
62MicroRNAs in cancer_Homo sapiens_hsa052060.54684867
63Glutamatergic synapse_Homo sapiens_hsa047240.54571809
64Amoebiasis_Homo sapiens_hsa051460.54436946
65Nicotine addiction_Homo sapiens_hsa050330.53701602
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.53423508
67Dopaminergic synapse_Homo sapiens_hsa047280.53121300
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51907263
69Thyroid hormone synthesis_Homo sapiens_hsa049180.51333236
70HIF-1 signaling pathway_Homo sapiens_hsa040660.49865920
71Oxytocin signaling pathway_Homo sapiens_hsa049210.49449420
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49340638
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48693559
74Circadian entrainment_Homo sapiens_hsa047130.48037049
75Galactose metabolism_Homo sapiens_hsa000520.47987451
76Lysine degradation_Homo sapiens_hsa003100.46665832
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46600811
78N-Glycan biosynthesis_Homo sapiens_hsa005100.46481857
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.46479713
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46022090
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46003598
82Axon guidance_Homo sapiens_hsa043600.45966288
83Prostate cancer_Homo sapiens_hsa052150.43300774
84FoxO signaling pathway_Homo sapiens_hsa040680.43247823
85Circadian rhythm_Homo sapiens_hsa047100.41197627
86AMPK signaling pathway_Homo sapiens_hsa041520.41060502
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40599630
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39392718
89Choline metabolism in cancer_Homo sapiens_hsa052310.36867881
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36439189
91Platelet activation_Homo sapiens_hsa046110.36005830
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35655027
93Cocaine addiction_Homo sapiens_hsa050300.35544873
94Folate biosynthesis_Homo sapiens_hsa007900.34972117
95Pancreatic cancer_Homo sapiens_hsa052120.34861730
96Estrogen signaling pathway_Homo sapiens_hsa049150.34696954
97Renal cell carcinoma_Homo sapiens_hsa052110.34495245
98Arachidonic acid metabolism_Homo sapiens_hsa005900.33167605
99Prion diseases_Homo sapiens_hsa050200.32565938
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31915731
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.31843214
102Rap1 signaling pathway_Homo sapiens_hsa040150.31448795
103One carbon pool by folate_Homo sapiens_hsa006700.30527183
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.30521969
105Amphetamine addiction_Homo sapiens_hsa050310.30136359
106MAPK signaling pathway_Homo sapiens_hsa040100.30135699
107Small cell lung cancer_Homo sapiens_hsa052220.30031844
108Melanoma_Homo sapiens_hsa052180.29662698
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29592336
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29497836
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29367729
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28957980
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28928272
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.28434380
115HTLV-I infection_Homo sapiens_hsa051660.28256698
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28077161
117Glioma_Homo sapiens_hsa052140.27793271
118Thyroid cancer_Homo sapiens_hsa052160.27723834
119Hepatitis B_Homo sapiens_hsa051610.27669152
120Pathways in cancer_Homo sapiens_hsa052000.27517513
121Inositol phosphate metabolism_Homo sapiens_hsa005620.27220456
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27110990
123mTOR signaling pathway_Homo sapiens_hsa041500.26015996
124cAMP signaling pathway_Homo sapiens_hsa040240.25739330
125Taste transduction_Homo sapiens_hsa047420.24938272
126ErbB signaling pathway_Homo sapiens_hsa040120.24570930
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24048516
128Cholinergic synapse_Homo sapiens_hsa047250.22159713
129Renin secretion_Homo sapiens_hsa049240.20999532
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19343707
131Colorectal cancer_Homo sapiens_hsa052100.19294244
132Ras signaling pathway_Homo sapiens_hsa040140.18325046
133Insulin resistance_Homo sapiens_hsa049310.18176554
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17662819
135Hematopoietic cell lineage_Homo sapiens_hsa046400.17164684

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