COL18A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.99427247
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.99427247
3L-phenylalanine metabolic process (GO:0006558)6.76519610
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.76519610
5aromatic amino acid family catabolic process (GO:0009074)6.21474431
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.94653856
7negative regulation of fibrinolysis (GO:0051918)5.64834049
8glyoxylate metabolic process (GO:0046487)5.62823271
9alpha-linolenic acid metabolic process (GO:0036109)5.61457163
10kynurenine metabolic process (GO:0070189)5.60271790
11indole-containing compound catabolic process (GO:0042436)5.53861642
12indolalkylamine catabolic process (GO:0046218)5.53861642
13tryptophan catabolic process (GO:0006569)5.53861642
14bile acid biosynthetic process (GO:0006699)5.47251490
15urea cycle (GO:0000050)5.41803111
16urea metabolic process (GO:0019627)5.41803111
17protein carboxylation (GO:0018214)5.31441452
18peptidyl-glutamic acid carboxylation (GO:0017187)5.31441452
19regulation of fibrinolysis (GO:0051917)5.29185710
20tryptophan metabolic process (GO:0006568)5.25177625
21sulfur amino acid catabolic process (GO:0000098)5.24048278
22regulation of protein activation cascade (GO:2000257)5.22307442
23high-density lipoprotein particle remodeling (GO:0034375)5.16574209
24cysteine metabolic process (GO:0006534)5.12368412
25complement activation, alternative pathway (GO:0006957)5.10853797
26serine family amino acid catabolic process (GO:0009071)5.02914339
27nitrogen cycle metabolic process (GO:0071941)4.91550363
28regulation of complement activation (GO:0030449)4.88705110
29basement membrane organization (GO:0071711)4.83620745
30homocysteine metabolic process (GO:0050667)4.81369752
31reverse cholesterol transport (GO:0043691)4.72938256
32bile acid metabolic process (GO:0008206)4.66727754
33lysine metabolic process (GO:0006553)4.62672256
34lysine catabolic process (GO:0006554)4.62672256
35glycine metabolic process (GO:0006544)4.55217877
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.53194740
37aromatic amino acid family metabolic process (GO:0009072)4.46709491
38negative regulation of cholesterol transport (GO:0032375)4.46492818
39negative regulation of sterol transport (GO:0032372)4.46492818
40tyrosine metabolic process (GO:0006570)4.42293736
41plasma lipoprotein particle remodeling (GO:0034369)4.41953712
42protein-lipid complex remodeling (GO:0034368)4.41953712
43macromolecular complex remodeling (GO:0034367)4.41953712
44amino-acid betaine metabolic process (GO:0006577)4.40944250
45acylglycerol homeostasis (GO:0055090)4.40558120
46triglyceride homeostasis (GO:0070328)4.40558120
47regulation of triglyceride catabolic process (GO:0010896)4.40512700
48alpha-amino acid catabolic process (GO:1901606)4.37141063
49regulation of cholesterol esterification (GO:0010872)4.36386964
50plasma lipoprotein particle clearance (GO:0034381)4.33853400
51planar cell polarity pathway involved in neural tube closure (GO:0090179)4.18888720
52imidazole-containing compound metabolic process (GO:0052803)4.17914735
53phospholipid efflux (GO:0033700)4.17817829
54serine family amino acid metabolic process (GO:0009069)4.13654176
55fibrinolysis (GO:0042730)4.08310870
56cellular amino acid catabolic process (GO:0009063)4.00806376
57ethanol oxidation (GO:0006069)3.97792016
58regulation of cholesterol homeostasis (GO:2000188)3.96326132
59glutamate metabolic process (GO:0006536)3.95377615
60bile acid and bile salt transport (GO:0015721)3.94562276
61serine family amino acid biosynthetic process (GO:0009070)3.94446652
62cellular modified amino acid catabolic process (GO:0042219)3.94243707
63arginine metabolic process (GO:0006525)3.89760950
64dicarboxylic acid biosynthetic process (GO:0043650)3.89200629
65cholesterol efflux (GO:0033344)3.84692073
66coenzyme catabolic process (GO:0009109)3.83815117
67indolalkylamine metabolic process (GO:0006586)3.83208706
68regulation of apoptotic cell clearance (GO:2000425)3.82207715
69cellular glucuronidation (GO:0052695)3.80683824
70regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.80371702
71cellular ketone body metabolic process (GO:0046950)3.78698905
72plasma lipoprotein particle assembly (GO:0034377)3.77403848
73benzene-containing compound metabolic process (GO:0042537)3.77334118
74positive regulation of fatty acid beta-oxidation (GO:0032000)3.69021498
75amine catabolic process (GO:0009310)3.67002557
76cellular biogenic amine catabolic process (GO:0042402)3.67002557
77semaphorin-plexin signaling pathway (GO:0071526)3.65210892
78endodermal cell differentiation (GO:0035987)3.61408326
79cholesterol homeostasis (GO:0042632)3.61033033
80positive regulation of lipid catabolic process (GO:0050996)3.59878666
81phospholipid homeostasis (GO:0055091)3.58733169
82drug catabolic process (GO:0042737)3.56395910
83sterol homeostasis (GO:0055092)3.56013761
84lipoprotein metabolic process (GO:0042157)3.55420030
85aldehyde catabolic process (GO:0046185)3.55120611
86acetyl-CoA metabolic process (GO:0006084)3.52904767
87low-density lipoprotein particle remodeling (GO:0034374)3.52861548
88blood coagulation, intrinsic pathway (GO:0007597)3.51310035
89complement activation, classical pathway (GO:0006958)3.50483112
90positive regulation of lipoprotein lipase activity (GO:0051006)3.50090908
91positive regulation of triglyceride lipase activity (GO:0061365)3.50090908
92negative regulation of lipase activity (GO:0060192)3.48489321
93response to nitrosative stress (GO:0051409)3.48188796
94complement activation (GO:0006956)3.48053819
95regulation of bile acid biosynthetic process (GO:0070857)3.47129982
96adherens junction assembly (GO:0034333)3.46056679
97regulation of plasminogen activation (GO:0010755)3.45991744
98carboxylic acid catabolic process (GO:0046395)3.44952951
99organic acid catabolic process (GO:0016054)3.44952951
100protein activation cascade (GO:0072376)3.44356254
101protein-lipid complex assembly (GO:0065005)3.42994058
102very-low-density lipoprotein particle assembly (GO:0034379)3.40991604
103vascular endothelial growth factor signaling pathway (GO:0038084)3.40889807
104epithelial cell-cell adhesion (GO:0090136)3.39544039
105atrioventricular valve morphogenesis (GO:0003181)3.38063443
106plasma lipoprotein particle organization (GO:0071827)3.34026747
107uronic acid metabolic process (GO:0006063)3.31904427
108glucuronate metabolic process (GO:0019585)3.31904427
109cytolysis (GO:0019835)3.31543615
110aspartate family amino acid catabolic process (GO:0009068)3.29543784
111cell-substrate junction assembly (GO:0007044)3.29026628
112endothelium development (GO:0003158)3.25714176
113branching involved in salivary gland morphogenesis (GO:0060445)3.20676462
114focal adhesion assembly (GO:0048041)3.20091525
115cell-substrate adherens junction assembly (GO:0007045)3.20091525
116retina vasculature morphogenesis in camera-type eye (GO:0061299)3.19249233
117negative regulation of fatty acid transport (GO:2000192)3.14586109
118regulation of cardioblast differentiation (GO:0051890)3.10068208
119paraxial mesoderm development (GO:0048339)3.02998103
120COPI coating of Golgi vesicle (GO:0048205)3.01338859
121Golgi transport vesicle coating (GO:0048200)3.01338859
122gap junction assembly (GO:0016264)3.00259178
123protein retention in ER lumen (GO:0006621)3.00023917
124cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.99417714
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.97076776
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.96181790
127convergent extension (GO:0060026)2.94868837
128desmosome organization (GO:0002934)2.91185983
129apoptotic process involved in morphogenesis (GO:0060561)2.91164132
130hemidesmosome assembly (GO:0031581)2.89190336
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87209583
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.86127539
133negative regulation of chondrocyte differentiation (GO:0032331)2.83134652
134regulation of glucose import in response to insulin stimulus (GO:2001273)2.82328901
135positive regulation of receptor recycling (GO:0001921)2.80628487
136vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.79518320
137Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.73974947
138renal filtration (GO:0097205)2.73632695
139establishment of apical/basal cell polarity (GO:0035089)2.73073201
140protein heterotrimerization (GO:0070208)2.71730517
141chondrocyte proliferation (GO:0035988)2.69169685
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.68862344
143regulation of extracellular matrix disassembly (GO:0010715)2.68015013
144blood vessel endothelial cell migration (GO:0043534)2.67962726
145skin morphogenesis (GO:0043589)2.67904622
146* collagen metabolic process (GO:0032963)2.63513642
147cell migration involved in heart development (GO:0060973)2.60882490
148cell-cell junction maintenance (GO:0045217)2.60734226
149positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60690410
150cell adhesion mediated by integrin (GO:0033627)2.58366623
151collagen fibril organization (GO:0030199)2.57689661
152regulation of establishment of planar polarity (GO:0090175)2.56830404
153* extracellular matrix disassembly (GO:0022617)2.56492465
154lymphangiogenesis (GO:0001946)2.55707075
155cell migration involved in sprouting angiogenesis (GO:0002042)2.52176804
156dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51423347
157* multicellular organismal macromolecule metabolic process (GO:0044259)2.50642048
158cell proliferation involved in metanephros development (GO:0072203)2.49068420
159glomerular filtration (GO:0003094)2.48873828
160negative regulation of blood coagulation (GO:0030195)2.47011867
161negative regulation of hemostasis (GO:1900047)2.47011867
162apoptotic cell clearance (GO:0043277)2.44383297
163bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43699145
164* collagen catabolic process (GO:0030574)2.43262789
165glomerular visceral epithelial cell development (GO:0072015)2.42708600
166regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.42242883
167negative regulation of cell fate specification (GO:0009996)2.41501492
168wound healing, spreading of epidermal cells (GO:0035313)2.41486101
169positive regulation of osteoblast proliferation (GO:0033690)2.39716059
170negative regulation of lipid transport (GO:0032369)2.38558693
171non-canonical Wnt signaling pathway (GO:0035567)2.37939795
172renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.37719588
173proline metabolic process (GO:0006560)2.37627682
174G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.36273253
175negative regulation of catenin import into nucleus (GO:0035414)2.35875851
176* multicellular organismal metabolic process (GO:0044236)2.34088458
177protein localization to endosome (GO:0036010)2.34068264
178negative regulation of wound healing (GO:0061045)2.32647513
179endothelial cell chemotaxis (GO:0035767)2.32594423
180positive regulation of hormone metabolic process (GO:0032352)2.32507189
181glomerular basement membrane development (GO:0032836)2.32390929
182substrate adhesion-dependent cell spreading (GO:0034446)2.30307098
183venous blood vessel morphogenesis (GO:0048845)2.30209671
184* endothelial cell morphogenesis (GO:0001886)2.30081386
185negative regulation of coagulation (GO:0050819)2.30062477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.49291162
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.57306057
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.86081231
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.64257218
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89288514
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.56382866
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.17020499
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.81663517
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.15165914
10* CLOCK_20551151_ChIP-Seq_293T_Human2.60831074
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.58689491
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29374723
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27396883
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11756256
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02969626
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6886104
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99408369
18* KDM2B_26808549_Chip-Seq_K562_Human1.96626383
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96037297
20* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92387634
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90232548
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89904673
23* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88811098
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77285324
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.76085454
26ZNF263_19887448_ChIP-Seq_K562_Human1.75252248
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74614282
28TCF7_22412390_ChIP-Seq_EML_Mouse1.67215191
29UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.63857140
30KDM2B_26808549_Chip-Seq_DND41_Human1.59981395
31* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58898801
32* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49541404
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48665524
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47084032
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44700008
36* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40849824
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.39760437
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.36660492
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34427593
40* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32622608
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31824588
42TP53_22127205_ChIP-Seq_IMR90_Human1.29628879
43VDR_21846776_ChIP-Seq_THP-1_Human1.29388312
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28533708
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.25376185
46CTCF_27219007_Chip-Seq_Bcells_Human1.25266911
47MYC_22102868_ChIP-Seq_BL_Human1.22208399
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19988311
49SMC4_20622854_ChIP-Seq_HELA_Human1.19443721
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16965182
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.16952520
52* RUNX1_27514584_Chip-Seq_MCF-7_Human1.16952000
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16941261
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16625816
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16600305
56* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15393572
57P68_20966046_ChIP-Seq_HELA_Human1.14364186
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13570535
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12802688
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.12439629
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11738094
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11580423
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11398254
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.10442039
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.10209005
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09142019
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06837641
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06837641
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06837641
70SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05081778
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03850554
72SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00940128
73* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00872850
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.00414108
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98930277
76* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98845778
77P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98504402
78GATA4_25053715_ChIP-Seq_YYC3_Human0.97439059
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97434816
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97291288
81GATA1_22025678_ChIP-Seq_K562_Human0.96935388
82LXR_22292898_ChIP-Seq_THP-1_Human0.96551496
83* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95837549
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95543038
85* ISL1_27105846_Chip-Seq_CPCs_Mouse0.95225352
86* RACK7_27058665_Chip-Seq_MCF-7_Human0.90848612
87* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89665676
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.89326884
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86543797
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86492261
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84754883
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84439468
93AR_21909140_ChIP-Seq_LNCAP_Human0.82928411
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82187068
95GATA6_25053715_ChIP-Seq_YYC3_Human0.81746641
96ELK3_25401928_ChIP-Seq_HUVEC_Human0.81657202
97ATF3_27146783_Chip-Seq_COLON_Human0.81453023
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80614479
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78056232
100SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77843907
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77515763
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74077618
103* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73447240
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73115693
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72856407
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72589666
107TCF3_18692474_ChIP-Seq_MESCs_Mouse0.72435737
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.71468856
109HTT_18923047_ChIP-ChIP_STHdh_Human0.70976131
110* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.70752625
111* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70269249
112* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69527289
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68838884
114* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.68275634
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68134922
116RARA_24833708_ChIP-Seq_LIVER_Mouse0.66343859
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66040225
118CREB1_26743006_Chip-Seq_LNCaP_Human0.64624843
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.64590780
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.64557203
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.64483715
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.64469239
123ESR1_20079471_ChIP-ChIP_T-47D_Human0.62217423
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.61802087
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.61531830
126* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.60188001
127AUTS2_25519132_ChIP-Seq_293T-REX_Human0.60086641
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.59873878
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.59873878
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.59031764
131* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.58995934
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.58951593
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58277749
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.58179843
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.58136013
136* RARB_24833708_ChIP-Seq_LIVER_Mouse0.57805106
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56933149
138* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.55536651
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.55420436
140SOX2_18692474_ChIP-Seq_MESCs_Mouse0.55315127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.50682554
2MP0005360_urolithiasis6.84582690
3MP0005085_abnormal_gallbladder_physiolo5.73572745
4MP0005365_abnormal_bile_salt5.48311512
5MP0008875_abnormal_xenobiotic_pharmacok4.23428056
6MP0003806_abnormal_nucleotide_metabolis3.94365722
7MP0003252_abnormal_bile_duct3.83287712
8MP0010329_abnormal_lipoprotein_level3.30042425
9MP0009840_abnormal_foam_cell2.87185736
10MP0005083_abnormal_biliary_tract2.84889178
11MP0003279_aneurysm2.77185271
12MP0003705_abnormal_hypodermis_morpholog2.66716180
13MP0003195_calcinosis2.59080383
14MP0005332_abnormal_amino_acid2.50876561
15MP0005257_abnormal_intraocular_pressure2.45778957
16MP0004858_abnormal_nervous_system2.35925083
17MP0005409_darkened_coat_color2.28977072
18MP0001666_abnormal_nutrient_absorption2.27403663
19MP0003191_abnormal_cellular_cholesterol2.14148332
20MP0004019_abnormal_vitamin_homeostasis2.01344602
21MP0000609_abnormal_liver_physiology2.00848322
22MP0010368_abnormal_lymphatic_system1.96775952
23MP0000751_myopathy1.94934544
24MP0000566_synostosis1.90817893
25MP0002138_abnormal_hepatobiliary_system1.89455413
26MP0005503_abnormal_tendon_morphology1.80049076
27MP0002118_abnormal_lipid_homeostasis1.78274496
28MP0001958_emphysema1.77679596
29MP0005076_abnormal_cell_differentiation1.70595381
30MP0003091_abnormal_cell_migration1.67975596
31MP0005319_abnormal_enzyme/_coenzyme1.67586676
32MP0003941_abnormal_skin_development1.66257367
33MP0003868_abnormal_feces_composition1.63456705
34MP0002089_abnormal_postnatal_growth/wei1.56372828
35MP0009053_abnormal_anal_canal1.48819129
36MP0005623_abnormal_meninges_morphology1.46662847
37MP0002254_reproductive_system_inflammat1.38384955
38MP0006138_congestive_heart_failure1.37671688
39MP0000678_abnormal_parathyroid_gland1.34120405
40MP0005058_abnormal_lysosome_morphology1.34085614
41MP0009697_abnormal_copulation1.27505152
42MP0005508_abnormal_skeleton_morphology1.27359635
43MP0000003_abnormal_adipose_tissue1.23974485
44MP0000598_abnormal_liver_morphology1.22747983
45MP0009643_abnormal_urine_homeostasis1.22151761
46MP0010630_abnormal_cardiac_muscle1.18405146
47MP0005584_abnormal_enzyme/coenzyme_acti1.17796016
48MP0000013_abnormal_adipose_tissue1.17685366
49* MP0001614_abnormal_blood_vessel1.15385593
50MP0002877_abnormal_melanocyte_morpholog1.14845840
51MP0005451_abnormal_body_composition1.14444583
52MP0003011_delayed_dark_adaptation1.13485438
53MP0003385_abnormal_body_wall1.13307868
54MP0002108_abnormal_muscle_morphology1.10741410
55MP0002925_abnormal_cardiovascular_devel1.09468336
56MP0010234_abnormal_vibrissa_follicle1.09276458
57MP0002933_joint_inflammation1.08148631
58MP0005647_abnormal_sex_gland1.07819174
59MP0001764_abnormal_homeostasis1.06053429
60MP0005595_abnormal_vascular_smooth1.05468091
61MP0008438_abnormal_cutaneous_collagen1.05103398
62MP0000462_abnormal_digestive_system1.04023453
63MP0000428_abnormal_craniofacial_morphol1.04010649
64MP0001299_abnormal_eye_distance/1.03765574
65MP0003186_abnormal_redox_activity1.03576140
66MP0006054_spinal_hemorrhage1.03153014
67MP0008260_abnormal_autophagy1.02248052
68MP0004084_abnormal_cardiac_muscle1.02003985
69MP0002896_abnormal_bone_mineralization0.98697873
70MP0001348_abnormal_lacrimal_gland0.98375343
71* MP0004272_abnormal_basement_membrane0.97731168
72MP0003942_abnormal_urinary_system0.97642454
73MP0000534_abnormal_ureter_morphology0.97290296
74MP0000762_abnormal_tongue_morphology0.95409104
75MP0005670_abnormal_white_adipose0.93809590
76MP0002932_abnormal_joint_morphology0.93024184
77MP0005375_adipose_tissue_phenotype0.92337414
78MP0003283_abnormal_digestive_organ0.92167860
79MP0005330_cardiomyopathy0.91147874
80MP0005167_abnormal_blood-brain_barrier0.87098111
81MP0009763_increased_sensitivity_to0.86642863
82MP0000049_abnormal_middle_ear0.86190391
83MP0000858_altered_metastatic_potential0.85201596
84MP0004087_abnormal_muscle_fiber0.85140669
85MP0001661_extended_life_span0.83804832
86MP0005023_abnormal_wound_healing0.83549582
87MP0000733_abnormal_muscle_development0.82460263
88MP0003828_pulmonary_edema0.79884996
89MP0005275_abnormal_skin_tensile0.78803736
90MP0003566_abnormal_cell_adhesion0.78432168
91MP0005248_abnormal_Harderian_gland0.77564129
92MP0002295_abnormal_pulmonary_circulatio0.77399574
93MP0002796_impaired_skin_barrier0.77346586
94MP0005220_abnormal_exocrine_pancreas0.76294872
95MP0005408_hypopigmentation0.76058873
96MP0003329_amyloid_beta_deposits0.75928847
97MP0009780_abnormal_chondrocyte_physiolo0.75642536
98MP0002060_abnormal_skin_morphology0.74799545
99MP0001915_intracranial_hemorrhage0.74290751
100MP0003935_abnormal_craniofacial_develop0.73777865
101MP0000604_amyloidosis0.73692342
102MP0000432_abnormal_head_morphology0.72530709
103MP0000266_abnormal_heart_morphology0.72264445
104MP0009672_abnormal_birth_weight0.71086624
105MP0004233_abnormal_muscle_weight0.70966477
106MP0003984_embryonic_growth_retardation0.70325743
107MP0003656_abnormal_erythrocyte_physiolo0.68784306
108MP0009384_cardiac_valve_regurgitation0.68243917
109MP0009764_decreased_sensitivity_to0.67878266
110MP0000537_abnormal_urethra_morphology0.67158646
111MP0005666_abnormal_adipose_tissue0.65497175
112MP0009642_abnormal_blood_homeostasis0.65206259
113MP0001756_abnormal_urination0.63785290
114MP0002168_other_aberrant_phenotype0.63766400
115MP0003453_abnormal_keratinocyte_physiol0.63465474
116MP0005395_other_phenotype0.63278414
117MP0005376_homeostasis/metabolism_phenot0.62077738
118MP0004130_abnormal_muscle_cell0.60973645
119MP0003115_abnormal_respiratory_system0.59455590
120MP0004264_abnormal_extraembryonic_tissu0.58532465
121MP0005636_abnormal_mineral_homeostasis0.55690765
122MP0002136_abnormal_kidney_physiology0.55562706
123MP0002971_abnormal_brown_adipose0.54959996
124MP0008469_abnormal_protein_level0.54535181
125MP0001243_abnormal_dermal_layer0.53583523
126MP0002928_abnormal_bile_duct0.53249545
127MP0005266_abnormal_metabolism0.53178705
128MP0001849_ear_inflammation0.52646564
129MP0005334_abnormal_fat_pad0.51656956
130MP0002697_abnormal_eye_size0.50712749
131MP0000639_abnormal_adrenal_gland0.50464075
132MP0009765_abnormal_xenobiotic_induced0.49995938
133MP0005084_abnormal_gallbladder_morpholo0.49694878
134MP0000579_abnormal_nail_morphology0.49230333
135MP0002128_abnormal_blood_circulation0.49016134
136MP0010352_gastrointestinal_tract_polyps0.48955022
137MP0002078_abnormal_glucose_homeostasis0.48711966
138MP0003300_gastrointestinal_ulcer0.48424577
139MP0010030_abnormal_orbit_morphology0.45950772
140MP0004185_abnormal_adipocyte_glucose0.45933892
141MP0002092_abnormal_eye_morphology0.45066502
142MP0002135_abnormal_kidney_morphology0.44697151
143MP0002282_abnormal_trachea_morphology0.44578265
144MP0000467_abnormal_esophagus_morphology0.44184385
145MP0000767_abnormal_smooth_muscle0.44043819
146MP0004197_abnormal_fetal_growth/weight/0.43648214
147MP0003119_abnormal_digestive_system0.42659579
148MP0005187_abnormal_penis_morphology0.42224835
149MP0005501_abnormal_skin_physiology0.41473951
150MP0000249_abnormal_blood_vessel0.39950566
151MP0002086_abnormal_extraembryonic_tissu0.39445791
152MP0001879_abnormal_lymphatic_vessel0.38905957
153MP0002249_abnormal_larynx_morphology0.38292882
154MP0003638_abnormal_response/metabolism_0.38007730
155MP0004883_abnormal_blood_vessel0.37916736

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.47909707
2Intrahepatic cholestasis (HP:0001406)7.00706213
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.57394728
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.57134608
5Xanthomatosis (HP:0000991)6.04104141
6Hypobetalipoproteinemia (HP:0003563)5.96244987
7Prolonged partial thromboplastin time (HP:0003645)5.69794693
8Premature rupture of membranes (HP:0001788)5.21534498
9Complement deficiency (HP:0004431)5.08441239
10Hyperlipoproteinemia (HP:0010980)4.94852353
11Hypolipoproteinemia (HP:0010981)4.62413601
12Epidermoid cyst (HP:0200040)4.31573260
13Hyperammonemia (HP:0001987)4.28749797
14Joint hemorrhage (HP:0005261)4.26536198
15Hypoalphalipoproteinemia (HP:0003233)4.19321794
16Abnormality of the common coagulation pathway (HP:0010990)4.18286735
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17507435
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11253992
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.05241976
20Hyperglycinemia (HP:0002154)4.04495003
21Abnormality of complement system (HP:0005339)3.81516023
22Abnormality of methionine metabolism (HP:0010901)3.79717666
23Ketosis (HP:0001946)3.76293229
24Abnormality of pyrimidine metabolism (HP:0004353)3.75255630
25Cerebral aneurysm (HP:0004944)3.74253245
26Hyperglycinuria (HP:0003108)3.72534881
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.70369774
28Fat malabsorption (HP:0002630)3.69393421
29Abnormality of serine family amino acid metabolism (HP:0010894)3.61707423
30Abnormality of glycine metabolism (HP:0010895)3.61707423
31Shallow orbits (HP:0000586)3.54038769
32Abnormality of the intrinsic pathway (HP:0010989)3.53619429
33Hypercholesterolemia (HP:0003124)3.45663765
34Hypoglycemic coma (HP:0001325)3.43811469
35Hepatocellular carcinoma (HP:0001402)3.28003703
36Spastic diplegia (HP:0001264)3.16164577
37Cervical subluxation (HP:0003308)3.10941413
38Aortic dissection (HP:0002647)3.10445265
39Myocardial infarction (HP:0001658)3.09544864
40Arterial tortuosity (HP:0005116)2.94548609
41Ulnar bowing (HP:0003031)2.92670988
42Atrophic scars (HP:0001075)2.91365256
43Conjugated hyperbilirubinemia (HP:0002908)2.90214904
44Esophageal varix (HP:0002040)2.88151809
45Broad metatarsal (HP:0001783)2.85715431
46Skin nodule (HP:0200036)2.85421770
47Abnormality of nucleobase metabolism (HP:0010932)2.84863387
48Hyperbilirubinemia (HP:0002904)2.83418239
49Vascular tortuosity (HP:0004948)2.82280593
50Delayed CNS myelination (HP:0002188)2.80778424
51Abnormality of fatty-acid metabolism (HP:0004359)2.80551767
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.77692465
53Spontaneous abortion (HP:0005268)2.76550206
54Fragile skin (HP:0001030)2.73063539
55Mitral valve prolapse (HP:0001634)2.72330923
56Spinal rigidity (HP:0003306)2.72204766
57Hypochromic microcytic anemia (HP:0004840)2.70840777
58Vascular calcification (HP:0004934)2.69726620
59Ankle contracture (HP:0006466)2.67227003
60Increased connective tissue (HP:0009025)2.66595621
61Steatorrhea (HP:0002570)2.66241173
62Blue sclerae (HP:0000592)2.64832832
63Abnormality of serum amino acid levels (HP:0003112)2.59202115
64Cardiovascular calcification (HP:0011915)2.56078348
65Disproportionate tall stature (HP:0001519)2.55585428
66Aortic aneurysm (HP:0004942)2.55181598
67Ketoacidosis (HP:0001993)2.54426525
68Biconcave vertebral bodies (HP:0004586)2.54266914
69Bronchomalacia (HP:0002780)2.53289494
70Bladder diverticulum (HP:0000015)2.51763214
71Malnutrition (HP:0004395)2.44276616
72Hemorrhage of the eye (HP:0011885)2.41447071
73Abnormality of purine metabolism (HP:0004352)2.39667265
74Neonatal short-limb short stature (HP:0008921)2.38401102
75Abnormality of dentin (HP:0010299)2.36055439
76Wormian bones (HP:0002645)2.35102939
77Glomerulonephritis (HP:0000099)2.34666273
78Aneurysm (HP:0002617)2.34510142
79Broad face (HP:0000283)2.33846779
80Neonatal onset (HP:0003623)2.33295281
81Wrist flexion contracture (HP:0001239)2.33159596
82Soft skin (HP:0000977)2.32360509
83Gout (HP:0001997)2.32073825
84Systemic lupus erythematosus (HP:0002725)2.31197716
85Mitral stenosis (HP:0001718)2.28527223
86Vertebral compression fractures (HP:0002953)2.28399601
87Increased variability in muscle fiber diameter (HP:0003557)2.28341854
88Pseudobulbar signs (HP:0002200)2.27560564
89Mildly elevated creatine phosphokinase (HP:0008180)2.26156624
90Back pain (HP:0003418)2.24622429
91Flat acetabular roof (HP:0003180)2.21002128
92Cholelithiasis (HP:0001081)2.20646374
93Nonimmune hydrops fetalis (HP:0001790)2.19996773
94Abnormal gallbladder morphology (HP:0012437)2.19239820
95Nephritis (HP:0000123)2.17059551
96Hyperacusis (HP:0010780)2.15694774
97Metabolic acidosis (HP:0001942)2.15640828
98Acanthocytosis (HP:0001927)2.10649955
99Distal upper limb amyotrophy (HP:0007149)2.10598943
100Upper limb amyotrophy (HP:0009129)2.10598943
101Hypoglycemic seizures (HP:0002173)2.10567345
102Enlarged kidneys (HP:0000105)2.09483358
103Distal lower limb amyotrophy (HP:0008944)2.09089647
104Asymmetry of the thorax (HP:0001555)2.09060084
105Obstructive sleep apnea (HP:0002870)2.06665927
106Abnormal cartilage morphology (HP:0002763)2.05283835
107Focal segmental glomerulosclerosis (HP:0000097)2.05124736
108Dilatation of the ascending aorta (HP:0005111)2.04158577
109Amyloidosis (HP:0011034)2.04153951
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03783386
111Dicarboxylic aciduria (HP:0003215)2.03783386
112Lethargy (HP:0001254)2.03694441
113Hydroxyprolinuria (HP:0003080)2.03526616
114Abnormality of proline metabolism (HP:0010907)2.03526616
115Genu recurvatum (HP:0002816)2.02535834
116Late onset (HP:0003584)2.02118167
117Irritability (HP:0000737)2.00618336
118Joint laxity (HP:0001388)2.00030921
119Aplasia involving bones of the extremities (HP:0009825)1.99352604
120Aplasia involving bones of the upper limbs (HP:0009823)1.99352604
121Aplasia of the phalanges of the hand (HP:0009802)1.99352604
122Cholecystitis (HP:0001082)1.98323093
123Abnormal gallbladder physiology (HP:0012438)1.98323093
124Turricephaly (HP:0000262)1.97833451
125Glomerulosclerosis (HP:0000096)1.97753058
126Thrombophlebitis (HP:0004418)1.97253340
127Achilles tendon contracture (HP:0001771)1.96933193
128Metaphyseal cupping (HP:0003021)1.96796436
129Thin ribs (HP:0000883)1.96374994
130Abnormal delivery (HP:0001787)1.95411413
131Coxa vara (HP:0002812)1.95308755
132Type 1 muscle fiber predominance (HP:0003803)1.94892462
133Protrusio acetabuli (HP:0003179)1.93681061
134Stroke (HP:0001297)1.93136551
135Mitral regurgitation (HP:0001653)1.92311300
136Abnormality of the acetabulum (HP:0003170)1.91523149
137Abnormality of the Achilles tendon (HP:0005109)1.91033749
138Premature skin wrinkling (HP:0100678)1.90357258
139Menorrhagia (HP:0000132)1.89630475
140Abnormality of skeletal muscle fiber size (HP:0012084)1.89218764
141Rickets (HP:0002748)1.88879320
142Neonatal death (HP:0003811)1.88458186
143Hyperextensible skin (HP:0000974)1.88384164
144Abnormality of iron homeostasis (HP:0011031)1.88345099
145Hemangiomatosis (HP:0007461)1.88199082
146Distal lower limb muscle weakness (HP:0009053)1.87533783
147Abnormality of transition element cation homeostasis (HP:0011030)1.87458991
148Coronal craniosynostosis (HP:0004440)1.85922354
149Abnormal vertebral ossification (HP:0100569)1.85870371
150Thin bony cortex (HP:0002753)1.84997785
151Arnold-Chiari malformation (HP:0002308)1.84085951
152Gingival bleeding (HP:0000225)1.83374275
153Increased mean platelet volume (HP:0011877)1.83194826
154Reticulocytosis (HP:0001923)1.81630323
155Abnormal enzyme/coenzyme activity (HP:0012379)1.80743386
156Sensorimotor neuropathy (HP:0007141)1.78848583
157Visceral angiomatosis (HP:0100761)1.78538953
158Stridor (HP:0010307)1.78082669
159Abnormality of the gallbladder (HP:0005264)1.75651460
160Wide anterior fontanel (HP:0000260)1.75593441
161Pancreatitis (HP:0001733)1.73857964
162J-shaped sella turcica (HP:0002680)1.73090203
163Vertebral clefting (HP:0008428)1.73024296
164Advanced eruption of teeth (HP:0006288)1.72740909
165* Ectopia lentis (HP:0001083)1.72517326
166Difficulty climbing stairs (HP:0003551)1.70607779
167Joint stiffness (HP:0001387)1.68368931
168Bowing of the arm (HP:0006488)1.68148711
169Bowed forearm bones (HP:0003956)1.68148711
170Neoplasm of the liver (HP:0002896)1.67574890
171Venous insufficiency (HP:0005293)1.67334527
172Selective tooth agenesis (HP:0001592)1.66647851
173Choanal stenosis (HP:0000452)1.66579960
174Polycythemia (HP:0001901)1.66198273
175Venous abnormality (HP:0002624)1.65709618
176Right ventricular cardiomyopathy (HP:0011663)1.65410007
177Peritonitis (HP:0002586)1.65043248
178Brushfield spots (HP:0001088)1.64849983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.56729879
2SIK13.82191494
3ERN13.73368520
4FGFR43.52781160
5PKN23.37062496
6LATS13.12680021
7TRIB33.08996841
8SMG12.94482699
9EPHA22.86285611
10PTK62.39446713
11ERBB42.22116497
12TIE12.19780167
13MAP3K102.17718354
14NTRK12.15041163
15RIPK11.99616399
16FLT31.87836236
17KDR1.74744054
18CDK121.69724059
19PDGFRA1.63794820
20EPHB21.55191028
21MET1.52873609
22STK38L1.52800969
23PTK21.51405563
24TTN1.41863916
25MST1R1.36452958
26PAK41.35390025
27CDC42BPA1.31042514
28PRPF4B1.30200434
29LATS21.28460837
30ICK1.25830378
31CDK61.24415663
32TGFBR21.22766331
33FGFR21.18848510
34RPS6KA21.18189323
35MAPK111.18079782
36INSRR1.17667965
37MTOR1.17255075
38EPHB11.15750743
39FER1.14327197
40ERBB21.12748947
41NEK91.11367003
42CAMK1D1.11126943
43MAP3K61.09510931
44LMTK21.08087345
45MAP3K31.04718329
46MAP2K41.03173738
47BMX1.02780467
48TESK11.01254324
49PRKD21.00416075
50PAK20.99970244
51MAP2K30.97074635
52FGFR10.94925136
53MARK20.94542279
54DYRK1B0.94358555
55STK30.91174333
56TAOK30.88879323
57CDK40.88380403
58MAP3K70.86722195
59TGFBR10.85824368
60ABL20.84518869
61DMPK0.83959185
62GSK3A0.82450782
63IRAK30.77985063
64TYK20.77823579
65PIK3CG0.75310798
66RPS6KL10.72331965
67RPS6KC10.72331965
68DDR20.71544929
69NEK10.70934380
70PRKAA20.69270493
71RPS6KB20.68066245
72EEF2K0.67445341
73FRK0.66489802
74PDPK10.65461427
75MAP2K20.64685508
76JAK20.64311286
77STK380.63430964
78LRRK20.62491714
79ILK0.59271313
80MAP3K10.57941469
81DAPK20.57478046
82CAMK1G0.57066864
83MAP3K110.55373730
84ROCK20.55289079
85MAP2K10.54449750
86TYRO30.54161542
87MAP3K80.54002514
88MYLK0.53967409
89KSR20.53745422
90FGFR30.53077499
91MAPK150.52346751
92PRKD30.51622946
93RET0.51590373
94ROCK10.51561638
95RPS6KA60.49115180
96CSK0.48078782
97HIPK20.48077240
98EPHA30.47841854
99MAPKAPK30.45678056
100TRPM70.45197509
101PRKD10.43211275
102STK100.43000680
103ZAP700.42453598
104PTK2B0.41823877
105PRKCZ0.41545807
106CDK70.41126461
107EGFR0.40928215
108SRC0.40573466
109MAP3K130.39629948
110CHUK0.38730781
111PAK30.38267940
112CDK90.38212754
113PRKACG0.37705506
114GRK60.37618084
115TTK0.36632821
116AKT20.36469972
117PRKAA10.36306018
118TAOK20.36216270
119CSNK1G10.36189255
120MAPK40.34014266
121TBK10.31009656
122PDGFRB0.30930941
123IGF1R0.30120095
124PRKG20.29335391
125JAK10.28842589
126LIMK10.28506336
127DAPK30.27934927
128MAP3K20.27243659
129MAPK10.27020023
130MAPK70.27018726
131MAPKAPK20.26751357
132NEK20.26577548
133JAK30.25409362
134MAPK120.24722584
135CSNK1A1L0.23864581
136INSR0.23423850
137ARAF0.23235988
138CSNK1E0.22931314
139RPS6KA10.22301175
140MAPK100.20335490
141SGK30.19521777

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.35173531
2Nitrogen metabolism_Homo sapiens_hsa009103.82123828
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39001015
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35344907
5Arginine biosynthesis_Homo sapiens_hsa002203.15927827
6Complement and coagulation cascades_Homo sapiens_hsa046102.86041793
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65480235
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60648249
9Tryptophan metabolism_Homo sapiens_hsa003802.60410269
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58058886
11Fatty acid degradation_Homo sapiens_hsa000712.52741412
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31296875
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13730845
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97371883
15PPAR signaling pathway_Homo sapiens_hsa033201.96467094
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.96306011
17Butanoate metabolism_Homo sapiens_hsa006501.94859570
18Peroxisome_Homo sapiens_hsa041461.88293532
19Fatty acid metabolism_Homo sapiens_hsa012121.87435354
20Other glycan degradation_Homo sapiens_hsa005111.86937675
21Propanoate metabolism_Homo sapiens_hsa006401.84864473
22Chemical carcinogenesis_Homo sapiens_hsa052041.83231643
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.81846228
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80703947
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77248838
26Histidine metabolism_Homo sapiens_hsa003401.75185271
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.75005138
28Selenocompound metabolism_Homo sapiens_hsa004501.74018528
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72209794
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.67692127
31beta-Alanine metabolism_Homo sapiens_hsa004101.63596932
32Staphylococcus aureus infection_Homo sapiens_hsa051501.63511686
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61390956
34Retinol metabolism_Homo sapiens_hsa008301.60689786
35Phenylalanine metabolism_Homo sapiens_hsa003601.55201537
36Bile secretion_Homo sapiens_hsa049761.54926924
37Caffeine metabolism_Homo sapiens_hsa002321.53733423
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49841370
39Tyrosine metabolism_Homo sapiens_hsa003501.39752854
40Pyruvate metabolism_Homo sapiens_hsa006201.37709529
41Biosynthesis of amino acids_Homo sapiens_hsa012301.37147546
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.33348752
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25804647
44Chronic myeloid leukemia_Homo sapiens_hsa052201.25042384
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24174181
46Carbon metabolism_Homo sapiens_hsa012001.22873885
47Fat digestion and absorption_Homo sapiens_hsa049751.21299433
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20569327
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.19837250
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19826751
51Starch and sucrose metabolism_Homo sapiens_hsa005001.19672982
52Dilated cardiomyopathy_Homo sapiens_hsa054141.17026059
53Thyroid cancer_Homo sapiens_hsa052161.14660725
54Lysine degradation_Homo sapiens_hsa003101.12333476
55Tight junction_Homo sapiens_hsa045301.11964944
56One carbon pool by folate_Homo sapiens_hsa006701.11472740
57Fatty acid elongation_Homo sapiens_hsa000621.08115082
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07687435
59ABC transporters_Homo sapiens_hsa020101.07078206
60Sulfur metabolism_Homo sapiens_hsa009201.06617118
61Folate biosynthesis_Homo sapiens_hsa007901.05262530
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.03205394
63Steroid biosynthesis_Homo sapiens_hsa001000.99415244
64Arginine and proline metabolism_Homo sapiens_hsa003300.96426954
65MicroRNAs in cancer_Homo sapiens_hsa052060.96332159
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95169123
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94573191
68VEGF signaling pathway_Homo sapiens_hsa043700.93340927
69Axon guidance_Homo sapiens_hsa043600.91487149
70Vitamin digestion and absorption_Homo sapiens_hsa049770.89109062
71Endometrial cancer_Homo sapiens_hsa052130.88818322
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87509282
73Sulfur relay system_Homo sapiens_hsa041220.86556698
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.85642256
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85522254
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83955140
77Acute myeloid leukemia_Homo sapiens_hsa052210.79355606
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76848650
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.75645993
80Rap1 signaling pathway_Homo sapiens_hsa040150.75334782
81Glioma_Homo sapiens_hsa052140.75039864
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71563652
83Pancreatic cancer_Homo sapiens_hsa052120.71138896
84Pathways in cancer_Homo sapiens_hsa052000.70806027
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70549815
86Melanogenesis_Homo sapiens_hsa049160.69847969
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69154810
88Vitamin B6 metabolism_Homo sapiens_hsa007500.68351373
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67581668
90Renal cell carcinoma_Homo sapiens_hsa052110.67509964
91Prostate cancer_Homo sapiens_hsa052150.67150118
92Fatty acid biosynthesis_Homo sapiens_hsa000610.66980100
93Glycerolipid metabolism_Homo sapiens_hsa005610.65021281
94Glutathione metabolism_Homo sapiens_hsa004800.63032675
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62973069
96Choline metabolism in cancer_Homo sapiens_hsa052310.58296460
97Non-small cell lung cancer_Homo sapiens_hsa052230.58259505
98Wnt signaling pathway_Homo sapiens_hsa043100.57637517
99Pentose phosphate pathway_Homo sapiens_hsa000300.56326267
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54916785
101Estrogen signaling pathway_Homo sapiens_hsa049150.54566793
102ErbB signaling pathway_Homo sapiens_hsa040120.54548040
103Hedgehog signaling pathway_Homo sapiens_hsa043400.51897179
104Thyroid hormone synthesis_Homo sapiens_hsa049180.50196894
105Insulin resistance_Homo sapiens_hsa049310.39476848
106ECM-receptor interaction_Homo sapiens_hsa045120.39245959
107Prion diseases_Homo sapiens_hsa050200.39238354
108Metabolic pathways_Homo sapiens_hsa011000.32999266
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.31869291
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29395196
111Galactose metabolism_Homo sapiens_hsa000520.24846102
112Amoebiasis_Homo sapiens_hsa051460.19575848
113Fructose and mannose metabolism_Homo sapiens_hsa000510.18761074
114Bladder cancer_Homo sapiens_hsa052190.18126476
115AMPK signaling pathway_Homo sapiens_hsa041520.17737542
116Glucagon signaling pathway_Homo sapiens_hsa049220.16318678
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14025356
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.13175148
119Small cell lung cancer_Homo sapiens_hsa052220.13128911
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10910232
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09154807
122Basal cell carcinoma_Homo sapiens_hsa052170.07496854
123Focal adhesion_Homo sapiens_hsa045100.06273537
124Linoleic acid metabolism_Homo sapiens_hsa005910.04205391
125Adherens junction_Homo sapiens_hsa045200.03569173
126* Protein digestion and absorption_Homo sapiens_hsa049740.02644965
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.00398111
128Systemic lupus erythematosus_Homo sapiens_hsa053220.00075303
129Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0969674
130PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0938938
131Renin-angiotensin system_Homo sapiens_hsa04614-0.0881319
132Notch signaling pathway_Homo sapiens_hsa04330-0.0549112
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0460752
134Hippo signaling pathway_Homo sapiens_hsa04390-0.0412952
135TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0409584
136Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0195883
137Proteoglycans in cancer_Homo sapiens_hsa05205-0.0189600
138Insulin signaling pathway_Homo sapiens_hsa04910-0.0114636

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