COL13A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of one of the nonfibrillar collagens. The function of this gene product is not known, however, it has been detected at low levels in all connective tissue-producing cells so it may serve a general function in connective tissues. Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, collagen XIII is a trimer; it is not known whether this trimer is composed of one or more than one alpha chain isomer. A number of alternatively spliced transcript variants have been described, but the full length nature of some of them has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)5.87458144
2cell adhesion mediated by integrin (GO:0033627)5.52308664
3substrate-dependent cell migration (GO:0006929)5.02724575
4mesodermal cell differentiation (GO:0048333)4.93582241
5L-phenylalanine catabolic process (GO:0006559)4.77403537
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.77403537
7protein maturation by protein folding (GO:0022417)4.72628598
8L-phenylalanine metabolic process (GO:0006558)4.72008510
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.72008510
10protein localization to endosome (GO:0036010)4.57698103
11chondrocyte proliferation (GO:0035988)4.54304862
12negative regulation of fibrinolysis (GO:0051918)4.37186629
13basement membrane organization (GO:0071711)4.34517864
14wound healing, spreading of epidermal cells (GO:0035313)4.30328190
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.22324441
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.21179082
17regulation of fibrinolysis (GO:0051917)4.19745142
18midgut development (GO:0007494)4.19313254
19regulation of endothelial cell differentiation (GO:0045601)4.17611214
20negative regulation of chondrocyte differentiation (GO:0032331)4.13878765
21type B pancreatic cell proliferation (GO:0044342)4.13368498
22protein carboxylation (GO:0018214)4.11761889
23peptidyl-glutamic acid carboxylation (GO:0017187)4.11761889
24endodermal cell differentiation (GO:0035987)4.06123687
25surfactant homeostasis (GO:0043129)4.02316272
26vascular endothelial growth factor signaling pathway (GO:0038084)4.01648551
27blood vessel maturation (GO:0001955)3.98872677
28muscle cell migration (GO:0014812)3.92879600
29endothelial cell chemotaxis (GO:0035767)3.91343144
30positive regulation of endothelial cell differentiation (GO:0045603)3.90300374
31aromatic amino acid family catabolic process (GO:0009074)3.88690023
32hemidesmosome assembly (GO:0031581)3.88614949
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.82748179
34regulation of protein activation cascade (GO:2000257)3.82648005
35Golgi transport vesicle coating (GO:0048200)3.82622065
36COPI coating of Golgi vesicle (GO:0048205)3.82622065
37retina vasculature morphogenesis in camera-type eye (GO:0061299)3.79847842
38homocysteine metabolic process (GO:0050667)3.78292934
39extracellular fibril organization (GO:0043206)3.78174849
40lymphangiogenesis (GO:0001946)3.78112181
41lymph vessel development (GO:0001945)3.76609919
42complement activation, alternative pathway (GO:0006957)3.75958519
43high-density lipoprotein particle remodeling (GO:0034375)3.72136364
44kidney mesenchyme development (GO:0072074)3.68270768
45protein retention in ER lumen (GO:0006621)3.68161638
46polarized epithelial cell differentiation (GO:0030859)3.66657114
47regulation of complement activation (GO:0030449)3.63281056
48bile acid biosynthetic process (GO:0006699)3.62749300
49gap junction assembly (GO:0016264)3.58927330
50hypotonic response (GO:0006971)3.53785282
51sulfur amino acid catabolic process (GO:0000098)3.53520484
52glyoxylate metabolic process (GO:0046487)3.50505826
53wound healing, spreading of cells (GO:0044319)3.47726935
54sequestering of extracellular ligand from receptor (GO:0035581)3.47434087
55lung vasculature development (GO:0060426)3.45926076
56urea cycle (GO:0000050)3.45505648
57urea metabolic process (GO:0019627)3.45505648
58cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.45448657
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.44556107
60alpha-linolenic acid metabolic process (GO:0036109)3.43310437
61endothelial cell morphogenesis (GO:0001886)3.43140428
62cell migration involved in sprouting angiogenesis (GO:0002042)3.36780476
63neuron projection extension involved in neuron projection guidance (GO:1902284)3.33484832
64axon extension involved in axon guidance (GO:0048846)3.33484832
65cell-substrate junction assembly (GO:0007044)3.30704904
66reverse cholesterol transport (GO:0043691)3.30461298
67endothelium development (GO:0003158)3.30022227
68endothelial tube morphogenesis (GO:0061154)3.29348857
69morphogenesis of an endothelium (GO:0003159)3.29348857
70patterning of blood vessels (GO:0001569)3.27875799
71positive regulation of hormone biosynthetic process (GO:0046886)3.27564261
72kynurenine metabolic process (GO:0070189)3.26712230
73actin filament depolymerization (GO:0030042)3.26691892
74cysteine metabolic process (GO:0006534)3.26070208
75blood vessel endothelial cell migration (GO:0043534)3.24757647
76sprouting angiogenesis (GO:0002040)3.24185084
77metanephric mesenchyme development (GO:0072075)3.23248926
78fibril organization (GO:0097435)3.21936555
79protein heterotrimerization (GO:0070208)3.21142689
80glomerular visceral epithelial cell development (GO:0072015)3.20976668
81collagen fibril organization (GO:0030199)3.19987603
82drug catabolic process (GO:0042737)3.19644938
83lysine catabolic process (GO:0006554)3.19107912
84lysine metabolic process (GO:0006553)3.19107912
85positive regulation of fatty acid beta-oxidation (GO:0032000)3.18959330
86positive regulation of osteoblast proliferation (GO:0033690)3.18215626
87indolalkylamine catabolic process (GO:0046218)3.17480150
88tryptophan catabolic process (GO:0006569)3.17480150
89indole-containing compound catabolic process (GO:0042436)3.17480150
90arginine metabolic process (GO:0006525)3.13750334
91bile acid metabolic process (GO:0008206)3.12718640
92heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.08047002
