COL17A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.28059304
2establishment of skin barrier (GO:0061436)8.94877621
3regulation of water loss via skin (GO:0033561)8.19598367
4keratinocyte proliferation (GO:0043616)7.37297587
5hair cycle (GO:0042633)7.28422321
6molting cycle (GO:0042303)7.28422321
7keratinocyte differentiation (GO:0030216)6.01724401
8negative regulation of keratinocyte proliferation (GO:0010839)5.84680254
9multicellular organismal water homeostasis (GO:0050891)5.79814758
10peptide cross-linking (GO:0018149)5.63692372
11* epidermis development (GO:0008544)5.39412326
12surfactant homeostasis (GO:0043129)5.35358357
13keratinocyte development (GO:0003334)5.29915589
14cell adhesion mediated by integrin (GO:0033627)5.20991276
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.19876428
16intermediate filament organization (GO:0045109)5.08108615
17viral transcription (GO:0019083)4.98675303
18dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.93568758
19ribosomal small subunit biogenesis (GO:0042274)4.89731097
20water homeostasis (GO:0030104)4.86130581
21epidermal cell differentiation (GO:0009913)4.76137515
22negative regulation of cell fate commitment (GO:0010454)4.75655394
23mesodermal cell differentiation (GO:0048333)4.72868298
24planar cell polarity pathway involved in neural tube closure (GO:0090179)4.67761369
25translational termination (GO:0006415)4.65644806
26endodermal cell differentiation (GO:0035987)4.57382646
27gap junction assembly (GO:0016264)4.51202000
28chemical homeostasis within a tissue (GO:0048875)4.45420385
29epithelial cell differentiation involved in prostate gland development (GO:0060742)4.39569976
30lateral sprouting from an epithelium (GO:0060601)4.37722771
31regulation of transforming growth factor beta2 production (GO:0032909)4.30295211
32polarized epithelial cell differentiation (GO:0030859)4.26603941
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.24342214
34regulation of phospholipase A2 activity (GO:0032429)4.18241614
35negative regulation of cell fate specification (GO:0009996)4.12666617
36* cell-substrate junction assembly (GO:0007044)4.02101263
37regulation of keratinocyte proliferation (GO:0010837)3.90037909
38renal system development (GO:0072001)3.85060527
39maturation of SSU-rRNA (GO:0030490)3.83252245
40hypotonic response (GO:0006971)3.81308381
41regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.80408032
42negative regulation of chondrocyte differentiation (GO:0032331)3.71967810
43negative regulation of epidermis development (GO:0045683)3.71721654
44ribosomal small subunit assembly (GO:0000028)3.69781457
45ventricular cardiac muscle cell action potential (GO:0086005)3.65566955
46protein localization to endosome (GO:0036010)3.63239884
47translational elongation (GO:0006414)3.59034938
48regulation of hair follicle development (GO:0051797)3.55623707
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.55419899
50viral life cycle (GO:0019058)3.54973617
51ectoderm development (GO:0007398)3.52421804
52atrioventricular valve morphogenesis (GO:0003181)3.50390106
53skin morphogenesis (GO:0043589)3.50261482
54cellular protein complex disassembly (GO:0043624)3.49719305
55protein targeting to ER (GO:0045047)3.49610184
56G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.49480478
57limb bud formation (GO:0060174)3.49476336
58renal filtration (GO:0097205)3.48478397
59peptidyl-tyrosine autophosphorylation (GO:0038083)3.47988869
60cotranslational protein targeting to membrane (GO:0006613)3.45899336
61positive regulation of gastrulation (GO:2000543)3.43627463
62gland morphogenesis (GO:0022612)3.43170472
63* cell junction assembly (GO:0034329)3.40881123
64cardiac right ventricle morphogenesis (GO:0003215)3.39990169
65hair follicle morphogenesis (GO:0031069)3.39738397
66positive regulation of odontogenesis (GO:0042482)3.39320689
67heart valve morphogenesis (GO:0003179)3.37782069
68establishment of protein localization to endoplasmic reticulum (GO:0072599)3.37588050
69odontogenesis (GO:0042476)3.33343865
70odontogenesis of dentin-containing tooth (GO:0042475)3.31346494
71cellular response to vitamin D (GO:0071305)3.29582810
72regulation of ruffle assembly (GO:1900027)3.28864390
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28137438
74regulation of cardioblast differentiation (GO:0051890)3.26264755
75* cell junction organization (GO:0034330)3.26264623
76skin development (GO:0043588)3.23531417
77outer ear morphogenesis (GO:0042473)3.22906207
78cytoskeletal anchoring at plasma membrane (GO:0007016)3.22366572
79protein localization to endoplasmic reticulum (GO:0070972)3.20214565
80regulation of hair cycle (GO:0042634)3.11445880
81non-canonical Wnt signaling pathway (GO:0035567)3.05265984
82positive regulation of epidermis development (GO:0045684)3.04561955
83regulation of cell proliferation involved in kidney development (GO:1901722)3.04272696
84intermediate filament cytoskeleton organization (GO:0045104)3.03181950
85establishment of planar polarity (GO:0001736)3.03089436
86establishment of tissue polarity (GO:0007164)3.03089436
87hair cycle process (GO:0022405)3.02844725
88molting cycle process (GO:0022404)3.02844725
89regulation of keratinocyte differentiation (GO:0045616)3.02455123
90intestinal epithelial cell development (GO:0060576)3.01877638
91L-serine transport (GO:0015825)3.00452191
92epithelial cell-cell adhesion (GO:0090136)2.98513682
93regulation of heart rate by cardiac conduction (GO:0086091)2.98278959
94morphogenesis of embryonic epithelium (GO:0016331)2.96687214
95positive regulation of hair cycle (GO:0042635)2.96078518
96positive regulation of hair follicle development (GO:0051798)2.96078518
97* epithelium development (GO:0060429)2.94648915
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.94582373
99cell communication involved in cardiac conduction (GO:0086065)2.94160735
100eyelid development in camera-type eye (GO:0061029)2.93376402
101plasma membrane repair (GO:0001778)2.92096164
102intermediate filament-based process (GO:0045103)2.91651498
103regulation of epidermis development (GO:0045682)2.91106316
104mammary gland development (GO:0030879)2.88668156
105protein complex disassembly (GO:0043241)2.88439923
106positive regulation of epidermal cell differentiation (GO:0045606)2.86294879
107glucosamine-containing compound catabolic process (GO:1901072)2.84679924
108embryonic viscerocranium morphogenesis (GO:0048703)2.83310282
109wound healing (GO:0042060)2.81578377
110sympathetic nervous system development (GO:0048485)2.80780009
111regulation of epidermal cell differentiation (GO:0045604)2.79729445
112positive regulation of cardiac muscle cell differentiation (GO:2000727)2.78626043
113regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.77266832
114heart valve formation (GO:0003188)2.76657929
115regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.72910853
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.72402752
117focal adhesion assembly (GO:0048041)2.71481218
118cell-substrate adherens junction assembly (GO:0007045)2.71481218
119cellular response to vitamin (GO:0071295)2.69992089
120negative regulation of T cell mediated immunity (GO:0002710)2.69872962
121regulation of transforming growth factor beta production (GO:0071634)2.69196403
122ribosomal large subunit biogenesis (GO:0042273)2.68534989
123* extracellular matrix disassembly (GO:0022617)2.68077466
124semaphorin-plexin signaling pathway (GO:0071526)2.68033716
125filopodium assembly (GO:0046847)2.67950935
126regulation of cell fate specification (GO:0042659)2.67172011
127positive regulation of keratinocyte differentiation (GO:0045618)2.66920925
128regulation of transforming growth factor beta1 production (GO:0032908)2.63907708
129translational initiation (GO:0006413)2.62858363
130cellular copper ion homeostasis (GO:0006878)2.61715644
131branching involved in mammary gland duct morphogenesis (GO:0060444)2.61536265
132negative regulation of cartilage development (GO:0061037)2.60252632
133hair follicle development (GO:0001942)2.60048021
134macromolecular complex disassembly (GO:0032984)2.59779361
135mammary gland epithelial cell proliferation (GO:0033598)2.59164266
136digestive tract morphogenesis (GO:0048546)2.58882428
137lymph vessel development (GO:0001945)2.58473154
138interferon-gamma secretion (GO:0072643)2.57785779
139regulation of cell fate commitment (GO:0010453)2.57207584
140negative regulation of anoikis (GO:2000811)2.56636343
141lung-associated mesenchyme development (GO:0060484)2.56388008
142ephrin receptor signaling pathway (GO:0048013)2.56170052
143serine transport (GO:0032329)2.52674380
144adherens junction organization (GO:0034332)2.50411876
145membrane tubulation (GO:0097320)2.48848686
146establishment of epithelial cell polarity (GO:0090162)2.46638362
147epithelial cell proliferation (GO:0050673)2.46625719
148regulation of endothelial cell chemotaxis (GO:2001026)2.45710610
149cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.42238838
150desmosome organization (GO:0002934)13.2285941
151* hemidesmosome assembly (GO:0031581)13.0992021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.88671320
2* SOX9_24532713_ChIP-Seq_HFSC_Mouse3.57450319
3STAT6_21828071_ChIP-Seq_BEAS2B_Human2.79469656
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.61569082
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57680161
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.48076738
7* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.46139997
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.36554266
9AR_21572438_ChIP-Seq_LNCaP_Human2.08778837
10ZNF263_19887448_ChIP-Seq_K562_Human2.06214019
11TP63_17297297_ChIP-ChIP_HaCaT_Human15.5447945
12ESR2_21235772_ChIP-Seq_MCF-7_Human1.86724126
13* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77287240
14* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77287240
15TP53_20018659_ChIP-ChIP_R1E_Mouse1.51372080
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.42386054
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.38926892
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38031273
