COL14A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.05627230
2extracellular fibril organization (GO:0043206)4.77923388
3complement activation, alternative pathway (GO:0006957)4.50809784
4regulation of protein activation cascade (GO:2000257)4.42340647
5peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.39364010
6peptidyl-glutamic acid carboxylation (GO:0017187)4.34344097
7protein carboxylation (GO:0018214)4.34344097
8L-phenylalanine catabolic process (GO:0006559)4.32500421
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.32500421
10regulation of complement activation (GO:0030449)4.31416398
11positive regulation of fatty acid beta-oxidation (GO:0032000)4.17304401
12cell migration involved in heart development (GO:0060973)4.16991429
13* collagen fibril organization (GO:0030199)4.15425663
14metanephric mesenchyme development (GO:0072075)4.14066712
15regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.12232128
16fibril organization (GO:0097435)4.10601144
17L-phenylalanine metabolic process (GO:0006558)4.08355172
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.08355172
19regulation of fibrinolysis (GO:0051917)4.06569908
20homocysteine metabolic process (GO:0050667)4.05503133
21glomerular filtration (GO:0003094)3.98439125
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96574745
23negative regulation of fibrinolysis (GO:0051918)3.95998445
24alpha-linolenic acid metabolic process (GO:0036109)3.91719168
25positive regulation of fatty acid oxidation (GO:0046321)3.85261667
26aromatic amino acid family catabolic process (GO:0009074)3.77205450
27mesenchymal-epithelial cell signaling (GO:0060638)3.75466784
28glomerular basement membrane development (GO:0032836)3.70345083
29glyoxylate metabolic process (GO:0046487)3.68142350
30negative regulation of chondrocyte differentiation (GO:0032331)3.65818006
31bone trabecula formation (GO:0060346)3.63962031
32regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62476033
33renal filtration (GO:0097205)3.61247986
34kidney mesenchyme development (GO:0072074)3.60335152
35axon extension involved in axon guidance (GO:0048846)3.59511892
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.59511892
37vascular endothelial growth factor signaling pathway (GO:0038084)3.58721124
38regulation of plasminogen activation (GO:0010755)3.56904324
39* collagen metabolic process (GO:0032963)3.50901127
40bile acid biosynthetic process (GO:0006699)3.50850479
41urea metabolic process (GO:0019627)3.46910001
42urea cycle (GO:0000050)3.46910001
43paraxial mesoderm development (GO:0048339)3.45769278
44chondrocyte development (GO:0002063)3.44208593
45dermatan sulfate biosynthetic process (GO:0030208)3.43851849
46sequestering of extracellular ligand from receptor (GO:0035581)3.43663357
47kynurenine metabolic process (GO:0070189)3.37828422
48smooth muscle tissue development (GO:0048745)3.37086621
49* multicellular organismal macromolecule metabolic process (GO:0044259)3.36577401
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.36537319
51* collagen catabolic process (GO:0030574)3.34699405
52regulation of fatty acid beta-oxidation (GO:0031998)3.34241676
53sulfur amino acid catabolic process (GO:0000098)3.34008070
54negative regulation of protein activation cascade (GO:2000258)3.32822133
55dermatan sulfate metabolic process (GO:0030205)3.30468656
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.30342711
57opsonization (GO:0008228)3.30044538
58tryptophan catabolic process (GO:0006569)3.29651587
59indole-containing compound catabolic process (GO:0042436)3.29651587
60indolalkylamine catabolic process (GO:0046218)3.29651587
61high-density lipoprotein particle remodeling (GO:0034375)3.26037245
62* multicellular organismal metabolic process (GO:0044236)3.25570842
63lysine metabolic process (GO:0006553)3.25289550
64lysine catabolic process (GO:0006554)3.25289550
65fibrinolysis (GO:0042730)3.25152974
66positive regulation of Rho protein signal transduction (GO:0035025)3.24856306
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.23104964
68positive regulation of lipid catabolic process (GO:0050996)3.19409975
69cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.18474553
70tryptophan metabolic process (GO:0006568)3.17755136
71chondrocyte proliferation (GO:0035988)3.15592369
72* multicellular organismal catabolic process (GO:0044243)3.15076030
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.15001650
74regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.14482488
75regulation of triglyceride catabolic process (GO:0010896)3.14432781
76negative regulation of cartilage development (GO:0061037)3.14060322
77extracellular regulation of signal transduction (GO:1900115)3.11294708
78extracellular negative regulation of signal transduction (GO:1900116)3.11294708
79plasma lipoprotein particle clearance (GO:0034381)3.10270102
80nitrogen cycle metabolic process (GO:0071941)3.10040644
81negative regulation of catenin import into nucleus (GO:0035414)3.09976366
82cell proliferation involved in metanephros development (GO:0072203)3.08807014
83reverse cholesterol transport (GO:0043691)3.05648602
84acylglycerol homeostasis (GO:0055090)3.02095121
85triglyceride homeostasis (GO:0070328)3.02095121
86fatty acid transmembrane transport (GO:1902001)2.98575241
87* extracellular matrix organization (GO:0030198)2.97819417
88amino-acid betaine metabolic process (GO:0006577)2.97577149
89* extracellular structure organization (GO:0043062)2.96854987
90extracellular matrix assembly (GO:0085029)2.95880954
