COL25A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.98883200
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.67555527
3neuron cell-cell adhesion (GO:0007158)5.53977489
4synaptic vesicle exocytosis (GO:0016079)5.31882443
5nuclear pore complex assembly (GO:0051292)5.17951944
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10947315
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04748683
8chromosome condensation (GO:0030261)5.04040217
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84062779
10regulation of glutamate receptor signaling pathway (GO:1900449)4.81012092
11DNA packaging (GO:0006323)4.79845141
12protein localization to synapse (GO:0035418)4.74721742
13acrosome reaction (GO:0007340)4.70744045
14microtubule depolymerization (GO:0007019)4.68331174
15glutamate secretion (GO:0014047)4.67608210
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.65029411
17locomotory exploration behavior (GO:0035641)4.62450290
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.62169745
19neurotransmitter secretion (GO:0007269)4.45969156
20sperm motility (GO:0030317)4.45115805
21nuclear pore organization (GO:0006999)4.45101150
22synaptic vesicle maturation (GO:0016188)4.42800321
23regulation of centriole replication (GO:0046599)4.40496404
24response to pheromone (GO:0019236)4.32366482
25regulation of synaptic vesicle exocytosis (GO:2000300)4.27437710
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17807708
27exploration behavior (GO:0035640)4.15828713
28positive regulation of vascular permeability (GO:0043117)4.11651058
29neuron-neuron synaptic transmission (GO:0007270)4.08064502
30glutamate receptor signaling pathway (GO:0007215)4.05818980
31fusion of sperm to egg plasma membrane (GO:0007342)4.04489680
32notochord development (GO:0030903)4.04209829
33midgut development (GO:0007494)4.02244522
34regulation of neuronal synaptic plasticity (GO:0048168)3.99835098
35regulation of synaptic vesicle transport (GO:1902803)3.98321984
36neurotransmitter transport (GO:0006836)3.95585912
37neuronal action potential propagation (GO:0019227)3.93623434
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.93528224
39gamma-aminobutyric acid transport (GO:0015812)3.91044292
40proline transport (GO:0015824)3.90149959
41synaptic transmission, glutamatergic (GO:0035249)3.87127541
42spermatid development (GO:0007286)3.85084903
43neuron recognition (GO:0008038)3.83157188
44negative regulation of vascular permeability (GO:0043116)3.81664979
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80204533
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.77315844
47microtubule polymerization or depolymerization (GO:0031109)3.75905799
48startle response (GO:0001964)3.74379339
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72716840
50regulation of neurotransmitter levels (GO:0001505)3.70424678
51single strand break repair (GO:0000012)3.66272973
52transmission of nerve impulse (GO:0019226)3.65603512
53spermatid nucleus differentiation (GO:0007289)3.65441762
54pore complex assembly (GO:0046931)3.64058222
55long-term memory (GO:0007616)3.64041280
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64019653
57paraxial mesoderm development (GO:0048339)3.63305997
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.56856708
59regulation of synapse structural plasticity (GO:0051823)3.55314295
60neurotransmitter-gated ion channel clustering (GO:0072578)3.54807764
61presynaptic membrane assembly (GO:0097105)3.53403595
62binding of sperm to zona pellucida (GO:0007339)3.53175567
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52706528
64negative regulation of neurotransmitter transport (GO:0051589)3.50030984
65synaptic transmission, dopaminergic (GO:0001963)3.47580509
66mating behavior (GO:0007617)3.47048122
67dendritic spine morphogenesis (GO:0060997)3.46995216
68response to histamine (GO:0034776)3.46890060
69postsynaptic membrane organization (GO:0001941)3.46767964
70sperm capacitation (GO:0048240)3.46452014
71sperm-egg recognition (GO:0035036)3.46251758
72regulation of postsynaptic membrane potential (GO:0060078)3.44363725
73synaptic vesicle docking involved in exocytosis (GO:0016081)3.43492344
74neuromuscular process controlling posture (GO:0050884)3.43454245
75behavioral response to cocaine (GO:0048148)3.43237253
76dopamine transport (GO:0015872)3.42635321
77positive regulation of membrane potential (GO:0045838)3.41750460
78plasma membrane fusion (GO:0045026)3.41051792
79synaptic vesicle endocytosis (GO:0048488)3.37349247
80dopamine biosynthetic process (GO:0042416)3.35911584
81outer ear morphogenesis (GO:0042473)3.32626565
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.29790741
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28566504
84righting reflex (GO:0060013)3.27536306
85axonal fasciculation (GO:0007413)3.27113018
86synapse assembly (GO:0007416)3.25049799
87presynaptic membrane organization (GO:0097090)3.24330427
88positive regulation of synapse assembly (GO:0051965)3.23722113
89cAMP catabolic process (GO:0006198)3.22996966
90collagen fibril organization (GO:0030199)3.22930170
91regulation of vesicle fusion (GO:0031338)3.22383580
92prepulse inhibition (GO:0060134)3.21952687
93response to auditory stimulus (GO:0010996)3.21842682
94regulation of synaptic transmission, GABAergic (GO:0032228)3.21640353
95membrane hyperpolarization (GO:0060081)3.18595530
96layer formation in cerebral cortex (GO:0021819)3.17662878
97centriole replication (GO:0007099)3.15914405
98glomerular visceral epithelial cell development (GO:0072015)3.13735536
99response to cocaine (GO:0042220)3.13633189
100long-term synaptic potentiation (GO:0060291)3.11602023
101regulation of respiratory system process (GO:0044065)3.11501368
102social behavior (GO:0035176)3.10703520
103intraspecies interaction between organisms (GO:0051703)3.10703520
104regulation of synaptic plasticity (GO:0048167)3.10488381
105cellular potassium ion homeostasis (GO:0030007)3.10052825
106cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.09215956
107positive regulation of synapse maturation (GO:0090129)3.07890109
108catecholamine transport (GO:0051937)3.07494736
109regulation of catecholamine metabolic process (GO:0042069)3.07464258
110regulation of dopamine metabolic process (GO:0042053)3.07464258
111cellular response to ammonium ion (GO:0071242)3.06101234
112membrane depolarization (GO:0051899)3.05459538
113regulation of neurotransmitter transport (GO:0051588)3.04721418
114neurotransmitter biosynthetic process (GO:0042136)3.03671487
115learning (GO:0007612)3.03062864
116behavioral response to ethanol (GO:0048149)3.02333631
117regulation of neurotransmitter secretion (GO:0046928)3.02183052
118regulation of glutamate secretion (GO:0014048)3.01554673
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01389209
120activation of protein kinase A activity (GO:0034199)3.00809820
121mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.00350866
122positive regulation of neurotransmitter transport (GO:0051590)2.97944733
123cerebellar Purkinje cell differentiation (GO:0021702)2.97317076
124membrane depolarization during action potential (GO:0086010)2.96859772
125synaptic transmission (GO:0007268)2.96743817
126auditory behavior (GO:0031223)2.96442831
127regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96113587
128regulation of dendritic spine morphogenesis (GO:0061001)2.95206034
129synaptic vesicle transport (GO:0048489)2.94963283
130establishment of synaptic vesicle localization (GO:0097480)2.94963283
131innervation (GO:0060384)2.94956359
132microtubule severing (GO:0051013)2.91998852
133positive regulation of endothelial cell differentiation (GO:0045603)2.91213821
134musculoskeletal movement (GO:0050881)2.90169983
135multicellular organismal movement (GO:0050879)2.90169983
136embryonic skeletal joint morphogenesis (GO:0060272)2.84828523
137rRNA methylation (GO:0031167)2.83319475
138cyclic nucleotide catabolic process (GO:0009214)2.82737866
139metanephric mesenchyme development (GO:0072075)2.81574461
140protein polyglutamylation (GO:0018095)2.79435274
141peptidyl-proline hydroxylation (GO:0019511)2.79192044
142regulation of centrosome duplication (GO:0010824)2.78219883
143glomerular epithelial cell development (GO:0072310)2.77056926
144spermatogenesis (GO:0007283)2.75397192
145male gamete generation (GO:0048232)2.74998966
146cGMP-mediated signaling (GO:0019934)2.74254129
147DNA conformation change (GO:0071103)2.70703987
148calcium ion-dependent exocytosis (GO:0017156)2.67895656
149dorsal/ventral axis specification (GO:0009950)2.66742026
150skeletal muscle organ development (GO:0060538)2.66558036
151generation of neurons (GO:0048699)2.62101202
152nucleus organization (GO:0006997)2.61897212
153cell-cell recognition (GO:0009988)2.60290316
154muscle cell fate commitment (GO:0042693)2.58624205
155myoblast fusion (GO:0007520)2.57647419
156embryonic camera-type eye development (GO:0031076)2.56863804
157neuron projection extension involved in neuron projection guidance (GO:1902284)2.56198269
158axon extension involved in axon guidance (GO:0048846)2.56198269
159glomerular basement membrane development (GO:0032836)2.55961539
160appendage development (GO:0048736)2.55766385
161limb development (GO:0060173)2.55766385
162kidney mesenchyme development (GO:0072074)2.55535932
163regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.55041049
164centrosome duplication (GO:0051298)2.54424651
165centriole assembly (GO:0098534)2.53229290
166genitalia morphogenesis (GO:0035112)2.52936422
167gamete generation (GO:0007276)2.52843198
168multicellular organism reproduction (GO:0032504)2.52476290
169nucleosome disassembly (GO:0006337)2.51298643
170protein-DNA complex disassembly (GO:0032986)2.51298643
171negative chemotaxis (GO:0050919)2.50735660
172DNA unwinding involved in DNA replication (GO:0006268)2.50106951
173regulation of centrosome cycle (GO:0046605)2.49372918
174mitotic sister chromatid cohesion (GO:0007064)2.42953722
175artery development (GO:0060840)2.42045241
176DNA synthesis involved in DNA repair (GO:0000731)2.39898989
177hippo signaling (GO:0035329)2.39137400
178non-recombinational repair (GO:0000726)2.37310714
179double-strand break repair via nonhomologous end joining (GO:0006303)2.37310714
180regulation of vascular permeability (GO:0043114)2.32411112
181germ cell development (GO:0007281)2.31965638
182diaphragm development (GO:0060539)2.31603289
183embryonic body morphogenesis (GO:0010172)2.31391399
184positive regulation of Rab GTPase activity (GO:0032851)2.30873109
185regulation of Rab GTPase activity (GO:0032313)2.30873109
186reproduction (GO:0000003)2.30314161
187* collagen catabolic process (GO:0030574)2.29695584
188regulation of transcription involved in cell fate commitment (GO:0060850)2.29060482
189chromatin silencing (GO:0006342)2.28308552
190cell migration involved in sprouting angiogenesis (GO:0002042)2.28023112
191negative regulation of inclusion body assembly (GO:0090084)2.27362341
192proximal/distal pattern formation (GO:0009954)2.26742471
193regulation of cardioblast differentiation (GO:0051890)2.26739134
194establishment of apical/basal cell polarity (GO:0035089)2.26697020
195protein hydroxylation (GO:0018126)2.25716713
196lung-associated mesenchyme development (GO:0060484)2.25457960
197cellular process involved in reproduction in multicellular organism (GO:0022412)2.24375993
198* collagen metabolic process (GO:0032963)2.22620850
199histone exchange (GO:0043486)2.22449510
200rRNA modification (GO:0000154)2.21982971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88002655
2E2F7_22180533_ChIP-Seq_HELA_Human5.09178682
3GBX2_23144817_ChIP-Seq_PC3_Human3.98156791
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09221308
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04751124
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99524801
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.71878216
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71087330
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65147104
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60028538
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60028538
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57672591
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56476127
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54597688
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53803916
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.51188648
17TAF15_26573619_Chip-Seq_HEK293_Human2.51095191
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.46708884
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39607713
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33493977
21REST_21632747_ChIP-Seq_MESCs_Mouse2.29106030
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28481424
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11815680
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.07191410
25DROSHA_22980978_ChIP-Seq_HELA_Human2.06317250
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.06295883
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04924843
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04170960
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04023253
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97658567
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.96280032
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.95004436
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94055993
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90088051
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83929143
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80987846
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.80974204
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.79965524
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.79296980
40IGF1R_20145208_ChIP-Seq_DFB_Human1.78790403
41P300_19829295_ChIP-Seq_ESCs_Human1.72834454
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72533071
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71447173
44AR_21572438_ChIP-Seq_LNCaP_Human1.70391485
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.67469768
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62860358
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61904026
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58659537
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58531892
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57501577
51SOX9_26525672_Chip-Seq_HEART_Mouse1.54901185
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54813307
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.54781605
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53915260
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51443914
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.49604717
57FUS_26573619_Chip-Seq_HEK293_Human1.49490476
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49176002
59CBP_20019798_ChIP-Seq_JUKART_Human1.49176002
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.47244672
61ZNF274_21170338_ChIP-Seq_K562_Hela1.44715788
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39050518
63EWS_26573619_Chip-Seq_HEK293_Human1.38520409
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37571857
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37387863
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36042410
67STAT3_23295773_ChIP-Seq_U87_Human1.36004029
68RNF2_27304074_Chip-Seq_NSC_Mouse1.35360423
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.34454698
70AR_25329375_ChIP-Seq_VCAP_Human1.31382059
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29788088
72* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28045271
73* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27281760
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24815717
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.24297667
76TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23464369
77* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22915599
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.22479192
79TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21877724
80TBL1_22424771_ChIP-Seq_293T_Human1.21874442
81VDR_22108803_ChIP-Seq_LS180_Human1.19211060
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18523077
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18441391
84* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18108329
85TP53_18474530_ChIP-ChIP_U2OS_Human1.17380428
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17223701
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16760782
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.16302155
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16183164
90* NANOG_18555785_Chip-Seq_ESCs_Mouse1.15992469
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15932702
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14299311
93TCF4_23295773_ChIP-Seq_U87_Human1.14209814
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14189275
95AR_19668381_ChIP-Seq_PC3_Human1.13899562
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13801780
97* RUNX2_22187159_ChIP-Seq_PCA_Human1.13640940
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13103268
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.12826537
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10537580
101NFYB_21822215_ChIP-Seq_K562_Human1.08808309
102* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07979126
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.07113185
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06656976
105ER_23166858_ChIP-Seq_MCF-7_Human1.06617817
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.05813169
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05544745
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04844707
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04150069
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03984218
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.03808913
112JUN_21703547_ChIP-Seq_K562_Human1.03748335
113BCAT_22108803_ChIP-Seq_LS180_Human1.03504452
114TP53_16413492_ChIP-PET_HCT116_Human1.03460682
115CJUN_26792858_Chip-Seq_BT549_Human1.03182018
116FLI1_27457419_Chip-Seq_LIVER_Mouse1.03181082
117* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02607428
118AHR_22903824_ChIP-Seq_MCF-7_Human1.02252776
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02241373
120SMAD3_21741376_ChIP-Seq_ESCs_Human1.01709726
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01233832
122PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00960524
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.00658303
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00360164
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98296612
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.98025773
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.97170441
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97058270
129* P53_22387025_ChIP-Seq_ESCs_Mouse0.96869585
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.96737543
131KDM2B_26808549_Chip-Seq_REH_Human0.96301522
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96009260
133* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94954315
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.94510413
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94309907
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93760906
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93760906
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.92629342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.32184706
2MP0003880_abnormal_central_pattern5.20790017
3MP0008438_abnormal_cutaneous_collagen3.94800607
4MP0003635_abnormal_synaptic_transmissio3.90335500
5MP0009745_abnormal_behavioral_response3.39475327
6MP0009046_muscle_twitch3.25780103
7MP0005503_abnormal_tendon_morphology3.25519757
8MP0005410_abnormal_fertilization3.23804946
9MP0002064_seizures3.16242740
10MP0005275_abnormal_skin_tensile3.10204914
11MP0005423_abnormal_somatic_nervous3.07280062
12MP0002063_abnormal_learning/memory/cond3.03175052
13MP0001501_abnormal_sleep_pattern3.01673412
14MP0001968_abnormal_touch/_nociception2.89153918
15MP0002572_abnormal_emotion/affect_behav2.84259722
16MP0002822_catalepsy2.82894529
17MP0006276_abnormal_autonomic_nervous2.67783899
18MP0002272_abnormal_nervous_system2.63760695
19MP0004270_analgesia2.59046738
20MP0010030_abnormal_orbit_morphology2.54504162
21MP0001486_abnormal_startle_reflex2.53358723
22MP0004272_abnormal_basement_membrane2.50798083
23MP0002736_abnormal_nociception_after2.31463880
24MP0005645_abnormal_hypothalamus_physiol2.28075730
25MP0003122_maternal_imprinting2.26055938
26MP0001529_abnormal_vocalization2.24875578
27MP0002735_abnormal_chemical_nociception2.21382401
28MP0003705_abnormal_hypodermis_morpholog2.18351519
29MP0000049_abnormal_middle_ear2.18180906
30MP0001440_abnormal_grooming_behavior2.17518175
31MP0002734_abnormal_mechanical_nocicepti2.14783102
32MP0001905_abnormal_dopamine_level2.02551085
33MP0008057_abnormal_DNA_replication1.97523522
34MP0002067_abnormal_sensory_capabilities1.97487196
35MP0009053_abnormal_anal_canal1.92286328
36MP0003937_abnormal_limbs/digits/tail_de1.87505908
37MP0001188_hyperpigmentation1.86729500
38MP0005386_behavior/neurological_phenoty1.86350053
39MP0004924_abnormal_behavior1.86350053
40MP0002557_abnormal_social/conspecific_i1.85568334
41MP0002184_abnormal_innervation1.84254155
42MP0002733_abnormal_thermal_nociception1.83783175
43MP0002697_abnormal_eye_size1.81680820
44MP0000534_abnormal_ureter_morphology1.79698474
45MP0003878_abnormal_ear_physiology1.79546836
46MP0005377_hearing/vestibular/ear_phenot1.79546836
47MP0004233_abnormal_muscle_weight1.77649639
48MP0005646_abnormal_pituitary_gland1.76799750
49MP0001970_abnormal_pain_threshold1.75008524
50MP0003787_abnormal_imprinting1.74823178
51MP0003942_abnormal_urinary_system1.72524993
52MP0000537_abnormal_urethra_morphology1.62444020
53MP0000778_abnormal_nervous_system1.60179559
54MP0003879_abnormal_hair_cell1.60081630
55MP0004142_abnormal_muscle_tone1.58769777
56MP0001299_abnormal_eye_distance/1.50851765
57MP0002108_abnormal_muscle_morphology1.50373590
58MP0003698_abnormal_male_reproductive1.49993733
59MP0004858_abnormal_nervous_system1.48203815
60MP0002234_abnormal_pharynx_morphology1.47372077
61MP0005670_abnormal_white_adipose1.47284553
62MP0003119_abnormal_digestive_system1.46321462
63MP0008569_lethality_at_weaning1.41797597
64MP0002249_abnormal_larynx_morphology1.40056478
65MP0004811_abnormal_neuron_physiology1.38241957
66MP0001286_abnormal_eye_development1.37170496
67MP0010368_abnormal_lymphatic_system1.36950375
68MP0000569_abnormal_digit_pigmentation1.36865051
69MP0000955_abnormal_spinal_cord1.35895749
70MP0010386_abnormal_urinary_bladder1.35634397
71MP0009780_abnormal_chondrocyte_physiolo1.35600303
72MP0003077_abnormal_cell_cycle1.34283274
73MP0001929_abnormal_gametogenesis1.33701521
74MP0001293_anophthalmia1.32484099
75MP0002909_abnormal_adrenal_gland1.32374095
76MP0009697_abnormal_copulation1.31916345
77MP0002066_abnormal_motor_capabilities/c1.30508930
78MP0005187_abnormal_penis_morphology1.30253688
79MP0001984_abnormal_olfaction1.29476895
80MP0002882_abnormal_neuron_morphology1.27992600
81MP0001348_abnormal_lacrimal_gland1.26773422
82MP0002092_abnormal_eye_morphology1.25068239
83MP0001502_abnormal_circadian_rhythm1.24907629
84MP0000428_abnormal_craniofacial_morphol1.24774826
85MP0003329_amyloid_beta_deposits1.24288974
86MP0010094_abnormal_chromosome_stability1.23817665
87MP0003935_abnormal_craniofacial_develop1.22230422
88MP0003755_abnormal_palate_morphology1.22158077
89MP0009250_abnormal_appendicular_skeleto1.21121425
90MP0008932_abnormal_embryonic_tissue1.20687751
91MP0004885_abnormal_endolymph1.17060824
92MP0005409_darkened_coat_color1.15941933
93MP0001879_abnormal_lymphatic_vessel1.14533698
94MP0005248_abnormal_Harderian_gland1.13199977
95MP0008872_abnormal_physiological_respon1.12714218
96MP0000733_abnormal_muscle_development1.10986722
97MP0003136_yellow_coat_color1.08889778
98MP0002282_abnormal_trachea_morphology1.08618664
99MP0005391_vision/eye_phenotype1.08508307
100MP0002084_abnormal_developmental_patter1.08181074
101MP0002233_abnormal_nose_morphology1.08167050
102MP0004957_abnormal_blastocyst_morpholog1.07617253
103MP0002938_white_spotting1.06076075
104MP0002837_dystrophic_cardiac_calcinosis1.05864391
105MP0000678_abnormal_parathyroid_gland1.04671130
106MP0006054_spinal_hemorrhage1.04515908
107MP0002085_abnormal_embryonic_tissue1.04110457
108MP0010352_gastrointestinal_tract_polyps1.03466364
109MP0004145_abnormal_muscle_electrophysio1.01060022
110MP0003633_abnormal_nervous_system1.00566551
111MP0003861_abnormal_nervous_system1.00198117
112MP0006292_abnormal_olfactory_placode0.99853202
113MP0001177_atelectasis0.99589259
114MP0001661_extended_life_span0.99379185
115MP0000762_abnormal_tongue_morphology0.99190228
116MP0004742_abnormal_vestibular_system0.99167390
117MP0003693_abnormal_embryo_hatching0.98546788
118MP0000631_abnormal_neuroendocrine_gland0.97583194
119MP0002932_abnormal_joint_morphology0.97215138
120MP0001963_abnormal_hearing_physiology0.95598573
121MP0005535_abnormal_body_temperature0.95293532
122MP0002161_abnormal_fertility/fecundity0.95132208
123MP0002116_abnormal_craniofacial_bone0.94993744
124MP0003941_abnormal_skin_development0.94735201
125MP0001664_abnormal_digestion0.94020400
126MP0002152_abnormal_brain_morphology0.93780012
127MP0003111_abnormal_nucleus_morphology0.93429221
128MP0000432_abnormal_head_morphology0.92944880
129MP0003631_nervous_system_phenotype0.91942760
130MP0003121_genomic_imprinting0.90698674
131MP0005367_renal/urinary_system_phenotyp0.89854326
132MP0000516_abnormal_urinary_system0.89854326
133MP0005551_abnormal_eye_electrophysiolog0.89561743
134MP0003123_paternal_imprinting0.88978689
135MP0000751_myopathy0.88034309
136MP0004484_altered_response_of0.85992296
137MP0002069_abnormal_eating/drinking_beha0.85962436
138MP0005253_abnormal_eye_physiology0.85638671
139MP0002009_preneoplasia0.85366221
140MP0002114_abnormal_axial_skeleton0.84626746
141MP0008874_decreased_physiological_sensi0.83912391
142MP0002229_neurodegeneration0.83295441
143MP0000003_abnormal_adipose_tissue0.82919567
144MP0002081_perinatal_lethality0.82624943
145MP0004085_abnormal_heartbeat0.82518948
146MP0002109_abnormal_limb_morphology0.81899590
147MP0002876_abnormal_thyroid_physiology0.81453813
148MP0001485_abnormal_pinna_reflex0.80369076
149MP0001849_ear_inflammation0.79177540
150MP0002111_abnormal_tail_morphology0.78903539
151MP0002102_abnormal_ear_morphology0.77840085
152MP0000749_muscle_degeneration0.77367379
153MP0003115_abnormal_respiratory_system0.76999244
154MP0005257_abnormal_intraocular_pressure0.76717483
155MP0003890_abnormal_embryonic-extraembry0.76502038
156MP0001672_abnormal_embryogenesis/_devel0.76100070
157MP0005380_embryogenesis_phenotype0.76100070
158MP0003718_maternal_effect0.75410222
159MP0000579_abnormal_nail_morphology0.75009460
160MP0005197_abnormal_uvea_morphology0.74628015
161MP0002210_abnormal_sex_determination0.74096904
162MP0002752_abnormal_somatic_nervous0.73786014
163MP0008058_abnormal_DNA_repair0.72802284
164MP0003632_abnormal_nervous_system0.71964492
165MP0000026_abnormal_inner_ear0.71942268
166MP0003137_abnormal_impulse_conducting0.69375628
167MP0001943_abnormal_respiration0.68069413
168MP0000013_abnormal_adipose_tissue0.67805297
169MP0003646_muscle_fatigue0.67527352
170MP0003634_abnormal_glial_cell0.67456983
171MP0002638_abnormal_pupillary_reflex0.67320617
172MP0005394_taste/olfaction_phenotype0.66740042
173MP0005499_abnormal_olfactory_system0.66740042
174MP0005171_absent_coat_pigmentation0.61687143
175MP0003690_abnormal_glial_cell0.61412979
176MP0005623_abnormal_meninges_morphology0.60195747
177MP0005379_endocrine/exocrine_gland_phen0.56236183
178MP0004215_abnormal_myocardial_fiber0.56055720
179MP0006072_abnormal_retinal_apoptosis0.54588696
180MP0002090_abnormal_vision0.54446331
181MP0004043_abnormal_pH_regulation0.52683842
182MP0000920_abnormal_myelination0.52302544
183MP0003938_abnormal_ear_development0.51870625
184MP0000538_abnormal_urinary_bladder0.48088634
185MP0003385_abnormal_body_wall0.47858500
186MP0005167_abnormal_blood-brain_barrier0.47108321

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.17410887
2Focal seizures (HP:0007359)5.64382199
3Myokymia (HP:0002411)5.45940709
4Visual hallucinations (HP:0002367)5.08515207
5Atonic seizures (HP:0010819)5.02993290
6Febrile seizures (HP:0002373)4.92962506
7Limb dystonia (HP:0002451)4.56664788
8Epileptic encephalopathy (HP:0200134)4.46160556
9Absence seizures (HP:0002121)4.33436253
10Generalized tonic-clonic seizures (HP:0002069)4.33105383
11Progressive cerebellar ataxia (HP:0002073)4.20725217
12Premature rupture of membranes (HP:0001788)4.19608595
13Abnormality of the ischium (HP:0003174)4.08888087
14Dialeptic seizures (HP:0011146)3.85351665
15Hypoplastic ischia (HP:0003175)3.75386444
16Hyperventilation (HP:0002883)3.53787827
17Broad-based gait (HP:0002136)3.46068348
18Calcaneovalgus deformity (HP:0001848)3.45797511
19Deformed tarsal bones (HP:0008119)3.22505755
20Progressive inability to walk (HP:0002505)3.21840931
21Abnormal hair whorl (HP:0010721)3.07446035
22Short 4th metacarpal (HP:0010044)3.03415576
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.03415576
24Thin ribs (HP:0000883)3.00207472
25Abnormality of the calcaneus (HP:0008364)2.97930233
26Atrophic scars (HP:0001075)2.96623527
27Supranuclear gaze palsy (HP:0000605)2.91621664
28Gaze-evoked nystagmus (HP:0000640)2.90501441
29Soft skin (HP:0000977)2.85764191
30Vitreoretinal degeneration (HP:0000655)2.85178625
31Bell-shaped thorax (HP:0001591)2.84655093
32Abnormality of the 4th metacarpal (HP:0010012)2.83530286
33Cerebral inclusion bodies (HP:0100314)2.80980399
34Anxiety (HP:0000739)2.78571858
35Cutaneous finger syndactyly (HP:0010554)2.77612978
36Abnormal eating behavior (HP:0100738)2.76387435
37Excessive salivation (HP:0003781)2.76050915
38Drooling (HP:0002307)2.76050915
39Truncal ataxia (HP:0002078)2.74935849
40Impaired vibration sensation in the lower limbs (HP:0002166)2.71876156
41Neurofibrillary tangles (HP:0002185)2.69915254
42Dysmetria (HP:0001310)2.69740317
43Popliteal pterygium (HP:0009756)2.68937748
44Cutaneous syndactyly (HP:0012725)2.68649409
45Ankle clonus (HP:0011448)2.67711208
46Volvulus (HP:0002580)2.64529257
47Dysdiadochokinesis (HP:0002075)2.64304889
48Fetal akinesia sequence (HP:0001989)2.63856762
49Action tremor (HP:0002345)2.62336014
50Papilledema (HP:0001085)2.62026068
51Renovascular hypertension (HP:0100817)2.61098258
52Bladder diverticulum (HP:0000015)2.61083648
53Pheochromocytoma (HP:0002666)2.60851416
54Depression (HP:0000716)2.59636820
55Absent speech (HP:0001344)2.56895573
56Severe visual impairment (HP:0001141)2.53884000
57Poor eye contact (HP:0000817)2.53308767
58Aortic dissection (HP:0002647)2.53039299
59Polyphagia (HP:0002591)2.52399265
60Postural instability (HP:0002172)2.50958437
61Failure to thrive in infancy (HP:0001531)2.46155277
62Protrusio acetabuli (HP:0003179)2.45864640
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45585945
64Long clavicles (HP:0000890)2.44211078
65Mutism (HP:0002300)2.43352748
66Absent/shortened dynein arms (HP:0200106)2.40326207
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.40326207
68Urinary bladder sphincter dysfunction (HP:0002839)2.38678687
69Amblyopia (HP:0000646)2.37565754
70Abnormal social behavior (HP:0012433)2.37449726
71Impaired social interactions (HP:0000735)2.37449726
72Synostosis of carpal bones (HP:0005048)2.34113784
73Diplopia (HP:0000651)2.33961188
74Abnormality of binocular vision (HP:0011514)2.33961188
75Wide anterior fontanel (HP:0000260)2.33360537
76Bradykinesia (HP:0002067)2.31228261
77Esotropia (HP:0000565)2.27928279
78Ectopia lentis (HP:0001083)2.26360323
79Hemiparesis (HP:0001269)2.25172412
80Inability to walk (HP:0002540)2.24942294
81Neuroendocrine neoplasm (HP:0100634)2.24528046
82Generalized myoclonic seizures (HP:0002123)2.24086719
83Short palpebral fissure (HP:0012745)2.22459480
84Abnormality of the aortic arch (HP:0012303)2.19727488
85Abnormality of dentin (HP:0010299)2.19631264
86Fibular hypoplasia (HP:0003038)2.15638767
87Spastic gait (HP:0002064)2.15287843
88Epileptiform EEG discharges (HP:0011182)2.14397319
89Vertebral clefting (HP:0008428)2.14330185
90Mitral valve prolapse (HP:0001634)2.14295649
91Chromsome breakage (HP:0040012)2.14066207
92Genetic anticipation (HP:0003743)2.10409650
93Scanning speech (HP:0002168)2.09242771
94Peritonitis (HP:0002586)2.08792586
95Gait imbalance (HP:0002141)2.08255142
96Sleep apnea (HP:0010535)2.07995227
97Narrow nasal bridge (HP:0000446)2.07982671
98Hypoventilation (HP:0002791)2.05287569
99Torticollis (HP:0000473)2.05162554
100Ulnar bowing (HP:0003031)2.05159836
101Status epilepticus (HP:0002133)2.03229784
102Gastroesophageal reflux (HP:0002020)2.02873843
103EEG with generalized epileptiform discharges (HP:0011198)2.02374591
104Blue irides (HP:0000635)2.00289781
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.99905709
106Absent epiphyses (HP:0010577)1.99905709
107Abnormality of salivation (HP:0100755)1.99844252
108Malignant hyperthermia (HP:0002047)1.99781139
109Lower limb muscle weakness (HP:0007340)1.99207158
110Agitation (HP:0000713)1.97371964
111Protruding tongue (HP:0010808)1.96640413
112Abnormal ciliary motility (HP:0012262)1.95589733
113Genital tract atresia (HP:0001827)1.94145106
114Abnormality of the corticospinal tract (HP:0002492)1.94026121
115Urinary urgency (HP:0000012)1.93552622
116Focal dystonia (HP:0004373)1.92396245
117Glossoptosis (HP:0000162)1.92332854
118Aplasia involving bones of the extremities (HP:0009825)1.92148577
119Aplasia involving bones of the upper limbs (HP:0009823)1.92148577
120Aplasia of the phalanges of the hand (HP:0009802)1.92148577
121Decreased circulating renin level (HP:0003351)1.91371976
122Fragile skin (HP:0001030)1.90994901
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90905226
124Shallow orbits (HP:0000586)1.89860220
125Type 2 muscle fiber atrophy (HP:0003554)1.89795920
126Vaginal atresia (HP:0000148)1.89504110
127Carpal synostosis (HP:0009702)1.88629554
128Morphological abnormality of the middle ear (HP:0008609)1.88007020
129Abnormality of the right ventricle (HP:0001707)1.87873859
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.87412240
131Midline defect of the nose (HP:0004122)1.86872201
132Hypothermia (HP:0002045)1.86631493
133Aplasia/Hypoplasia of the fibula (HP:0006492)1.85082666
134Psychosis (HP:0000709)1.84004066
135Hypsarrhythmia (HP:0002521)1.83469907
136Hemiplegia (HP:0002301)1.82241980
137Specific learning disability (HP:0001328)1.82214510
138Bony spicule pigmentary retinopathy (HP:0007737)1.81980042
139High anterior hairline (HP:0009890)1.81961053
140Neonatal short-limb short stature (HP:0008921)1.81855958
141Impaired vibratory sensation (HP:0002495)1.80914035
142Congenital primary aphakia (HP:0007707)1.80734294
143Poor suck (HP:0002033)1.80704308
144Omphalocele (HP:0001539)1.79187709
145Osteomalacia (HP:0002749)1.78657424
146Generalized hypopigmentation of hair (HP:0011358)1.78041914
147Insidious onset (HP:0003587)1.77631121
148Termporal pattern (HP:0011008)1.77631121
149Medial flaring of the eyebrow (HP:0010747)1.77410293
150Absent frontal sinuses (HP:0002688)1.77107959
151Muscle fiber atrophy (HP:0100295)1.76542278
152Widely spaced teeth (HP:0000687)1.75481671
153Pterygium (HP:0001059)1.74778776
154Increased corneal curvature (HP:0100692)1.74205872
155Keratoconus (HP:0000563)1.74205872
156Incomplete penetrance (HP:0003829)1.74034539
157Renal duplication (HP:0000075)1.74008022
158Degeneration of the lateral corticospinal tracts (HP:0002314)1.73763443
159Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73763443
160Abnormality of macular pigmentation (HP:0008002)1.73248343
161Abnormality of the ileum (HP:0001549)1.72882898
162Hypoplasia of the iris (HP:0007676)1.71899155
163Bradycardia (HP:0001662)1.71489646
164Akinesia (HP:0002304)1.70268893
165Bowel diverticulosis (HP:0005222)1.70053806
166Broad long bones (HP:0005622)1.68412728
167Hyperextensible skin (HP:0000974)1.67761906
168Abnormality of the pubic bones (HP:0003172)1.67407892
169Breech presentation (HP:0001623)1.67183557
170Transposition of the great arteries (HP:0001669)1.66129872
171Abnormal connection of the cardiac segments (HP:0011545)1.66129872
172Abnormal ventriculo-arterial connection (HP:0011563)1.66129872
173Abnormality of placental membranes (HP:0011409)1.63966321
174Amniotic constriction ring (HP:0009775)1.63966321
175Bifid tongue (HP:0010297)1.61405738
176Arthropathy (HP:0003040)1.59326230
177Synostosis involving bones of the hand (HP:0004278)1.58003292
178Tubulointerstitial nephritis (HP:0001970)1.56570716
179Broad ribs (HP:0000885)1.56563088
180Broad phalanx (HP:0006009)1.55811476
181Limited hip movement (HP:0008800)1.53675240
182Exostoses (HP:0100777)1.53471628
183Ectopic kidney (HP:0000086)1.53086273
184Abdominal situs inversus (HP:0003363)1.52570946
185Abnormality of abdominal situs (HP:0011620)1.52570946
186Chronic hepatic failure (HP:0100626)1.52566906
187Round face (HP:0000311)1.51576992
188Microglossia (HP:0000171)1.51031366
189Skull defect (HP:0001362)1.50919535
190Abnormal delivery (HP:0001787)1.50745118
191Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.50342216
192Retinal detachment (HP:0000541)1.49944542
193Abnormality of the acetabulum (HP:0003170)1.49533826
194Renal dysplasia (HP:0000110)1.48755336
195Scotoma (HP:0000575)1.48572974
196Broad phalanges of the hand (HP:0009768)1.46727382
197Genu recurvatum (HP:0002816)1.46483737
198Tubular atrophy (HP:0000092)1.46409576
199Irregular epiphyses (HP:0010582)1.44465722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.45745173
2PLK44.09123443
3EPHA43.93599383
4MAP3K43.42328983
5MAP2K73.25177063
6STK38L3.23931230
7MAP3K92.84451278
8MAP3K122.82949819
9LATS12.81497767
10CASK2.76319400
11EEF2K2.65778538
12MKNK12.55211628
13TIE12.46013796
14PNCK2.41092369
15BRSK22.29743549
16CDC72.28176666
17MINK12.27661164
18MARK12.16214270
19TNIK2.13298260
20NTRK22.10987175
21MAP2K42.09612752
22BRD42.06336176
23NTRK11.96543576
24ZAK1.95539284
25TTK1.94773862
26PLK21.86272546
27MKNK21.67932058
28PAK61.65888228
29GRK51.64981694
30SRPK11.62190289
31RIPK41.61413373
32CDK121.53147359
33ARAF1.52379913
34CAMK2A1.44147847
35MAPK131.43883495
36CDK51.34920651
37KSR21.34151766
38SIK21.33210101
39MAP3K131.32898134
40EPHB21.31946581
41INSRR1.29507542
42FES1.29029378
43DAPK21.28948401
44PRKCG1.26273881
45KSR11.24443149
46BRSK11.24308258
47STK31.21405464
48CSNK1G21.17694241
49KDR1.17001899
50CAMK1D1.16445710
51TESK11.14478854
52PDK21.12901252
53PRPF4B1.12471068
54CAMKK11.08805081
55BMPR1B1.07068911
56STK381.03507632
57UHMK11.01359642
58CAMK10.98126794
59TTN0.97699981
60CAMK2B0.97121729
61LATS20.95767860
62CDK70.94721107
63FGR0.92736291
64SGK20.92380487
65MAP4K20.91730470
66NEK10.91572863
67BMPR20.91243741
68ADRBK20.90907427
69SGK2230.90677913
70SGK4940.90677913
71PDGFRA0.89755454
72CSNK1G30.89440392
73NME10.89219099
74DAPK10.88946612
75WNK30.88531398
76PAK30.88347168
77PRKD30.88269758
78PTK2B0.88007333
79CHEK20.87231471
80TNK20.86627166
81PBK0.85118345
82PRKCE0.84204900
83CDK190.82483537
84ATR0.82138889
85GRK70.81870960
86CAMK1G0.81020851
87PRKCH0.80549287
88OXSR10.79969483
89MTOR0.79624195
90SIK30.77590713
91SGK10.77509414
92PLK30.77030896
93DYRK1A0.76559293
94MAPKAPK50.75037097
95CAMK2G0.73480564
96STK110.71758295
97ICK0.69971869
98CAMK2D0.68653472
99PLK10.68534221
100CHEK10.68113027
101FER0.67124590
102STK390.67032775
103ACVR1B0.66890211
104CDK180.66050593
105ATM0.65886264
106NEK20.65465122
107PHKG20.65287477
108PHKG10.65287477
109MET0.64164644
110CDK150.62788626
111CDK140.62457423
112CDK10.62448778
113NEK90.62425206
114AKT30.62399029
115CDK20.62084611
116RAF10.61728772
117WEE10.61638767
118SGK30.60958828
119CSNK1G10.60946308
120PIK3CG0.60714066
121ALK0.60408572
122PINK10.59696577
123PAK20.59586713
124CAMKK20.58674406
125MOS0.58513378
126MAP2K20.58196637
127PKN10.57920013
128AURKB0.57626233
129DDR20.55580373
130NLK0.54973366
131TSSK60.54952143
132TYRO30.54926713
133CLK10.54859425
134TLK10.54824079
135CSNK1A1L0.52776937
136MST1R0.52488106
137CDK11A0.51884180
138CDC42BPA0.51563534
139PRKDC0.51305041
140PKN20.50467891
141MELK0.49323336
142MAP3K100.49055017
143PDPK10.48929046
144WNK10.48790629
145RPS6KA50.48653155
146TGFBR10.47919465
147MUSK0.47714094
148WNK40.47398984
149RIPK10.47377249
150CDK30.47199743
151RET0.47075307
152MAPK100.46901946
153FGFR10.46764671
154ADRBK10.46193544
155CAMK40.45696631
156RPS6KA30.45397882
157RPS6KB20.45326847
158BRAF0.45242806
159GSK3B0.45129173
160AURKA0.44881362
161RPS6KA20.44207112
162PRKCZ0.43186921
163FLT30.42916156
164CCNB10.40705381
165ROCK20.40620598
166PRKAA20.40201382
167PRKACA0.39470712
168ERBB40.38410319
169PRKG10.38402675
170FYN0.38325676

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25237688
2Synaptic vesicle cycle_Homo sapiens_hsa047213.39886008
3GABAergic synapse_Homo sapiens_hsa047272.95954157
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84290432
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82748931
6Amphetamine addiction_Homo sapiens_hsa050312.68265195
7Morphine addiction_Homo sapiens_hsa050322.63290455
8Circadian entrainment_Homo sapiens_hsa047132.61959420
9Olfactory transduction_Homo sapiens_hsa047402.49140756
10Glutamatergic synapse_Homo sapiens_hsa047242.46974642
11ECM-receptor interaction_Homo sapiens_hsa045122.38777515
12Long-term potentiation_Homo sapiens_hsa047202.32195117
13Protein digestion and absorption_Homo sapiens_hsa049742.26891497
14Non-homologous end-joining_Homo sapiens_hsa034502.26848353
15Dopaminergic synapse_Homo sapiens_hsa047282.23527927
16Taste transduction_Homo sapiens_hsa047422.22366587
17Serotonergic synapse_Homo sapiens_hsa047262.20832012
18Salivary secretion_Homo sapiens_hsa049702.18181187
19Cocaine addiction_Homo sapiens_hsa050302.17437280
20DNA replication_Homo sapiens_hsa030302.06785960
21Insulin secretion_Homo sapiens_hsa049111.97890666
22Fatty acid biosynthesis_Homo sapiens_hsa000611.94040707
23Collecting duct acid secretion_Homo sapiens_hsa049661.89463789
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89285010
25RNA transport_Homo sapiens_hsa030131.89059674
26Basal cell carcinoma_Homo sapiens_hsa052171.85325505
27Cholinergic synapse_Homo sapiens_hsa047251.83749013
28Renin secretion_Homo sapiens_hsa049241.82542570
29Gastric acid secretion_Homo sapiens_hsa049711.78228753
30Cell cycle_Homo sapiens_hsa041101.77818362
31Long-term depression_Homo sapiens_hsa047301.76805392
32Calcium signaling pathway_Homo sapiens_hsa040201.75472124
33Hippo signaling pathway_Homo sapiens_hsa043901.74311794
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69752433
35Fanconi anemia pathway_Homo sapiens_hsa034601.64775655
36Mismatch repair_Homo sapiens_hsa034301.61997698
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59577430
38Adherens junction_Homo sapiens_hsa045201.54383814
39Oxytocin signaling pathway_Homo sapiens_hsa049211.49646851
40TGF-beta signaling pathway_Homo sapiens_hsa043501.49539215
41Biosynthesis of amino acids_Homo sapiens_hsa012301.48925859
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45464934
43Nucleotide excision repair_Homo sapiens_hsa034201.44917776
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41068291
45GnRH signaling pathway_Homo sapiens_hsa049121.30128598
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29554067
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27081989
48Gap junction_Homo sapiens_hsa045401.26593433
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25652648
50Selenocompound metabolism_Homo sapiens_hsa004501.25143414
51cAMP signaling pathway_Homo sapiens_hsa040241.24835276
52Systemic lupus erythematosus_Homo sapiens_hsa053221.22965421
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21730111
54Cardiac muscle contraction_Homo sapiens_hsa042601.21105106
55Vibrio cholerae infection_Homo sapiens_hsa051101.20029097
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17597526
57Axon guidance_Homo sapiens_hsa043601.16160355
58Focal adhesion_Homo sapiens_hsa045101.15932967
59One carbon pool by folate_Homo sapiens_hsa006701.11595913
60Type II diabetes mellitus_Homo sapiens_hsa049301.08008605
61Oxidative phosphorylation_Homo sapiens_hsa001901.07118839
62Melanogenesis_Homo sapiens_hsa049161.05941126
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05917057
64Estrogen signaling pathway_Homo sapiens_hsa049151.04899016
65Lysine degradation_Homo sapiens_hsa003101.04109759
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.03677670
67mRNA surveillance pathway_Homo sapiens_hsa030151.02559447
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01754215
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01312316
70Small cell lung cancer_Homo sapiens_hsa052221.00931849
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00722504
72MicroRNAs in cancer_Homo sapiens_hsa052060.98443212
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98193873
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97141396
75Homologous recombination_Homo sapiens_hsa034400.96574903
76Phototransduction_Homo sapiens_hsa047440.96144397
77Arginine biosynthesis_Homo sapiens_hsa002200.95575842
78Thyroid cancer_Homo sapiens_hsa052160.94890837
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94691473
80Nitrogen metabolism_Homo sapiens_hsa009100.94108185
81Basal transcription factors_Homo sapiens_hsa030220.93473082
82Alzheimers disease_Homo sapiens_hsa050100.93105542
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92683394
84ErbB signaling pathway_Homo sapiens_hsa040120.90565728
85Type I diabetes mellitus_Homo sapiens_hsa049400.90283863
86Purine metabolism_Homo sapiens_hsa002300.90041921
87Tight junction_Homo sapiens_hsa045300.89919183
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88565153
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87541418
90Parkinsons disease_Homo sapiens_hsa050120.86870147
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84087407
92Folate biosynthesis_Homo sapiens_hsa007900.83945767
93Base excision repair_Homo sapiens_hsa034100.82317550
94Dilated cardiomyopathy_Homo sapiens_hsa054140.79748285
95Sulfur relay system_Homo sapiens_hsa041220.77473582
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76099537
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75809345
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.72877205
99N-Glycan biosynthesis_Homo sapiens_hsa005100.72665376
100Pancreatic secretion_Homo sapiens_hsa049720.72110921
101Dorso-ventral axis formation_Homo sapiens_hsa043200.71423031
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70795122
103Glioma_Homo sapiens_hsa052140.70553272
104Thyroid hormone synthesis_Homo sapiens_hsa049180.69932025
105Choline metabolism in cancer_Homo sapiens_hsa052310.68232226
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65685032
107MAPK signaling pathway_Homo sapiens_hsa040100.65424813
108Proteoglycans in cancer_Homo sapiens_hsa052050.63656168
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62896498
110Alcoholism_Homo sapiens_hsa050340.62551344
111Oocyte meiosis_Homo sapiens_hsa041140.62225215
112RNA degradation_Homo sapiens_hsa030180.61445460
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59444930
114Colorectal cancer_Homo sapiens_hsa052100.59345926
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.59061486
116Pathways in cancer_Homo sapiens_hsa052000.58587964
117Ovarian steroidogenesis_Homo sapiens_hsa049130.57945657
118Ras signaling pathway_Homo sapiens_hsa040140.56972967
119Wnt signaling pathway_Homo sapiens_hsa043100.56595485
120Pyruvate metabolism_Homo sapiens_hsa006200.56401929
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55526271
122Rheumatoid arthritis_Homo sapiens_hsa053230.51882775
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51246317
124Arginine and proline metabolism_Homo sapiens_hsa003300.49330342
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49230735
126Huntingtons disease_Homo sapiens_hsa050160.48834485
127Amoebiasis_Homo sapiens_hsa051460.48315512
128Carbon metabolism_Homo sapiens_hsa012000.48212590
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.48158776
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48089028
131Rap1 signaling pathway_Homo sapiens_hsa040150.47772363
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46145642
133Fatty acid metabolism_Homo sapiens_hsa012120.45988987
134African trypanosomiasis_Homo sapiens_hsa051430.45125192
135Spliceosome_Homo sapiens_hsa030400.44581821
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44009130
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43702089
138Viral carcinogenesis_Homo sapiens_hsa052030.42985595
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42694977
140Glucagon signaling pathway_Homo sapiens_hsa049220.41184139
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40458708
142Inositol phosphate metabolism_Homo sapiens_hsa005620.39709006
143Hedgehog signaling pathway_Homo sapiens_hsa043400.36910153
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.35193036
145Butanoate metabolism_Homo sapiens_hsa006500.33503547
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33310838
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32451680
148Circadian rhythm_Homo sapiens_hsa047100.31226390
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31070365
150Endocytosis_Homo sapiens_hsa041440.25770560
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24619719
152Prion diseases_Homo sapiens_hsa050200.24489033
153Bile secretion_Homo sapiens_hsa049760.24112899
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.23749471
155Melanoma_Homo sapiens_hsa052180.23266365
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22768413
157Ether lipid metabolism_Homo sapiens_hsa005650.22541478
158Phagosome_Homo sapiens_hsa041450.22016176
159Neurotrophin signaling pathway_Homo sapiens_hsa047220.21633021
160Chemokine signaling pathway_Homo sapiens_hsa040620.21448606
161Renal cell carcinoma_Homo sapiens_hsa052110.16976162

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