93response to gravity (GO:0009629)3.07968289
94tryptophan metabolic process (GO:0006568)3.06635250
95serine family amino acid catabolic process (GO:0009071)3.06392415
96negative regulation of axon extension involved in axon guidance (GO:0048843)3.06268661
97SMAD protein complex assembly (GO:0007183)3.04794231
98negative regulation of anoikis (GO:2000811)3.04703398
99paraxial mesoderm development (GO:0048339)3.04422364
100barbed-end actin filament capping (GO:0051016)3.03486443
101cortical actin cytoskeleton organization (GO:0030866)3.03036787
102nitrogen cycle metabolic process (GO:0071941)3.02184463
103plasma lipoprotein particle clearance (GO:0034381)3.01871669
104respiratory tube development (GO:0030323)3.00015477
105positive regulation of blood vessel endothelial cell migration (GO:0043536)2.99662326
106establishment of apical/basal cell polarity (GO:0035089)2.99375916
107phospholipid efflux (GO:0033700)2.98614487
108negative regulation of sterol transport (GO:0032372)2.97442577
109negative regulation of cholesterol transport (GO:0032375)2.97442577
110plasma lipoprotein particle remodeling (GO:0034369)2.97131059
111protein-lipid complex remodeling (GO:0034368)2.97131059
112macromolecular complex remodeling (GO:0034367)2.97131059
113vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.96749557
114exogenous drug catabolic process (GO:0042738)2.95141296
115chemical homeostasis within a tissue (GO:0048875)2.95113395
116negative regulation of cartilage development (GO:0061037)2.94816731
117ganglion development (GO:0061548)2.94599009
118regulation of cholesterol esterification (GO:0010872)2.94405122
119planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93776175
120triglyceride homeostasis (GO:0070328)2.93091116
121acylglycerol homeostasis (GO:0055090)2.93091116
122embryonic foregut morphogenesis (GO:0048617)2.92584759
123regulation of triglyceride catabolic process (GO:0010896)2.92580247
124cell migration involved in heart development (GO:0060973)2.92519760
125regulation of cholesterol homeostasis (GO:2000188)2.91667495
126protein hydroxylation (GO:0018126)2.89190592
127establishment of integrated proviral latency (GO:0075713)2.88840401
128cellular response to vitamin (GO:0071295)2.87142389
129cellular response to hepatocyte growth factor stimulus (GO:0035729)2.86752734
130response to hepatocyte growth factor (GO:0035728)2.86752734
131peptidyl-proline hydroxylation (GO:0019511)2.85758715
132tyrosine metabolic process (GO:0006570)2.85204374
133positive regulation of steroid metabolic process (GO:0045940)2.83892299
134cytoskeletal anchoring at plasma membrane (GO:0007016)2.82943551
135arginine catabolic process (GO:0006527)2.82824025
136extracellular negative regulation of signal transduction (GO:1900116)2.82109566
137extracellular regulation of signal transduction (GO:1900115)2.82109566
138negative regulation of hemostasis (GO:1900047)2.77075672
139negative regulation of blood coagulation (GO:0030195)2.77075672
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76340417
141regulation of fatty acid beta-oxidation (GO:0031998)2.75016573
142semaphorin-plexin signaling pathway (GO:0071526)2.74850329
143alpha-amino acid catabolic process (GO:1901606)2.74755973
144bone trabecula formation (GO:0060346)2.74396039
145negative regulation of cell fate specification (GO:0009996)2.74207583
146fibrinolysis (GO:0042730)2.73490311
147regulation of steroid hormone biosynthetic process (GO:0090030)2.73485245
148regulation of glomerular filtration (GO:0003093)2.72819161
149amino-acid betaine metabolic process (GO:0006577)2.72026061
150regulation of bile acid biosynthetic process (GO:0070857)2.71767671
151bile acid and bile salt transport (GO:0015721)2.71429132
152drug metabolic process (GO:0017144)2.71322801
153positive regulation of pseudopodium assembly (GO:0031274)2.71093074
154negative regulation of embryonic development (GO:0045992)2.71010592
155cortical cytoskeleton organization (GO:0030865)2.70872463
156endothelial cell proliferation (GO:0001935)2.70831124
157aromatic amino acid family metabolic process (GO:0009072)2.70591963
158positive regulation of actin filament depolymerization (GO:0030836)2.69716754
159glomerular epithelial cell development (GO:0072310)2.69627403
160positive regulation of hormone metabolic process (GO:0032352)2.69426590
161regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69421606
162negative regulation of lipase activity (GO:0060192)2.68782054
163substrate adhesion-dependent cell spreading (GO:0034446)2.68152124
164extracellular matrix assembly (GO:0085029)2.67074487
165cellular response to vitamin D (GO:0071305)2.66920901
166endothelial cell differentiation (GO:0045446)2.66825526
167ethanol oxidation (GO:0006069)2.66786274
168endocardial cushion morphogenesis (GO:0003203)2.66006916
169adherens junction assembly (GO:0034333)2.64690345
170endocardial cushion development (GO:0003197)2.64085600
171stress fiber assembly (GO:0043149)2.63997732
172lipoprotein metabolic process (GO:0042157)2.63591864
173mitotic nuclear envelope reassembly (GO:0007084)2.63339747
174nuclear envelope reassembly (GO:0031468)2.63339747
175positive regulation of vasculogenesis (GO:2001214)2.63073829
176positive regulation of Rho protein signal transduction (GO:0035025)2.62319974
177negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.60344624
178membrane raft organization (GO:0031579)2.60284435
179mesoderm formation (GO:0001707)2.59921847
180regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59632568
181epithelial cell-cell adhesion (GO:0090136)2.59324179
182establishment of viral latency (GO:0019043)2.58999778
183apoptotic cell clearance (GO:0043277)2.58753037
184* collagen metabolic process (GO:0032963)2.58625074
185mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.57793214
186hippo signaling (GO:0035329)2.57182416
187regulation of anoikis (GO:2000209)2.56051750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.36835780
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.20210762
3LXR_22158963_ChIP-Seq_LIVER_Mouse4.50557501
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.39921314
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.97435446
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.80271727
7* CLOCK_20551151_ChIP-Seq_293T_Human3.37063843
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.30213316
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.28211492
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.01761553
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.79806056
12GATA1_22025678_ChIP-Seq_K562_Human2.68962439
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.60591505
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.55535281
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.55535281
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.55535281
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.49683253
18ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.26733460
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26459895
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.24580597
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.22364959
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.17277973
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.17277973
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15267522
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.13424355
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08534193
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96967123
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94249933
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.91885025
30UBF1/2_26484160_Chip-Seq_HMECs_Human1.91483435
31JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90520921
32AR_21909140_ChIP-Seq_LNCAP_Human1.90369168
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76207690
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70806421
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.68454005
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68287584
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67447987
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65191150
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62503469
40ATF3_27146783_Chip-Seq_COLON_Human1.58715565
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55086511
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54837407
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54581633
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.52759809
45* TP53_22127205_ChIP-Seq_IMR90_Human1.51546335
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.44962421
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.40730328
48SMC1_22415368_ChIP-Seq_MEFs_Mouse1.40594130
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.39198828
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38441959
51TP53_23651856_ChIP-Seq_MEFs_Mouse1.36335469
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.36258891
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.32952571
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32147912
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30955658
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.29442076
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29006776
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.27790421
59EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26665735
60SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25426403
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24834865
62MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24506050
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24184645
64NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23764451
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.23546687
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.23546687
67* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23350254
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.20146961
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19670989
70FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17070202
71* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16827427
72RACK7_27058665_Chip-Seq_MCF-7_Human1.16045398
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15421753
74TP53_18474530_ChIP-ChIP_U2OS_Human1.13946116
75* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13576027
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13517166
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13042993
78* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12034008
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12009367
80ZNF263_19887448_ChIP-Seq_K562_Human1.11783054
81* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10460443
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09959953
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09214911
84LXR_22292898_ChIP-Seq_THP-1_Human1.08681218
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08643578
86* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08139449
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07961099
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07530383
89SOX17_20123909_ChIP-Seq_XEN_Mouse1.06543055
90* SA1_22415368_ChIP-Seq_MEFs_Mouse1.06332349
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05807008
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04574332
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04472448
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03799762
95KDM2B_26808549_Chip-Seq_K562_Human1.01541673
96* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00942827
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99346973
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97061976
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97032339
100* CDX2_20551321_ChIP-Seq_CACO-2_Human0.96620933
101EOMES_21245162_ChIP-Seq_HESCs_Human0.95814810
102ESR1_20079471_ChIP-ChIP_T-47D_Human0.94679724
103EED_16625203_ChIP-ChIP_MESCs_Mouse0.94032748
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93964367
105NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93840410
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.92179583
107GATA4_25053715_ChIP-Seq_YYC3_Human0.91802163
108* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91565415
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91428233
110* TP53_20018659_ChIP-ChIP_R1E_Mouse0.90691023
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90569928
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89692727
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.89371690
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.88964202
115* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88751450
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88430867
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88426447
118* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88238910
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88220864
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87485616
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87386143
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86051690
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85808023
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85659713
125* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83237048
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82224340
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.82103496
128* CJUN_26792858_Chip-Seq_BT549_Human0.81731179
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81583769
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80235915
131ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79711610
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78016229
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77956707
134SOX2_20726797_ChIP-Seq_SW620_Human0.77239382
135GATA1_19941826_ChIP-Seq_K562_Human0.77186263
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77159058
137CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77140251
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77028277
139CREB1_26743006_Chip-Seq_LNCaP_Human0.75780332
140* BRD4_25478319_ChIP-Seq_HGPS_Human0.74288307
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74252699
142* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73981844
143CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73735324
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73610274
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73241381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.65384393
2MP0002139_abnormal_hepatobiliary_system4.30093019
3MP0005360_urolithiasis3.88804717
4MP0001879_abnormal_lymphatic_vessel3.64320021
5* MP0004272_abnormal_basement_membrane3.61011750
6MP0002877_abnormal_melanocyte_morpholog3.43286495
7MP0005085_abnormal_gallbladder_physiolo3.36625400
8MP0005365_abnormal_bile_salt3.31314076
9MP0008875_abnormal_xenobiotic_pharmacok2.95606144
10MP0005167_abnormal_blood-brain_barrier2.71364760
11MP0003950_abnormal_plasma_membrane2.69791328
12MP0003705_abnormal_hypodermis_morpholog2.68317071
13MP0003252_abnormal_bile_duct2.46660191
14MP0002138_abnormal_hepatobiliary_system2.32439154
15MP0003091_abnormal_cell_migration2.21592379
16MP0008438_abnormal_cutaneous_collagen2.19095486
17MP0004185_abnormal_adipocyte_glucose2.17898492
18MP0001299_abnormal_eye_distance/2.10549925
19MP0010329_abnormal_lipoprotein_level1.85191406
20MP0009840_abnormal_foam_cell1.77748833
21MP0003122_maternal_imprinting1.71501018
22MP0005275_abnormal_skin_tensile1.70018941
23MP0010352_gastrointestinal_tract_polyps1.68287398
24* MP0000751_myopathy1.61247884
25MP0000733_abnormal_muscle_development1.61079169
26MP0005197_abnormal_uvea_morphology1.52643563
27MP0000762_abnormal_tongue_morphology1.52192304
28MP0000767_abnormal_smooth_muscle1.49014455
29MP0005083_abnormal_biliary_tract1.44893266
30MP0000428_abnormal_craniofacial_morphol1.44730791
31MP0000013_abnormal_adipose_tissue1.39066207
32MP0004084_abnormal_cardiac_muscle1.38982414
33MP0003119_abnormal_digestive_system1.36124023
34MP0000537_abnormal_urethra_morphology1.35315834
35MP0001666_abnormal_nutrient_absorption1.32082943
36MP0003115_abnormal_respiratory_system1.31892047
37MP0001542_abnormal_bone_strength1.31418493
38MP0001243_abnormal_dermal_layer1.30863307
39MP0003806_abnormal_nucleotide_metabolis1.30783557
40MP0002249_abnormal_larynx_morphology1.30411861
41MP0004264_abnormal_extraembryonic_tissu1.30402689
42MP0006054_spinal_hemorrhage1.29299825
43MP0006138_congestive_heart_failure1.28963422
44MP0001958_emphysema1.28297140
45MP0005451_abnormal_body_composition1.26669299
46MP0005257_abnormal_intraocular_pressure1.25438847
47MP0009780_abnormal_chondrocyte_physiolo1.23981002
48MP0004858_abnormal_nervous_system1.23879167
49MP0004782_abnormal_surfactant_physiolog1.23275285
50* MP0000749_muscle_degeneration1.21399536
51MP0003828_pulmonary_edema1.20686427
52MP0009053_abnormal_anal_canal1.20545057
53MP0010030_abnormal_orbit_morphology1.19129031
54MP0004019_abnormal_vitamin_homeostasis1.18527284
55MP0002896_abnormal_bone_mineralization1.17749769
56MP0000534_abnormal_ureter_morphology1.17145941
57MP0003868_abnormal_feces_composition1.16752660
58MP0005332_abnormal_amino_acid1.16187285
59MP0002295_abnormal_pulmonary_circulatio1.14686999
60MP0003191_abnormal_cellular_cholesterol1.14151876
61MP0003279_aneurysm1.13457381
62MP0002127_abnormal_cardiovascular_syste1.13257766
63MP0005503_abnormal_tendon_morphology1.12423596
64MP0010234_abnormal_vibrissa_follicle1.10615005
65MP0001915_intracranial_hemorrhage1.10582205
66MP0000750_abnormal_muscle_regeneration1.05995915
67MP0000609_abnormal_liver_physiology1.02049303
68MP0003123_paternal_imprinting1.01300384
69MP0003385_abnormal_body_wall1.00309195
70MP0000003_abnormal_adipose_tissue1.00184839
71MP0002925_abnormal_cardiovascular_devel0.97778684
72MP0002128_abnormal_blood_circulation0.96893367
73MP0003935_abnormal_craniofacial_develop0.95685960
74MP0002177_abnormal_outer_ear0.95420658
