COL21A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)4.94669142
2actin-myosin filament sliding (GO:0033275)4.94669142
3cardiac myofibril assembly (GO:0055003)4.72946355
4extracellular fibril organization (GO:0043206)4.56737457
5actin-mediated cell contraction (GO:0070252)4.32359322
6sarcomere organization (GO:0045214)4.28754646
7myofibril assembly (GO:0030239)4.28305165
8axonemal dynein complex assembly (GO:0070286)4.21408400
9collagen fibril organization (GO:0030199)4.19060327
10keratan sulfate catabolic process (GO:0042340)4.16030058
11cell migration involved in heart development (GO:0060973)4.02870138
12cilium or flagellum-dependent cell motility (GO:0001539)4.02738577
13metanephric mesenchyme development (GO:0072075)4.00341165
14neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.79605467
15fibril organization (GO:0097435)3.70513534
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.61571618
17regulation of cardioblast differentiation (GO:0051890)3.56303559
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.51911967
19actomyosin structure organization (GO:0031032)3.49225188
20cardiac muscle cell development (GO:0055013)3.48292536
21cardiac cell development (GO:0055006)3.45479849
22kidney mesenchyme development (GO:0072074)3.41443122
23actin filament-based movement (GO:0030048)3.39820533
24cilium movement (GO:0003341)3.33494686
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.33156338
26cardiac muscle contraction (GO:0060048)3.28646792
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.28513200
28myelination in peripheral nervous system (GO:0022011)3.27057096
29peripheral nervous system axon ensheathment (GO:0032292)3.27057096
30negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.26275542
31protein heterotrimerization (GO:0070208)3.24784053
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.21830610
33motile cilium assembly (GO:0044458)3.21267346
34cardiac muscle hypertrophy (GO:0003300)3.15320086
35striated muscle contraction (GO:0006941)3.14549170
36mesenchyme morphogenesis (GO:0072132)3.12656245
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09012258
38cardiac muscle tissue morphogenesis (GO:0055008)3.08260222
39skeletal muscle contraction (GO:0003009)3.07465552
40muscle tissue morphogenesis (GO:0060415)3.07309679
41regulation of actin filament-based movement (GO:1903115)3.06719462
42collagen catabolic process (GO:0030574)3.06591375
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.03633239
44paraxial mesoderm development (GO:0048339)3.01712630
45ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.01324610
46endocardial cushion morphogenesis (GO:0003203)3.00700995
47planar cell polarity pathway involved in neural tube closure (GO:0090179)3.00484941
48organ induction (GO:0001759)2.98632516
49striated muscle hypertrophy (GO:0014897)2.98198076
50collagen metabolic process (GO:0032963)2.97543069
51left/right pattern formation (GO:0060972)2.95025789
52prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.93091311
53cardiac chamber formation (GO:0003207)2.90354719
54coronary vasculature morphogenesis (GO:0060977)2.88937009
55lateral sprouting from an epithelium (GO:0060601)2.88811172
56camera-type eye morphogenesis (GO:0048593)2.88038136
57positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.86292435
58regulation of the force of heart contraction (GO:0002026)2.82259191
59G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.82064825
60multicellular organismal macromolecule metabolic process (GO:0044259)2.81497248
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80845814
62cell communication by electrical coupling (GO:0010644)2.80585086
63multicellular organismal catabolic process (GO:0044243)2.79140722
64regulation of relaxation of muscle (GO:1901077)2.77697544
65heart morphogenesis (GO:0003007)2.77260427
66regulation of secondary heart field cardioblast proliferation (GO:0003266)2.76979435
67regulation of cardioblast proliferation (GO:0003264)2.76979435
68negative regulation of potassium ion transmembrane transport (GO:1901380)2.75884405
69heart valve formation (GO:0003188)2.73640388
70epithelial cilium movement (GO:0003351)2.72836198
