COL4A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)5.17863563
2glomerular visceral epithelial cell development (GO:0072015)4.60206316
3collagen fibril organization (GO:0030199)4.43434160
4lateral sprouting from an epithelium (GO:0060601)4.42173172
5protein heterotrimerization (GO:0070208)4.41456266
6cell adhesion mediated by integrin (GO:0033627)4.31003898
7glomerular epithelial cell development (GO:0072310)4.30001757
8epithelial cell-cell adhesion (GO:0090136)4.21272939
9plasma membrane repair (GO:0001778)4.13554969
10notochord development (GO:0030903)3.96746016
11chondrocyte proliferation (GO:0035988)3.94114779
12retina vasculature morphogenesis in camera-type eye (GO:0061299)3.91551582
13endodermal cell differentiation (GO:0035987)3.90552864
14cardiac myofibril assembly (GO:0055003)3.89668345
15neuron projection extension involved in neuron projection guidance (GO:1902284)3.85591681
16axon extension involved in axon guidance (GO:0048846)3.85591681
17basement membrane organization (GO:0071711)3.85085692
18kidney mesenchyme development (GO:0072074)3.75269525
19Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.60771745
20positive regulation of endothelial cell apoptotic process (GO:2000353)3.59222427
21hippo signaling (GO:0035329)3.57322214
22wound healing, spreading of epidermal cells (GO:0035313)3.54374142
23dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.52852840
24convergent extension (GO:0060026)3.52095611
25regulation of establishment of planar polarity (GO:0090175)3.49491605
26vascular endothelial growth factor signaling pathway (GO:0038084)3.42918734
27sarcomere organization (GO:0045214)3.42417769
28wound healing, spreading of cells (GO:0044319)3.41020823
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.40161915
30regulation of transforming growth factor beta2 production (GO:0032909)3.37919885
31renal filtration (GO:0097205)3.37423691
32* collagen metabolic process (GO:0032963)3.37281273
33pattern specification involved in kidney development (GO:0061004)3.35115221
34cell migration involved in sprouting angiogenesis (GO:0002042)3.33301269
35non-canonical Wnt signaling pathway (GO:0035567)3.32582875
36* collagen catabolic process (GO:0030574)3.30143499
37limb bud formation (GO:0060174)3.29152081
38insulin-like growth factor receptor signaling pathway (GO:0048009)3.28715922
39hemidesmosome assembly (GO:0031581)3.28149289
40skin morphogenesis (GO:0043589)3.25975488
41embryonic foregut morphogenesis (GO:0048617)3.25699614
42* multicellular organismal macromolecule metabolic process (GO:0044259)3.23648120
43endocardial cushion development (GO:0003197)3.21367305
44atrioventricular valve morphogenesis (GO:0003181)3.21279524
45bundle of His cell to Purkinje myocyte communication (GO:0086069)3.20162711
46branching involved in salivary gland morphogenesis (GO:0060445)3.19536968
47regulation of cardioblast differentiation (GO:0051890)3.19329561
48bone trabecula formation (GO:0060346)3.15920640
49regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.15860643
50negative regulation of chondrocyte differentiation (GO:0032331)3.15645118
51apical protein localization (GO:0045176)3.14432938
52cell surface receptor signaling pathway involved in heart development (GO:0061311)3.13706984
53regulation of non-canonical Wnt signaling pathway (GO:2000050)3.13477717
54epoxygenase P450 pathway (GO:0019373)3.12522969
55sequestering of extracellular ligand from receptor (GO:0035581)3.12270273
56* multicellular organismal catabolic process (GO:0044243)3.10633767
57lymph vessel development (GO:0001945)3.09871063
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.06483777
59myofibril assembly (GO:0030239)3.06060614
60* multicellular organismal metabolic process (GO:0044236)3.05565862
61negative regulation of fatty acid transport (GO:2000192)3.05053601
62metanephric mesenchyme development (GO:0072075)3.00340734
63mesenchymal cell proliferation (GO:0010463)3.00242295
64atrial septum morphogenesis (GO:0060413)2.98727911
65* extracellular matrix disassembly (GO:0022617)2.97915775
66gap junction assembly (GO:0016264)2.97787009
67negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.97439532
68regulation of hippo signaling (GO:0035330)2.96883996
69mesodermal cell differentiation (GO:0048333)2.94481372
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.94033065
71positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.93702134
72cell-substrate junction assembly (GO:0007044)2.93628475
73stress fiber assembly (GO:0043149)2.91664864
74cytoskeletal anchoring at plasma membrane (GO:0007016)2.90822159
75polarized epithelial cell differentiation (GO:0030859)2.86727755
76endothelial cell morphogenesis (GO:0001886)2.86475325
77craniofacial suture morphogenesis (GO:0097094)2.84779593
78establishment of apical/basal cell polarity (GO:0035089)2.84731899
79endothelial cell chemotaxis (GO:0035767)2.84574102
80cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.84419929
81glomerular filtration (GO:0003094)2.83986918
82actomyosin structure organization (GO:0031032)2.83711134
83dorsal/ventral axis specification (GO:0009950)2.83149470
84lung-associated mesenchyme development (GO:0060484)2.80502537
85negative regulation of axon guidance (GO:1902668)2.80148624
86cellular response to vitamin (GO:0071295)2.79481615
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77044814
88lymphangiogenesis (GO:0001946)2.76996900
89apoptotic cell clearance (GO:0043277)2.76690671
90artery development (GO:0060840)2.76553646
