COL15A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)5.08200075
2glomerular filtration (GO:0003094)4.74374369
3low-density lipoprotein particle clearance (GO:0034383)4.68533162
4retina vasculature morphogenesis in camera-type eye (GO:0061299)4.49449853
5cell migration involved in heart development (GO:0060973)4.30346129
6renal filtration (GO:0097205)4.30148630
7keratan sulfate catabolic process (GO:0042340)4.11891374
8regulation of sequestering of triglyceride (GO:0010889)4.10552539
9ovulation from ovarian follicle (GO:0001542)4.09887039
10vascular endothelial growth factor signaling pathway (GO:0038084)4.06497199
11regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.94865342
12basement membrane organization (GO:0071711)3.91037839
13fatty acid transmembrane transport (GO:1902001)3.88156132
14cardiac myofibril assembly (GO:0055003)3.87671974
15endothelium development (GO:0003158)3.87424464
16carnitine shuttle (GO:0006853)3.81496547
17actin-mediated cell contraction (GO:0070252)3.76557545
18plasma membrane repair (GO:0001778)3.71406608
19white fat cell differentiation (GO:0050872)3.63831454
20collagen fibril organization (GO:0030199)3.63312510
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.56722114
22positive regulation of fatty acid oxidation (GO:0046321)3.51035759
23heart trabecula formation (GO:0060347)3.47384411
24skin morphogenesis (GO:0043589)3.43620062
25brown fat cell differentiation (GO:0050873)3.42875878
26cellular response to epinephrine stimulus (GO:0071872)3.32458799
27triglyceride catabolic process (GO:0019433)3.32393653
28sarcomere organization (GO:0045214)3.32145926
29metanephric mesenchyme development (GO:0072075)3.28534147
30endocrine hormone secretion (GO:0060986)3.27380893
31myofibril assembly (GO:0030239)3.24943584
32cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.22389049
33extracellular matrix assembly (GO:0085029)3.21656168
34glomerular basement membrane development (GO:0032836)3.19465928
35growth hormone receptor signaling pathway (GO:0060396)3.17378847
36* collagen metabolic process (GO:0032963)3.11794325
37regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10441730
38endothelial cell morphogenesis (GO:0001886)3.09923726
39peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.08293676
40* multicellular organismal macromolecule metabolic process (GO:0044259)3.08116345
41regulation of fatty acid oxidation (GO:0046320)3.06505334
42blood vessel maturation (GO:0001955)3.05618028
43regulation of cholesterol storage (GO:0010885)3.05603408
44extracellular fibril organization (GO:0043206)3.04725633
45trabecula formation (GO:0060343)3.04690217
46actin filament-based movement (GO:0030048)3.04231402
47negative regulation of fatty acid transport (GO:2000192)3.01946873
48lipid particle organization (GO:0034389)3.01631713
49* collagen catabolic process (GO:0030574)3.01058239
50valine metabolic process (GO:0006573)3.00666660
51venous blood vessel morphogenesis (GO:0048845)3.00317808
52biotin metabolic process (GO:0006768)2.99083072
53positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.99008991
54acylglycerol catabolic process (GO:0046464)2.98410036
55neutral lipid catabolic process (GO:0046461)2.98410036
56* multicellular organismal metabolic process (GO:0044236)2.97878534
57virion attachment to host cell (GO:0019062)2.96115936
58adhesion of symbiont to host cell (GO:0044650)2.96115936
59regulation of p38MAPK cascade (GO:1900744)2.95979897
60lymph vessel development (GO:0001945)2.95260710
61kidney mesenchyme development (GO:0072074)2.95135417
62positive regulation of glycogen biosynthetic process (GO:0045725)2.94464769
63adhesion of symbiont to host (GO:0044406)2.93834345
64negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.92628847
65insulin-like growth factor receptor signaling pathway (GO:0048009)2.90741415
66branching involved in salivary gland morphogenesis (GO:0060445)2.89732967
67negative regulation of heart growth (GO:0061117)2.89107187
68negative regulation of cardiac muscle tissue growth (GO:0055022)2.89107187
69carnitine transmembrane transport (GO:1902603)2.87134864
70response to epinephrine (GO:0071871)2.85819607
71neuron projection extension involved in neuron projection guidance (GO:1902284)2.85003977
72axon extension involved in axon guidance (GO:0048846)2.85003977
73regulation of fatty acid beta-oxidation (GO:0031998)2.84158814
74* multicellular organismal catabolic process (GO:0044243)2.83890833
75positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.76876267
76vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.76844687
77cellular response to growth hormone stimulus (GO:0071378)2.74661159
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73614856
79actomyosin structure organization (GO:0031032)2.72232045