75MP0005595_abnormal_vascular_smooth0.93850747
76MP0001849_ear_inflammation0.92904241
77MP0009384_cardiac_valve_regurgitation0.92535476
78MP0003567_abnormal_fetal_cardiomyocyte0.92334839
79MP0001614_abnormal_blood_vessel0.92003526
80MP0000432_abnormal_head_morphology0.90632058
81* MP0000759_abnormal_skeletal_muscle0.90570744
82MP0002282_abnormal_trachea_morphology0.90479159
83MP0001348_abnormal_lacrimal_gland0.89512395
84MP0005319_abnormal_enzyme/_coenzyme0.89080550
85MP0004036_abnormal_muscle_relaxation0.88985184
86MP0002118_abnormal_lipid_homeostasis0.88306939
87MP0005666_abnormal_adipose_tissue0.88273153
88MP0003329_amyloid_beta_deposits0.88193358
89MP0002697_abnormal_eye_size0.87866321
90MP0002932_abnormal_joint_morphology0.87856881
91MP0005508_abnormal_skeleton_morphology0.87383575
92MP0000858_altered_metastatic_potential0.87250893
93MP0004233_abnormal_muscle_weight0.87107782
94MP0003941_abnormal_skin_development0.85797222
95MP0005390_skeleton_phenotype0.85621999
96MP0002089_abnormal_postnatal_growth/wei0.85310382
97MP0000462_abnormal_digestive_system0.85146370
98MP0003755_abnormal_palate_morphology0.85093692
99MP0003942_abnormal_urinary_system0.84581379
100MP0005330_cardiomyopathy0.84384406
101MP0002933_joint_inflammation0.83775778
102MP0002086_abnormal_extraembryonic_tissu0.82092418
103MP0009697_abnormal_copulation0.81628528
104MP0003195_calcinosis0.80592901
105MP0003283_abnormal_digestive_organ0.80534812
106* MP0003566_abnormal_cell_adhesion0.80179338
107MP0005248_abnormal_Harderian_gland0.79800652
108MP0002085_abnormal_embryonic_tissue0.79750032
109MP0009250_abnormal_appendicular_skeleto0.79279106
110MP0005193_abnormal_anterior_eye0.79005310
111MP0000049_abnormal_middle_ear0.78650926
112MP0002113_abnormal_skeleton_development0.78286488
113MP0005023_abnormal_wound_healing0.77993004
114MP0005164_abnormal_response_to0.77228952
115MP0002084_abnormal_developmental_patter0.76725545
116MP0005623_abnormal_meninges_morphology0.75893241
117MP0000639_abnormal_adrenal_gland0.75504217
118MP0005380_embryogenesis_phenotype0.73005101
119MP0001672_abnormal_embryogenesis/_devel0.73005101
120MP0009643_abnormal_urine_homeostasis0.72915027
121MP0000598_abnormal_liver_morphology0.72728655
122* MP0004087_abnormal_muscle_fiber0.72378580
123MP0000249_abnormal_blood_vessel0.72067717
124MP0000266_abnormal_heart_morphology0.72034346
125MP0000678_abnormal_parathyroid_gland0.71762485
126MP0002114_abnormal_axial_skeleton0.71497975
127* MP0005165_increased_susceptibility_to0.71099778
128MP0005385_cardiovascular_system_phenoty0.70377066
129MP0001544_abnormal_cardiovascular_syste0.70377066
130MP0005647_abnormal_sex_gland0.70344740
131MP0003984_embryonic_growth_retardation0.69752734
132MP0001340_abnormal_eyelid_morphology0.69421373
133MP0005187_abnormal_penis_morphology0.69269545
134MP0000163_abnormal_cartilage_morphology0.69182597
135MP0001175_abnormal_lung_morphology0.68729900
136MP0002116_abnormal_craniofacial_bone0.68519879
137MP0002092_abnormal_eye_morphology0.66576005
138MP0004883_abnormal_blood_vessel0.66318695
139MP0001293_anophthalmia0.66249123
140MP0005076_abnormal_cell_differentiation0.65826284
141MP0000747_muscle_weakness0.65730772
142MP0000613_abnormal_salivary_gland0.65618914
143MP0000566_synostosis0.65494628
144MP0002060_abnormal_skin_morphology0.64321460
145MP0002088_abnormal_embryonic_growth/wei0.63785868
146MP0003448_altered_tumor_morphology0.62886998
147MP0005220_abnormal_exocrine_pancreas0.62048263
148MP0010630_abnormal_cardiac_muscle0.61842999
149MP0003937_abnormal_limbs/digits/tail_de0.61671703

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.91877078
2Intrahepatic cholestasis (HP:0001406)4.50808018
3Protrusio acetabuli (HP:0003179)4.44643846
4Polycythemia (HP:0001901)4.17299440
5Arterial tortuosity (HP:0005116)4.01411662
6Vascular tortuosity (HP:0004948)3.98286022
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.95929448
8Cerebral aneurysm (HP:0004944)3.94511411
9Cervical subluxation (HP:0003308)3.94506891
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.92930859
11Short nail (HP:0001799)3.89906210
12Spinal rigidity (HP:0003306)3.87785544
13Esophageal varix (HP:0002040)3.83752743
14Xanthomatosis (HP:0000991)3.77329278
15Complement deficiency (HP:0004431)3.58381922
16Hypobetalipoproteinemia (HP:0003563)3.54272806
17Vertebral compression fractures (HP:0002953)3.42019431
18Hematochezia (HP:0002573)3.35326761
19Fragile skin (HP:0001030)3.34565955
20Back pain (HP:0003418)3.27283166
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.21056722
22Osteolytic defects of the hand bones (HP:0009699)3.21056722
23Lymphangioma (HP:0100764)3.17708833
24Conjunctival telangiectasia (HP:0000524)3.09101019
25Wormian bones (HP:0002645)3.08881837
26Hemorrhage of the eye (HP:0011885)3.03937707
27Premature rupture of membranes (HP:0001788)3.02728582
28Abnormality of the intrinsic pathway (HP:0010989)3.00313443
29Long toe (HP:0010511)2.96553091
30Broad metatarsal (HP:0001783)2.95476236
31Prolonged partial thromboplastin time (HP:0003645)2.95277274
32Shawl scrotum (HP:0000049)2.93784562
33Spontaneous hematomas (HP:0007420)2.92795299
34Soft skin (HP:0000977)2.87628655
35Broad face (HP:0000283)2.87254572
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.84481322
37Type 1 muscle fiber predominance (HP:0003803)2.82733136
38Abnormality of the common coagulation pathway (HP:0010990)2.82206931
39Hyperlipoproteinemia (HP:0010980)2.80904676
40Difficulty climbing stairs (HP:0003551)2.77590103
41Abnormality of methionine metabolism (HP:0010901)2.73985455
42Asymmetry of the thorax (HP:0001555)2.70604789
43Mildly elevated creatine phosphokinase (HP:0008180)2.70353902
44Ankle contracture (HP:0006466)2.69234583
45Nonimmune hydrops fetalis (HP:0001790)2.68685354
46Distal lower limb amyotrophy (HP:0008944)2.67994014
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66324828
48Visceral angiomatosis (HP:0100761)2.64982357
49Neonatal short-limb short stature (HP:0008921)2.64035592
50Hypolipoproteinemia (HP:0010981)2.63374453
51Genu recurvatum (HP:0002816)2.62626160
52Reduced subcutaneous adipose tissue (HP:0003758)2.62207727
53Joint hemorrhage (HP:0005261)2.61473447
54Shallow orbits (HP:0000586)2.58286468
55Camptodactyly of toe (HP:0001836)2.56703868
56Hypoglycemic coma (HP:0001325)2.56027446
57Slender build (HP:0001533)2.52872244
58Abnormality of complement system (HP:0005339)2.51720047
59Hemangiomatosis (HP:0007461)2.50532944
60Aneurysm (HP:0002617)2.49786647
61Hepatocellular carcinoma (HP:0001402)2.46457401
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.45252041
63Peritonitis (HP:0002586)2.41419403
64Ulnar bowing (HP:0003031)2.41241635
65Dilatation of the ascending aorta (HP:0005111)2.38698875
66Distal upper limb amyotrophy (HP:0007149)2.38540816
67Upper limb amyotrophy (HP:0009129)2.38540816
68Hypoalphalipoproteinemia (HP:0003233)2.37375169
69Hyperammonemia (HP:0001987)2.35617815
70Skin nodule (HP:0200036)2.35403282
71Midline defect of the nose (HP:0004122)2.33982387
72Aortic dissection (HP:0002647)2.33204368
73Joint laxity (HP:0001388)2.33113965
74Mitral valve prolapse (HP:0001634)2.31772481
75Epidermoid cyst (HP:0200040)2.31701138
76Wrist flexion contracture (HP:0001239)2.31056652
77Elbow flexion contracture (HP:0002987)2.30628681
78Hypophosphatemic rickets (HP:0004912)2.30112595
79Achilles tendon contracture (HP:0001771)2.29398848
80Abnormality of the distal phalanges of the toes (HP:0010182)2.29135312
81Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.28736186
82Bladder diverticulum (HP:0000015)2.24641196
83Ketosis (HP:0001946)2.23151402
84Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21973206
85Mitral regurgitation (HP:0001653)2.21129930
86Spondylolisthesis (HP:0003302)2.20841498
87Generalized amyotrophy (HP:0003700)2.20319669
88Metaphyseal cupping (HP:0003021)2.18331116
89Lower limb amyotrophy (HP:0007210)2.16170443
90Potter facies (HP:0002009)2.15334720
91Facial shape deformation (HP:0011334)2.15334720
92Natal tooth (HP:0000695)2.14345536
93Hyperglycinemia (HP:0002154)2.12076861
94Distal lower limb muscle weakness (HP:0009053)2.12016395
95Abnormality of the acetabulum (HP:0003170)2.10612951
96Cerebral hemorrhage (HP:0001342)2.10345601
97Fat malabsorption (HP:0002630)2.09124599
98Hyperextensible skin (HP:0000974)2.09095605
99Stroke (HP:0001297)2.08643423
100Abnormality of the umbilical cord (HP:0010881)2.08175201
101Hemiplegia (HP:0002301)2.05383027
102Hyperglycinuria (HP:0003108)2.04568511
103Mitral stenosis (HP:0001718)2.03619907
104Biconcave vertebral bodies (HP:0004586)2.02916384
105Abnormal delivery (HP:0001787)2.00506943
106Single umbilical artery (HP:0001195)2.00001981
107Abnormality of the fetal cardiovascular system (HP:0010948)2.00001981
108Abnormal umbilical cord blood vessels (HP:0011403)2.00001981
109Blue sclerae (HP:0000592)1.99836529
110Hyperacusis (HP:0010780)1.98233985
111Venous insufficiency (HP:0005293)1.97103600
112Glucose intolerance (HP:0000833)1.97023648
113Entropion (HP:0000621)1.96830401
114Renal duplication (HP:0000075)1.95832058
115Hypercholesterolemia (HP:0003124)1.95410249
116Limb-girdle muscle atrophy (HP:0003797)1.95291097
117Abnormality of skeletal muscle fiber size (HP:0012084)1.95036462
118Delayed cranial suture closure (HP:0000270)1.94035701
119Limb-girdle muscle weakness (HP:0003325)1.93941669
120Bowel diverticulosis (HP:0005222)1.93396068
121Increased variability in muscle fiber diameter (HP:0003557)1.93216210
122Spinal cord compression (HP:0002176)1.92675084
123Protruding ear (HP:0000411)1.92309381
124Abnormal ossification of hand bones (HP:0005921)1.91425491
125Spastic diplegia (HP:0001264)1.91374382
126Abnormality of the Achilles tendon (HP:0005109)1.90604360
127Hand muscle atrophy (HP:0009130)1.89834705
128Short clavicles (HP:0000894)1.89614954
129Atrophic scars (HP:0001075)1.89201128
130Portal hypertension (HP:0001409)1.88906951
131Joint stiffness (HP:0001387)1.87539972
132Abnormality of glycine metabolism (HP:0010895)1.86207482
133Abnormality of serine family amino acid metabolism (HP:0010894)1.86207482
134Aortic aneurysm (HP:0004942)1.85924880
135Enlarged kidneys (HP:0000105)1.84423989
136Wide anterior fontanel (HP:0000260)1.84320187
137Abnormality of dentin (HP:0010299)1.83823744
138Syringomyelia (HP:0003396)1.83790837
139Spinal cord lesions (HP:0100561)1.83790837
140Rickets (HP:0002748)1.83467753
141Increased connective tissue (HP:0009025)1.82940667
142Insomnia (HP:0100785)1.82451973
143Coxa vara (HP:0002812)1.82324080
144Joint contractures involving the joints of the feet (HP:0100492)1.81921923
145Flexion contracture of toe (HP:0005830)1.81921923
146Cardiovascular calcification (HP:0011915)1.81495664
147Follicular hyperkeratosis (HP:0007502)1.81110209
148Disproportionate tall stature (HP:0001519)1.80883485
149Hypoventilation (HP:0002791)1.80449184
150Turricephaly (HP:0000262)1.80162135
151Microglossia (HP:0000171)1.79164688
152Abnormality of oral frenula (HP:0000190)1.78910958
153Abnormal cartilage morphology (HP:0002763)1.78681396
154Abnormality of the pulmonary veins (HP:0011718)1.77626089
155Renovascular hypertension (HP:0100817)1.77082658
156Ectopia lentis (HP:0001083)1.76413962
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.76051307
158Overgrowth (HP:0001548)1.76000626
159Skull defect (HP:0001362)1.75877818
160Ketoacidosis (HP:0001993)1.74609603
161Bowed forearm bones (HP:0003956)1.74469590
162Bowing of the arm (HP:0006488)1.74469590
163Tetraparesis (HP:0002273)1.74404117
164Absent frontal sinuses (HP:0002688)1.73062275
165Striae distensae (HP:0001065)1.72706287
166Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72594289
167Vascular calcification (HP:0004934)1.72201809
168Abnormality of carpal bone ossification (HP:0006257)1.71051315
169Coronal craniosynostosis (HP:0004440)1.70293410
170Mild short stature (HP:0003502)1.70087900
171Deviation of the thumb (HP:0009603)1.69785128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.13458328
2KDR4.24524465
3TGFBR23.48224560
4TESK13.14426275
5LATS22.98359355
6LIMK12.93538731
7LATS12.92079743