91bile acid metabolic process (GO:0008206)2.95137853
92heart morphogenesis (GO:0003007)2.94764959
93negative regulation of complement activation (GO:0045916)2.93955605
94positive regulation of glycogen biosynthetic process (GO:0045725)2.93899750
95phospholipid homeostasis (GO:0055091)2.92693873
96hippo signaling (GO:0035329)2.92607617
97* extracellular matrix disassembly (GO:0022617)2.92578961
98basement membrane organization (GO:0071711)2.92277432
99positive regulation of mesenchymal cell proliferation (GO:0002053)2.91790018
100phospholipid efflux (GO:0033700)2.91576349
101negative regulation of fatty acid transport (GO:2000192)2.91202839
102regulation of transforming growth factor beta2 production (GO:0032909)2.90260741
103cysteine metabolic process (GO:0006534)2.89386942
104regulation of fatty acid oxidation (GO:0046320)2.88466413
105tyrosine metabolic process (GO:0006570)2.88245503
106cardiac myofibril assembly (GO:0055003)2.87570393
107complement activation (GO:0006956)2.87549984
108lung vasculature development (GO:0060426)2.87509464
109wound healing, spreading of epidermal cells (GO:0035313)2.86803468
110skin morphogenesis (GO:0043589)2.86514626
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.85187060
112cellular glucuronidation (GO:0052695)2.84471249
113endodermal cell differentiation (GO:0035987)2.83511577
114endocrine hormone secretion (GO:0060986)2.82441036
115G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.82395426
116epoxygenase P450 pathway (GO:0019373)2.82059477
117organ induction (GO:0001759)2.81017194
118protein-lipid complex remodeling (GO:0034368)2.80868542
119macromolecular complex remodeling (GO:0034367)2.80868542
120plasma lipoprotein particle remodeling (GO:0034369)2.80868542
121complement activation, classical pathway (GO:0006958)2.79887065
122positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79772549
123positive regulation of fatty acid metabolic process (GO:0045923)2.77368522
124outer ear morphogenesis (GO:0042473)2.77219269
125negative regulation of embryonic development (GO:0045992)2.76875876
126regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.76007212
127carnitine shuttle (GO:0006853)2.74546425
128regulation of cholesterol homeostasis (GO:2000188)2.74171150
129positive regulation of glycogen metabolic process (GO:0070875)2.73733072
130serine family amino acid catabolic process (GO:0009071)2.71951745
131digestive tract development (GO:0048565)2.71804682
132cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71338038
133embryonic cranial skeleton morphogenesis (GO:0048701)2.70366387
134midgut development (GO:0007494)2.69217568
135regulation of cholesterol esterification (GO:0010872)2.69196896
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67982436
137keratan sulfate catabolic process (GO:0042340)2.66531247
138lipoprotein metabolic process (GO:0042157)2.66393492
139regulation of mesenchymal cell proliferation (GO:0010464)2.65322662
140middle ear morphogenesis (GO:0042474)2.63575819
141endothelial cell morphogenesis (GO:0001886)2.63023195
142fatty acid beta-oxidation (GO:0006635)2.62834426
143aromatic amino acid family metabolic process (GO:0009072)2.62776952
144glial cell migration (GO:0008347)2.62435992
145bile acid and bile salt transport (GO:0015721)2.62419580
146negative regulation of lipase activity (GO:0060192)2.62409855
147negative regulation of sterol transport (GO:0032372)2.61830382
148negative regulation of cholesterol transport (GO:0032375)2.61830382
149positive regulation of smoothened signaling pathway (GO:0045880)2.61681141
150cellular ketone body metabolic process (GO:0046950)2.61547064
151substrate adhesion-dependent cell spreading (GO:0034446)2.61206873
152alpha-amino acid catabolic process (GO:1901606)2.60814232
153protein localization to cell surface (GO:0034394)2.58981666
154regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.58692627
155vasculature development (GO:0001944)2.58457901
156regulation of establishment of planar polarity (GO:0090175)2.57854415
1572-oxoglutarate metabolic process (GO:0006103)2.57500068
158cellular response to amino acid stimulus (GO:0071230)2.57258767
159acetyl-CoA metabolic process (GO:0006084)2.56933867
160negative regulation of blood coagulation (GO:0030195)2.56758505
161negative regulation of hemostasis (GO:1900047)2.56758505
162protein activation cascade (GO:0072376)2.56676057
163artery morphogenesis (GO:0048844)2.55928791
164insulin-like growth factor receptor signaling pathway (GO:0048009)2.55613779
165cell differentiation involved in metanephros development (GO:0072202)2.54889328
166myelination in peripheral nervous system (GO:0022011)2.54461813
167peripheral nervous system axon ensheathment (GO:0032292)2.54461813
168regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53081473
169craniofacial suture morphogenesis (GO:0097094)2.53041843
170eye morphogenesis (GO:0048592)2.52387568
171regulation of cardioblast differentiation (GO:0051890)2.51881299
172negative regulation of BMP signaling pathway (GO:0030514)2.51875149
173peptide cross-linking (GO:0018149)2.50191103
174non-canonical Wnt signaling pathway (GO:0035567)2.48812860
175regulation of chondrocyte differentiation (GO:0032330)2.47967689
176negative regulation of smooth muscle cell migration (GO:0014912)2.47780156
177prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.47362024
178convergent extension (GO:0060026)2.47348522
179mesenchyme morphogenesis (GO:0072132)2.46937946