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72445870
72smooth muscle tissue development (GO:0048745)2.71372595
73skeletal muscle tissue development (GO:0007519)2.70422501
74regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.70416976
75outflow tract septum morphogenesis (GO:0003148)2.69284234
76muscle hypertrophy (GO:0014896)2.68980738
77negative regulation of chondrocyte differentiation (GO:0032331)2.66846570
78response to inactivity (GO:0014854)2.66789939
79bone trabecula formation (GO:0060346)2.66267199
80multicellular organismal metabolic process (GO:0044236)2.64432226
81hippo signaling (GO:0035329)2.63438572
82glomerulus development (GO:0032835)2.63412236
83sarcoplasmic reticulum calcium ion transport (GO:0070296)2.61993006
84regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.61623594
85cardiac ventricle formation (GO:0003211)2.61613210
86establishment of planar polarity (GO:0001736)2.61366865
87establishment of tissue polarity (GO:0007164)2.61366865
88extracellular matrix assembly (GO:0085029)2.60836153
89muscle cell fate commitment (GO:0042693)2.58284194
90regulation of cell communication by electrical coupling (GO:0010649)2.58245134
91Notch signaling involved in heart development (GO:0061314)2.58066597
92regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57831996
93muscle tissue development (GO:0060537)2.55566513
94endocrine hormone secretion (GO:0060986)2.55456180
95trabecula formation (GO:0060343)2.55446324
96regulation of cardiac muscle cell differentiation (GO:2000725)2.55110223
97myoblast fusion (GO:0007520)2.54693094
98cell differentiation involved in metanephros development (GO:0072202)2.54479724
99negative regulation of catenin import into nucleus (GO:0035414)2.54399438
100striated muscle tissue development (GO:0014706)2.54157526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.48642870
2EP300_21415370_ChIP-Seq_HL-1_Mouse2.86450829
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71640679
4GBX2_23144817_ChIP-Seq_PC3_Human2.51121042
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.45218502
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40565521
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24374681
8EZH2_22144423_ChIP-Seq_EOC_Human2.19020527
9* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.15952308
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13431496
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.02646447
12WT1_19549856_ChIP-ChIP_CCG9911_Human1.97612548
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96939406
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95360036
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95360036
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93136487
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90313967
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84760310
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.83039011
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.79754629
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78950630
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.77714985
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68259304
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64545057
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58628218
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.58304381
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57315922
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56596959
29TAF15_26573619_Chip-Seq_HEK293_Human1.54329192
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53568314
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52493565
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.51283930
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.51283930
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50693065
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50490398
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.50435529
37SMAD4_21799915_ChIP-Seq_A2780_Human1.50282939
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50258214
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48534937