8ERN12.85185918
9TRIB32.66798743
10DDR22.42884699
11SIK12.34315255
12LMTK22.30661430
13BUB12.09437651
14RIPK12.09105977
15PKN22.08358263
16PDGFRA2.05645961
17TGFBR12.02109020
18EPHB22.01979344
19MET1.97616242
20TESK21.88530552
21NME21.86926432
22PTK61.81995562
23ARAF1.79867741
24IRAK31.78645470
25FGFR41.76950181
26PTK2B1.64730759
27PTK21.55103705
28STK38L1.50380427
29STK381.47998135
30MAP3K101.42810028
31BCKDK1.39341906
32FGFR21.34634433
33FER1.33367414
34VRK21.25550665
35PAK41.25246780
36CDK81.23468372
37MYLK1.18318796
38PAK61.18098729
39ROCK21.17620931
40STK101.12226450
41EPHA31.07916380
42ERBB41.04749302
43TAOK31.03089746
44PDGFRB1.02410914
45MAP2K30.96852644
46ABL20.95288674
47SCYL20.94948766
48BMX0.94187023
49SMG10.92491259
50CDK120.91751284
51INSRR0.90071443
52MAP3K30.89090212
53TYRO30.89080881
54FLT30.89080150
55TAOK20.88254996
56RET0.87675964
57LRRK20.87245383
58STK30.86627515
59GRK10.81975421
60PRKD30.78844149
61MAP3K20.75136157
62PIM20.72908149
63CDK60.72806095
64PRKD10.72797245
65KSR20.72752166
66EPHB10.72353957
67TTN0.71593776
68MAP2K20.71494061
69PAK20.69384201
70BRAF0.68906724
71PAK10.67596263
72DMPK0.66940520
73MTOR0.64581284
74PRKG20.64509086
75GSK3A0.63904885
76ROCK10.61007748
77MAPK150.60699526
78MAP3K120.60203898
79ERBB20.59107791
80PBK0.58564656
81MAP2K70.57545231
82FGFR10.56273037
83MOS0.55165373
84DAPK30.54031960
85PRPF4B0.53561049
86MAP2K40.53500783
87WNK10.53447630
88MAP3K10.51835589
89MST1R0.51691726
90FRK0.50877326
91AURKA0.49929898
92NTRK10.48599519
93TRPM70.48257614
94CDK180.46833251
95BRSK10.46706453
96NEK90.46599579
97MAP3K80.46369569
98CDK150.46153487
99PRKAA20.45972986
100DAPK10.45945175
101CDK11A0.45838974
102SRPK10.45385828
103EPHA20.44507153
104ICK0.44438316
105CDK140.43940799
106BCR0.43248674
107FGFR30.41021372
108MAP2K10.40807474
109TAF10.40574850
110IGF1R0.39604204
111MAP3K70.39039717
112CDK70.37783620
113EGFR0.37549951
114DAPK20.37014909
115MAPK110.36996753
116CSK0.36832873
117JAK20.36693085
118EEF2K0.36639195
119RPS6KA20.36373616
120AKT30.35818569
121CAMK1D0.35343256
122MAP3K60.35005457
123NEK20.34089180
124PRKD20.33355861
125NEK10.33346486
126AURKB0.33243242
127PAK30.33191302
128PRKCH0.32862022
129AKT20.32761055
130PLK30.31725880
131MELK0.31191814
132CAMK1G0.30107150
133KSR10.28124816
134SRC0.27118020
135ILK0.26972392
136GRK70.26242458
137CAMK2G0.26073087
138PASK0.25681525
139ADRBK10.25508480
140CDK40.25448496
141PRKAA10.24860270
142STK40.24274854
143PIK3CG0.23259558
144TTK0.22619853
145PLK20.21931197
146CLK10.21546705
147INSR0.21412201
148CSF1R0.21161364

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99625449
2Nitrogen metabolism_Homo sapiens_hsa009103.59871313
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25730373
4Arginine biosynthesis_Homo sapiens_hsa002203.13429344
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.95847187
6Complement and coagulation cascades_Homo sapiens_hsa046102.77491457
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.64878536
8Tryptophan metabolism_Homo sapiens_hsa003802.58377781
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.51465188
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.47589668
11Selenocompound metabolism_Homo sapiens_hsa004502.35360558
12Fatty acid degradation_Homo sapiens_hsa000712.34492038
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.11379728
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07952295
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01649400
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.01456783
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95443849
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92242133
19Dilated cardiomyopathy_Homo sapiens_hsa054141.86874457
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85081450
21PPAR signaling pathway_Homo sapiens_hsa033201.84609968
22ECM-receptor interaction_Homo sapiens_hsa045121.84130972
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.76908331
24Bile secretion_Homo sapiens_hsa049761.69801555
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.58344145
26Retinol metabolism_Homo sapiens_hsa008301.57977649
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57688120
28Butanoate metabolism_Homo sapiens_hsa006501.57058139
29Histidine metabolism_Homo sapiens_hsa003401.55319447
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.54474771
31Chemical carcinogenesis_Homo sapiens_hsa052041.51471403
32Fatty acid metabolism_Homo sapiens_hsa012121.50564346
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47088144
34Shigellosis_Homo sapiens_hsa051311.44049620
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43609191
36Chronic myeloid leukemia_Homo sapiens_hsa052201.43017634
37Lysine degradation_Homo sapiens_hsa003101.38692764
38Fat digestion and absorption_Homo sapiens_hsa049751.37094174
39Propanoate metabolism_Homo sapiens_hsa006401.36873842
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35075674
41Peroxisome_Homo sapiens_hsa041461.34560888
42Pancreatic cancer_Homo sapiens_hsa052121.31056829
43Folate biosynthesis_Homo sapiens_hsa007901.30957466
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.30795453
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29975822
46* Protein digestion and absorption_Homo sapiens_hsa049741.29003106
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28706554
48Caffeine metabolism_Homo sapiens_hsa002321.28691782
49N-Glycan biosynthesis_Homo sapiens_hsa005101.28207727
50Axon guidance_Homo sapiens_hsa043601.23784406
51Wnt signaling pathway_Homo sapiens_hsa043101.20575007
52beta-Alanine metabolism_Homo sapiens_hsa004101.20429040
53Staphylococcus aureus infection_Homo sapiens_hsa051501.15095328
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14716971
55Starch and sucrose metabolism_Homo sapiens_hsa005001.13155618
56Basal cell carcinoma_Homo sapiens_hsa052171.10092149
57Adherens junction_Homo sapiens_hsa045201.07199967
58Focal adhesion_Homo sapiens_hsa045101.06730363
59Phenylalanine metabolism_Homo sapiens_hsa003601.05486808
60Tyrosine metabolism_Homo sapiens_hsa003501.04910777
61Vibrio cholerae infection_Homo sapiens_hsa051101.02912450
62Endocytosis_Homo sapiens_hsa041441.02392999
63Cysteine and methionine metabolism_Homo sapiens_hsa002701.01944258
64Melanoma_Homo sapiens_hsa052181.00521114
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00069778
66Biosynthesis of amino acids_Homo sapiens_hsa012300.97492174
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97249074
68Salmonella infection_Homo sapiens_hsa051320.97151077
69One carbon pool by folate_Homo sapiens_hsa006700.97141050
70Arginine and proline metabolism_Homo sapiens_hsa003300.93226532
71Pyruvate metabolism_Homo sapiens_hsa006200.92802744
72Sulfur metabolism_Homo sapiens_hsa009200.90426220
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88064673
74Gap junction_Homo sapiens_hsa045400.88039586
75Pentose phosphate pathway_Homo sapiens_hsa000300.87426774
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86740546
77Amoebiasis_Homo sapiens_hsa051460.85136290
78Renal cell carcinoma_Homo sapiens_hsa052110.84313556
79Glioma_Homo sapiens_hsa052140.84225620
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82045458
81ABC transporters_Homo sapiens_hsa020100.81426473
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81262596
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80836564
84Insulin resistance_Homo sapiens_hsa049310.80443314
85p53 signaling pathway_Homo sapiens_hsa041150.80182327
86Other glycan degradation_Homo sapiens_hsa005110.78182655
87TGF-beta signaling pathway_Homo sapiens_hsa043500.77287292
88Carbon metabolism_Homo sapiens_hsa012000.77135882
89Hippo signaling pathway_Homo sapiens_hsa043900.76966974
90VEGF signaling pathway_Homo sapiens_hsa043700.76867454
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76726859
92Notch signaling pathway_Homo sapiens_hsa043300.74916249
93Colorectal cancer_Homo sapiens_hsa052100.73776209
94Vitamin digestion and absorption_Homo sapiens_hsa049770.73747604
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72696430
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.72325095
97Fatty acid elongation_Homo sapiens_hsa000620.72161454
98Proteasome_Homo sapiens_hsa030500.70113843
99Apoptosis_Homo sapiens_hsa042100.70002819
100Dorso-ventral axis formation_Homo sapiens_hsa043200.69986132
101Endometrial cancer_Homo sapiens_hsa052130.68990232
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67739723
103Small cell lung cancer_Homo sapiens_hsa052220.67613601
104Prion diseases_Homo sapiens_hsa050200.67478411
105Cell cycle_Homo sapiens_hsa041100.66749668
106Prostate cancer_Homo sapiens_hsa052150.66389948
107HTLV-I infection_Homo sapiens_hsa051660.65299748
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62597487
109Ras signaling pathway_Homo sapiens_hsa040140.59480045
110Ovarian steroidogenesis_Homo sapiens_hsa049130.58691524
111Estrogen signaling pathway_Homo sapiens_hsa049150.57574755
112Hedgehog signaling pathway_Homo sapiens_hsa043400.57364704
113HIF-1 signaling pathway_Homo sapiens_hsa040660.55945980
114Proteoglycans in cancer_Homo sapiens_hsa052050.55783688
115GnRH signaling pathway_Homo sapiens_hsa049120.55508751
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55358468
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.52315295
118ErbB signaling pathway_Homo sapiens_hsa040120.51356998
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51339514
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51117419
121Malaria_Homo sapiens_hsa051440.51000929
122Salivary secretion_Homo sapiens_hsa049700.50542031
123Non-small cell lung cancer_Homo sapiens_hsa052230.50513866
124Nucleotide excision repair_Homo sapiens_hsa034200.50342005
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.50298092
126Glycerolipid metabolism_Homo sapiens_hsa005610.50149758
127Bladder cancer_Homo sapiens_hsa052190.48913414
128Linoleic acid metabolism_Homo sapiens_hsa005910.48871246
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46798101
130Fructose and mannose metabolism_Homo sapiens_hsa000510.45540377
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45181149
132Pyrimidine metabolism_Homo sapiens_hsa002400.42869889
133Glutathione metabolism_Homo sapiens_hsa004800.41618040
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.39417183
135Viral carcinogenesis_Homo sapiens_hsa052030.39392377
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39335872
137Hepatitis B_Homo sapiens_hsa051610.38508050
138TNF signaling pathway_Homo sapiens_hsa046680.37535255
139Platelet activation_Homo sapiens_hsa046110.37060693
140Tight junction_Homo sapiens_hsa045300.37041872
141Sulfur relay system_Homo sapiens_hsa041220.34169421
142Lysosome_Homo sapiens_hsa041420.33792944
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.33467395
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32770738
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31871009
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.30849189
147Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30721280
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30597840
149Glucagon signaling pathway_Homo sapiens_hsa049220.30550598
150Insulin signaling pathway_Homo sapiens_hsa049100.30497554
151Galactose metabolism_Homo sapiens_hsa000520.30086257
152Rap1 signaling pathway_Homo sapiens_hsa040150.30044697
153MicroRNAs in cancer_Homo sapiens_hsa052060.29123667
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.28496387
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28048585
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27831494
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.26419820
158Thyroid cancer_Homo sapiens_hsa052160.26270028
159Thyroid hormone synthesis_Homo sapiens_hsa049180.25989682
160Melanogenesis_Homo sapiens_hsa049160.24589179
161Pathways in cancer_Homo sapiens_hsa052000.24369838
162Renin-angiotensin system_Homo sapiens_hsa046140.22744051
163Adipocytokine signaling pathway_Homo sapiens_hsa049200.22604631

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