COL4A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerulus development (GO:0032835)8.35071345
2skeletal muscle adaptation (GO:0043501)7.40022070
3mesenchymal-epithelial cell signaling (GO:0060638)6.13277308
4surfactant homeostasis (GO:0043129)6.13031048
5peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.96707888
6drug transmembrane transport (GO:0006855)5.68066002
7regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.58907762
8excretion (GO:0007588)5.33287223
9camera-type eye morphogenesis (GO:0048593)5.31470720
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr5.23203743
11epithelial cell differentiation involved in kidney development (GO:0035850)5.17418788
12otic vesicle formation (GO:0030916)5.03467429
13urate metabolic process (GO:0046415)4.85595904
14radial glial cell differentiation (GO:0060019)4.85068020
15metanephric epithelium development (GO:0072207)4.76435382
16chemical homeostasis within a tissue (GO:0048875)4.72156671
17aminoglycoside antibiotic metabolic process (GO:0030647)4.70520162
18negative regulation of stress fiber assembly (GO:0051497)4.67058882
19lateral sprouting from an epithelium (GO:0060601)4.59110887
20muscle cell fate commitment (GO:0042693)4.53467389
21keratan sulfate catabolic process (GO:0042340)4.48260178
22regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.47766031
23phosphate ion transport (GO:0006817)4.46099396
24drug transport (GO:0015893)4.44168371
25positive regulation of male gonad development (GO:2000020)4.40173892
26negative regulation of Rho protein signal transduction (GO:0035024)4.38688005
27embryonic camera-type eye development (GO:0031076)4.36521403
28vascular endothelial growth factor signaling pathway (GO:0038084)4.28561082
29striated muscle hypertrophy (GO:0014897)4.16493443
30positive regulation of p38MAPK cascade (GO:1900745)4.10902847
31lysine metabolic process (GO:0006553)4.09796379
32lysine catabolic process (GO:0006554)4.09796379
33protein localization to cell surface (GO:0034394)4.01837859
34peripheral nervous system axon ensheathment (GO:0032292)4.00135410
35myelination in peripheral nervous system (GO:0022011)4.00135410
36endothelial cell chemotaxis (GO:0035767)3.96909652
37renal filtration (GO:0097205)3.96456153
38organic cation transport (GO:0015695)3.91869193
39response to mercury ion (GO:0046689)3.89279739
40muscle hypertrophy (GO:0014896)3.81879611
41metanephric tubule development (GO:0072170)3.77884102
42metanephric nephron tubule development (GO:0072234)3.77884102
43regulation of male gonad development (GO:2000018)3.77581819
44striated muscle adaptation (GO:0014888)3.77183562
45lung epithelium development (GO:0060428)3.74722524
46myoblast fusion (GO:0007520)3.74337728
47phosphate ion transmembrane transport (GO:0035435)3.73243890
48metanephric nephron epithelium development (GO:0072243)3.70240126
49coronary vasculature morphogenesis (GO:0060977)3.70001687
50renal absorption (GO:0070293)3.69711418
51regulation of glomerular filtration (GO:0003093)3.65254483
52lung vasculature development (GO:0060426)3.62624060
53cell adhesion mediated by integrin (GO:0033627)3.62391772
54kidney mesenchyme development (GO:0072074)3.61782256
55renal system process involved in regulation of blood volume (GO:0001977)3.56447997
56metanephric mesenchyme development (GO:0072075)3.56433481
57organ growth (GO:0035265)3.54983847
58myofibril assembly (GO:0030239)3.54166813
59cell migration involved in heart development (GO:0060973)3.52311232
60muscle filament sliding (GO:0030049)3.51342653
61actin-myosin filament sliding (GO:0033275)3.51342653
62regulation of axon guidance (GO:1902667)3.49122043
63quaternary ammonium group transport (GO:0015697)3.48958879
64negative regulation of actin filament bundle assembly (GO:0032232)3.48712105
65regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.48165601
66genitalia morphogenesis (GO:0035112)3.46293133
67lymphangiogenesis (GO:0001946)3.45434488
68induction of positive chemotaxis (GO:0050930)3.45381513
69diaphragm development (GO:0060539)3.44048314
70negative regulation of metanephros development (GO:0072217)3.40516052
71cell migration involved in sprouting angiogenesis (GO:0002042)3.37600670
72gonadal mesoderm development (GO:0007506)3.37155103
73positive regulation of cell junction assembly (GO:1901890)3.37079149
74positive regulation of focal adhesion assembly (GO:0051894)3.37079149
75sex determination (GO:0007530)3.36501991
76activation of Rac GTPase activity (GO:0032863)3.35874283
77syncytium formation by plasma membrane fusion (GO:0000768)3.33033413
78positive regulation of adherens junction organization (GO:1903393)3.30505676
79bicarbonate transport (GO:0015701)3.30099339
80regulation of p38MAPK cascade (GO:1900744)3.29624961
81negative regulation of axon guidance (GO:1902668)3.28999305
82venous blood vessel morphogenesis (GO:0048845)3.25150990
83angiotensin maturation (GO:0002003)3.23101472
84lymph vessel development (GO:0001945)3.21603813
85wound healing, spreading of epidermal cells (GO:0035313)3.21405558
86cardiac myofibril assembly (GO:0055003)3.20693180
87eye morphogenesis (GO:0048592)3.19931820
88drug catabolic process (GO:0042737)3.19875200
89positive regulation of cell adhesion mediated by integrin (GO:0033630)3.19509903
90exogenous drug catabolic process (GO:0042738)3.15554536
91positive regulation of digestive system process (GO:0060456)3.13949880
92regulation of hippo signaling (GO:0035330)3.12143385
93mesonephros development (GO:0001823)3.12097698
94vitamin D metabolic process (GO:0042359)3.08696592
95cardiac muscle cell proliferation (GO:0060038)3.08174107
96protein localization to endosome (GO:0036010)3.07854017
97actin-mediated cell contraction (GO:0070252)3.05726380
98lung secretory cell differentiation (GO:0061140)3.03726343
99phosphate ion homeostasis (GO:0055062)2.99586757
100trivalent inorganic anion homeostasis (GO:0072506)2.99586757
101apoptotic cell clearance (GO:0043277)2.99210644
102skeletal muscle organ development (GO:0060538)2.98511702
103nephron epithelium development (GO:0072009)2.97936774
104embryonic digestive tract morphogenesis (GO:0048557)2.96392905
105limb bud formation (GO:0060174)2.95975228
106sarcomere organization (GO:0045214)2.95010363
107positive regulation of catenin import into nucleus (GO:0035413)2.94552143
108basement membrane organization (GO:0071711)2.94102650
109positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.93500095
110glomerular filtration (GO:0003094)2.93151980
111* collagen metabolic process (GO:0032963)2.93038283
112regulation of endothelial cell chemotaxis (GO:2001026)2.92205037
113hypotonic response (GO:0006971)2.92096317
114peptidyl-proline hydroxylation (GO:0019511)2.91408031
115pericardium development (GO:0060039)2.91308642
116* collagen catabolic process (GO:0030574)2.91300252
117regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91205415
118cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.90284590
119protein heterotrimerization (GO:0070208)2.89817231
120actin filament-based movement (GO:0030048)2.89501068
121renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.89329290
122nephron tubule development (GO:0072080)2.89014309
123regulation of apoptotic process involved in morphogenesis (GO:1902337)2.88166765
124neuronal ion channel clustering (GO:0045161)2.87905304
125muscle adaptation (GO:0043500)2.87302507
126smooth muscle cell differentiation (GO:0051145)2.85474724
127cellular response to reactive nitrogen species (GO:1902170)2.85211205
128collagen fibril organization (GO:0030199)2.85070541
129dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84868647
130protein hydroxylation (GO:0018126)2.82599887
131cornea development in camera-type eye (GO:0061303)2.82470822
132epithelial cell-cell adhesion (GO:0090136)2.81819759
133peptide catabolic process (GO:0043171)2.81641167
134regulation of axon extension involved in axon guidance (GO:0048841)2.78990806
135glyoxylate metabolic process (GO:0046487)2.78064460
136amino-acid betaine transport (GO:0015838)2.77894873
137carnitine transport (GO:0015879)2.77894873
138cellular response to antibiotic (GO:0071236)2.77302181
139fibroblast migration (GO:0010761)2.77143773
140* multicellular organismal macromolecule metabolic process (GO:0044259)2.76751031
141negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.76243784
142renal system process (GO:0003014)2.75963616
143syncytium formation (GO:0006949)2.75791849
144actomyosin structure organization (GO:0031032)2.75554159
145regulation of glucose import in response to insulin stimulus (GO:2001273)2.75122117
146cell differentiation involved in kidney development (GO:0061005)2.72995741
147retina vasculature morphogenesis in camera-type eye (GO:0061299)2.72757766
148tricarboxylic acid metabolic process (GO:0072350)2.70858596
149negative regulation of complement activation (GO:0045916)2.70551973
150homocysteine metabolic process (GO:0050667)2.69717421
151response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.69066585
152striated muscle cell proliferation (GO:0014855)2.68250332
153* multicellular organismal metabolic process (GO:0044236)2.67992581
154toxin transport (GO:1901998)2.67947475
155sodium-independent organic anion transport (GO:0043252)2.67684843
156vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.66598442
157branching involved in salivary gland morphogenesis (GO:0060445)2.66294292
158* multicellular organismal catabolic process (GO:0044243)2.63823541
159regulation of alkaline phosphatase activity (GO:0010692)2.63695278
160receptor guanylyl cyclase signaling pathway (GO:0007168)2.63059117
161endocytic recycling (GO:0032456)2.62421430
162short-chain fatty acid metabolic process (GO:0046459)2.61556849
163negative regulation of vascular permeability (GO:0043116)2.60636648
164cysteine metabolic process (GO:0006534)2.59960546
165renal tubule development (GO:0061326)2.59055998
166negative regulation of cell-matrix adhesion (GO:0001953)2.58989671
167stress fiber assembly (GO:0043149)2.55636006
168regulation of mitochondrial depolarization (GO:0051900)2.55391163
169glucocorticoid biosynthetic process (GO:0006704)2.55293553
170white fat cell differentiation (GO:0050872)2.55225137
171polyol transport (GO:0015791)2.54369439
172non-canonical Wnt signaling pathway (GO:0035567)2.54296188
173thyroid gland development (GO:0030878)2.53495392
174plasma membrane repair (GO:0001778)2.53314792
175valine metabolic process (GO:0006573)2.52921870
176renal tubule morphogenesis (GO:0061333)2.52119260
177establishment of nucleus localization (GO:0040023)2.52046102
178endothelium development (GO:0003158)2.51325505
179mesenchymal cell differentiation (GO:0048762)2.51290208
180cellular response to vitamin D (GO:0071305)2.50921966
181regulation of relaxation of muscle (GO:1901077)2.50716401
182glomerular visceral epithelial cell development (GO:0072015)14.7914721
183glomerular epithelial cell development (GO:0072310)13.1754889
184* glomerular basement membrane development (GO:0032836)10.5422929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human3.86987878
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.75614812
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02956542
4CLOCK_20551151_ChIP-Seq_293T_Human2.99396133
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78347359
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77068741
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.72461695
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50096451
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33428260
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.29779883
11CTNNB1_20460455_ChIP-Seq_HCT116_Human2.19232523
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.10995002
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10747838
14* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01338076
15HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99893969
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89859379
17GATA2_21666600_ChIP-Seq_HMVEC_Human1.87157816
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.87056007
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.86959623
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84878216
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82345544
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78455038
23WT1_25993318_ChIP-Seq_PODOCYTE_Human1.77597829
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.77331032
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.74558116
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.74289241
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69206805
28* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67284534
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64462904
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63832485
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.63460823
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62154615
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60374385
34AHR_22903824_ChIP-Seq_MCF-7_Human1.59635492
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55516624
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.54746396
37TBX20_22080862_ChIP-Seq_HEART_Mouse1.54644444
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.54644444
39TP53_16413492_ChIP-PET_HCT116_Human1.52650769
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51093107
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.48897362
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47424973
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46822706
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44168974
45SMAD3_21741376_ChIP-Seq_HESCs_Human1.41188109
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.40876765
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.39612612
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.38622695
49CJUN_26792858_Chip-Seq_BT549_Human1.35905271
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.35028335
51PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.33858778
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33377217
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32639042
54GATA4_25053715_ChIP-Seq_YYC3_Human1.29364342
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26293627
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25930850
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25159724
58SOX2_20726797_ChIP-Seq_SW620_Human1.25051800
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24671392
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24615921
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24615921
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.24293853
63KDM2B_26808549_Chip-Seq_K562_Human1.21626963
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19691772
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19622393
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19036334
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.17706366
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15551742
69* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14610583
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13274269
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12578044
72STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09867141
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09664745
74TP53_18474530_ChIP-ChIP_U2OS_Human1.08877774
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08845263
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08633257
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08100342
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07988780
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06786885
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06261598
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05923258
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04812724
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.04119815
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03879513
85SMAD4_21741376_ChIP-Seq_HESCs_Human1.03445538
86* TCF4_18268006_ChIP-ChIP_LS174T_Human1.02845186
87* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02436235
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01925828
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01707855
90RACK7_27058665_Chip-Seq_MCF-7_Human0.99880582
91* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99792099
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99605873
93LXR_22292898_ChIP-Seq_THP-1_Human0.99533880
94EED_16625203_ChIP-ChIP_MESCs_Mouse0.98511563
95AR_21572438_ChIP-Seq_LNCaP_Human0.98461816
96ISL1_27105846_Chip-Seq_CPCs_Mouse0.97979635
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97207779
98DROSHA_22980978_ChIP-Seq_HELA_Human0.96953336
99BRD4_25478319_ChIP-Seq_HGPS_Human0.95775409
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95303276
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95296348
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95241530
103GATA1_22025678_ChIP-Seq_K562_Human0.95123545
104GATA2_19941826_ChIP-Seq_K562_Human0.94765781
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94117699
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92841872
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92223412
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91571184
109UBF1/2_26484160_Chip-Seq_HMECs_Human0.91519123
110FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91478215
111* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91263372
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.90878743
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90133896
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89582593
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89362374
116YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88134137
117TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87520301
118* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86762059
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86484478
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86479983
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86340046
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86340046
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85910934
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85690514
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85474815
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84756292
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84756292
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84562863
129* FLI1_27457419_Chip-Seq_LIVER_Mouse0.84315819
130SMAD4_21799915_ChIP-Seq_A2780_Human0.84110867
131TP63_23658742_ChIP-Seq_EP156T_Human0.83834853
132RXR_22108803_ChIP-Seq_LS180_Human0.83751963
133* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83737427
134* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.83726383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure4.77662497
2MP0004043_abnormal_pH_regulation4.29194187
3MP0004272_abnormal_basement_membrane4.09005275
4MP0001958_emphysema3.69779916
5MP0003195_calcinosis3.57391974
6MP0005360_urolithiasis3.42897549
7MP0009643_abnormal_urine_homeostasis3.29647947
8MP0003878_abnormal_ear_physiology3.27498468
9MP0005377_hearing/vestibular/ear_phenot3.27498468
10MP0005623_abnormal_meninges_morphology3.18826887
11MP0002138_abnormal_hepatobiliary_system2.97230765
12* MP0005332_abnormal_amino_acid2.97182446
13MP0001756_abnormal_urination2.96864802
14MP0010030_abnormal_orbit_morphology2.96634997
15MP0004084_abnormal_cardiac_muscle2.90828946
16MP0010368_abnormal_lymphatic_system2.88795552
17MP0002102_abnormal_ear_morphology2.86159809
18* MP0002136_abnormal_kidney_physiology2.85549906
19MP0001661_extended_life_span2.81485172
20MP0005248_abnormal_Harderian_gland2.73120524
21MP0001879_abnormal_lymphatic_vessel2.54973342
22MP0008995_early_reproductive_senescence2.44615322
23MP0001765_abnormal_ion_homeostasis2.42777590
24MP0004019_abnormal_vitamin_homeostasis2.40329903
25MP0000537_abnormal_urethra_morphology2.11142655
26MP0000230_abnormal_systemic_arterial1.99949193
27MP0004036_abnormal_muscle_relaxation1.96452169
28MP0005167_abnormal_blood-brain_barrier1.90933007
29MP0005503_abnormal_tendon_morphology1.87449164
30MP0003252_abnormal_bile_duct1.86717701
31MP0008961_abnormal_basal_metabolism1.83748569
32MP0000534_abnormal_ureter_morphology1.80945595
33MP0003646_muscle_fatigue1.78925302
34MP0009384_cardiac_valve_regurgitation1.77691667
35* MP0002135_abnormal_kidney_morphology1.76727315
36MP0002139_abnormal_hepatobiliary_system1.75962359
37MP0003300_gastrointestinal_ulcer1.73710918
38MP0002168_other_aberrant_phenotype1.63631990
39MP0003942_abnormal_urinary_system1.61697488
40MP0002877_abnormal_melanocyte_morpholog1.54378139
41MP0003283_abnormal_digestive_organ1.51576622
42MP0005636_abnormal_mineral_homeostasis1.50436791
43MP0005193_abnormal_anterior_eye1.44156492
44MP0004087_abnormal_muscle_fiber1.43966333
45MP0000749_muscle_degeneration1.42863068
46MP0000733_abnormal_muscle_development1.41583743
47MP0002295_abnormal_pulmonary_circulatio1.41368975
48MP0000579_abnormal_nail_morphology1.39615007
49MP0002332_abnormal_exercise_endurance1.35318413
50MP0002132_abnormal_respiratory_system1.35287516
51MP0002909_abnormal_adrenal_gland1.33923443
52MP0006138_congestive_heart_failure1.28639689
53MP0004145_abnormal_muscle_electrophysio1.28555155
54MP0004885_abnormal_endolymph1.24621814
55MP0000759_abnormal_skeletal_muscle1.24342370
56MP0008438_abnormal_cutaneous_collagen1.22205242
57MP0002009_preneoplasia1.22034061
58MP0009250_abnormal_appendicular_skeleto1.20328306
59MP0003941_abnormal_skin_development1.19825557
60MP0002269_muscular_atrophy1.16802088
61MP0003566_abnormal_cell_adhesion1.16316557
62MP0003115_abnormal_respiratory_system1.14884118
63MP0000678_abnormal_parathyroid_gland1.14523613
64MP0005369_muscle_phenotype1.11147624
65MP0000566_synostosis1.07728490
66MP0003045_fibrosis1.05015830
67MP0002896_abnormal_bone_mineralization1.04874220
68MP0003091_abnormal_cell_migration1.04618703
69MP0008004_abnormal_stomach_pH1.03443224
70MP0009780_abnormal_chondrocyte_physiolo0.99299631
71MP0003705_abnormal_hypodermis_morpholog0.99019215
72MP0004484_altered_response_of0.98751948
73MP0004233_abnormal_muscle_weight0.97509896
74MP0005058_abnormal_lysosome_morphology0.96462585
75MP0002106_abnormal_muscle_physiology0.95876700
76MP0010352_gastrointestinal_tract_polyps0.92948557
77MP0002128_abnormal_blood_circulation0.92834680
78MP0004742_abnormal_vestibular_system0.92796825
79MP0002928_abnormal_bile_duct0.91494065
80MP0008775_abnormal_heart_ventricle0.91185397
81MP0008875_abnormal_xenobiotic_pharmacok0.90303961
82MP0005165_increased_susceptibility_to0.88221181
83MP0005670_abnormal_white_adipose0.87044388
84MP0005508_abnormal_skeleton_morphology0.86767844
85MP0004130_abnormal_muscle_cell0.86242912
86MP0010386_abnormal_urinary_bladder0.84524562
87MP0000767_abnormal_smooth_muscle0.84095883
88MP0000747_muscle_weakness0.81257541
89MP0005595_abnormal_vascular_smooth0.80972300
90MP0001299_abnormal_eye_distance/0.80044121
91MP0005666_abnormal_adipose_tissue0.79892839
92MP0003950_abnormal_plasma_membrane0.79796823
93MP0004782_abnormal_surfactant_physiolog0.78867740
94MP0005319_abnormal_enzyme/_coenzyme0.77759785
95MP0002133_abnormal_respiratory_system0.77284003
96MP0005388_respiratory_system_phenotype0.77284003
97MP0000639_abnormal_adrenal_gland0.77257393
98MP0001544_abnormal_cardiovascular_syste0.76992942
99MP0005385_cardiovascular_system_phenoty0.76992942
100MP0000751_myopathy0.76565382
101MP0005023_abnormal_wound_healing0.76178479
102MP0005451_abnormal_body_composition0.76014226
103MP0005275_abnormal_skin_tensile0.75598549
104MP0001784_abnormal_fluid_regulation0.74660396
105MP0000538_abnormal_urinary_bladder0.74131578
106MP0001502_abnormal_circadian_rhythm0.73965213
107MP0003279_aneurysm0.73711952
108MP0005647_abnormal_sex_gland0.72863118
109MP0001614_abnormal_blood_vessel0.72347713
110MP0000013_abnormal_adipose_tissue0.71457363
111MP0002972_abnormal_cardiac_muscle0.71403748
112MP0002998_abnormal_bone_remodeling0.70708387
113MP0000163_abnormal_cartilage_morphology0.70487283
114MP0003879_abnormal_hair_cell0.70090941
115MP0002108_abnormal_muscle_morphology0.69910202
116MP0000762_abnormal_tongue_morphology0.69835052
117MP0003191_abnormal_cellular_cholesterol0.69047650
118MP0002092_abnormal_eye_morphology0.68027967
119MP0002060_abnormal_skin_morphology0.67638433
120MP0002115_abnormal_skeleton_extremities0.67251070
121MP0005375_adipose_tissue_phenotype0.67166470
122MP0000343_altered_response_to0.66205725
123MP0004085_abnormal_heartbeat0.64904684
124MP0002127_abnormal_cardiovascular_syste0.64491449
125MP0002933_joint_inflammation0.63086624
126MP0005620_abnormal_muscle_contractility0.62274972
127MP0001270_distended_abdomen0.60788232
128MP0000613_abnormal_salivary_gland0.57817727
129MP0000003_abnormal_adipose_tissue0.57533166
130MP0005584_abnormal_enzyme/coenzyme_acti0.56897796
131MP0005197_abnormal_uvea_morphology0.56345631
132MP0003828_pulmonary_edema0.54805025
133MP0002925_abnormal_cardiovascular_devel0.54650568
134MP0010630_abnormal_cardiac_muscle0.54606364
135MP0002697_abnormal_eye_size0.54262029
136MP0001915_intracranial_hemorrhage0.54204782
137MP0004215_abnormal_myocardial_fiber0.53690747
138MP0003385_abnormal_body_wall0.53450037
139MP0003137_abnormal_impulse_conducting0.53153982
140MP0003943_abnormal_hepatobiliary_system0.52716420
141MP0009278_abnormal_bone_marrow0.52191990
142MP0001727_abnormal_embryo_implantation0.50955397
143MP0005330_cardiomyopathy0.50819386

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)7.03646831
2Increased circulating renin level (HP:0000848)6.77262963
3Focal segmental glomerulosclerosis (HP:0000097)6.75611668
4Mesangial abnormality (HP:0001966)6.69945833
5Hyperactive renin-angiotensin system (HP:0000841)6.56075360
6Metabolic alkalosis (HP:0200114)6.00324549
7Abnormality of chloride homeostasis (HP:0011422)5.94775637
8Glomerulosclerosis (HP:0000096)5.81876171
9Hypomagnesemia (HP:0002917)5.80786495
10Polyuria (HP:0000103)5.36115643
11Abnormal urine output (HP:0012590)5.12839780
12Abnormality of renal excretion (HP:0011036)4.87300635
13Abnormality of magnesium homeostasis (HP:0004921)4.81440012
14Renal salt wasting (HP:0000127)4.73102743
15Gout (HP:0001997)4.72324979
16Aplasia involving bones of the extremities (HP:0009825)4.59508744
17Aplasia involving bones of the upper limbs (HP:0009823)4.59508744
18Aplasia of the phalanges of the hand (HP:0009802)4.59508744
19Tetany (HP:0001281)4.58432691
20Polydipsia (HP:0001959)4.45521289
21Abnormal drinking behavior (HP:0030082)4.45521289
22Abnormality of renin-angiotensin system (HP:0000847)4.43588535
23Hyperaldosteronism (HP:0000859)4.41531260
24Hypoalbuminemia (HP:0003073)4.21133580
25Abnormal albumin level (HP:0012116)4.21133580
26Tubular atrophy (HP:0000092)4.20460443
27Exercise-induced myalgia (HP:0003738)3.96504745
28Alkalosis (HP:0001948)3.94771217
29Muscle fiber inclusion bodies (HP:0100299)3.80236106
30Metaphyseal cupping (HP:0003021)3.75200881
31Nemaline bodies (HP:0003798)3.73722163
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.67921619
33Premature rupture of membranes (HP:0001788)3.63500807
34Type 1 muscle fiber predominance (HP:0003803)3.60597902
35* Stage 5 chronic kidney disease (HP:0003774)3.58618794
36Tubulointerstitial fibrosis (HP:0005576)3.55846887
37Hypercalciuria (HP:0002150)3.54148159
38Hypokalemia (HP:0002900)3.48341263
39Protrusio acetabuli (HP:0003179)3.48340545
40Facial shape deformation (HP:0011334)3.42499827
41Potter facies (HP:0002009)3.42499827
42Round ear (HP:0100830)3.42027005
43Lymphangioma (HP:0100764)3.37313358
44Glomerulonephritis (HP:0000099)3.32393043
45Partial duplication of the phalanx of hand (HP:0009999)3.30902819
46Aortic dissection (HP:0002647)3.24254527
47Conical tooth (HP:0000698)3.20649895
48Increased purine levels (HP:0004368)3.19272241
49Hyperuricemia (HP:0002149)3.19272241
50Abnormality of incisor morphology (HP:0011063)3.17223419
51Partial duplication of thumb phalanx (HP:0009944)3.14758601
52Proximal tubulopathy (HP:0000114)3.11080666
53Vascular tortuosity (HP:0004948)3.10070968
54Arterial tortuosity (HP:0005116)3.07903634
55Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06668792
56Abnormality of potassium homeostasis (HP:0011042)3.05165043
57Absent phalangeal crease (HP:0006109)3.05133875
58Corneal dystrophy (HP:0001131)3.03675974
59Mitral stenosis (HP:0001718)2.98944847
60Nephrocalcinosis (HP:0000121)2.97843300
61Flat cornea (HP:0007720)2.86652647
62Recurrent corneal erosions (HP:0000495)2.82185369
63Alacrima (HP:0000522)2.82088917
64Aplasia of the musculature (HP:0100854)2.77473282
65Abnormality of the radial head (HP:0003995)2.74814672
66Abnormal finger flexion creases (HP:0006143)2.72363783
67Abnormality of purine metabolism (HP:0004352)2.72099602
68Abnormality of proline metabolism (HP:0010907)2.68763131
69Hydroxyprolinuria (HP:0003080)2.68763131
70Delayed epiphyseal ossification (HP:0002663)2.66648951
71Metaphyseal dysplasia (HP:0100255)2.66038905
72Decreased lacrimation (HP:0000633)2.57660490
73Hypophosphatemia (HP:0002148)2.56449534
74Vascular calcification (HP:0004934)2.55244215
75* Nephritis (HP:0000123)2.54895026
76Chondrocalcinosis (HP:0000934)2.51194859
77* Corneal erosion (HP:0200020)2.46326592
78Cardiovascular calcification (HP:0011915)2.45856975
79Visceral angiomatosis (HP:0100761)2.44318252
80Gonadal dysgenesis (HP:0000133)2.42857120
81Mixed hearing impairment (HP:0000410)2.42051877
82Interstitial pulmonary disease (HP:0006530)2.34996575
83Abnormality of Sharpey fibers (HP:0100685)2.34870276
84Hyperglycinuria (HP:0003108)2.34087507
85Hyporeflexia of lower limbs (HP:0002600)2.33039239
86Decreased circulating renin level (HP:0003351)2.32809038
87Soft skin (HP:0000977)2.29408690
88Increased connective tissue (HP:0009025)2.29106989
89Distal arthrogryposis (HP:0005684)2.27020748
90Bladder diverticulum (HP:0000015)2.24858654
91Hyperextensible skin (HP:0000974)2.23595524
92Hemangiomatosis (HP:0007461)2.23238484
93Shallow orbits (HP:0000586)2.23094661
94Tubulointerstitial abnormality (HP:0001969)2.22938282
95Atrophic scars (HP:0001075)2.21815724
96Abnormality of sodium homeostasis (HP:0010931)2.19093042
97* Proteinuria (HP:0000093)2.16830146
98Fragile skin (HP:0001030)2.16703190
99Hypoplasia of the iris (HP:0007676)2.16608815
100Wormian bones (HP:0002645)2.16331061
101Ankle contracture (HP:0006466)2.14763546
102Nonprogressive disorder (HP:0003680)2.14666670
103Generalized aminoaciduria (HP:0002909)2.14521195
104Exercise-induced muscle cramps (HP:0003710)2.13706412
105Asymmetric septal hypertrophy (HP:0001670)2.12792143
106Adrenal overactivity (HP:0002717)2.09386050
107Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.09033894
108Abnormal tarsal ossification (HP:0008369)2.07881584
109Broad hallux (HP:0010055)2.06600050
110Muscle hypertrophy of the lower extremities (HP:0008968)2.06269037
111Renal tubular acidosis (HP:0001947)2.06073293
112Thin bony cortex (HP:0002753)2.05710905
113Polycythemia (HP:0001901)2.04581388
114Hematochezia (HP:0002573)2.04507844
115Hyponatremia (HP:0002902)2.03539873
116Camptodactyly of toe (HP:0001836)2.01481208
117Muscle fiber splitting (HP:0003555)1.98845037
118Neonatal respiratory distress (HP:0002643)1.98485528
119Nasolacrimal duct obstruction (HP:0000579)1.96232132
120Hyperkalemia (HP:0002153)1.95812813
121Ketoacidosis (HP:0001993)1.95765162
122Hypoproteinemia (HP:0003075)1.94703808
123Abnormality of the salivary glands (HP:0010286)1.94610201
124EMG: myopathic abnormalities (HP:0003458)1.93583153
125Cubitus valgus (HP:0002967)1.93210109
126Hip contracture (HP:0003273)1.92654929
127* Nephrotic syndrome (HP:0000100)1.92519325
128Calf muscle hypertrophy (HP:0008981)1.92276428
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.92194044
130Osteolytic defects of the hand bones (HP:0009699)1.92194044
131Bicornuate uterus (HP:0000813)1.92179130
132Myoglobinuria (HP:0002913)1.92140163
133Abnormality of the calf musculature (HP:0001430)1.88590181
134Aortic aneurysm (HP:0004942)1.87922248
135Male infertility (HP:0003251)1.86376585
136Vertebral compression fractures (HP:0002953)1.84533350
137Abnormal urine phosphate concentration (HP:0012599)1.84129620
138Subaortic stenosis (HP:0001682)1.83994057
139Abnormality of the left ventricular outflow tract (HP:0011103)1.83994057
140Difficulty running (HP:0009046)1.82976734
141Abnormality of molar (HP:0011077)1.81773419
142Abnormality of molar morphology (HP:0011070)1.81773419
143Dislocated radial head (HP:0003083)1.81036291
144Limited elbow extension (HP:0001377)1.80758221
145Ulnar bowing (HP:0003031)1.80243653
146Nephrolithiasis (HP:0000787)1.79947461
147Hand muscle atrophy (HP:0009130)1.79102596
148Increased variability in muscle fiber diameter (HP:0003557)1.78425543
149Striae distensae (HP:0001065)1.78405631
150Centrally nucleated skeletal muscle fibers (HP:0003687)1.78373922
151Increased corneal curvature (HP:0100692)1.78328654
152Keratoconus (HP:0000563)1.78328654
153Dehydration (HP:0001944)1.77222762
154Abnormality of glycine metabolism (HP:0010895)1.76400143
155Abnormality of serine family amino acid metabolism (HP:0010894)1.76400143
156Taurodontia (HP:0000679)1.75202389
157Abnormality of permanent molar morphology (HP:0011071)1.75202389
158Rapidly progressive (HP:0003678)1.75099073
159Hyperphosphaturia (HP:0003109)1.75074868
160Testicular neoplasm (HP:0010788)1.73766710
161Abnormality of nucleobase metabolism (HP:0010932)1.72283830
162Abnormality of fatty-acid metabolism (HP:0004359)1.72008313
163Polar cataract (HP:0010696)1.69937978
164Rectal prolapse (HP:0002035)1.69919511
165Generalized muscle weakness (HP:0003324)1.68624988
166Glycosuria (HP:0003076)1.67500929
167Abnormality of urine glucose concentration (HP:0011016)1.67500929
168Abnormality of the fingertips (HP:0001211)1.66497648
169Persistence of primary teeth (HP:0006335)1.66371235
170Germ cell neoplasia (HP:0100728)1.66218410
171Broad metatarsal (HP:0001783)1.64799830
172* Hematuria (HP:0000790)1.64248377
173Cerebral aneurysm (HP:0004944)1.64150109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.31942905
2WNK36.04381283
3OXSR15.77813154
4OBSCN4.41229464
5STK393.98572515
6TIE13.33196464
7EPHB22.91871174
8TGFBR22.71239916
9MYLK2.59054517
10TRPM72.32647363
11PAK42.27884913
12PHKG11.99274098
13PHKG21.99274098
14STK38L1.89728788
15MOS1.77620108
16LATS11.77454325
17TRIB31.76983811
18WNK11.76071041
19MAPK71.73972334
20EPHA31.73238395
21EPHB11.70245181
22EEF2K1.66967245
23AKT31.58065921
24RIPK11.53684830
25MAP3K131.43793073
26PDGFRA1.41419985
27PIK3CG1.40205750
28PDK41.38612414
29PDK31.38612414
30MELK1.38533838
31MAPK121.35277395
32KDR1.35069750
33PTK61.31023994
34PDK21.30927475
35MUSK1.29978402
36FGFR41.20621587
37MST41.19166688
38MAPKAPK51.19161528
39NLK1.18781329
40SGK4941.12806183
41SGK2231.12806183
42LRRK21.07026012
43TYRO31.06568835
44FER1.04699390
45TGFBR11.04070280
46CDK120.99178036
47RPS6KC10.98496193
48RPS6KL10.98496193
49BCKDK0.93632046
50SGK30.90417794
51MAP3K70.90192399
52RPS6KA20.89988291
53GSK3A0.89388906
54PRKD30.87919158
55CDC42BPA0.86533026
56MAP3K140.86161782
57RPS6KA60.84280661
58SGK20.83683394
59TTN0.83368461
60MARK20.81526667
61ERN10.81088889
62RET0.80461634
63MAP3K60.78616526
64CCNB10.78042951
65PTK20.77285861
66TBK10.76767839
67PTK2B0.75265859
68ROCK10.75220824
69GRK50.73584977
70NME10.73135169
71PAK30.72986448
72MAPK110.72903943
73MAPK150.72828922
74MST1R0.72812900
75NTRK10.72607603
76FRK0.70772652
77STK380.68145904
78PAK20.66906153
79TYK20.66736852
80MAP4K20.63128949
81MAPKAPK30.62680489
82STK30.61492486
83PRKD20.61467528
84STK100.60905089
85PDGFRB0.60774699
86FGFR20.60588041
87CAMK1G0.59953518
88PRKCH0.58822882
89MAP3K30.56867574
90BMX0.53018342
91DAPK20.52919844
92MET0.52321401
93MTOR0.49816524
94ICK0.49816211
95DMPK0.49402317
96SCYL20.49057714
97LMTK20.48127618
98NEK60.47744470
99MAPK40.47057722
100IRAK10.44823171
101GRK70.44574331
102PDPK10.43763994
103SIK10.41173274
104MAP2K60.40023505
105EIF2AK20.39686996
106CAMK1D0.39489885
107SMG10.39251655
108NEK90.38840699
109MAP3K90.38307301
110PRPF4B0.37972355
111GRK10.37409014
112PRKD10.35741032
113MAP2K20.35574571
114CSK0.33228027
115SGK10.32458221
116LATS20.32355917
117MAPK30.31915159
118NEK10.31678695
119TLK10.30688764
120CAMK2B0.30478164
121FGFR30.30439812
122MAP2K10.30285967
123JAK10.29697744
124ABL20.29280673
125EGFR0.28218117
126FGFR10.25241378
127PRKAA10.25164906
128PRKAA20.23939964
129PKN20.23706315
130SRC0.23438396
131MAP3K20.23388460
132PRKCE0.23188055
133ABL10.21959070
134KIT0.20490381
135DYRK1B0.20056415
136ZAP700.19847149
137JAK20.19831288
138AKT20.18890586
139PRKACG0.18310361
140PRKACB0.18059286
141MAP2K30.17088974
142DDR20.16495768
143CHUK0.16001102
144PINK10.15913367
145PDK10.15566692
146IGF1R0.14679911

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.03538649
2Circadian rhythm_Homo sapiens_hsa047102.85507044
3* ECM-receptor interaction_Homo sapiens_hsa045122.79581912
4Propanoate metabolism_Homo sapiens_hsa006402.50079980
5Renin-angiotensin system_Homo sapiens_hsa046142.44859994
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.38075679
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37818271
8Butanoate metabolism_Homo sapiens_hsa006502.35862719
9* Protein digestion and absorption_Homo sapiens_hsa049742.32520488
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30386056
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.29940916
12Fatty acid degradation_Homo sapiens_hsa000712.13662582
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.05327327
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04374479
15Vitamin digestion and absorption_Homo sapiens_hsa049771.95670356
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81952822
17Lysine degradation_Homo sapiens_hsa003101.80885445
18Fatty acid metabolism_Homo sapiens_hsa012121.76759868
19* Focal adhesion_Homo sapiens_hsa045101.75662216
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70772522
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70494472
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65420509
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62261088
24Tryptophan metabolism_Homo sapiens_hsa003801.61128622
25Pyruvate metabolism_Homo sapiens_hsa006201.57589728
26Mineral absorption_Homo sapiens_hsa049781.56676391
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56545493
28Bile secretion_Homo sapiens_hsa049761.55415456
29* Small cell lung cancer_Homo sapiens_hsa052221.49057443
30Melanoma_Homo sapiens_hsa052181.43519664
31Peroxisome_Homo sapiens_hsa041461.36826451
32Pentose phosphate pathway_Homo sapiens_hsa000301.36796727
33Collecting duct acid secretion_Homo sapiens_hsa049661.35938070
34* Amoebiasis_Homo sapiens_hsa051461.33556589
35PPAR signaling pathway_Homo sapiens_hsa033201.27394027
36Glucagon signaling pathway_Homo sapiens_hsa049221.20418224
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19778084
38beta-Alanine metabolism_Homo sapiens_hsa004101.15963406
39Axon guidance_Homo sapiens_hsa043601.15846746
40Fructose and mannose metabolism_Homo sapiens_hsa000511.15054316
41* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09216079
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05120836
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01140553
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00678664
45Dilated cardiomyopathy_Homo sapiens_hsa054141.00052537
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99917034
47Gastric acid secretion_Homo sapiens_hsa049710.98082269
48Thyroid hormone synthesis_Homo sapiens_hsa049180.97359499
49Inositol phosphate metabolism_Homo sapiens_hsa005620.94782404
50Glutathione metabolism_Homo sapiens_hsa004800.94461235
51Tight junction_Homo sapiens_hsa045300.93428053
52Adherens junction_Homo sapiens_hsa045200.93232382
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.91410687
54Other glycan degradation_Homo sapiens_hsa005110.90997795
55Insulin signaling pathway_Homo sapiens_hsa049100.89834820
56Dorso-ventral axis formation_Homo sapiens_hsa043200.85754474
57Vitamin B6 metabolism_Homo sapiens_hsa007500.85408139
58Sulfur metabolism_Homo sapiens_hsa009200.85131234
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84282971
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.83595423
61Lysosome_Homo sapiens_hsa041420.82768858
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81872754
63Proteoglycans in cancer_Homo sapiens_hsa052050.81004658
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79970422
65Carbon metabolism_Homo sapiens_hsa012000.79501153
66Starch and sucrose metabolism_Homo sapiens_hsa005000.74939077
67Bladder cancer_Homo sapiens_hsa052190.74552640
68FoxO signaling pathway_Homo sapiens_hsa040680.72940785
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72771939
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71204866
71Basal cell carcinoma_Homo sapiens_hsa052170.70618749
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69875231
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69780010
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.69427595
75Hippo signaling pathway_Homo sapiens_hsa043900.68136865
76Phenylalanine metabolism_Homo sapiens_hsa003600.67417146
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67366123
78MAPK signaling pathway_Homo sapiens_hsa040100.66593527
79GnRH signaling pathway_Homo sapiens_hsa049120.66265452
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.64712786
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63870124
82Arginine and proline metabolism_Homo sapiens_hsa003300.63644698
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63572764
84* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63345993
85Renin secretion_Homo sapiens_hsa049240.62712398
86Glycerolipid metabolism_Homo sapiens_hsa005610.62350163
87Prostate cancer_Homo sapiens_hsa052150.60996517
88Galactose metabolism_Homo sapiens_hsa000520.60893713
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60772125
90Hedgehog signaling pathway_Homo sapiens_hsa043400.60335105
91Insulin resistance_Homo sapiens_hsa049310.60006153
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58589078
93Viral myocarditis_Homo sapiens_hsa054160.58275796
94Rap1 signaling pathway_Homo sapiens_hsa040150.56759410
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55148671
96ABC transporters_Homo sapiens_hsa020100.54253746
97Selenocompound metabolism_Homo sapiens_hsa004500.53293246
98Arachidonic acid metabolism_Homo sapiens_hsa005900.52763428
99Oxytocin signaling pathway_Homo sapiens_hsa049210.51732050
100Complement and coagulation cascades_Homo sapiens_hsa046100.51406338
101Chronic myeloid leukemia_Homo sapiens_hsa052200.51377767
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.50884310
103Systemic lupus erythematosus_Homo sapiens_hsa053220.49565910
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47766703
105Pancreatic cancer_Homo sapiens_hsa052120.47545262
106TGF-beta signaling pathway_Homo sapiens_hsa043500.47422755
107Nitrogen metabolism_Homo sapiens_hsa009100.47022073
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46976406
109Calcium signaling pathway_Homo sapiens_hsa040200.46762970
110Fatty acid elongation_Homo sapiens_hsa000620.46657516
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46512862
112B cell receptor signaling pathway_Homo sapiens_hsa046620.46326191
113HIF-1 signaling pathway_Homo sapiens_hsa040660.45969409
114Biosynthesis of amino acids_Homo sapiens_hsa012300.45799385
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45656212
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45410840
117Histidine metabolism_Homo sapiens_hsa003400.45387732
118AMPK signaling pathway_Homo sapiens_hsa041520.45275708
119mTOR signaling pathway_Homo sapiens_hsa041500.45011897
120Salivary secretion_Homo sapiens_hsa049700.44563512
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44198667
122Retinol metabolism_Homo sapiens_hsa008300.43780403
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43648698
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43636763
125Non-small cell lung cancer_Homo sapiens_hsa052230.43564580
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43320747
127Toxoplasmosis_Homo sapiens_hsa051450.43015773
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42586966
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.42544438
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.41498602
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41415767
132Notch signaling pathway_Homo sapiens_hsa043300.40496865
133* Pathways in cancer_Homo sapiens_hsa052000.40442940
134Cardiac muscle contraction_Homo sapiens_hsa042600.39940714
135MicroRNAs in cancer_Homo sapiens_hsa052060.39567552
136Arginine biosynthesis_Homo sapiens_hsa002200.38022742
137Choline metabolism in cancer_Homo sapiens_hsa052310.37802120
138Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37471036
139Chemical carcinogenesis_Homo sapiens_hsa052040.37448232
140Ovarian steroidogenesis_Homo sapiens_hsa049130.36968319
141Renal cell carcinoma_Homo sapiens_hsa052110.32416531

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