COL28A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell junction maintenance (GO:0045217)7.11078759
2neuronal action potential propagation (GO:0019227)6.64944968
3peripheral nervous system axon ensheathment (GO:0032292)6.60070887
4myelination in peripheral nervous system (GO:0022011)6.60070887
5cilium or flagellum-dependent cell motility (GO:0001539)6.31315147
6behavioral response to nicotine (GO:0035095)5.93311821
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.90588978
8cell junction maintenance (GO:0034331)5.55326075
9axonemal dynein complex assembly (GO:0070286)5.51541702
10cilium movement (GO:0003341)5.30584740
11collagen fibril organization (GO:0030199)4.97638522
12epithelial cilium movement (GO:0003351)4.96130425
13hemidesmosome assembly (GO:0031581)4.57234754
14fat-soluble vitamin catabolic process (GO:0042363)4.47719285
15vitamin catabolic process (GO:0009111)4.47719285
16neurofilament cytoskeleton organization (GO:0060052)4.47216197
17cell adhesion mediated by integrin (GO:0033627)4.44134395
18L-fucose catabolic process (GO:0042355)4.34850652
19fucose catabolic process (GO:0019317)4.34850652
20L-fucose metabolic process (GO:0042354)4.34850652
21protein heterotrimerization (GO:0070208)4.33508962
22plasma membrane repair (GO:0001778)4.15971929
23axon ensheathment (GO:0008366)4.13958517
24ensheathment of neurons (GO:0007272)4.13958517
25motile cilium assembly (GO:0044458)4.03677231
26primary amino compound metabolic process (GO:1901160)4.00954886
27serotonin metabolic process (GO:0042428)3.86313250
28axoneme assembly (GO:0035082)3.81115492
29cytoskeletal anchoring at plasma membrane (GO:0007016)3.77150217
30basement membrane organization (GO:0071711)3.74542016
31peptidyl-tyrosine autophosphorylation (GO:0038083)3.70338757
32regulation of pigment cell differentiation (GO:0050932)3.70210279
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.70119914
34sulfation (GO:0051923)3.68196172
35proline transport (GO:0015824)3.60801885
36collagen catabolic process (GO:0030574)3.57916650
37cilium organization (GO:0044782)3.56433259
38extracellular fibril organization (GO:0043206)3.55146030
39indole-containing compound catabolic process (GO:0042436)3.54741588
40indolalkylamine catabolic process (GO:0046218)3.54741588
41tryptophan catabolic process (GO:0006569)3.54741588
42male sex determination (GO:0030238)3.52499281
43collagen metabolic process (GO:0032963)3.50310706
44cilium assembly (GO:0042384)3.49341630
45kynurenine metabolic process (GO:0070189)3.48512629
46bone trabecula formation (GO:0060346)3.48457924
47cellular ketone body metabolic process (GO:0046950)3.46441298
48myelin assembly (GO:0032288)3.45528158
49cellular component maintenance (GO:0043954)3.45067364
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.41465534
51nonmotile primary cilium assembly (GO:0035058)3.40894143
52endodermal cell differentiation (GO:0035987)3.39665873
53indole-containing compound metabolic process (GO:0042430)3.36180545
54multicellular organismal macromolecule metabolic process (GO:0044259)3.34621132
55myelination (GO:0042552)3.32154719
56peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.31506533
57peripheral nervous system development (GO:0007422)3.29462132
58Leydig cell differentiation (GO:0033327)3.29380589
59indolalkylamine metabolic process (GO:0006586)3.26936266
60gamma-aminobutyric acid transport (GO:0015812)3.26357994
61multicellular organismal catabolic process (GO:0044243)3.25179575
62vitamin transmembrane transport (GO:0035461)3.21575759
63extracellular matrix disassembly (GO:0022617)3.21391695
64multicellular organismal metabolic process (GO:0044236)3.17239532
65cilium morphogenesis (GO:0060271)3.16983443
66neural tube formation (GO:0001841)3.16408977
67reflex (GO:0060004)3.16316956
68retinal cone cell development (GO:0046549)3.15388325
69detection of light stimulus involved in visual perception (GO:0050908)3.13577811
70detection of light stimulus involved in sensory perception (GO:0050962)3.13577811
71regulation of cilium movement (GO:0003352)3.10544488
72protein localization to cilium (GO:0061512)3.10468572
73detection of temperature stimulus (GO:0016048)3.09392244
74sequestering of extracellular ligand from receptor (GO:0035581)3.06196075
75ketone body metabolic process (GO:1902224)3.04149828
76neuronal action potential (GO:0019228)3.01163520
77behavioral response to ethanol (GO:0048149)3.00447305
78transmission of nerve impulse (GO:0019226)3.00165381
79tryptophan metabolic process (GO:0006568)2.98444765
80cranial nerve structural organization (GO:0021604)2.94607938
81skin development (GO:0043588)2.92593854
82ganglion development (GO:0061548)2.92349422
83nephron tubule morphogenesis (GO:0072078)2.91319066
84nephron epithelium morphogenesis (GO:0072088)2.91319066
85enteric nervous system development (GO:0048484)2.91140954
86positive regulation of Rho protein signal transduction (GO:0035025)2.88067222
87spinal cord motor neuron differentiation (GO:0021522)2.86110432
88positive regulation of developmental pigmentation (GO:0048087)2.86034854
89negative regulation of catenin import into nucleus (GO:0035414)2.85909608
90cell migration in hindbrain (GO:0021535)2.84541645
91pyrimidine-containing compound transmembrane transport (GO:0072531)2.83426044
92fibril organization (GO:0097435)2.82838926
93response to water (GO:0009415)2.82733193
94interkinetic nuclear migration (GO:0022027)2.81726323
95response to pheromone (GO:0019236)2.81404488
96myelin maintenance (GO:0043217)2.81363267
97multicellular organism reproduction (GO:0032504)2.81258603
98photoreceptor cell maintenance (GO:0045494)2.78262986
99urinary tract smooth muscle contraction (GO:0014848)2.78248386
100regulation of hippo signaling (GO:0035330)2.77894870
101startle response (GO:0001964)2.77863034
102cellular component assembly involved in morphogenesis (GO:0010927)2.77822090
103regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.76599207
104intraciliary transport (GO:0042073)2.75195899
105dermatan sulfate biosynthetic process (GO:0030208)2.73488607
106opioid receptor signaling pathway (GO:0038003)2.72012469
107positive regulation of fibroblast migration (GO:0010763)2.71375787
108cornea development in camera-type eye (GO:0061303)2.70115792
109phosphatidylinositol acyl-chain remodeling (GO:0036149)2.69612518
110behavioral response to pain (GO:0048266)2.68965907
111response to pain (GO:0048265)2.68807417
112left/right axis specification (GO:0070986)2.68128072
113detection of mechanical stimulus involved in sensory perception (GO:0050974)2.67748929
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65977813
115regulation of cardiac muscle hypertrophy (GO:0010611)2.65268298
116alanine transport (GO:0032328)2.65126835
117ubiquinone biosynthetic process (GO:0006744)2.62935325
118kidney morphogenesis (GO:0060993)2.61834966
119regulation of action potential (GO:0098900)2.59297555
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.58785059
121cellular biogenic amine catabolic process (GO:0042402)2.57117659
122amine catabolic process (GO:0009310)2.57117659
123benzene-containing compound metabolic process (GO:0042537)2.57068070
124piRNA metabolic process (GO:0034587)2.56615872
125neuron projection regeneration (GO:0031102)2.56592276
126protein import into peroxisome matrix (GO:0016558)2.56463621
127glial cell migration (GO:0008347)2.55487370
128cellular response to vitamin D (GO:0071305)2.55013257
129cell-matrix adhesion (GO:0007160)2.54911618
130negative regulation of dendrite morphogenesis (GO:0050774)2.54816453
131glomerular filtration (GO:0003094)2.54774640
132regulation of muscle hypertrophy (GO:0014743)2.54600375
133action potential (GO:0001508)2.54300203
134regulation of gene silencing by RNA (GO:0060966)2.54040204
135regulation of posttranscriptional gene silencing (GO:0060147)2.54040204
136regulation of gene silencing by miRNA (GO:0060964)2.54040204
137acrosome assembly (GO:0001675)2.53999482
138limb development (GO:0060173)2.53493308
139appendage development (GO:0048736)2.53493308
140positive regulation of cardiac muscle hypertrophy (GO:0010613)2.52829411
141positive regulation of muscle hypertrophy (GO:0014742)2.52829411
142regulation of neuron migration (GO:2001222)2.51547018
143cellular response to vitamin (GO:0071295)2.51035829
144synaptic transmission, cholinergic (GO:0007271)2.50818042
145negative regulation of JUN kinase activity (GO:0043508)2.50061136
146rRNA catabolic process (GO:0016075)2.49951001
147retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49447593
148anatomical structure arrangement (GO:0048532)2.48746390
149smoothened signaling pathway (GO:0007224)2.48604484
150peristalsis (GO:0030432)2.48396716
151photoreceptor cell development (GO:0042461)2.45464103
152positive regulation of nitric-oxide synthase activity (GO:0051000)2.45274761
153cellular response to exogenous dsRNA (GO:0071360)2.44381371
154inner ear receptor stereocilium organization (GO:0060122)2.44364719
155axon extension involved in axon guidance (GO:0048846)2.44304881
156neuron projection extension involved in neuron projection guidance (GO:1902284)2.44304881
157membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44127547
158cell-substrate junction assembly (GO:0007044)2.43250559
159* extracellular matrix organization (GO:0030198)2.42140152
160* extracellular structure organization (GO:0043062)2.41668680
161ubiquinone metabolic process (GO:0006743)2.41584830
162skin morphogenesis (GO:0043589)2.41477277
163regulation of mesoderm development (GO:2000380)2.40643676
164phosphatidylserine acyl-chain remodeling (GO:0036150)2.40045746
165negative regulation of mast cell activation (GO:0033004)2.39272593
166glycine transport (GO:0015816)2.38567285
167negative regulation of T cell differentiation in thymus (GO:0033085)2.38287470
168postsynaptic membrane organization (GO:0001941)2.38167738
169membrane depolarization during action potential (GO:0086010)2.37734305
170cell differentiation in spinal cord (GO:0021515)2.37724539
171determination of left/right symmetry (GO:0007368)2.37461730
172regulation of sodium ion transmembrane transporter activity (GO:2000649)2.37052715
173glutamate receptor signaling pathway (GO:0007215)2.36891102
174positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.36704771
175bundle of His cell to Purkinje myocyte communication (GO:0086069)2.36083169
176negative regulation of telomere maintenance (GO:0032205)2.34810200
177phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.34667761
178positive regulation of axon extension (GO:0045773)2.34562471
179response to lipoprotein particle (GO:0055094)2.34242825
180negative regulation of reactive oxygen species metabolic process (GO:2000378)2.34094436
181ovulation cycle (GO:0042698)2.33912757
182drug catabolic process (GO:0042737)2.33888485
183regulation of microtubule-based movement (GO:0060632)2.33129881
184dermatan sulfate metabolic process (GO:0030205)2.32983961
185chondrocyte proliferation (GO:0035988)2.32568683
186protein targeting to plasma membrane (GO:0072661)2.31619530
187renal filtration (GO:0097205)2.29634021
188growth hormone receptor signaling pathway (GO:0060396)2.29267959
189cellular response to amino acid stimulus (GO:0071230)2.28031765
190positive regulation of neurological system process (GO:0031646)2.26114517
191positive regulation of endothelial cell apoptotic process (GO:2000353)2.25251825
192craniofacial suture morphogenesis (GO:0097094)2.24774401
193response to parathyroid hormone (GO:0071107)2.24364417
194cell-substrate adhesion (GO:0031589)2.23271681
195muscle cell migration (GO:0014812)2.22294484
196semaphorin-plexin signaling pathway (GO:0071526)2.21708304
197detection of mechanical stimulus (GO:0050982)2.20861523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.67470404
2ZNF274_21170338_ChIP-Seq_K562_Hela3.54606715
3VDR_22108803_ChIP-Seq_LS180_Human3.34913529
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.28528865
5GBX2_23144817_ChIP-Seq_PC3_Human2.71436872
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.56629706
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23754639
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07332982
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.05360384
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02856677
11WT1_19549856_ChIP-ChIP_CCG9911_Human1.95900449
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95732803
13RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92775654
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.91077403
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89800693
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89800693
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84677423
18TAF15_26573619_Chip-Seq_HEK293_Human1.83607332
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79211126
20EZH2_22144423_ChIP-Seq_EOC_Human1.79124436
21IGF1R_20145208_ChIP-Seq_DFB_Human1.78307332
22ER_23166858_ChIP-Seq_MCF-7_Human1.77846722
23EWS_26573619_Chip-Seq_HEK293_Human1.75731257
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75660321
25FUS_26573619_Chip-Seq_HEK293_Human1.74572104
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73834703
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72151302
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70946740
29POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70946740
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70569440
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68882818
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.68750010
33AR_21572438_ChIP-Seq_LNCaP_Human1.68467679
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68115503
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66889006
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66555936
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.62679358
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62190579
39CJUN_26792858_Chip-Seq_BT549_Human1.60389925
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58124924
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57826890
42REST_21632747_ChIP-Seq_MESCs_Mouse1.54561890
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53710745
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53675735
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53531351
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.52842021
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51918177
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.49930799
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48132702
50TP53_16413492_ChIP-PET_HCT116_Human1.46974878
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46133289
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43869927
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43061763
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.41707642
55DROSHA_22980978_ChIP-Seq_HELA_Human1.40809790
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40681895
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38450011
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.37990481
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.36998023
60* RUNX2_22187159_ChIP-Seq_PCA_Human1.35557781
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35205771
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.33996255
63AHR_22903824_ChIP-Seq_MCF-7_Human1.33153718
64* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30949637
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28157721
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27763651
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27763651
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27369068
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26906129
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25747728
71STAT3_23295773_ChIP-Seq_U87_Human1.25741962
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25719251
73RNF2_27304074_Chip-Seq_NSC_Mouse1.25231439
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25205024
75TCF4_22108803_ChIP-Seq_LS180_Human1.23740336
76SOX2_19829295_ChIP-Seq_ESCs_Human1.23736966
77NANOG_19829295_ChIP-Seq_ESCs_Human1.23736966
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.23688927
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.23613404
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.23455465
81* FOXA1_25329375_ChIP-Seq_VCAP_Human1.22237816
82* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22237816
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20412155
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20161971
85KDM2B_26808549_Chip-Seq_REH_Human1.19891365
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.18551439
87ZNF263_19887448_ChIP-Seq_K562_Human1.18520571
88CBP_20019798_ChIP-Seq_JUKART_Human1.18467549
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18467549
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18406699
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17307790
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17095817
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16825886
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16548103
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15974289
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15507624
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14363134
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13751611
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.12276269
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11970173
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.11527467
102ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10520117
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.10252344
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.09164275
105TP53_22573176_ChIP-Seq_HFKS_Human1.07713387
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07667065
107* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06484504
108* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06422951
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.05771780
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05062775
111* GATA3_21878914_ChIP-Seq_MCF-7_Human1.05037761
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03715811
113TP53_18474530_ChIP-ChIP_U2OS_Human1.02979882
114* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02567098
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01848831
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.01676622
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01535359
118* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00384891
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00081958
120AR_20517297_ChIP-Seq_VCAP_Human0.99769355
121* AR_19668381_ChIP-Seq_PC3_Human0.99661350
122IRF1_19129219_ChIP-ChIP_H3396_Human0.99134535
123HOXB7_26014856_ChIP-Seq_BT474_Human0.98266455
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.97625038
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97024819
126RXR_22108803_ChIP-Seq_LS180_Human0.96962572
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96844355
128P300_19829295_ChIP-Seq_ESCs_Human0.96698011
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96641006
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.96433290
131SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95615514
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95042402
133AR_25329375_ChIP-Seq_VCAP_Human0.94878949
134SMAD4_21741376_ChIP-Seq_HESCs_Human0.94039317
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93570234
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91772667
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.90835116
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90128598
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.90031339
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89881666
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89167314
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88901995
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.88349451
144BCAT_22108803_ChIP-Seq_LS180_Human0.88279138
145KDM2B_26808549_Chip-Seq_K562_Human0.88135511
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88119061
147* TCF4_23295773_ChIP-Seq_U87_Human0.88028372
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87116112
149TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86938479
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.84989418
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84311980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.93034188
2MP0004272_abnormal_basement_membrane5.64300821
3MP0005275_abnormal_skin_tensile4.26675025
4MP0003045_fibrosis3.95843904
5MP0005503_abnormal_tendon_morphology3.95236668
6MP0001968_abnormal_touch/_nociception3.56927412
7MP0004858_abnormal_nervous_system3.45168328
8MP0003195_calcinosis3.42882612
9MP0005623_abnormal_meninges_morphology3.42085209
10MP0003136_yellow_coat_color3.31502573
11MP0002653_abnormal_ependyma_morphology3.11807241
12MP0000751_myopathy3.04498152
13MP0000920_abnormal_myelination2.56457865
14MP0008875_abnormal_xenobiotic_pharmacok2.55423238
15MP0002735_abnormal_chemical_nociception2.54780701
16MP0003279_aneurysm2.31804802
17MP0004133_heterotaxia2.29772688
18MP0005551_abnormal_eye_electrophysiolog2.28745815
19MP0004043_abnormal_pH_regulation2.25310144
20MP0002734_abnormal_mechanical_nocicepti2.21109641
21MP0009745_abnormal_behavioral_response2.11621871
22MP0001958_emphysema2.08386605
23MP0000749_muscle_degeneration2.03841435
24MP0008877_abnormal_DNA_methylation2.03528462
25MP0002733_abnormal_thermal_nociception2.00299517
26MP0001485_abnormal_pinna_reflex2.00115571
27MP0000013_abnormal_adipose_tissue1.99967878
28MP0002736_abnormal_nociception_after1.99464669
29MP0003634_abnormal_glial_cell1.98176614
30MP0002168_other_aberrant_phenotype1.94574395
31MP0000427_abnormal_hair_cycle1.93886118
32MP0003646_muscle_fatigue1.93677833
33MP0004142_abnormal_muscle_tone1.92855081
34MP0008260_abnormal_autophagy1.91311559
35MP0004885_abnormal_endolymph1.91298338
36MP0002108_abnormal_muscle_morphology1.91145575
37MP0000747_muscle_weakness1.85080885
38MP0001986_abnormal_taste_sensitivity1.84015084
39MP0002102_abnormal_ear_morphology1.77235697
40MP0001501_abnormal_sleep_pattern1.76750586
41MP0001661_extended_life_span1.74857422
42MP0000383_abnormal_hair_follicle1.73083620
43MP0005171_absent_coat_pigmentation1.71582519
44MP0008872_abnormal_physiological_respon1.69903479
45MP0004147_increased_porphyrin_level1.69582858
46MP0004270_analgesia1.68383950
47MP0002837_dystrophic_cardiac_calcinosis1.66852828
48MP0000631_abnormal_neuroendocrine_gland1.64409886
49MP0006292_abnormal_olfactory_placode1.62834477
50MP0002876_abnormal_thyroid_physiology1.61814104
51MP0002638_abnormal_pupillary_reflex1.60060621
52MP0001486_abnormal_startle_reflex1.57008039
53MP0004742_abnormal_vestibular_system1.55742723
54MP0004145_abnormal_muscle_electrophysio1.53054046
55MP0002277_abnormal_respiratory_mucosa1.51304940
56MP0009384_cardiac_valve_regurgitation1.50809006
57MP0002064_seizures1.50687177
58MP0002572_abnormal_emotion/affect_behav1.46070595
59MP0003705_abnormal_hypodermis_morpholog1.45415172
60MP0003890_abnormal_embryonic-extraembry1.44969957
61MP0000750_abnormal_muscle_regeneration1.41666266
62MP0003880_abnormal_central_pattern1.39284156
63MP0005187_abnormal_penis_morphology1.37344602
64MP0005253_abnormal_eye_physiology1.37236283
65MP0002060_abnormal_skin_morphology1.36320170
66MP0005645_abnormal_hypothalamus_physiol1.35192989
67MP0001984_abnormal_olfaction1.34121986
68MP0001970_abnormal_pain_threshold1.33575254
69MP0002557_abnormal_social/conspecific_i1.33572506
70MP0001299_abnormal_eye_distance/1.32826601
71MP0002751_abnormal_autonomic_nervous1.32276486
72MP0002928_abnormal_bile_duct1.28795023
73MP0000372_irregular_coat_pigmentation1.27490099
74MP0000462_abnormal_digestive_system1.27305794
75MP0002067_abnormal_sensory_capabilities1.25513176
76MP0003635_abnormal_synaptic_transmissio1.21461417
77MP0002272_abnormal_nervous_system1.20625874
78MP0002063_abnormal_learning/memory/cond1.20441868
79MP0006072_abnormal_retinal_apoptosis1.19637874
80MP0005257_abnormal_intraocular_pressure1.19057511
81MP0003283_abnormal_digestive_organ1.18596227
82MP0006276_abnormal_autonomic_nervous1.16976510
83MP0003315_abnormal_perineum_morphology1.16704535
84MP0000026_abnormal_inner_ear1.15732159
85MP0005646_abnormal_pituitary_gland1.15506332
86MP0003011_delayed_dark_adaptation1.12992137
87MP0005508_abnormal_skeleton_morphology1.12356300
88MP0002160_abnormal_reproductive_system1.10538523
89MP0004924_abnormal_behavior1.09566463
90MP0005386_behavior/neurological_phenoty1.09566463
91MP0003632_abnormal_nervous_system1.08464856
92MP0001270_distended_abdomen1.07979487
93MP0003137_abnormal_impulse_conducting1.07821087
94MP0009780_abnormal_chondrocyte_physiolo1.07500464
95MP0000230_abnormal_systemic_arterial1.07214696
96MP0001664_abnormal_digestion1.06930628
97MP0003566_abnormal_cell_adhesion1.04600520
98MP0002896_abnormal_bone_mineralization1.02465915
99MP0001963_abnormal_hearing_physiology1.01718380
100MP0002877_abnormal_melanocyte_morpholog1.00874876
101MP0008995_early_reproductive_senescence1.00477841
102MP0005195_abnormal_posterior_eye0.99451772
103MP0003631_nervous_system_phenotype0.99335214
104MP0003329_amyloid_beta_deposits0.99310089
105MP0002938_white_spotting0.96642102
106MP0002909_abnormal_adrenal_gland0.96294934
107MP0003950_abnormal_plasma_membrane0.95652069
108MP0000647_abnormal_sebaceous_gland0.95296279
109MP0002089_abnormal_postnatal_growth/wei0.94547689
110MP0008569_lethality_at_weaning0.93841195
111MP0003119_abnormal_digestive_system0.93132411
112MP0001324_abnormal_eye_pigmentation0.92424801
113MP0003878_abnormal_ear_physiology0.91239182
114MP0005377_hearing/vestibular/ear_phenot0.91239182
115MP0009250_abnormal_appendicular_skeleto0.90680869
116MP0010771_integument_phenotype0.90203973
117MP0009379_abnormal_foot_pigmentation0.90105494
118MP0005423_abnormal_somatic_nervous0.89817789
119MP0003633_abnormal_nervous_system0.89644872
120MP0004215_abnormal_myocardial_fiber0.89612572
121MP0002234_abnormal_pharynx_morphology0.89463604
122MP0003091_abnormal_cell_migration0.89212207
123MP0005174_abnormal_tail_pigmentation0.89156739
124MP0003718_maternal_effect0.88318824
125MP0001529_abnormal_vocalization0.85137130
126MP0001293_anophthalmia0.84869248
127MP0002163_abnormal_gland_morphology0.84783091
128MP0009046_muscle_twitch0.84297897
129MP0001502_abnormal_circadian_rhythm0.84125008
130MP0003698_abnormal_male_reproductive0.83892324
131MP0005389_reproductive_system_phenotype0.83483963
132MP0003300_gastrointestinal_ulcer0.81299548
133MP0001348_abnormal_lacrimal_gland0.80534661
134MP0001905_abnormal_dopamine_level0.79216310
135MP0003879_abnormal_hair_cell0.79131859
136MP0002752_abnormal_somatic_nervous0.78795971
137MP0003959_abnormal_lean_body0.77180747
138MP0004811_abnormal_neuron_physiology0.75919840
139MP0005670_abnormal_white_adipose0.75911453
140MP0002269_muscular_atrophy0.75301569
141MP0001440_abnormal_grooming_behavior0.74751389
142MP0000566_synostosis0.73966263
143MP0001756_abnormal_urination0.73736413
144MP0004484_altered_response_of0.73505070
145MP0002229_neurodegeneration0.73012721
146MP0000049_abnormal_middle_ear0.72812309
147MP0004381_abnormal_hair_follicle0.72487763
148MP0000733_abnormal_muscle_development0.71938215
149MP0010386_abnormal_urinary_bladder0.70344775
150MP0002295_abnormal_pulmonary_circulatio0.70026488
151MP0005410_abnormal_fertilization0.68489093
152MP0000003_abnormal_adipose_tissue0.68051393
153MP0005369_muscle_phenotype0.65937634
154MP0003385_abnormal_body_wall0.64049172
155MP0004134_abnormal_chest_morphology0.63976981
156MP0000678_abnormal_parathyroid_gland0.60066069
157MP0000759_abnormal_skeletal_muscle0.58811917
158MP0005395_other_phenotype0.58792738
159MP0002184_abnormal_innervation0.58384357
160MP0004087_abnormal_muscle_fiber0.57780282
161MP0000767_abnormal_smooth_muscle0.56369431
162MP0004130_abnormal_muscle_cell0.56253066
163MP0000569_abnormal_digit_pigmentation0.53745705
164MP0004883_abnormal_blood_vessel0.52991036
165MP0000428_abnormal_craniofacial_morphol0.52040813
166MP0000778_abnormal_nervous_system0.51642761
167MP0000579_abnormal_nail_morphology0.51144897
168MP0004233_abnormal_muscle_weight0.49698690
169MP0005375_adipose_tissue_phenotype0.48519149
170MP0004859_abnormal_synaptic_plasticity0.48336355
171MP0000955_abnormal_spinal_cord0.47757585
172MP0002106_abnormal_muscle_physiology0.47664857
173MP0000538_abnormal_urinary_bladder0.46731806
174MP0002115_abnormal_skeleton_extremities0.46706100
175MP0004185_abnormal_adipocyte_glucose0.46475134
176MP0001188_hyperpigmentation0.44668726
177MP0000534_abnormal_ureter_morphology0.44027249
178MP0004036_abnormal_muscle_relaxation0.43201870

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)8.81716800
2Insidious onset (HP:0003587)8.81716800
3Impaired proprioception (HP:0010831)8.58893671
4Action tremor (HP:0002345)7.00776654
5Increased CSF protein (HP:0002922)6.06417615
6Upper limb muscle weakness (HP:0003484)5.93249011
7Onion bulb formation (HP:0003383)5.57840148
8Steppage gait (HP:0003376)5.42583369
9Absent/shortened dynein arms (HP:0200106)5.24883273
10Dynein arm defect of respiratory motile cilia (HP:0012255)5.24883273
11Decreased number of peripheral myelinated nerve fibers (HP:0003380)5.10936575
12Hammertoe (HP:0001765)5.07844103
13Pancreatic cysts (HP:0001737)4.94044036
14Abnormal respiratory epithelium morphology (HP:0012253)4.87154910
15Abnormal respiratory motile cilium morphology (HP:0005938)4.87154910
16True hermaphroditism (HP:0010459)4.86078264
17Pancreatic fibrosis (HP:0100732)4.85554537
18Abnormality of midbrain morphology (HP:0002418)4.84159525
19Molar tooth sign on MRI (HP:0002419)4.84159525
20Abnormal ciliary motility (HP:0012262)4.83746174
21Peripheral hypomyelination (HP:0007182)4.80680098
22Premature rupture of membranes (HP:0001788)4.44426249
23Decreased motor nerve conduction velocity (HP:0003431)4.44080395
24Foot dorsiflexor weakness (HP:0009027)4.40408468
25Abnormal respiratory motile cilium physiology (HP:0012261)4.37265079
26Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.31502092
27Atrophic scars (HP:0001075)4.28473078
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.27736444
29Peripheral demyelination (HP:0011096)4.26615051
30Abnormality of the vocal cords (HP:0008777)4.19182919
31Nephronophthisis (HP:0000090)4.06230227
32Abnormality of the foot musculature (HP:0001436)3.99409087
33Postural tremor (HP:0002174)3.98854023
34Protrusio acetabuli (HP:0003179)3.84869911
35Tubular atrophy (HP:0000092)3.64623492
36Hyperventilation (HP:0002883)3.63820523
37Cystic liver disease (HP:0006706)3.60615551
38Rhinitis (HP:0012384)3.55789743
39Fragile skin (HP:0001030)3.54980539
40Abnormal pupillary function (HP:0007686)3.51042407
41Bladder diverticulum (HP:0000015)3.41599150
42Abnormality of calcium-phosphate metabolism (HP:0100530)3.38224801
43Abnormality of the renal medulla (HP:0100957)3.37877396
44Congenital stationary night blindness (HP:0007642)3.34319157
45Concave nail (HP:0001598)3.20523517
46Chronic hepatic failure (HP:0100626)3.18573214
47Ankle contracture (HP:0006466)3.18277188
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14532870
49Abnormality of alanine metabolism (HP:0010916)3.14532870
50Hyperalaninemia (HP:0003348)3.14532870
51Aortic dissection (HP:0002647)3.11055582
52Inability to walk (HP:0002540)3.02921246
53Furrowed tongue (HP:0000221)2.97347841
54Cerebral aneurysm (HP:0004944)2.94687605
55Large for gestational age (HP:0001520)2.94574515
56Genetic anticipation (HP:0003743)2.88234192
57Abnormality of the renal cortex (HP:0011035)2.87834139
58Soft skin (HP:0000977)2.87117712
59Progressive sensorineural hearing impairment (HP:0000408)2.84564682
60Sclerocornea (HP:0000647)2.82562999
61Medial flaring of the eyebrow (HP:0010747)2.80145783
62Congenital, generalized hypertrichosis (HP:0004540)2.79813943
63Decreased central vision (HP:0007663)2.78517138
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.73892502
65Anencephaly (HP:0002323)2.69468149
66Congenital hepatic fibrosis (HP:0002612)2.68844067
67Birth length less than 3rd percentile (HP:0003561)2.62978662
68Clumsiness (HP:0002312)2.61414933
69Attenuation of retinal blood vessels (HP:0007843)2.58243103
70Distal sensory impairment (HP:0002936)2.57794953
71Abolished electroretinogram (ERG) (HP:0000550)2.55531740
72Progressive cerebellar ataxia (HP:0002073)2.54619983
73Bronchiectasis (HP:0002110)2.52199193
74Type II lissencephaly (HP:0007260)2.50123438
75Bowel diverticulosis (HP:0005222)2.49878979
76Protruding tongue (HP:0010808)2.46735965
77Gait imbalance (HP:0002141)2.46641707
78Male pseudohermaphroditism (HP:0000037)2.43915119
79Bile duct proliferation (HP:0001408)2.42310703
80Abnormal biliary tract physiology (HP:0012439)2.42310703
81Postaxial foot polydactyly (HP:0001830)2.41389383
82Thin bony cortex (HP:0002753)2.38920356
83Polydipsia (HP:0001959)2.38717193
84Abnormal drinking behavior (HP:0030082)2.38717193
85Occipital encephalocele (HP:0002085)2.38409032
86Progressive inability to walk (HP:0002505)2.37354097
87Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.37240433
88Progressive hearing impairment (HP:0001730)2.36917722
89Congenital primary aphakia (HP:0007707)2.34692346
90Dilatation of the ascending aorta (HP:0005111)2.31116074
91Decreased circulating renin level (HP:0003351)2.30968721
92Chronic bronchitis (HP:0004469)2.30765393
93Sex reversal (HP:0012245)2.29235659
94Abnormal sex determination (HP:0012244)2.29235659
95Peritonitis (HP:0002586)2.28717038
96Gaze-evoked nystagmus (HP:0000640)2.28566516
97Broad metatarsal (HP:0001783)2.24384232
98Renovascular hypertension (HP:0100817)2.23817602
99Hypoplasia of the uterus (HP:0000013)2.21701914
100Hypoventilation (HP:0002791)2.21686212
101Striae distensae (HP:0001065)2.14539893
102Prominent supraorbital ridges (HP:0000336)2.14023199
103Mitral valve prolapse (HP:0001634)2.13832834
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.13484319
105Broad-based gait (HP:0002136)2.13367171
106Genital tract atresia (HP:0001827)2.10871721
107Hypoplastic ischia (HP:0003175)2.10601823
108Hypomagnesemia (HP:0002917)2.07556424
109Pendular nystagmus (HP:0012043)2.06999173
110Vaginal atresia (HP:0000148)2.06259419
111Overgrowth (HP:0001548)2.05672826
112Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04628591
113Patellar aplasia (HP:0006443)2.02926184
114Nephrogenic diabetes insipidus (HP:0009806)2.00713942
115Ulnar claw (HP:0001178)13.7554430
116Segmental peripheral demyelination/remyelination (HP:0003481)11.1722892
117Fair hair (HP:0002286)1.96996343
118Follicular hyperkeratosis (HP:0007502)1.96647823
119Spinal rigidity (HP:0003306)1.96410146
120Kyphoscoliosis (HP:0002751)1.96168603
121Partial agenesis of the corpus callosum (HP:0001338)1.93561497
122Alopecia of scalp (HP:0002293)1.90476252
123Preaxial hand polydactyly (HP:0001177)1.89581701
124Aplasia/Hypoplasia of the patella (HP:0006498)1.89117803
125Abnormality of the ischium (HP:0003174)1.88155342
126Shallow orbits (HP:0000586)1.87970959
127Febrile seizures (HP:0002373)1.87490955
128Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86297535
129Bony spicule pigmentary retinopathy (HP:0007737)1.85707060
130Poor coordination (HP:0002370)1.84363264
131Spastic tetraparesis (HP:0001285)1.84110631
132Polyuria (HP:0000103)1.83533910
133Abnormality of dentin (HP:0010299)1.81126517
134Oculomotor apraxia (HP:0000657)1.80511229
135Wrist flexion contracture (HP:0001239)1.78669297
136Tubulointerstitial fibrosis (HP:0005576)1.78332717
137Genu recurvatum (HP:0002816)1.76427920
138Difficulty walking (HP:0002355)1.76218562
139Postaxial hand polydactyly (HP:0001162)1.76206810
140Abnormal rod and cone electroretinograms (HP:0008323)1.76120973
141Neonatal short-limb short stature (HP:0008921)1.76016024
142Abnormality of magnesium homeostasis (HP:0004921)1.75612623
143Hyperextensible skin (HP:0000974)1.75390581
144Widely spaced teeth (HP:0000687)1.73852669
145Confusion (HP:0001289)1.72225623
146Aortic aneurysm (HP:0004942)1.72149173
147Hypercortisolism (HP:0001578)1.71636496
148Congenital sensorineural hearing impairment (HP:0008527)1.71626559
149Type 1 muscle fiber predominance (HP:0003803)1.71335303
150Morphological abnormality of the pyramidal tract (HP:0002062)1.70783727
151Abnormality of renin-angiotensin system (HP:0000847)1.69536884
152Increased corneal curvature (HP:0100692)1.68824642
153Keratoconus (HP:0000563)1.68824642
154Optic nerve hypoplasia (HP:0000609)1.67959127
155Tubulointerstitial abnormality (HP:0001969)1.66493417
156Renal cortical cysts (HP:0000803)1.66330835
157Germ cell neoplasia (HP:0100728)1.66239403
158Absent speech (HP:0001344)1.65326157
159Increased variability in muscle fiber diameter (HP:0003557)1.64667598
160Supernumerary spleens (HP:0009799)1.64521393
161Chorioretinal atrophy (HP:0000533)1.63136442
162Wormian bones (HP:0002645)1.62247099
163Cerebellar dysplasia (HP:0007033)1.62141488
164Generalized hypopigmentation of hair (HP:0011358)1.61861493
165Left ventricular hypertrophy (HP:0001712)1.60594392
166Venous insufficiency (HP:0005293)1.60563488
167Abnormality of the pubic bones (HP:0003172)1.59594570
168Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.58625494
169Blue sclerae (HP:0000592)1.58530064
170Increased connective tissue (HP:0009025)1.57857782
171Pheochromocytoma (HP:0002666)1.55246798
172Osteolytic defects of the hand bones (HP:0009699)1.53685503
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.53685503
174Venous abnormality (HP:0002624)1.49088556
175Abnormal auditory evoked potentials (HP:0006958)1.47814679
176Slender build (HP:0001533)1.42090546
177Hyporeflexia of lower limbs (HP:0002600)1.38798372
178Flat cornea (HP:0007720)1.37932038
179Joint laxity (HP:0001388)1.37505755
180Difficulty running (HP:0009046)1.36931303
181Abnormal delivery (HP:0001787)1.36880307
182Slow progression (HP:0003677)1.33811255
183Aplasia/hypoplasia of the uterus (HP:0008684)1.33130208
184Tibial bowing (HP:0002982)1.31829670
185Infantile muscular hypotonia (HP:0008947)1.29194413
186Abnormality of skeletal muscle fiber size (HP:0012084)1.28412072
187Mildly elevated creatine phosphokinase (HP:0008180)1.27599114
188Abnormality of the pupil (HP:0000615)1.26485653
189Hyperparathyroidism (HP:0000843)1.25937109
190Hypercalciuria (HP:0002150)1.23192085
191Thoracolumbar scoliosis (HP:0002944)1.23148797
192Aplasia cutis congenita (HP:0001057)1.22607668
193Enlarged penis (HP:0000040)1.22217690
194Bundle branch block (HP:0011710)1.21334255
195Vascular tortuosity (HP:0004948)1.21284793
196Cervical subluxation (HP:0003308)1.21135689
197Hyperacusis (HP:0010780)1.21089311
198Muscular dystrophy (HP:0003560)1.19011316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK24.16860908
2LMTK23.73254758
3IRAK23.41571110
4NTRK13.37526327
5BMPR1B3.26906391
6ACVR1B3.23565042
7MAPK153.20214267
8IRAK13.17898879
9RET2.97601418
10MAP3K22.83621453
11CASK2.57500267
12PRKD32.57415318
13LATS22.41748459
14GRK12.37605861
15PNCK2.25002600
16TRIB32.22403714
17TLK12.13915341
18DDR22.13870847
19STK392.13283602
20EPHB12.10929600
21ZAK2.06452869
22LIMK11.94093924
23KSR21.89270338
24WNK41.88805764
25NTRK31.87257965
26TAOK31.86052910
27PDGFRA1.85737466
28DAPK21.81980760
29WNK31.81403745
30TTN1.77615626
31FRK1.77255045
32EPHA31.67976571
33INSRR1.67212225
34WNK11.58410376
35MAP3K41.57582584
36NUAK11.50086770
37TGFBR11.49993333
38CAMK1D1.48079775
39PINK11.47112539
40PTK21.45753260
41FER1.45615802
42MAP2K11.45151665
43MAP4K21.41781507
44PTK2B1.41525967
45PKN21.40969609
46OXSR11.37988399
47RPS6KA21.37816223
48PAK61.37027363
49EPHB21.34983512
50MINK11.28118245
51MARK21.27224160
52PIK3CA1.24934914
53NEK91.23816827
54PAK31.17518892
55MATK1.13388947
56SIK11.12451226
57RIPK11.10588241
58PTK61.10489527
59PHKG21.09182043
60PHKG11.09182043
61PRKCH1.07951438
62MKNK21.07798724
63MAP3K91.05226165
64CAMK1G1.05211273
65TNIK1.03366458
66PRKCG0.99019309
67SCYL20.98143227
68MAPKAPK30.97152561
69OBSCN0.96576644
70ROCK10.94611907
71LATS10.94399002
72MUSK0.93182800
73PDK40.91437207
74PDK30.91437207
75CAMKK10.90042768
76ICK0.89019691
77ERBB20.85812669
78PKN10.84054574
79SGK2230.83164795
80SGK4940.83164795
81STK38L0.81736571
82CAMK2A0.80250540
83MAPK130.79839046
84CDC42BPA0.78755440
85PLK20.78050319
86NTRK20.75456432
87PDGFRB0.74295167
88CAMKK20.69826032
89NEK20.69240753
90CDK50.67438161
91MAP2K70.67038203
92MET0.66827207
93WEE10.65537885
94TIE10.65198036
95BMX0.63989149
96MAPKAPK50.63877327
97PRKCQ0.63747385
98CDK30.63100029
99TXK0.63048432
100VRK10.62252003
101PRKCE0.62117045
102PRKD10.60721933
103MAP2K20.60693788
104UHMK10.59819558
105MARK30.58557347
106JAK10.56641172
107GRK50.56286331
108RPS6KA50.55405308
109PRKACA0.54880467
110SGK30.54717515
111DYRK20.53723507
112ADRBK10.53389925
113MAP2K60.53128886
114PDPK10.52869846
115CDK80.52599324
116ROCK20.51501221
117CHUK0.51417499
118CAMK10.50054931
119ILK0.49933949
120DYRK1B0.49579703
121PRKAA10.49564192
122PRKAA20.47998064
123SRC0.47109341
124GSK3A0.46918924
125MAP2K40.45827315
126TRPM70.45248007
127MAP3K10.44998795
128NLK0.44257192
129MTOR0.43747525
130STK240.42835350
131ARAF0.41821819
132MARK10.41805868
133TEC0.41476247
134PRKG10.40083199
135CSNK1G20.39981175
136FGFR30.39697334
137PIK3CG0.39388843
138HIPK20.39312658
139PRKCZ0.39041924
140STK30.38703023
141PRKCA0.38289158
142STK380.37625915
143FYN0.36516814
144PDK20.36490157
145SGK20.34496325
146PDK10.34264825
147INSR0.34005729
148PRKG20.33754474
149NME10.33517327
150KIT0.33163358
151SIK20.31560794
152STK110.31400724
153PAK20.31339314
154IKBKB0.30679886
155PRKACB0.30674345
156CAMK2B0.30638994
157BCR0.29965665
158LRRK20.29936901
159MKNK10.29930212
160MAPK100.29719231
161FGFR20.29408141
162MAP3K70.29372339
163BRSK20.29350629
164DYRK1A0.29243875
165CSNK1D0.29084156
166CSNK1A10.28781125
167TESK10.28734858
168RPS6KA60.28047948
169MELK0.27430472
170CSNK1G10.26573558

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.71141896
2Linoleic acid metabolism_Homo sapiens_hsa005913.19174610
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.97793243
4Nicotine addiction_Homo sapiens_hsa050332.92701451
5Butanoate metabolism_Homo sapiens_hsa006502.64964372
6Phototransduction_Homo sapiens_hsa047442.62518192
7Nitrogen metabolism_Homo sapiens_hsa009102.59175723
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.37110652
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.36138811
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.27372635
11Protein digestion and absorption_Homo sapiens_hsa049742.24325473
12Focal adhesion_Homo sapiens_hsa045102.17223333
13Ether lipid metabolism_Homo sapiens_hsa005652.12569990
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.09454107
15Selenocompound metabolism_Homo sapiens_hsa004502.07065190
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.99929504
17Amoebiasis_Homo sapiens_hsa051461.92586198
18Dilated cardiomyopathy_Homo sapiens_hsa054141.90043161
19ABC transporters_Homo sapiens_hsa020101.88573676
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.83544796
21Dorso-ventral axis formation_Homo sapiens_hsa043201.80846476
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79317571
23Caffeine metabolism_Homo sapiens_hsa002321.77573925
24Steroid biosynthesis_Homo sapiens_hsa001001.72957111
25Chemical carcinogenesis_Homo sapiens_hsa052041.72724649
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65003710
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61174348
28Histidine metabolism_Homo sapiens_hsa003401.59613003
29Tryptophan metabolism_Homo sapiens_hsa003801.55353848
30Axon guidance_Homo sapiens_hsa043601.54416343
31Insulin secretion_Homo sapiens_hsa049111.51685347
32Small cell lung cancer_Homo sapiens_hsa052221.47895498
33Morphine addiction_Homo sapiens_hsa050321.47248636
34Hedgehog signaling pathway_Homo sapiens_hsa043401.47208742
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46250771
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45701949
37Viral myocarditis_Homo sapiens_hsa054161.45611147
38Arachidonic acid metabolism_Homo sapiens_hsa005901.44658845
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43836472
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43105445
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42365917
42Glioma_Homo sapiens_hsa052141.37558668
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.37054786
44Cardiac muscle contraction_Homo sapiens_hsa042601.36415474
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.29833626
46Retinol metabolism_Homo sapiens_hsa008301.28623421
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27603277
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26508996
49Endometrial cancer_Homo sapiens_hsa052131.26486151
50Estrogen signaling pathway_Homo sapiens_hsa049151.24462220
51Tight junction_Homo sapiens_hsa045301.22110679
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19359708
53Calcium signaling pathway_Homo sapiens_hsa040201.18573172
54Serotonergic synapse_Homo sapiens_hsa047261.17988333
55GABAergic synapse_Homo sapiens_hsa047271.16672275
56Oxidative phosphorylation_Homo sapiens_hsa001901.13648225
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12291400
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12186515
59Cholinergic synapse_Homo sapiens_hsa047251.11319916
60Prion diseases_Homo sapiens_hsa050201.11079763
61Peroxisome_Homo sapiens_hsa041461.09895318
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09766500
63Thyroid cancer_Homo sapiens_hsa052161.08715156
64Proteoglycans in cancer_Homo sapiens_hsa052051.08667977
65Toxoplasmosis_Homo sapiens_hsa051451.07983648
66beta-Alanine metabolism_Homo sapiens_hsa004101.04080349
67Melanoma_Homo sapiens_hsa052181.03897820
68Fatty acid metabolism_Homo sapiens_hsa012121.02666224
69Taste transduction_Homo sapiens_hsa047421.02543734
70GnRH signaling pathway_Homo sapiens_hsa049121.01649707
71Basal transcription factors_Homo sapiens_hsa030221.01445106
72Dopaminergic synapse_Homo sapiens_hsa047280.99634651
73Prolactin signaling pathway_Homo sapiens_hsa049170.99398059
74ErbB signaling pathway_Homo sapiens_hsa040120.97822699
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97773478
76Gap junction_Homo sapiens_hsa045400.97714141
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97385558
78Adherens junction_Homo sapiens_hsa045200.96838611
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94597332
80Melanogenesis_Homo sapiens_hsa049160.94295981
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.93922615
82Huntingtons disease_Homo sapiens_hsa050160.93820783
83Cocaine addiction_Homo sapiens_hsa050300.93262352
84Chronic myeloid leukemia_Homo sapiens_hsa052200.93210913
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92197256
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91945594
87Vitamin digestion and absorption_Homo sapiens_hsa049770.91775155
88Insulin signaling pathway_Homo sapiens_hsa049100.91099087
89Synaptic vesicle cycle_Homo sapiens_hsa047210.90681037
90Glucagon signaling pathway_Homo sapiens_hsa049220.90419894
91Bladder cancer_Homo sapiens_hsa052190.89942919
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.86612774
93Platelet activation_Homo sapiens_hsa046110.86280580
94Renin secretion_Homo sapiens_hsa049240.86186049
95Fatty acid biosynthesis_Homo sapiens_hsa000610.86072082
96Homologous recombination_Homo sapiens_hsa034400.85557176
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85404718
98Type II diabetes mellitus_Homo sapiens_hsa049300.85252827
99Circadian entrainment_Homo sapiens_hsa047130.85245016
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84893959
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84126863
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83176309
103Gastric acid secretion_Homo sapiens_hsa049710.82216486
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81353538
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.76138708
106Fat digestion and absorption_Homo sapiens_hsa049750.76041796
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75356586
108Rap1 signaling pathway_Homo sapiens_hsa040150.74435035
109Long-term depression_Homo sapiens_hsa047300.73950518
110Parkinsons disease_Homo sapiens_hsa050120.73901117
111Ras signaling pathway_Homo sapiens_hsa040140.73296149
112cAMP signaling pathway_Homo sapiens_hsa040240.73213588
113Glycerolipid metabolism_Homo sapiens_hsa005610.73009940
114Thyroid hormone synthesis_Homo sapiens_hsa049180.72913147
115Long-term potentiation_Homo sapiens_hsa047200.72891720
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.72639659
117Hippo signaling pathway_Homo sapiens_hsa043900.71781094
118Salivary secretion_Homo sapiens_hsa049700.71550089
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69542513
120VEGF signaling pathway_Homo sapiens_hsa043700.69334893
121Mineral absorption_Homo sapiens_hsa049780.68264082
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67637243
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.67568137
124Pathways in cancer_Homo sapiens_hsa052000.67029832
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.66733843
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66394335
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.65428655
128Insulin resistance_Homo sapiens_hsa049310.64805650
129Fatty acid degradation_Homo sapiens_hsa000710.64668446
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62808742
131PPAR signaling pathway_Homo sapiens_hsa033200.62445570
132Pancreatic cancer_Homo sapiens_hsa052120.62138188
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61976180
134Fanconi anemia pathway_Homo sapiens_hsa034600.60243671
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59634050
136MicroRNAs in cancer_Homo sapiens_hsa052060.59297565
137Oxytocin signaling pathway_Homo sapiens_hsa049210.59230152
138Bile secretion_Homo sapiens_hsa049760.58567226
139Wnt signaling pathway_Homo sapiens_hsa043100.58263755
140Glutamatergic synapse_Homo sapiens_hsa047240.57551673
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.56265736
142Sulfur relay system_Homo sapiens_hsa041220.55794412
143Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55500674
144Ovarian steroidogenesis_Homo sapiens_hsa049130.55412372
145Alzheimers disease_Homo sapiens_hsa050100.54373389
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.54071952
147Prostate cancer_Homo sapiens_hsa052150.53288069
148Renin-angiotensin system_Homo sapiens_hsa046140.51903824
149AMPK signaling pathway_Homo sapiens_hsa041520.51386548
150Amphetamine addiction_Homo sapiens_hsa050310.50784562
151Endocytosis_Homo sapiens_hsa041440.49984787
152Salmonella infection_Homo sapiens_hsa051320.49613717
153Olfactory transduction_Homo sapiens_hsa047400.49392249
154Pancreatic secretion_Homo sapiens_hsa049720.48771737
155Circadian rhythm_Homo sapiens_hsa047100.48724269
156Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47720862
157Propanoate metabolism_Homo sapiens_hsa006400.46840710
158Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46063585
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.45237533
160Basal cell carcinoma_Homo sapiens_hsa052170.44340027
161Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43731787
162Sphingolipid metabolism_Homo sapiens_hsa006000.43128646
163Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41351452
164Collecting duct acid secretion_Homo sapiens_hsa049660.40375721
165Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40255741
166Regulation of autophagy_Homo sapiens_hsa041400.39136448
167Metabolic pathways_Homo sapiens_hsa011000.37449077
168Protein export_Homo sapiens_hsa030600.36303213
169RNA polymerase_Homo sapiens_hsa030200.35137194
170One carbon pool by folate_Homo sapiens_hsa006700.32327179
171Tyrosine metabolism_Homo sapiens_hsa003500.31744653

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »