COL27A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)7.98951509
2keratan sulfate catabolic process (GO:0042340)7.73784669
3chondrocyte development (GO:0002063)7.32372004
4cell aggregation (GO:0098743)6.66486760
5cartilage condensation (GO:0001502)6.66486760
6negative regulation of fibrinolysis (GO:0051918)6.56021647
7regulation of fibrinolysis (GO:0051917)6.03726884
8collagen fibril organization (GO:0030199)5.86307609
9very-low-density lipoprotein particle assembly (GO:0034379)5.58346943
10intestinal cholesterol absorption (GO:0030299)5.47094796
11plasma lipoprotein particle assembly (GO:0034377)5.45153735
12positive regulation of extracellular matrix organization (GO:1903055)5.39298090
13regulation of protein activation cascade (GO:2000257)5.29203438
14regulation of complement activation (GO:0030449)5.18845762
15regulation of apoptotic cell clearance (GO:2000425)5.08977927
16limb bud formation (GO:0060174)4.89238936
17protein-lipid complex remodeling (GO:0034368)4.81884681
18macromolecular complex remodeling (GO:0034367)4.81884681
19plasma lipoprotein particle remodeling (GO:0034369)4.81884681
20protein-lipid complex assembly (GO:0065005)4.78636059
21low-density lipoprotein particle remodeling (GO:0034374)4.77816678
22high-density lipoprotein particle remodeling (GO:0034375)4.70143154
23regulation of extracellular matrix disassembly (GO:0010715)4.65905486
24cellular glucuronidation (GO:0052695)4.64557151
25cholesterol efflux (GO:0033344)4.58923691
26notochord development (GO:0030903)4.56929250
27regulation of cholesterol esterification (GO:0010872)4.50484117
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.43512625
29reverse cholesterol transport (GO:0043691)4.42857458
30plasma lipoprotein particle organization (GO:0071827)4.36148486
31blood coagulation, intrinsic pathway (GO:0007597)4.33526349
32chondrocyte differentiation (GO:0002062)4.29162161
33collagen catabolic process (GO:0030574)4.22974519
34cartilage development (GO:0051216)4.18373368
35negative regulation of gluconeogenesis (GO:0045721)4.13038185
36plasma lipoprotein particle clearance (GO:0034381)4.09639138
37collagen metabolic process (GO:0032963)4.09187091
38glucuronate metabolic process (GO:0019585)4.06975061
39uronic acid metabolic process (GO:0006063)4.06975061
40protein-lipid complex subunit organization (GO:0071825)4.06472496
41negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.97932280
42positive regulation of chondrocyte differentiation (GO:0032332)3.95089154
43nephron epithelium morphogenesis (GO:0072088)3.94342898
44nephron tubule morphogenesis (GO:0072078)3.94342898
45regulation of plasminogen activation (GO:0010755)3.91243369
46multicellular organismal catabolic process (GO:0044243)3.87932098
47chondroitin sulfate biosynthetic process (GO:0030206)3.86911475
48proteoglycan metabolic process (GO:0006029)3.86470166
49multicellular organismal macromolecule metabolic process (GO:0044259)3.83303807
50regulation of extracellular matrix organization (GO:1903053)3.79921902
51negative regulation of sterol transport (GO:0032372)3.74580589
52negative regulation of cholesterol transport (GO:0032375)3.74580589
53embryonic skeletal joint morphogenesis (GO:0060272)3.70932216
54multicellular organismal metabolic process (GO:0044236)3.65944868
55negative regulation of protein activation cascade (GO:2000258)3.65495524
56positive regulation of cartilage development (GO:0061036)3.60378316
57intestinal absorption (GO:0050892)3.57141098
58replacement ossification (GO:0036075)3.55044645
59endochondral ossification (GO:0001958)3.55044645
60iron ion import (GO:0097286)3.51691750
61complement activation, alternative pathway (GO:0006957)3.50362823
62sulfur compound catabolic process (GO:0044273)3.50086764
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.45713551
64L-phenylalanine catabolic process (GO:0006559)3.45713551
65regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.41920460
66regulation of bile acid biosynthetic process (GO:0070857)3.41808075
67endothelial cell morphogenesis (GO:0001886)3.40516700
68phospholipid efflux (GO:0033700)3.38004429
69lipoprotein metabolic process (GO:0042157)3.35675222
70skeletal system development (GO:0001501)3.31731593
71extracellular matrix disassembly (GO:0022617)3.29668205
72aromatic amino acid family catabolic process (GO:0009074)3.27961358
73fibrinolysis (GO:0042730)3.27066571
74negative regulation of lipase activity (GO:0060192)3.25642200
75tryptophan catabolic process (GO:0006569)3.25410697
76indole-containing compound catabolic process (GO:0042436)3.25410697
77indolalkylamine catabolic process (GO:0046218)3.25410697
78protein carboxylation (GO:0018214)3.21270618
79peptidyl-glutamic acid carboxylation (GO:0017187)3.21270618
80diacylglycerol metabolic process (GO:0046339)3.19578167
81triglyceride homeostasis (GO:0070328)3.17902797
82acylglycerol homeostasis (GO:0055090)3.17902797
83endocardial cushion morphogenesis (GO:0003203)3.15494438
84positive regulation of fatty acid beta-oxidation (GO:0032000)3.15105919
85cell proliferation involved in metanephros development (GO:0072203)3.14606062
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.13421952
87L-phenylalanine metabolic process (GO:0006558)3.13421952
88regulation of chondrocyte differentiation (GO:0032330)3.12654915
89neurotransmitter-gated ion channel clustering (GO:0072578)3.12573712
90regulation of cholesterol biosynthetic process (GO:0045540)3.10780953
91tryptophan metabolic process (GO:0006568)3.10233012
92sterol transport (GO:0015918)3.08554380
93cholesterol transport (GO:0030301)3.08554380
94basement membrane organization (GO:0071711)3.07096809
95regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.06548494