180mesenchymal cell differentiation involved in renal system development (GO:2001012)2.46674246
181mesenchymal cell differentiation involved in kidney development (GO:0072161)2.46674246
182muscle cell migration (GO:0014812)2.46010846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.31947802
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.56192689
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.48568270
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.93763905
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.85871227
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.76926279
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.07020116
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.99724271
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.79618935
10CLOCK_20551151_ChIP-Seq_293T_Human2.78040132
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.72653414
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69037367
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66103863
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.50772045
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.47318473
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98784648
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.80558880
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.79167345
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78228310
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74157338
21CJUN_26792858_Chip-Seq_BT549_Human1.73013006
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68934759
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.68059663
24* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.66788204
25* EZH2_27304074_Chip-Seq_ESCs_Mouse1.66371043
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.65054164
27* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60881735
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59470495
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58976336
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58587687
31* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57802697
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52617507
33* GBX2_23144817_ChIP-Seq_PC3_Human1.49207038
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.48299474
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44106154
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.43463229
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40277215
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39387255
39* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38567074
40* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38567074
41GATA1_22025678_ChIP-Seq_K562_Human1.36322872
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30913616
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.28515121
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27170488
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24354074
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24124980
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.23871416
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.23871416
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23337581
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23158198
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.22105129
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.20825860
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19813683
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19555398
55* AR_21572438_ChIP-Seq_LNCaP_Human1.19530426
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.19225277
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.19033888
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18376331
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12391997
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12391997
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12391997
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11633393
63* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11564901
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10594205
65BRD4_25478319_ChIP-Seq_HGPS_Human1.09518914
66* SA1_22415368_ChIP-Seq_MEFs_Mouse1.09169156
67EZH2_22144423_ChIP-Seq_EOC_Human1.08544197
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07210043
69* RING1B_27294783_Chip-Seq_NPCs_Mouse1.06340540
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06079927
71ZNF263_19887448_ChIP-Seq_K562_Human1.05747758
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.05466912
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05059406
74TP53_18474530_ChIP-ChIP_U2OS_Human1.04961477
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04349788
76* PIAS1_25552417_ChIP-Seq_VCAP_Human1.01992721
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.01918390
78BCAT_22108803_ChIP-Seq_LS180_Human1.01685721
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01194296
80SMAD4_21799915_ChIP-Seq_A2780_Human1.00594005
81* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00435447
82* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00251346
83* RING1B_27294783_Chip-Seq_ESCs_Mouse0.99675363
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99155602
85* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98699714
86SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97680641
87* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97505496
88ISL1_27105846_Chip-Seq_CPCs_Mouse0.97425413
89* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97401052
90* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96874088
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95434943
92TP53_16413492_ChIP-PET_HCT116_Human0.95385336
93DROSHA_22980978_ChIP-Seq_HELA_Human0.94573175
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94232397
95NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93761646
96SOX2_20726797_ChIP-Seq_SW620_Human0.93712353
97CBX2_27304074_Chip-Seq_ESCs_Mouse0.92383878
98AHR_22903824_ChIP-Seq_MCF-7_Human0.89903930
99* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89525678
100* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89525678
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88734427
102HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87981474
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87807826
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87631710
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85822030
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84881953
107* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84819022
108* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83437856
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82439087
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.81788273
111HNF4A_19822575_ChIP-Seq_HepG2_Human0.80881984
112TP63_23658742_ChIP-Seq_EP156T_Human0.80681443
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80150317
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80103898
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79468061
116* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78870162
117PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77176977
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.75628590
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.75399548
120TCF4_18268006_ChIP-ChIP_LS174T_Human0.75012643
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73863951
122JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73217370
123P300_27058665_Chip-Seq_ZR-75-30cells_Human0.73045334
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72736824
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72669674
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71698945
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.71590730
128SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71559921
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71460341
130* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70926922
131GATA4_25053715_ChIP-Seq_YYC3_Human0.70326834
132* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.69894457
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.69729997
134VDR_24787735_ChIP-Seq_THP-1_Human0.69626596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.07164047
2* MP0005275_abnormal_skin_tensile5.01532134
3* MP0005503_abnormal_tendon_morphology4.12609679
4MP0002139_abnormal_hepatobiliary_system3.73514945
5MP0003705_abnormal_hypodermis_morpholog3.67355752
6MP0005360_urolithiasis3.50904795
7MP0004272_abnormal_basement_membrane3.49044685
8MP0005085_abnormal_gallbladder_physiolo2.88150827
9MP0005365_abnormal_bile_salt2.86101207
10MP0001958_emphysema2.79939501
11MP0003252_abnormal_bile_duct2.74316576
12MP0010368_abnormal_lymphatic_system2.53927667
13MP0003279_aneurysm2.46669120
14MP0002060_abnormal_skin_morphology2.20549027
15MP0010030_abnormal_orbit_morphology2.04777648
16MP0000751_myopathy2.04307661
17MP0008875_abnormal_xenobiotic_pharmacok2.02641141
18MP0009384_cardiac_valve_regurgitation1.88193034
19MP0006054_spinal_hemorrhage1.83428540
20MP0010329_abnormal_lipoprotein_level1.81232101
21* MP0002108_abnormal_muscle_morphology1.72667517
22MP0003941_abnormal_skin_development1.58270624
23MP0002837_dystrophic_cardiac_calcinosis1.52096772
24MP0001243_abnormal_dermal_layer1.36533950
25MP0002295_abnormal_pulmonary_circulatio1.33972067
26MP0003566_abnormal_cell_adhesion1.32800607
27MP0005257_abnormal_intraocular_pressure1.32344368
28MP0003045_fibrosis1.32320826
29MP0001299_abnormal_eye_distance/1.31973872
30* MP0005508_abnormal_skeleton_morphology1.26124723
31MP0005083_abnormal_biliary_tract1.25927525
32MP0005332_abnormal_amino_acid1.25822983
33MP0002168_other_aberrant_phenotype1.24121226
34MP0001661_extended_life_span1.21530427
35MP0003806_abnormal_nucleotide_metabolis1.21395839
36MP0002254_reproductive_system_inflammat1.20319649
37MP0002138_abnormal_hepatobiliary_system1.17206793
38MP0000428_abnormal_craniofacial_morphol1.12792610
39MP0000049_abnormal_middle_ear1.11589647
40MP0003195_calcinosis1.09779026
41MP0008004_abnormal_stomach_pH1.09716452
42MP0003191_abnormal_cellular_cholesterol1.09064805
43MP0009840_abnormal_foam_cell1.08813771
44MP0000767_abnormal_smooth_muscle1.05839006
45MP0004858_abnormal_nervous_system1.04350848
46MP0000609_abnormal_liver_physiology1.03292287
47MP0003091_abnormal_cell_migration1.03244234
48MP0001666_abnormal_nutrient_absorption1.03062259
49MP0002896_abnormal_bone_mineralization1.02542361
50MP0005023_abnormal_wound_healing1.02193641
51MP0009053_abnormal_anal_canal1.00768914
52MP0005330_cardiomyopathy1.00063907
53MP0002118_abnormal_lipid_homeostasis0.99944986
54MP0001879_abnormal_lymphatic_vessel0.97004487
55MP0002933_joint_inflammation0.96673105
56MP0002282_abnormal_trachea_morphology0.95801428
57MP0009780_abnormal_chondrocyte_physiolo0.95715465
58MP0001177_atelectasis0.95173021
59MP0004130_abnormal_muscle_cell0.94214999
60MP0000762_abnormal_tongue_morphology0.93680795
61MP0010386_abnormal_urinary_bladder0.92206333
62MP0001849_ear_inflammation0.92195605
63MP0000750_abnormal_muscle_regeneration0.90283041
64MP0005319_abnormal_enzyme/_coenzyme0.88325876
65MP0000432_abnormal_head_morphology0.88287287
66MP0003385_abnormal_body_wall0.86871734
67MP0003115_abnormal_respiratory_system0.86226381
68MP0004019_abnormal_vitamin_homeostasis0.85931819
69MP0005670_abnormal_white_adipose0.85684239
70MP0000579_abnormal_nail_morphology0.85649541
71MP0002249_abnormal_larynx_morphology0.85517827
72MP0001542_abnormal_bone_strength0.84284468
73MP0004134_abnormal_chest_morphology0.83978925
74MP0002166_altered_tumor_susceptibility0.82642890
75MP0003935_abnormal_craniofacial_develop0.81872369
76MP0002116_abnormal_craniofacial_bone0.81297653
77MP0005409_darkened_coat_color0.81144446
78MP0010352_gastrointestinal_tract_polyps0.80755924
79MP0001614_abnormal_blood_vessel0.80591052
80MP0009250_abnormal_appendicular_skeleto0.79423750
81MP0002114_abnormal_axial_skeleton0.79191217
82MP0000013_abnormal_adipose_tissue0.79105580
83MP0005220_abnormal_exocrine_pancreas0.78851664
84MP0004087_abnormal_muscle_fiber0.77900882
85MP0000759_abnormal_skeletal_muscle0.77767131
86MP0005595_abnormal_vascular_smooth0.77562405
87MP0004084_abnormal_cardiac_muscle0.77359285
88MP0000534_abnormal_ureter_morphology0.77208855
89MP0002128_abnormal_blood_circulation0.76689260
90MP0002109_abnormal_limb_morphology0.76344717
91MP0002113_abnormal_skeleton_development0.75415926
92MP0005623_abnormal_meninges_morphology0.74987884
93MP0002233_abnormal_nose_morphology0.74108820
94MP0005171_absent_coat_pigmentation0.73275927
95MP0004883_abnormal_blood_vessel0.73246074
96MP0001175_abnormal_lung_morphology0.72474994
97MP0003300_gastrointestinal_ulcer0.71661558
98MP0003755_abnormal_palate_morphology0.70986755
99MP0008775_abnormal_heart_ventricle0.70932276
100MP0000163_abnormal_cartilage_morphology0.69790419
101MP0006138_congestive_heart_failure0.69652802
102MP0002115_abnormal_skeleton_extremities0.69039250
103MP0000749_muscle_degeneration0.67241017
104MP0000538_abnormal_urinary_bladder0.67214420
105MP0001544_abnormal_cardiovascular_syste0.66990468
106MP0005385_cardiovascular_system_phenoty0.66990468
107MP0005666_abnormal_adipose_tissue0.66488333
108MP0000003_abnormal_adipose_tissue0.66399058
109MP0003868_abnormal_feces_composition0.66340841
110* MP0005390_skeleton_phenotype0.65123337
111MP0003937_abnormal_limbs/digits/tail_de0.64247705
112MP0002006_tumorigenesis0.64002910
113MP0002133_abnormal_respiratory_system0.63975302
114MP0005388_respiratory_system_phenotype0.63975302
115MP0002925_abnormal_cardiovascular_devel0.63668327
116MP0005375_adipose_tissue_phenotype0.63337793
117MP0001270_distended_abdomen0.63317466
118MP0001756_abnormal_urination0.63286874
119MP0010630_abnormal_cardiac_muscle0.63140053
120MP0000733_abnormal_muscle_development0.63043396
121* MP0005369_muscle_phenotype0.60091530
122MP0005164_abnormal_response_to0.59882190
123MP0003724_increased_susceptibility_to0.58878961
124MP0004036_abnormal_muscle_relaxation0.58267087
125MP0002697_abnormal_eye_size0.58124121
126MP0002998_abnormal_bone_remodeling0.57884914
127MP0005620_abnormal_muscle_contractility0.57740130
128MP0009643_abnormal_urine_homeostasis0.57594247
129MP0003950_abnormal_plasma_membrane0.56904055
130MP0000462_abnormal_digestive_system0.56312334
131MP0002932_abnormal_joint_morphology0.56266153
132MP0005248_abnormal_Harderian_gland0.56052266
133MP0003011_delayed_dark_adaptation0.55747214
134MP0003942_abnormal_urinary_system0.55108922
135MP0000266_abnormal_heart_morphology0.54480874
136MP0010771_integument_phenotype0.51872885
137MP0003938_abnormal_ear_development0.51011203
138MP0000566_synostosis0.49155155
139MP0003795_abnormal_bone_structure0.47932491
140MP0002127_abnormal_cardiovascular_syste0.47542080

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.42222169
2Premature rupture of membranes (HP:0001788)5.34061328
3Broad metatarsal (HP:0001783)5.10095303
4Ankle contracture (HP:0006466)5.03113512
5Aortic dissection (HP:0002647)4.70715217
6Type 1 muscle fiber predominance (HP:0003803)4.43363356
7Deep venous thrombosis (HP:0002625)4.28353248
8Atrophic scars (HP:0001075)4.27814550
9Increased connective tissue (HP:0009025)4.20338196
10Follicular hyperkeratosis (HP:0007502)4.06863011
11Soft skin (HP:0000977)4.05993792
12Cerebral aneurysm (HP:0004944)3.88119057
13Fragile skin (HP:0001030)3.80451776
14Mitral valve prolapse (HP:0001634)3.80161230
15Complement deficiency (HP:0004431)3.68757852
16Bladder diverticulum (HP:0000015)3.63188460
17Aortic aneurysm (HP:0004942)3.61415062
18Shallow orbits (HP:0000586)3.55416065
19Peritonitis (HP:0002586)3.45485926
20Slender build (HP:0001533)3.43927186
21Striae distensae (HP:0001065)3.37277982
22Dilatation of the ascending aorta (HP:0005111)3.29676995
23Mitral stenosis (HP:0001718)3.23856253
24Vascular tortuosity (HP:0004948)3.20955332
25Xanthomatosis (HP:0000991)3.18956235
26Intrahepatic cholestasis (HP:0001406)3.12716760
27Spinal rigidity (HP:0003306)3.04578546
28Calcaneovalgus deformity (HP:0001848)2.97929524
29Arterial tortuosity (HP:0005116)2.87263139
30Alopecia of scalp (HP:0002293)2.84308089
31Increased variability in muscle fiber diameter (HP:0003557)2.81280233
32Abnormality of dentin (HP:0010299)2.80902952
33Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76720029
34Prolonged partial thromboplastin time (HP:0003645)2.76027843
35Abnormality of complement system (HP:0005339)2.75502594
36Deformed tarsal bones (HP:0008119)2.72461367
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.69664943