80barbed-end actin filament capping (GO:0051016)2.71951196
81positive regulation of vasculogenesis (GO:2001214)2.71906485
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.70832492
83regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.70649671
84heart morphogenesis (GO:0003007)2.69671532
85bone trabecula formation (GO:0060346)2.69584833
86cardiac muscle cell proliferation (GO:0060038)2.68921123
87hemidesmosome assembly (GO:0031581)2.68730490
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.67902404
89cell migration involved in sprouting angiogenesis (GO:0002042)2.67800802
90negative regulation of protein autophosphorylation (GO:0031953)2.67629933
91apoptotic cell clearance (GO:0043277)2.67622103
92skeletal muscle contraction (GO:0003009)2.67125174
93sequestering of extracellular ligand from receptor (GO:0035581)2.67106585
94protein localization to cell surface (GO:0034394)2.67081918
95* extracellular matrix disassembly (GO:0022617)2.66537519
96cGMP-mediated signaling (GO:0019934)2.66377064
97myelination in peripheral nervous system (GO:0022011)2.66273789
98peripheral nervous system axon ensheathment (GO:0032292)2.66273789
99growth hormone secretion (GO:0030252)2.65216320
100cell-substrate junction assembly (GO:0007044)2.64732070
101fibril organization (GO:0097435)2.64169273
102carnitine transport (GO:0015879)2.62523855
103amino-acid betaine transport (GO:0015838)2.62523855
104actin-myosin filament sliding (GO:0033275)2.61840458
105muscle filament sliding (GO:0030049)2.61840458
106type B pancreatic cell proliferation (GO:0044342)2.61502105
107negative regulation of gluconeogenesis (GO:0045721)2.60739938
108negative regulation of Rho protein signal transduction (GO:0035024)2.60262491
109positive regulation of macrophage cytokine production (GO:0060907)2.59386869
110fibroblast migration (GO:0010761)2.59380657
111fatty acid beta-oxidation (GO:0006635)2.59118230
112positive regulation of endothelial cell apoptotic process (GO:2000353)2.57847853
113regulation of extracellular matrix disassembly (GO:0010715)2.56587262
114endodermal cell differentiation (GO:0035987)2.54893625
115regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.53883462
116phagocytosis, recognition (GO:0006910)2.53844380
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.53021959
118negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.52889422
119smooth muscle tissue development (GO:0048745)2.52876857
120negative regulation of protein localization to cell surface (GO:2000009)2.52841200
121positive regulation of p38MAPK cascade (GO:1900745)2.52625224
122* extracellular matrix organization (GO:0030198)2.52172346
123sarcoplasmic reticulum calcium ion transport (GO:0070296)2.51841204
124negative regulation of cartilage development (GO:0061037)2.51306930
125negative regulation of smooth muscle cell migration (GO:0014912)2.51294736
126* extracellular structure organization (GO:0043062)2.51199587
127bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51136806
128regulation of integrin-mediated signaling pathway (GO:2001044)2.50840854
129positive regulation of glycogen metabolic process (GO:0070875)2.49434215
130positive regulation of receptor recycling (GO:0001921)2.49059085
131regulation of skeletal muscle contraction (GO:0014819)2.47513304
132positive regulation of cellular response to insulin stimulus (GO:1900078)2.47012409
133cellular response to vitamin (GO:0071295)2.45188200
134tricarboxylic acid cycle (GO:0006099)2.42504671
135stress fiber assembly (GO:0043149)2.41616702
136patterning of blood vessels (GO:0001569)2.41323136
137ovulation (GO:0030728)2.41256013
138mesenchymal-epithelial cell signaling (GO:0060638)2.40402974
139regulation of tight junction assembly (GO:2000810)2.40247704
140chondrocyte proliferation (GO:0035988)2.39985611
141cell proliferation involved in metanephros development (GO:0072203)2.38777523
142glucocorticoid biosynthetic process (GO:0006704)2.37500443
143extracellular negative regulation of signal transduction (GO:1900116)2.37321683
144extracellular regulation of signal transduction (GO:1900115)2.37321683
145regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.32728634
146tooth mineralization (GO:0034505)2.32362227
147striated muscle contraction (GO:0006941)2.31407166
148sprouting angiogenesis (GO:0002040)2.31204376
149positive regulation of protein kinase C signaling (GO:0090037)2.30844815
150muscle cell migration (GO:0014812)2.30684036
151lymphangiogenesis (GO:0001946)2.29352257
152muscle contraction (GO:0006936)2.28349362
153cardiac muscle contraction (GO:0060048)2.25684512
154regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24300369
155complement activation, classical pathway (GO:0006958)2.24006056
156transcytosis (GO:0045056)2.23719603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.41943519
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.14386363
3CLOCK_20551151_ChIP-Seq_293T_Human3.32265404
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.94716351
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.85061388
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.79786948
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.65054003
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64124363
9* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.57126875
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.54286379
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21372635
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.20510555
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.07562662
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.07562662
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.94887987
16GATA2_21666600_ChIP-Seq_HMVEC_Human1.92635039
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.92583689
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84554606
19ZNF263_19887448_ChIP-Seq_K562_Human1.83626176
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75482102
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74067843
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68010563
23* LXR_22158963_ChIP-Seq_LIVER_Mouse1.64996411
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.63588223
25* CJUN_26792858_Chip-Seq_BT549_Human1.62299793
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62130542
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.57821553
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55243031
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50861193
30* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.47108174
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46564132
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.45764727
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45690173
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44825859
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.43821505
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.42891594
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41586555
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40933416
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36722363
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33070397
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.30983898
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.29821452
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28105374
44* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27140016
45* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27140016
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26469143
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23660591
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.22599196
49KDM2B_26808549_Chip-Seq_K562_Human1.21008539
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19805243
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19533278
52* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18213147
53* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17935835
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17794800
55* DROSHA_22980978_ChIP-Seq_HELA_Human1.16924646
56AHR_22903824_ChIP-Seq_MCF-7_Human1.16594360
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16175673
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14867408
59BRD4_25478319_ChIP-Seq_HGPS_Human1.14352983
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13922757
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12136755
62SA1_22415368_ChIP-Seq_MEFs_Mouse1.10606501
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09648123
64SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07751547
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07100407
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05942476
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05942476
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05311736
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05243993
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.04713588
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.04679826
72KDM2B_26808549_Chip-Seq_DND41_Human1.04609618
73GATA1_22025678_ChIP-Seq_K562_Human1.03054987
74* EED_16625203_ChIP-ChIP_MESCs_Mouse1.02833040
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02341307
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02128532
77* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02063852
78* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01770774
79GATA1_19941826_ChIP-Seq_K562_Human1.01454230
80TP53_18474530_ChIP-ChIP_U2OS_Human1.01422653
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.01313840
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00392113
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00220909
84* RNF2_27304074_Chip-Seq_ESCs_Mouse0.99887541
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99883049
86NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99852311
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99049199
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97483607
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97424751
90* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96957406
91SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95559976
92RACK7_27058665_Chip-Seq_MCF-7_Human0.95289420
93* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94882167
94LXR_22292898_ChIP-Seq_THP-1_Human0.94133842
95SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93273786
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.93012579
97VDR_24787735_ChIP-Seq_THP-1_Human0.92930015
98* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92634139
99TCF4_18268006_ChIP-ChIP_LS174T_Human0.92277669
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91630589
101TP53_23651856_ChIP-Seq_MEFs_Mouse0.89598626
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89581197
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89576610
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88777862
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.88437111
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88284876
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88229995
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87569098
109EZH2_27294783_Chip-Seq_ESCs_Mouse0.87283945
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87225745
111* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86125703
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.85900400
113ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85684353
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.84934910
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84848943
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84121160
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.84083274
118TP53_16413492_ChIP-PET_HCT116_Human0.84017256
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83216875
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81651962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.28546714
2MP0005275_abnormal_skin_tensile4.35871164
3MP0004272_abnormal_basement_membrane4.30368017
4MP0002837_dystrophic_cardiac_calcinosis3.89781893
5MP0005670_abnormal_white_adipose3.40335385
6MP0005503_abnormal_tendon_morphology3.24762151
7MP0004084_abnormal_cardiac_muscle3.00840749
8MP0003705_abnormal_hypodermis_morpholog2.99610759
9MP0010368_abnormal_lymphatic_system2.97398721
10* MP0000751_myopathy2.89973416
11MP0004130_abnormal_muscle_cell2.69503164
12MP0005666_abnormal_adipose_tissue2.52281192
13MP0003279_aneurysm2.34113399
14MP0004215_abnormal_myocardial_fiber2.32581463
15MP0004185_abnormal_adipocyte_glucose2.17767652
16MP0001958_emphysema2.15251936
17MP0005375_adipose_tissue_phenotype2.13596418
18MP0004036_abnormal_muscle_relaxation2.11833195
19MP0000013_abnormal_adipose_tissue2.00259430
20MP0005330_cardiomyopathy1.99442039
21MP0003828_pulmonary_edema1.99116653
22MP0008775_abnormal_heart_ventricle1.96842561
23MP0001879_abnormal_lymphatic_vessel1.92949124
24MP0000003_abnormal_adipose_tissue1.83741242
25MP0006138_congestive_heart_failure1.80906362
26* MP0004087_abnormal_muscle_fiber1.72613812
27MP0003566_abnormal_cell_adhesion1.68362711
28MP0000749_muscle_degeneration1.61872136
29* MP0000750_abnormal_muscle_regeneration1.61289317
30MP0001542_abnormal_bone_strength1.58410983
31* MP0002108_abnormal_muscle_morphology1.57851542
32MP0002972_abnormal_cardiac_muscle1.56122717
33MP0005620_abnormal_muscle_contractility1.53135507
34MP0003724_increased_susceptibility_to1.53016317
35MP0010630_abnormal_cardiac_muscle1.50921003
36* MP0001544_abnormal_cardiovascular_syste1.50776938
37* MP0005385_cardiovascular_system_phenoty1.50776938
38MP0003646_muscle_fatigue1.45813644
39MP0001661_extended_life_span1.43330715
40MP0003045_fibrosis1.40746512
41MP0002060_abnormal_skin_morphology1.37219214
42MP0005623_abnormal_meninges_morphology1.31107805
43MP0008004_abnormal_stomach_pH1.29347000
44MP0002971_abnormal_brown_adipose1.26575122
45MP0002933_joint_inflammation1.26064506
46MP0000759_abnormal_skeletal_muscle1.25474620
47MP0002295_abnormal_pulmonary_circulatio1.20493316
48* MP0002106_abnormal_muscle_physiology1.18178165
49* MP0005369_muscle_phenotype1.17640934
50MP0000343_altered_response_to1.16803806
51MP0005167_abnormal_blood-brain_barrier1.13271942
52MP0004145_abnormal_muscle_electrophysio1.12430114
53MP0000767_abnormal_smooth_muscle1.11783606
54MP0005508_abnormal_skeleton_morphology1.11028847
55MP0009115_abnormal_fat_cell1.10162351
56MP0004484_altered_response_of1.09297666
57MP0000733_abnormal_muscle_development1.05138337
58MP0006054_spinal_hemorrhage1.02601373
59MP0009780_abnormal_chondrocyte_physiolo1.01444422
60MP0004858_abnormal_nervous_system0.98059643
61MP0003950_abnormal_plasma_membrane0.97750600
62MP0002128_abnormal_blood_circulation0.97251961
63MP0005171_absent_coat_pigmentation0.96921390
64MP0003191_abnormal_cellular_cholesterol0.96160154
65MP0002166_altered_tumor_susceptibility0.94376459
66MP0002168_other_aberrant_phenotype0.93693142
67MP0002127_abnormal_cardiovascular_syste0.93567056
68MP0000747_muscle_weakness0.93194913
69MP0002269_muscular_atrophy0.93170802
70MP0002896_abnormal_bone_mineralization0.92940448
71MP0005334_abnormal_fat_pad0.89804425
72MP0005595_abnormal_vascular_smooth0.89470247
73MP0004510_myositis0.88055880
74MP0000266_abnormal_heart_morphology0.87250221
75MP0003941_abnormal_skin_development0.86494136
76MP0010329_abnormal_lipoprotein_level0.85962597
77MP0004085_abnormal_heartbeat0.85320022
78MP0005409_darkened_coat_color0.82704208
79* MP0001614_abnormal_blood_vessel0.81184753
80MP0002925_abnormal_cardiovascular_devel0.79511463
81MP0003300_gastrointestinal_ulcer0.79332418
82MP0005388_respiratory_system_phenotype0.78551638
83MP0002133_abnormal_respiratory_system0.78551638
84MP0005187_abnormal_penis_morphology0.78318738
85MP0005257_abnormal_intraocular_pressure0.77465907
86MP0003091_abnormal_cell_migration0.76498471
87MP0003137_abnormal_impulse_conducting0.76052239
88MP0000462_abnormal_digestive_system0.75422698
89MP0002115_abnormal_skeleton_extremities0.72624383
90MP0002970_abnormal_white_adipose0.71785015
91MP0003385_abnormal_body_wall0.71693923
92MP0009250_abnormal_appendicular_skeleto0.70056105
93MP0002006_tumorigenesis0.69860233
94MP0000249_abnormal_blood_vessel0.69749140
95MP0010352_gastrointestinal_tract_polyps0.67846168
96MP0004134_abnormal_chest_morphology0.67495458
97MP0001243_abnormal_dermal_layer0.67021994
98MP0005165_increased_susceptibility_to0.65017789
99MP0001756_abnormal_urination0.64920494
100MP0001299_abnormal_eye_distance/0.64061488
101MP0000230_abnormal_systemic_arterial0.63432745
102MP0002998_abnormal_bone_remodeling0.63062326
103MP0000534_abnormal_ureter_morphology0.62944660
104MP0002118_abnormal_lipid_homeostasis0.62263709
105MP0005164_abnormal_response_to0.62129766
106MP0002332_abnormal_exercise_endurance0.61210370
107MP0003567_abnormal_fetal_cardiomyocyte0.59822161
108MP0005023_abnormal_wound_healing0.59758008
109MP0000163_abnormal_cartilage_morphology0.59751348
110MP0003959_abnormal_lean_body0.59207342
111MP0009384_cardiac_valve_regurgitation0.58019185
112MP0005076_abnormal_cell_differentiation0.58005905
113MP0002254_reproductive_system_inflammat0.57153964
114MP0005390_skeleton_phenotype0.56582106
115MP0004233_abnormal_muscle_weight0.56174292

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)5.34559423
2Protrusio acetabuli (HP:0003179)5.22571570
3Increased connective tissue (HP:0009025)5.21066536
4Ankle contracture (HP:0006466)4.68064486
5Muscle fiber splitting (HP:0003555)4.59044013
6Cerebral aneurysm (HP:0004944)4.52496837
7Premature rupture of membranes (HP:0001788)4.47085418
8Type 1 muscle fiber predominance (HP:0003803)4.46637731
9Distal arthrogryposis (HP:0005684)4.39265865
10Aortic dissection (HP:0002647)4.08324315
11Shallow orbits (HP:0000586)3.76349387
12Increased variability in muscle fiber diameter (HP:0003557)3.73400022
13Nemaline bodies (HP:0003798)3.72786725
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.61971689
15Sudden death (HP:0001699)3.61904719
16Muscle fiber inclusion bodies (HP:0100299)3.58624797
17Follicular hyperkeratosis (HP:0007502)3.57298964
18Hyporeflexia of lower limbs (HP:0002600)3.56834429
19Ulnar deviation of the wrist (HP:0003049)3.49149782
20Spinal rigidity (HP:0003306)3.48611467
21Lipoatrophy (HP:0100578)3.36477944
22Aortic aneurysm (HP:0004942)3.26639575
23Abnormality of skeletal muscle fiber size (HP:0012084)3.24504230
24Vascular tortuosity (HP:0004948)3.21586661
25Ventricular tachycardia (HP:0004756)3.21318445
26Difficulty running (HP:0009046)3.19936616
27Soft skin (HP:0000977)3.11329070
28Right ventricular cardiomyopathy (HP:0011663)3.11036970
29Mitral valve prolapse (HP:0001634)3.09342444
30Bladder diverticulum (HP:0000015)3.03039187
31Atrophic scars (HP:0001075)3.00765928
32Calcaneovalgus deformity (HP:0001848)3.00451933
33Mildly elevated creatine phosphokinase (HP:0008180)2.94343057
34Slender build (HP:0001533)2.93981377
35Fragile skin (HP:0001030)2.92555629
36Breech presentation (HP:0001623)2.83289515
37Abnormality of the 4th metacarpal (HP:0010012)2.76315057
38Aneurysm (HP:0002617)2.75719106
39Neonatal short-limb short stature (HP:0008921)2.74482888
40Arterial tortuosity (HP:0005116)2.74411857
41Deformed tarsal bones (HP:0008119)2.68375160
42Short 4th metacarpal (HP:0010044)2.68197803
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.68197803
44Striae distensae (HP:0001065)2.66490337
45Atrial fibrillation (HP:0005110)2.64557178
46Abnormality of dentin (HP:0010299)2.62428654
47Cervical subluxation (HP:0003308)2.61361019
48Acanthosis nigricans (HP:0000956)2.58178974
49Dilatation of the ascending aorta (HP:0005111)2.57461341
50Pulmonary artery stenosis (HP:0004415)2.57072595
51Rectal prolapse (HP:0002035)2.55220644
52Calf muscle hypertrophy (HP:0008981)2.49173546
53Vertebral compression fractures (HP:0002953)2.48426863
54Hypoplasia of the iris (HP:0007676)2.48287753
55Myotonia (HP:0002486)2.46562422
56Supraventricular arrhythmia (HP:0005115)2.44933247
57Peritonitis (HP:0002586)2.44392320
58Exercise-induced myalgia (HP:0003738)2.42433706
59Wrist flexion contracture (HP:0001239)2.42322767
60Neck muscle weakness (HP:0000467)2.41665279
61Abnormal delivery (HP:0001787)2.41533503
62Abnormality of the calf musculature (HP:0001430)2.41109409
63Primary atrial arrhythmia (HP:0001692)2.40619547
64Limited hip movement (HP:0008800)2.39545971
65Lymphangioma (HP:0100764)2.34782928
66Oligomenorrhea (HP:0000876)2.33035843
67Biconcave vertebral bodies (HP:0004586)2.32727493
68Hypoplastic ischia (HP:0003175)2.31942542
69Abnormality of the left ventricular outflow tract (HP:0011103)2.30173368
70Subaortic stenosis (HP:0001682)2.30173368
71Myoglobinuria (HP:0002913)2.29284092
72Overgrowth (HP:0001548)2.29194288
73Hyperextensible skin (HP:0000974)2.27526294
74Venous abnormality (HP:0002624)2.25539193
75Supraventricular tachycardia (HP:0004755)2.25134100
76Bone cyst (HP:0012062)2.22652152
77Venous insufficiency (HP:0005293)2.21296734
78Nonimmune hydrops fetalis (HP:0001790)2.20890425
79Aortic regurgitation (HP:0001659)2.20656299
80Absent phalangeal crease (HP:0006109)2.17617361
81Bowel diverticulosis (HP:0005222)2.16371585
82Abnormality of the ischium (HP:0003174)2.14748048
83Muscle hypertrophy of the lower extremities (HP:0008968)2.13694829
84Distal lower limb muscle weakness (HP:0009053)2.13297560
85Blue sclerae (HP:0000592)2.08414663
86Asymmetric septal hypertrophy (HP:0001670)2.08286806
87Prolonged QT interval (HP:0001657)2.08003644
88Round ear (HP:0100830)2.07840493
89Exercise-induced muscle cramps (HP:0003710)2.07033238
90Dilated cardiomyopathy (HP:0001644)2.05979367
91Hematochezia (HP:0002573)2.05943118
92Abnormality of complement system (HP:0005339)2.04378752
93Joint laxity (HP:0001388)2.04082088
94Bronchomalacia (HP:0002780)2.03165215
95Centrally nucleated skeletal muscle fibers (HP:0003687)2.00274929
96Complement deficiency (HP:0004431)1.97973974
97Difficulty climbing stairs (HP:0003551)1.97058658
98Metatarsus adductus (HP:0001840)1.96631286
99Hemorrhage of the eye (HP:0011885)1.96623363
100Ectopia lentis (HP:0001083)1.94172316
101Elbow flexion contracture (HP:0002987)1.94127406
102Hypoventilation (HP:0002791)1.93880975
103Mitral regurgitation (HP:0001653)1.93519257
104Scapular winging (HP:0003691)1.93471070
105Trismus (HP:0000211)1.91261388
106Abnormality of the calcaneus (HP:0008364)1.90686178
107Joint stiffness (HP:0001387)1.89743596
108Toxemia of pregnancy (HP:0100603)1.89254964
109Wide anterior fontanel (HP:0000260)1.88323500
110Generalized amyotrophy (HP:0003700)1.88079890
111EMG: myopathic abnormalities (HP:0003458)1.88011394
112Enlarged penis (HP:0000040)1.87712645
113Bundle branch block (HP:0011710)1.87459467
114Thin bony cortex (HP:0002753)1.87444464
115Hip contracture (HP:0003273)1.85359035
116Neoplasm of the heart (HP:0100544)1.84812265
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84477524
118Facial diplegia (HP:0001349)1.84071552
119Genu recurvatum (HP:0002816)1.83928935
120Insulin-resistant diabetes mellitus (HP:0000831)1.83482968
121Abnormality of the parietal bone (HP:0002696)1.82423063
122Mitral stenosis (HP:0001718)1.81962101
123Polycythemia (HP:0001901)1.81189005
124Systemic lupus erythematosus (HP:0002725)1.80707737
125Spondylolisthesis (HP:0003302)1.80627991
126Infantile muscular hypotonia (HP:0008947)1.77416154
127Protruding ear (HP:0000411)1.77406768
128Distal lower limb amyotrophy (HP:0008944)1.75438099
129Mild short stature (HP:0003502)1.75108300
130Knee flexion contracture (HP:0006380)1.75101675
131Aortic valve stenosis (HP:0001650)1.74035782
132Syncope (HP:0001279)1.73116622
133Wormian bones (HP:0002645)1.70623907
134Disproportionate tall stature (HP:0001519)1.70275176
135Limb-girdle muscle weakness (HP:0003325)1.69389171
136Osteolytic defects of the hand bones (HP:0009699)1.69008524
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.69008524
138Broad ribs (HP:0000885)1.68720307
139Midline defect of the nose (HP:0004122)1.66660725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.56283576
2TRIB34.10828558
3TTN3.31341741
4CAMK1D3.11760249
5TGFBR23.05907725
6RIPK13.05693625
7SIK12.98835822
8CAMK1G2.63335784
9MYLK2.32407354
10PDGFRA2.32317137
11LMTK22.26514036
12PIK3CG2.23996246
13AKT32.23665826
14DMPK2.19348252
15LATS12.18936339
16PKN22.13129622
17ERN11.92847322
18KDR1.89540780
19EPHB21.81599981
20FGFR21.80613992
21DDR21.74671349
22PDK41.74482313
23PDK31.74482313
24KIT1.61819279
25PIK3CA1.60346479
26EPHB11.59424712
27INSRR1.56420429
28BCKDK1.50503787
29PHKG11.43021870
30PHKG21.43021870
31PDK21.33876843
32PTK2B1.33788857
33FER1.28914950
34OBSCN1.25364726
35PTK61.20649681
36TGFBR11.19745419
37FGFR31.19357767
38NTRK11.18467744
39PRKD11.11958981
40FGFR41.11273977
41PRKAA21.08589043
42PDGFRB1.05285232
43MAP3K31.01316755
44PRKD31.00662317
45TESK10.98005459
46JAK10.92628725
47PRKCH0.92359676
48EPHA30.92235883
49ABL20.91367687
50LATS20.87193615
51PAK20.85246512
52MAPK40.85215972
53NLK0.83485385
54MUSK0.82898124
55MET0.82815088
56MAP3K70.81826198
57FGFR10.81310798
58MST1R0.80177929
59MTOR0.80133324
60RET0.80025665
61ILK0.77703462
62ICK0.77661760
63BMX0.76369759
64PTK20.74238987
65MAP2K30.72957352
66ADRBK10.71284098
67ROCK10.68346576
68MAPK120.66432571
69TRPM70.66408764
70NEK90.65243162
71FRK0.65077157
72STK30.64567048
73GSK3A0.64487435
74PRKAA10.63838423
75MAP3K130.63750747
76GRK50.63073769
77JAK20.58167945
78PAK30.58081492
79CAMK40.57773286
80MAP3K100.57256759
81MOS0.55912398
82HIPK20.53955651
83MARK20.53797914
84STK38L0.53773205
85CSK0.50148317
86PRKG20.49776208
87ZAP700.48877512
88LRRK20.48500343
89PAK40.48147700
90LIMK10.47619497
91CDC42BPA0.47478362
92CAMK2G0.47335596
93MAP2K10.46871819
94PRKD20.46288534
95TYK20.45997137
96IGF1R0.45541405
97PDPK10.44924801
98WNK40.44306005
99KSR20.43850598
100WNK10.43170762
101CDK60.41551895
102FLT30.40573286
103RPS6KC10.39532880
104RPS6KL10.39532880
105PRPF4B0.38188163
106MAPKAPK30.37491857
107PRKG10.36829591
108INSR0.36220219
109CDK90.36190570
110SRC0.35847667
111MAP3K10.35064849
112MAP3K60.33153260
113STK240.33051956
114CAMK10.32152625
115CAMK2D0.31797223
116MARK10.31435491
117GRK10.30774900
118PRKCE0.29942485
119PRKACG0.29786630
120ROCK20.29425874
121MAPK30.29274077
122SGK30.27966658
123JAK30.27380186
124STK380.25800689
125PDK10.25030228
126DAPK30.21584030
127MAPK70.21542310
128EEF2K0.21428047
129RPS6KA20.20910203

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.38667166
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.01742361
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.87203073
4Propanoate metabolism_Homo sapiens_hsa006402.61401000
5PPAR signaling pathway_Homo sapiens_hsa033202.51465726
6Dilated cardiomyopathy_Homo sapiens_hsa054142.42612603
7Fatty acid biosynthesis_Homo sapiens_hsa000612.37496053
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.27590700
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.20975968
10Focal adhesion_Homo sapiens_hsa045102.20439734
11Fatty acid metabolism_Homo sapiens_hsa012122.16473464
12Fatty acid degradation_Homo sapiens_hsa000712.10799227
13* Protein digestion and absorption_Homo sapiens_hsa049742.00292607
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92077756
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86120040
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.71904145
17Amoebiasis_Homo sapiens_hsa051461.67246999
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.60213629
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58195019
20Insulin resistance_Homo sapiens_hsa049311.57037172
21Viral myocarditis_Homo sapiens_hsa054161.55040089
22Adherens junction_Homo sapiens_hsa045201.43207703
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40073061
24AMPK signaling pathway_Homo sapiens_hsa041521.39251224
25Small cell lung cancer_Homo sapiens_hsa052221.38167998
26Glycerolipid metabolism_Homo sapiens_hsa005611.25854169
27Renin-angiotensin system_Homo sapiens_hsa046141.20444872
28Proteoglycans in cancer_Homo sapiens_hsa052051.18210651
29Pyruvate metabolism_Homo sapiens_hsa006201.17415595
30Renin secretion_Homo sapiens_hsa049241.17261605
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14099484
32Insulin signaling pathway_Homo sapiens_hsa049101.12374908
33Carbon metabolism_Homo sapiens_hsa012001.06632107
34Lysine degradation_Homo sapiens_hsa003101.04779278
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04726116
36Fat digestion and absorption_Homo sapiens_hsa049751.02138269
37Basal cell carcinoma_Homo sapiens_hsa052171.02051805
38Toxoplasmosis_Homo sapiens_hsa051450.98293323
39Malaria_Homo sapiens_hsa051440.97142629
40cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96726882
41Glucagon signaling pathway_Homo sapiens_hsa049220.93698939
42Type II diabetes mellitus_Homo sapiens_hsa049300.93004982
43Other glycan degradation_Homo sapiens_hsa005110.92694244
44Nitrogen metabolism_Homo sapiens_hsa009100.91263587
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90415334
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88958481
47Circadian rhythm_Homo sapiens_hsa047100.87221619
48Dorso-ventral axis formation_Homo sapiens_hsa043200.85631571
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85018375
50Gap junction_Homo sapiens_hsa045400.83042949
51Cardiac muscle contraction_Homo sapiens_hsa042600.82701942
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82646153
53beta-Alanine metabolism_Homo sapiens_hsa004100.81182057
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81042089
55Platelet activation_Homo sapiens_hsa046110.78951526
56GnRH signaling pathway_Homo sapiens_hsa049120.78775288
57Hedgehog signaling pathway_Homo sapiens_hsa043400.78476382
58Caffeine metabolism_Homo sapiens_hsa002320.78464385
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.78085871
60Calcium signaling pathway_Homo sapiens_hsa040200.77768536
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.76177474
62Histidine metabolism_Homo sapiens_hsa003400.75234633
63Pathways in cancer_Homo sapiens_hsa052000.73658821
64Pertussis_Homo sapiens_hsa051330.72730299
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.71621878
66TGF-beta signaling pathway_Homo sapiens_hsa043500.69566672
67Pancreatic secretion_Homo sapiens_hsa049720.67622233
68Tyrosine metabolism_Homo sapiens_hsa003500.67468899
69cAMP signaling pathway_Homo sapiens_hsa040240.67270763
70Glioma_Homo sapiens_hsa052140.66983279
71Notch signaling pathway_Homo sapiens_hsa043300.66857576
72HIF-1 signaling pathway_Homo sapiens_hsa040660.66580239
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66472454
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66101051
75Arginine biosynthesis_Homo sapiens_hsa002200.64412214
76Tight junction_Homo sapiens_hsa045300.63862380
77Butanoate metabolism_Homo sapiens_hsa006500.63818304
78Starch and sucrose metabolism_Homo sapiens_hsa005000.62846976
79Complement and coagulation cascades_Homo sapiens_hsa046100.62732533
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62302130
81Staphylococcus aureus infection_Homo sapiens_hsa051500.61927432
82Chronic myeloid leukemia_Homo sapiens_hsa052200.60273074
83Bile secretion_Homo sapiens_hsa049760.60123266
84Rap1 signaling pathway_Homo sapiens_hsa040150.60062498
85Melanoma_Homo sapiens_hsa052180.58330012
86Ras signaling pathway_Homo sapiens_hsa040140.58040107
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58009989
88Estrogen signaling pathway_Homo sapiens_hsa049150.56192188
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55986968
90Ovarian steroidogenesis_Homo sapiens_hsa049130.54688650
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51245053
92Phenylalanine metabolism_Homo sapiens_hsa003600.51107531
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50894700
94Renal cell carcinoma_Homo sapiens_hsa052110.49785765
95Tryptophan metabolism_Homo sapiens_hsa003800.49495407
96MicroRNAs in cancer_Homo sapiens_hsa052060.46362046
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44782689
98Prostate cancer_Homo sapiens_hsa052150.44736295
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44644082
100Hippo signaling pathway_Homo sapiens_hsa043900.44431368
101mTOR signaling pathway_Homo sapiens_hsa041500.44342713
102Acute myeloid leukemia_Homo sapiens_hsa052210.44324888
103VEGF signaling pathway_Homo sapiens_hsa043700.43692937
104Axon guidance_Homo sapiens_hsa043600.43491434
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41362962
106Salivary secretion_Homo sapiens_hsa049700.39724125
107Osteoclast differentiation_Homo sapiens_hsa043800.38876042
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38618052
109Prion diseases_Homo sapiens_hsa050200.38218791
110Prolactin signaling pathway_Homo sapiens_hsa049170.37985811
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37417428
112Oxytocin signaling pathway_Homo sapiens_hsa049210.36845545
113Melanogenesis_Homo sapiens_hsa049160.36710117
114Endometrial cancer_Homo sapiens_hsa052130.36509891
115Fatty acid elongation_Homo sapiens_hsa000620.36423706
116Arginine and proline metabolism_Homo sapiens_hsa003300.35734340
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.35731692
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35665280
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.35645111
120Gastric acid secretion_Homo sapiens_hsa049710.35478841
121ABC transporters_Homo sapiens_hsa020100.35251873
122Pancreatic cancer_Homo sapiens_hsa052120.35018697
123FoxO signaling pathway_Homo sapiens_hsa040680.34627871
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.34120377
125Thyroid hormone synthesis_Homo sapiens_hsa049180.33466387

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