COL4A3BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.19816436
2detection of molecule of bacterial origin (GO:0032490)4.15835733
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.95797598
4positive regulation by organism of defense response of other organism involved in symbiotic interact3.95797598
5modulation by symbiont of host immune response (GO:0052553)3.95797598
6positive regulation by symbiont of host defense response (GO:0052509)3.95797598
7modulation by symbiont of host defense response (GO:0052031)3.95797598
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.95797598
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.75919142
10protein localization to endosome (GO:0036010)3.63465949
11cellular extravasation (GO:0045123)3.61400474
12positive regulation of gamma-delta T cell activation (GO:0046645)3.59523258
13sodium ion export (GO:0071436)3.56951660
14regulation of interferon-beta biosynthetic process (GO:0045357)3.47482045
15macrophage activation involved in immune response (GO:0002281)3.40069907
16regulation of ARF protein signal transduction (GO:0032012)3.35321382
17cytoplasmic mRNA processing body assembly (GO:0033962)3.33854712
18regulation of clathrin-mediated endocytosis (GO:2000369)3.33154825
19detection of other organism (GO:0098543)3.28097248
20microglial cell activation (GO:0001774)3.27902662
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24514836
22protein targeting to Golgi (GO:0000042)3.20027023
23positive regulation of mast cell activation (GO:0033005)3.14916872
24regulation of meiosis I (GO:0060631)3.14502601
25establishment of protein localization to Golgi (GO:0072600)3.11422768
26detection of external biotic stimulus (GO:0098581)3.08499689
27neutrophil mediated immunity (GO:0002446)3.07932773
28positive regulation of macrophage cytokine production (GO:0060907)3.06368568
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.01910925
30macroautophagy (GO:0016236)2.98388155
31early endosome to late endosome transport (GO:0045022)2.95202104
32retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95152243
33myeloid leukocyte mediated immunity (GO:0002444)2.93831591
34Rap protein signal transduction (GO:0032486)2.92079536
35synaptic vesicle maturation (GO:0016188)2.91876082
36response to peptidoglycan (GO:0032494)2.91422164
37negative regulation of T cell mediated immunity (GO:0002710)2.91172874
38positive regulation of mast cell degranulation (GO:0043306)2.90985449
39positive regulation of mast cell activation involved in immune response (GO:0033008)2.90985449
40cellular potassium ion homeostasis (GO:0030007)2.90133860
41growth hormone receptor signaling pathway (GO:0060396)2.87955303
42Golgi to endosome transport (GO:0006895)2.87917009
43cellular response to thyroid hormone stimulus (GO:0097067)2.87846305
44negative regulation of interleukin-12 production (GO:0032695)2.84493354
45neutrophil activation involved in immune response (GO:0002283)2.83442410
46response to host immune response (GO:0052572)2.82911151
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82911151
48interleukin-6-mediated signaling pathway (GO:0070102)2.78599696
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78095311
50regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.76955184
51macrophage activation (GO:0042116)2.76651259
52positive regulation of histone deacetylation (GO:0031065)2.75957177
53production of molecular mediator involved in inflammatory response (GO:0002532)2.74253840
54response to hydroperoxide (GO:0033194)2.71878352
55detection of biotic stimulus (GO:0009595)2.71773882
56interferon-gamma production (GO:0032609)2.71067234
57plasma membrane repair (GO:0001778)2.70444031
58interkinetic nuclear migration (GO:0022027)2.67558286
59histone H3-K36 demethylation (GO:0070544)2.67050955
60cytoskeletal anchoring at plasma membrane (GO:0007016)2.66073985
61positive regulation of leukocyte degranulation (GO:0043302)2.64884426
62cellular response to ethanol (GO:0071361)2.64433546
63N-acetylneuraminate metabolic process (GO:0006054)2.63770894
64monoubiquitinated protein deubiquitination (GO:0035520)2.63180977
65piRNA metabolic process (GO:0034587)2.61130258
66dicarboxylic acid biosynthetic process (GO:0043650)2.59564842
67regulation of mast cell activation (GO:0033003)2.59375622
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58542577
69regulation of cholesterol homeostasis (GO:2000188)2.58367419
70negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.56899441
71positive regulation of interferon-alpha production (GO:0032727)2.56509184
72activation of protein kinase A activity (GO:0034199)2.56482237
73regulation of Rap GTPase activity (GO:0032317)2.55396412
74regulation of B cell receptor signaling pathway (GO:0050855)2.55200767
75regulation of establishment of cell polarity (GO:2000114)2.55093640
76positive regulation of cellular amide metabolic process (GO:0034250)2.54244099
77response to host (GO:0075136)2.53060805
78response to host defenses (GO:0052200)2.53060805
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53060805
80positive regulation of regulated secretory pathway (GO:1903307)2.51155100
81germinal center formation (GO:0002467)2.50989846
82cellular response to growth hormone stimulus (GO:0071378)2.50974490
83regulation of gamma-delta T cell activation (GO:0046643)2.50626825
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50447789
85regulation of mast cell activation involved in immune response (GO:0033006)2.49352156
86proline transport (GO:0015824)2.47781575
87regulation of interferon-alpha production (GO:0032647)2.47333406
88positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46519529
89locomotory exploration behavior (GO:0035641)2.45194950
90positive regulation of toll-like receptor signaling pathway (GO:0034123)2.44524775
91insulin-like growth factor receptor signaling pathway (GO:0048009)2.43571341
92negative regulation of interleukin-17 production (GO:0032700)2.43193257
93negative regulation of B cell mediated immunity (GO:0002713)2.42010857
94negative regulation of immunoglobulin mediated immune response (GO:0002890)2.42010857
95myeloid cell activation involved in immune response (GO:0002275)2.41359457
96negative regulation of NF-kappaB import into nucleus (GO:0042347)2.41300327
97potassium ion import (GO:0010107)2.40557181
98regulation of mast cell degranulation (GO:0043304)2.40100693
99detection of bacterium (GO:0016045)2.40004583
100vesicle transport along microtubule (GO:0047496)2.38969290
101negative regulation of leukocyte mediated immunity (GO:0002704)2.37739466
102negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.37418119
103negative regulation of T-helper cell differentiation (GO:0045623)2.37418119
104regulation of cAMP-dependent protein kinase activity (GO:2000479)2.37031961
105positive regulation of vesicle fusion (GO:0031340)2.36359442
106thyroid hormone metabolic process (GO:0042403)2.36245104
107cilium or flagellum-dependent cell motility (GO:0001539)2.34892365
108negative regulation of adaptive immune response (GO:0002820)2.34849427
109regulation of protein glycosylation (GO:0060049)2.34442340
110negative regulation of type 2 immune response (GO:0002829)2.33212574
111regulation of germinal center formation (GO:0002634)2.32798295
112positive regulation of p38MAPK cascade (GO:1900745)2.30422471
113hemidesmosome assembly (GO:0031581)2.29551341
114regulation of regulated secretory pathway (GO:1903305)2.28732202
115negative regulation of translation, ncRNA-mediated (GO:0040033)2.28701657
116regulation of translation, ncRNA-mediated (GO:0045974)2.28701657
117negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28701657
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.28449947
119cellular sodium ion homeostasis (GO:0006883)2.28297537
120positive regulation of interferon-beta production (GO:0032728)2.28281664
121positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.27575278
122regulation of short-term neuronal synaptic plasticity (GO:0048172)2.26018776
123cell adhesion mediated by integrin (GO:0033627)2.25789887
124relaxation of cardiac muscle (GO:0055119)2.25314803
125regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.24158325
126phospholipid homeostasis (GO:0055091)2.21410705
127alanine transport (GO:0032328)2.20332260
128alpha-linolenic acid metabolic process (GO:0036109)2.19880560
129positive regulation of glycolytic process (GO:0045821)2.19718370
130lipid translocation (GO:0034204)2.18103966
131phospholipid translocation (GO:0045332)2.18103966
132apoptotic cell clearance (GO:0043277)2.17715464
133layer formation in cerebral cortex (GO:0021819)2.17039640
134* endoplasmic reticulum organization (GO:0007029)2.16447371
135negative regulation of cell size (GO:0045792)2.14847849
136positive regulation of fatty acid beta-oxidation (GO:0032000)2.14335718
137regulation of fatty acid beta-oxidation (GO:0031998)2.13409283
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.12804729
139negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.12640340
140negative regulation of cell killing (GO:0031342)2.12640340
141positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11476748
142negative regulation of hormone biosynthetic process (GO:0032353)2.11431898
143negative regulation of hormone metabolic process (GO:0032351)2.11431898
144regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.10701401
145fatty acid transmembrane transport (GO:1902001)2.10629612
146stress fiber assembly (GO:0043149)2.10214496
147peptidyl-lysine dimethylation (GO:0018027)2.09329958
148regulation of p38MAPK cascade (GO:1900744)2.08992594
149positive regulation of glycogen biosynthetic process (GO:0045725)2.07831398
150histone H3-K9 demethylation (GO:0033169)2.06351392
151low-density lipoprotein particle clearance (GO:0034383)2.05321709
152cell communication by electrical coupling (GO:0010644)2.04567114
153regulation of ARF GTPase activity (GO:0032312)2.04388588
154Golgi transport vesicle coating (GO:0048200)2.03376153
155COPI coating of Golgi vesicle (GO:0048205)2.03376153
156protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.02867290
157urea metabolic process (GO:0019627)2.02438222
158urea cycle (GO:0000050)2.02438222
159activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.01700341
160establishment of nucleus localization (GO:0040023)2.00795050
161peptidyl-threonine modification (GO:0018210)2.00636752
162peptidyl-threonine phosphorylation (GO:0018107)2.00494765
163negative regulation of fatty acid transport (GO:2000192)1.99575451
164lysine metabolic process (GO:0006553)1.99562764
165lysine catabolic process (GO:0006554)1.99562764
166NLS-bearing protein import into nucleus (GO:0006607)1.99258356
167regulation of protein polyubiquitination (GO:1902914)1.98977613
168regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.98290902
169carnitine shuttle (GO:0006853)1.98283025
170negative regulation of lipid transport (GO:0032369)1.96799433
171clathrin coat assembly (GO:0048268)1.96353501
172lipoprotein transport (GO:0042953)1.96271518
173regulation of membrane protein ectodomain proteolysis (GO:0051043)1.95980844
174cell communication involved in cardiac conduction (GO:0086065)1.95806946
175cerebellar Purkinje cell differentiation (GO:0021702)1.94931931
176peptidyl-glutamic acid carboxylation (GO:0017187)1.94808398
177protein carboxylation (GO:0018214)1.94808398
178phospholipid dephosphorylation (GO:0046839)1.94753916
179positive regulation of Rap GTPase activity (GO:0032854)1.94708711
180regulation of Rac protein signal transduction (GO:0035020)1.94031353
181glutamate metabolic process (GO:0006536)1.93271572
182retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)1.92669734
183receptor catabolic process (GO:0032801)1.91372951
184phosphatidylinositol dephosphorylation (GO:0046856)1.89869345
185positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.89685897
186protein targeting to plasma membrane (GO:0072661)1.89652482
187cell-substrate junction assembly (GO:0007044)1.89219768
188nerve growth factor signaling pathway (GO:0038180)1.87505733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26764501
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79272985
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.58205632
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25194522
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24363857
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22443121
7GBX2_23144817_ChIP-Seq_PC3_Human2.13334160
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.12312477
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.02908916
10RXR_22158963_ChIP-Seq_LIVER_Mouse1.96757406
11IRF8_21731497_ChIP-ChIP_J774_Mouse1.93952136
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88446413
13IRF8_22096565_ChIP-ChIP_GC-B_Human1.86374416
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77527868
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76696295
16TAF15_26573619_Chip-Seq_HEK293_Human1.76295419
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75904681
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75644566
19OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73273937
20P300_19829295_ChIP-Seq_ESCs_Human1.71730222
21PPARA_22158963_ChIP-Seq_LIVER_Mouse1.70213074
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69655779
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68647409
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.68193194
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.64982627
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.64361346
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61980626
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.59128128
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59044063
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58007444
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55132656
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53085846
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.51625468
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51141246
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49146788
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49027323
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48681433
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46830969
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46805524
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46021808
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.45010492
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.44558409
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.43973561
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42952423
45GATA1_22025678_ChIP-Seq_K562_Human1.42867000
46KDM2B_26808549_Chip-Seq_K562_Human1.42391116
47DROSHA_22980978_ChIP-Seq_HELA_Human1.41611520
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39243659
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38365085
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.37835717
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37237245
52KDM2B_26808549_Chip-Seq_DND41_Human1.36680020
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34954172
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.34433149
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34015091
56FUS_26573619_Chip-Seq_HEK293_Human1.31698391
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31402334
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30890861
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29163978
60* TCF4_23295773_ChIP-Seq_U87_Human1.28399927
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.27148510
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26705102
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26705102
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26277612
65TP53_16413492_ChIP-PET_HCT116_Human1.25522596
66CLOCK_20551151_ChIP-Seq_293T_Human1.24953710
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24561711
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.23781020
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22463331
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.22347018
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21956978
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21917199
73TCF7_22412390_ChIP-Seq_EML_Mouse1.21782170
74P53_22387025_ChIP-Seq_ESCs_Mouse1.21719376
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21684923
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21120317
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.20892338
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20680991
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.20254333
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19554567
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18998340
82* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18575100
83RUNX_20019798_ChIP-Seq_JUKART_Human1.18312783
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18200588
85AHR_22903824_ChIP-Seq_MCF-7_Human1.18106027
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.17821773
87VDR_22108803_ChIP-Seq_LS180_Human1.17759446
88OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17575331
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.17292051
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16527712
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.16197104
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15106578
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14890126
94ER_23166858_ChIP-Seq_MCF-7_Human1.14584883
95P300_18555785_Chip-Seq_ESCs_Mouse1.13436569
96GATA1_19941826_ChIP-Seq_K562_Human1.13067469
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12840446
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12762259
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12292826
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.12239918
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11739816
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10957967
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10868017
104CDX2_22108803_ChIP-Seq_LS180_Human1.10817144
105SMRT_27268052_Chip-Seq_Bcells_Human1.10790968
106* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10732478
107AR_25329375_ChIP-Seq_VCAP_Human1.10463896
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09515259
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.09218891
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09059957
111RUNX2_22187159_ChIP-Seq_PCA_Human1.08898518
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08666326
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08355115
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08099455
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07932029
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07791658
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07029211
118CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06801610
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06772973
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06125644
121KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.05948873
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05782050
123WT1_19549856_ChIP-ChIP_CCG9911_Human1.05478482
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05395838
125STAT3_18555785_Chip-Seq_ESCs_Mouse1.04894679
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04136442
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03170101
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.02183761
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.02147709
130TBX20_22328084_ChIP-Seq_HEART_Mouse1.02052143
131TBX20_22080862_ChIP-Seq_HEART_Mouse1.02052143
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.01812183
133OCT4_18555785_Chip-Seq_ESCs_Mouse1.01767130
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.01674226
135RXR_22108803_ChIP-Seq_LS180_Human1.01623018
136RUNX1_27514584_Chip-Seq_MCF-7_Human1.01605758
137TRIM28_21343339_ChIP-Seq_HEK293_Human1.01039685
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00684037
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00076434
140CJUN_26792858_Chip-Seq_BT549_Human0.97574470
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96826286
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96621934
143* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96174079
144* TP63_23658742_ChIP-Seq_EP156T_Human0.96023724
145SPI1_23127762_ChIP-Seq_K562_Human0.95331633
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95033198
147GATA2_19941826_ChIP-Seq_K562_Human0.94544650
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94259902
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94259902
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94168241
151STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93615395
152BCAT_22108803_ChIP-Seq_LS180_Human0.93611938
153SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93255345
154TCF4_18268006_ChIP-ChIP_LS174T_Human0.93081662
155PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92552333
156* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92193188
157FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91737631
158SOX2_21211035_ChIP-Seq_LN229_Gbm0.91459594
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91432157
160VDR_24787735_ChIP-Seq_THP-1_Human0.90455871
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89215061
162AR_19668381_ChIP-Seq_PC3_Human0.89201287
163IRF8_27001747_Chip-Seq_BMDM_Mouse0.88853799
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.88213504
165* STAT3_23295773_ChIP-Seq_U87_Human0.87816169
166SMAD4_21799915_ChIP-Seq_A2780_Human0.87262540
167TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85894505
168FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85632715
169TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85558975
170SMAD3_21741376_ChIP-Seq_HESCs_Human0.84901001
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84357566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.65024000
2MP0003724_increased_susceptibility_to3.60747761
3MP0000569_abnormal_digit_pigmentation3.57177294
4MP0003705_abnormal_hypodermis_morpholog3.44050354
5MP0003300_gastrointestinal_ulcer3.37125738
6MP0008877_abnormal_DNA_methylation2.99202091
7MP0003787_abnormal_imprinting2.81835371
8MP0009780_abnormal_chondrocyte_physiolo2.75449802
9MP0003890_abnormal_embryonic-extraembry2.73128990
10MP0005174_abnormal_tail_pigmentation2.70779115
11MP0002139_abnormal_hepatobiliary_system2.62076766
12MP0005360_urolithiasis2.61664380
13MP0002877_abnormal_melanocyte_morpholog2.55747816
14MP0003252_abnormal_bile_duct2.48603453
15MP0004859_abnormal_synaptic_plasticity2.45634424
16MP0000015_abnormal_ear_pigmentation2.42301791
17MP0004130_abnormal_muscle_cell2.39468875
18MP0003828_pulmonary_edema2.35838989
19MP0008961_abnormal_basal_metabolism2.31272354
20MP0005365_abnormal_bile_salt2.29904246
21MP0003303_peritoneal_inflammation2.27564421
22MP0005075_abnormal_melanosome_morpholog2.19632347
23MP0002909_abnormal_adrenal_gland2.19130650
24MP0008057_abnormal_DNA_replication2.16991708
25MP0000372_irregular_coat_pigmentation2.05629388
26MP0003045_fibrosis2.01975274
27MP0006082_CNS_inflammation1.97499662
28MP0005085_abnormal_gallbladder_physiolo1.94804421
29MP0001835_abnormal_antigen_presentation1.93196405
30MP0008875_abnormal_xenobiotic_pharmacok1.81686798
31MP0003172_abnormal_lysosome_physiology1.81130850
32MP0002419_abnormal_innate_immunity1.80375032
33MP0010329_abnormal_lipoprotein_level1.77711910
34MP0005167_abnormal_blood-brain_barrier1.76406024
35MP0003136_yellow_coat_color1.76384618
36MP0000013_abnormal_adipose_tissue1.72481203
37MP0005076_abnormal_cell_differentiation1.69472678
38MP0004185_abnormal_adipocyte_glucose1.68512594
39MP0005310_abnormal_salivary_gland1.64599930
40MP0000371_diluted_coat_color1.58051356
41MP0010352_gastrointestinal_tract_polyps1.57180596
42MP0008004_abnormal_stomach_pH1.57142275
43MP0003566_abnormal_cell_adhesion1.56027539
44MP0001790_abnormal_immune_system1.53136696
45MP0005387_immune_system_phenotype1.53136696
46MP0005409_darkened_coat_color1.51871673
47MP0000604_amyloidosis1.51245569
48MP0003436_decreased_susceptibility_to1.50139077
49MP0004381_abnormal_hair_follicle1.46142718
50MP0005058_abnormal_lysosome_morphology1.44328981
51MP0005187_abnormal_penis_morphology1.42505703
52MP0003880_abnormal_central_pattern1.40501876
53MP0003656_abnormal_erythrocyte_physiolo1.37770029
54MP0005666_abnormal_adipose_tissue1.35295274
55MP0000003_abnormal_adipose_tissue1.35128814
56MP0000685_abnormal_immune_system1.33366178
57MP0003091_abnormal_cell_migration1.31131974
58MP0008260_abnormal_autophagy1.30780680
59MP0001800_abnormal_humoral_immune1.29384646
60MP0005375_adipose_tissue_phenotype1.28363463
61MP0004510_myositis1.27711937
62MP0002166_altered_tumor_susceptibility1.26633444
63MP0001984_abnormal_olfaction1.26455626
64MP0001440_abnormal_grooming_behavior1.26139532
65MP0000609_abnormal_liver_physiology1.24993354
66MP0004883_abnormal_blood_vessel1.24754499
67MP0005083_abnormal_biliary_tract1.21817105
68MP0002452_abnormal_antigen_presenting1.21658985
69MP0001666_abnormal_nutrient_absorption1.20739311
70MP0003868_abnormal_feces_composition1.20236870
71MP0003646_muscle_fatigue1.18733921
72MP0003329_amyloid_beta_deposits1.17048085
73MP0009115_abnormal_fat_cell1.16981974
74MP0000383_abnormal_hair_follicle1.16928504
75MP0003191_abnormal_cellular_cholesterol1.16363324
76MP0000747_muscle_weakness1.13793725
77* MP0002118_abnormal_lipid_homeostasis1.13646802
78MP0002133_abnormal_respiratory_system1.13447115
79MP0005388_respiratory_system_phenotype1.13447115
80MP0004858_abnormal_nervous_system1.12980468
81MP0002277_abnormal_respiratory_mucosa1.12964933
82MP0005408_hypopigmentation1.11005294
83MP0003075_altered_response_to1.09025947
84MP0002876_abnormal_thyroid_physiology1.08674999
85MP0001485_abnormal_pinna_reflex1.08290940
86MP0002138_abnormal_hepatobiliary_system1.06701063
87MP0002928_abnormal_bile_duct1.06304971
88MP0006054_spinal_hemorrhage1.04659956
89MP0005000_abnormal_immune_tolerance1.03901833
90MP0009840_abnormal_foam_cell1.03603005
91MP0001299_abnormal_eye_distance/1.03169577
92MP0002723_abnormal_immune_serum1.03166336
93MP0002095_abnormal_skin_pigmentation1.03164940
94MP0002971_abnormal_brown_adipose1.03079800
95MP0002332_abnormal_exercise_endurance1.01661337
96MP0002998_abnormal_bone_remodeling1.01480298
97MP0001177_atelectasis1.00853236
98MP0010368_abnormal_lymphatic_system1.00710686
99MP0004947_skin_inflammation1.00430471
100MP0002148_abnormal_hypersensitivity_rea1.00412885
101MP0000920_abnormal_myelination1.00157069
102MP0001533_abnormal_skeleton_physiology0.98215966
103MP0003635_abnormal_synaptic_transmissio0.97923750
104MP0004270_analgesia0.97866128
105MP0002420_abnormal_adaptive_immunity0.97402338
106MP0002078_abnormal_glucose_homeostasis0.97254069
107MP0004036_abnormal_muscle_relaxation0.97053231
108MP0002896_abnormal_bone_mineralization0.96943986
109MP0001819_abnormal_immune_cell0.96708378
110MP0001486_abnormal_startle_reflex0.96366224
111MP0005397_hematopoietic_system_phenotyp0.95555640
112MP0001545_abnormal_hematopoietic_system0.95555640
113MP0009046_muscle_twitch0.95487978
114MP0004264_abnormal_extraembryonic_tissu0.95116661
115MP0001324_abnormal_eye_pigmentation0.95059502
116MP0000427_abnormal_hair_cycle0.94473222
117MP0004087_abnormal_muscle_fiber0.93991902
118MP0002254_reproductive_system_inflammat0.93949020
119MP0003690_abnormal_glial_cell0.93527964
120MP0004084_abnormal_cardiac_muscle0.92736969
121MP0001849_ear_inflammation0.92569048
122MP0005535_abnormal_body_temperature0.91897513
123MP0001765_abnormal_ion_homeostasis0.91711737
124MP0002837_dystrophic_cardiac_calcinosis0.91392052
125MP0002168_other_aberrant_phenotype0.91087059
126MP0005025_abnormal_response_to0.91083148
127MP0003011_delayed_dark_adaptation0.89717941
128MP0004145_abnormal_muscle_electrophysio0.89606083
129MP0003183_abnormal_peptide_metabolism0.89510790
130MP0003633_abnormal_nervous_system0.89262693
131MP0010307_abnormal_tumor_latency0.89154149
132MP0005332_abnormal_amino_acid0.88903840
133MP0005171_absent_coat_pigmentation0.88780864
134MP0005164_abnormal_response_to0.86839897
135MP0005166_decreased_susceptibility_to0.86651694
136MP0005647_abnormal_sex_gland0.83634902
137MP0002090_abnormal_vision0.83427853
138MP0003283_abnormal_digestive_organ0.83315431
139MP0003632_abnormal_nervous_system0.82760506
140MP0001944_abnormal_pancreas_morphology0.82751271
141MP0003453_abnormal_keratinocyte_physiol0.81801614
142MP0005377_hearing/vestibular/ear_phenot0.81735095
143MP0003878_abnormal_ear_physiology0.81735095
144MP0002229_neurodegeneration0.81599210
145MP0002269_muscular_atrophy0.80493313
146MP0004484_altered_response_of0.79282963
147MP0003631_nervous_system_phenotype0.77374699
148MP0009785_altered_susceptibility_to0.77244580
149MP0005275_abnormal_skin_tensile0.76826189
150MP0002693_abnormal_pancreas_physiology0.76794799
151MP0005334_abnormal_fat_pad0.76512874
152MP0000465_gastrointestinal_hemorrhage0.76258013
153MP0000751_myopathy0.75894465
154MP0008874_decreased_physiological_sensi0.75740669
155MP0002009_preneoplasia0.75738064
156MP0000733_abnormal_muscle_development0.75182061
157MP0010678_abnormal_skin_adnexa0.74149651
158MP0001851_eye_inflammation0.74124460
159MP0001845_abnormal_inflammatory_respons0.73614086
160MP0004885_abnormal_endolymph0.73340538
161MP0010630_abnormal_cardiac_muscle0.73217374
162MP0001756_abnormal_urination0.73183720
163MP0001501_abnormal_sleep_pattern0.72226231
164MP0002006_tumorigenesis0.71981793
165MP0008569_lethality_at_weaning0.71505824
166MP0005319_abnormal_enzyme/_coenzyme0.70884225
167MP0004043_abnormal_pH_regulation0.70578498
168MP0009643_abnormal_urine_homeostasis0.70299571
169MP0008438_abnormal_cutaneous_collagen0.69843966
170MP0001958_emphysema0.66661903
171MP0005248_abnormal_Harderian_gland0.66558937
172MP0005464_abnormal_platelet_physiology0.63577162

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.71324473
2Recurrent bacterial skin infections (HP:0005406)3.55347783
3Disinhibition (HP:0000734)3.45631499
4Retrobulbar optic neuritis (HP:0100654)3.31757209
5Optic neuritis (HP:0100653)3.31757209
6Degeneration of the lateral corticospinal tracts (HP:0002314)3.21009718
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.21009718
8Abnormality of macrophages (HP:0004311)3.20776595
9Recurrent abscess formation (HP:0002722)3.09778345
10Cerebral aneurysm (HP:0004944)3.05948591
11Recurrent gram-negative bacterial infections (HP:0005420)2.99404017
12Amyotrophic lateral sclerosis (HP:0007354)2.96384574
13Inappropriate behavior (HP:0000719)2.88438863
14Orchitis (HP:0100796)2.82206799
15Thyroid carcinoma (HP:0002890)2.77637370
16Deep venous thrombosis (HP:0002625)2.68014141
17Abnormality of the corticospinal tract (HP:0002492)2.67302212
18Agnosia (HP:0010524)2.63593129
19Macroorchidism (HP:0000053)2.59527211
20Hyporeflexia of lower limbs (HP:0002600)2.58936451
21Stomatitis (HP:0010280)2.56393663
22Myocardial infarction (HP:0001658)2.55194975
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.53135128
24Abnormality of glycolipid metabolism (HP:0010969)2.49878196
25Abnormality of liposaccharide metabolism (HP:0010968)2.49878196
26Abnormality of glycosphingolipid metabolism (HP:0004343)2.49878196
27Myositis (HP:0100614)2.47761810
28Keratoconjunctivitis (HP:0001096)2.45294735
29Keratoconjunctivitis sicca (HP:0001097)2.44881734
30Absent/shortened dynein arms (HP:0200106)2.43556965
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.43556965
32Abnormal pancreas size (HP:0012094)2.40307193
33Hematochezia (HP:0002573)2.36595231
34Aneurysm (HP:0002617)2.35962160
35Enlarged penis (HP:0000040)2.35088872
36Long toe (HP:0010511)2.34337006
37Febrile seizures (HP:0002373)2.31692727
38Increased CSF protein (HP:0002922)2.30596237
39Action tremor (HP:0002345)2.29245529
40Global brain atrophy (HP:0002283)2.29079693
41Recurrent skin infections (HP:0001581)2.28534902
42Volvulus (HP:0002580)2.28463052
43Mutism (HP:0002300)2.28094312
44Striae distensae (HP:0001065)2.27295595
45Impaired vibration sensation in the lower limbs (HP:0002166)2.27159836
46Papilledema (HP:0001085)2.24914115
47Aortic aneurysm (HP:0004942)2.24808240
48Blue irides (HP:0000635)2.24214739
49Abnormality of the fovea (HP:0000493)2.23832609
50Congenital sensorineural hearing impairment (HP:0008527)2.20717939
51Chronic mucocutaneous candidiasis (HP:0002728)2.20156402
52Recurrent cutaneous fungal infections (HP:0011370)2.20156402
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19972637
54Frequent falls (HP:0002359)2.19808579
55Absent frontal sinuses (HP:0002688)2.19089349
56Dysmetric saccades (HP:0000641)2.18782789
57Iris hypopigmentation (HP:0007730)2.18439692
58Excessive salivation (HP:0003781)2.16453672
59Albinism (HP:0001022)2.16184432
60T lymphocytopenia (HP:0005403)2.15191955
61Neoplasm of the tracheobronchial system (HP:0100552)2.14117175
62Visual hallucinations (HP:0002367)2.13636063
63Ocular albinism (HP:0001107)2.13371640
64Osteomalacia (HP:0002749)2.12995824
65Generalized hypopigmentation (HP:0007513)2.11780622
66Gaze-evoked nystagmus (HP:0000640)2.11646392
67Mitral valve prolapse (HP:0001634)2.11360448
68Hyperkalemia (HP:0002153)2.11020622
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.10983581
70Hypoplasia of the fovea (HP:0007750)2.10983581
71Xanthomatosis (HP:0000991)2.10378730
72Drooling (HP:0002307)2.09665071
73Abnormality of the common coagulation pathway (HP:0010990)2.08519159
74Upper limb amyotrophy (HP:0009129)2.06358503
75Distal upper limb amyotrophy (HP:0007149)2.06358503
76Abnormal hair whorl (HP:0010721)2.04966099
77Polycythemia (HP:0001901)2.04564522
78Subacute progressive viral hepatitis (HP:0006572)2.00649889
79Heterotopia (HP:0002282)1.99952238
80Abnormality of the Achilles tendon (HP:0005109)1.99926442
81Abnormality of T cell number (HP:0011839)1.98413437
82Difficulty running (HP:0009046)1.98097887
83Hyperglycemia (HP:0003074)1.97853518
84Postural instability (HP:0002172)1.97351761
85Mediastinal lymphadenopathy (HP:0100721)1.96939752
86Abnormal respiratory motile cilium morphology (HP:0005938)1.96272129
87Abnormal respiratory epithelium morphology (HP:0012253)1.96272129
88Protruding tongue (HP:0010808)1.96025877
89Hemiplegia (HP:0002301)1.95374290
90Goiter (HP:0000853)1.94627698
91Arterial tortuosity (HP:0005116)1.91876685
92Hypoalphalipoproteinemia (HP:0003233)1.91704103
93Alveolar cell carcinoma (HP:0006519)1.90795795
94Achilles tendon contracture (HP:0001771)1.89597103
95Esophageal varix (HP:0002040)1.88992481
96Hand muscle atrophy (HP:0009130)1.88133488
97Resting tremor (HP:0002322)1.88082678
98Hyperventilation (HP:0002883)1.87172471
99Abnormal ciliary motility (HP:0012262)1.87171826
100Complement deficiency (HP:0004431)1.87017759
101Chronic bronchitis (HP:0004469)1.86949831
102Hypoglycemic coma (HP:0001325)1.86679167
103Generalized hypopigmentation of hair (HP:0011358)1.86241922
104Lower limb muscle weakness (HP:0007340)1.85944642
105Gingivitis (HP:0000230)1.85622645
106Mucopolysacchariduria (HP:0008155)1.84767339
107Urinary glycosaminoglycan excretion (HP:0003541)1.84767339
108Supranuclear gaze palsy (HP:0000605)1.84752544
109Truncal obesity (HP:0001956)1.84745098
110Recurrent fungal infections (HP:0002841)1.84123803
111Skin nodule (HP:0200036)1.83660369
112Abnormal delayed hypersensitivity skin test (HP:0002963)1.83541641
113Progressive cerebellar ataxia (HP:0002073)1.83182869
114Gonadotropin excess (HP:0000837)1.83075919
115Widely spaced teeth (HP:0000687)1.83064660
116Sensorimotor neuropathy (HP:0007141)1.82893826
117White forelock (HP:0002211)1.82849543
118Genetic anticipation (HP:0003743)1.81366445
119Rhinitis (HP:0012384)1.81069724
120Polyphagia (HP:0002591)1.80823286
121Neurofibrillary tangles (HP:0002185)1.80283384
122Abnormality of the lower motor neuron (HP:0002366)1.79923607
123Hyperinsulinemic hypoglycemia (HP:0000825)1.79515275
124Aplasia/Hypoplasia of the macula (HP:0008059)1.79150547
125Impaired vibratory sensation (HP:0002495)1.78884015
126Hypoglycemic seizures (HP:0002173)1.78122738
127Abnormal respiratory motile cilium physiology (HP:0012261)1.78105546
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77491351
129Abnormality of polysaccharide metabolism (HP:0011012)1.77491351
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77491351
131Lymphangioma (HP:0100764)1.77469515
132Asplenia (HP:0001746)1.76222270
133Mitral stenosis (HP:0001718)1.75612029
134Loss of speech (HP:0002371)1.75054888
135Bronchiectasis (HP:0002110)1.74903293
136Vascular tortuosity (HP:0004948)1.73256503
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.72616807
138Ketoacidosis (HP:0001993)1.72174052
139Focal seizures (HP:0007359)1.72139546
140Abnormality of the periventricular white matter (HP:0002518)1.71960956
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71703122
142Vacuolated lymphocytes (HP:0001922)1.71027914
143Bundle branch block (HP:0011710)1.70815976
144Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70788827
145Asymmetric septal hypertrophy (HP:0001670)1.69924273
146Pulmonary infiltrates (HP:0002113)1.69622548
147Recurrent sinusitis (HP:0011108)1.68619362
148Intrahepatic cholestasis (HP:0001406)1.68469641
149Insulin-resistant diabetes mellitus (HP:0000831)1.68453220
150Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.67662206
151Milia (HP:0001056)1.67514881
152Exercise-induced muscle cramps (HP:0003710)1.67288555
153Narrow palate (HP:0000189)1.67081695
154Epidermoid cyst (HP:0200040)1.67034452
155Turricephaly (HP:0000262)1.66230727
156Exercise-induced myalgia (HP:0003738)1.65801667
157Termporal pattern (HP:0011008)1.65251426
158Insidious onset (HP:0003587)1.65251426
159Increased cerebral lipofuscin (HP:0011813)1.63099596
160EMG: neuropathic changes (HP:0003445)1.62381790
161Cerebral inclusion bodies (HP:0100314)1.60585525
162Dilatation of the ascending aorta (HP:0005111)1.58129293
163Rectal prolapse (HP:0002035)1.57790694
164Ventricular fibrillation (HP:0001663)1.57246983
165Papillary thyroid carcinoma (HP:0002895)1.56704759
166Hyperacusis (HP:0010780)1.56087697
167Increased connective tissue (HP:0009025)1.55144593
168Dysostosis multiplex (HP:0000943)1.54279935
169Urinary bladder sphincter dysfunction (HP:0002839)1.54093468
170Elfin facies (HP:0004428)1.52827933
171Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.50858515
172Thin bony cortex (HP:0002753)1.50713252
173Abnormality of monocarboxylic acid metabolism (HP:0010996)1.50020324
174Status epilepticus (HP:0002133)1.49935647
175Abnormality of the fingertips (HP:0001211)1.49787931
176Ketosis (HP:0001946)1.49674402
177Neuronal loss in central nervous system (HP:0002529)1.49379885
178Neoplasm of the heart (HP:0100544)1.49321431
179Gout (HP:0001997)1.48729714
180Lower limb amyotrophy (HP:0007210)1.48582011
181Intention tremor (HP:0002080)1.48494068
182Osteolytic defects of the hand bones (HP:0009699)1.48171415
183Osteolytic defects of the phalanges of the hand (HP:0009771)1.48171415
184Coarse hair (HP:0002208)1.47946829
185Urinary urgency (HP:0000012)1.47685913
186Male infertility (HP:0003251)1.47390358
187Focal segmental glomerulosclerosis (HP:0000097)1.47024372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.55141639
2TRIB33.12122410
3RIPK12.62183382
4LATS12.58921113
5TNIK2.28484965
6MAP3K92.22478777
7MAP3K22.22353582
8PKN22.20703088
9KSR22.18576561
10PNCK1.90499979
11STK241.90341021
12CAMK1G1.87003704
13CAMK1D1.86491106
14ERN11.85381028
15TAOK31.84512506
16PRKD31.82836363
17CDK121.82753730
18FRK1.82566073
19YES11.72454543
20AKT31.71674994
21PTK61.64343706
22STK381.58006030
23RET1.56673717
24CAMKK11.54877464
25TTN1.53807886
26FGR1.52625413
27PDGFRA1.51735219
28CDK191.51433511
29PIK3CG1.51254584
30SIK11.51167978
31NTRK31.50550485
32PAK61.44500490
33TAOK11.43609074
34BLK1.43384271
35INSRR1.37905854
36LATS21.37555212
37SIK21.35173001
38BCR1.35160492
39MAP2K41.31844268
40SCYL21.31722313
41MAP3K71.31306265
42MAP3K41.30949679
43NTRK11.30315370
44TRIM281.26104820
45NLK1.25819604
46LMTK21.24484359
47JAK11.24350793
48DMPK1.24332522
49FGFR31.23887901
50PLK21.23622906
51PRKCH1.23338868
52RIPK41.21327840
53MAP3K141.20769364
54BRD41.20267643
55KSR11.17780755
56MAP3K131.17175297
57ERBB31.15377657
58PDGFRB1.12428386
59SGK31.10204859
60STK38L1.09684919
61SGK4941.07069597
62SGK2231.07069597
63MAP3K11.03404952
64PTK21.03222293
65WNK11.02485472
66MKNK21.02211028
67CDK61.02083217
68HIPK20.99496136
69OXSR10.98468029
70MATK0.97907087
71WNK30.97324422
72SIK30.95770150
73IRAK40.94280568
74BMPR20.92852981
75BMPR1B0.90634017
76PDPK10.89573448
77PDK10.88705913
78JAK20.87604106
79IRAK10.86041894
80STK30.85919477
81TGFBR20.84004592
82EPHB10.83731331
83FER0.83681196
84DAPK20.83626380
85FGFR40.82847167
86ALK0.81103011
87PAK30.79212194
88MAP3K100.78751530
89LRRK20.78423486
90DYRK1A0.72612506
91BMX0.72607051
92CSF1R0.70058037
93EEF2K0.70008312
94NEK10.69937163
95MAP3K60.69884591
96CAMKK20.69662135
97TYRO30.69036876
98TEC0.68976914
99MARK20.68285485
100STK100.67155043
101MTOR0.67022931
102CAMK10.65238069
103TAF10.65204580
104SGK20.63930900
105STK110.63617174
106PRKAA10.63569162
107IKBKE0.62613632
108FES0.61645516
109FGFR20.61498685
110MINK10.60680852
111MARK30.58631317
112MAPK70.57855385
113SYK0.57293914
114PRKAA20.57211298
115PRKCQ0.57008136
116SGK10.54441736
117PTK2B0.53833556
118PRPF4B0.53228741
119PINK10.53034228
120JAK30.52550365
121MAP2K10.51841708
122DYRK30.50787646
123* PRKD10.50362912
124PDK30.50104515
125PDK40.50104515
126HCK0.49742656
127ABL10.49740028
128MAPK100.49608990
129MELK0.48850935
130LYN0.48735997
131EGFR0.48490373
132NEK90.48226100
133CASK0.48221698
134RAF10.47784551
135CDC42BPA0.47541355
136TYK20.47070303
137PRKD20.46997077
138PRKCE0.46242300
139MKNK10.45209765
140KIT0.44837746
141NEK60.44267078
142CDK50.43257966
143MUSK0.42843704
144MAP3K30.42819134
145RPS6KA30.42207126
146EPHA40.42098024
147CSK0.41727617
148MAPK120.41431313
149RPS6KA20.41209767
150MAP3K50.38705252
151TRPM70.35937871

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.25980384
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74696901
3Leishmaniasis_Homo sapiens_hsa051401.65029313
4Lysosome_Homo sapiens_hsa041421.63567811
5Tuberculosis_Homo sapiens_hsa051521.58174161
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58104494
7Arginine biosynthesis_Homo sapiens_hsa002201.52386469
8Type II diabetes mellitus_Homo sapiens_hsa049301.51027298
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47816681
10Autoimmune thyroid disease_Homo sapiens_hsa053201.44398404
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41884096
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38726005
13Bile secretion_Homo sapiens_hsa049761.36293929
14Legionellosis_Homo sapiens_hsa051341.33074788
15Dorso-ventral axis formation_Homo sapiens_hsa043201.30777091
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28921135
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27575399
18Type I diabetes mellitus_Homo sapiens_hsa049401.25895440
19Phagosome_Homo sapiens_hsa041451.25025987
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24532720
21Graft-versus-host disease_Homo sapiens_hsa053321.22678266
22mTOR signaling pathway_Homo sapiens_hsa041501.21849876
23Insulin resistance_Homo sapiens_hsa049311.18097556
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17159890
25Asthma_Homo sapiens_hsa053101.16633695
26Long-term potentiation_Homo sapiens_hsa047201.16072561
27Regulation of autophagy_Homo sapiens_hsa041401.14866439
28Insulin secretion_Homo sapiens_hsa049111.14690627
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13239206
30Chemokine signaling pathway_Homo sapiens_hsa040621.11213998
31Gastric acid secretion_Homo sapiens_hsa049711.10303543
32Allograft rejection_Homo sapiens_hsa053301.09515574
33Nicotine addiction_Homo sapiens_hsa050331.06292162
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06175592
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04517998
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04451896
37Sphingolipid signaling pathway_Homo sapiens_hsa040711.03933001
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03656892
39Collecting duct acid secretion_Homo sapiens_hsa049661.03307830
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.02940006
41Caffeine metabolism_Homo sapiens_hsa002321.00859718
42Glioma_Homo sapiens_hsa052140.98839065
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98656240
44Renin secretion_Homo sapiens_hsa049240.98206627
45Estrogen signaling pathway_Homo sapiens_hsa049150.97986995
46Lysine degradation_Homo sapiens_hsa003100.97487386
47Glucagon signaling pathway_Homo sapiens_hsa049220.97418187
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.96245192
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95042756
50Salivary secretion_Homo sapiens_hsa049700.94976903
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.93678336
52GnRH signaling pathway_Homo sapiens_hsa049120.92566322
53Synaptic vesicle cycle_Homo sapiens_hsa047210.91705565
54VEGF signaling pathway_Homo sapiens_hsa043700.90045046
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89456379
56Rheumatoid arthritis_Homo sapiens_hsa053230.89265099
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87986590
58Complement and coagulation cascades_Homo sapiens_hsa046100.86454373
59Chronic myeloid leukemia_Homo sapiens_hsa052200.86009687
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85366158
61Fatty acid degradation_Homo sapiens_hsa000710.85214126
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85205692
63Circadian entrainment_Homo sapiens_hsa047130.84608162
64Insulin signaling pathway_Homo sapiens_hsa049100.83914479
65Oxytocin signaling pathway_Homo sapiens_hsa049210.83375516
66Sphingolipid metabolism_Homo sapiens_hsa006000.82605415
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.82168330
68ABC transporters_Homo sapiens_hsa020100.82083933
69PPAR signaling pathway_Homo sapiens_hsa033200.81634336
70T cell receptor signaling pathway_Homo sapiens_hsa046600.81294133
71Cholinergic synapse_Homo sapiens_hsa047250.80826816
72Olfactory transduction_Homo sapiens_hsa047400.80337806
73Amphetamine addiction_Homo sapiens_hsa050310.79200906
74Thyroid hormone synthesis_Homo sapiens_hsa049180.78751602
75Malaria_Homo sapiens_hsa051440.77791663
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77254232
77cAMP signaling pathway_Homo sapiens_hsa040240.77235559
78Adherens junction_Homo sapiens_hsa045200.76798983
79Prolactin signaling pathway_Homo sapiens_hsa049170.76639859
80Acute myeloid leukemia_Homo sapiens_hsa052210.76424967
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76240516
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76081040
83Dopaminergic synapse_Homo sapiens_hsa047280.75112149
84Amoebiasis_Homo sapiens_hsa051460.74318329
85Pancreatic secretion_Homo sapiens_hsa049720.73935903
86Glycerolipid metabolism_Homo sapiens_hsa005610.73862433
87GABAergic synapse_Homo sapiens_hsa047270.73757369
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73472517
89Pancreatic cancer_Homo sapiens_hsa052120.73169383
90Osteoclast differentiation_Homo sapiens_hsa043800.72531206
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72434545
92Non-small cell lung cancer_Homo sapiens_hsa052230.71736351
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71704536
94Focal adhesion_Homo sapiens_hsa045100.71651479
95Hepatitis C_Homo sapiens_hsa051600.71517811
96Proteoglycans in cancer_Homo sapiens_hsa052050.71127152
97Endometrial cancer_Homo sapiens_hsa052130.70616004
98Platelet activation_Homo sapiens_hsa046110.70291246
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.69890734
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.69356609
101Choline metabolism in cancer_Homo sapiens_hsa052310.68764381
102Fatty acid biosynthesis_Homo sapiens_hsa000610.67733929
103AMPK signaling pathway_Homo sapiens_hsa041520.67549312
104Glutamatergic synapse_Homo sapiens_hsa047240.66740895
105Inositol phosphate metabolism_Homo sapiens_hsa005620.65772696
106Renal cell carcinoma_Homo sapiens_hsa052110.65744545
107Influenza A_Homo sapiens_hsa051640.65352009
108Dilated cardiomyopathy_Homo sapiens_hsa054140.65059155
109Prostate cancer_Homo sapiens_hsa052150.64937068
110Staphylococcus aureus infection_Homo sapiens_hsa051500.64536974
111Circadian rhythm_Homo sapiens_hsa047100.64089375
112Rap1 signaling pathway_Homo sapiens_hsa040150.63314829
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.63227525
114Tryptophan metabolism_Homo sapiens_hsa003800.62826018
115B cell receptor signaling pathway_Homo sapiens_hsa046620.62515201
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61985380
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61618818
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61418307
119Starch and sucrose metabolism_Homo sapiens_hsa005000.61028147
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.60778550
121Ether lipid metabolism_Homo sapiens_hsa005650.59933519
122ErbB signaling pathway_Homo sapiens_hsa040120.59397146
123Cocaine addiction_Homo sapiens_hsa050300.59179772
124Measles_Homo sapiens_hsa051620.59054564
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57563902
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57155374
127Toxoplasmosis_Homo sapiens_hsa051450.57017405
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56843088
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.56809028
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55713038
131Hematopoietic cell lineage_Homo sapiens_hsa046400.55709398
132Endocytosis_Homo sapiens_hsa041440.55426395
133Morphine addiction_Homo sapiens_hsa050320.55215522
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55142140
135Serotonergic synapse_Homo sapiens_hsa047260.54716856
136Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54460063
137Histidine metabolism_Homo sapiens_hsa003400.54142827
138FoxO signaling pathway_Homo sapiens_hsa040680.53454450
139Long-term depression_Homo sapiens_hsa047300.53379456
140TNF signaling pathway_Homo sapiens_hsa046680.52965735
141Calcium signaling pathway_Homo sapiens_hsa040200.52942174
142MAPK signaling pathway_Homo sapiens_hsa040100.52701083
143beta-Alanine metabolism_Homo sapiens_hsa004100.52590870
144Ras signaling pathway_Homo sapiens_hsa040140.52590619
145Gap junction_Homo sapiens_hsa045400.52467412
146Antigen processing and presentation_Homo sapiens_hsa046120.52361820
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.51974730

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