96bone trabecula formation (GO:0060346)3.03569240
97regulation of non-canonical Wnt signaling pathway (GO:2000050)3.03422256
98negative regulation of chondrocyte differentiation (GO:0032331)3.02911578
99negative regulation of blood coagulation (GO:0030195)3.01412715
100negative regulation of hemostasis (GO:1900047)3.01412715
101protein activation cascade (GO:0072376)2.99987399
102glutamate metabolic process (GO:0006536)2.98711973
103positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.97116327
104connective tissue development (GO:0061448)2.97007069
105negative regulation of complement activation (GO:0045916)2.96978410
106cholesterol homeostasis (GO:0042632)2.95174680
107regulation of cartilage development (GO:0061035)2.94292415
108renal tubule morphogenesis (GO:0061333)2.93633394
109endodermal cell differentiation (GO:0035987)2.92599905
110keratan sulfate biosynthetic process (GO:0018146)2.92173622
111sterol homeostasis (GO:0055092)2.90886032
112positive regulation of steroid metabolic process (GO:0045940)2.90008579
113protein retention in ER lumen (GO:0006621)2.88721503
114low-density lipoprotein particle clearance (GO:0034383)2.87771088
115complement activation, classical pathway (GO:0006958)2.86921770
116negative regulation of fatty acid transport (GO:2000192)2.86140357
117positive regulation of lipoprotein lipase activity (GO:0051006)2.84431530
118positive regulation of triglyceride lipase activity (GO:0061365)2.84431530
119negative regulation of sodium ion transport (GO:0010766)2.83431337
120positive regulation of hormone biosynthetic process (GO:0046886)2.83334203
121positive regulation of hemostasis (GO:1900048)2.82649680
122positive regulation of blood coagulation (GO:0030194)2.82649680
123proline metabolic process (GO:0006560)2.81628682
124negative regulation of cartilage development (GO:0061037)2.81425022
125embryonic viscerocranium morphogenesis (GO:0048703)2.80620229
126keratan sulfate metabolic process (GO:0042339)2.80096961
127negative regulation of coagulation (GO:0050819)2.79313569
128mesenchyme morphogenesis (GO:0072132)2.79173522
129acute-phase response (GO:0006953)2.75119977
130glycosaminoglycan catabolic process (GO:0006027)2.73424273
131positive regulation of hormone metabolic process (GO:0032352)2.73402690
132kynurenine metabolic process (GO:0070189)2.72005175
133negative regulation of wound healing (GO:0061045)2.71948244
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70949643
135glomerular basement membrane development (GO:0032836)2.70665393
136positive regulation of fatty acid biosynthetic process (GO:0045723)2.70526381
137positive regulation of fatty acid oxidation (GO:0046321)2.66771332
138COPII vesicle coating (GO:0048208)2.66146747
139renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.66092626
140endocardial cushion development (GO:0003197)2.65766072
141proteoglycan biosynthetic process (GO:0030166)2.64915205
142negative regulation of digestive system process (GO:0060457)2.64169131
143positive regulation of synapse maturation (GO:0090129)2.63386955
144nucleotide-sugar biosynthetic process (GO:0009226)2.63134029
145glycoprotein metabolic process (GO:0009100)2.62916176
146sphingomyelin metabolic process (GO:0006684)2.62675436
147cell-cell junction maintenance (GO:0045217)2.61805994
148regulation of cholesterol metabolic process (GO:0090181)2.61523042
149fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.60307503
150chondrocyte proliferation (GO:0035988)2.59966231
151insulin-like growth factor receptor signaling pathway (GO:0048009)2.59291088
152cellular response to BMP stimulus (GO:0071773)2.58995804
153response to BMP (GO:0071772)2.58995804
154glycosaminoglycan biosynthetic process (GO:0006024)2.58766627
155chondroitin sulfate metabolic process (GO:0030204)2.58476105
156peptidyl-proline hydroxylation (GO:0019511)2.58391243
157regulation of humoral immune response (GO:0002920)2.58291237
158ethanol oxidation (GO:0006069)2.57529109
159aminoglycan catabolic process (GO:0006026)2.56663525
160embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56453577
161lipid homeostasis (GO:0055088)2.55979938
162aminoglycan biosynthetic process (GO:0006023)2.55267693
163G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.54332145
164pathway-restricted SMAD protein phosphorylation (GO:0060389)2.54272778
165positive regulation of coagulation (GO:0050820)2.52569051
166glyoxylate metabolic process (GO:0046487)2.52425019
167bile acid biosynthetic process (GO:0006699)2.51987149
168peptidyl-glutamic acid modification (GO:0018200)2.49433389
169hypotonic response (GO:0006971)2.49294452
170* extracellular matrix organization (GO:0030198)2.48483991
171regulation of cholesterol homeostasis (GO:2000188)2.48185737
172* extracellular structure organization (GO:0043062)2.47401430
173negative regulation of lipid transport (GO:0032369)2.47395040
174homocysteine metabolic process (GO:0050667)2.44092138
175lung epithelium development (GO:0060428)2.43708107
176cell proliferation involved in kidney development (GO:0072111)2.43697314
177protein heterotrimerization (GO:0070208)2.42142523
178chondroitin sulfate catabolic process (GO:0030207)2.41132009
179positive regulation of fat cell differentiation (GO:0045600)2.40292378
180alpha-linolenic acid metabolic process (GO:0036109)2.39077063
181ossification (GO:0001503)2.38834201
182negative regulation of cellular carbohydrate metabolic process (GO:0010677)2.38007926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.75856592
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.07289405
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.35083911
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.33523857