40TP53_18474530_ChIP-ChIP_U2OS_Human1.48195711
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47833600
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47794066
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46927962
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44996546
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43350258
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40555915
47AR_21572438_ChIP-Seq_LNCaP_Human1.38768267
48* CJUN_26792858_Chip-Seq_BT549_Human1.35508013
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.35266583
50AHR_22903824_ChIP-Seq_MCF-7_Human1.34441033
51DROSHA_22980978_ChIP-Seq_HELA_Human1.33620150
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33412279
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33357710
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.33181196
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.33181196
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32663904
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30970335
58YAP1_20516196_ChIP-Seq_MESCs_Mouse1.30622952
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.30137477
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28626999
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.28338889
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27691302
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26022985
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23852690
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22550351
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22359289
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.22301843
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22202982
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21545980
70* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20412951
71* SMAD3_21741376_ChIP-Seq_HESCs_Human1.20083901
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19797719
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19091688
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18355530
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17584631
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17354346
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16529456
78TP53_16413492_ChIP-PET_HCT116_Human1.15405707
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15281908
80FUS_26573619_Chip-Seq_HEK293_Human1.12189994
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11707623
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.11523571
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11397358
84* SMAD4_21741376_ChIP-Seq_HESCs_Human1.11095533
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10492171
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.09923859
87P300_19829295_ChIP-Seq_ESCs_Human1.08328434
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.08119153
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07507500
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06423560
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06108901
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05992655
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05429683
94MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03443658
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03143490
96CLOCK_20551151_ChIP-Seq_293T_Human1.01638600
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01535294
98BCAT_22108803_ChIP-Seq_LS180_Human0.98911184
99RNF2_27304074_Chip-Seq_NSC_Mouse0.98699701
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.97777675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.94681775
2MP0005503_abnormal_tendon_morphology5.84321408
3MP0005275_abnormal_skin_tensile5.83991982
4MP0000751_myopathy3.48320898
5MP0004272_abnormal_basement_membrane3.26711635
6MP0002108_abnormal_muscle_morphology2.79436532
7MP0004084_abnormal_cardiac_muscle2.74807975
8MP0003279_aneurysm2.50429770
9MP0001958_emphysema2.33691206
10MP0010368_abnormal_lymphatic_system2.22570240
11MP0004036_abnormal_muscle_relaxation2.09128406
12MP0010030_abnormal_orbit_morphology1.99228051
13MP0009780_abnormal_chondrocyte_physiolo1.96643509
14MP0003705_abnormal_hypodermis_morpholog1.84850743
15MP0004087_abnormal_muscle_fiber1.78488652
16MP0004215_abnormal_myocardial_fiber1.77321722
17MP0000749_muscle_degeneration1.73170071
18MP0005369_muscle_phenotype1.64001778
19MP0005508_abnormal_skeleton_morphology1.61102734
20MP0005620_abnormal_muscle_contractility1.59445707
21MP0000750_abnormal_muscle_regeneration1.58866442
22MP0009384_cardiac_valve_regurgitation1.57869148
23MP0001879_abnormal_lymphatic_vessel1.55993673
24MP0003942_abnormal_urinary_system1.54580447
25MP0004145_abnormal_muscle_electrophysio1.53348050
26MP0000534_abnormal_ureter_morphology1.52201764
27MP0000013_abnormal_adipose_tissue1.49714529
28MP0005330_cardiomyopathy1.49589530
29MP0005623_abnormal_meninges_morphology1.49196911
30MP0000767_abnormal_smooth_muscle1.48087881
31MP0000733_abnormal_muscle_development1.47922997
32MP0002106_abnormal_muscle_physiology1.44386467
33MP0002972_abnormal_cardiac_muscle1.43066989
34MP0010630_abnormal_cardiac_muscle1.41146761
35MP0003941_abnormal_skin_development1.40889052
36MP0001299_abnormal_eye_distance/1.36609106
37MP0003122_maternal_imprinting1.33709976
38MP0009250_abnormal_appendicular_skeleto1.29928157
39MP0000747_muscle_weakness1.28103103
40MP0003385_abnormal_body_wall1.25878458
41MP0002060_abnormal_skin_morphology1.24559766
42MP0000759_abnormal_skeletal_muscle1.23776365
43MP0002127_abnormal_cardiovascular_syste1.23672202
44MP0006138_congestive_heart_failure1.23282721
45MP0005257_abnormal_intraocular_pressure1.23116457
46MP0002282_abnormal_trachea_morphology1.20300020
47MP0002837_dystrophic_cardiac_calcinosis1.14025730
48MP0003950_abnormal_plasma_membrane1.12078393
49MP0001544_abnormal_cardiovascular_syste1.10366224
50MP0005385_cardiovascular_system_phenoty1.10366224
51MP0002896_abnormal_bone_mineralization1.05368853
52MP0003937_abnormal_limbs/digits/tail_de1.05316843
53MP0000049_abnormal_middle_ear1.04688349
54MP0008004_abnormal_stomach_pH1.04270360
55MP0000762_abnormal_tongue_morphology1.04115435
56MP0004484_altered_response_of1.03670348
57MP0001542_abnormal_bone_strength1.03078612
58MP0008775_abnormal_heart_ventricle1.02787576
59MP0003935_abnormal_craniofacial_develop1.01548747
60MP0004085_abnormal_heartbeat1.01195317
61MP0003137_abnormal_impulse_conducting1.00994308
62MP0002269_muscular_atrophy0.96423861
63MP0002249_abnormal_larynx_morphology0.95463743
64MP0002128_abnormal_blood_circulation0.94556514
65MP0000566_synostosis0.92234340
66MP0000266_abnormal_heart_morphology0.91133262
67MP0002295_abnormal_pulmonary_circulatio0.89128811
68MP0002233_abnormal_nose_morphology0.86679504
69MP0000462_abnormal_digestive_system0.86385225
70MP0002932_abnormal_joint_morphology0.86169749
71MP0000428_abnormal_craniofacial_morphol0.84940957
72MP0000432_abnormal_head_morphology0.84399116
73MP0002697_abnormal_eye_size0.82506904
74MP0003115_abnormal_respiratory_system0.82107088
75MP0006054_spinal_hemorrhage0.81870855
76MP0003755_abnormal_palate_morphology0.81606793
77MP0002116_abnormal_craniofacial_bone0.81136418
78MP0002115_abnormal_skeleton_extremities0.81117732
79MP0005595_abnormal_vascular_smooth0.79806898
80MP0000003_abnormal_adipose_tissue0.77369056
81MP0000537_abnormal_urethra_morphology0.74784581
82MP0005388_respiratory_system_phenotype0.74760729
83MP0002133_abnormal_respiratory_system0.74760729
84MP0002925_abnormal_cardiovascular_devel0.73771344
85MP0002009_preneoplasia0.73321006
86MP0001614_abnormal_blood_vessel0.72931179
87MP0003567_abnormal_fetal_cardiomyocyte0.72616446
88MP0000163_abnormal_cartilage_morphology0.72602776
89MP0005187_abnormal_penis_morphology0.72505088
90MP0002114_abnormal_axial_skeleton0.72181753
91MP0001984_abnormal_olfaction0.71816902
92MP0002109_abnormal_limb_morphology0.70307498
93MP0005023_abnormal_wound_healing0.66844765
94MP0001243_abnormal_dermal_layer0.65822468
95MP0001661_extended_life_span0.63961664
96MP0002168_other_aberrant_phenotype0.63450744
97MP0005409_darkened_coat_color0.62666530
98MP0005248_abnormal_Harderian_gland0.61372736
99MP0004270_analgesia0.59370592
100MP0003566_abnormal_cell_adhesion0.58875936

Predicted human phenotypes

RankGene SetZ-score
1Distal arthrogryposis (HP:0005684)4.77941225
2Premature rupture of membranes (HP:0001788)4.20806628
3Aortic dissection (HP:0002647)4.19270522
4Calcaneovalgus deformity (HP:0001848)4.00450431
5Protrusio acetabuli (HP:0003179)3.85326607
6Type 1 muscle fiber predominance (HP:0003803)3.76253179
7Atrophic scars (HP:0001075)3.75315556
8Soft skin (HP:0000977)3.73731304
9Round ear (HP:0100830)3.67133480
10Deformed tarsal bones (HP:0008119)3.56314111
11Breech presentation (HP:0001623)3.46074226
12Popliteal pterygium (HP:0009756)3.33440550
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.28705033
14Bladder diverticulum (HP:0000015)3.28088231
15Ulnar deviation of the wrist (HP:0003049)3.21329916
16Neonatal short-limb short stature (HP:0008921)3.19440210
17Sudden death (HP:0001699)3.18125307
18Pulmonary artery stenosis (HP:0004415)3.16196233
19Fetal akinesia sequence (HP:0001989)3.07862146
20Abnormal ciliary motility (HP:0012262)3.07183938
21Limited hip movement (HP:0008800)3.03124575
22Abnormal respiratory motile cilium physiology (HP:0012261)2.99850685
23Abnormal respiratory motile cilium morphology (HP:0005938)2.98571445
24Abnormal respiratory epithelium morphology (HP:0012253)2.98571445
25Abnormality of the ischium (HP:0003174)2.96420854
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.96234813
27Absent/shortened dynein arms (HP:0200106)2.96234813
28Aortic aneurysm (HP:0004942)2.96223368
29Rhinitis (HP:0012384)2.86761003
30Abnormality of the calf musculature (HP:0001430)2.81636872
31Fragile skin (HP:0001030)2.77899082
32Aplasia of the musculature (HP:0100854)2.72333601
33Muscle fiber splitting (HP:0003555)2.70631141
34Cutaneous syndactyly (HP:0012725)2.67609257
35Hip contracture (HP:0003273)2.66963822
36Neoplasm of the heart (HP:0100544)2.61559110
37Cutaneous finger syndactyly (HP:0010554)2.59274081
38Mitral valve prolapse (HP:0001634)2.59006040
39Broad metatarsal (HP:0001783)2.57405631
40Vascular tortuosity (HP:0004948)2.52377245
41Abnormality of the calcaneus (HP:0008364)2.49912991
42Nemaline bodies (HP:0003798)2.49108689
43Absent phalangeal crease (HP:0006109)2.48039768
44Cerebral aneurysm (HP:0004944)2.47377336
45Bell-shaped thorax (HP:0001591)2.47241751
46Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.45092399
47Abnormality of dentin (HP:0010299)2.43179264
48Abnormal delivery (HP:0001787)2.42436373
49Wide anterior fontanel (HP:0000260)2.42274073
50Hyporeflexia of lower limbs (HP:0002600)2.41274635
51Atrial fibrillation (HP:0005110)2.40264420
52Ventricular tachycardia (HP:0004756)2.39080422
53Hypoplastic ischia (HP:0003175)2.37421828
54Infantile muscular hypotonia (HP:0008947)2.33074600
55Arterial tortuosity (HP:0005116)2.31413524
56Midline defect of the nose (HP:0004122)2.27500186
57Peritonitis (HP:0002586)2.27423029
58Lipoatrophy (HP:0100578)2.24129394
59Abnormal finger flexion creases (HP:0006143)2.23712238
60Shallow orbits (HP:0000586)2.23565454
61Muscle fiber inclusion bodies (HP:0100299)2.23233875
62Subaortic stenosis (HP:0001682)2.22687767
63Abnormality of the left ventricular outflow tract (HP:0011103)2.22687767
64Genu recurvatum (HP:0002816)2.21886889
65Bundle branch block (HP:0011710)2.20998199
66Short 4th metacarpal (HP:0010044)2.20350806
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20350806
68Turricephaly (HP:0000262)2.19905392
69Thin ribs (HP:0000883)2.16184085
70Morphological abnormality of the middle ear (HP:0008609)2.16048156
71Dilatation of the ascending aorta (HP:0005111)2.14448574
72Mildly elevated creatine phosphokinase (HP:0008180)2.08703317
73Long clavicles (HP:0000890)2.07502662
74Primary atrial arrhythmia (HP:0001692)2.06871102
75Mild short stature (HP:0003502)2.05112797
76Coronal craniosynostosis (HP:0004440)2.04179312
77Lymphangioma (HP:0100764)2.02871864
78Hyperextensible skin (HP:0000974)2.02732253
79Trismus (HP:0000211)1.98242622
80Supraventricular arrhythmia (HP:0005115)1.97768521
81Metatarsus adductus (HP:0001840)1.93510687
82Overgrowth (HP:0001548)1.93136763
83Calf muscle hypertrophy (HP:0008981)1.92808398
84Supraventricular tachycardia (HP:0004755)1.91905890
85Bowel diverticulosis (HP:0005222)1.88427279
86Malignant hyperthermia (HP:0002047)1.87457250
87Renovascular hypertension (HP:0100817)1.80238289
88Increased variability in muscle fiber diameter (HP:0003557)1.78790083
89Right ventricular cardiomyopathy (HP:0011663)1.77300190
90Osteolytic defects of the hand bones (HP:0009699)1.76815060
91Osteolytic defects of the phalanges of the hand (HP:0009771)1.76815060
92Absent frontal sinuses (HP:0002688)1.74886279
93Osteoarthritis (HP:0002758)1.73127851
94Joint laxity (HP:0001388)1.72361129
95Chronic bronchitis (HP:0004469)1.72245839
96Knee flexion contracture (HP:0006380)1.71051836
97Hypoplasia of the iris (HP:0007676)1.69509299
98Chin dimple (HP:0010751)1.68146802
99Camptodactyly of toe (HP:0001836)1.67659580
100Vertebral arch anomaly (HP:0008438)1.67398712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.77269672
2MYLK3.75202174
3OBSCN3.26326467
4PIK3CG3.18801242
5DDR23.12377042
6DMPK2.73431572
7BRD42.68471638
8MAPK152.67111345
9PDGFRA2.44909655
10TIE12.31282583
11TNIK2.27328511
12EPHB22.24134768
13TTN2.14953061
14STK38L2.08536649
15LATS22.01762471
16STK241.92377761
17EEF2K1.88265964
18NTRK11.80866500
19NEK91.60472543
20FGFR21.56840057
21RIPK11.48149532
22PIK3CA1.28896283
23ROCK11.26460898
24ROCK21.23832564
25STK391.21419474
26TRIB31.11545493
27FGFR11.11528255
28EPHA31.11274171
29MARK11.10904909
30PDGFRB1.09574691
31MAP3K101.07333360
32MOS1.07261514
33MAP3K71.06708916
34MET1.06122194
35FGFR41.02575040
36MUSK0.99590239
37PAK20.98839301
38MAPKAPK30.95879349
39TRPM70.86676360
40ILK0.85422522
41CASK0.83150509
42MAP3K20.82828418
43SGK20.82537316
44MAPK70.78935474
45NTRK30.74213707
46FER0.73346028
47PRKCE0.72789760
48NLK0.72241236
49PRKD10.70899905
50STK30.66322401
51RPS6KA20.66242187
52CAMK2D0.65439867
53RPS6KC10.64648361
54RPS6KL10.64648361
55BCR0.64353747
56RET0.63998790
57CDK30.62306649
58AKT30.62149064
59MST40.62054596
60PTK20.61981286
61PKN20.61872481
62MTOR0.61855143
63MKNK20.60994495
64MARK20.58413139
65GRK70.58023601
66WNK10.57598463
67CAMK2G0.57139657
68NTRK20.57055444
69PAK30.56649291
70SGK2230.55905263
71SGK4940.55905263
72CAMK2A0.55741519
73RPS6KB10.55644563
74STK380.54660781
75DYRK1B0.54068059
76CDC42BPA0.53661914
77PTK2B0.53301976
78TGFBR20.53225253
79RPS6KA60.52901249
80ICK0.52414566
81PNCK0.50028891
82MAPK120.48430157
83AKT20.48161646
84SGK30.48023732
85PRKG10.47178091
86MAPK100.46146941
87CAMK40.44663585
88OXSR10.44201490
89CDK120.43706969
90KSR20.42594433
91INSRR0.41325332
92MAP2K10.39111403
93CAMK1G0.38580748
94ADRBK10.37204771
95MKNK10.36576419
96PRKAA10.36465331
97TGFBR10.35880287
98DAPK30.35042762
99RPS6KA30.33143131
100CAMK2B0.32198786

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054144.00581050
2ECM-receptor interaction_Homo sapiens_hsa045123.82331929
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.76544681
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.25301390
5* Protein digestion and absorption_Homo sapiens_hsa049742.95376334
6Focal adhesion_Homo sapiens_hsa045102.53865943
7Tight junction_Homo sapiens_hsa045302.06613002
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99553502
9Adherens junction_Homo sapiens_hsa045201.97055124
10Amoebiasis_Homo sapiens_hsa051461.89039037
11Cardiac muscle contraction_Homo sapiens_hsa042601.82792691
12Renin secretion_Homo sapiens_hsa049241.74926205
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.67367708
14cGMP-PKG signaling pathway_Homo sapiens_hsa040221.66741413
15Basal cell carcinoma_Homo sapiens_hsa052171.62223704
16Hedgehog signaling pathway_Homo sapiens_hsa043401.57132193
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42902961
18Hippo signaling pathway_Homo sapiens_hsa043901.35280870
19Gap junction_Homo sapiens_hsa045401.30577964
20Axon guidance_Homo sapiens_hsa043601.30267761
21Circadian entrainment_Homo sapiens_hsa047131.28914707
22* Proteoglycans in cancer_Homo sapiens_hsa052051.27237811
23Melanogenesis_Homo sapiens_hsa049161.25893493
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25505528
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23614863
26Small cell lung cancer_Homo sapiens_hsa052221.21991611
27Salivary secretion_Homo sapiens_hsa049701.20936242
28TGF-beta signaling pathway_Homo sapiens_hsa043501.19116667
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16923926
30Circadian rhythm_Homo sapiens_hsa047101.16494078
31cAMP signaling pathway_Homo sapiens_hsa040241.15997315
32Calcium signaling pathway_Homo sapiens_hsa040201.15170666
33Oxytocin signaling pathway_Homo sapiens_hsa049211.13616005
34Gastric acid secretion_Homo sapiens_hsa049711.12691401
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05721223
36Dorso-ventral axis formation_Homo sapiens_hsa043201.04137105
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02872836
38Ovarian steroidogenesis_Homo sapiens_hsa049130.98537936
39Wnt signaling pathway_Homo sapiens_hsa043100.96823689
40Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96709439
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93697437
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91674948
43Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90898870
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89372805
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87826861
46Melanoma_Homo sapiens_hsa052180.86994076
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85977245
48Pathways in cancer_Homo sapiens_hsa052000.85622674
49Thyroid hormone synthesis_Homo sapiens_hsa049180.84908218
50Rap1 signaling pathway_Homo sapiens_hsa040150.83772892
51Prion diseases_Homo sapiens_hsa050200.83620306
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.83120749
53Amphetamine addiction_Homo sapiens_hsa050310.82580046
54MicroRNAs in cancer_Homo sapiens_hsa052060.82118171
55Cocaine addiction_Homo sapiens_hsa050300.81878463
56Prostate cancer_Homo sapiens_hsa052150.81357604
57Histidine metabolism_Homo sapiens_hsa003400.77976791
58Phenylalanine metabolism_Homo sapiens_hsa003600.76800796
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76718610
60Endometrial cancer_Homo sapiens_hsa052130.76260656
61Pancreatic secretion_Homo sapiens_hsa049720.73039108
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71432426
63GnRH signaling pathway_Homo sapiens_hsa049120.71161368
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.71099462
65Platelet activation_Homo sapiens_hsa046110.70531746
66Ras signaling pathway_Homo sapiens_hsa040140.69356412
67Notch signaling pathway_Homo sapiens_hsa043300.69018450
68Long-term potentiation_Homo sapiens_hsa047200.67105971
69Insulin secretion_Homo sapiens_hsa049110.66930353
70Renin-angiotensin system_Homo sapiens_hsa046140.66556179
71Glutamatergic synapse_Homo sapiens_hsa047240.65555553
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63266063
73Renal cell carcinoma_Homo sapiens_hsa052110.62574845
74Estrogen signaling pathway_Homo sapiens_hsa049150.61683084
75Cholinergic synapse_Homo sapiens_hsa047250.61036762
76Glioma_Homo sapiens_hsa052140.59210544
77Tyrosine metabolism_Homo sapiens_hsa003500.56182493
78Long-term depression_Homo sapiens_hsa047300.55613584
79Insulin signaling pathway_Homo sapiens_hsa049100.55472157
80Choline metabolism in cancer_Homo sapiens_hsa052310.52551828
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51061382
82Taste transduction_Homo sapiens_hsa047420.49732753
83Bile secretion_Homo sapiens_hsa049760.49130895
84Thyroid cancer_Homo sapiens_hsa052160.47649995
85Propanoate metabolism_Homo sapiens_hsa006400.46137704
86Chemical carcinogenesis_Homo sapiens_hsa052040.45184906
87Colorectal cancer_Homo sapiens_hsa052100.43471563
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40626939
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40214167
90ABC transporters_Homo sapiens_hsa020100.39227136
91Fatty acid degradation_Homo sapiens_hsa000710.39176612
92AMPK signaling pathway_Homo sapiens_hsa041520.38606012
93Serotonergic synapse_Homo sapiens_hsa047260.38416177
94beta-Alanine metabolism_Homo sapiens_hsa004100.38373159
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38131751
96Lysine degradation_Homo sapiens_hsa003100.37808169
97Insulin resistance_Homo sapiens_hsa049310.36578207
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.36540526
99Dopaminergic synapse_Homo sapiens_hsa047280.35054337
100Glucagon signaling pathway_Homo sapiens_hsa049220.34294765

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »