COL23A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: COL23A1 is a member of the transmembrane collagens, a subfamily of the nonfibrillar collagens that contain a single pass hydrophobic transmembrane domain (Banyard et al., 2003 [PubMed 12644459]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)7.41828923
2regulation of branching involved in prostate gland morphogenesis (GO:0060687)6.52320539
3regulation of mononuclear cell migration (GO:0071675)5.75997981
4cell proliferation involved in metanephros development (GO:0072203)5.52519999
5cell proliferation involved in kidney development (GO:0072111)5.35150044
6glycosphingolipid catabolic process (GO:0046479)5.33684581
7negative regulation of interleukin-12 production (GO:0032695)5.32187684
8response to peptidoglycan (GO:0032494)5.04913878
9cellular response to thyroid hormone stimulus (GO:0097067)4.99059901
10regulation of vitamin D biosynthetic process (GO:0060556)4.96702626
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.90399257
12mesenchymal-epithelial cell signaling (GO:0060638)4.90021172
13positive regulation of heat generation (GO:0031652)4.88501158
14glycolipid catabolic process (GO:0019377)4.75248111
15mesenchymal cell proliferation (GO:0010463)4.67274721
16oligosaccharide catabolic process (GO:0009313)4.60784250
17regulation of fever generation (GO:0031620)4.57865918
18bone trabecula formation (GO:0060346)4.56709220
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.54240067
20amino sugar catabolic process (GO:0046348)4.48090928
21positive regulation of chemokine biosynthetic process (GO:0045080)4.48059583
22prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.42031955
23neutrophil activation involved in immune response (GO:0002283)4.33449039
24negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.32242788
25radial glial cell differentiation (GO:0060019)4.31446479
26ceramide catabolic process (GO:0046514)4.21806787
27regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.21606734
28branching involved in salivary gland morphogenesis (GO:0060445)4.17924375
29regulation of cytokine secretion involved in immune response (GO:0002739)4.16436002
30T-helper 1 type immune response (GO:0042088)4.15679999
31response to thyroid hormone (GO:0097066)4.14261925
32regulation of podosome assembly (GO:0071801)4.12369989
33regulation of chemokine biosynthetic process (GO:0045073)4.11567468
34regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.10937134
35convergent extension (GO:0060026)4.10310429
36craniofacial suture morphogenesis (GO:0097094)4.01905939
37negative regulation of chondrocyte differentiation (GO:0032331)3.99823287
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.94311674
39macrophage differentiation (GO:0030225)3.87458491
40regulation of non-canonical Wnt signaling pathway (GO:2000050)3.84129515
41positive regulation of p38MAPK cascade (GO:1900745)3.79517440
42monocyte chemotaxis (GO:0002548)3.77726181
43negative regulation of catenin import into nucleus (GO:0035414)3.77561071
44membrane lipid catabolic process (GO:0046466)3.76638750
45regulation of heat generation (GO:0031650)3.76480245
46regulation of vitamin metabolic process (GO:0030656)3.75271566
47negative regulation of cytokine production involved in immune response (GO:0002719)3.72969053
48virion attachment to host cell (GO:0019062)3.69189147
49adhesion of symbiont to host cell (GO:0044650)3.69189147
50mesenchyme morphogenesis (GO:0072132)3.68027644
51negative regulation of nitric oxide biosynthetic process (GO:0045019)3.63254256
52mesonephros development (GO:0001823)3.62834219
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.61082301
54macrophage activation involved in immune response (GO:0002281)3.59387368
55N-acetylneuraminate metabolic process (GO:0006054)3.57593126
56polarized epithelial cell differentiation (GO:0030859)3.57384735
57sphingolipid catabolic process (GO:0030149)3.55593788
58mesenchymal cell differentiation (GO:0048762)3.54907045
59renal system development (GO:0072001)3.54774994
60establishment of apical/basal cell polarity (GO:0035089)3.53897685
61regulation of macrophage chemotaxis (GO:0010758)3.52066817
62axis elongation (GO:0003401)3.43122688
63hindlimb morphogenesis (GO:0035137)3.41982034
64endocardial cushion morphogenesis (GO:0003203)3.41256393
65branching involved in labyrinthine layer morphogenesis (GO:0060670)3.40530649
66regulation of membrane protein ectodomain proteolysis (GO:0051043)3.38382128
67Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.37602398
68paraxial mesoderm development (GO:0048339)3.36967389
69sphingosine metabolic process (GO:0006670)3.36660245
70negative regulation of cartilage development (GO:0061037)3.35925497
71keratinocyte proliferation (GO:0043616)3.32884761
72NIK/NF-kappaB signaling (GO:0038061)3.30737041
73outer ear morphogenesis (GO:0042473)3.30682882
74positive regulation of mast cell degranulation (GO:0043306)3.29572581
75positive regulation of mast cell activation involved in immune response (GO:0033008)3.29572581
76regulation of chronic inflammatory response (GO:0002676)3.29111858
77immunoglobulin mediated immune response (GO:0016064)3.28492275
78branching involved in prostate gland morphogenesis (GO:0060442)3.28307752
79positive regulation of leukocyte degranulation (GO:0043302)3.27128012
80cochlea morphogenesis (GO:0090103)3.26425989
81negative regulation of myeloid cell apoptotic process (GO:0033033)3.26414992
82sequestering of extracellular ligand from receptor (GO:0035581)3.26259547
83regulation of mast cell degranulation (GO:0043304)3.24894373
84regulation of T-helper 1 cell differentiation (GO:0045625)3.24836628
85adenosine receptor signaling pathway (GO:0001973)3.24612959
86negative regulation of erythrocyte differentiation (GO:0045647)3.24458868
87response to muramyl dipeptide (GO:0032495)3.23708001
88regulation of establishment of planar polarity (GO:0090175)3.22235798
89proximal/distal pattern formation (GO:0009954)3.21477524
90adhesion of symbiont to host (GO:0044406)3.20591180
91cranial suture morphogenesis (GO:0060363)3.20041393
92neuron projection extension involved in neuron projection guidance (GO:1902284)3.19707020
93axon extension involved in axon guidance (GO:0048846)3.19707020
94renal filtration (GO:0097205)3.17314893
95prostate gland epithelium morphogenesis (GO:0060740)3.16593048
96regulation of cholesterol storage (GO:0010885)3.15830335
97lung-associated mesenchyme development (GO:0060484)3.14952496
98organ induction (GO:0001759)3.12910508
99digestive tract morphogenesis (GO:0048546)3.12196111
100regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11859666
101non-canonical Wnt signaling pathway (GO:0035567)3.10958062
102establishment or maintenance of monopolar cell polarity (GO:0061339)3.10624395
103establishment of monopolar cell polarity (GO:0061162)3.10624395
104positive regulation of monocyte chemotaxis (GO:0090026)3.09674293
105embryonic hindlimb morphogenesis (GO:0035116)3.09624052
106regulation of heart morphogenesis (GO:2000826)3.09605408
107mesodermal cell differentiation (GO:0048333)3.09476043
108limb bud formation (GO:0060174)3.08437498
109regulation of organ formation (GO:0003156)3.07734379
110granulocyte activation (GO:0036230)3.07472966
111regulation of nitric oxide biosynthetic process (GO:0045428)3.05239338
112dorsal/ventral axis specification (GO:0009950)3.05184794
113barbed-end actin filament capping (GO:0051016)3.05157789
114regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.04085871
115branch elongation of an epithelium (GO:0060602)3.04081342
116somite development (GO:0061053)3.03952964
117head development (GO:0060322)3.03899775
118activation of MAPKKK activity (GO:0000185)3.02826265
119anatomical structure regression (GO:0060033)3.02312173
120myeloid dendritic cell differentiation (GO:0043011)3.01871463
121establishment of tissue polarity (GO:0007164)3.01841767
122establishment of planar polarity (GO:0001736)3.01841767
123cellular response to arsenic-containing substance (GO:0071243)3.01773634
124negative regulation of axon extension involved in axon guidance (GO:0048843)3.00516222
125glomerular filtration (GO:0003094)3.00338270
126cellular response to lipopolysaccharide (GO:0071222)2.99866505
127otic vesicle formation (GO:0030916)2.99356996
128kidney mesenchyme development (GO:0072074)2.97924472
129germinal center formation (GO:0002467)2.97743234
130negative regulation of production of molecular mediator of immune response (GO:0002701)2.96774655
131regulation of leukocyte degranulation (GO:0043300)2.95483108
132regulation of mast cell activation involved in immune response (GO:0033006)2.94470136
133positive regulation of mesenchymal cell proliferation (GO:0002053)2.94069985
134negative regulation of embryonic development (GO:0045992)2.93008970
135embryonic cranial skeleton morphogenesis (GO:0048701)2.92520754
136positive regulation by symbiont of host defense response (GO:0052509)2.91221784
137modulation by symbiont of host defense response (GO:0052031)2.91221784
138modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91221784
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91221784
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.91221784
141modulation by symbiont of host immune response (GO:0052553)2.91221784
142lung lobe morphogenesis (GO:0060463)2.88797268
143regulation of chondrocyte differentiation (GO:0032330)2.88336328
144organ formation (GO:0048645)2.87910047
145positive regulation of mast cell activation (GO:0033005)2.87715170
146cellular response to molecule of bacterial origin (GO:0071219)2.87110655
147diol metabolic process (GO:0034311)2.86563711
148glial cell migration (GO:0008347)2.85678124
149regulation of secondary heart field cardioblast proliferation (GO:0003266)2.85192393
150regulation of cardioblast proliferation (GO:0003264)2.85192393
151pinocytosis (GO:0006907)2.84459717
152positive regulation of gastrulation (GO:2000543)2.83768313
153positive regulation of cholesterol efflux (GO:0010875)2.83308525
154regulation of cartilage development (GO:0061035)2.82946507
155pharyngeal system development (GO:0060037)2.82289171
156regulation of mesenchymal cell proliferation (GO:0010464)2.82226483
157regulation of interferon-alpha production (GO:0032647)2.81420989
158reactive oxygen species biosynthetic process (GO:1903409)2.80948688
159negative regulation of lipid storage (GO:0010888)2.80909053
160regulation of T-helper 2 cell differentiation (GO:0045628)2.80162094
161positive regulation of nitric oxide biosynthetic process (GO:0045429)2.80058819
162hippo signaling (GO:0035329)2.79729844
163heart morphogenesis (GO:0003007)2.79199538
164hydrogen peroxide biosynthetic process (GO:0050665)2.78276694
165cell surface receptor signaling pathway involved in heart development (GO:0061311)2.77855406
166outflow tract septum morphogenesis (GO:0003148)2.77500637
167lysosome organization (GO:0007040)2.76770095
168lytic vacuole organization (GO:0080171)2.76770095
169regulation of interleukin-8 biosynthetic process (GO:0045414)2.76027351
170cell migration involved in heart development (GO:0060973)2.74080800
171regulation of morphogenesis of a branching structure (GO:0060688)2.72958828
172respiratory tube development (GO:0030323)2.72736347
173epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72256381
174positive regulation of cellular amide metabolic process (GO:0034250)2.72187055
175positive regulation of NF-kappaB import into nucleus (GO:0042346)2.71926449
176macrophage activation (GO:0042116)2.71387299
177regulation of apoptotic process involved in morphogenesis (GO:1902337)2.70804035
178embryonic camera-type eye development (GO:0031076)2.70123596
179response to protozoan (GO:0001562)2.68108023
180vitamin D metabolic process (GO:0042359)2.67569062
181mammary gland epithelial cell differentiation (GO:0060644)2.66943829
182embryonic limb morphogenesis (GO:0030326)2.66780395
183embryonic appendage morphogenesis (GO:0035113)2.66780395
184decidualization (GO:0046697)2.66710360
185positive regulation of hormone biosynthetic process (GO:0046886)2.66349510
186mannose metabolic process (GO:0006013)2.66238085
187myeloid cell activation involved in immune response (GO:0002275)2.66136968
188negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.65398069
189positive regulation of interleukin-6 production (GO:0032755)2.65159320
190positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64618295
191protein localization to endosome (GO:0036010)2.64430646
192pattern specification involved in kidney development (GO:0061004)2.62966435
193metanephric mesenchyme development (GO:0072075)2.62395956
194hair follicle morphogenesis (GO:0031069)2.62288185
195embryonic skeletal joint morphogenesis (GO:0060272)2.61269652
196negative regulation of osteoblast proliferation (GO:0033689)2.60551338
197establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59415150
198mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.59113938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.52083358
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.53383435
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.34005888
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.84880422
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.67769950
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.57955978
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.56974931
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.40437628
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.36882214
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.31765018
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.98649830
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.94104068
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.77596102
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74865571
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.69036931
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55192978
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55192978
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.48765736
19VDR_21846776_ChIP-Seq_THP-1_Human2.48550050
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47020732
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46243566
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41536786
23* VDR_24763502_ChIP-Seq_THP-1_Human2.33595150
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.28830154
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28204333
26JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26914525
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.21337953
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.17719902
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17406714
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.15818158
31* LXR_22292898_ChIP-Seq_THP-1_Human2.15364535
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13880228
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12162253
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09507353
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08378871
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06904340
37* VDR_24787735_ChIP-Seq_THP-1_Human2.06552559
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06228354
39* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.06192380
40TP53_20018659_ChIP-ChIP_R1E_Mouse2.01418368
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97688846
42SPI1_23127762_ChIP-Seq_K562_Human1.91037658
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.89873100
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88919270
45* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84757246
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81495630
47SCL_19346495_ChIP-Seq_HPC-7_Human1.81283651
48AR_21572438_ChIP-Seq_LNCaP_Human1.80753000
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79575902
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79511848
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74569377
52RING1B_27294783_Chip-Seq_NPCs_Mouse1.73053650
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.72136973
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69497285
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69379592
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67438022
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67438022
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67438022
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66255542
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66238270
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65633232
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.64061528
63* EZH2_27294783_Chip-Seq_ESCs_Mouse1.62959179
64* ELK3_25401928_ChIP-Seq_HUVEC_Human1.61993823
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57226940
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55950309
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55137237
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54218933
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53880903
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53595394
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53434324
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51447166
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.51185325
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50548008
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47348961
76SPI1_23547873_ChIP-Seq_NB4_Human1.47283054
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46865358
78KDM2B_26808549_Chip-Seq_DND41_Human1.45836648
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45107137
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.43824104
81* DROSHA_22980978_ChIP-Seq_HELA_Human1.43499288
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43406839
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43394288
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43291014
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43106702
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.43106131
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42079767
88AHR_22903824_ChIP-Seq_MCF-7_Human1.40535953
89GBX2_23144817_ChIP-Seq_PC3_Human1.40534414
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39809480
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38548524
92* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37549665
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36513449
94EZH2_22144423_ChIP-Seq_EOC_Human1.35547689
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33999938
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.33129360
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32558543
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32542693
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32346102
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.30802355
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.30354529
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30247515
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29101408
104* PU_27001747_Chip-Seq_BMDM_Mouse1.28615423
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26961398
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26626204
107GATA1_19941827_ChIP-Seq_MEL_Mouse1.25407637
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23816727
109* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23681967
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23330144
111STAT1_20625510_ChIP-Seq_HELA_Human1.21984807
112KDM2B_26808549_Chip-Seq_K562_Human1.21948730
113TFEB_21752829_ChIP-Seq_HELA_Human1.21776235
114TP53_16413492_ChIP-PET_HCT116_Human1.21551472
115SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21435131
116* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20537833
117* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20536074
118CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18853147
119EGR1_19032775_ChIP-ChIP_M12_Human1.17866841
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17675003
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17448409
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17407090
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16775083
124SALL1_21062744_ChIP-ChIP_HESCs_Human1.15493430
125ARNT_22903824_ChIP-Seq_MCF-7_Human1.15252677
126TP53_18474530_ChIP-ChIP_U2OS_Human1.14174873
127RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14090633
128TCF7_22412390_ChIP-Seq_EML_Mouse1.14088800
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.13226580
130CLOCK_20551151_ChIP-Seq_293T_Human1.13090542
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11687162
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11156287
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10586320
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09448795
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09214467
136* GATA1_19941826_ChIP-Seq_K562_Human1.08137612
137ESR2_21235772_ChIP-Seq_MCF-7_Human1.07316010
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07287383
139PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07074173
140* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06904536
141PIAS1_25552417_ChIP-Seq_VCAP_Human1.06450992
142WT1_19549856_ChIP-ChIP_CCG9911_Human1.06044421
143* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04190156
144TCF4_18268006_ChIP-ChIP_LS174T_Human1.04070297
145* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03648115
146KDM2B_26808549_Chip-Seq_JURKAT_Human1.03007301
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02869915
148KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02738270
149RACK7_27058665_Chip-Seq_MCF-7_Human1.02083670
150* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01462597
151CJUN_26792858_Chip-Seq_BT549_Human1.00877125
152MYC_22102868_ChIP-Seq_BL_Human1.00548385
153CDX2_20551321_ChIP-Seq_CACO-2_Human1.00175191
154* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99953671
155* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99032528
156BCOR_27268052_Chip-Seq_Bcells_Human0.98730946
157VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98640217
158MAF_26560356_Chip-Seq_TH1_Human0.97800448
159* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97574962
160ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97567154
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96651953
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95442424
163HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95002785
164ESR1_20079471_ChIP-ChIP_T-47D_Human0.94320637
165BCL6_27268052_Chip-Seq_Bcells_Human0.93914536
166* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93627574
167* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92959364
168RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92919040
169SA1_27219007_Chip-Seq_ERYTHROID_Human0.92882566
170* SMAD4_21799915_ChIP-Seq_A2780_Human0.92129314
171NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91959666
172* AR_19668381_ChIP-Seq_PC3_Human0.90830919
173RXR_22158963_ChIP-Seq_LIVER_Mouse0.89946707
174TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89668303
175RXR_22108803_ChIP-Seq_LS180_Human0.89569858
176OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88647257
177SA1_27219007_Chip-Seq_Bcells_Human0.85421360
178DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83452996
179UTX_26944678_Chip-Seq_JUKART_Human0.83236268
180GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81936664
181PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81614057
182ELF1_20517297_ChIP-Seq_JURKAT_Human0.80838809
183CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80285369
184ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79952563
185* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79111989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.62735253
2MP0003303_peritoneal_inflammation4.96551708
3MP0010030_abnormal_orbit_morphology4.64956551
4MP0006082_CNS_inflammation3.59875417
5MP0005503_abnormal_tendon_morphology3.49747633
6MP0010368_abnormal_lymphatic_system3.24927926
7MP0002148_abnormal_hypersensitivity_rea3.16747888
8MP0000566_synostosis3.10345677
9MP0009840_abnormal_foam_cell3.03831459
10MP0004510_myositis2.99591144
11MP0003436_decreased_susceptibility_to2.93339054
12MP0003172_abnormal_lysosome_physiology2.90428895
13MP0002139_abnormal_hepatobiliary_system2.87364612
14MP0000537_abnormal_urethra_morphology2.84829791
15MP0002938_white_spotting2.84218441
16MP0003385_abnormal_body_wall2.83954725
17MP0003122_maternal_imprinting2.73105539
18MP0000343_altered_response_to2.70860892
19MP0004272_abnormal_basement_membrane2.70755684
20MP0009785_altered_susceptibility_to2.69420348
21MP0009250_abnormal_appendicular_skeleto2.62325777
22MP0005248_abnormal_Harderian_gland2.57170853
23MP0000604_amyloidosis2.50938705
24MP0000762_abnormal_tongue_morphology2.50168749
25MP0002419_abnormal_innate_immunity2.49323857
26MP0002837_dystrophic_cardiac_calcinosis2.46991697
27MP0005275_abnormal_skin_tensile2.45567434
28MP0008004_abnormal_stomach_pH2.45344305
29MP0002254_reproductive_system_inflammat2.44224841
30MP0005671_abnormal_response_to2.34602255
31MP0003075_altered_response_to2.34508885
32MP0008438_abnormal_cutaneous_collagen2.33990134
33MP0003724_increased_susceptibility_to2.29530554
34MP0001346_abnormal_lacrimal_gland2.29231514
35MP0003942_abnormal_urinary_system2.20812003
36MP0005000_abnormal_immune_tolerance2.17969229
37MP0005187_abnormal_penis_morphology2.17103961
38MP0000428_abnormal_craniofacial_morphol2.15868296
39MP0003300_gastrointestinal_ulcer2.12613701
40MP0000534_abnormal_ureter_morphology2.07932405
41MP0001299_abnormal_eye_distance/2.05975534
42MP0000049_abnormal_middle_ear2.05727727
43MP0001790_abnormal_immune_system2.05476121
44MP0005387_immune_system_phenotype2.05476121
45MP0001835_abnormal_antigen_presentation2.04203421
46MP0005025_abnormal_response_to2.03385801
47MP0003941_abnormal_skin_development1.99550610
48MP0009764_decreased_sensitivity_to1.99376435
49MP0009053_abnormal_anal_canal1.98626877
50MP0001533_abnormal_skeleton_physiology1.98108708
51MP0002249_abnormal_larynx_morphology1.95655888
52MP0003690_abnormal_glial_cell1.94467456
53MP0001853_heart_inflammation1.94200846
54MP0005167_abnormal_blood-brain_barrier1.91203929
55MP0002998_abnormal_bone_remodeling1.90043015
56MP0002282_abnormal_trachea_morphology1.85662195
57MP0003755_abnormal_palate_morphology1.74816644
58MP0003937_abnormal_limbs/digits/tail_de1.73271421
59MP0002452_abnormal_antigen_presenting1.71427950
60MP0005508_abnormal_skeleton_morphology1.69434668
61MP0001879_abnormal_lymphatic_vessel1.67962097
62MP0003453_abnormal_keratinocyte_physiol1.67067590
63MP0002108_abnormal_muscle_morphology1.65634147
64MP0003935_abnormal_craniofacial_develop1.65273935
65MP0003938_abnormal_ear_development1.63327102
66MP0002932_abnormal_joint_morphology1.62523971
67MP0001293_anophthalmia1.62486252
68MP0002723_abnormal_immune_serum1.62070775
69MP0004134_abnormal_chest_morphology1.60206513
70MP0003879_abnormal_hair_cell1.59397992
71MP0000579_abnormal_nail_morphology1.59233187
72MP0003115_abnormal_respiratory_system1.57949408
73MP0003329_amyloid_beta_deposits1.55460152
74MP0005397_hematopoietic_system_phenotyp1.55254698
75MP0001545_abnormal_hematopoietic_system1.55254698
76MP0000920_abnormal_myelination1.54090967
77MP0002116_abnormal_craniofacial_bone1.53675085
78MP0002138_abnormal_hepatobiliary_system1.50467736
79MP0003191_abnormal_cellular_cholesterol1.48077130
80MP0001845_abnormal_inflammatory_respons1.46124680
81MP0005257_abnormal_intraocular_pressure1.44181637
82MP0004947_skin_inflammation1.40379103
83MP0005623_abnormal_meninges_morphology1.40086524
84MP0006072_abnormal_retinal_apoptosis1.39954677
85MP0008469_abnormal_protein_level1.39897456
86MP0000462_abnormal_digestive_system1.39042400
87MP0000685_abnormal_immune_system1.38963102
88MP0003705_abnormal_hypodermis_morpholog1.38550524
89MP0008789_abnormal_olfactory_epithelium1.38211358
90MP0005451_abnormal_body_composition1.37725653
91MP0003448_altered_tumor_morphology1.34672095
92MP0001501_abnormal_sleep_pattern1.34005704
93MP0001800_abnormal_humoral_immune1.33739640
94MP0002405_respiratory_system_inflammati1.33381311
95MP0005310_abnormal_salivary_gland1.33316226
96MP0006054_spinal_hemorrhage1.32706331
97MP0003195_calcinosis1.32472849
98MP0005367_renal/urinary_system_phenotyp1.30492890
99MP0000516_abnormal_urinary_system1.30492890
100MP0001819_abnormal_immune_cell1.30085088
101MP0002420_abnormal_adaptive_immunity1.29588566
102MP0002233_abnormal_nose_morphology1.29282646
103MP0003183_abnormal_peptide_metabolism1.29098884
104MP0002177_abnormal_outer_ear1.29079529
105MP0002102_abnormal_ear_morphology1.24924565
106MP0001340_abnormal_eyelid_morphology1.21866385
107MP0000647_abnormal_sebaceous_gland1.21143082
108MP0002109_abnormal_limb_morphology1.21022504
109MP0003634_abnormal_glial_cell1.20690674
110MP0004233_abnormal_muscle_weight1.20356852
111MP0003119_abnormal_digestive_system1.18398954
112MP0003123_paternal_imprinting1.18233210
113MP0000163_abnormal_cartilage_morphology1.15374228
114MP0000858_altered_metastatic_potential1.15218245
115MP0000432_abnormal_head_morphology1.13053077
116MP0010155_abnormal_intestine_physiology1.11695200
117MP0001958_emphysema1.10721840
118MP0000383_abnormal_hair_follicle1.09010610
119MP0005166_decreased_susceptibility_to1.07733366
120MP0002089_abnormal_postnatal_growth/wei1.07518579
121MP0003828_pulmonary_edema1.05573049
122MP0000733_abnormal_muscle_development1.04478388
123MP0002098_abnormal_vibrissa_morphology1.03925510
124MP0000613_abnormal_salivary_gland1.03619866
125MP0005499_abnormal_olfactory_system1.02747520
126MP0005394_taste/olfaction_phenotype1.02747520
127MP0005464_abnormal_platelet_physiology1.02489629
128MP0001270_distended_abdomen1.01515308
129MP0005165_increased_susceptibility_to1.00606151
130MP0000751_myopathy0.99605538
131MP0001177_atelectasis0.98698512
132MP0003121_genomic_imprinting0.97618033
133MP0002115_abnormal_skeleton_extremities0.95384898
134MP0005390_skeleton_phenotype0.94739544
135MP0002332_abnormal_exercise_endurance0.93146164
136MP0002751_abnormal_autonomic_nervous0.92509085
137MP0002114_abnormal_axial_skeleton0.92003761
138MP0002111_abnormal_tail_morphology0.91376404
139MP0002697_abnormal_eye_size0.91177304
140MP0003279_aneurysm0.90744471
141MP0000467_abnormal_esophagus_morphology0.89829637
142MP0003806_abnormal_nucleotide_metabolis0.89709054
143MP0002060_abnormal_skin_morphology0.89654625
144MP0010307_abnormal_tumor_latency0.88772537
145MP0002295_abnormal_pulmonary_circulatio0.88040111
146MP0005595_abnormal_vascular_smooth0.87564291
147MP0002092_abnormal_eye_morphology0.87508432
148MP0002132_abnormal_respiratory_system0.87496323
149MP0005365_abnormal_bile_salt0.86556590
150MP0005391_vision/eye_phenotype0.86174961
151MP0001243_abnormal_dermal_layer0.85988624
152MP0003136_yellow_coat_color0.85985780
153MP0009333_abnormal_splenocyte_physiolog0.85501255
154MP0005377_hearing/vestibular/ear_phenot0.84760375
155MP0003878_abnormal_ear_physiology0.84760375
156MP0003283_abnormal_digestive_organ0.84034520
157MP0000716_abnormal_immune_system0.82673088
158MP0003656_abnormal_erythrocyte_physiolo0.82002952
159MP0001542_abnormal_bone_strength0.81878231
160MP0001849_ear_inflammation0.81059936
161MP0002925_abnormal_cardiovascular_devel0.77586708
162MP0001663_abnormal_digestive_system0.77465693
163MP0002896_abnormal_bone_mineralization0.77427166
164MP0000778_abnormal_nervous_system0.77255763
165MP0005076_abnormal_cell_differentiation0.77183394
166MP0005171_absent_coat_pigmentation0.76961220
167MP0001286_abnormal_eye_development0.76149209
168MP0000631_abnormal_neuroendocrine_gland0.75663726
169MP0005253_abnormal_eye_physiology0.75520361
170MP0003646_muscle_fatigue0.75213746
171MP0003795_abnormal_bone_structure0.75069454
172MP0005551_abnormal_eye_electrophysiolog0.74998808
173MP0009278_abnormal_bone_marrow0.73502717
174MP0005023_abnormal_wound_healing0.73357183
175MP0002113_abnormal_skeleton_development0.72282499
176MP0009763_increased_sensitivity_to0.71801223
177MP0000678_abnormal_parathyroid_gland0.71770342
178MP0002234_abnormal_pharynx_morphology0.71493823
179MP0002277_abnormal_respiratory_mucosa0.71320604
180MP0010678_abnormal_skin_adnexa0.69230618
181MP0004742_abnormal_vestibular_system0.67908364
182MP0002090_abnormal_vision0.67082859
183MP0008260_abnormal_autophagy0.64603953
184MP0000681_abnormal_thyroid_gland0.64561991
185MP0003186_abnormal_redox_activity0.63435596
186MP0005647_abnormal_sex_gland0.61947923
187MP0002933_joint_inflammation0.61850896
188MP0003633_abnormal_nervous_system0.61798902
189MP0003137_abnormal_impulse_conducting0.60810068
190MP0008874_decreased_physiological_sensi0.59002413
191MP0002429_abnormal_blood_cell0.58560820
192MP0003632_abnormal_nervous_system0.58307286
193MP0000689_abnormal_spleen_morphology0.57670154
194MP0000747_muscle_weakness0.57093927
195MP0005164_abnormal_response_to0.56667793

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)8.84189980
2Abnormality of liposaccharide metabolism (HP:0010968)8.84189980
3Abnormality of glycosphingolipid metabolism (HP:0004343)8.84189980
4Vacuolated lymphocytes (HP:0001922)6.67166963
5Increased cerebral lipofuscin (HP:0011813)6.40076976
6Nuclear cataract (HP:0100018)5.84943728
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.69555667
8Short 4th metacarpal (HP:0010044)5.69555667
9Systemic lupus erythematosus (HP:0002725)5.51831873
10Dysostosis multiplex (HP:0000943)5.49099042
11Disinhibition (HP:0000734)5.44936307
12Increased neuronal autofluorescent lipopigment (HP:0002074)5.34953944
13Abnormality of the parietal bone (HP:0002696)5.23649606
14Loss of speech (HP:0002371)5.05135075
15Midline defect of the nose (HP:0004122)5.04463002
16Mutism (HP:0002300)4.85811300
17Neurofibrillary tangles (HP:0002185)4.39187592
18Axonal loss (HP:0003447)4.26119837
19Abnormality of the 4th metacarpal (HP:0010012)4.24894285
20Broad metatarsal (HP:0001783)4.17938696
21Abnormality of macrophages (HP:0004311)4.13616389
22Abnormality of the vasculature of the conjunctiva (HP:0008054)3.90635941
23Abnormality of polysaccharide metabolism (HP:0011012)3.86235148
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.86235148
25Abnormality of mucopolysaccharide metabolism (HP:0011020)3.86235148
26Glomerulonephritis (HP:0000099)3.84573021
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.83885313
28Shallow orbits (HP:0000586)3.82814539
29Trigonocephaly (HP:0000243)3.72764341
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.69842100
31Mucopolysacchariduria (HP:0008155)3.61603047
32Urinary glycosaminoglycan excretion (HP:0003541)3.61603047
33Aplasia involving bones of the extremities (HP:0009825)3.57921205
34Aplasia involving bones of the upper limbs (HP:0009823)3.57921205
35Aplasia of the phalanges of the hand (HP:0009802)3.57921205
36Agnosia (HP:0010524)3.57237377
37Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.49483333
38Recurrent abscess formation (HP:0002722)3.40141976
39Autoimmune thrombocytopenia (HP:0001973)3.32352621
40Apathy (HP:0000741)3.31606208
41Nasolacrimal duct obstruction (HP:0000579)3.31523391
42Neoplasm of the heart (HP:0100544)3.29730044
43Recurrent bacterial skin infections (HP:0005406)3.29616687
44Diminished motivation (HP:0000745)3.19493571
45Broad toe (HP:0001837)3.12304511
46Inappropriate behavior (HP:0000719)3.07089615
47Anteriorly placed anus (HP:0001545)3.06503223
48Retrobulbar optic neuritis (HP:0100654)3.03146119
49Optic neuritis (HP:0100653)3.03146119
50Hematochezia (HP:0002573)3.02617161
51Orchitis (HP:0100796)3.02302290
52Turricephaly (HP:0000262)3.01029330
53Abnormality of the nasolacrimal system (HP:0000614)3.00014681
54Broad hallux (HP:0010055)2.98876797
55Coronal craniosynostosis (HP:0004440)2.97846548
56Abnormality of the lacrimal duct (HP:0011481)2.95308260
57Alacrima (HP:0000522)2.93472949
58Cerebral inclusion bodies (HP:0100314)2.93331872
59Mediastinal lymphadenopathy (HP:0100721)2.90149830
60Retinal atrophy (HP:0001105)2.87257142
61Abnormality of the nasal septum (HP:0000419)2.86351185
62Complement deficiency (HP:0004431)2.86048670
63Abnormality of the distal phalanx of the thumb (HP:0009617)2.81120030
64Neuronal loss in central nervous system (HP:0002529)2.79500826
65Purpura (HP:0000979)2.79162074
66Eczematoid dermatitis (HP:0000976)2.77653899
67Down-sloping shoulders (HP:0200021)2.75007004
68Asymmetric septal hypertrophy (HP:0001670)2.72891321
69Partial duplication of the phalanx of hand (HP:0009999)2.70966111
70Upper motor neuron abnormality (HP:0002127)2.70629879
71Follicular hyperkeratosis (HP:0007502)2.70529260
72Myositis (HP:0100614)2.66349249
73Metaphyseal irregularity (HP:0003025)2.64266208
74Short phalanx of the thumb (HP:0009660)2.62889589
75Stomatitis (HP:0010280)2.61946279
76Milia (HP:0001056)2.61623581
77Personality changes (HP:0000751)2.61121114
78Abnormal number of incisors (HP:0011064)2.58978649
79Synostosis involving the elbow (HP:0003938)2.58191487
80Humeroradial synostosis (HP:0003041)2.58191487
81Abnormality of the diencephalon (HP:0010662)2.56816035
82Increased serum ferritin (HP:0003281)2.56397822
83Ankle contracture (HP:0006466)2.55142816
84Amyloidosis (HP:0011034)2.53528567
85Progressive neurologic deterioration (HP:0002344)2.51428344
86Renal duplication (HP:0000075)2.50668253
87Mesomelia (HP:0003027)2.49575446
88Recurrent gram-negative bacterial infections (HP:0005420)2.47303262
89Abnormality of the phalanges of the 2nd finger (HP:0009541)2.47066981
90Supernumerary ribs (HP:0005815)2.46921412
91Dementia (HP:0000726)2.44075956
92Conjunctival telangiectasia (HP:0000524)2.34439068
93Peripheral demyelination (HP:0011096)2.32103267
94Chorioretinal atrophy (HP:0000533)2.30162159
95Cutaneous finger syndactyly (HP:0010554)2.29030802
96Type 1 muscle fiber predominance (HP:0003803)2.28054169
97Thoracic kyphosis (HP:0002942)2.27549934
98Hepatosplenomegaly (HP:0001433)2.26516631
99Abnormality of the incisor (HP:0000676)2.26069669
100Abnormality of incisor morphology (HP:0011063)2.25634278
101Asymmetry of the thorax (HP:0001555)2.24778292
102Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24405675
103Decreased lacrimation (HP:0000633)2.23465304
104Anophthalmia (HP:0000528)2.22182146
105Nausea (HP:0002018)2.22145002
106Microglossia (HP:0000171)2.22090584
107Basal ganglia calcification (HP:0002135)2.21495152
108Myocardial infarction (HP:0001658)2.19809344
109Concave nail (HP:0001598)2.18611726
110Atrophic scars (HP:0001075)2.18308113
111Zonular cataract (HP:0010920)2.18079311
112Partial duplication of thumb phalanx (HP:0009944)2.17238525
113Supernumerary bones of the axial skeleton (HP:0009144)2.14853226
114Abnormality of complement system (HP:0005339)2.14152674
115Protrusio acetabuli (HP:0003179)2.13065677
116Preaxial foot polydactyly (HP:0001841)2.12396038
117Deviation of the hallux (HP:0010051)2.12231904
118Narrow nasal bridge (HP:0000446)2.11595949
119Petechiae (HP:0000967)2.09500677
120Pathologic fracture (HP:0002756)2.08286325
121Prolonged neonatal jaundice (HP:0006579)2.06866834
122Chronic obstructive pulmonary disease (HP:0006510)2.06560079
123Obstructive lung disease (HP:0006536)2.06560079
124Premature rupture of membranes (HP:0001788)2.05503897
125Aplasia cutis congenita (HP:0001057)2.05389831
126Hypoplastic labia majora (HP:0000059)2.05084725
127Polyneuropathy (HP:0001271)2.04997682
128Vitreoretinal degeneration (HP:0000655)2.04984667
129Supranuclear gaze palsy (HP:0000605)2.04858038
130Abnormality of the 2nd finger (HP:0004100)2.04262643
131Progressive visual loss (HP:0000529)2.03591431
132Aortic dissection (HP:0002647)2.02862317
133Cutaneous syndactyly (HP:0012725)2.02827428
134Spontaneous hematomas (HP:0007420)2.01711597
135Short hallux (HP:0010109)2.01651227
136Abnormality of the middle phalanges of the hand (HP:0009833)2.01232166
137Abnormality of the middle phalanges of the toes (HP:0010183)2.00804488
138Narrow palate (HP:0000189)1.99004351
139Aqueductal stenosis (HP:0002410)1.98042331
140Keratoconjunctivitis sicca (HP:0001097)1.97460354
141Segmental peripheral demyelination/remyelination (HP:0003481)1.95868038
142Cerebral aneurysm (HP:0004944)1.95722492
143Cardiomegaly (HP:0001640)1.95617778
144Buphthalmos (HP:0000557)1.95181962
145Hallux valgus (HP:0001822)1.95033914
146Memory impairment (HP:0002354)1.94721632
147Bone pain (HP:0002653)1.93229665
148Bronchomalacia (HP:0002780)1.92461189
149Stomach cancer (HP:0012126)1.91923994
150Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.91725941
151Bladder diverticulum (HP:0000015)1.90025301
152Pulmonary infiltrates (HP:0002113)1.90006426
153Hypoventilation (HP:0002791)1.89652941
154Short metatarsal (HP:0010743)1.88638850
155Hemoptysis (HP:0002105)1.88626505
156Hypoplasia of the maxilla (HP:0000327)1.88520899
157Nephritis (HP:0000123)1.87705404
158Exostoses (HP:0100777)1.86772800
159Recurrent corneal erosions (HP:0000495)1.86378739
160Abnormality of iron homeostasis (HP:0011031)1.85827065
161Protruding ear (HP:0000411)1.85106092
162Bell-shaped thorax (HP:0001591)1.84816046
163Abnormality of the lumbar spine (HP:0100712)1.84135220
164Abnormality of the labia majora (HP:0012881)1.83847191
165Abnormality of lateral ventricle (HP:0030047)1.83642189
166Mesangial abnormality (HP:0001966)1.81630800
167Bilateral microphthalmos (HP:0007633)1.81624340
168Wide anterior fontanel (HP:0000260)1.79874454
169Congenital stationary night blindness (HP:0007642)1.78588327
170Choanal stenosis (HP:0000452)1.76673463
171Broad thumb (HP:0011304)1.76098346
172Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.75927611
173Keratoconjunctivitis (HP:0001096)1.75409845
174Fragile skin (HP:0001030)1.74983629
175Slender build (HP:0001533)1.74521753
176Overriding aorta (HP:0002623)1.74472299
177Ulnar bowing (HP:0003031)1.74131303
178Aplasia/Hypoplasia of the hallux (HP:0008362)1.74029931
179Increased number of teeth (HP:0011069)1.73320780
180Overgrowth (HP:0001548)1.73251641
181Large earlobe (HP:0009748)1.73245824
182Abnormality of the humeroradial joint (HP:0100744)1.72816801
183Short middle phalanx of finger (HP:0005819)1.71834929
184Vertigo (HP:0002321)1.71369924
185Sensorimotor neuropathy (HP:0007141)1.70706251
186Sparse lateral eyebrow (HP:0005338)1.70231166
187Multiple enchondromatosis (HP:0005701)1.68443155
188Aortic aneurysm (HP:0004942)1.67327717
189Esophageal varix (HP:0002040)1.66771345
190Poor head control (HP:0002421)1.64828246
191Abnormality of the basal ganglia (HP:0002134)1.62183226
192Vertebral compression fractures (HP:0002953)1.62179009
193Acrocyanosis (HP:0001063)1.59101730
194Abnormality of the periventricular white matter (HP:0002518)1.58216438
195Beaking of vertebral bodies (HP:0004568)1.58133240
196Global brain atrophy (HP:0002283)1.57545032
197Urinary incontinence (HP:0000020)1.56483217
198Recurrent skin infections (HP:0001581)1.56183915
199Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.55490460
200Protuberant abdomen (HP:0001538)1.54780527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR24.48161209
2IRAK34.39875395
3DDR24.02793348
4NME24.02602462
5EPHB23.84926235
6GRK73.69661180
7PDGFRA3.03178722
8MAP3K143.02836785
9RIPK13.01402821
10LATS12.96323211
11TBK12.42765268
12BLK2.37751482
13ACVR1B2.37657761
14DMPK2.37161442
15LATS22.28532545
16MAPK152.07969708
17SIK11.95824033
18ICK1.90458814
19IKBKB1.88604975
20FGFR11.86840481
21EPHA31.79675651
22MOS1.78177153
23MAP2K61.75509621
24TIE11.72135454
25BMX1.66477118
26CAMK1G1.64999364
27TAOK21.63026837
28PIM21.59693976
29IRAK41.54594617
30TTN1.50747451
31FER1.46406298
32ADRBK21.46350774
33CSK1.45868862
34RIPK41.44895205
35PDGFRB1.44469569
36TYK21.44201255
37CSF1R1.42512309
38AKT31.39181567
39IKBKE1.37564399
40TGFBR21.34846741
41CAMK1D1.28865504
42ABL21.28360264
43PTK21.26345348
44KIT1.23673692
45MAP3K101.22285866
46PAK21.20577941
47MAP3K131.11471608
48MAP2K31.09455939
49PHKG21.06701152
50PHKG11.06701152
51ERBB21.01540542
52TRIB30.98951064
53CLK10.98334052
54ERN10.98311288
55CDK120.97818402
56TGFBR10.97616954
57LYN0.97508614
58MYLK0.97272923
59CHUK0.97092369
60WNK10.96406806
61PDK20.95992225
62ROCK10.95502541
63IRAK20.95124275
64TXK0.92777981
65FES0.92773685
66CDC42BPA0.92450151
67TYRO30.91675407
68HIPK20.90531434
69MAP4K10.88300076
70ZAP700.85267067
71JAK30.85153968
72ERBB30.83908420
73MTOR0.83562649
74KSR10.81088684
75ARAF0.80891456
76CAMK40.77309642
77PRKD20.75794327
78PTK60.75753013
79GSK3A0.74537752
80MAP3K10.74494254
81PRPF4B0.74150620
82CDK60.73630951
83PAK30.73444993
84MAP3K60.73433968
85UHMK10.71233560
86BMPR20.71085835
87TESK20.70879297
88SYK0.70445550
89NTRK20.67015762
90MAP3K50.66912711
91ADRBK10.66570720
92MARK30.65409746
93PAK60.65349771
94MAP3K70.63602219
95MAP2K20.63245790
96SGK30.62836155
97STK30.61997960
98PTK2B0.61806285
99PRKD10.61681615
100PKN10.61168604
101MARK20.59863863
102CAMKK20.59550823
103GRK10.59238101
104NLK0.58097604
105DYRK1B0.57817943
106TAOK10.57565948
107MAPK10.56974824
108ERBB40.56619975
109RPS6KC10.56357654
110RPS6KL10.56357654
111ZAK0.56063918
112PRKCH0.55791915
113MET0.55595279
114STK100.55107638
115ROCK20.54703052
116CDK40.54641890
117RPS6KA20.54337227
118MAPK40.54113771
119LCK0.53741226
120LMTK20.53668829
121NTRK10.51267221
122DAPK20.49196824
123STK380.48855900
124PRKCE0.48702626
125LRRK20.46918668
126JAK10.45771882
127JAK20.45060197
128SGK20.44673363
129MAPK70.42927346
130BCKDK0.42814839
131PIK3CA0.42228121
132CAMK10.40305744
133PDPK10.39408596
134CDK70.39055100
135MAP3K30.38828756
136PIM10.38747015
137CSNK1A1L0.38388576
138SRC0.38344900
139DYRK30.38119179
140BRD40.37730413
141MAPK30.36747853
142HCK0.36119013
143NEK90.35904088
144PAK40.35672375
145MAPK80.35653578
146MAPK100.35646597
147RPS6KA60.35610449
148MAP3K110.35533813
149INSR0.34653482
150RPS6KA10.34218425
151SGK2230.34168716
152SGK4940.34168716
153MATK0.34138981
154MAPK140.33518138
155FGR0.31862106
156CDK30.31554139
157MAPK120.30473633
158TESK10.29789622
159MAP3K80.28979429
160ABL10.28819533
161IRAK10.27349797
162DAPK30.27338456
163BRAF0.27109404
164SIK30.26716935

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005115.10990609
2Basal cell carcinoma_Homo sapiens_hsa052174.28507354
3Hedgehog signaling pathway_Homo sapiens_hsa043403.91693420
4Lysosome_Homo sapiens_hsa041423.90351121
5Rheumatoid arthritis_Homo sapiens_hsa053233.09573064
6Staphylococcus aureus infection_Homo sapiens_hsa051502.80327602
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.77210164
8Osteoclast differentiation_Homo sapiens_hsa043802.70672509
9Asthma_Homo sapiens_hsa053102.56585424
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.54883336
11ECM-receptor interaction_Homo sapiens_hsa045122.51794628
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.51185380
13Malaria_Homo sapiens_hsa051442.33299016
14Hippo signaling pathway_Homo sapiens_hsa043902.33151577
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32430846
16Leishmaniasis_Homo sapiens_hsa051402.25326922
17Pertussis_Homo sapiens_hsa051332.08360135
18Wnt signaling pathway_Homo sapiens_hsa043102.06652263
19Adherens junction_Homo sapiens_hsa045202.02635659
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00029112
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.97633058
22Tuberculosis_Homo sapiens_hsa051521.96061519
23TNF signaling pathway_Homo sapiens_hsa046681.94117711
24Protein digestion and absorption_Homo sapiens_hsa049741.90378860
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89793736
26Allograft rejection_Homo sapiens_hsa053301.86259460
27Autoimmune thyroid disease_Homo sapiens_hsa053201.80250556
28Proteoglycans in cancer_Homo sapiens_hsa052051.80227890
29Axon guidance_Homo sapiens_hsa043601.77069213
30Focal adhesion_Homo sapiens_hsa045101.74454598
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.73617812
32TGF-beta signaling pathway_Homo sapiens_hsa043501.73214624
33Legionellosis_Homo sapiens_hsa051341.70395604
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.67209285
35Notch signaling pathway_Homo sapiens_hsa043301.66842847
36Salmonella infection_Homo sapiens_hsa051321.64903269
37Prion diseases_Homo sapiens_hsa050201.61771818
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61505708
39Graft-versus-host disease_Homo sapiens_hsa053321.60933283
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.60751876
41Dilated cardiomyopathy_Homo sapiens_hsa054141.59762107
42Melanogenesis_Homo sapiens_hsa049161.58210246
43Collecting duct acid secretion_Homo sapiens_hsa049661.57878593
44Antigen processing and presentation_Homo sapiens_hsa046121.52922132
45Phagosome_Homo sapiens_hsa041451.50164041
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49737912
47Pathways in cancer_Homo sapiens_hsa052001.48971283
48Renin secretion_Homo sapiens_hsa049241.47103965
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44224128
50Melanoma_Homo sapiens_hsa052181.41626925
51Prostate cancer_Homo sapiens_hsa052151.39881522
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.36616429
53Phototransduction_Homo sapiens_hsa047441.36419828
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.35392528
55Circadian rhythm_Homo sapiens_hsa047101.32570765
56African trypanosomiasis_Homo sapiens_hsa051431.32254744
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30633558
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28648743
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26804155
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25200796
61Colorectal cancer_Homo sapiens_hsa052101.24272087
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.21154166
63Sphingolipid metabolism_Homo sapiens_hsa006001.20262072
64Small cell lung cancer_Homo sapiens_hsa052221.19844005
65Endometrial cancer_Homo sapiens_hsa052131.14602305
66Rap1 signaling pathway_Homo sapiens_hsa040151.12425622
67cAMP signaling pathway_Homo sapiens_hsa040241.12333550
68MicroRNAs in cancer_Homo sapiens_hsa052061.12321141
69Gap junction_Homo sapiens_hsa045401.11049041
70Amoebiasis_Homo sapiens_hsa051461.10697118
71PI3K-Akt signaling pathway_Homo sapiens_hsa041511.09980840
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09125996
73Circadian entrainment_Homo sapiens_hsa047131.08957738
74Influenza A_Homo sapiens_hsa051641.08178007
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06512533
76Hematopoietic cell lineage_Homo sapiens_hsa046401.05428278
77Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04684884
78cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01716658
79Type I diabetes mellitus_Homo sapiens_hsa049400.99677665
80Chronic myeloid leukemia_Homo sapiens_hsa052200.97076796
81Estrogen signaling pathway_Homo sapiens_hsa049150.96608266
82B cell receptor signaling pathway_Homo sapiens_hsa046620.96077489
83Tight junction_Homo sapiens_hsa045300.96011228
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95743797
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95611425
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95538252
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94826206
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91962873
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.90842268
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89401090
91GABAergic synapse_Homo sapiens_hsa047270.89369152
92Cholinergic synapse_Homo sapiens_hsa047250.89028334
93Glioma_Homo sapiens_hsa052140.88824747
94Oxytocin signaling pathway_Homo sapiens_hsa049210.88155445
95Salivary secretion_Homo sapiens_hsa049700.87853928
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.87649975
97GnRH signaling pathway_Homo sapiens_hsa049120.87079232
98Viral myocarditis_Homo sapiens_hsa054160.86120082
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85044781
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84721380
101MAPK signaling pathway_Homo sapiens_hsa040100.84427229
102HTLV-I infection_Homo sapiens_hsa051660.83531103
103Vibrio cholerae infection_Homo sapiens_hsa051100.82091786
104Gastric acid secretion_Homo sapiens_hsa049710.81767169
105ErbB signaling pathway_Homo sapiens_hsa040120.81373808
106Chemokine signaling pathway_Homo sapiens_hsa040620.80543239
107Hepatitis C_Homo sapiens_hsa051600.79334063
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78636034
109Ras signaling pathway_Homo sapiens_hsa040140.78139240
110Galactose metabolism_Homo sapiens_hsa000520.77402537
111Bladder cancer_Homo sapiens_hsa052190.77099621
112Lysine degradation_Homo sapiens_hsa003100.77063271
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74255724
114Morphine addiction_Homo sapiens_hsa050320.73222133
115Cocaine addiction_Homo sapiens_hsa050300.72850562
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72693947
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72636083
118Herpes simplex infection_Homo sapiens_hsa051680.72312592
119Amphetamine addiction_Homo sapiens_hsa050310.72271361
120Long-term depression_Homo sapiens_hsa047300.71195191
121Dorso-ventral axis formation_Homo sapiens_hsa043200.70826034
122Type II diabetes mellitus_Homo sapiens_hsa049300.70219454
123Acute myeloid leukemia_Homo sapiens_hsa052210.68891520
124Apoptosis_Homo sapiens_hsa042100.67230498
125Complement and coagulation cascades_Homo sapiens_hsa046100.67026979
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66361943
127Choline metabolism in cancer_Homo sapiens_hsa052310.66073156
128Insulin secretion_Homo sapiens_hsa049110.65413750
129Thyroid cancer_Homo sapiens_hsa052160.65410869
130Glutamatergic synapse_Homo sapiens_hsa047240.64457710
131Nicotine addiction_Homo sapiens_hsa050330.63716440
132Renal cell carcinoma_Homo sapiens_hsa052110.63191014
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.63159288
134Olfactory transduction_Homo sapiens_hsa047400.63125582
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62691396
136Hepatitis B_Homo sapiens_hsa051610.61726854
137Calcium signaling pathway_Homo sapiens_hsa040200.61184736
138Ovarian steroidogenesis_Homo sapiens_hsa049130.61103864
139Tryptophan metabolism_Homo sapiens_hsa003800.60841121
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.59610228
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59426557
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59339377
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.58867553
144Shigellosis_Homo sapiens_hsa051310.58409955
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.57923086
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.57868930
147VEGF signaling pathway_Homo sapiens_hsa043700.57060009
148Platelet activation_Homo sapiens_hsa046110.56653510
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55782799
150mTOR signaling pathway_Homo sapiens_hsa041500.54875158
151Thyroid hormone synthesis_Homo sapiens_hsa049180.54234871
152Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52897234
153Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52340543
154Fructose and mannose metabolism_Homo sapiens_hsa000510.51248939
155Renin-angiotensin system_Homo sapiens_hsa046140.51222306
156Dopaminergic synapse_Homo sapiens_hsa047280.51025749
157Measles_Homo sapiens_hsa051620.47500126
158Insulin signaling pathway_Homo sapiens_hsa049100.47197433
159Mineral absorption_Homo sapiens_hsa049780.46429490
160Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46292164
161HIF-1 signaling pathway_Homo sapiens_hsa040660.44917021
162AMPK signaling pathway_Homo sapiens_hsa041520.43804315
163T cell receptor signaling pathway_Homo sapiens_hsa046600.43095533
164Toxoplasmosis_Homo sapiens_hsa051450.42823701
165Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40331352
166Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40027554
167Sulfur metabolism_Homo sapiens_hsa009200.39955998
168Synaptic vesicle cycle_Homo sapiens_hsa047210.38726833
169PPAR signaling pathway_Homo sapiens_hsa033200.37617031
170Neurotrophin signaling pathway_Homo sapiens_hsa047220.35545976
171Epstein-Barr virus infection_Homo sapiens_hsa051690.33878235
172Glutathione metabolism_Homo sapiens_hsa004800.33828406
173Leukocyte transendothelial migration_Homo sapiens_hsa046700.33328477
174Prolactin signaling pathway_Homo sapiens_hsa049170.29995528
175SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22386615
176Endocytosis_Homo sapiens_hsa041440.19145536
177Ether lipid metabolism_Homo sapiens_hsa005650.10795888

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