38Blue sclerae (HP:0000592)2.68878056
39Muscle fiber splitting (HP:0003555)2.64810186
40Wrist flexion contracture (HP:0001239)2.64610955
41Mildly elevated creatine phosphokinase (HP:0008180)2.62679575
42Hyperextensible skin (HP:0000974)2.62186896
43Ectopia lentis (HP:0001083)2.62109188
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.57062646
45Osteolytic defects of the hand bones (HP:0009699)2.57062646
46Hypoalphalipoproteinemia (HP:0003233)2.55030816
47Hyperlipoproteinemia (HP:0010980)2.51567014
48Abnormality of the common coagulation pathway (HP:0010990)2.51087950
49Aneurysm (HP:0002617)2.46676289
50Overgrowth (HP:0001548)2.43498691
51Cardiovascular calcification (HP:0011915)2.38924312
52Abnormality of skeletal muscle fiber size (HP:0012084)2.38015700
53Wormian bones (HP:0002645)2.36550335
54Venous insufficiency (HP:0005293)2.36361827
55Hypobetalipoproteinemia (HP:0003563)2.35569625
56Renovascular hypertension (HP:0100817)2.34398476
57Abnormal delivery (HP:0001787)2.30906342
58Hypolipoproteinemia (HP:0010981)2.29862825
59Genu recurvatum (HP:0002816)2.28236092
60Absent frontal sinuses (HP:0002688)2.23531768
61Abnormality of the calcaneus (HP:0008364)2.23505053
62Round ear (HP:0100830)2.23282303
63Limited hip movement (HP:0008800)2.23125234
64Biconcave vertebral bodies (HP:0004586)2.22584082
65Right ventricular cardiomyopathy (HP:0011663)2.20553634
66Persistence of primary teeth (HP:0006335)2.20425149
67Thin bony cortex (HP:0002753)2.19861272
68Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19746364
69Skin nodule (HP:0200036)2.19150553
70Pulmonary artery stenosis (HP:0004415)2.18452209
71Wide anterior fontanel (HP:0000260)2.17055227
72Increased corneal curvature (HP:0100692)2.15054403
73Keratoconus (HP:0000563)2.15054403
74Venous abnormality (HP:0002624)2.14937969
75Myocardial infarction (HP:0001658)2.14189470
76Mild short stature (HP:0003502)2.13649469
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13214914
78Joint hemorrhage (HP:0005261)2.13033131
79Cutaneous finger syndactyly (HP:0010554)2.11800514
80Hypoglycemic coma (HP:0001325)2.10264488
81Breech presentation (HP:0001623)2.09986901
82Osteoarthritis (HP:0002758)2.09763473
83Camptodactyly of toe (HP:0001836)2.08991558
84Disproportionate tall stature (HP:0001519)2.08613289
85Infantile muscular hypotonia (HP:0008947)2.06840440
86Joint laxity (HP:0001388)2.06836648
87Abnormality of the intrinsic pathway (HP:0010989)2.06801112
88Epidermoid cyst (HP:0200040)2.06575503
89Hypoplasia of the iris (HP:0007676)2.03278431
90Inguinal hernia (HP:0000023)2.02802333
91Abnormality of the ischium (HP:0003174)2.02103233
92Systemic lupus erythematosus (HP:0002725)2.01906149
93Lymphangioma (HP:0100764)2.01527433
94Mitral regurgitation (HP:0001653)2.00806293
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00476975
96Short 4th metacarpal (HP:0010044)2.00476975
97Abnormality of the 4th metacarpal (HP:0010012)2.00198731
98Cutaneous syndactyly (HP:0012725)1.98758826
99Ulnar claw (HP:0001178)1.98606568
100Flat cornea (HP:0007720)1.98086205
101Hyperammonemia (HP:0001987)1.97805224
102Narrow nasal bridge (HP:0000446)1.96506045
103Bowel diverticulosis (HP:0005222)1.96353271
104Distal arthrogryposis (HP:0005684)1.94542697
105Aortic valve stenosis (HP:0001650)1.94448077
106Ketosis (HP:0001946)1.91158170
107Neoplasm of the heart (HP:0100544)1.90467909
108Neonatal short-limb short stature (HP:0008921)1.89471817
109Coronal craniosynostosis (HP:0004440)1.89436958
110Hepatocellular carcinoma (HP:0001402)1.88918453
111Hip contracture (HP:0003273)1.88268648
112Esophageal varix (HP:0002040)1.86934665
113Vertebral compression fractures (HP:0002953)1.86895628
114Generalized amyotrophy (HP:0003700)1.86638306
115Gastrointestinal infarctions (HP:0005244)1.86386255
116Abnormality of the acetabulum (HP:0003170)1.85933255
117Aortic regurgitation (HP:0001659)1.85864670
118Deviation of the hallux (HP:0010051)1.84426581
119Broad long bones (HP:0005622)1.83717486
120Broad ribs (HP:0000885)1.83020049
121Ulnar bowing (HP:0003031)1.82391183
122Spondylolisthesis (HP:0003302)1.80957077
123Gingival overgrowth (HP:0000212)1.79773146
124Nonimmune hydrops fetalis (HP:0001790)1.79403353
125Turricephaly (HP:0000262)1.79239821
126Abnormality of skull ossification (HP:0002703)1.78590021
127Cervical subluxation (HP:0003308)1.77818646
128Hallux valgus (HP:0001822)1.76995566
129Vitreoretinal degeneration (HP:0000655)1.75128443
130Lipoatrophy (HP:0100578)1.74700912
131Decreased skull ossification (HP:0004331)1.74677927
132Spinal cord lesions (HP:0100561)1.74658584
133Syringomyelia (HP:0003396)1.74658584
134Midline defect of the nose (HP:0004122)1.73451456
135Trismus (HP:0000211)1.73427197
136Elbow flexion contracture (HP:0002987)1.73149324
137Hypoplasia of the maxilla (HP:0000327)1.71555230
138Glomerulonephritis (HP:0000099)1.68978366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.24441739
2LATS13.23222081
3ERN13.18245236
4TRIB33.15505763
5TTN2.97027845
6TGFBR22.79289936
7FGFR42.64153963
8EPHA32.57258385
9EEF2K2.50804210
10PDGFRA2.50361100
11DDR22.44090719
12BCKDK2.32410644
13TIE12.30244902
14PKN22.17354136
15FGFR22.04183075
16MYLK2.04166843
17EPHB12.00453520
18RIPK11.96103575
19CAMK1D1.83158731
20PTK61.72652236
21AKT31.65320107
22EPHB21.58366088
23MST1R1.56804828
24DMPK1.55507545
25INSRR1.55209927
26FRK1.49539218
27KIT1.41578868
28NEK91.39680653
29MAP3K61.39154443
30CAMK1G1.35487230
31FER1.34800704
32PIK3CA1.33873762
33OBSCN1.32478156
34MET1.29026278
35LATS21.21709362
36STK31.17224522
37JAK11.11882453
38PTK21.11828284
39FGFR31.10197837
40MAP3K71.06180957
41STK38L1.06140330
42PAK21.02614179
43PDGFRB1.01336822
44PTK2B0.98384898
45MAP3K100.98326003
46KDR0.98198264
47PIK3CG0.94398108
48LMTK20.93407155
49RET0.92505761
50CLK10.92247408
51ERBB20.91880089
52FGFR10.91584630
53MARK20.90457507
54CDK120.89878903
55ERBB40.89561580
56STK380.89539765
57GSK3A0.89132187
58MTOR0.87690441
59BMX0.87427219
60FLT30.85633237
61RPS6KA20.83327289
62PRKAA20.80999361
63MAPK150.80172371
64RPS6KC10.78080390
65RPS6KL10.78080390
66NUAK10.77254977
67TYK20.76847438
68MELK0.75332616
69ROCK10.74525763
70MAP3K30.73544775
71PRKD10.73031401
72CDK60.70617920
73SGK20.70437607
74PRKD20.70157440
75PRKCH0.70145030
76STK240.69941780
77PDK30.68571194
78PDK40.68571194
79JAK20.68381440
80TGFBR10.66590707
81MAPK110.66255770
82ICK0.64598731
83DYRK1B0.62867920
84RPS6KA60.62840059
85BRD40.60441163
86LRRK20.58683157
87IRAK10.58160786
88CSK0.56549780
89PAK30.55824667
90MAPK40.55440056
91PAK40.54027939
92ADRBK10.52364978
93MAP2K10.51840875
94ILK0.51156505
95MOS0.50483526
96SGK4940.49773113
97SGK2230.49773113
98TYRO30.49552788
99IGF1R0.47641611
100CHUK0.47228806
101PDK20.45801332
102MAPKAPK30.45753033
103DAPK20.44118107
104MAPK10.43553542
105CDC42BPA0.41806297
106PRKAA10.40504496
107ROCK20.40129977
108SGK30.39849115
109INSR0.39113255
110MAPK120.37978830
111NLK0.37022531
112PRPF4B0.35534268
113MAPK30.35397203
114CAMK40.35168177
115PRKACG0.34717242
116PHKG20.34194400
117PHKG10.34194400
118NTRK10.33985628
119SRC0.33972314
120TRPM70.33834699
121PRKG20.32292680
122MAP2K40.31477238
123MAP3K20.30319811
124CSF1R0.30169837
125ABL20.29903265
126PRKCE0.29274735
127MAPK70.29179846
128PRKG10.29072236
129MAP2K30.28843380
130STK390.27859980
131WNK10.26926231
132DAPK30.25602716

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.60962037
2Nitrogen metabolism_Homo sapiens_hsa009103.16740223
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.85666113
4Complement and coagulation cascades_Homo sapiens_hsa046102.85051497
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78098024
6Fatty acid degradation_Homo sapiens_hsa000712.55454467
7ECM-receptor interaction_Homo sapiens_hsa045122.52687007
8Arginine biosynthesis_Homo sapiens_hsa002202.46290009
9Tryptophan metabolism_Homo sapiens_hsa003802.31011823
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20788129
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18035547
12PPAR signaling pathway_Homo sapiens_hsa033202.11827740
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02795505
14Fatty acid metabolism_Homo sapiens_hsa012121.99143195
15Propanoate metabolism_Homo sapiens_hsa006401.98083462
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85849366
17Staphylococcus aureus infection_Homo sapiens_hsa051501.82008426
18* Protein digestion and absorption_Homo sapiens_hsa049741.78942021
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.76119532
20Butanoate metabolism_Homo sapiens_hsa006501.73539316
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64162343
22Caffeine metabolism_Homo sapiens_hsa002321.63554126
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62030398
24Histidine metabolism_Homo sapiens_hsa003401.51028368
25Peroxisome_Homo sapiens_hsa041461.50281879
26beta-Alanine metabolism_Homo sapiens_hsa004101.49591220
27Chemical carcinogenesis_Homo sapiens_hsa052041.48442648
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47731449
29Starch and sucrose metabolism_Homo sapiens_hsa005001.41418186
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41269999
31Renin secretion_Homo sapiens_hsa049241.40542019
32Bile secretion_Homo sapiens_hsa049761.37289104
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.33757837
34Phenylalanine metabolism_Homo sapiens_hsa003601.33263243
35Retinol metabolism_Homo sapiens_hsa008301.30212406
36Focal adhesion_Homo sapiens_hsa045101.29861540
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28787243
38Melanoma_Homo sapiens_hsa052181.26173644
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23410233
40Amoebiasis_Homo sapiens_hsa051461.22005129
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.20845711
42MicroRNAs in cancer_Homo sapiens_hsa052061.18756314
43Lysine degradation_Homo sapiens_hsa003101.18088782
44Notch signaling pathway_Homo sapiens_hsa043301.14544745
45Tyrosine metabolism_Homo sapiens_hsa003501.12654253
46Pyruvate metabolism_Homo sapiens_hsa006201.12130898
47Prostate cancer_Homo sapiens_hsa052151.12070348
48Axon guidance_Homo sapiens_hsa043601.11820630
49Tight junction_Homo sapiens_hsa045301.11530192
50Fat digestion and absorption_Homo sapiens_hsa049751.10594324
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.09343624
52Hippo signaling pathway_Homo sapiens_hsa043901.09038736
53ABC transporters_Homo sapiens_hsa020101.08212902
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06567778
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03709601
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03355925
57Fatty acid elongation_Homo sapiens_hsa000620.99914340
58Gap junction_Homo sapiens_hsa045400.98817653
59Chronic myeloid leukemia_Homo sapiens_hsa052200.98455992
60Melanogenesis_Homo sapiens_hsa049160.98004385
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97814772
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.96048587
63Wnt signaling pathway_Homo sapiens_hsa043100.94837757
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94345560
65Dorso-ventral axis formation_Homo sapiens_hsa043200.93136448
66Glioma_Homo sapiens_hsa052140.93067248
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92453306
68Selenocompound metabolism_Homo sapiens_hsa004500.91996836
69Dilated cardiomyopathy_Homo sapiens_hsa054140.91905214
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90215963
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89157780
72Carbon metabolism_Homo sapiens_hsa012000.87456532
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87212854
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.86178189
75Insulin resistance_Homo sapiens_hsa049310.85855000
76Sulfur metabolism_Homo sapiens_hsa009200.85794884
77Rap1 signaling pathway_Homo sapiens_hsa040150.84547191
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84516318
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82601497
80Fatty acid biosynthesis_Homo sapiens_hsa000610.81036160
81Choline metabolism in cancer_Homo sapiens_hsa052310.80710270
82Renal cell carcinoma_Homo sapiens_hsa052110.80519047
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.78248040
84GnRH signaling pathway_Homo sapiens_hsa049120.74229611
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73657795
86Arginine and proline metabolism_Homo sapiens_hsa003300.72632937
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70709042
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70355876
89Small cell lung cancer_Homo sapiens_hsa052220.70107511
90Prion diseases_Homo sapiens_hsa050200.68402983
91Estrogen signaling pathway_Homo sapiens_hsa049150.68239281
92Endometrial cancer_Homo sapiens_hsa052130.68111541
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.66162055
94Vitamin digestion and absorption_Homo sapiens_hsa049770.65111592
95Biosynthesis of amino acids_Homo sapiens_hsa012300.64328701
96Ras signaling pathway_Homo sapiens_hsa040140.64177157
97Pancreatic cancer_Homo sapiens_hsa052120.63831548
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63724507
99Circadian rhythm_Homo sapiens_hsa047100.62351805
100Calcium signaling pathway_Homo sapiens_hsa040200.62339366
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62259292
102Colorectal cancer_Homo sapiens_hsa052100.61299897
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59945759
104Oxytocin signaling pathway_Homo sapiens_hsa049210.59900670
105Glycerolipid metabolism_Homo sapiens_hsa005610.59798205
106Prolactin signaling pathway_Homo sapiens_hsa049170.59572651
107Thyroid cancer_Homo sapiens_hsa052160.59121625
108Proteoglycans in cancer_Homo sapiens_hsa052050.59063987
109Malaria_Homo sapiens_hsa051440.58720390
110mTOR signaling pathway_Homo sapiens_hsa041500.58578420
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57257053
112Adherens junction_Homo sapiens_hsa045200.57138569
113Gastric acid secretion_Homo sapiens_hsa049710.56216414
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55970887
115Basal cell carcinoma_Homo sapiens_hsa052170.55786386
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54990432
117FoxO signaling pathway_Homo sapiens_hsa040680.53715425
118Viral myocarditis_Homo sapiens_hsa054160.51835970
119cAMP signaling pathway_Homo sapiens_hsa040240.50958926
120MAPK signaling pathway_Homo sapiens_hsa040100.49237277
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.47394307
122Salivary secretion_Homo sapiens_hsa049700.45946065
123Pancreatic secretion_Homo sapiens_hsa049720.45916909
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45779030
125Hedgehog signaling pathway_Homo sapiens_hsa043400.44679971
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44662834
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.44400527
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43993296
129Pertussis_Homo sapiens_hsa051330.43881623
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43477579
131HTLV-I infection_Homo sapiens_hsa051660.42155947
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40674722
133AMPK signaling pathway_Homo sapiens_hsa041520.40534112
134Inositol phosphate metabolism_Homo sapiens_hsa005620.40367976
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.40005198
136Toxoplasmosis_Homo sapiens_hsa051450.39881768
137TGF-beta signaling pathway_Homo sapiens_hsa043500.39641476
138Other glycan degradation_Homo sapiens_hsa005110.39575493
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39307079
140ErbB signaling pathway_Homo sapiens_hsa040120.37557663
141Steroid biosynthesis_Homo sapiens_hsa001000.37101681
142Glucagon signaling pathway_Homo sapiens_hsa049220.36008750
143Glutathione metabolism_Homo sapiens_hsa004800.34707189
144Folate biosynthesis_Homo sapiens_hsa007900.32796739
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.30384724
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28186861
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27165310
148Insulin signaling pathway_Homo sapiens_hsa049100.26669120
149Renin-angiotensin system_Homo sapiens_hsa046140.26665589
150Bladder cancer_Homo sapiens_hsa052190.25347282
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21800836
152Platelet activation_Homo sapiens_hsa046110.21228659
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.20964836
154Galactose metabolism_Homo sapiens_hsa000520.20750650
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18776063
156Ovarian steroidogenesis_Homo sapiens_hsa049130.17725530
157Thyroid hormone synthesis_Homo sapiens_hsa049180.17006849
158Pathways in cancer_Homo sapiens_hsa052000.15938323

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