COL24A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the collagen gene family and is thought to regulate type I collagen fibrillogenesis during fetal development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of norepinephrine secretion (GO:0010700)7.32415491
2locomotory exploration behavior (GO:0035641)7.23697236
3phenylpropanoid metabolic process (GO:0009698)7.05623671
4definitive hemopoiesis (GO:0060216)6.18932256
5thrombin receptor signaling pathway (GO:0070493)5.89243417
6parturition (GO:0007567)5.69996200
7interkinetic nuclear migration (GO:0022027)5.14764997
8positive regulation of vasculogenesis (GO:2001214)5.12728264
9negative regulation of catecholamine secretion (GO:0033604)5.03373715
10bone trabecula formation (GO:0060346)5.01224707
11angiogenesis involved in wound healing (GO:0060055)4.91414372
12positive regulation of granulocyte differentiation (GO:0030854)4.73544936
13protein K11-linked deubiquitination (GO:0035871)4.59758958
14positive regulation of B cell differentiation (GO:0045579)4.59619718
15collagen fibril organization (GO:0030199)4.46869684
16exploration behavior (GO:0035640)4.44352029
17regulation of female gonad development (GO:2000194)4.42399928
18positive regulation of digestive system process (GO:0060456)4.35232977
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33397395
20glucocorticoid biosynthetic process (GO:0006704)4.31238028
21protein heterotrimerization (GO:0070208)4.30585785
22mesenchymal-epithelial cell signaling (GO:0060638)4.28183481
23neutrophil activation involved in immune response (GO:0002283)4.27722947
24negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.21106320
25regulation of gonadotropin secretion (GO:0032276)4.12397728
26negative regulation of erythrocyte differentiation (GO:0045647)4.11319910
27prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.11249984
28planar cell polarity pathway involved in neural tube closure (GO:0090179)4.07429935
29growth hormone receptor signaling pathway (GO:0060396)4.07313528
30regulation of B cell receptor signaling pathway (GO:0050855)4.07148298
31lateral sprouting from an epithelium (GO:0060601)4.03804783
32B cell receptor signaling pathway (GO:0050853)3.96705965
33regulation of germinal center formation (GO:0002634)3.95727862
34hematopoietic stem cell proliferation (GO:0071425)3.94785310
35regulation of B cell apoptotic process (GO:0002902)3.88788529
36negative regulation of B cell apoptotic process (GO:0002903)3.86895692
37poly(A)+ mRNA export from nucleus (GO:0016973)3.86721025
38regulation of glucocorticoid secretion (GO:2000849)3.84905805
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.83173255
40regulation of norepinephrine secretion (GO:0014061)3.76630168
41cellular response to vitamin D (GO:0071305)3.75151480
42megakaryocyte development (GO:0035855)3.73230051
43tyrosine phosphorylation of STAT protein (GO:0007260)3.67975628
44peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.67851364
45germinal center formation (GO:0002467)3.67705216
46vocalization behavior (GO:0071625)3.58995550
47cellular response to growth hormone stimulus (GO:0071378)3.56629214
48sequestering of extracellular ligand from receptor (GO:0035581)3.55890217
49regulation of integrin activation (GO:0033623)3.54741954
50regulation of vasculogenesis (GO:2001212)3.54694204
51chondrocyte proliferation (GO:0035988)3.53753615
52parental behavior (GO:0060746)3.53193575
53chondrocyte development (GO:0002063)3.51591647
54negative regulation of granulocyte differentiation (GO:0030853)3.51475435
55negative regulation of interleukin-8 production (GO:0032717)3.49348800
56epithelial cell differentiation involved in kidney development (GO:0035850)3.47619145
57craniofacial suture morphogenesis (GO:0097094)3.45184628
58insulin-like growth factor receptor signaling pathway (GO:0048009)3.42507299
59positive regulation of gamma-delta T cell activation (GO:0046645)3.42157669
60regulation of platelet aggregation (GO:0090330)3.39641912
61histamine secretion (GO:0001821)3.36215974
62regulation of penile erection (GO:0060405)3.34821576
63positive regulation of steroid hormone secretion (GO:2000833)3.32752452
64immunoglobulin mediated immune response (GO:0016064)3.32460912
65regulation of glutamate receptor signaling pathway (GO:1900449)3.32012639
66regulation of granulocyte differentiation (GO:0030852)3.29904288
67regulation of corticosteroid hormone secretion (GO:2000846)3.29898061
68collagen catabolic process (GO:0030574)3.28839648
69phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.26453809
70regulation of B cell differentiation (GO:0045577)3.24700116
71regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.24202962
72cellular response to ammonium ion (GO:0071242)3.23510134
73collagen metabolic process (GO:0032963)3.22789591
74synaptic transmission, dopaminergic (GO:0001963)3.22579663
75glycoprotein catabolic process (GO:0006516)3.19286367
76purinergic nucleotide receptor signaling pathway (GO:0035590)3.18728756
77negative regulation of T-helper cell differentiation (GO:0045623)3.18582897
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18582897
79regulation of inositol phosphate biosynthetic process (GO:0010919)3.17882535
80negative regulation of thymocyte apoptotic process (GO:0070244)3.16332749
81Peyers patch development (GO:0048541)3.16232919
82mucosal-associated lymphoid tissue development (GO:0048537)3.16232919
83endothelium development (GO:0003158)3.15802717
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.15469999
85midgut development (GO:0007494)3.15336818
86cellular response to vitamin (GO:0071295)3.13392556
87purine nucleotide salvage (GO:0032261)3.13145636
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10890470
89regulation of memory T cell differentiation (GO:0043380)3.09830298
90regulation of mast cell activation involved in immune response (GO:0033006)3.09475013
91convergent extension (GO:0060026)3.07575823
92Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.07402956
93negative regulation of circadian rhythm (GO:0042754)3.06770784
94regulation of hypersensitivity (GO:0002883)3.06344234
95histone H3-K9 methylation (GO:0051567)3.06009205
96multicellular organismal macromolecule metabolic process (GO:0044259)3.05658028
97regulation of mast cell activation (GO:0033003)3.01333125
98regulation of short-term neuronal synaptic plasticity (GO:0048172)3.00947278
99cellular response to dexamethasone stimulus (GO:0071549)3.00429998
100hypothalamus development (GO:0021854)3.00246321
101branching involved in prostate gland morphogenesis (GO:0060442)2.98619549
102nerve growth factor signaling pathway (GO:0038180)2.98563390
103mature B cell differentiation involved in immune response (GO:0002313)2.97595502
104regulation of axon extension involved in axon guidance (GO:0048841)2.97317645
105multicellular organismal catabolic process (GO:0044243)2.97006122
106regulation of establishment of planar polarity (GO:0090175)2.96987019
107regulation of platelet activation (GO:0010543)2.95525239
108phagocytosis, recognition (GO:0006910)2.95179197
109dermatan sulfate biosynthetic process (GO:0030208)2.95088124
110G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.95020619
111negative regulation of catenin import into nucleus (GO:0035414)2.94849557
112establishment of tissue polarity (GO:0007164)2.94012873
113establishment of planar polarity (GO:0001736)2.94012873
114positive regulation of Rap GTPase activity (GO:0032854)2.92171484
115regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91041959
116multicellular organismal metabolic process (GO:0044236)2.88449143
117maternal behavior (GO:0042711)2.87911736
118regulation of T-helper 1 cell differentiation (GO:0045625)2.87578058
119cellular response to exogenous dsRNA (GO:0071360)2.86392151
120positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.86023867
121dosage compensation (GO:0007549)2.85433420
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84401614
123regulation of pigment cell differentiation (GO:0050932)2.84046174
124negative regulation of amine transport (GO:0051953)2.83591888
125endochondral ossification (GO:0001958)2.83247451
126replacement ossification (GO:0036075)2.83247451
127glucocorticoid metabolic process (GO:0008211)2.82069706
128regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80730200
129axonal fasciculation (GO:0007413)2.80319390
130ether lipid metabolic process (GO:0046485)2.80264328
131response to hydroperoxide (GO:0033194)2.79829744
132response to dexamethasone (GO:0071548)2.78286925
133response to gravity (GO:0009629)2.78172986
134lung lobe morphogenesis (GO:0060463)2.77153906
135histone H3-K9 modification (GO:0061647)2.76780169
136seminiferous tubule development (GO:0072520)2.76726386
137negative regulation of chondrocyte differentiation (GO:0032331)2.75748109
138positive regulation of glycogen biosynthetic process (GO:0045725)2.75491345
139cell wall macromolecule metabolic process (GO:0044036)2.75244977
140adrenal gland development (GO:0030325)2.75176788
141regulation of mast cell degranulation (GO:0043304)2.75146757
142axon extension involved in axon guidance (GO:0048846)2.73441825
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.73441825
144tooth mineralization (GO:0034505)2.72846490
145cell wall macromolecule catabolic process (GO:0016998)2.72603532
146negative regulation of axon extension involved in axon guidance (GO:0048843)2.72537344
147B cell mediated immunity (GO:0019724)2.71491650
148embryonic hemopoiesis (GO:0035162)2.70852057
149mucosal immune response (GO:0002385)2.70163956
150regulation of axon guidance (GO:1902667)2.69723898
151positive regulation of mesenchymal cell proliferation (GO:0002053)2.68257509
152negative regulation of exocytosis (GO:0045920)2.67719424
153positive regulation of mast cell activation (GO:0033005)2.66541112
154long-term memory (GO:0007616)2.66113776
155positive regulation of calcium ion import (GO:0090280)2.65552899
156negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.63881726
157dermatan sulfate metabolic process (GO:0030205)2.63685003
158negative regulation of calcium ion transport into cytosol (GO:0010523)2.62425702
159negative regulation of embryonic development (GO:0045992)2.62380655
160regulation of erythrocyte differentiation (GO:0045646)2.62069961
161regulation of histone H3-K9 methylation (GO:0051570)2.61304186
162histamine transport (GO:0051608)2.61031770
163neutrophil activation (GO:0042119)2.59148141
164cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.58698116
165negative regulation of neurotransmitter transport (GO:0051589)2.58460928
166negative chemotaxis (GO:0050919)2.58348262
167keratan sulfate catabolic process (GO:0042340)2.57976283
168biomineral tissue development (GO:0031214)2.57951680
169non-canonical Wnt signaling pathway (GO:0035567)2.57938541
170metanephric mesenchyme development (GO:0072075)2.57933674
171embryonic cranial skeleton morphogenesis (GO:0048701)2.57682812
172camera-type eye morphogenesis (GO:0048593)2.57074819
173positive regulation of glycogen metabolic process (GO:0070875)2.56597397
174regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.56024539
175histone H3-K4 trimethylation (GO:0080182)2.55437200
176endodermal cell differentiation (GO:0035987)2.54808404
177positive regulation of alpha-beta T cell differentiation (GO:0046638)2.54784325
178regulation of mesenchymal cell proliferation (GO:0010464)2.53285206
179gonadal mesoderm development (GO:0007506)2.52497992
180lipid translocation (GO:0034204)2.52040898
181phospholipid translocation (GO:0045332)2.52040898
182outer ear morphogenesis (GO:0042473)2.51800694
183positive regulation of cAMP-mediated signaling (GO:0043950)2.51473083
184regulation of Rap GTPase activity (GO:0032317)2.50826702
185organ or tissue specific immune response (GO:0002251)2.50447783
186extracellular regulation of signal transduction (GO:1900115)2.50183393
187extracellular negative regulation of signal transduction (GO:1900116)2.50183393
188extracellular matrix disassembly (GO:0022617)2.49777426
189regulation of leukocyte degranulation (GO:0043300)2.49382767
190exocrine pancreas development (GO:0031017)2.48918192
191serotonin receptor signaling pathway (GO:0007210)2.48236873
192protein K63-linked deubiquitination (GO:0070536)2.47645066
193protein localization to synapse (GO:0035418)2.47201933
194regulation of catenin import into nucleus (GO:0035412)2.46936877
195JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.46111036
196myeloid cell development (GO:0061515)2.44814534
197activated T cell proliferation (GO:0050798)2.44684489
198leukocyte degranulation (GO:0043299)2.44359293

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.04452087
2SCL_19346495_ChIP-Seq_HPC-7_Human4.28886655
3EZH2_22144423_ChIP-Seq_EOC_Human3.84472344
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.01137049
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95919167
6GBX2_23144817_ChIP-Seq_PC3_Human2.88269426
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.79398772
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.77992976
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77954511
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.73833605
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68816685
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68816685
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67512983
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58981394
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56579277
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55269764
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.50091266
18* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.48462900
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47847170
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42631267
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.42235073
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41822448
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.40275743
24* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.17940336
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.08419896
26VDR_24763502_ChIP-Seq_THP-1_Human2.04923985
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02716382
28EWS_26573619_Chip-Seq_HEK293_Human2.02216178
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.02142156
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01818044
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.01774300
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00990282
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.00273026
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99577345
35VDR_24787735_ChIP-Seq_THP-1_Human1.97661917
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.92454048
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92248385
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92086896
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90714816
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89462426
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.86034795
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83179593
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82504782
44RUNX_20019798_ChIP-Seq_JUKART_Human1.82321552
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81656972
46SPI1_23127762_ChIP-Seq_K562_Human1.76511160
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.72600010
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70385496
49MYB_26560356_Chip-Seq_TH2_Human1.70373077
50AR_21572438_ChIP-Seq_LNCaP_Human1.69815158
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.69638287
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68227676
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67464259
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67378100
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66952783
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.66122878
57IGF1R_20145208_ChIP-Seq_DFB_Human1.66094412
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63832269
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62785335
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62671139
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62162507
62* SMAD4_21799915_ChIP-Seq_A2780_Human1.61987171
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.61736736
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59011456
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.58216972
66DROSHA_22980978_ChIP-Seq_HELA_Human1.57157923
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53442379
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.52691974
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.51358929
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50881624
71P300_19829295_ChIP-Seq_ESCs_Human1.49737361
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46428555
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46135552
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45515778
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45478080
76* FUS_26573619_Chip-Seq_HEK293_Human1.45221955
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44969781
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.44550117
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.42900999
80TAF15_26573619_Chip-Seq_HEK293_Human1.42722679
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42701778
82TP53_18474530_ChIP-ChIP_U2OS_Human1.42662640
83GATA3_27048872_Chip-Seq_THYMUS_Human1.41433831
84ER_23166858_ChIP-Seq_MCF-7_Human1.40678673
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.38430484
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.37915497
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.37597476
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37284111
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35963700
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.34223175
91VDR_21846776_ChIP-Seq_THP-1_Human1.32035535
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31521155
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30206045
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.28611392
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.28397976
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27709907
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.27313480
98GATA1_22025678_ChIP-Seq_K562_Human1.25818412
99SPI1_23547873_ChIP-Seq_NB4_Human1.25635845
100MYB_26560356_Chip-Seq_TH1_Human1.24878991
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24497008
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.23411465
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23297329
104* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23133042
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22672641
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22672641
107GATA1_19941826_ChIP-Seq_K562_Human1.22456557
108CJUN_26792858_Chip-Seq_BT549_Human1.22430212
109RING1B_27294783_Chip-Seq_NPCs_Mouse1.20568280
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19199338
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.19016336
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18695909
113GATA3_26560356_Chip-Seq_TH2_Human1.17829608
114CBP_20019798_ChIP-Seq_JUKART_Human1.17460319
115IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17460319
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17365236
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16642718
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.16437742
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16056410
120GATA1_19941827_ChIP-Seq_MEL_Mouse1.14903702
121ISL1_27105846_Chip-Seq_CPCs_Mouse1.14667591
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14539922
123CIITA_25753668_ChIP-Seq_RAJI_Human1.13890275
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12134236
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11287424
126AR_25329375_ChIP-Seq_VCAP_Human1.09560649
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08861482
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08729754
129AHR_22903824_ChIP-Seq_MCF-7_Human1.08067197
130ETS1_22383799_ChIP-Seq_G1ME_Mouse1.07967827
131GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07933429
132IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07467938
133AR_19668381_ChIP-Seq_PC3_Human1.06802310
134KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05499360
135STAT3_23295773_ChIP-Seq_U87_Human1.05092615
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04895770
137P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04556596
138BCAT_22108803_ChIP-Seq_LS180_Human1.04484041
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04442589
140YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03963567
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03591796
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03210856
143RXR_22108803_ChIP-Seq_LS180_Human1.02591032
144* TCF4_23295773_ChIP-Seq_U87_Human1.01807907
145ESR1_20079471_ChIP-ChIP_T-47D_Human1.01330410
146TP53_22573176_ChIP-Seq_HFKS_Human1.01084568
147ZNF274_21170338_ChIP-Seq_K562_Hela1.01070785
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00068632
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99653533
150GATA2_19941826_ChIP-Seq_K562_Human0.98932763
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98091833
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97988596
153TP53_16413492_ChIP-PET_HCT116_Human0.97394047
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.97044864
155TCF4_18268006_ChIP-ChIP_LS174T_Human0.95911715
156VDR_22108803_ChIP-Seq_LS180_Human0.95860411
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.95524659
158FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93912638
159RUNX2_22187159_ChIP-Seq_PCA_Human0.93629478
160RNF2_27304074_Chip-Seq_NSC_Mouse0.92941026
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91828348
162* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91748145
163* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91748145
164* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91460344
165REST_21632747_ChIP-Seq_MESCs_Mouse0.90785755
166* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90713761
167OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90264334
168TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89643214
169TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89213620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.65411469
2MP0005503_abnormal_tendon_morphology5.62676935
3MP0005464_abnormal_platelet_physiology4.48715514
4MP0005275_abnormal_skin_tensile3.99466641
5MP0003183_abnormal_peptide_metabolism3.88391724
6MP0002396_abnormal_hematopoietic_system3.55344246
7MP0001835_abnormal_antigen_presentation3.30789966
8MP0010368_abnormal_lymphatic_system3.08044581
9MP0004808_abnormal_hematopoietic_stem2.90277681
10MP0001542_abnormal_bone_strength2.84030855
11MP0002138_abnormal_hepatobiliary_system2.80211216
12MP0009250_abnormal_appendicular_skeleto2.64254493
13MP0005397_hematopoietic_system_phenotyp2.56512453
14MP0001545_abnormal_hematopoietic_system2.56512453
15MP0009053_abnormal_anal_canal2.48996964
16MP0003122_maternal_imprinting2.45557004
17MP0003385_abnormal_body_wall2.41120855
18MP0002108_abnormal_muscle_morphology2.37692514
19MP0004859_abnormal_synaptic_plasticity2.36737090
20MP0004272_abnormal_basement_membrane2.35380623
21MP0002166_altered_tumor_susceptibility2.34476890
22MP0000015_abnormal_ear_pigmentation2.33971891
23MP0000465_gastrointestinal_hemorrhage2.32205511
24MP0005167_abnormal_blood-brain_barrier2.30950796
25MP0002896_abnormal_bone_mineralization2.27818368
26MP0009278_abnormal_bone_marrow2.26060092
27MP0004134_abnormal_chest_morphology2.18965194
28MP0005409_darkened_coat_color2.18557671
29MP0002006_tumorigenesis2.15945707
30MP0008057_abnormal_DNA_replication2.14573544
31MP0005174_abnormal_tail_pigmentation2.12486341
32MP0002009_preneoplasia2.12303201
33MP0009697_abnormal_copulation2.08250448
34MP0001299_abnormal_eye_distance/2.07390035
35MP0010030_abnormal_orbit_morphology1.96281120
36MP0005508_abnormal_skeleton_morphology1.96079922
37MP0001879_abnormal_lymphatic_vessel1.92376846
38MP0003115_abnormal_respiratory_system1.90725668
39MP0005257_abnormal_intraocular_pressure1.88087427
40MP0009384_cardiac_valve_regurgitation1.87103599
41MP0003705_abnormal_hypodermis_morpholog1.85632683
42MP0000566_synostosis1.84017599
43MP0000751_myopathy1.82777632
44MP0002282_abnormal_trachea_morphology1.82387491
45MP0003724_increased_susceptibility_to1.79151241
46MP0002115_abnormal_skeleton_extremities1.76986140
47MP0005646_abnormal_pituitary_gland1.76452695
48MP0004185_abnormal_adipocyte_glucose1.74823683
49MP0003283_abnormal_digestive_organ1.72829276
50MP0002398_abnormal_bone_marrow1.72774082
51MP0001851_eye_inflammation1.70900588
52MP0009379_abnormal_foot_pigmentation1.70862372
53MP0000534_abnormal_ureter_morphology1.70656107
54MP0005623_abnormal_meninges_morphology1.70598971
55MP0002148_abnormal_hypersensitivity_rea1.70350424
56MP0004084_abnormal_cardiac_muscle1.69854389
57MP0003279_aneurysm1.67859220
58MP0003942_abnormal_urinary_system1.64532222
59MP0001958_emphysema1.64378321
60MP0001800_abnormal_humoral_immune1.60380053
61MP0002249_abnormal_larynx_morphology1.60290864
62MP0003880_abnormal_central_pattern1.53870464
63MP0003937_abnormal_limbs/digits/tail_de1.53165002
64MP0003123_paternal_imprinting1.52971036
65MP0000762_abnormal_tongue_morphology1.52899531
66MP0003755_abnormal_palate_morphology1.52230842
67MP0000428_abnormal_craniofacial_morphol1.51908274
68MP0002109_abnormal_limb_morphology1.51795099
69MP0000163_abnormal_cartilage_morphology1.51708240
70MP0003172_abnormal_lysosome_physiology1.48939430
71MP0002420_abnormal_adaptive_immunity1.46579074
72MP0000685_abnormal_immune_system1.46498121
73MP0000537_abnormal_urethra_morphology1.46439618
74MP0005084_abnormal_gallbladder_morpholo1.44895367
75MP0002452_abnormal_antigen_presenting1.44892012
76MP0002419_abnormal_innate_immunity1.43779062
77MP0001819_abnormal_immune_cell1.43484451
78MP0009780_abnormal_chondrocyte_physiolo1.43462735
79MP0002723_abnormal_immune_serum1.40545136
80MP0002233_abnormal_nose_morphology1.39383620
81MP0002932_abnormal_joint_morphology1.38919005
82MP0000716_abnormal_immune_system1.37650857
83MP0005000_abnormal_immune_tolerance1.37210473
84MP0000689_abnormal_spleen_morphology1.36318992
85MP0002998_abnormal_bone_remodeling1.36053292
86MP0009764_decreased_sensitivity_to1.36008471
87MP0002116_abnormal_craniofacial_bone1.34275762
88MP0005645_abnormal_hypothalamus_physiol1.32369167
89MP0004145_abnormal_muscle_electrophysio1.31850123
90MP0002295_abnormal_pulmonary_circulatio1.31804862
91MP0003763_abnormal_thymus_physiology1.30358597
92MP0002113_abnormal_skeleton_development1.30136563
93MP0003935_abnormal_craniofacial_develop1.28930372
94MP0008875_abnormal_xenobiotic_pharmacok1.28851531
95MP0000230_abnormal_systemic_arterial1.28204391
96MP0001270_distended_abdomen1.26619723
97MP0006292_abnormal_olfactory_placode1.25530148
98MP0001968_abnormal_touch/_nociception1.22980676
99MP0005075_abnormal_melanosome_morpholog1.21300945
100MP0003436_decreased_susceptibility_to1.20439214
101MP0002429_abnormal_blood_cell1.19133623
102MP0000049_abnormal_middle_ear1.18961584
103MP0004782_abnormal_surfactant_physiolog1.18357971
104MP0002722_abnormal_immune_system1.17985349
105MP0004043_abnormal_pH_regulation1.17683519
106MP0005187_abnormal_penis_morphology1.16768559
107MP0004858_abnormal_nervous_system1.15869555
108MP0001986_abnormal_taste_sensitivity1.14711372
109MP0002938_white_spotting1.13853783
110MP0003938_abnormal_ear_development1.13503288
111MP0008961_abnormal_basal_metabolism1.12990456
112MP0003635_abnormal_synaptic_transmissio1.12876311
113MP0005670_abnormal_white_adipose1.12752471
114MP0000432_abnormal_head_morphology1.12382848
115MP0008872_abnormal_physiological_respon1.10900104
116MP0003121_genomic_imprinting1.10013922
117MP0003828_pulmonary_edema1.08867610
118MP0004233_abnormal_muscle_weight1.08387197
119MP0005387_immune_system_phenotype1.08245286
120MP0001790_abnormal_immune_system1.08245286
121MP0000703_abnormal_thymus_morphology1.07219726
122MP0001853_heart_inflammation1.07033439
123MP0004036_abnormal_muscle_relaxation1.06617411
124MP0006054_spinal_hemorrhage1.06320712
125MP0002095_abnormal_skin_pigmentation1.05911532
126MP0000013_abnormal_adipose_tissue1.05854731
127MP0005025_abnormal_response_to1.05167043
128MP0006276_abnormal_autonomic_nervous1.04826610
129MP0000372_irregular_coat_pigmentation1.04522174
130MP0005220_abnormal_exocrine_pancreas1.02731301
131MP0000249_abnormal_blood_vessel1.02430871
132MP0004484_altered_response_of1.01497545
133MP0002837_dystrophic_cardiac_calcinosis1.01234085
134MP0001849_ear_inflammation1.00189445
135MP0003718_maternal_effect0.99935626
136MP0005390_skeleton_phenotype0.99494415
137MP0001177_atelectasis0.99052095
138MP0002405_respiratory_system_inflammati0.97844167
139MP0010155_abnormal_intestine_physiology0.97755476
140MP0004130_abnormal_muscle_cell0.95488406
141MP0005369_muscle_phenotype0.95033607
142MP0005310_abnormal_salivary_gland0.94693126
143MP0005171_absent_coat_pigmentation0.94312868
144MP0008775_abnormal_heart_ventricle0.92863877
145MP0000462_abnormal_digestive_system0.92528804
146MP0002114_abnormal_axial_skeleton0.92365913
147MP0000733_abnormal_muscle_development0.92195936
148MP0002060_abnormal_skin_morphology0.90793988
149MP0008004_abnormal_stomach_pH0.90716960
150MP0000383_abnormal_hair_follicle0.90650537
151MP0002184_abnormal_innervation0.90477164
152MP0003943_abnormal_hepatobiliary_system0.86491899
153MP0001188_hyperpigmentation0.83769427
154MP0005388_respiratory_system_phenotype0.83753376
155MP0002133_abnormal_respiratory_system0.83753376
156MP0003303_peritoneal_inflammation0.83298492
157MP0002735_abnormal_chemical_nociception0.80845851
158MP0009046_muscle_twitch0.79770711
159MP0003045_fibrosis0.79253718
160MP0003646_muscle_fatigue0.77904828
161MP0002064_seizures0.77348049
162MP0001501_abnormal_sleep_pattern0.76986817
163MP0002063_abnormal_learning/memory/cond0.76735098
164MP0002928_abnormal_bile_duct0.76141145
165MP0000759_abnormal_skeletal_muscle0.76086414
166MP0005535_abnormal_body_temperature0.74824230
167MP0006082_CNS_inflammation0.74491154
168MP0003795_abnormal_bone_structure0.73991054
169MP0002736_abnormal_nociception_after0.73653358
170MP0008877_abnormal_DNA_methylation0.73149656
171MP0002177_abnormal_outer_ear0.72154867
172MP0004147_increased_porphyrin_level0.71827761
173MP0000639_abnormal_adrenal_gland0.71805845
174MP0000569_abnormal_digit_pigmentation0.70958129
175MP0009745_abnormal_behavioral_response0.70659299
176MP0002089_abnormal_postnatal_growth/wei0.70457238
177MP0005248_abnormal_Harderian_gland0.68711899
178MP0001784_abnormal_fluid_regulation0.68437584
179MP0000955_abnormal_spinal_cord0.68198413
180MP0001845_abnormal_inflammatory_respons0.68041958
181MP0001486_abnormal_startle_reflex0.67947939
182MP0002734_abnormal_mechanical_nocicepti0.67920640
183MP0001243_abnormal_dermal_layer0.67889880
184MP0009703_decreased_birth_body0.67837162
185MP0005395_other_phenotype0.67558032
186MP0000778_abnormal_nervous_system0.67322857
187MP0000516_abnormal_urinary_system0.67219142
188MP0005367_renal/urinary_system_phenotyp0.67219142
189MP0001533_abnormal_skeleton_physiology0.66836104
190MP0002128_abnormal_blood_circulation0.66148828
191MP0000579_abnormal_nail_morphology0.62914352
192MP0002111_abnormal_tail_morphology0.61891226

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.33369825
2Prolonged bleeding time (HP:0003010)6.15071471
3Acute lymphatic leukemia (HP:0006721)5.26238977
4Panhypogammaglobulinemia (HP:0003139)4.94338651
5Elevated erythrocyte sedimentation rate (HP:0003565)4.72253151
6Abnormality of B cell number (HP:0010975)4.69868683
7Agammaglobulinemia (HP:0004432)4.59236894
8Premature rupture of membranes (HP:0001788)4.54080584
9Epistaxis (HP:0000421)4.32481634
10Petechiae (HP:0000967)4.20147027
11Broad metatarsal (HP:0001783)4.12756298
12Shallow orbits (HP:0000586)3.99994172
13B lymphocytopenia (HP:0010976)3.93261638
14Autoimmune thrombocytopenia (HP:0001973)3.92908815
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.89676742
16Gingival bleeding (HP:0000225)3.89209178
17Acute myeloid leukemia (HP:0004808)3.81814875
18Neonatal short-limb short stature (HP:0008921)3.73761112
19Mesomelia (HP:0003027)3.64060996
20Increased mean platelet volume (HP:0011877)3.56915394
21Abnormal platelet volume (HP:0011876)3.51860235
22Type 1 muscle fiber predominance (HP:0003803)3.45437473
23Abnormality of the fingertips (HP:0001211)3.39131844
24Abnormality of the prostate (HP:0008775)3.37204596
25Atrophic scars (HP:0001075)3.36012083
26Thrombocytosis (HP:0001894)3.34821341
27Dyschromatopsia (HP:0007641)3.31916288
28Aortic dissection (HP:0002647)3.25321598
29Papilledema (HP:0001085)3.23800596
30Chronic mucocutaneous candidiasis (HP:0002728)3.16541966
31Recurrent cutaneous fungal infections (HP:0011370)3.16541966
32Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.15243410
33Short 4th metacarpal (HP:0010044)3.15243410
34Bell-shaped thorax (HP:0001591)3.13944175
35Autoimmune hemolytic anemia (HP:0001890)3.10894540
36Abnormal platelet function (HP:0011869)3.10309778
37Impaired platelet aggregation (HP:0003540)3.10309778
38Soft skin (HP:0000977)3.08157111
39Hypoplastic ischia (HP:0003175)3.07551254
40Menorrhagia (HP:0000132)3.07175048
41Abnormality of dentin (HP:0010299)3.06762131
42Granulocytopenia (HP:0001913)3.04680772
43Ankle contracture (HP:0006466)3.00441062
44Chronic otitis media (HP:0000389)2.97297811
45Slender build (HP:0001533)2.96553275
46Eosinophilia (HP:0001880)2.95300338
47Fatigue (HP:0012378)2.93986371
48Bladder diverticulum (HP:0000015)2.90460814
49Purpura (HP:0000979)2.90331993
50Chest pain (HP:0100749)2.87622270
51Recurrent fungal infections (HP:0002841)2.87439271
52Follicular hyperkeratosis (HP:0007502)2.86535456
53Meningitis (HP:0001287)2.84897888
54Stomach cancer (HP:0012126)2.82993427
55Mild short stature (HP:0003502)2.82579041
56Peritonitis (HP:0002586)2.81851657
57Narrow nasal bridge (HP:0000446)2.78390994
58Abnormality of the ischium (HP:0003174)2.71628831
59Wide anterior fontanel (HP:0000260)2.68896774
60Biconcave vertebral bodies (HP:0004586)2.64552629
61Wormian bones (HP:0002645)2.63941150
62Arterial thrombosis (HP:0004420)2.58048155
63Coronal craniosynostosis (HP:0004440)2.56181064
64Encephalitis (HP:0002383)2.55442017
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.55169422
66Blue sclerae (HP:0000592)2.54819655
67Osteoarthritis (HP:0002758)2.54602996
68Focal motor seizures (HP:0011153)2.52582109
69Mitral valve prolapse (HP:0001634)2.49571969
70Decreased central vision (HP:0007663)2.49265083
71Morphological abnormality of the middle ear (HP:0008609)2.49022189
72Genu recurvatum (HP:0002816)2.48952624
73Abnormality of the 4th metacarpal (HP:0010012)2.48722356
74Atonic seizures (HP:0010819)2.45579216
75Viral hepatitis (HP:0006562)2.44663155
76Recurrent viral infections (HP:0004429)2.44445895
77Short middle phalanx of the 5th finger (HP:0004220)2.44165212
78Fragile skin (HP:0001030)2.43528877
79Abolished electroretinogram (ERG) (HP:0000550)2.43406783
80Abnormality of the middle phalanges of the toes (HP:0010183)2.42673918
81Spontaneous hematomas (HP:0007420)2.37633569
82Broad long bones (HP:0005622)2.37551736
83Attenuation of retinal blood vessels (HP:0007843)2.37305052
84Turricephaly (HP:0000262)2.37066483
85Leukocytosis (HP:0001974)2.36299400
86Microglossia (HP:0000171)2.35799495
87Ulnar bowing (HP:0003031)2.34763331
88Deviation of the hallux (HP:0010051)2.34308204
89Overgrowth (HP:0001548)2.31907941
90Small epiphyses (HP:0010585)2.30892269
91Rhizomelia (HP:0008905)2.29712377
92Abnormality of T cell physiology (HP:0011840)2.29498259
93Thyroiditis (HP:0100646)2.29147935
94Abnormality of the peritoneum (HP:0002585)2.27995115
95Renal duplication (HP:0000075)2.22973193
96Hyperextensible skin (HP:0000974)2.22409357
97Mildly elevated creatine phosphokinase (HP:0008180)2.21418942
98Prostate neoplasm (HP:0100787)2.20616457
99Congenital stationary night blindness (HP:0007642)2.19227152
100Spontaneous abortion (HP:0005268)2.18900693
101Femoral bowing (HP:0002980)2.18702485
102Broad toe (HP:0001837)2.18260282
103Increased variability in muscle fiber diameter (HP:0003557)2.17039073
104Dilatation of the ascending aorta (HP:0005111)2.15168576
105Tinnitus (HP:0000360)2.13883840
106Synostosis involving the elbow (HP:0003938)2.12603120
107Humeroradial synostosis (HP:0003041)2.12603120
108Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09370881
109Increased neuronal autofluorescent lipopigment (HP:0002074)2.09051250
110Hallux valgus (HP:0001822)2.08261689
111Metaphyseal cupping (HP:0003021)2.07791931
112Growth hormone deficiency (HP:0000824)2.07525921
113Abnormality of eosinophils (HP:0001879)2.07318869
114Bruising susceptibility (HP:0000978)2.06165133
115Aortic aneurysm (HP:0004942)2.05883822
116Infantile muscular hypotonia (HP:0008947)2.05165455
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04593457
118Febrile seizures (HP:0002373)2.04408040
119Abnormality of the 2nd finger (HP:0004100)2.03653953
120Flared iliac wings (HP:0002869)2.03008378
121Broad thumb (HP:0011304)2.02845784
122Cervical subluxation (HP:0003308)2.02543899
123Short hallux (HP:0010109)2.02337610
124Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02238627
125Polydipsia (HP:0001959)2.00902327
126Abnormal drinking behavior (HP:0030082)2.00902327
127Decreased circulating renin level (HP:0003351)2.00740521
128Colitis (HP:0002583)2.00490775
129Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97774166
130Fair hair (HP:0002286)1.97611619
131Mesangial abnormality (HP:0001966)1.97465194
132Poikilocytosis (HP:0004447)1.96795937
133Broad phalanx (HP:0006009)1.96411679
134Amaurosis fugax (HP:0100576)1.96280309
135Abnormality of male internal genitalia (HP:0000022)1.96051570
136Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95098331
137Bowel diverticulosis (HP:0005222)1.94509485
138Spinal rigidity (HP:0003306)1.94209106
139Focal seizures (HP:0007359)1.93968397
140Pulmonary embolism (HP:0002204)1.93778513
141Deformed tarsal bones (HP:0008119)1.93318942
142Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93141430
143Vertebral compression fractures (HP:0002953)1.92852504
144Limited hip movement (HP:0008800)1.92773817
145Epiphyseal dysplasia (HP:0002656)1.92145503
146Clumsiness (HP:0002312)1.92098221
147Broad ribs (HP:0000885)1.91721880
148Abnormality of the heme biosynthetic pathway (HP:0010472)1.91677766
149Inflammation of the large intestine (HP:0002037)1.90834158
150Increased IgE level (HP:0003212)1.90723392
151Neoplasm of the tracheobronchial system (HP:0100552)1.90721119
152Breech presentation (HP:0001623)1.90231956
153Broad finger (HP:0001500)1.90158630
154Papillary thyroid carcinoma (HP:0002895)1.89813505
155Abnormality of the humeroradial joint (HP:0100744)1.89397489
156Hip contracture (HP:0003273)1.88336992
157Dysostosis multiplex (HP:0000943)1.88294020
158Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.87928907
159Myositis (HP:0100614)1.87824008
160Abnormality of the parietal bone (HP:0002696)1.87519664
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87509149
162Abnormality of the phalanges of the 5th finger (HP:0004213)1.87394458
163Wrist flexion contracture (HP:0001239)1.87275622
164Vasculitis (HP:0002633)1.87150381
165Tibial bowing (HP:0002982)1.87129222
166Joint laxity (HP:0001388)1.86536152
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.86429717
168Absent/shortened dynein arms (HP:0200106)1.86429717
169Thrombophlebitis (HP:0004418)1.86367007
170Short metatarsal (HP:0010743)1.86283742
171Narrow palate (HP:0000189)1.85563396
172Cupped ribs (HP:0000887)1.85007239
173Radial bowing (HP:0002986)1.84975283
174Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84316653
175Central scotoma (HP:0000603)1.84284115
176Abnormality of skeletal muscle fiber size (HP:0012084)1.83798120
177Short middle phalanx of finger (HP:0005819)1.81992795
178Vascular tortuosity (HP:0004948)1.81692122
179Osteopenia (HP:0000938)1.81540957
180Cerebral aneurysm (HP:0004944)1.81107151
181Gastrointestinal inflammation (HP:0004386)1.80953241
182Myelodysplasia (HP:0002863)1.80678948
183Vertigo (HP:0002321)1.78935593
184Conjunctival telangiectasia (HP:0000524)1.77555744
185Generalized hypopigmentation of hair (HP:0011358)1.76977940
186Hypokalemic alkalosis (HP:0001949)1.76653464
187Alveolar cell carcinoma (HP:0006519)1.75730999
188Abnormality of lateral ventricle (HP:0030047)1.75235972
189Recurrent abscess formation (HP:0002722)1.71605500
190Metaphyseal dysplasia (HP:0100255)1.70755482
191Amyotrophic lateral sclerosis (HP:0007354)1.68334301
192Lower limb hyperreflexia (HP:0002395)1.68016061
193Cerebral ischemia (HP:0002637)1.67037924
194Asplenia (HP:0001746)1.66132737
195Severe combined immunodeficiency (HP:0004430)1.66028014
196Aplasia/Hypoplasia of the spleen (HP:0010451)1.65919006
197Abnormal rod and cone electroretinograms (HP:0008323)1.65721245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.89572879
2EPHA34.75003349
3KIT4.03280503
4FLT33.97990915
5TEC3.56822836
6RIPK43.24277763
7PDGFRA2.86976626
8NTRK32.84983770
9TAOK32.76531265
10TIE12.70427494
11LATS22.41493287
12SIK12.34622841
13CSF1R2.33211322
14LATS12.29644602
15FES2.24059250
16EPHA42.22907337
17SYK2.20750623
18BMPR22.01657519
19PLK21.94050798
20BTK1.93644959
21CASK1.93254308
22FGFR21.91991270
23PIK3CG1.79958211
24MAP2K41.77540239
25MAP3K41.77408596
26TTN1.74393178
27STK241.73597718
28PRKD31.71888019
29TXK1.57724067
30NTRK11.54491090
31MAP4K11.53733319
32ERBB41.52954749
33ZAK1.50938616
34PINK11.48039118
35IRAK11.46056958
36PTK2B1.45052679
37FER1.43299482
38FRK1.42144536
39FGFR11.38675159
40PAK61.37835952
41ERBB31.35736897
42TRIB31.30858782
43JAK31.30136310
44PIK3CA1.29608719
45BMPR1B1.28745654
46MAP3K131.27649483
47MINK11.26904930
48MAP3K141.26227704
49NUAK11.24316406
50ITK1.23103156
51MAP2K71.22768382
52AKT31.20774257
53MAP3K91.20249416
54HCK1.19284207
55DMPK1.17503545
56CAMK1G1.15411510
57IKBKB1.15347752
58EPHB21.15323175
59TNK21.14734389
60DAPK21.10835082
61RIPK11.08825314
62PRKCH1.07502444
63HIPK21.05763479
64MUSK1.04679419
65ADRBK21.03350939
66WNK11.02954668
67PHKG11.01088374
68PHKG21.01088374
69KSR11.00082060
70LYN0.95217374
71PDK30.94249717
72PDK40.94249717
73PRKCE0.90410265
74RET0.89749455
75NTRK20.87737611
76BMX0.87248904
77PAK30.86063489
78CDK120.85941684
79PDGFRB0.85261763
80MATK0.84675350
81OBSCN0.81765727
82MAP3K50.81503718
83CAMK1D0.79394943
84ROCK10.79191538
85ALK0.79160349
86ARAF0.78758351
87PDK10.77033341
88YES10.76410611
89CDK60.75913222
90LCK0.75827971
91PRKCQ0.75464932
92CDK90.74182487
93SGK30.73659955
94MAPK130.72419241
95MKNK20.71723006
96MKNK10.71674245
97PRKCG0.71532900
98BCKDK0.70600152
99PTK20.69844305
100NEK90.68572134
101TBK10.66464226
102BLK0.64750309
103CDK80.64180573
104STK30.63686763
105PKN20.63117534
106SGK20.62968987
107PAK20.62920238
108GRK60.62163400
109BRD40.62023563
110GRK50.61186765
111TYRO30.59115278
112ZAP700.56691735
113MAP2K30.56534274
114RPS6KA60.55433679
115CDK50.54479451
116CDC42BPA0.53871537
117RPS6KL10.53157650
118RPS6KC10.53157650
119PNCK0.51903651
120STK380.50650815
121MAP3K70.50572244
122CAMK2A0.50528239
123ATR0.50182094
124JAK20.49772095
125SGK4940.49438581
126SGK2230.49438581
127MET0.48685446
128TGFBR10.48123577
129IGF1R0.48069599
130STK38L0.47187808
131PRPF4B0.47159132
132SIK20.46694190
133RPS6KB20.44874698
134PTK60.44189937
135LMTK20.44099639
136INSRR0.43512322
137ROCK20.42125547
138MAP4K20.42124608
139MAP3K60.41997896
140MARK30.41962587
141CAMKK10.41901230
142STK390.41643014
143SRC0.41520842
144ABL10.41416120
145EEF2K0.41222787
146IKBKE0.40102908
147ERBB20.39918145
148IRAK20.39341738
149MAPK40.39199512
150MAPK120.39000963
151MAPK30.38551948
152TNIK0.38071832
153RPS6KA40.37736271
154MOS0.37190353
155KDR0.36373540
156WNK40.36185604
157PRKD20.35799295
158KSR20.35716865
159EIF2AK20.34318529
160MTOR0.34246386
161MAPK70.34146014
162CAMK10.34114073
163TRPM70.34040905
164MAPK100.34022533
165DYRK1A0.33505334
166CCNB10.33365356
167PRKG10.32657835
168PRKCZ0.31583964
169CSNK1A1L0.31317337
170ADRBK10.31301114
171PKN10.30885190
172SGK10.30531772
173FGFR30.30278881
174INSR0.30164034
175CAMK40.30091697

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.55746421
2ECM-receptor interaction_Homo sapiens_hsa045122.98240257
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.70261488
4Allograft rejection_Homo sapiens_hsa053302.48756745
5Systemic lupus erythematosus_Homo sapiens_hsa053222.38397757
6Primary immunodeficiency_Homo sapiens_hsa053402.26368491
7Graft-versus-host disease_Homo sapiens_hsa053322.20913613
8Nicotine addiction_Homo sapiens_hsa050332.13545189
9Autoimmune thyroid disease_Homo sapiens_hsa053202.13331483
10Basal cell carcinoma_Homo sapiens_hsa052172.11204273
11Dilated cardiomyopathy_Homo sapiens_hsa054142.00442037
12Long-term depression_Homo sapiens_hsa047301.96102982
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.95860485
14* Protein digestion and absorption_Homo sapiens_hsa049741.94542828
15Focal adhesion_Homo sapiens_hsa045101.88667049
16B cell receptor signaling pathway_Homo sapiens_hsa046621.87905005
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86346280
18Leishmaniasis_Homo sapiens_hsa051401.83996585
19Hedgehog signaling pathway_Homo sapiens_hsa043401.83295368
20Staphylococcus aureus infection_Homo sapiens_hsa051501.73010762
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71578172
22Type I diabetes mellitus_Homo sapiens_hsa049401.70262913
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70225718
24Circadian entrainment_Homo sapiens_hsa047131.61864050
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.60068346
26Melanogenesis_Homo sapiens_hsa049161.59991730
27Synaptic vesicle cycle_Homo sapiens_hsa047211.59636793
28Hematopoietic cell lineage_Homo sapiens_hsa046401.59509594
29GABAergic synapse_Homo sapiens_hsa047271.58884378
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55564267
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53181706
32Olfactory transduction_Homo sapiens_hsa047401.51594778
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49692529
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48916017
35Morphine addiction_Homo sapiens_hsa050321.44025106
36Wnt signaling pathway_Homo sapiens_hsa043101.42474713
37Melanoma_Homo sapiens_hsa052181.37233224
38Proteoglycans in cancer_Homo sapiens_hsa052051.37045090
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34820546
40Axon guidance_Homo sapiens_hsa043601.33452303
41Hippo signaling pathway_Homo sapiens_hsa043901.32637917
42Glioma_Homo sapiens_hsa052141.31926611
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.31039383
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29899693
45Antigen processing and presentation_Homo sapiens_hsa046121.29844284
46Gastric acid secretion_Homo sapiens_hsa049711.24956710
47Salivary secretion_Homo sapiens_hsa049701.24501122
48Insulin secretion_Homo sapiens_hsa049111.23116130
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22793196
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22397458
51Glutamatergic synapse_Homo sapiens_hsa047241.21535495
52Oxytocin signaling pathway_Homo sapiens_hsa049211.20989268
53TGF-beta signaling pathway_Homo sapiens_hsa043501.19554988
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18811311
55Dopaminergic synapse_Homo sapiens_hsa047281.18580019
56Long-term potentiation_Homo sapiens_hsa047201.18492315
57Amphetamine addiction_Homo sapiens_hsa050311.16907175
58Alcoholism_Homo sapiens_hsa050341.16659815
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16168024
60Ovarian steroidogenesis_Homo sapiens_hsa049131.16081576
61GnRH signaling pathway_Homo sapiens_hsa049121.15357013
62Calcium signaling pathway_Homo sapiens_hsa040201.14896957
63Amoebiasis_Homo sapiens_hsa051461.14247149
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13833614
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13245409
66Cholinergic synapse_Homo sapiens_hsa047251.11979225
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10148274
68Acute myeloid leukemia_Homo sapiens_hsa052211.09362692
69Gap junction_Homo sapiens_hsa045401.08411852
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07023476
71Rheumatoid arthritis_Homo sapiens_hsa053231.04741822
72Estrogen signaling pathway_Homo sapiens_hsa049151.02184150
73PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02168534
74Phototransduction_Homo sapiens_hsa047441.01616442
75Type II diabetes mellitus_Homo sapiens_hsa049301.01119265
76Jak-STAT signaling pathway_Homo sapiens_hsa046301.00586116
77Renin secretion_Homo sapiens_hsa049241.00570370
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98400357
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97105612
80Prostate cancer_Homo sapiens_hsa052150.96213433
81Thyroid hormone synthesis_Homo sapiens_hsa049180.96127033
82Tuberculosis_Homo sapiens_hsa051520.94848587
83Arachidonic acid metabolism_Homo sapiens_hsa005900.94373635
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94012754
85Rap1 signaling pathway_Homo sapiens_hsa040150.93609131
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93144900
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92421102
88cAMP signaling pathway_Homo sapiens_hsa040240.92404573
89Non-homologous end-joining_Homo sapiens_hsa034500.92267399
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91783512
91African trypanosomiasis_Homo sapiens_hsa051430.90848054
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90549586
93Ether lipid metabolism_Homo sapiens_hsa005650.90100689
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89341943
95Adherens junction_Homo sapiens_hsa045200.88806110
96Nitrogen metabolism_Homo sapiens_hsa009100.88360020
97Viral myocarditis_Homo sapiens_hsa054160.88230975
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86400893
99Pancreatic secretion_Homo sapiens_hsa049720.86026233
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.84161159
101Glycerolipid metabolism_Homo sapiens_hsa005610.83507306
102Viral carcinogenesis_Homo sapiens_hsa052030.83074737
103Linoleic acid metabolism_Homo sapiens_hsa005910.83020522
104MicroRNAs in cancer_Homo sapiens_hsa052060.82127639
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81745364
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81709330
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.81567633
108Osteoclast differentiation_Homo sapiens_hsa043800.81396105
109Glucagon signaling pathway_Homo sapiens_hsa049220.78602691
110Serotonergic synapse_Homo sapiens_hsa047260.78531399
111Vibrio cholerae infection_Homo sapiens_hsa051100.78176673
112Cocaine addiction_Homo sapiens_hsa050300.77838231
113Toxoplasmosis_Homo sapiens_hsa051450.77304929
114Influenza A_Homo sapiens_hsa051640.75743487
115MAPK signaling pathway_Homo sapiens_hsa040100.75563757
116Herpes simplex infection_Homo sapiens_hsa051680.75504049
117Taste transduction_Homo sapiens_hsa047420.73203635
118Prolactin signaling pathway_Homo sapiens_hsa049170.73004760
119Cardiac muscle contraction_Homo sapiens_hsa042600.72222465
120Ras signaling pathway_Homo sapiens_hsa040140.71168558
121ErbB signaling pathway_Homo sapiens_hsa040120.70840562
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70065043
123Dorso-ventral axis formation_Homo sapiens_hsa043200.69753449
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69117232
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68768063
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.68116868
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67658701
128Pathways in cancer_Homo sapiens_hsa052000.67486719
129Chemokine signaling pathway_Homo sapiens_hsa040620.66909553
130mTOR signaling pathway_Homo sapiens_hsa041500.66874919
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63772170
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.63007967
133Colorectal cancer_Homo sapiens_hsa052100.62994526
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62506579
135Collecting duct acid secretion_Homo sapiens_hsa049660.60297584
136Butanoate metabolism_Homo sapiens_hsa006500.60070190
137Insulin resistance_Homo sapiens_hsa049310.59544619
138Chronic myeloid leukemia_Homo sapiens_hsa052200.59477371
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59218571
140Endometrial cancer_Homo sapiens_hsa052130.59031425
141TNF signaling pathway_Homo sapiens_hsa046680.57500326
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56584303
143Non-small cell lung cancer_Homo sapiens_hsa052230.56483344
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55456129
145Oocyte meiosis_Homo sapiens_hsa041140.54831994
146Insulin signaling pathway_Homo sapiens_hsa049100.54412656
147Pancreatic cancer_Homo sapiens_hsa052120.53447349
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53434769
149T cell receptor signaling pathway_Homo sapiens_hsa046600.53352991
150Platelet activation_Homo sapiens_hsa046110.53169871
151Bile secretion_Homo sapiens_hsa049760.51882139
152Malaria_Homo sapiens_hsa051440.51229615
153Bladder cancer_Homo sapiens_hsa052190.50909017
154Base excision repair_Homo sapiens_hsa034100.50854563
155AMPK signaling pathway_Homo sapiens_hsa041520.50462705
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.50435622
157Steroid hormone biosynthesis_Homo sapiens_hsa001400.49797769
158Choline metabolism in cancer_Homo sapiens_hsa052310.49553874
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45859952
160Phagosome_Homo sapiens_hsa041450.43126233
161Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40986355
162Measles_Homo sapiens_hsa051620.39948472
163Neurotrophin signaling pathway_Homo sapiens_hsa047220.38741152
164Leukocyte transendothelial migration_Homo sapiens_hsa046700.37773283

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