5GATA1_22025678_ChIP-Seq_K562_Human3.12773585
6* LXR_22158963_ChIP-Seq_LIVER_Mouse2.96790597
7AR_21572438_ChIP-Seq_LNCaP_Human2.88793959
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.61177775
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.52284537
10* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.44016010
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34671116
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18666337
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14539110
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.11524174
15* HNF4A_19822575_ChIP-Seq_HepG2_Human2.09308275
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05641903
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.03860062
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.96787847
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86498622
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85836713
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83936849
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76585490
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.75716313
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.75455433
25* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70086379
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69851135
27ZNF263_19887448_ChIP-Seq_K562_Human1.64979194
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64300313
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64158029
30CJUN_26792858_Chip-Seq_BT549_Human1.62351655
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60551264
32VDR_24787735_ChIP-Seq_THP-1_Human1.59430753
33DROSHA_22980978_ChIP-Seq_HELA_Human1.57948931
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57804533
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52614025
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.49837042
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.48996551
38CLOCK_20551151_ChIP-Seq_293T_Human1.47645619
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45074486
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.44592147
41* EED_16625203_ChIP-ChIP_MESCs_Mouse1.42264072
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38853642
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38370561
44CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38004740
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36141093
46* LXR_22292898_ChIP-Seq_THP-1_Human1.35245300
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34815060
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33310682
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.33092812
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27264967
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27264967
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27017709
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25540667
54KDM2B_26808549_Chip-Seq_K562_Human1.25094743
55TP53_18474530_ChIP-ChIP_U2OS_Human1.24187027
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21733817
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20785473
58TP53_22127205_ChIP-Seq_IMR90_Human1.20259882
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19911139
60RXR_22108803_ChIP-Seq_LS180_Human1.17342978
61GATA4_25053715_ChIP-Seq_YYC3_Human1.16571461
62* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16277492
63* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15647646
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15325150
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15325150
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14885406
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14601569
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14413680
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.10476813
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09742602
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.07744366
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.07744366
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.07280867
74RACK7_27058665_Chip-Seq_MCF-7_Human1.07089155
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06536078
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05573884
77SOX2_20726797_ChIP-Seq_SW620_Human1.05076136
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04995181
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.04867617
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04729732
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04570086
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04561771
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.04464507
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.04457499
85* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04414443
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04396303
87CTCF_27219007_Chip-Seq_Bcells_Human1.04185323
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.02732054
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02277862
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02212133
91* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01602609
92BRD4_25478319_ChIP-Seq_HGPS_Human1.01003057
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00971549
94* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00438833
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.00401440
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00358034
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00280473
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.00162561
99* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00138433
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00068142
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99380302
102* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99074404
103* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99074404
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98250930
105PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97463758
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.96939252
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96756081
108* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96655371
109RUNX1_27514584_Chip-Seq_MCF-7_Human0.96267323
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96108487
111EZH2_27294783_Chip-Seq_ESCs_Mouse0.96061010
112SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95809827
113POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95516558
114* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95253100
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94994599
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.94992327
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94836782
118* EZH2_27304074_Chip-Seq_ESCs_Mouse0.93937447
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93661725
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93352723
121* RING1B_27294783_Chip-Seq_ESCs_Mouse0.93162192
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93009333
123TP53_16413492_ChIP-PET_HCT116_Human0.92710035
124SMC4_20622854_ChIP-Seq_HELA_Human0.92703046
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.91643132
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91039070
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90840437
128* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.90704697
129* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90681592
130GATA6_25053715_ChIP-Seq_YYC3_Human0.90488769
131* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89478253
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89170589
133CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88715583
134* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88453766
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88038939
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.86550426
137IRF8_22096565_ChIP-ChIP_GC-B_Human0.86521007
138OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86437550
139* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86138902
140* TP53_23651856_ChIP-Seq_MEFs_Mouse0.86101253
141AHR_22903824_ChIP-Seq_MCF-7_Human0.85837566
142RUNX_20019798_ChIP-Seq_JUKART_Human0.85822559
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85777685
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85626507
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84695770
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.84412437
147* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83653681
148JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83168602
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81644054
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81368708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004134_abnormal_chest_morphology4.58958022
2MP0005503_abnormal_tendon_morphology4.25872307
3MP0002933_joint_inflammation4.11916873
4MP0002282_abnormal_trachea_morphology4.10494449
5MP0002139_abnormal_hepatobiliary_system3.46266085
6MP0000163_abnormal_cartilage_morphology3.24779239
7MP0009250_abnormal_appendicular_skeleto3.08603102
8MP0002115_abnormal_skeleton_extremities2.82716518
9MP0005360_urolithiasis2.81692986
10MP0008438_abnormal_cutaneous_collagen2.79988587
11MP0001666_abnormal_nutrient_absorption2.55619774
12MP0003252_abnormal_bile_duct2.50134111
13MP0001270_distended_abdomen2.49709098
14MP0005085_abnormal_gallbladder_physiolo2.43453063
15MP0009780_abnormal_chondrocyte_physiolo2.40622700
16MP0002896_abnormal_bone_mineralization2.33129145
17MP0009384_cardiac_valve_regurgitation2.28766188
18MP0005508_abnormal_skeleton_morphology2.19167279
19MP0002113_abnormal_skeleton_development2.18711421
20MP0000762_abnormal_tongue_morphology2.16940061
21MP0005365_abnormal_bile_salt2.08954166
22MP0000566_synostosis2.08364882
23MP0004272_abnormal_basement_membrane2.03751242
24MP0003705_abnormal_hypodermis_morpholog1.94725553
25MP0005390_skeleton_phenotype1.92217830
26MP0001299_abnormal_eye_distance/1.90637935
27MP0005275_abnormal_skin_tensile1.88132497
28MP0001533_abnormal_skeleton_physiology1.87283472
29MP0003195_calcinosis1.86814511
30MP0002109_abnormal_limb_morphology1.84487487
31MP0003646_muscle_fatigue1.81171575
32MP0002138_abnormal_hepatobiliary_system1.81099222
33MP0005409_darkened_coat_color1.79975792
34MP0002249_abnormal_larynx_morphology1.71588668
35MP0005670_abnormal_white_adipose1.63187685
36MP0002089_abnormal_postnatal_growth/wei1.62354259
37MP0003172_abnormal_lysosome_physiology1.61372165
38MP0006054_spinal_hemorrhage1.58260694
39MP0003279_aneurysm1.56775495
40MP0005377_hearing/vestibular/ear_phenot1.56601499
41MP0003878_abnormal_ear_physiology1.56601499
42MP0002938_white_spotting1.55167602
43MP0000003_abnormal_adipose_tissue1.52234474
44MP0002108_abnormal_muscle_morphology1.49561895
45MP0003795_abnormal_bone_structure1.49225906
46MP0000013_abnormal_adipose_tissue1.48839845
47MP0001915_intracranial_hemorrhage1.45418226
48MP0003122_maternal_imprinting1.43681771
49MP0002116_abnormal_craniofacial_bone1.40019646
50MP0005408_hypopigmentation1.38718472
51MP0003755_abnormal_palate_morphology1.34603247
52MP0009053_abnormal_anal_canal1.33570406
53MP0003121_genomic_imprinting1.33285204
54MP0002998_abnormal_bone_remodeling1.28444023
55MP0000432_abnormal_head_morphology1.27793353
56MP0003115_abnormal_respiratory_system1.26197548
57MP0003385_abnormal_body_wall1.19804502
58MP0000639_abnormal_adrenal_gland1.19160220
59MP0003283_abnormal_digestive_organ1.18466240
60MP0010329_abnormal_lipoprotein_level1.11614774
61MP0001542_abnormal_bone_strength1.11007172
62MP0000049_abnormal_middle_ear1.10992454
63MP0009840_abnormal_foam_cell1.09722930
64MP0002697_abnormal_eye_size1.08304295
65MP0010030_abnormal_orbit_morphology1.07625095
66MP0003136_yellow_coat_color1.07270221
67MP0002932_abnormal_joint_morphology1.06454586
68MP0003123_paternal_imprinting1.05894852
69MP0005666_abnormal_adipose_tissue1.05698540
70MP0005023_abnormal_wound_healing1.03275609
71MP0003937_abnormal_limbs/digits/tail_de1.02147911
72MP0002111_abnormal_tail_morphology1.01524266
73MP0003935_abnormal_craniofacial_develop1.00230984
74MP0003436_decreased_susceptibility_to0.98580051
75MP0002876_abnormal_thyroid_physiology0.98482450
76MP0000534_abnormal_ureter_morphology0.97525971
77MP0002254_reproductive_system_inflammat0.96626125
78MP0005332_abnormal_amino_acid0.96266062
79MP0005058_abnormal_lysosome_morphology0.95651267
80MP0004133_heterotaxia0.95338731
81MP0003191_abnormal_cellular_cholesterol0.95126848
82MP0000462_abnormal_digestive_system0.94947964
83MP0002060_abnormal_skin_morphology0.94707438
84MP0003868_abnormal_feces_composition0.94235019
85MP0003879_abnormal_hair_cell0.93475528
86MP0003566_abnormal_cell_adhesion0.93405143
87MP0003890_abnormal_embryonic-extraembry0.93390191
88MP0002233_abnormal_nose_morphology0.92718369
89MP0001958_emphysema0.90806287
90MP0004185_abnormal_adipocyte_glucose0.90678242
91MP0003806_abnormal_nucleotide_metabolis0.89597278
92MP0008004_abnormal_stomach_pH0.87489334
93MP0008875_abnormal_xenobiotic_pharmacok0.87222171
94MP0003045_fibrosis0.87095632
95MP0003942_abnormal_urinary_system0.86508222
96MP0006292_abnormal_olfactory_placode0.86368402
97MP0003119_abnormal_digestive_system0.86302966
98MP0003787_abnormal_imprinting0.85370004
99MP0002928_abnormal_bile_duct0.83156489
100MP0003091_abnormal_cell_migration0.82461645
101MP0000609_abnormal_liver_physiology0.78790647
102MP0001243_abnormal_dermal_layer0.77726888
103MP0002168_other_aberrant_phenotype0.77293319
104MP0005076_abnormal_cell_differentiation0.77195440
105MP0001661_extended_life_span0.76379845
106MP0000767_abnormal_smooth_muscle0.74952130
107MP0004197_abnormal_fetal_growth/weight/0.74771503
108MP0002114_abnormal_axial_skeleton0.74735012
109MP0002118_abnormal_lipid_homeostasis0.74711735
110MP0005220_abnormal_exocrine_pancreas0.74460428
111MP0003950_abnormal_plasma_membrane0.73385954
112MP0005248_abnormal_Harderian_gland0.73069668
113MP0005257_abnormal_intraocular_pressure0.72764871
114MP0005167_abnormal_blood-brain_barrier0.71983467
115MP0000428_abnormal_craniofacial_morphol0.71933644
116MP0009697_abnormal_copulation0.71725036
117MP0001849_ear_inflammation0.71684583
118MP0002163_abnormal_gland_morphology0.71553771
119MP0002092_abnormal_eye_morphology0.71389328
120MP0004043_abnormal_pH_regulation0.71200838
121MP0003567_abnormal_fetal_cardiomyocyte0.70795819
122MP0005381_digestive/alimentary_phenotyp0.69451140
123MP0000678_abnormal_parathyroid_gland0.68636537
124MP0004019_abnormal_vitamin_homeostasis0.67881834
125MP0003632_abnormal_nervous_system0.67720917
126MP0003656_abnormal_erythrocyte_physiolo0.67384506
127MP0002909_abnormal_adrenal_gland0.67319217
128MP0001756_abnormal_urination0.65621357
129MP0004858_abnormal_nervous_system0.63866004
130MP0005375_adipose_tissue_phenotype0.63134251
131MP0004264_abnormal_extraembryonic_tissu0.62865947
132MP0003941_abnormal_skin_development0.61119274
133MP0005448_abnormal_energy_balance0.60917283
134MP0002128_abnormal_blood_circulation0.60693539
135MP0000579_abnormal_nail_morphology0.60003715
136MP0001963_abnormal_hearing_physiology0.59973907
137MP0001286_abnormal_eye_development0.59448819
138MP0010368_abnormal_lymphatic_system0.59147233

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.81315410
2Deep venous thrombosis (HP:0002625)8.79584127
3Irregular epiphyses (HP:0010582)8.10654562
4Vitreoretinal degeneration (HP:0000655)7.10133061
5Hypoplastic ischia (HP:0003175)6.79983195
6Small epiphyses (HP:0010585)6.39529105
7Abnormality of the ischium (HP:0003174)6.06511765
8Prolonged partial thromboplastin time (HP:0003645)6.00781444
9Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.76468123
10Cupped ribs (HP:0000887)5.39111023
11Abnormal tarsal ossification (HP:0008369)5.32564970
12Flat capital femoral epiphysis (HP:0003370)5.04794566
13Delayed epiphyseal ossification (HP:0002663)4.95119006
14Flat acetabular roof (HP:0003180)4.87358582
15Joint hemorrhage (HP:0005261)4.70594773
16Genu varum (HP:0002970)4.49588734
17Complement deficiency (HP:0004431)4.49387751
18Hypobetalipoproteinemia (HP:0003563)4.35856976
19Neonatal short-limb short stature (HP:0008921)4.34816279
20Osteoarthritis (HP:0002758)4.00985610
21Mild short stature (HP:0003502)3.97279887
22Abnormal foot bone ossification (HP:0010675)3.94816846
23Abnormality of femoral epiphyses (HP:0006499)3.90254366
24Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.90254366
25Flattened epiphyses (HP:0003071)3.90138192
26Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.79210597
27Absent epiphyses (HP:0010577)3.79210597
28Arthropathy (HP:0003040)3.74265625
29Abnormality of the common coagulation pathway (HP:0010990)3.64335026
30Metaphyseal cupping (HP:0003021)3.58217658
31Abnormality of the vertebral endplates (HP:0005106)3.54737344
32Xanthomatosis (HP:0000991)3.54340840
33Abnormality of the epiphysis of the femoral head (HP:0010574)3.48449626
34Glomerulonephritis (HP:0000099)3.46248693
35Hypercholesterolemia (HP:0003124)3.41136405
36Protuberant abdomen (HP:0001538)3.40725744
37Abnormality of the pubic bones (HP:0003172)3.34055466
38Abnormality of complement system (HP:0005339)3.31079257
39Short femoral neck (HP:0100864)3.29171698
40Abnormality of carpal bone ossification (HP:0006257)3.25156134
41Metaphyseal irregularity (HP:0003025)3.24639796
42Abnormality of the femoral head (HP:0003368)3.21178263
43Abnormality of aromatic amino acid family metabolism (HP:0004338)3.14023644
44Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.07820381
45Enlarged epiphyses (HP:0010580)3.05625823
46Abnormal vertebral ossification (HP:0100569)3.04425438
47Metaphyseal dysplasia (HP:0100255)3.03135093
48Platyspondyly (HP:0000926)3.01632133
49Hemorrhage of the eye (HP:0011885)3.00956089
50Hypolipoproteinemia (HP:0010981)3.00669251
51Bronchomalacia (HP:0002780)3.00194732
52Barrel-shaped chest (HP:0001552)2.99834394
53Menorrhagia (HP:0000132)2.97621222
54Irregular vertebral endplates (HP:0003301)2.95985396
55Abnormality of the nasal septum (HP:0000419)2.93009400
56Asymmetry of the thorax (HP:0001555)2.90892871
57Coxa vara (HP:0002812)2.85082966
58Broad palm (HP:0001169)2.85043816
59Vertebral clefting (HP:0008428)2.84043120
60Abnormal hand bone ossification (HP:0010660)2.83346288
61Exostoses (HP:0100777)2.80558001
62Alacrima (HP:0000522)2.77881003
63Limited hip movement (HP:0008800)2.77584308
64Spontaneous abortion (HP:0005268)2.75786262
65Cervical subluxation (HP:0003308)2.71225993
66Limited elbow extension (HP:0001377)2.70003263
67Abnormal ossification of hand bones (HP:0005921)2.68908153
68Ovoid vertebral bodies (HP:0003300)2.66863431
69Premature rupture of membranes (HP:0001788)2.65478872
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.61742634
71Mesomelia (HP:0003027)2.59222556
72Abnormality of the vitreous humor (HP:0004327)2.50132881
73Lumbar hyperlordosis (HP:0002938)2.49253878
74Thoracolumbar scoliosis (HP:0002944)2.48642416
75Vascular calcification (HP:0004934)2.48062864
76Abnormality of incisor morphology (HP:0011063)2.46785538
77Systemic lupus erythematosus (HP:0002725)2.46680575
78Epidermoid cyst (HP:0200040)2.45809609
79Hip contracture (HP:0003273)2.44896679
80Mitral stenosis (HP:0001718)2.44675706
81Aplasia/hypoplasia of the femur (HP:0005613)2.44533174
82Waddling gait (HP:0002515)2.42268666
83Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.40900427
84Peritonitis (HP:0002586)2.39213063
85Cerebral aneurysm (HP:0004944)2.38103313
86Abnormality of the proximal phalanges of the hand (HP:0009834)2.36155044
87Broad alveolar ridges (HP:0000187)2.33574828
88Absent frontal sinuses (HP:0002688)2.32448778
89Fibular hypoplasia (HP:0003038)2.30714372
90Beaking of vertebral bodies (HP:0004568)2.29468769
91Thin ribs (HP:0000883)2.28620605
92Cardiovascular calcification (HP:0011915)2.25854219
93Hypoalphalipoproteinemia (HP:0003233)2.25262560
94Micromelia (HP:0002983)2.21382609
95Hypoplasia of the odontoid process (HP:0003311)2.20318131
96Shallow orbits (HP:0000586)2.18541114
97Abnormality of monocarboxylic acid metabolism (HP:0010996)2.17842885
98Bell-shaped thorax (HP:0001591)2.16698403
99Rhizomelia (HP:0008905)2.14554373
100Long clavicles (HP:0000890)2.13133297
101Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12716048
102Nephritis (HP:0000123)2.11727954
103Biconcave vertebral bodies (HP:0004586)2.10958478
104Spinal cord compression (HP:0002176)2.10724344
105Stillbirth (HP:0003826)2.09218234
106Acanthocytosis (HP:0001927)2.08994514
107Facial shape deformation (HP:0011334)2.07737919
108Potter facies (HP:0002009)2.07737919
109Broad phalanx (HP:0006009)2.07284498
110Decreased lacrimation (HP:0000633)2.06836143
111Aortic dissection (HP:0002647)2.04896613
112Abnormality of the lumbar spine (HP:0100712)2.04696511
113Mixed hearing impairment (HP:0000410)2.04305269
114Abnormality of the acetabulum (HP:0003170)2.02835683
115Vaginal fistula (HP:0004320)2.02508999
116Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01278697
117Coronal craniosynostosis (HP:0004440)2.00931623
118Skin nodule (HP:0200036)2.00876793
119Ulnar bowing (HP:0003031)2.00014050
120Broad long bones (HP:0005622)1.99637958
121Broad thumb (HP:0011304)1.98891388
122Flared iliac wings (HP:0002869)1.98057117
123Hypoplastic ilia (HP:0000946)1.97835058
124Lymphangioma (HP:0100764)1.97692258
125Ectopia lentis (HP:0001083)1.97538389
126Wide anterior fontanel (HP:0000260)1.97433190
127Relative macrocephaly (HP:0004482)1.96428189
128Neonatal death (HP:0003811)1.96293122
129Disproportionate short-trunk short stature (HP:0003521)1.95144208
130Genu valgum (HP:0002857)1.93848495
131Abnormality of the wing of the ilium (HP:0011867)1.91862318
132Hypophosphatemic rickets (HP:0004912)1.89927038
133Short middle phalanx of finger (HP:0005819)1.89388751
134Abnormality of the middle phalanges of the toes (HP:0010183)1.88966873
135Abnormality of the lacrimal duct (HP:0011481)1.85580877
136Flared metaphyses (HP:0003015)1.84667168
137Enlarged kidneys (HP:0000105)1.83366154
138Abnormality of the odontoid process (HP:0003310)1.83116191
139Abnormal delivery (HP:0001787)1.82296454
140Arterial tortuosity (HP:0005116)1.82100246
141Hyperlipoproteinemia (HP:0010980)1.82020129
142Aplasia involving bones of the upper limbs (HP:0009823)1.81644412
143Aplasia of the phalanges of the hand (HP:0009802)1.81644412
144Aplasia involving bones of the extremities (HP:0009825)1.81644412
145Carpal bone hypoplasia (HP:0001498)1.81037242
146Vertebral hypoplasia (HP:0008417)1.80353356
147Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80353356
148Glossoptosis (HP:0000162)1.80139151
149Trigonocephaly (HP:0000243)1.80003858
150Hepatoblastoma (HP:0002884)1.79446894
151Atrophic scars (HP:0001075)1.79176594