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37121351
20CJUN_26792858_Chip-Seq_BT549_Human1.36370970
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.33248152
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32378033
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30975433
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29875549
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29727412
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28291502
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23748565
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23748565
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.23724047
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22761290
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20991387
32KLF5_25053715_ChIP-Seq_YYC3_Human1.20570577
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.19804900
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19634918
35* TP63_23658742_ChIP-Seq_EP156T_Human1.18185592
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17533156
37TP63_22573176_ChIP-Seq_HFKS_Human1.16757703
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15573558
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.14895311
40TP53_18474530_ChIP-ChIP_U2OS_Human1.14228790
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14219546
42EGR1_19032775_ChIP-ChIP_M12_Human1.12921518
43CLOCK_20551151_ChIP-Seq_293T_Human1.12897515
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12607853
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10701478
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09127481
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08879678
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08522310
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08372377
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.04292142
51RACK7_27058665_Chip-Seq_MCF-7_Human1.03743288
52* SOX2_20726797_ChIP-Seq_SW620_Human1.03666427
53AHR_22903824_ChIP-Seq_MCF-7_Human1.03485433
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01404759
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.00721368
56* UBF1/2_26484160_Chip-Seq_HMECs_Human1.00145275
57TCF4_18268006_ChIP-ChIP_LS174T_Human0.99817385
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99806080
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99647618
60CTCF_27219007_Chip-Seq_Bcells_Human0.99579178
61* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99386824
62RUNX1_27514584_Chip-Seq_MCF-7_Human0.99144022
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98980726
64RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96287754
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94778783
66TP53_16413492_ChIP-PET_HCT116_Human0.94612584
67RXR_22108803_ChIP-Seq_LS180_Human0.94346322
68GATA6_25053715_ChIP-Seq_YYC3_Human0.92932669
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91011015
70MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89638527
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84859460
72* RING1B_27294783_Chip-Seq_ESCs_Mouse0.84163534
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82802740
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82619063
75SA1_27219007_Chip-Seq_ERYTHROID_Human0.82488255
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82191701
77AR_21909140_ChIP-Seq_LNCAP_Human0.81538981
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81417940
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81338320
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81338320
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81338320
82RING1B_27294783_Chip-Seq_NPCs_Mouse0.81015689
83* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79509627
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79408465
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79255214
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79080477
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.78797477
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78444311
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78411845
90* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78181134
91* TBX20_22328084_ChIP-Seq_HEART_Mouse0.78092660
92* TBX20_22080862_ChIP-Seq_HEART_Mouse0.78092660
93ATF3_27146783_Chip-Seq_COLON_Human0.77859732
94CDX2_20551321_ChIP-Seq_CACO-2_Human0.77238824
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77068408
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.76534604
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76420675
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76169418
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75435381
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.74924561
101STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74690399
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.73583592
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.73034613
104* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72505303
105LXR_22292898_ChIP-Seq_THP-1_Human0.72424195
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.71254633
107TP53_22127205_ChIP-Seq_IMR90_Human0.70716008
108KDM2B_26808549_Chip-Seq_K562_Human0.70375051
109BCAT_22108803_ChIP-Seq_LS180_Human0.70200563
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69814369
111ELK4_26923725_Chip-Seq_MESODERM_Mouse0.69284652
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.67930452
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67574298
114GATA6_21074721_ChIP-Seq_CACO-2_Human0.67337684
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.66639877
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.66412267
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.66314461
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65396308
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.63955552
120WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.62961709
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.62653059
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.62465710
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.61976430
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.61354182
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.60413730
126* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59979923
127* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.59973291
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.59722176
129GATA4_25053715_ChIP-Seq_YYC3_Human0.59003096
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.58827155
131* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.58336671
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.58219856
133BRD4_25478319_ChIP-Seq_HGPS_Human0.56652116
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.56236221
135PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.53106414
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.51529091
137TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.51323258
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.51226794
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.49882672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.63732890
2MP0002254_reproductive_system_inflammat4.56038352
3MP0000579_abnormal_nail_morphology4.53227786
4MP0005275_abnormal_skin_tensile4.23406201
5MP0000383_abnormal_hair_follicle4.05100115
6MP0010234_abnormal_vibrissa_follicle3.87851955
7MP0003941_abnormal_skin_development3.76094177
8MP0004381_abnormal_hair_follicle3.61760929
9* MP0002060_abnormal_skin_morphology3.51680535
10MP0005501_abnormal_skin_physiology3.46962212
11MP0010678_abnormal_skin_adnexa3.26249889
12* MP0001216_abnormal_epidermal_layer3.13934190
13MP0000762_abnormal_tongue_morphology3.13155436
14MP0002098_abnormal_vibrissa_morphology3.02818874
15MP0000467_abnormal_esophagus_morphology3.01868565
16MP0003705_abnormal_hypodermis_morpholog3.00602716
17MP0000427_abnormal_hair_cycle2.91276148
18MP0000647_abnormal_sebaceous_gland2.87829274
19MP0003453_abnormal_keratinocyte_physiol2.76454439
20MP0001346_abnormal_lacrimal_gland2.56762156
21* MP0010771_integument_phenotype2.55697750
22MP0000377_abnormal_hair_follicle2.47758781
23MP0009379_abnormal_foot_pigmentation2.18651434
24MP0003566_abnormal_cell_adhesion2.13901440
25MP0004264_abnormal_extraembryonic_tissu2.04823691
26MP0000566_synostosis2.04242133
27MP0004947_skin_inflammation2.04046823
28MP0001849_ear_inflammation1.99813803
29MP0002234_abnormal_pharynx_morphology1.96622589
30MP0010030_abnormal_orbit_morphology1.84101484
31MP0001851_eye_inflammation1.78376095
32MP0002009_preneoplasia1.66106386
33MP0001243_abnormal_dermal_layer1.52961424
34MP0008789_abnormal_olfactory_epithelium1.52558425
35* MP0009931_abnormal_skin_appearance1.51475859
36MP0008260_abnormal_autophagy1.50884358
37MP0005360_urolithiasis1.45174747
38MP0005451_abnormal_body_composition1.40290867
39* MP0001191_abnormal_skin_condition1.39345445
40MP0001340_abnormal_eyelid_morphology1.38041939
41MP0002249_abnormal_larynx_morphology1.32311744
42MP0005409_darkened_coat_color1.24315455
43MP0009053_abnormal_anal_canal1.24129266
44MP0002282_abnormal_trachea_morphology1.22791334
45MP0003191_abnormal_cellular_cholesterol1.18858396
46MP0005499_abnormal_olfactory_system1.17780753
47MP0005394_taste/olfaction_phenotype1.17780753
48MP0003136_yellow_coat_color1.14765358
49MP0000537_abnormal_urethra_morphology1.11532333
50MP0003755_abnormal_palate_morphology1.11117970
51* MP0000367_abnormal_coat/_hair1.09914846
52MP0002233_abnormal_nose_morphology1.04490781
53MP0000465_gastrointestinal_hemorrhage1.02364325
54MP0005023_abnormal_wound_healing1.01251764
55MP0004185_abnormal_adipocyte_glucose0.96167512
56MP0004272_abnormal_basement_membrane0.95022485
57MP0000538_abnormal_urinary_bladder0.93693921
58MP0002177_abnormal_outer_ear0.93381061
59MP0000627_abnormal_mammary_gland0.91937825
60MP0009250_abnormal_appendicular_skeleto0.91711317
61MP0002877_abnormal_melanocyte_morpholog0.91209422
62MP0005508_abnormal_skeleton_morphology0.86471228
63MP0000678_abnormal_parathyroid_gland0.85304539
64MP0009780_abnormal_chondrocyte_physiolo0.82148647
65MP0005076_abnormal_cell_differentiation0.78139212
66MP0009384_cardiac_valve_regurgitation0.74613855
67MP0004019_abnormal_vitamin_homeostasis0.73938808
68MP0002089_abnormal_postnatal_growth/wei0.72412084
69MP0000049_abnormal_middle_ear0.72027948
70MP0002102_abnormal_ear_morphology0.68449973
71MP0010352_gastrointestinal_tract_polyps0.67621160
72MP0000428_abnormal_craniofacial_morphol0.66517383
73MP0000858_altered_metastatic_potential0.66123349
74MP0003011_delayed_dark_adaptation0.65922045
75MP0000432_abnormal_head_morphology0.65743618
76MP0003045_fibrosis0.63894217
77MP0003329_amyloid_beta_deposits0.62570480
78MP0005257_abnormal_intraocular_pressure0.62546059
79MP0002277_abnormal_respiratory_mucosa0.62521222
80MP0000462_abnormal_digestive_system0.62318222
81MP0005503_abnormal_tendon_morphology0.61941724
82MP0002896_abnormal_bone_mineralization0.61566117
83MP0002095_abnormal_skin_pigmentation0.60645139
84MP0002111_abnormal_tail_morphology0.59710728
85MP0003937_abnormal_limbs/digits/tail_de0.58879038
86MP0001958_emphysema0.58658823
87MP0002166_altered_tumor_susceptibility0.58207224
88MP0003950_abnormal_plasma_membrane0.57878502
89MP0004782_abnormal_surfactant_physiolog0.57866340
90MP0001299_abnormal_eye_distance/0.57277797
91MP0004885_abnormal_endolymph0.56895656
92MP0008438_abnormal_cutaneous_collagen0.56857357
93MP0000613_abnormal_salivary_gland0.56526732
94MP0003315_abnormal_perineum_morphology0.55979098
95MP0002108_abnormal_muscle_morphology0.55334681
96MP0003091_abnormal_cell_migration0.53536537
97MP0001270_distended_abdomen0.52828433
98MP0000470_abnormal_stomach_morphology0.52073945
99MP0003385_abnormal_body_wall0.52050573
100MP0010368_abnormal_lymphatic_system0.48442369
101MP0003300_gastrointestinal_ulcer0.48415420
102MP0002109_abnormal_limb_morphology0.48323435
103MP0006138_congestive_heart_failure0.48074407
104MP0003935_abnormal_craniofacial_develop0.47882263
105MP0002006_tumorigenesis0.47330294
106MP0001784_abnormal_fluid_regulation0.46944558
107MP0003938_abnormal_ear_development0.46639935
108MP0005193_abnormal_anterior_eye0.45662680
109MP0005390_skeleton_phenotype0.44199844
110MP0003183_abnormal_peptide_metabolism0.44138253
111MP0004858_abnormal_nervous_system0.43794531
112MP0005197_abnormal_uvea_morphology0.43701762
113MP0002132_abnormal_respiratory_system0.40755089
114MP0005367_renal/urinary_system_phenotyp0.40369607
115MP0000516_abnormal_urinary_system0.40369607
116MP0000015_abnormal_ear_pigmentation0.40237625
117MP0001765_abnormal_ion_homeostasis0.38648735
118MP0002697_abnormal_eye_size0.37826952
119MP0000163_abnormal_cartilage_morphology0.37612708
120MP0005075_abnormal_melanosome_morpholog0.36553338
121MP0005621_abnormal_cell_physiology0.36041805
122MP0000003_abnormal_adipose_tissue0.35997525
123MP0000013_abnormal_adipose_tissue0.35825500
124MP0002116_abnormal_craniofacial_bone0.34340133
125MP0003448_altered_tumor_morphology0.33759900
126MP0004134_abnormal_chest_morphology0.31267347
127MP0003638_abnormal_response/metabolism_0.30537881
128MP0004197_abnormal_fetal_growth/weight/0.29580731
129MP0002133_abnormal_respiratory_system0.28452451
130MP0005388_respiratory_system_phenotype0.28452451

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)8.50511678
2Onycholysis (HP:0001806)7.16717007
3* Fragile nails (HP:0001808)7.14065200
4* Plantar hyperkeratosis (HP:0007556)6.64558596
5Hypotrichosis (HP:0001006)6.21442528
6Atrophic scars (HP:0001075)6.11225761
7Thick nail (HP:0001805)5.43569319
8Palmoplantar hyperkeratosis (HP:0000972)5.36477969
9Woolly hair (HP:0002224)5.12167327
10Palmar hyperkeratosis (HP:0010765)5.05893224
11Pili torti (HP:0003777)4.85424304
12Nail dystrophy (HP:0008404)4.51114021
13Right ventricular cardiomyopathy (HP:0011663)4.50691212
14Abnormality of nail color (HP:0100643)4.46672088
15* Abnormal blistering of the skin (HP:0008066)4.18331551
16Ridged nail (HP:0001807)4.07736746
17Alopecia of scalp (HP:0002293)3.94520711
18Down-sloping shoulders (HP:0200021)3.91541182
19Fragile skin (HP:0001030)3.79890212
20Parakeratosis (HP:0001036)3.75070540
21Lip pit (HP:0100267)3.74025893
22Aplasia cutis congenita (HP:0001057)3.66268551
23Distal lower limb muscle weakness (HP:0009053)3.61652852
24Selective tooth agenesis (HP:0001592)3.53956879
25Erythema (HP:0010783)3.50386673
26Increased IgE level (HP:0003212)3.28143701
27Amyloidosis (HP:0011034)3.19364434
28Esophageal atresia (HP:0002032)3.11049357
29Fatigable weakness (HP:0003473)3.10366927
30Abnormality of the neuromuscular junction (HP:0003398)3.10366927
31Hypoplasia of dental enamel (HP:0006297)3.07534170
32Abnormal hair laboratory examination (HP:0003328)2.99109055
33Dry hair (HP:0011359)2.94969503
34Sparse eyelashes (HP:0000653)2.93554671
35Natal tooth (HP:0000695)2.88204364
36Increased connective tissue (HP:0009025)2.87332296
37Oral leukoplakia (HP:0002745)2.86604036
38Concave nail (HP:0001598)2.83487772
39Abnormality of cells of the erythroid lineage (HP:0012130)2.77300719
40Congenital ichthyosiform erythroderma (HP:0007431)2.74841709
41Ectropion (HP:0000656)2.73536860
42Sparse scalp hair (HP:0002209)2.73294491
43Advanced eruption of teeth (HP:0006288)2.72997926
44Amniotic constriction ring (HP:0009775)2.68904280
45Abnormality of placental membranes (HP:0011409)2.68904280
46Aplasia involving bones of the extremities (HP:0009825)2.64392215
47Aplasia involving bones of the upper limbs (HP:0009823)2.64392215
48Aplasia of the phalanges of the hand (HP:0009802)2.64392215
49Pterygium (HP:0001059)2.63180745
50Absent eyelashes (HP:0000561)2.57592450
51Erythroderma (HP:0001019)2.54890206
52Corneal erosion (HP:0200020)2.52419956
53Abnormality of the axillary hair (HP:0100134)2.50757506
54Abnormality of secondary sexual hair (HP:0009888)2.50757506
55Acanthosis nigricans (HP:0000956)2.49542610
56Hyporeflexia of lower limbs (HP:0002600)2.44582452
57Abnormal hemoglobin (HP:0011902)2.43190546
58Amelogenesis imperfecta (HP:0000705)2.42484827
59Hypohidrosis (HP:0000966)2.41842555
60Ankyloglossia (HP:0010296)2.37439003
61Abnormality of the distal phalanges of the toes (HP:0010182)2.29732679
62Abnormality of oral frenula (HP:0000190)2.29061948
63Premature loss of primary teeth (HP:0006323)2.27248230
64Abnormal number of erythroid precursors (HP:0012131)2.19722730
65Palmoplantar keratoderma (HP:0000982)2.17540160
66Blepharitis (HP:0000498)2.16649147
67Ventricular tachycardia (HP:0004756)2.16480338
68Popliteal pterygium (HP:0009756)2.16373886
69Hypoplastic labia majora (HP:0000059)2.15887245
70Pruritus (HP:0000989)2.15435674
71Conjunctival hamartoma (HP:0100780)2.12122280
72Follicular hyperkeratosis (HP:0007502)2.11956821
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10174335
74Bronchomalacia (HP:0002780)2.10171023
75Anonychia (HP:0001798)2.05975018
76Dehydration (HP:0001944)2.02259542
77Conical tooth (HP:0000698)2.01918653
78Absent eyebrow (HP:0002223)2.00624366
79* Hypodontia (HP:0000668)1.99748716
80Obstructive sleep apnea (HP:0002870)1.98400088
81* Abnormality of the fingernails (HP:0001231)1.95821203
82Abnormality of the labia majora (HP:0012881)1.94090319
83Curly hair (HP:0002212)1.93904830
84Ureteral obstruction (HP:0006000)1.92691650
85Cheilitis (HP:0100825)1.91947057
86Severe Myopia (HP:0011003)1.91050850
87Premature rupture of membranes (HP:0001788)1.89353627
88Distal lower limb amyotrophy (HP:0008944)1.87743800
89Oligodontia (HP:0000677)1.87145569
90Congenital, generalized hypertrichosis (HP:0004540)1.85419547
91Neurofibrillary tangles (HP:0002185)1.84883826
92Gangrene (HP:0100758)1.84628866
93Hoarse voice (HP:0001609)1.83855240
94Short nail (HP:0001799)1.83703859
95Breast hypoplasia (HP:0003187)1.83437380
96Abnormality of the salivary glands (HP:0010286)1.82973567
97Reticulocytopenia (HP:0001896)1.81679120
98Septate vagina (HP:0001153)1.79261827
99* Hyperhidrosis (HP:0000975)1.77793667
100Split foot (HP:0001839)1.77768274
101Type 1 muscle fiber predominance (HP:0003803)1.77280786
102Abnormality of permanent molar morphology (HP:0011071)1.76868677
103Abnormality of the dental root (HP:0006486)1.76868677
104Taurodontia (HP:0000679)1.76868677
105Laryngomalacia (HP:0001601)1.76531275
106Abnormality of the 2nd finger (HP:0004100)1.73524061
107Xerostomia (HP:0000217)1.72597468
108Mixed hearing impairment (HP:0000410)1.71945158
109Death in infancy (HP:0001522)1.71897989
110Duplicated collecting system (HP:0000081)1.70373032
111Morphological abnormality of the middle ear (HP:0008609)1.70354533
112Epidermoid cyst (HP:0200040)1.69713203
113Abnormality of the middle phalanges of the toes (HP:0010183)1.68770319
114Labial hypoplasia (HP:0000066)1.68633096
115Skin ulcer (HP:0200042)1.66732697
116Nasolacrimal duct obstruction (HP:0000579)1.66533777
117Round ear (HP:0100830)1.66166294
118Upper limb muscle weakness (HP:0003484)1.63867708
119Abnormality of molar morphology (HP:0011070)1.63333541
120Abnormality of molar (HP:0011077)1.63333541
121Shallow orbits (HP:0000586)1.63115850
122Abnormality of the nasal septum (HP:0000419)1.62960472
123Ureteral stenosis (HP:0000071)1.62878968
124* Carious teeth (HP:0000670)1.62502662
125Macrocytic anemia (HP:0001972)1.62466503
126Broad face (HP:0000283)1.62165040
127Corneal dystrophy (HP:0001131)1.61831844
128Periodontitis (HP:0000704)1.61480330
129Neonatal death (HP:0003811)1.58787618
130Flat acetabular roof (HP:0003180)1.56023540
131Hypoplastic female external genitalia (HP:0012815)1.55349856
132Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.55073429
133Malnutrition (HP:0004395)1.53066639
134Abnormality of the dental pulp (HP:0006479)1.50720019
135Cerebral inclusion bodies (HP:0100314)1.48866459
136Trismus (HP:0000211)1.48150550
137Vertebral arch anomaly (HP:0008438)1.46730011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.80547692
2MAP3K34.61054699
3MAPKAPK34.56693413
4EPHB24.10478308
5ARAF4.06386782
6ERN13.86922434
7MAP3K23.15927447
8FER2.95753980
9FGFR22.87015668
10LATS12.58062405
11NTRK12.51315939
12RPS6KB22.43223730
13MST42.14037562
14EPHA31.86886968
15LRRK21.82923168
16LMTK21.82201465
17TRPM71.81419700
18EEF2K1.76718373
19MAP3K91.74462172
20KSR21.69979997
21STK241.69168453
22PDGFRA1.54361863
23PIK3CG1.48279378
24MET1.42562231
25FGFR41.40512097
26PAK41.38809268
27BMPR1B1.36399563
28FLT31.33064301
29MAP3K11.32691229
30TYK21.27187007
31MAPKAPK51.26739132
32FGFR11.26721194
33EPHA21.26183761
34BCR1.25554753
35EPHB11.21775966
36BRAF1.21239382
37CSF1R1.21181345
38FGFR31.17715222
39TTN1.15527891
40PTK61.12520735
41CDK121.09195957
42SMG11.04390196
43PNCK1.03269772
44RAF11.02440433
45PDGFRB1.01897486
46PIM20.97408057
47SIK10.96921002
48HIPK20.95014731
49MAPK150.94175615
50ERBB30.91959194
51RET0.90588714
52PRPF4B0.90419362
53TGFBR10.90109574
54MAP2K60.88567890
55OBSCN0.85392072
56CDK60.85247604
57PRKD10.83189276
58DYRK1B0.81295287
59MAPKAPK20.81116071
60NME10.79772871
61LATS20.79729471
62CDK30.79426033
63BMX0.76646940
64MAP2K20.76092954
65MAP2K10.73623993
66PBK0.73426538
67NTRK20.73112017
68FGR0.69516536
69MAP3K130.67745313
70STK380.67293701
71MAP3K140.65994239
72NUAK10.65532955
73PTK2B0.62600236
74TGFBR20.61796442
75MAP3K120.61749161
76STK100.61631962
77MAP3K70.60040696
78TAOK10.59136033
79IRAK30.58382949
80IRAK10.58028771
81IKBKB0.56897677
82RPS6KA10.56422270
83MAPK110.55957169
84ROCK10.55211925
85ILK0.54391733
86PKN20.53348926
87RPS6KA40.53337157
88EPHA40.53016599
89CAMK1G0.52125757
90STK110.51968653
91RIPK10.51248068
92TRIB30.50975508
93ERBB20.48780763
94NME20.47924537
95NEK60.47638820
96MTOR0.45962985
97PRKCE0.45460458
98NLK0.44482461
99ITK0.43629117
100PRKCI0.43492740
101STK30.42219770
102CDC42BPA0.41991851
103DAPK20.39776317
104MAPK120.39673869
105KSR10.39386907
106IKBKE0.39335681
107RPS6KB10.38838754
108PRKD20.38788576
109PTK20.38700078
110WNK10.36345209
111MAP2K30.35023878
112MAP3K110.33685799
113MAP3K80.33341739
114CSNK1D0.33028046
115JAK20.31777027
116MAPK40.31056705
117MATK0.30958455
118ROCK20.30790491
119RPS6KA60.30629443
120PIK3CA0.30394739
121MOS0.30250502
122IGF1R0.29650221
123RPS6KA20.29565036
124TESK10.27862296
125HCK0.27556537
126MAP3K60.27284373
127DMPK0.27171185
128RPS6KL10.26937826
129RPS6KC10.26937826
130GSK3A0.26753775
131ICK0.26499387
132MAPK30.25824800
133IRAK20.25276094
134CHUK0.24631844
135GRK70.24627632
136STK38L0.23444090
137CLK10.23366730
138ADRBK10.22753261
139BMPR20.22177360
140MAPK90.21509077
141JAK30.20338020
142INSR0.19585585
143MAPK70.19391895
144ABL20.18014012
145SRC0.17442367
146PRKG20.14898336
147FYN0.14411288

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.22737859
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.78762697
3Basal cell carcinoma_Homo sapiens_hsa052173.56027750
4ECM-receptor interaction_Homo sapiens_hsa045122.95882422
5Hedgehog signaling pathway_Homo sapiens_hsa043402.77779277
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.18373012
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.12900272
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.09171168
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97143793
10Amoebiasis_Homo sapiens_hsa051461.94137492
11Hippo signaling pathway_Homo sapiens_hsa043901.89367731
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.80929611
13Melanogenesis_Homo sapiens_hsa049161.74543434
14Linoleic acid metabolism_Homo sapiens_hsa005911.72789358
15Proteoglycans in cancer_Homo sapiens_hsa052051.68292310
16Phenylalanine metabolism_Homo sapiens_hsa003601.64269524
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63666172
18Axon guidance_Homo sapiens_hsa043601.61496680
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58352449
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47475923
21Wnt signaling pathway_Homo sapiens_hsa043101.43544257
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40769300
23Adherens junction_Homo sapiens_hsa045201.38428200
24Steroid biosynthesis_Homo sapiens_hsa001001.38194325
25Bladder cancer_Homo sapiens_hsa052191.34226260
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33454787
27Small cell lung cancer_Homo sapiens_hsa052221.31483347
28Sphingolipid metabolism_Homo sapiens_hsa006001.29412614
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29305877
30Toxoplasmosis_Homo sapiens_hsa051451.28058723
31Phototransduction_Homo sapiens_hsa047441.28005152
32Arachidonic acid metabolism_Homo sapiens_hsa005901.26984509
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26018820
34TGF-beta signaling pathway_Homo sapiens_hsa043501.19195278
35Renin secretion_Homo sapiens_hsa049241.16264451
36Notch signaling pathway_Homo sapiens_hsa043301.14791865
37Chemical carcinogenesis_Homo sapiens_hsa052041.12767239
38Focal adhesion_Homo sapiens_hsa045101.12406613
39Chronic myeloid leukemia_Homo sapiens_hsa052201.11236038
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10994564
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10819637
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09172212
43Tight junction_Homo sapiens_hsa045301.09131386
44GnRH signaling pathway_Homo sapiens_hsa049121.04124540
45Histidine metabolism_Homo sapiens_hsa003401.03454439
46Pancreatic cancer_Homo sapiens_hsa052121.01117709
47Prion diseases_Homo sapiens_hsa050200.97810540
48VEGF signaling pathway_Homo sapiens_hsa043700.97278625
49Dilated cardiomyopathy_Homo sapiens_hsa054140.96465486
50Renal cell carcinoma_Homo sapiens_hsa052110.96170637
51* Protein digestion and absorption_Homo sapiens_hsa049740.95584090
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95393467
53Pathways in cancer_Homo sapiens_hsa052000.95284406
54Gastric acid secretion_Homo sapiens_hsa049710.93590794
55Inositol phosphate metabolism_Homo sapiens_hsa005620.92579628
56Retinol metabolism_Homo sapiens_hsa008300.91915899
57MicroRNAs in cancer_Homo sapiens_hsa052060.90725411
58Tyrosine metabolism_Homo sapiens_hsa003500.90496053
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88863193
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.88685226
61Shigellosis_Homo sapiens_hsa051310.84019516
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82393287
63Insulin signaling pathway_Homo sapiens_hsa049100.82203459
64p53 signaling pathway_Homo sapiens_hsa041150.80903169
65Salivary secretion_Homo sapiens_hsa049700.80771174
66N-Glycan biosynthesis_Homo sapiens_hsa005100.79375949
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76650378
68Vitamin digestion and absorption_Homo sapiens_hsa049770.76328414
69Ether lipid metabolism_Homo sapiens_hsa005650.76157083
70Salmonella infection_Homo sapiens_hsa051320.74364952
71Pancreatic secretion_Homo sapiens_hsa049720.74192964
72Galactose metabolism_Homo sapiens_hsa000520.73813007
73Rap1 signaling pathway_Homo sapiens_hsa040150.71482614
74Fatty acid elongation_Homo sapiens_hsa000620.70937659
75Circadian rhythm_Homo sapiens_hsa047100.70801144
76Hepatitis C_Homo sapiens_hsa051600.70381384
77Mineral absorption_Homo sapiens_hsa049780.69755492
78Endocytosis_Homo sapiens_hsa041440.69615713
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69080548
80Acute myeloid leukemia_Homo sapiens_hsa052210.67409512
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.67351274
82Non-small cell lung cancer_Homo sapiens_hsa052230.66465658
83Glycerolipid metabolism_Homo sapiens_hsa005610.65148719
84Platelet activation_Homo sapiens_hsa046110.64781456
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63179271
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62529932
87Staphylococcus aureus infection_Homo sapiens_hsa051500.62347728
88Hematopoietic cell lineage_Homo sapiens_hsa046400.62085771
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62085453
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.61762651
91Ras signaling pathway_Homo sapiens_hsa040140.61420610
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.60467699
93Oxytocin signaling pathway_Homo sapiens_hsa049210.60000418
94Malaria_Homo sapiens_hsa051440.59913170
95Sulfur metabolism_Homo sapiens_hsa009200.59817150
96TNF signaling pathway_Homo sapiens_hsa046680.59622019
97HTLV-I infection_Homo sapiens_hsa051660.58701169
98Melanoma_Homo sapiens_hsa052180.58012984
99Insulin resistance_Homo sapiens_hsa049310.57385358
100Long-term depression_Homo sapiens_hsa047300.56011266
101Thyroid cancer_Homo sapiens_hsa052160.55903514
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.55692851
103Caffeine metabolism_Homo sapiens_hsa002320.55304595
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55108981
105Calcium signaling pathway_Homo sapiens_hsa040200.54195757
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.53804585
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53752575
108Dorso-ventral axis formation_Homo sapiens_hsa043200.52369708
109Choline metabolism in cancer_Homo sapiens_hsa052310.52289894
110ErbB signaling pathway_Homo sapiens_hsa040120.51671365
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50915655
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.49781673
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48048375
114Fatty acid biosynthesis_Homo sapiens_hsa000610.47891281
115Endometrial cancer_Homo sapiens_hsa052130.47813110
116Estrogen signaling pathway_Homo sapiens_hsa049150.47045126
117Pertussis_Homo sapiens_hsa051330.44735231
118Bile secretion_Homo sapiens_hsa049760.44495448
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.43143998
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.42959764
121Osteoclast differentiation_Homo sapiens_hsa043800.42676731
122ABC transporters_Homo sapiens_hsa020100.42519755
123Lysosome_Homo sapiens_hsa041420.42157787
124Glioma_Homo sapiens_hsa052140.42140720
125Ovarian steroidogenesis_Homo sapiens_hsa049130.41712281
126Glucagon signaling pathway_Homo sapiens_hsa049220.40922254
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39323947
128Prostate cancer_Homo sapiens_hsa052150.39260057
129Serotonergic synapse_Homo sapiens_hsa047260.37919438
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37194781
131MAPK signaling pathway_Homo sapiens_hsa040100.37167828
132PPAR signaling pathway_Homo sapiens_hsa033200.36751676
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.36742885
134Fat digestion and absorption_Homo sapiens_hsa049750.36432985
135Apoptosis_Homo sapiens_hsa042100.35585425
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.35380836

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