COL20A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)8.61619401
2dermatan sulfate biosynthetic process (GO:0030208)7.45171234
3locomotory exploration behavior (GO:0035641)7.05240492
4dermatan sulfate metabolic process (GO:0030205)7.01215260
5neuron cell-cell adhesion (GO:0007158)7.00964669
6sperm motility (GO:0030317)6.97561427
7presynaptic membrane assembly (GO:0097105)6.61595028
8fusion of sperm to egg plasma membrane (GO:0007342)6.54482043
9central nervous system myelination (GO:0022010)6.35068898
10axon ensheathment in central nervous system (GO:0032291)6.35068898
11acrosome reaction (GO:0007340)6.09458078
12photoreceptor cell differentiation (GO:0046530)6.06179902
13eye photoreceptor cell differentiation (GO:0001754)6.06179902
14chondroitin sulfate catabolic process (GO:0030207)6.05589466
15presynaptic membrane organization (GO:0097090)5.93104506
16cell wall macromolecule catabolic process (GO:0016998)5.82150661
17cell wall macromolecule metabolic process (GO:0044036)5.82150661
18sperm-egg recognition (GO:0035036)5.34927300
19positive regulation of oligodendrocyte differentiation (GO:0048714)5.28411168
20L-amino acid import (GO:0043092)5.27970920
21acrosome assembly (GO:0001675)5.27091531
22multicellular organism reproduction (GO:0032504)5.14244680
23astrocyte differentiation (GO:0048708)5.12566833
24oligodendrocyte differentiation (GO:0048709)5.08022454
25nephron tubule formation (GO:0072079)5.02405916
26plasma membrane fusion (GO:0045026)5.01926953
27exploration behavior (GO:0035640)4.98991298
28cell-cell recognition (GO:0009988)4.97653368
29ionotropic glutamate receptor signaling pathway (GO:0035235)4.92993873
30positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.89957517
31spermatid development (GO:0007286)4.85931024
32amino acid import (GO:0043090)4.81301143
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.71854595
34positive regulation of osteoblast proliferation (GO:0033690)4.64522157
35enteric nervous system development (GO:0048484)4.63583078
36binding of sperm to zona pellucida (GO:0007339)4.52210565
37cilium or flagellum-dependent cell motility (GO:0001539)4.50630133
38negative regulation of inclusion body assembly (GO:0090084)4.46744813
39reproduction (GO:0000003)4.46688155
40mechanosensory behavior (GO:0007638)4.28552545
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24982887
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.22626012
43neurotransmitter-gated ion channel clustering (GO:0072578)4.18314347
44regulation of synapse structural plasticity (GO:0051823)4.18216024
45positive regulation of gliogenesis (GO:0014015)4.13458182
46vocalization behavior (GO:0071625)4.12756155
47potassium ion import (GO:0010107)4.10103758
48regulation of neurotransmitter uptake (GO:0051580)4.07443008
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.05873731
50organic cation transport (GO:0015695)4.02832084
51synaptic transmission, glutamatergic (GO:0035249)4.00127748
52epithelial cilium movement (GO:0003351)3.99471333
53sperm capacitation (GO:0048240)3.96818119
54synaptic vesicle maturation (GO:0016188)3.87463350
55protein localization to synapse (GO:0035418)3.84513478
56cellular potassium ion homeostasis (GO:0030007)3.80382350
57regulation of axon regeneration (GO:0048679)3.77990708
58regulation of neuron projection regeneration (GO:0070570)3.77990708
59auditory behavior (GO:0031223)3.77841893
60axonemal dynein complex assembly (GO:0070286)3.75313473
61regulation of cilium movement (GO:0003352)3.73737465
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72387197
63neurotransmitter uptake (GO:0001504)3.69539508
64potassium ion homeostasis (GO:0055075)3.67993850
65positive regulation of neurological system process (GO:0031646)3.64657144
66astrocyte development (GO:0014002)3.60531654
67positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.60173408
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.57578848
69regulation of glutamate receptor signaling pathway (GO:1900449)3.56373564
70glial cell differentiation (GO:0010001)3.55072574
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.53104413
72Sertoli cell development (GO:0060009)3.52770090
73regulation of respiratory system process (GO:0044065)3.47851940
74macroautophagy (GO:0016236)3.46166504
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.43957027
76transmission of nerve impulse (GO:0019226)3.43079583
77membrane assembly (GO:0071709)3.39219750
78regulation of oligodendrocyte differentiation (GO:0048713)3.36840783
79thalamus development (GO:0021794)3.36076444
80sodium ion export (GO:0071436)3.35871775
81glutamate receptor signaling pathway (GO:0007215)3.35710781
82chondroitin sulfate biosynthetic process (GO:0030206)3.32991414
83motile cilium assembly (GO:0044458)3.32608155
84acidic amino acid transport (GO:0015800)3.30650596
85regulation of transmission of nerve impulse (GO:0051969)3.27490644
86protein carboxylation (GO:0018214)3.27029214
87peptidyl-glutamic acid carboxylation (GO:0017187)3.27029214
88myelination (GO:0042552)3.26752755
89negative regulation of axonogenesis (GO:0050771)3.22622439
90single fertilization (GO:0007338)3.22206974
91neuron projection regeneration (GO:0031102)3.21746868
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.21307186
93negative regulation of neurotransmitter transport (GO:0051589)3.20411655
94complement activation, alternative pathway (GO:0006957)3.19209521
95neuronal ion channel clustering (GO:0045161)3.19063162
96ensheathment of neurons (GO:0007272)3.17929251
97axon ensheathment (GO:0008366)3.17929251
98negative regulation of myoblast differentiation (GO:0045662)3.17868508
99retrograde transport, vesicle recycling within Golgi (GO:0000301)3.16550563
100regulation of gliogenesis (GO:0014013)3.16144966
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15599974
102regulation of cholesterol homeostasis (GO:2000188)3.14792617
103negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13308981
104regulation of neuronal synaptic plasticity (GO:0048168)3.13200679
105cerebellar granule cell differentiation (GO:0021707)3.12885007
106protein targeting to Golgi (GO:0000042)3.10355640
107L-phenylalanine catabolic process (GO:0006559)3.08865015
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.08865015
109synaptonemal complex organization (GO:0070193)3.08827225
110peripheral nervous system development (GO:0007422)3.05079119
111establishment of protein localization to Golgi (GO:0072600)3.04667054
112synaptonemal complex assembly (GO:0007130)3.03719932
113cilium movement (GO:0003341)3.03465522
114negative regulation of synaptic transmission (GO:0050805)3.03344462
115spermatogenesis (GO:0007283)3.02281441
116lipid translocation (GO:0034204)3.02240657
117phospholipid translocation (GO:0045332)3.02240657
118negative regulation of axon extension (GO:0030517)3.01887176
119neuron recognition (GO:0008038)3.01748018
120alpha-linolenic acid metabolic process (GO:0036109)3.01340155
121membrane hyperpolarization (GO:0060081)3.00342990
122male gamete generation (GO:0048232)3.00241175
123carnitine transmembrane transport (GO:1902603)2.98957750
124neuron-neuron synaptic transmission (GO:0007270)2.98529977
125response to auditory stimulus (GO:0010996)2.97256584
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.96752602
127regulation of female receptivity (GO:0045924)2.95645712
128long-term synaptic potentiation (GO:0060291)2.95397970
129regulation of synaptic vesicle exocytosis (GO:2000300)2.95225804
130amino-acid betaine transport (GO:0015838)2.95220969
131carnitine transport (GO:0015879)2.95220969
132positive regulation of glial cell differentiation (GO:0045687)2.93203537
133negative regulation of neurotransmitter secretion (GO:0046929)2.92972700
134gamma-aminobutyric acid transport (GO:0015812)2.92434527
135regulation of short-term neuronal synaptic plasticity (GO:0048172)2.92119056
136dendritic spine morphogenesis (GO:0060997)2.91957954
137developmental induction (GO:0031128)2.91026279
138regulation of protein activation cascade (GO:2000257)2.86246463
139L-glutamate transport (GO:0015813)2.86037390
140neuron fate commitment (GO:0048663)2.85099909
141cerebellar Purkinje cell layer development (GO:0021680)2.85049522
142male meiosis (GO:0007140)2.84904941
143positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.84829277
144one-carbon compound transport (GO:0019755)2.84393984
145urea cycle (GO:0000050)2.83860518
146urea metabolic process (GO:0019627)2.83860518
147fertilization (GO:0009566)2.83581416
148regulation of inclusion body assembly (GO:0090083)2.80991636
149cell-cell signaling involved in cell fate commitment (GO:0045168)2.78503083
150regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78319220
151growth hormone receptor signaling pathway (GO:0060396)2.78217604
152positive regulation of glycolytic process (GO:0045821)2.77213011
153positive regulation of membrane potential (GO:0045838)2.76729804
154neuromuscular process controlling balance (GO:0050885)2.76301254
155positive regulation of histone deacetylation (GO:0031065)2.74550040
156regulation of complement activation (GO:0030449)2.71316861
157gamete generation (GO:0007276)2.70215474
158peptidyl-glutamic acid modification (GO:0018200)2.69322818
159erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.68979184
160L-phenylalanine metabolic process (GO:0006558)2.68979184
161mannose metabolic process (GO:0006013)2.68637763
162calcium ion-dependent exocytosis (GO:0017156)2.57325594
163regulation of protein polyubiquitination (GO:1902914)2.55026866
164hemidesmosome assembly (GO:0031581)2.55010563
165triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.53013831
166cellular process involved in reproduction in multicellular organism (GO:0022412)2.52514841
167lactate metabolic process (GO:0006089)2.50197773
168piRNA metabolic process (GO:0034587)2.49616117
169antigen processing and presentation via MHC class Ib (GO:0002475)2.48463911
170ventricular system development (GO:0021591)2.48270430
171germ cell development (GO:0007281)2.48165224
172cellular response to growth hormone stimulus (GO:0071378)2.46698388
173plasma lipoprotein particle clearance (GO:0034381)2.42160784
174cell recognition (GO:0008037)2.41445691
175regulation of triglyceride catabolic process (GO:0010896)2.41227204
176nitrogen cycle metabolic process (GO:0071941)2.38360162
177homocysteine metabolic process (GO:0050667)2.37840376
178regulation of bile acid biosynthetic process (GO:0070857)2.37288535
179sulfur amino acid catabolic process (GO:0000098)2.33083466
180creatine metabolic process (GO:0006600)2.30650878
181positive regulation of catenin import into nucleus (GO:0035413)2.29775400
182genitalia morphogenesis (GO:0035112)2.28909713
183positive regulation of p38MAPK cascade (GO:1900745)2.27969566
184regulation of fatty acid beta-oxidation (GO:0031998)2.26423645
185negative regulation of protein activation cascade (GO:2000258)2.26108072
186seminiferous tubule development (GO:0072520)2.25611289
187complement activation, classical pathway (GO:0006958)2.25185029
188aromatic amino acid family catabolic process (GO:0009074)2.23515660
189high-density lipoprotein particle remodeling (GO:0034375)2.21472474
190low-density lipoprotein particle clearance (GO:0034383)2.19935450
191positive regulation of lipoprotein lipase activity (GO:0051006)2.16550304
192positive regulation of triglyceride lipase activity (GO:0061365)2.16550304
193multicellular organismal reproductive process (GO:0048609)2.14359959
194complement activation (GO:0006956)2.12045772
195heparin biosynthetic process (GO:0030210)2.11947261
196heparin metabolic process (GO:0030202)2.11947261
197protein-lipid complex assembly (GO:0065005)2.11297023
198cysteine metabolic process (GO:0006534)2.10340626
199sexual reproduction (GO:0019953)2.10240316
200regulation of p38MAPK cascade (GO:1900744)2.09576523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.05718770
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.04951897
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96380659
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.89077020
5GBX2_23144817_ChIP-Seq_PC3_Human2.81668756
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78385204
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.68421030
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67083748
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63600654
10RNF2_27304074_Chip-Seq_ESCs_Mouse2.58809629
11REST_21632747_ChIP-Seq_MESCs_Mouse2.58394591
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.56316424
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54235875
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52250483
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52250483
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.50949101
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.44222459
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37172423
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.37114041
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36398302
21EZH2_22144423_ChIP-Seq_EOC_Human2.33525022
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.31696622
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30289353
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27160797
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14744644
26AR_21572438_ChIP-Seq_LNCaP_Human2.13469933
27PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03361645
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02492087
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00896189
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.97440503
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.95684891
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.83659586
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83585878
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80597670
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.76043433
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72549613
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.72229929
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.61029061
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60467337
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58839756
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58193589
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52027577
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49765768
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47842369
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.36544320
46DROSHA_22980978_ChIP-Seq_HELA_Human1.34393260
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33385649
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33187580
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29567479
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28608053
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27713770
52PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.27644390
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26519280
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23316067
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22553835
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21358162
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19229906
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18429070
59* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17171477
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16472232
61ZNF274_21170338_ChIP-Seq_K562_Hela1.16316534
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15473062
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14275079
64TBX20_22080862_ChIP-Seq_HEART_Mouse1.13950289
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.13950289
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13861741
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.13672080
68VDR_24787735_ChIP-Seq_THP-1_Human1.12537688
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11559877
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11116534
71RUNX_20019798_ChIP-Seq_JUKART_Human1.11008912
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10856207
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10510772
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08919688
75TCF7_22412390_ChIP-Seq_EML_Mouse1.08695961
76* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08209388
77GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.07792867
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07760324
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07032325
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06476456
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.04529362
82KDM2B_26808549_Chip-Seq_DND41_Human1.02519449
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.02211028
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02210407
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01875744
86AR_19668381_ChIP-Seq_PC3_Human1.01595611
87AHR_22903824_ChIP-Seq_MCF-7_Human1.00765947
88SMAD3_21741376_ChIP-Seq_ESCs_Human1.00711464
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.00494523
90* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00398865
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00089306
92MYC_27129775_Chip-Seq_CORNEA_Mouse1.00033465
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.99864857
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98705010
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98434426
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.98425119
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96904934
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96256947
99LXR_22292898_ChIP-Seq_THP-1_Human0.96012040
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.95741257
101SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95736286
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95012986
103EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94870164
104SMAD4_21799915_ChIP-Seq_A2780_Human0.94433003
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.92374928
106TP53_23651856_ChIP-Seq_MEFs_Mouse0.92280807
107* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91879438
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91856247
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91538888
110STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91158911
111ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90746846
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90310666
113FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89783016
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89056702
115GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88991088
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88439237
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88315578
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87950452
119POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87475147
120CJUN_26792858_Chip-Seq_BT549_Human0.87269903
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87130307
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87110794
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86843657
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86677155
125KDM2B_26808549_Chip-Seq_K562_Human0.86508005
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.86199131
127GF1_26923725_Chip-Seq_HPCs_Mouse0.86139212
128NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.85548424
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85404719
130SCL_19346495_ChIP-Seq_HPC-7_Human0.85263117
131KLF4_19829295_ChIP-Seq_ESCs_Human0.84985081
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84729190
133RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84532460
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83709957
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83709957
136LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.83086850
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82486788
138FLI1_21867929_ChIP-Seq_TH2_Mouse0.82130000
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81973947
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.81830980
141IRF8_22096565_ChIP-ChIP_GC-B_Human0.81583785
142ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81400683
143SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81389759
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80784771
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80043033
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.80011244
147GATA1_19941826_ChIP-Seq_K562_Human0.79233520
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79115530
149STAT3_23295773_ChIP-Seq_U87_Human0.78720268
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77490883
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.76629930
152TCF4_23295773_ChIP-Seq_U87_Human0.76329532
153SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76213960
154AR_25329375_ChIP-Seq_VCAP_Human0.75907643
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75789684
156* OCT4_19829295_ChIP-Seq_ESCs_Human0.75773588
157TP63_22573176_ChIP-Seq_HFKS_Human0.75548919
158FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75223205
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74818879
160KDM2B_26808549_Chip-Seq_REH_Human0.74418725
161EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73770976
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73730832
163MTF2_20144788_ChIP-Seq_MESCs_Mouse0.73380530
164CTCF_27219007_Chip-Seq_Bcells_Human0.73375532
165* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73331522
166VDR_24763502_ChIP-Seq_THP-1_Human0.73284398
167CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.73275988
168IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.73180323
169CBP_20019798_ChIP-Seq_JUKART_Human0.73180323
170SMAD3_21741376_ChIP-Seq_HESCs_Human0.73118466
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.73038227
172EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.72920066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.87912904
2MP0004859_abnormal_synaptic_plasticity4.16292714
3MP0005423_abnormal_somatic_nervous3.56313848
4MP0002736_abnormal_nociception_after3.51162533
5MP0004885_abnormal_endolymph3.41363998
6MP0002139_abnormal_hepatobiliary_system3.32281996
7MP0003136_yellow_coat_color3.27415669
8MP0003635_abnormal_synaptic_transmissio3.14923575
9MP0001968_abnormal_touch/_nociception3.12126728
10MP0001486_abnormal_startle_reflex3.11556218
11MP0003880_abnormal_central_pattern3.06788322
12MP0005360_urolithiasis3.01544671
13MP0005365_abnormal_bile_salt2.91348170
14MP0003045_fibrosis2.85775826
15MP0000569_abnormal_digit_pigmentation2.73025189
16MP0002064_seizures2.65219012
17MP0003252_abnormal_bile_duct2.64124680
18MP0004270_analgesia2.62579479
19MP0001502_abnormal_circadian_rhythm2.56379724
20MP0005167_abnormal_blood-brain_barrier2.51661879
21MP0001984_abnormal_olfaction2.50087982
22MP0002063_abnormal_learning/memory/cond2.49794395
23MP0000778_abnormal_nervous_system2.45947328
24MP0002272_abnormal_nervous_system2.43530615
25MP0005646_abnormal_pituitary_gland2.37292348
26MP0008875_abnormal_xenobiotic_pharmacok2.36988423
27MP0005670_abnormal_white_adipose2.35581600
28MP0004272_abnormal_basement_membrane2.34806073
29MP0003011_delayed_dark_adaptation2.33893512
30MP0003698_abnormal_male_reproductive2.33866509
31MP0002734_abnormal_mechanical_nocicepti2.31838299
32MP0009745_abnormal_behavioral_response2.23398450
33MP0002735_abnormal_chemical_nociception2.13935437
34MP0010329_abnormal_lipoprotein_level2.13434488
35MP0003329_amyloid_beta_deposits2.12865646
36MP0003705_abnormal_hypodermis_morpholog2.12376775
37MP0002572_abnormal_emotion/affect_behav2.11607312
38MP0002733_abnormal_thermal_nociception1.98100666
39MP0001970_abnormal_pain_threshold1.96649640
40MP0001929_abnormal_gametogenesis1.96008566
41MP0005085_abnormal_gallbladder_physiolo1.91779374
42MP0003950_abnormal_plasma_membrane1.90444881
43MP0005171_absent_coat_pigmentation1.89819107
44MP0009780_abnormal_chondrocyte_physiolo1.79825134
45MP0008438_abnormal_cutaneous_collagen1.74644468
46MP0004142_abnormal_muscle_tone1.72393508
47MP0002067_abnormal_sensory_capabilities1.67553414
48MP0002557_abnormal_social/conspecific_i1.66762027
49MP0000955_abnormal_spinal_cord1.64956828
50MP0000733_abnormal_muscle_development1.63658626
51MP0008569_lethality_at_weaning1.63287044
52MP0001485_abnormal_pinna_reflex1.59837109
53MP0003633_abnormal_nervous_system1.57829967
54MP0000920_abnormal_myelination1.54498492
55MP0003183_abnormal_peptide_metabolism1.51317285
56MP0002882_abnormal_neuron_morphology1.46459734
57MP0005623_abnormal_meninges_morphology1.43410625
58MP0002254_reproductive_system_inflammat1.43117691
59MP0005551_abnormal_eye_electrophysiolog1.42772051
60MP0003690_abnormal_glial_cell1.42223345
61MP0001501_abnormal_sleep_pattern1.41984819
62MP0000751_myopathy1.41636686
63MP0002837_dystrophic_cardiac_calcinosis1.41039766
64MP0003631_nervous_system_phenotype1.39004149
65MP0001986_abnormal_taste_sensitivity1.38728709
66MP0001905_abnormal_dopamine_level1.37408509
67MP0003879_abnormal_hair_cell1.37372946
68MP0004510_myositis1.37285618
69MP0002118_abnormal_lipid_homeostasis1.34829236
70MP0000609_abnormal_liver_physiology1.34272963
71MP0009840_abnormal_foam_cell1.32415822
72MP0009278_abnormal_bone_marrow1.30226667
73MP0003300_gastrointestinal_ulcer1.29841629
74MP0003195_calcinosis1.29647274
75MP0004811_abnormal_neuron_physiology1.28456077
76MP0002909_abnormal_adrenal_gland1.28311859
77MP0006276_abnormal_autonomic_nervous1.27391925
78MP0002152_abnormal_brain_morphology1.27075700
79MP0002168_other_aberrant_phenotype1.25838546
80MP0004130_abnormal_muscle_cell1.25284299
81MP0002161_abnormal_fertility/fecundity1.24647590
82MP0002638_abnormal_pupillary_reflex1.19449466
83MP0002066_abnormal_motor_capabilities/c1.18636227
84MP0001963_abnormal_hearing_physiology1.16164211
85MP0002971_abnormal_brown_adipose1.14391598
86MP0008961_abnormal_basal_metabolism1.13815145
87MP0002108_abnormal_muscle_morphology1.13780241
88MP0001440_abnormal_grooming_behavior1.13693363
89MP0000026_abnormal_inner_ear1.11918376
90MP0001324_abnormal_eye_pigmentation1.11137280
91MP0004742_abnormal_vestibular_system1.10532450
92MP0003868_abnormal_feces_composition1.10330680
93MP0000631_abnormal_neuroendocrine_gland1.10285718
94MP0009384_cardiac_valve_regurgitation1.08372341
95MP0005666_abnormal_adipose_tissue1.06969373
96MP0004264_abnormal_extraembryonic_tissu1.06335561
97MP0002166_altered_tumor_susceptibility1.01745408
98MP0002090_abnormal_vision1.00125914
99MP0001529_abnormal_vocalization0.99086382
100MP0004087_abnormal_muscle_fiber0.98563429
101MP0002877_abnormal_melanocyte_morpholog0.98480412
102MP0000579_abnormal_nail_morphology0.97216082
103MP0002269_muscular_atrophy0.96828097
104MP0005319_abnormal_enzyme/_coenzyme0.95578072
105MP0005083_abnormal_biliary_tract0.95533342
106MP0005645_abnormal_hypothalamus_physiol0.94360404
107MP0003172_abnormal_lysosome_physiology0.93204466
108MP0005253_abnormal_eye_physiology0.91017972
109MP0000685_abnormal_immune_system0.90805375
110MP0004043_abnormal_pH_regulation0.90708424
111MP0002229_neurodegeneration0.90327390
112MP0001177_atelectasis0.89574647
113MP0001765_abnormal_ion_homeostasis0.88896527
114MP0005076_abnormal_cell_differentiation0.88524423
115MP0005386_behavior/neurological_phenoty0.88089399
116MP0004924_abnormal_behavior0.88089399
117MP0001666_abnormal_nutrient_absorption0.87385786
118MP0000534_abnormal_ureter_morphology0.86967755
119MP0003861_abnormal_nervous_system0.85898491
120MP0005397_hematopoietic_system_phenotyp0.85819323
121MP0001545_abnormal_hematopoietic_system0.85819323
122MP0000462_abnormal_digestive_system0.85357236
123MP0003283_abnormal_digestive_organ0.85135252
124MP0002249_abnormal_larynx_morphology0.84825055
125MP0002752_abnormal_somatic_nervous0.84392095
126MP0002184_abnormal_innervation0.82921695
127MP0003787_abnormal_imprinting0.82764275
128MP0003632_abnormal_nervous_system0.82547035
129MP0005375_adipose_tissue_phenotype0.82229983
130MP0009046_muscle_twitch0.80117822
131MP0000747_muscle_weakness0.80083304
132MP0003119_abnormal_digestive_system0.79960695
133MP0002069_abnormal_eating/drinking_beha0.79900996
134MP0002653_abnormal_ependyma_morphology0.79803038
135MP0005334_abnormal_fat_pad0.78598426
136MP0010630_abnormal_cardiac_muscle0.78433769
137MP0005387_immune_system_phenotype0.78293324
138MP0001790_abnormal_immune_system0.78293324
139MP0002933_joint_inflammation0.77688850
140MP0005647_abnormal_sex_gland0.76963138
141MP0005275_abnormal_skin_tensile0.76850666
142MP0000604_amyloidosis0.76670797
143MP0003191_abnormal_cellular_cholesterol0.76496525
144MP0004185_abnormal_adipocyte_glucose0.75617850
145MP0003866_abnormal_defecation0.75565858
146MP0004133_heterotaxia0.74866061
147MP0002822_catalepsy0.73463063
148MP0000759_abnormal_skeletal_muscle0.73415173
149MP0005023_abnormal_wound_healing0.73400187
150MP0003646_muscle_fatigue0.72856178
151MP0003634_abnormal_glial_cell0.72748852
152MP0003943_abnormal_hepatobiliary_system0.71380457
153MP0000467_abnormal_esophagus_morphology0.71213066
154MP0003091_abnormal_cell_migration0.71145031
155MP0001299_abnormal_eye_distance/0.71048613
156MP0001661_extended_life_span0.71036837
157MP0003303_peritoneal_inflammation0.69918067
158MP0004036_abnormal_muscle_relaxation0.69076201
159MP0002896_abnormal_bone_mineralization0.68450595
160MP0005584_abnormal_enzyme/coenzyme_acti0.67564874
161MP0004233_abnormal_muscle_weight0.67531369
162MP0001145_abnormal_male_reproductive0.66129832
163MP0002751_abnormal_autonomic_nervous0.65471562
164MP0003436_decreased_susceptibility_to0.64133759
165MP0000749_muscle_degeneration0.64123574
166MP0010352_gastrointestinal_tract_polyps0.64101738
167MP0001943_abnormal_respiration0.63837969
168MP0005220_abnormal_exocrine_pancreas0.63417985
169MP0002060_abnormal_skin_morphology0.63295862
170MP0005248_abnormal_Harderian_gland0.62776405
171MP0004947_skin_inflammation0.62550603
172MP0002106_abnormal_muscle_physiology0.62226782
173MP0003938_abnormal_ear_development0.62115713
174MP0003075_altered_response_to0.61517151
175MP0002210_abnormal_sex_determination0.60945435
176MP0005174_abnormal_tail_pigmentation0.58921818
177MP0009379_abnormal_foot_pigmentation0.58168642
178MP0005595_abnormal_vascular_smooth0.56004279
179MP0008877_abnormal_DNA_methylation0.55515291
180MP0005195_abnormal_posterior_eye0.53206290
181MP0005379_endocrine/exocrine_gland_phen0.52664452
182MP0010769_abnormal_survival0.52621774
183MP0004381_abnormal_hair_follicle0.52148285
184MP0006072_abnormal_retinal_apoptosis0.51989579
185MP0003137_abnormal_impulse_conducting0.51536654
186MP0001958_emphysema0.51268199

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.84348911
2Absent/shortened dynein arms (HP:0200106)5.84348911
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.67991314
4Peripheral hypomyelination (HP:0007182)4.66239014
5Nasal polyposis (HP:0100582)4.27898093
6Oligodactyly (hands) (HP:0001180)4.23267049
7Increased circulating renin level (HP:0000848)4.03929879
8Focal motor seizures (HP:0011153)4.02391061
9Morphological abnormality of the inner ear (HP:0011390)3.93174869
10Megalencephaly (HP:0001355)3.87791026
11Myokymia (HP:0002411)3.87571085
12Anomalous pulmonary venous return (HP:0010772)3.82602321
13Diplopia (HP:0000651)3.68852318
14Abnormality of binocular vision (HP:0011514)3.68852318
15Abnormal respiratory motile cilium physiology (HP:0012261)3.66426526
16Abnormality of the nasal mucosa (HP:0000433)3.58495104
17Sensory axonal neuropathy (HP:0003390)3.42963398
18Split foot (HP:0001839)3.38803419
19Action tremor (HP:0002345)3.31268252
20Abnormality of the pulmonary veins (HP:0011718)3.28827057
21Obstructive sleep apnea (HP:0002870)3.26766905
22Rhinitis (HP:0012384)3.23456714
23Infertility (HP:0000789)3.21879601
24Deep venous thrombosis (HP:0002625)3.17642397
25Hemorrhage of the eye (HP:0011885)3.15361088
26Rib fusion (HP:0000902)3.15041314
27Febrile seizures (HP:0002373)3.06612980
28Abnormal respiratory epithelium morphology (HP:0012253)3.06342767
29Abnormal respiratory motile cilium morphology (HP:0005938)3.06342767
30Epileptic encephalopathy (HP:0200134)3.02145197
31Abnormality of the 4th metacarpal (HP:0010012)2.99251953
32Abnormality of cochlea (HP:0000375)2.98506139
33Abnormality of the diencephalon (HP:0010662)2.98025783
34Focal seizures (HP:0007359)2.97489360
35Oligodactyly (HP:0012165)2.88924552
36Hyporeflexia of lower limbs (HP:0002600)2.84972783
37Chronic bronchitis (HP:0004469)2.79253087
38Exercise-induced myalgia (HP:0003738)2.78328110
39Abnormal eating behavior (HP:0100738)2.77257393
40Vitreoretinal degeneration (HP:0000655)2.75895589
41Metabolic alkalosis (HP:0200114)2.75311185
42Fibular hypoplasia (HP:0003038)2.74952588
43Chorioretinal atrophy (HP:0000533)2.74619625
44Hemiplegia (HP:0002301)2.72366070
45Cerebral hypomyelination (HP:0006808)2.70687915
46Abnormal ciliary motility (HP:0012262)2.70434337
47Submucous cleft hard palate (HP:0000176)2.67652087
48Complement deficiency (HP:0004431)2.67207524
49Xanthomatosis (HP:0000991)2.65808991
50Elfin facies (HP:0004428)2.65301665
51Hemiparesis (HP:0001269)2.64969491
52Hyperlipoproteinemia (HP:0010980)2.61911856
53Akinesia (HP:0002304)2.60978439
54Insomnia (HP:0100785)2.60121245
55Overriding aorta (HP:0002623)2.58546857
56Congenital sensorineural hearing impairment (HP:0008527)2.58389517
57Dysdiadochokinesis (HP:0002075)2.58319083
58Absent speech (HP:0001344)2.58118421
59Generalized tonic-clonic seizures (HP:0002069)2.56888233
60Ankle clonus (HP:0011448)2.56749335
61Difficulty climbing stairs (HP:0003551)2.54325806
62Truncus arteriosus (HP:0001660)2.51131455
63Myocardial infarction (HP:0001658)2.50950244
64Intrahepatic cholestasis (HP:0001406)2.50921712
65Difficulty running (HP:0009046)2.50907056
66Pigmentary retinal degeneration (HP:0001146)2.50375221
67Abnormality of the common coagulation pathway (HP:0010990)2.50174852
68Hypokalemic alkalosis (HP:0001949)2.49799548
69Abnormal drinking behavior (HP:0030082)2.47626459
70Polydipsia (HP:0001959)2.47626459
71Hyperacusis (HP:0010780)2.46048947
72Macroorchidism (HP:0000053)2.39230865
73Colitis (HP:0002583)2.37109370
74Asymmetric septal hypertrophy (HP:0001670)2.35938118
75Genetic anticipation (HP:0003743)2.34464871
76Bronchitis (HP:0012387)2.33982448
77Decreased central vision (HP:0007663)2.33858057
78Type II lissencephaly (HP:0007260)2.31649277
79Turricephaly (HP:0000262)2.30038285
80Bowel incontinence (HP:0002607)2.26044332
81Renovascular hypertension (HP:0100817)2.25239430
82Megalocornea (HP:0000485)2.23358056
83Spastic gait (HP:0002064)2.22655119
84Sleep apnea (HP:0010535)2.20016865
85Supranuclear gaze palsy (HP:0000605)2.19675213
86Retinal dysplasia (HP:0007973)2.18582817
87Hypoalphalipoproteinemia (HP:0003233)2.18089074
88Cone-rod dystrophy (HP:0000548)2.17783040
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16759774
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.16759774
91Broad metatarsal (HP:0001783)2.14549916
92Atonic seizures (HP:0010819)2.14082901
93Abnormality of complement system (HP:0005339)2.10816546
94Nephronophthisis (HP:0000090)2.10470999
95Anophthalmia (HP:0000528)2.09691047
96Mesangial abnormality (HP:0001966)2.08505234
97Spontaneous abortion (HP:0005268)2.07426352
98Hypomagnesemia (HP:0002917)2.07380380
99Anterior segment dysgenesis (HP:0007700)2.06911836
100Synostosis of carpal bones (HP:0005048)2.05795906
101Recurrent otitis media (HP:0000403)2.05010457
102Male infertility (HP:0003251)2.04640378
103Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04609654
104Type 1 muscle fiber predominance (HP:0003803)2.04028570
105Recurrent bronchitis (HP:0002837)2.03802023
106Flat cornea (HP:0007720)2.02152348
107Hypercholesterolemia (HP:0003124)2.01795463
108Cerebellar dysplasia (HP:0007033)2.01431791
109Progressive cerebellar ataxia (HP:0002073)2.00881654
110Abnormal large intestine physiology (HP:0012700)2.00538381
111Abnormality of the corticospinal tract (HP:0002492)1.99936577
112Prolonged partial thromboplastin time (HP:0003645)1.99895261
113Mildly elevated creatine phosphokinase (HP:0008180)1.98814924
114Abnormality of the intrinsic pathway (HP:0010989)1.97567731
115Spastic tetraparesis (HP:0001285)1.95634258
116Congenital stationary night blindness (HP:0007642)1.95365915
117Premature rupture of membranes (HP:0001788)1.95166863
118Septo-optic dysplasia (HP:0100842)1.93837032
119Muscle fiber splitting (HP:0003555)1.90782264
120Bronchiectasis (HP:0002110)1.89528293
121Cerebral aneurysm (HP:0004944)1.89143299
122Alacrima (HP:0000522)1.89143002
123Ulnar deviation of the wrist (HP:0003049)1.87857445
124Bell-shaped thorax (HP:0001591)1.87643533
125Postural instability (HP:0002172)1.86800434
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.85808574
127Atrophic scars (HP:0001075)1.85771922
128Hyperventilation (HP:0002883)1.85385735
129Limb dystonia (HP:0002451)1.85318310
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85310118
131Abnormal gallbladder physiology (HP:0012438)1.84767254
132Cholecystitis (HP:0001082)1.84767254
133Abnormality of the vitreous humor (HP:0004327)1.84644180
134Abnormality of the ischium (HP:0003174)1.84476169
135Polyphagia (HP:0002591)1.82672614
136Recurrent sinusitis (HP:0011108)1.82486170
137Recurrent gram-negative bacterial infections (HP:0005420)1.82148245
138Mutism (HP:0002300)1.81267001
139Obsessive-compulsive behavior (HP:0000722)1.80176765
140Heterotopia (HP:0002282)1.79659068
141Ankle contracture (HP:0006466)1.78739433
142Mitral stenosis (HP:0001718)1.78272617
143Truncal ataxia (HP:0002078)1.78208373
144Gingival bleeding (HP:0000225)1.77196446
145Optic nerve hypoplasia (HP:0000609)1.77110405
146Aplasia/Hypoplasia of the fibula (HP:0006492)1.76682505
147White forelock (HP:0002211)1.76598540
148Anxiety (HP:0000739)1.75878333
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75744335
150Cerebral inclusion bodies (HP:0100314)1.75635131
151Ulnar bowing (HP:0003031)1.75557924
152Neurofibrillary tangles (HP:0002185)1.75385634
153Abnormality of the fingertips (HP:0001211)1.75132770
154Stroke (HP:0001297)1.74818476
155Dyschromatopsia (HP:0007641)1.74407441
156Urinary bladder sphincter dysfunction (HP:0002839)1.74165597
157Acanthocytosis (HP:0001927)1.73710738
158Absence seizures (HP:0002121)1.73521487
159Increased connective tissue (HP:0009025)1.72516345
160Distal lower limb amyotrophy (HP:0008944)1.72420068
161Back pain (HP:0003418)1.72406414
162Loss of speech (HP:0002371)1.72314053
163Central scotoma (HP:0000603)1.71954016
164Hypoplasia of the corpus callosum (HP:0002079)1.70110427
165Hyperkalemia (HP:0002153)1.69604787
166Dysmetria (HP:0001310)1.68495940
167Gastrointestinal inflammation (HP:0004386)1.68312233
168Missing ribs (HP:0000921)1.66877222
169Stereotypic behavior (HP:0000733)1.66038569
170Exercise-induced muscle cramps (HP:0003710)1.65978917
171Tracheomalacia (HP:0002779)1.65882116
172Mitral valve prolapse (HP:0001634)1.65863040
173Status epilepticus (HP:0002133)1.65823208
174Hypoplastic ischia (HP:0003175)1.65603395
175Laryngomalacia (HP:0001601)1.65467216
176Supernumerary bones of the axial skeleton (HP:0009144)1.65309930
177Congenital malformation of the right heart (HP:0011723)1.63538902
178Double outlet right ventricle (HP:0001719)1.63538902
179Dialeptic seizures (HP:0011146)1.63161656
180Anosmia (HP:0000458)1.62928417
181Protuberant abdomen (HP:0001538)1.62686465
182Tibial bowing (HP:0002982)1.62257949
183Abnormality of magnesium homeostasis (HP:0004921)1.61931948
184Protrusio acetabuli (HP:0003179)1.61616705
185Tubulointerstitial fibrosis (HP:0005576)1.61371241
186Intention tremor (HP:0002080)1.61193531
187Macular degeneration (HP:0000608)1.60624859
188Decreased electroretinogram (ERG) amplitude (HP:0000654)1.60076174
189Myoglobinuria (HP:0002913)1.59848624
190Onion bulb formation (HP:0003383)1.58676301
191Ketosis (HP:0001946)1.57695923
192Bony spicule pigmentary retinopathy (HP:0007737)1.57043815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.93764565
2MARK14.90333319
3CASK4.11536711
4ICK3.78209161
5NTRK23.69850598
6TNK23.58181748
7PDK33.29642126
8PDK43.29642126
9EPHB13.23877367
10PRKD33.15922310
11ERN12.60655479
12TESK12.53113571
13NTRK12.38261430
14FGFR42.21743633
15TAOK32.18946238
16PDGFRA2.18421154
17CAMK1G2.03961608
18PTK2B2.03097078
19PDK21.99395828
20TTN1.95929778
21FES1.94409153
22UHMK11.92612287
23NEK61.87207377
24SIK11.83490171
25PHKG21.75139034
26PHKG11.75139034
27PINK11.71018783
28INSRR1.70052643
29MAP3K71.68685819
30PTK61.50190148
31WNK41.49620098
32EEF2K1.48499009
33MAPK131.47474720
34STK391.44069665
35WNK11.40392646
36SGK2231.39781371
37SGK4941.39781371
38CAMK2G1.35186624
39CAMK1D1.34852185
40DMPK1.34411935
41CAMK2B1.32023322
42TNIK1.28240084
43SIK21.25460195
44TRIB31.25193649
45MINK11.24975892
46MET1.23949612
47STK381.23621613
48STK38L1.20938168
49MAP3K31.19825763
50MARK21.16652981
51DYRK1B1.15403102
52CSK1.13840179
53CAMKK11.13649886
54CDK121.11823694
55JAK11.08698945
56PTK21.05887738
57CAMK2D1.03823693
58TYK21.01349679
59MAP3K21.01323945
60ROCK20.98150783
61DYRK20.97975110
62MTOR0.97325684
63BMX0.96604045
64CDK50.95624483
65TYRO30.94857443
66PRKCH0.91372398
67RET0.91223397
68SGK30.90539629
69CAMK2A0.88386567
70TBK10.88330540
71ERBB20.85983354
72PIK3CA0.84756125
73ROCK10.84233205
74PRKCG0.81416260
75MAPKAPK50.80536746
76DDR20.80293809
77PAK60.77937272
78MAP3K100.77806296
79PLK20.77306208
80LATS10.76986168
81DYRK1A0.76909098
82MAPK150.76884639
83JAK20.76700470
84MAP2K20.74669476
85MAPK100.74087695
86PDK10.72679192
87FGFR20.71696224
88PRKAA20.71474805
89TRPM70.71181540
90PDGFRB0.70698184
91CSNK1D0.70573480
92SGK10.70042855
93CSNK1G20.67716067
94CAMK10.67353491
95MAP3K40.66604303
96PRKD20.65453543
97MAP3K130.65411437
98AKT30.64934380
99RIPK10.64410315
100CDK30.62334968
101MAP4K10.61928065
102RIPK40.61170921
103PNCK0.60612377
104KSR20.58871780
105PBK0.57716027
106CCNB10.57402274
107DAPK20.57204930
108STK110.56643389
109CHUK0.56584182
110MAP3K60.56485967
111CSNK1G30.55767407
112TAOK10.55416806
113HIPK20.55197706
114IRAK10.55150310
115PAK20.54760667
116FRK0.54157815
117MAP2K30.53250310
118MAP3K10.53051958
119PKN10.52546232
120PRKCQ0.52381551
121GSK3A0.52351767
122MST1R0.52330621
123MAPK70.51675601
124MAP2K40.51472446
125MAPK120.49860593
126PKN20.49786138
127MAP3K140.49018599
128IKBKB0.48721359
129CSNK1A1L0.47313336
130IKBKE0.47223000
131OBSCN0.46709469
132JAK30.46107766
133PRKG10.46069660
134ZAP700.45420053
135CSNK1A10.45287345
136SGK20.44841636
137PRKCZ0.44784291
138BRSK10.44285760
139PDPK10.44225470
140FYN0.43371515
141PRKD10.43095614
142CSNK1G10.43037745
143IRAK20.42399763
144RPS6KA30.41364849
145PRKAA10.40580618
146BMPR1B0.40541882
147PIK3CG0.39908592
148ALK0.39486067
149PAK40.39336088
150INSR0.38133325
151FGFR30.37843503
152ERBB40.37792590
153EPHA40.36844887
154CAMK40.35164440
155PAK30.33932749
156CDC42BPA0.33649406
157FGFR10.33503238
158PRKDC0.32935339
159MAP2K10.32642394
160ADRBK10.32031522
161ADRBK20.31004841
162MKNK20.28878629
163LMTK20.27328740
164TIE10.27086586
165SRC0.26551362

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.17730000
2Glutamatergic synapse_Homo sapiens_hsa047242.78259124
3Circadian entrainment_Homo sapiens_hsa047132.78134573
4GABAergic synapse_Homo sapiens_hsa047272.48446725
5Morphine addiction_Homo sapiens_hsa050322.38965144
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.33583758
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.28610369
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07634763
9Fatty acid biosynthesis_Homo sapiens_hsa000611.95755119
10Gastric acid secretion_Homo sapiens_hsa049711.94834246
11Synaptic vesicle cycle_Homo sapiens_hsa047211.86369462
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85277194
13Complement and coagulation cascades_Homo sapiens_hsa046101.84469423
14Cocaine addiction_Homo sapiens_hsa050301.79320953
15Dopaminergic synapse_Homo sapiens_hsa047281.76406980
16PPAR signaling pathway_Homo sapiens_hsa033201.76249682
17Nitrogen metabolism_Homo sapiens_hsa009101.74392271
18ABC transporters_Homo sapiens_hsa020101.65536466
19Lysine degradation_Homo sapiens_hsa003101.65250835
20cAMP signaling pathway_Homo sapiens_hsa040241.63790246
21Fatty acid degradation_Homo sapiens_hsa000711.61538133
22Cholinergic synapse_Homo sapiens_hsa047251.60231152
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58120227
24Propanoate metabolism_Homo sapiens_hsa006401.57524787
25Notch signaling pathway_Homo sapiens_hsa043301.55090512
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53737010
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.47521258
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46621419
29Glioma_Homo sapiens_hsa052141.42826806
30Fatty acid metabolism_Homo sapiens_hsa012121.39378841
31Arginine biosynthesis_Homo sapiens_hsa002201.38634194
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36426782
33Staphylococcus aureus infection_Homo sapiens_hsa051501.35670311
34Long-term depression_Homo sapiens_hsa047301.35348446
35Bile secretion_Homo sapiens_hsa049761.31114869
36Selenocompound metabolism_Homo sapiens_hsa004501.29635397
37Pyruvate metabolism_Homo sapiens_hsa006201.29264674
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27192213
39Long-term potentiation_Homo sapiens_hsa047201.26765924
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.26132594
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25371369
42Glycerolipid metabolism_Homo sapiens_hsa005611.25049408
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24059291
44Sulfur metabolism_Homo sapiens_hsa009201.23617215
45Taste transduction_Homo sapiens_hsa047421.20456972
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16980454
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16932711
48Insulin resistance_Homo sapiens_hsa049311.16680309
49Glucagon signaling pathway_Homo sapiens_hsa049221.16619474
50Axon guidance_Homo sapiens_hsa043601.15428031
51Choline metabolism in cancer_Homo sapiens_hsa052311.14555742
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14351559
53ECM-receptor interaction_Homo sapiens_hsa045121.11673658
54Olfactory transduction_Homo sapiens_hsa047401.11439838
55Oxytocin signaling pathway_Homo sapiens_hsa049211.09962068
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09570539
57Calcium signaling pathway_Homo sapiens_hsa040201.09401690
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09294729
59Serotonergic synapse_Homo sapiens_hsa047261.07848719
60Fat digestion and absorption_Homo sapiens_hsa049751.06733720
61Type II diabetes mellitus_Homo sapiens_hsa049301.04928767
62beta-Alanine metabolism_Homo sapiens_hsa004101.04286307
63Tryptophan metabolism_Homo sapiens_hsa003800.97306868
64Dorso-ventral axis formation_Homo sapiens_hsa043200.95689746
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95461174
66Gap junction_Homo sapiens_hsa045400.93359185
67Ras signaling pathway_Homo sapiens_hsa040140.90826069
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88705915
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88646985
70Sphingolipid metabolism_Homo sapiens_hsa006000.88013417
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87472486
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84318459
73Rap1 signaling pathway_Homo sapiens_hsa040150.84091662
74Pancreatic secretion_Homo sapiens_hsa049720.83825908
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83017850
76Focal adhesion_Homo sapiens_hsa045100.82294221
77Endometrial cancer_Homo sapiens_hsa052130.79663187
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77904520
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.77635010
80B cell receptor signaling pathway_Homo sapiens_hsa046620.77151008
81Circadian rhythm_Homo sapiens_hsa047100.75058389
82Phototransduction_Homo sapiens_hsa047440.73672630
83Protein digestion and absorption_Homo sapiens_hsa049740.72817155
84Hippo signaling pathway_Homo sapiens_hsa043900.72535035
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.72282000
86VEGF signaling pathway_Homo sapiens_hsa043700.70794840
87Peroxisome_Homo sapiens_hsa041460.70703959
88Vitamin B6 metabolism_Homo sapiens_hsa007500.70064398
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70054672
90Proteoglycans in cancer_Homo sapiens_hsa052050.69272592
91Melanogenesis_Homo sapiens_hsa049160.69169883
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65744804
93Insulin secretion_Homo sapiens_hsa049110.65655421
94Chemical carcinogenesis_Homo sapiens_hsa052040.64967509
95Butanoate metabolism_Homo sapiens_hsa006500.64561395
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64445503
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64247603
98Starch and sucrose metabolism_Homo sapiens_hsa005000.64008498
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.63998705
100Retinol metabolism_Homo sapiens_hsa008300.63338589
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62976768
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.62901173
103Thyroid hormone synthesis_Homo sapiens_hsa049180.62308201
104Collecting duct acid secretion_Homo sapiens_hsa049660.61872114
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61728909
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.61501074
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60743565
108GnRH signaling pathway_Homo sapiens_hsa049120.59852514
109Osteoclast differentiation_Homo sapiens_hsa043800.59678118
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59397698
111Amoebiasis_Homo sapiens_hsa051460.59300617
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59115057
113Caffeine metabolism_Homo sapiens_hsa002320.58897678
114Dilated cardiomyopathy_Homo sapiens_hsa054140.57435954
115Melanoma_Homo sapiens_hsa052180.57291318
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.57180374
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57158262
118Ovarian steroidogenesis_Homo sapiens_hsa049130.56658649
119Adherens junction_Homo sapiens_hsa045200.56652350
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56482851
121AMPK signaling pathway_Homo sapiens_hsa041520.56360363
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56015674
123Colorectal cancer_Homo sapiens_hsa052100.55995308
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.53362483
125Ether lipid metabolism_Homo sapiens_hsa005650.52638325
126Estrogen signaling pathway_Homo sapiens_hsa049150.52542401
127Toxoplasmosis_Homo sapiens_hsa051450.52070479
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51442530
129Histidine metabolism_Homo sapiens_hsa003400.50817373
130Linoleic acid metabolism_Homo sapiens_hsa005910.50178359
131Fructose and mannose metabolism_Homo sapiens_hsa000510.50063000
132Inositol phosphate metabolism_Homo sapiens_hsa005620.49079153
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48851429
134Vitamin digestion and absorption_Homo sapiens_hsa049770.48798306
135Endocytosis_Homo sapiens_hsa041440.48739217
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48602647
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47724809
138Cardiac muscle contraction_Homo sapiens_hsa042600.47308633
139mTOR signaling pathway_Homo sapiens_hsa041500.46851100
140Insulin signaling pathway_Homo sapiens_hsa049100.45645347
141Acute myeloid leukemia_Homo sapiens_hsa052210.45136412
142ErbB signaling pathway_Homo sapiens_hsa040120.43708545
143Hedgehog signaling pathway_Homo sapiens_hsa043400.43653994
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42674176
145MAPK signaling pathway_Homo sapiens_hsa040100.42631706
146Renin secretion_Homo sapiens_hsa049240.42619640
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42265345
148Sulfur relay system_Homo sapiens_hsa041220.41978304
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41300966
150Prion diseases_Homo sapiens_hsa050200.41294164
151Arginine and proline metabolism_Homo sapiens_hsa003300.40547973
152MicroRNAs in cancer_Homo sapiens_hsa052060.40205532
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39984919
154Steroid biosynthesis_Homo sapiens_hsa001000.39247116
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39132928
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38802152
157Chronic myeloid leukemia_Homo sapiens_hsa052200.38175154
158Salivary secretion_Homo sapiens_hsa049700.37353171
159Amphetamine addiction_Homo sapiens_hsa050310.36911069

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