91negative chemotaxis (GO:0050919)2.75805543
92cell proliferation involved in metanephros development (GO:0072203)2.75236510
93embryonic retina morphogenesis in camera-type eye (GO:0060059)2.72242659
94camera-type eye morphogenesis (GO:0048593)2.71931702
95mesenchymal-epithelial cell signaling (GO:0060638)2.71927778
96midgut development (GO:0007494)2.71773316
97negative regulation of keratinocyte proliferation (GO:0010839)2.70902980
98adherens junction assembly (GO:0034333)2.70071443
99protein localization to cell surface (GO:0034394)2.69657050
100positive regulation of extracellular matrix organization (GO:1903055)2.69247058
101regulation of heart morphogenesis (GO:2000826)2.68893754
102positive regulation of epithelial to mesenchymal transition (GO:0010718)2.68450275
103substrate adhesion-dependent cell spreading (GO:0034446)2.68411060
104asymmetric protein localization (GO:0008105)2.68381793
105regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.68375086
106negative regulation of axon extension involved in axon guidance (GO:0048843)2.67785778
107axis elongation (GO:0003401)2.67182672
108tongue development (GO:0043586)2.67010521
109cellular response to vitamin D (GO:0071305)2.66806106
110mesenchyme morphogenesis (GO:0072132)2.65470813
111negative regulation of striated muscle cell apoptotic process (GO:0010664)2.63965924
112trabecula formation (GO:0060343)2.63902627
113regulation of axon extension involved in axon guidance (GO:0048841)2.63772084
114desmosome organization (GO:0002934)2.62984162
115cardiac muscle cell proliferation (GO:0060038)2.62521190
116presynaptic membrane assembly (GO:0097105)2.62165200
117prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.61798255
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60527664
119mesenchyme development (GO:0060485)2.60224805
120establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59636756
121paraxial mesoderm development (GO:0048339)2.59414065
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.59135120
123blood vessel endothelial cell migration (GO:0043534)2.59124842
124cochlea morphogenesis (GO:0090103)2.58762489
125radial glial cell differentiation (GO:0060019)2.58753871
126heart trabecula formation (GO:0060347)2.58255778
127positive regulation of catenin import into nucleus (GO:0035413)2.56419755
128fibroblast migration (GO:0010761)2.56134373
129regulation of tight junction assembly (GO:2000810)2.55364026
130* extracellular matrix organization (GO:0030198)2.54388383
131establishment of monopolar cell polarity (GO:0061162)2.54082514
132establishment or maintenance of monopolar cell polarity (GO:0061339)2.54082514
133* extracellular structure organization (GO:0043062)2.53260689
134positive regulation of mesenchymal cell proliferation (GO:0002053)2.53238949
135glomerulus development (GO:0032835)2.53121300
136negative regulation of cell fate specification (GO:0009996)2.52667334
137heart morphogenesis (GO:0003007)2.51836753
138lens fiber cell development (GO:0070307)2.51335668
139otic vesicle formation (GO:0030916)2.51168591
140positive regulation of canonical Wnt signaling pathway (GO:0090263)2.50670877
141germ cell migration (GO:0008354)2.49955236
142morphogenesis of an epithelial sheet (GO:0002011)2.49555233
143negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.49094545
144regulation of axon guidance (GO:1902667)2.48673141
145establishment of planar polarity (GO:0001736)2.48517822
146establishment of tissue polarity (GO:0007164)2.48517822
147omega-hydroxylase P450 pathway (GO:0097267)2.47835852
148endocardial cushion morphogenesis (GO:0003203)2.42934562
149positive regulation of smoothened signaling pathway (GO:0045880)2.40399568
150neuronal stem cell maintenance (GO:0097150)2.39971231
151establishment of nucleus localization (GO:0040023)2.38998367
152negative regulation of cartilage development (GO:0061037)2.37704582
153myoblast fusion (GO:0007520)2.36182366
154digestive tract morphogenesis (GO:0048546)2.35029731
155cranial suture morphogenesis (GO:0060363)2.34999067
156post-anal tail morphogenesis (GO:0036342)2.33504126
157mesenchymal cell differentiation (GO:0048762)2.33035537
158renal system development (GO:0072001)2.32344846
159gastrulation with mouth forming second (GO:0001702)2.31530681
160neural crest cell development (GO:0014032)2.30077144
161muscle cell proliferation (GO:0033002)2.27659673
162genitalia morphogenesis (GO:0035112)2.27640550
163outflow tract septum morphogenesis (GO:0003148)2.27172903
164mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.26605546
165positive regulation of cardiac muscle tissue development (GO:0055025)2.26500200
166midbrain development (GO:0030901)2.26310283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.56969991
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.17895028
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.82760848
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.37782008
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.04762002
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.97317189
7CLOCK_20551151_ChIP-Seq_293T_Human2.93406841
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40741117
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.40187313
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.37252729
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.24212718
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.20268839
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.19517811
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.16433367
15CJUN_26792858_Chip-Seq_BT549_Human2.14521701
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.13423695
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.99655873
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.96670222
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93013966
20* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.92457775
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.88174437
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85394611
23CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.78112549
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76965448
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75794792
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73913614
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73165777
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.70069036
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67423863
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.67212302
31TBX20_22080862_ChIP-Seq_HEART_Mouse1.67212302
32BRD4_25478319_ChIP-Seq_HGPS_Human1.62205682
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60935465
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60094276
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60094276
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.60089540
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58630722
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.56397534
39EZH2_22144423_ChIP-Seq_EOC_Human1.55350811
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54859188
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54859188
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.54038374
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53020085
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53020085
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52790546
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.51188437
47AR_21909140_ChIP-Seq_LNCAP_Human1.49758341
48TP53_16413492_ChIP-PET_HCT116_Human1.49390290
49GBX2_23144817_ChIP-Seq_PC3_Human1.48808992
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46009222
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.43852821
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42431049
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.41035305
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40330783
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.40160720
56* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.38457798
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38218768
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38137747
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38099610
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37900852
61TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37823245
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.36896335
63AHR_22903824_ChIP-Seq_MCF-7_Human1.36441859
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35408189
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34534232
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34279613
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33901971
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33316820
69TP53_18474530_ChIP-ChIP_U2OS_Human1.32977813
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32384038
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32326011
72ZNF263_19887448_ChIP-Seq_K562_Human1.30962433
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30746325
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.29125750
75SOX2_20726797_ChIP-Seq_SW620_Human1.28710208
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.27832244
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27381303
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26927635
79TAF15_26573619_Chip-Seq_HEK293_Human1.26672171
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26034414
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25888334
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25688258
83TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25186773
84FUS_26573619_Chip-Seq_HEK293_Human1.24176551
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23339833
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23234374
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22527437
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22474359
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.22421738
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22067995
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21449394
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.21418481
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21229272
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20705637
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20695519
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19921073
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19670825
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19364051
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.18273235
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18250088
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16918397
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15690071
103RNF2_27304074_Chip-Seq_NSC_Mouse1.15129813
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.14783898
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14507383
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11564472
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10211305
108SOX9_26525672_Chip-Seq_HEART_Mouse1.10083991
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09631331
110SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08791136
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08722201
112* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08346605
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.08309114
114KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08283196
115KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08283196
116KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08283196
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08051438
118* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07600213
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07394578
120TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06943060
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06751411
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06322717
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.05652533
124ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05256067
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04999003
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04906934
127SMAD4_21799915_ChIP-Seq_A2780_Human1.04608262
128SMAD4_21741376_ChIP-Seq_HESCs_Human1.03765810
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03230344
130TCF4_18268006_ChIP-ChIP_LS174T_Human1.03143670
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02936903
132TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02854241
133RNF2_27304074_Chip-Seq_ESCs_Mouse1.02774271
134EGR1_19374776_ChIP-ChIP_THP-1_Human1.02419905
135RACK7_27058665_Chip-Seq_MCF-7_Human1.01834426
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01755384
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01708332
138AR_21572438_ChIP-Seq_LNCaP_Human1.01675839
139ATF3_27146783_Chip-Seq_COLON_Human1.01484531
140KDM2B_26808549_Chip-Seq_K562_Human1.00474727
141EZH2_27304074_Chip-Seq_ESCs_Mouse1.00409402
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00107429
143* TP53_23651856_ChIP-Seq_MEFs_Mouse0.99408471
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98667791
145RXR_22108803_ChIP-Seq_LS180_Human0.98626905
146KLF5_25053715_ChIP-Seq_YYC3_Human0.97783817
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.97736742
148MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96909807
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96353677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.67691151
2MP0000566_synostosis4.54694590
3MP0005275_abnormal_skin_tensile3.84724163
4MP0004272_abnormal_basement_membrane3.68113072
5MP0005623_abnormal_meninges_morphology3.67495376
6MP0005503_abnormal_tendon_morphology3.45984980
7MP0000579_abnormal_nail_morphology3.34110726
8MP0003705_abnormal_hypodermis_morpholog3.22240259
9MP0003279_aneurysm2.95769142
10MP0001958_emphysema2.82665833
11MP0004084_abnormal_cardiac_muscle2.78913648
12MP0009384_cardiac_valve_regurgitation2.64191519
13MP0003566_abnormal_cell_adhesion2.14506835
14MP0006054_spinal_hemorrhage2.08973690
15MP0000751_myopathy1.82400919
16MP0003385_abnormal_body_wall1.80241580
17MP0003941_abnormal_skin_development1.78611789
18MP0003122_maternal_imprinting1.74158628
19MP0010352_gastrointestinal_tract_polyps1.70905869
20MP0000534_abnormal_ureter_morphology1.70844941
21MP0006138_congestive_heart_failure1.68593117
22MP0010368_abnormal_lymphatic_system1.67658949
23MP0000537_abnormal_urethra_morphology1.65508471
24MP0002938_white_spotting1.64941746
25MP0001293_anophthalmia1.63691899
26MP0005330_cardiomyopathy1.63164904
27MP0005508_abnormal_skeleton_morphology1.60196407
28MP0001879_abnormal_lymphatic_vessel1.58854017
29MP0010030_abnormal_orbit_morphology1.57894898
30MP0003091_abnormal_cell_migration1.57652059
31MP0003942_abnormal_urinary_system1.56910172
32MP0002295_abnormal_pulmonary_circulatio1.55908345
33MP0005257_abnormal_intraocular_pressure1.55690905
34MP0004036_abnormal_muscle_relaxation1.54657668
35MP0002060_abnormal_skin_morphology1.54128098
36MP0001346_abnormal_lacrimal_gland1.52873284
37MP0000767_abnormal_smooth_muscle1.50967762
38MP0000778_abnormal_nervous_system1.47950604
39MP0008775_abnormal_heart_ventricle1.47271046
40MP0002837_dystrophic_cardiac_calcinosis1.45877089
41MP0000733_abnormal_muscle_development1.44133516
42MP0003136_yellow_coat_color1.44096491
43MP0002972_abnormal_cardiac_muscle1.42020509
44MP0010630_abnormal_cardiac_muscle1.41329398
45MP0006292_abnormal_olfactory_placode1.40744656
46MP0000750_abnormal_muscle_regeneration1.39820417
47MP0004087_abnormal_muscle_fiber1.39011880
48MP0010234_abnormal_vibrissa_follicle1.38214917
49MP0002108_abnormal_muscle_morphology1.38025946
50MP0000462_abnormal_digestive_system1.37525968
51MP0003828_pulmonary_edema1.37309244
52MP0004215_abnormal_myocardial_fiber1.36720821
53MP0003115_abnormal_respiratory_system1.36093844
54MP0009250_abnormal_appendicular_skeleto1.35238728
55MP0000049_abnormal_middle_ear1.32624018
56MP0005023_abnormal_wound_healing1.32519587
57MP0002697_abnormal_eye_size1.31901996
58MP0001286_abnormal_eye_development1.29787989
59MP0002282_abnormal_trachea_morphology1.26242389
60MP0003119_abnormal_digestive_system1.25221892
61MP0008789_abnormal_olfactory_epithelium1.24977091
62MP0002896_abnormal_bone_mineralization1.24366838
63MP0003890_abnormal_embryonic-extraembry1.24338714
64MP0003938_abnormal_ear_development1.23480640
65MP0001544_abnormal_cardiovascular_syste1.23325616
66MP0005385_cardiovascular_system_phenoty1.23325616
67MP0009053_abnormal_anal_canal1.22725312
68MP0005620_abnormal_muscle_contractility1.19836082
69MP0000428_abnormal_craniofacial_morphol1.14556427
70MP0002128_abnormal_blood_circulation1.13291722
71MP0003045_fibrosis1.12371515
72MP0002084_abnormal_developmental_patter1.12026009
73MP0001849_ear_inflammation1.11736938
74MP0000749_muscle_degeneration1.11624238
75MP0003567_abnormal_fetal_cardiomyocyte1.10159828
76MP0003283_abnormal_digestive_organ1.08607297
77MP0001177_atelectasis1.08536043
78MP0004858_abnormal_nervous_system1.07862436
79MP0004233_abnormal_muscle_weight1.05086800
80MP0002111_abnormal_tail_morphology1.05059808
81MP0005394_taste/olfaction_phenotype1.04383015
82MP0005499_abnormal_olfactory_system1.04383015
83MP0001299_abnormal_eye_distance/1.04363404
84MP0002932_abnormal_joint_morphology1.01726653
85MP0000762_abnormal_tongue_morphology1.01623002
86MP0005409_darkened_coat_color1.01159459
87MP0003861_abnormal_nervous_system1.00884801
88MP0000383_abnormal_hair_follicle1.00438495
89MP0004130_abnormal_muscle_cell0.99834918
90MP0010678_abnormal_skin_adnexa0.98491404
91MP0005193_abnormal_anterior_eye0.97645827
92MP0002168_other_aberrant_phenotype0.97556207
93MP0002925_abnormal_cardiovascular_devel0.96867245
94MP0002234_abnormal_pharynx_morphology0.96774466
95MP0000013_abnormal_adipose_tissue0.96037757
96MP0009780_abnormal_chondrocyte_physiolo0.95807635
97MP0005197_abnormal_uvea_morphology0.95797113
98* MP0001614_abnormal_blood_vessel0.95541633
99MP0000163_abnormal_cartilage_morphology0.95388408
100MP0003300_gastrointestinal_ulcer0.95134166
101MP0002085_abnormal_embryonic_tissue0.94795792
102MP0002249_abnormal_larynx_morphology0.93258647
103MP0003315_abnormal_perineum_morphology0.92792771
104MP0002098_abnormal_vibrissa_morphology0.92397805
105MP0003935_abnormal_craniofacial_develop0.92387321
106MP0004484_altered_response_of0.91915309
107MP0002109_abnormal_limb_morphology0.90790936
108MP0005076_abnormal_cell_differentiation0.89838739
109MP0000467_abnormal_esophagus_morphology0.89706463
110MP0000266_abnormal_heart_morphology0.88373699
111MP0004133_heterotaxia0.86898893
112MP0009703_decreased_birth_body0.86599188
113MP0002233_abnormal_nose_morphology0.86388821
114MP0000003_abnormal_adipose_tissue0.85843318
115MP0003755_abnormal_palate_morphology0.84464957
116MP0002115_abnormal_skeleton_extremities0.84270629
117MP0005171_absent_coat_pigmentation0.83479588
118MP0002877_abnormal_melanocyte_morpholog0.83112537
119MP0002133_abnormal_respiratory_system0.82569542
120MP0005388_respiratory_system_phenotype0.82569542
121MP0000432_abnormal_head_morphology0.82525075
122MP0009672_abnormal_birth_weight0.82400621
123MP0001915_intracranial_hemorrhage0.81683769
124MP0003950_abnormal_plasma_membrane0.80775755
125MP0003937_abnormal_limbs/digits/tail_de0.79968300
126MP0003137_abnormal_impulse_conducting0.79157856
127MP0003984_embryonic_growth_retardation0.78108966
128MP0005369_muscle_phenotype0.77623050
129MP0000026_abnormal_inner_ear0.77615696
130MP0002088_abnormal_embryonic_growth/wei0.77413493
131MP0000516_abnormal_urinary_system0.77370988
132MP0005367_renal/urinary_system_phenotyp0.77370988
133MP0002092_abnormal_eye_morphology0.77076998
134MP0005248_abnormal_Harderian_gland0.76409602
135MP0005595_abnormal_vascular_smooth0.76340249
136MP0005391_vision/eye_phenotype0.76042156
137MP0002114_abnormal_axial_skeleton0.74478498
138MP0002089_abnormal_postnatal_growth/wei0.74270613
139MP0002116_abnormal_craniofacial_bone0.73431443
140MP0005380_embryogenesis_phenotype0.72923657
141MP0001672_abnormal_embryogenesis/_devel0.72923657
142MP0001340_abnormal_eyelid_morphology0.72562055
143MP0002081_perinatal_lethality0.69499686

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.05844744
2Premature rupture of membranes (HP:0001788)5.98082165
3Ankle contracture (HP:0006466)4.87274262
4Shallow orbits (HP:0000586)4.46166251
5Broad metatarsal (HP:0001783)4.46122962
6Atrophic scars (HP:0001075)4.39447958
7Aortic dissection (HP:0002647)4.28112674
8Cerebral aneurysm (HP:0004944)4.12965645
9Bladder diverticulum (HP:0000015)3.80083645
10Aortic aneurysm (HP:0004942)3.78836614
11Soft skin (HP:0000977)3.56766778
12Follicular hyperkeratosis (HP:0007502)3.31376452
13Fragile skin (HP:0001030)3.27066354
14Right ventricular cardiomyopathy (HP:0011663)3.10415811
15Increased connective tissue (HP:0009025)3.09099960
16Type 1 muscle fiber predominance (HP:0003803)3.04556660
17Mitral valve prolapse (HP:0001634)2.96843839
18Neonatal short-limb short stature (HP:0008921)2.96274567
19Dilatation of the ascending aorta (HP:0005111)2.94821802
20Cutaneous finger syndactyly (HP:0010554)2.92687654
21Peritonitis (HP:0002586)2.89790071
22Vitreoretinal degeneration (HP:0000655)2.87639321
23Abnormality of dentin (HP:0010299)2.84614933
24Cervical subluxation (HP:0003308)2.78374775
25Muscle fiber splitting (HP:0003555)2.78242162
26Partial duplication of thumb phalanx (HP:0009944)2.76963094
27Spinal rigidity (HP:0003306)2.74128899
28Sudden death (HP:0001699)2.73807961
29Aneurysm (HP:0002617)2.69701880
30Mesangial abnormality (HP:0001966)2.69047381
31Hypoplasia of the iris (HP:0007676)2.67569359
32Buphthalmos (HP:0000557)2.67072250
33Cutaneous syndactyly (HP:0012725)2.63738872
34Vascular tortuosity (HP:0004948)2.57375976
35Wrist flexion contracture (HP:0001239)2.56270390
36Wormian bones (HP:0002645)2.55702580
37Partial duplication of the phalanx of hand (HP:0009999)2.54033512
38Hyporeflexia of lower limbs (HP:0002600)2.52900415
39Increased variability in muscle fiber diameter (HP:0003557)2.51026568
40Blue sclerae (HP:0000592)2.50544952
41Ventricular tachycardia (HP:0004756)2.46390570
42Overgrowth (HP:0001548)2.44923149
43Asymmetry of the thorax (HP:0001555)2.41589521
44Preaxial foot polydactyly (HP:0001841)2.41399495
45Mildly elevated creatine phosphokinase (HP:0008180)2.38314480
46Abnormality of the ischium (HP:0003174)2.37122756
47Scapular winging (HP:0003691)2.35885198
48Hyperextensible skin (HP:0000974)2.35676130
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.35189568
50Genu recurvatum (HP:0002816)2.30290880
51Lipoatrophy (HP:0100578)2.30056875
52Bowel diverticulosis (HP:0005222)2.29875946
53Subacute progressive viral hepatitis (HP:0006572)2.26599700
54Lymphangioma (HP:0100764)2.26207716
55Midline defect of the nose (HP:0004122)2.24766026
56Arterial tortuosity (HP:0005116)2.22853255
57Pterygium (HP:0001059)2.19258280
58Broad thumb (HP:0011304)2.18039741
59Mitral regurgitation (HP:0001653)2.15129262
60Camptodactyly of toe (HP:0001836)2.13283574
61Thin bony cortex (HP:0002753)2.12644985
62Abnormality of skeletal muscle fiber size (HP:0012084)2.12240150
63Turricephaly (HP:0000262)2.11869917
64Trigonocephaly (HP:0000243)2.10617169
65Focal segmental glomerulosclerosis (HP:0000097)2.10316796
66Deviation of the hallux (HP:0010051)2.08934543
67Wide anterior fontanel (HP:0000260)2.08596486
68Abnormality of the calf musculature (HP:0001430)2.07847814
69Atrial fibrillation (HP:0005110)2.05721026
70Knee flexion contracture (HP:0006380)2.04540900
71Elbow flexion contracture (HP:0002987)2.04534638
72Short hallux (HP:0010109)2.03711951
73Coronal craniosynostosis (HP:0004440)2.03493998
74Missing ribs (HP:0000921)2.02579335
75Vertebral arch anomaly (HP:0008438)2.02100344
76Broad toe (HP:0001837)2.00444793
77Nuclear cataract (HP:0100018)1.99274064
78Broad ribs (HP:0000885)1.98423808
79Alacrima (HP:0000522)1.98356753
80Difficulty climbing stairs (HP:0003551)1.97836059
81Natal tooth (HP:0000695)1.97672506
82Osteolytic defects of the hand bones (HP:0009699)1.97242054
83Osteolytic defects of the phalanges of the hand (HP:0009771)1.97242054
84Abnormality of the calcaneus (HP:0008364)1.97108685
85Supraventricular arrhythmia (HP:0005115)1.97016086
86Hallux valgus (HP:0001822)1.97009048
87Ectopia lentis (HP:0001083)1.96463643
88Broad finger (HP:0001500)1.96450153
89Bifid tongue (HP:0010297)1.95839499
90Broad palm (HP:0001169)1.94922099
91Fragile nails (HP:0001808)1.94889501
92Subaortic stenosis (HP:0001682)1.94465319
93Abnormality of the left ventricular outflow tract (HP:0011103)1.94465319
94Limited hip movement (HP:0008800)1.94315572
95Joint laxity (HP:0001388)1.94293639
96Infantile muscular hypotonia (HP:0008947)1.94160008
97Rectal prolapse (HP:0002035)1.94044848
98Broad phalanges of the hand (HP:0009768)1.93692936
99Abnormality of the lacrimal duct (HP:0011481)1.92824715
100Synostosis of carpal bones (HP:0005048)1.92751455
101Hip contracture (HP:0003273)1.91988805
102Primary atrial arrhythmia (HP:0001692)1.91375935
103Milia (HP:0001056)1.91308200
104Limited elbow extension (HP:0001377)1.91218144
105Biconcave vertebral bodies (HP:0004586)1.89387607
106Vertebral clefting (HP:0008428)1.89021764
107Tracheomalacia (HP:0002779)1.88933328
108High anterior hairline (HP:0009890)1.88361055
109Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.88085601
110Vertebral hypoplasia (HP:0008417)1.88085601
111Broad phalanx (HP:0006009)1.87735867
112Hepatoblastoma (HP:0002884)1.87679008
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.87125652
114Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86717608
115Short 4th metacarpal (HP:0010044)1.86717608
116Myelomeningocele (HP:0002475)1.85326507
117Bronchomalacia (HP:0002780)1.85132451
118Mixed hearing impairment (HP:0000410)1.84677168
119Abnormality of cochlea (HP:0000375)1.83920042
120Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83227621
121Thin ribs (HP:0000883)1.82923991
122Pulmonary artery stenosis (HP:0004415)1.82475345
123Short nail (HP:0001799)1.82212159
124Mesomelia (HP:0003027)1.81962408
125Aplasia involving bones of the upper limbs (HP:0009823)1.81534776
126Aplasia of the phalanges of the hand (HP:0009802)1.81534776
127Aplasia involving bones of the extremities (HP:0009825)1.81534776
128Hypoplastic labia majora (HP:0000059)1.81517422
129Hypoplastic ischia (HP:0003175)1.81495760
130Congenital glaucoma (HP:0001087)1.81012487
131Esophageal atresia (HP:0002032)1.80966280
132Decreased lacrimation (HP:0000633)1.80321079
133Abnormality of the anterior chamber (HP:0000593)1.80188088
13411 pairs of ribs (HP:0000878)1.79571597
135Supraventricular tachycardia (HP:0004755)1.79229916
136Flat acetabular roof (HP:0003180)1.79196518
137Venous abnormality (HP:0002624)1.78938173
138Tibial bowing (HP:0002982)1.78641122
139Duplication of thumb phalanx (HP:0009942)1.77648153
140Abnormality of the nasolacrimal system (HP:0000614)1.77235675
141Long toe (HP:0010511)1.76717767
142Abnormality of the dental root (HP:0006486)1.76704424
143Taurodontia (HP:0000679)1.76704424
144Abnormality of permanent molar morphology (HP:0011071)1.76704424
145Renal duplication (HP:0000075)1.76290616
146Venous insufficiency (HP:0005293)1.75611414
147Broad hallux (HP:0010055)1.75258332
148Choanal stenosis (HP:0000452)1.74817813
149Abnormality of the 4th metacarpal (HP:0010012)1.74387497
150Omphalocele (HP:0001539)1.72664984
151Exostoses (HP:0100777)1.71924419
152Advanced eruption of teeth (HP:0006288)1.71070506
153Tarsal synostosis (HP:0008368)1.70979145
154Ulnar bowing (HP:0003031)1.70634361
155Broad long bones (HP:0005622)1.69888658
156Morphological abnormality of the middle ear (HP:0008609)1.69603557
157Abnormality of incisor morphology (HP:0011063)1.68936243
158Abnormality of molar (HP:0011077)1.67802881
159Abnormality of molar morphology (HP:0011070)1.67802881
160Anophthalmia (HP:0000528)1.64534645
161Abnormality of the pubic bones (HP:0003172)1.63489692
162Abnormality of the aortic arch (HP:0012303)1.63320551
163Renal hypoplasia (HP:0000089)1.62815133
164Split foot (HP:0001839)1.62752254
165Fibular hypoplasia (HP:0003038)1.60616695
166Abnormality of the middle phalanges of the toes (HP:0010183)1.58920701
167Abnormality of the labia majora (HP:0012881)1.58440952
168Hypoplastic pelvis (HP:0008839)1.57845567
169Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56608975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.63835097
2TRIB33.82655798
3PKN23.20733750
4DDR23.10114794
5EPHB22.97459399
6PDGFRA2.93396653
7PNCK2.70947810
8LATS12.66602130
9MYLK2.59204197
10EPHA42.37629812
11SIK12.31805524
12DMPK2.26869238
13PAK32.03496759
14RIPK12.03296856
15PAK22.01689496
16PTK61.93827610
17LMTK21.90117926
18FER1.88161716
19CAMK1G1.84970626
20CASK1.74442473
21PIK3CA1.69111722
22LATS21.66364198
23LRRK21.59381618
24ROCK11.57263474
25TGFBR21.56070248
26EPHA31.55948224
27TRPM71.55916851
28CAMK1D1.53144237
29PTK21.53025970
30PAK41.52800886
31TYRO31.50333558
32EPHA21.49625968
33MKNK11.46179795
34BMX1.32932684
35MAPK151.30814025
36WNK41.26845095
37BRD41.23044672
38CDK121.21802605
39STK38L1.20066191
40PDGFRB1.15028738
41ILK1.13633498
42ERN11.10946222
43MET1.10865156
44TIE11.09784586
45AKT31.09297446
46ROCK21.08075725
47WEE11.07032265
48FGFR11.06088702
49PBK1.01325899
50BCR0.97693146
51NTRK20.96961836
52EPHB10.95970388
53MTOR0.95738305
54STK30.92591405
55PRKD10.91980376
56PTK2B0.91276553
57FRK0.89651661
58MKNK20.87551934
59EEF2K0.85459901
60TESK10.85348569
61BRSK20.82851636
62CDC42BPA0.82290154
63STK100.81888793
64PDK30.81543813
65PDK40.81543813
66PHKG20.80955404
67PHKG10.80955404
68LIMK10.79723164
69FGFR20.78774284
70KSR10.77246284
71ERBB30.76290780
72NEK10.72881156
73MARK10.71865715
74OBSCN0.70251000
75DAPK30.70126789
76TTK0.70024032
77PDK20.69825738
78RET0.68484864
79TNIK0.64006047
80MAP2K10.63431207
81DYRK1B0.62129754
82WNK10.61706304
83NEK90.60626191
84MAPKAPK50.60316618
85MAP3K100.60163435
86SGK4940.60132681
87SGK2230.60132681
88NTRK10.60042442
89TSSK60.57343471
90STK390.57211205
91ERBB20.55978311
92MAP3K30.55847763
93RPS6KA20.55385252
94ZAK0.53443543
95PLK20.52810822
96MST1R0.50694751
97INSR0.49835628
98NEK20.49495270
99PRKCE0.49273234
100CDK60.49247108
101STK380.48211796
102PLK40.48207820
103ICK0.47555520
104SGK20.47319407
105MAP3K70.47176408
106PRKCH0.46950790
107SRC0.46336920
108FGFR30.46255172
109GSK3A0.45208565
110FLT30.44070831
111CDK30.43637777
112MAP3K20.43633340
113BRSK10.42525734
114MAP3K40.41525907
115SRPK10.40478528
116NEK60.40372733
117ERBB40.40314147
118STK240.40193363
119NTRK30.39968326
120MELK0.39438406
121PRKD20.38346011
122NUAK10.37963622
123RPS6KL10.37793500
124RPS6KC10.37793500
125PRKAA20.37491244
126FGFR40.36386290
127SGK30.36356549
128MARK20.36159811
129MAPK100.35998185
130TGFBR10.35975513
131RPS6KB20.35963176
132RPS6KB10.34801859
133MOS0.34586398
134IGF1R0.34319272
135SCYL20.33786867
136MAP2K20.33776458
137CAMK2D0.33586979
138PAK60.33316746
139PRKD30.33202065
140UHMK10.32176210
141ADRBK10.32114627

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045124.08969874
2* Focal adhesion_Homo sapiens_hsa045103.06958221
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.86001040
4Dilated cardiomyopathy_Homo sapiens_hsa054142.85894214
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.76589820
6Adherens junction_Homo sapiens_hsa045202.48664205
7Proteoglycans in cancer_Homo sapiens_hsa052052.38516847
8* Protein digestion and absorption_Homo sapiens_hsa049742.19147602
9* Amoebiasis_Homo sapiens_hsa051462.18953887
10* Small cell lung cancer_Homo sapiens_hsa052222.14738213
11Hippo signaling pathway_Homo sapiens_hsa043902.10406172
12Basal cell carcinoma_Homo sapiens_hsa052172.02825193
13* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.95733598
14Bladder cancer_Homo sapiens_hsa052191.91506874
15Tight junction_Homo sapiens_hsa045301.81203962
16Viral myocarditis_Homo sapiens_hsa054161.74258085
17Hedgehog signaling pathway_Homo sapiens_hsa043401.71365950
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67825378
19TGF-beta signaling pathway_Homo sapiens_hsa043501.67821126
20MicroRNAs in cancer_Homo sapiens_hsa052061.56819490
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.48937926
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40918639
23* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.33480261
24Steroid biosynthesis_Homo sapiens_hsa001001.32496195
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.32189082
26Axon guidance_Homo sapiens_hsa043601.24714558
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23833009
28Chronic myeloid leukemia_Homo sapiens_hsa052201.18026442
29Melanoma_Homo sapiens_hsa052181.16726896
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16064780
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15343613
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13438607
33* Pathways in cancer_Homo sapiens_hsa052001.09037053
34Melanogenesis_Homo sapiens_hsa049161.04951204
35Notch signaling pathway_Homo sapiens_hsa043301.03794272
36Prostate cancer_Homo sapiens_hsa052151.03755631
37Endometrial cancer_Homo sapiens_hsa052131.02963939
38Glioma_Homo sapiens_hsa052141.02535444
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01158208
40Pancreatic cancer_Homo sapiens_hsa052121.00402822
41Malaria_Homo sapiens_hsa051440.99544108
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.96796007
43Rap1 signaling pathway_Homo sapiens_hsa040150.96278952
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96052757
45Wnt signaling pathway_Homo sapiens_hsa043100.94594137
46Renal cell carcinoma_Homo sapiens_hsa052110.94279373
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91864788
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90432114
49Toxoplasmosis_Homo sapiens_hsa051450.88014265
50Platelet activation_Homo sapiens_hsa046110.87877676
51Insulin resistance_Homo sapiens_hsa049310.84027950
52Dorso-ventral axis formation_Homo sapiens_hsa043200.83821625
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82982250
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82969271
55Fatty acid metabolism_Homo sapiens_hsa012120.81619375
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.81416397
57Fatty acid degradation_Homo sapiens_hsa000710.80263960
58mTOR signaling pathway_Homo sapiens_hsa041500.78538023
59HTLV-I infection_Homo sapiens_hsa051660.77265231
60HIF-1 signaling pathway_Homo sapiens_hsa040660.76589816
61Cardiac muscle contraction_Homo sapiens_hsa042600.75978218
62Lysine degradation_Homo sapiens_hsa003100.75640649
63Ovarian steroidogenesis_Homo sapiens_hsa049130.70804992
64Prion diseases_Homo sapiens_hsa050200.70584015
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70150779
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68852796
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68132429
68Estrogen signaling pathway_Homo sapiens_hsa049150.68017802
69Gap junction_Homo sapiens_hsa045400.67353034
70N-Glycan biosynthesis_Homo sapiens_hsa005100.67308801
71Inositol phosphate metabolism_Homo sapiens_hsa005620.66680039
72Cell cycle_Homo sapiens_hsa041100.65153988
73Colorectal cancer_Homo sapiens_hsa052100.65130975
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64182087
75AMPK signaling pathway_Homo sapiens_hsa041520.64005808
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62868293
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62766504
78Biosynthesis of amino acids_Homo sapiens_hsa012300.60962698
79Thyroid hormone synthesis_Homo sapiens_hsa049180.60832749
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.60263647
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59619919
82Choline metabolism in cancer_Homo sapiens_hsa052310.59488627
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58981363
84Renin secretion_Homo sapiens_hsa049240.58806986
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58176989
86mRNA surveillance pathway_Homo sapiens_hsa030150.57669137
87Pyruvate metabolism_Homo sapiens_hsa006200.55969829
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55895169
89p53 signaling pathway_Homo sapiens_hsa041150.55539438
90VEGF signaling pathway_Homo sapiens_hsa043700.55502871
91Bile secretion_Homo sapiens_hsa049760.55149538
92PPAR signaling pathway_Homo sapiens_hsa033200.55137950
93Fatty acid biosynthesis_Homo sapiens_hsa000610.55132048
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54473480
95Nitrogen metabolism_Homo sapiens_hsa009100.54358008
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53193034
97Gastric acid secretion_Homo sapiens_hsa049710.52513535
98Arginine biosynthesis_Homo sapiens_hsa002200.51788552
99Insulin signaling pathway_Homo sapiens_hsa049100.51416140
100FoxO signaling pathway_Homo sapiens_hsa040680.51092511
101GnRH signaling pathway_Homo sapiens_hsa049120.49817191
102Renin-angiotensin system_Homo sapiens_hsa046140.49314234
103Complement and coagulation cascades_Homo sapiens_hsa046100.48801911
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48636259
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48256679
106Thyroid cancer_Homo sapiens_hsa052160.47899679
107Circadian rhythm_Homo sapiens_hsa047100.46714035
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.46495035
109Non-small cell lung cancer_Homo sapiens_hsa052230.46315498
110Cocaine addiction_Homo sapiens_hsa050300.45780248
111Propanoate metabolism_Homo sapiens_hsa006400.45570365
112Ras signaling pathway_Homo sapiens_hsa040140.45247056
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44423743
114cAMP signaling pathway_Homo sapiens_hsa040240.43909213
115Oxytocin signaling pathway_Homo sapiens_hsa049210.43847241
116Arginine and proline metabolism_Homo sapiens_hsa003300.43587746
117Endocytosis_Homo sapiens_hsa041440.42706925
118TNF signaling pathway_Homo sapiens_hsa046680.42466624
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41315462
120ErbB signaling pathway_Homo sapiens_hsa040120.41002451
121Glucagon signaling pathway_Homo sapiens_hsa049220.40617631
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40230113
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39975054
124Mineral absorption_Homo sapiens_hsa049780.38575056
125Oocyte meiosis_Homo sapiens_hsa041140.36535980
126ABC transporters_Homo sapiens_hsa020100.34320293
127Glutamatergic synapse_Homo sapiens_hsa047240.34067604
128Histidine metabolism_Homo sapiens_hsa003400.33900509
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32047678

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