152Protrusio acetabuli (HP:0003179)1.78961429
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78650555
154Abnormality of the 2nd finger (HP:0004100)1.78533198
155Severe Myopia (HP:0011003)1.77677348
156Sprengel anomaly (HP:0000912)1.77614058
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76525724
158Renal duplication (HP:0000075)1.76407987
159Hydroxyprolinuria (HP:0003080)1.75389796
160Abnormality of proline metabolism (HP:0010907)1.75389796
161Abnormality of the intervertebral disk (HP:0005108)1.74728220
162Intestinal fistula (HP:0100819)1.73389336
163Abnormality of dentin (HP:0010299)1.72391173
164Anal stenosis (HP:0002025)1.71984646
165Advanced eruption of teeth (HP:0006288)1.71252503
166Abnormality of the intrinsic pathway (HP:0010989)1.70743664
167Abnormality of pain sensation (HP:0010832)1.70611196
168Impaired pain sensation (HP:0007328)1.70611196
169Bifid scrotum (HP:0000048)1.70233157
170Vascular tortuosity (HP:0004948)1.70013553
171Obstructive sleep apnea (HP:0002870)1.68651909
172Supernumerary ribs (HP:0005815)1.68205016
173Morphological abnormality of the middle ear (HP:0008609)1.68072490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.23587319
2SIK14.15393170
3MAP3K34.00630564
4TGFBR23.08041148
5STK38L2.92662541
6LATS12.42755436
7TYRO32.37941310
8MAPK152.29573075
9STK241.99761691
10AKT31.91325630
11CSF1R1.86848201
12CAMK1D1.82636793
13ERN11.71243411
14CDC42BPA1.69461986
15PRKG21.68664850
16FGFR41.64378934
17EEF2K1.59801448
18STK31.58440707
19CAMK1G1.55816102
20EPHB11.46937143
21NUAK11.42681850
22LATS21.40861017
23WNK41.40242702
24INSRR1.39987732
25NTRK31.37508336
26EPHA21.34135232
27TRIB31.33017292
28MAP3K101.29852696
29JAK11.27264953
30NTRK11.25362832
31MAPK71.23792783
32MAPKAPK31.16350849
33PTK61.14591324
34NME11.13327540
35FGFR21.11711650
36MAP3K71.09958727
37EPHB21.08045266
38EPHA31.07571796
39PIK3CA1.06549937
40MAPK121.06013631
41MAP3K141.05815049
42NEK21.03756119
43MAP2K61.02754035
44TRPM70.98715831
45RET0.98100246
46CHUK0.96579671
47PRKAA20.95359137
48NEK90.93729093
49NTRK20.89445912
50PNCK0.88554373
51GSK3A0.88312724
52MET0.84261987
53MARK20.84013868
54WNK10.83405866
55FGFR30.82547957
56EIF2AK20.81278141
57PKN20.80744130
58PIK3CG0.80691089
59MAP3K60.80046975
60BRD40.75752020
61BCKDK0.75392199
62EPHA40.75010720
63TYK20.73312517
64ROCK10.73072817
65SGK30.73003059
66IRAK30.72282799
67IKBKB0.69598487
68NLK0.68485266
69PDPK10.67627042
70ERBB30.66311918
71STK380.64928909
72MTOR0.60731399
73CDK30.60519215
74MST1R0.60199983
75ICK0.58000838
76CDK90.56556269
77TBK10.56035700
78IRAK10.55390986
79SMG10.54989845
80IGF1R0.54807464
81CSNK1A1L0.54540807
82MAP2K30.53792903
83PTK20.53437714
84GRK70.53201752
85HIPK20.52740325
86PAK20.52720624
87FGFR10.52580665
88SGK20.51872102
89MKNK20.51342720
90PRKCG0.51252864
91MAPK40.51184471
92PDGFRA0.51126120
93BMX0.50929879
94DYRK1A0.50519499
95CAMK40.50506625
96MAPK110.50102824
97PKN10.49451227
98CDK120.49376545
99NEK60.48095528
100PDK20.48046421
101CSNK1E0.47956063
102PAK40.46744455
103ERBB20.46283219
104PRKAA10.46126493
105ERBB40.44864461
106CDK60.44695137
107CSK0.43728119
108RIPK10.43012266
109MARK30.42499171
110CDK70.42145623
111MAPK100.39338229
112INSR0.38977773
113PRKD20.38961079
114PDGFRB0.38890556
115DYRK1B0.38679744
116RPS6KA20.38274765
117FER0.37939040
118PLK20.37708799
119LMTK20.37396130
120MAPK80.37135670
121SIK20.35542218
122FRK0.34577167
123SRC0.34450436
124RPS6KA30.32704209
125SGK10.32256860
126MELK0.31464786
127PRKCH0.31297715
128ABL10.31231659
129MAPKAPK50.31193376
130MAPK10.30778937
131FLT30.30778347
132STK390.30768318
133DAPK20.30157433
134PRKCZ0.29883784
135IRAK40.29758817
136PTK2B0.29613958
137MAP3K20.29286479
138SGK4940.28744952
139SGK2230.28744952
140PDK10.28702805
141GSK3B0.28044083
142MAPK30.27860178
143MYLK0.27698739
144CSNK1D0.27435238
145PRKD30.27331155
146RPS6KB10.25836998

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.86247719
2ECM-receptor interaction_Homo sapiens_hsa045123.74014899
3* Protein digestion and absorption_Homo sapiens_hsa049743.49712332
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.96991807
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.88791552
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31404558
7Sulfur metabolism_Homo sapiens_hsa009202.26514137
8Complement and coagulation cascades_Homo sapiens_hsa046102.22356496
9Nitrogen metabolism_Homo sapiens_hsa009102.05750890
10Lysine degradation_Homo sapiens_hsa003101.99476851
11Staphylococcus aureus infection_Homo sapiens_hsa051501.89825097
12Tryptophan metabolism_Homo sapiens_hsa003801.86409544
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.85638922
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72456145
15PPAR signaling pathway_Homo sapiens_hsa033201.70063853
16Fatty acid degradation_Homo sapiens_hsa000711.68493085
17Starch and sucrose metabolism_Homo sapiens_hsa005001.68330517
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67033794
19Selenocompound metabolism_Homo sapiens_hsa004501.66776219
20Fatty acid biosynthesis_Homo sapiens_hsa000611.63753695
21Arginine biosynthesis_Homo sapiens_hsa002201.44128145
22Focal adhesion_Homo sapiens_hsa045101.41897026
23Propanoate metabolism_Homo sapiens_hsa006401.41419992
24Vitamin B6 metabolism_Homo sapiens_hsa007501.41031531
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35897172
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35101445
27Other glycan degradation_Homo sapiens_hsa005111.33557527
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.31087704
29Butanoate metabolism_Homo sapiens_hsa006501.30465368
30Steroid biosynthesis_Homo sapiens_hsa001001.29273997
31Fatty acid metabolism_Homo sapiens_hsa012121.26514685
32Peroxisome_Homo sapiens_hsa041461.25603484
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22859634
34Thyroid hormone synthesis_Homo sapiens_hsa049181.17486095
35Retinol metabolism_Homo sapiens_hsa008301.14537202
36Basal cell carcinoma_Homo sapiens_hsa052171.13791944
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13019993
38Bile secretion_Homo sapiens_hsa049761.12365237
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.10374165
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08849879
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03589072
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03268248
43Chemical carcinogenesis_Homo sapiens_hsa052041.02318410
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02223583
45Glycerolipid metabolism_Homo sapiens_hsa005611.01494232
46Histidine metabolism_Homo sapiens_hsa003401.01100830
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97254066
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96373477
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94945803
50beta-Alanine metabolism_Homo sapiens_hsa004100.93472826
51Hedgehog signaling pathway_Homo sapiens_hsa043400.92642196
52TGF-beta signaling pathway_Homo sapiens_hsa043500.90745127
53Arginine and proline metabolism_Homo sapiens_hsa003300.90037832
54Insulin resistance_Homo sapiens_hsa049310.88744248
55Malaria_Homo sapiens_hsa051440.88244219
56Vitamin digestion and absorption_Homo sapiens_hsa049770.87149617
57ABC transporters_Homo sapiens_hsa020100.85648722
58Fructose and mannose metabolism_Homo sapiens_hsa000510.82104073
59Sphingolipid metabolism_Homo sapiens_hsa006000.81734141
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81297514
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.80929161
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79683082
63Folate biosynthesis_Homo sapiens_hsa007900.75519365
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74432493
65Proteoglycans in cancer_Homo sapiens_hsa052050.70881708
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69962962
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65389026
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65225870
69Biosynthesis of amino acids_Homo sapiens_hsa012300.61987786
70Phenylalanine metabolism_Homo sapiens_hsa003600.61857374
71Renin-angiotensin system_Homo sapiens_hsa046140.61578303
72N-Glycan biosynthesis_Homo sapiens_hsa005100.61399982
73Wnt signaling pathway_Homo sapiens_hsa043100.60756966
74Osteoclast differentiation_Homo sapiens_hsa043800.57941906
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56656750
76Axon guidance_Homo sapiens_hsa043600.56204960
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52756962
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51972683
79Ovarian steroidogenesis_Homo sapiens_hsa049130.51186637
80Prostate cancer_Homo sapiens_hsa052150.50445825
81Adherens junction_Homo sapiens_hsa045200.50283833
82Hippo signaling pathway_Homo sapiens_hsa043900.50109733
83Tyrosine metabolism_Homo sapiens_hsa003500.49434810
84Amoebiasis_Homo sapiens_hsa051460.49209802
85Mineral absorption_Homo sapiens_hsa049780.47941753
86Fatty acid elongation_Homo sapiens_hsa000620.47891940
87Circadian rhythm_Homo sapiens_hsa047100.47308282
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46713763
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46384149
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.45243043
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44155293
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43756651
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.42236923
94Galactose metabolism_Homo sapiens_hsa000520.41013005
95Prion diseases_Homo sapiens_hsa050200.40752541
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38861067
97Insulin signaling pathway_Homo sapiens_hsa049100.37394262
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.37088442
99Insulin secretion_Homo sapiens_hsa049110.37044082
100Small cell lung cancer_Homo sapiens_hsa052220.36251900
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36112157
102One carbon pool by folate_Homo sapiens_hsa006700.35621269
103Pyruvate metabolism_Homo sapiens_hsa006200.34289043
104Tight junction_Homo sapiens_hsa045300.34078606
105Notch signaling pathway_Homo sapiens_hsa043300.33770219
106Caffeine metabolism_Homo sapiens_hsa002320.33707394
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33031653
108Melanogenesis_Homo sapiens_hsa049160.32464809
109Glutamatergic synapse_Homo sapiens_hsa047240.32434587
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32431976
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32273366
112Fat digestion and absorption_Homo sapiens_hsa049750.32140297
113TNF signaling pathway_Homo sapiens_hsa046680.30869653
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.30698950
115B cell receptor signaling pathway_Homo sapiens_hsa046620.30343945
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30022073
117Type II diabetes mellitus_Homo sapiens_hsa049300.29963303
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28623095
119AMPK signaling pathway_Homo sapiens_hsa041520.25886574
120Toxoplasmosis_Homo sapiens_hsa051450.24999778
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24427118
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23437793
123Arachidonic acid metabolism_Homo sapiens_hsa005900.22941284
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21813780
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20901662
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.20499540
127Glucagon signaling pathway_Homo sapiens_hsa049220.19814395

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »