COL5A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are thought to be responsible for the symptoms of a subset of patients with Ehlers-Danlos syndrome type III. Messages of several sizes can be detected in northern blots but sequence information cannot confirm the identity of the shorter messages. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.30461648
2negative regulation of erythrocyte differentiation (GO:0045647)6.60544009
3low-density lipoprotein particle clearance (GO:0034383)6.25364580
4short-chain fatty acid metabolic process (GO:0046459)5.74256939
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.46955373
6blood vessel maturation (GO:0001955)5.40429791
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.21002784
8positive regulation of fatty acid beta-oxidation (GO:0032000)5.12789791
9hyperosmotic salinity response (GO:0042538)5.08763120
10aggressive behavior (GO:0002118)5.08505103
11definitive hemopoiesis (GO:0060216)5.06248692
12regulation of sequestering of triglyceride (GO:0010889)5.04178024
13pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.99346395
14endothelium development (GO:0003158)4.85311561
15* collagen fibril organization (GO:0030199)4.79216290
16regulation of mast cell degranulation (GO:0043304)4.76761435
17positive regulation of fatty acid oxidation (GO:0046321)4.75123391
18regulation of mast cell activation involved in immune response (GO:0033006)4.74905207
19triglyceride catabolic process (GO:0019433)4.60558977
20regulation of female receptivity (GO:0045924)4.59383435
21positive regulation of mast cell degranulation (GO:0043306)4.51914798
22positive regulation of mast cell activation involved in immune response (GO:0033008)4.51914798
23pyrimidine nucleotide catabolic process (GO:0006244)4.36227170
24fatty acid transmembrane transport (GO:1902001)4.26925131
25neutral lipid catabolic process (GO:0046461)4.22424333
26acylglycerol catabolic process (GO:0046464)4.22424333
27regulation of fatty acid beta-oxidation (GO:0031998)4.22274665
28white fat cell differentiation (GO:0050872)4.12742468
29female mating behavior (GO:0060180)4.09302037
30regulation of penile erection (GO:0060405)4.03708552
31retina vasculature morphogenesis in camera-type eye (GO:0061299)3.97585836
32* collagen metabolic process (GO:0032963)3.97538227
33carnitine shuttle (GO:0006853)3.97319816
34brown fat cell differentiation (GO:0050873)3.95932087
35biotin metabolic process (GO:0006768)3.89937847
36regulation of cholesterol storage (GO:0010885)3.89469076
37* multicellular organismal macromolecule metabolic process (GO:0044259)3.88963811
38valine metabolic process (GO:0006573)3.85812506
39* collagen catabolic process (GO:0030574)3.84351515
40alpha-linolenic acid metabolic process (GO:0036109)3.79858113
41seminiferous tubule development (GO:0072520)3.79822687
42regulation of fatty acid oxidation (GO:0046320)3.78440407
43basement membrane organization (GO:0071711)3.76831314
44* multicellular organismal metabolic process (GO:0044236)3.75484073
45extracellular fibril organization (GO:0043206)3.74534244
46lipid particle organization (GO:0034389)3.72835053
47regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.65789604
48endodermal cell differentiation (GO:0035987)3.65172051
49adenosine receptor signaling pathway (GO:0001973)3.65022813
50skin morphogenesis (GO:0043589)3.63796533
51negative regulation of nitric oxide biosynthetic process (GO:0045019)3.61932318
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.61368110
53dermatan sulfate metabolic process (GO:0030205)3.57010819
54* multicellular organismal catabolic process (GO:0044243)3.54957136
55regulation of leukocyte degranulation (GO:0043300)3.54102081
56endocardial cushion development (GO:0003197)3.49836146
57fatty acid beta-oxidation (GO:0006635)3.49219444
58regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.48994447
59ethanol oxidation (GO:0006069)3.48656683
60negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.46188448
61negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.45203160
62positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.44919980
63positive regulation of lipid catabolic process (GO:0050996)3.43513122
64positive regulation of fatty acid metabolic process (GO:0045923)3.39968223
65lipopolysaccharide biosynthetic process (GO:0009103)3.38421824
66thrombin receptor signaling pathway (GO:0070493)3.35846122
67cellular response to vitamin (GO:0071295)3.34789781
68deoxyribonucleotide catabolic process (GO:0009264)3.32968413
69triglyceride biosynthetic process (GO:0019432)3.31980522
70granulocyte differentiation (GO:0030851)3.31496015
71positive regulation of leukocyte degranulation (GO:0043302)3.29782419
72plasma lipoprotein particle clearance (GO:0034381)3.29739070
73deoxyribose phosphate catabolic process (GO:0046386)3.28838703
74fibril organization (GO:0097435)3.28546527
75UV protection (GO:0009650)3.26013722
76vascular endothelial growth factor signaling pathway (GO:0038084)3.24523953
77acylglycerol biosynthetic process (GO:0046463)3.24043259
78neutral lipid biosynthetic process (GO:0046460)3.24043259
79acetyl-CoA metabolic process (GO:0006084)3.21160511
80positive regulation of mast cell activation (GO:0033005)3.20188507
81positive regulation of glycogen biosynthetic process (GO:0045725)3.19633912
82* extracellular matrix disassembly (GO:0022617)3.19160200
83relaxation of smooth muscle (GO:0044557)3.16497070
84ovulation from ovarian follicle (GO:0001542)3.16136878
85apoptotic cell clearance (GO:0043277)3.15242804
86fatty-acyl-CoA biosynthetic process (GO:0046949)3.14883696
87negative regulation of macrophage differentiation (GO:0045650)3.13785767
88dermatan sulfate biosynthetic process (GO:0030208)3.13738098
89complement activation, alternative pathway (GO:0006957)3.13674944
90positive regulation of cellular response to insulin stimulus (GO:1900078)3.13217725
91epoxygenase P450 pathway (GO:0019373)3.12921757
92regulation of inositol phosphate biosynthetic process (GO:0010919)3.12397662
93prostanoid biosynthetic process (GO:0046457)3.11129694
94prostaglandin biosynthetic process (GO:0001516)3.11129694
95fatty acid oxidation (GO:0019395)3.10136829
96glomerular filtration (GO:0003094)3.09666240
97positive regulation of endothelial cell apoptotic process (GO:2000353)3.09422844
98bone trabecula formation (GO:0060346)3.08490399
99triglyceride metabolic process (GO:0006641)3.05362798
100thioester biosynthetic process (GO:0035384)3.04125706
101acyl-CoA biosynthetic process (GO:0071616)3.04125706
102regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03599387
103lipid oxidation (GO:0034440)3.03419202
104regulation of mast cell activation (GO:0033003)3.03022487
105carnitine transmembrane transport (GO:1902603)3.02739742
106platelet aggregation (GO:0070527)3.02571156
107fatty acid catabolic process (GO:0009062)3.00248211
108purinergic receptor signaling pathway (GO:0035587)2.98475625
109pinocytosis (GO:0006907)2.94726184
110cellular hyperosmotic response (GO:0071474)2.93582275
111regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.92101196
112acylglycerol metabolic process (GO:0006639)2.91883237
113negative regulation of smooth muscle cell migration (GO:0014912)2.90872105
114regulation of erythrocyte differentiation (GO:0045646)2.90575939
115grooming behavior (GO:0007625)2.89932699
116long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.89917178
117regulation of glucose import in response to insulin stimulus (GO:2001273)2.89608285
118glycerolipid catabolic process (GO:0046503)2.87229430
119neutral lipid metabolic process (GO:0006638)2.86707583
120positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.86631333
121ethanol metabolic process (GO:0006067)2.86487552
122mature B cell differentiation involved in immune response (GO:0002313)2.85684257
123renal filtration (GO:0097205)2.85432032
124negative regulation of fatty acid transport (GO:2000192)2.84545459
125regulation of triglyceride catabolic process (GO:0010896)2.84432707
126prostaglandin metabolic process (GO:0006693)2.83912596
127prostanoid metabolic process (GO:0006692)2.83912596
128fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.83480830
129fatty-acyl-CoA metabolic process (GO:0035337)2.83184126
130cyclooxygenase pathway (GO:0019371)2.82258493
131negative regulation of smooth muscle cell proliferation (GO:0048662)2.81494789
132positive regulation of glycogen metabolic process (GO:0070875)2.81017658
133growth hormone receptor signaling pathway (GO:0060396)2.80707993
134negative regulation of protein autophosphorylation (GO:0031953)2.79850624
135L-serine transport (GO:0015825)2.79842167
136sequestering of extracellular ligand from receptor (GO:0035581)2.79809579
137hemoglobin metabolic process (GO:0020027)2.79117675
138fatty acid homeostasis (GO:0055089)2.79026931
139regulation of transmission of nerve impulse (GO:0051969)2.77358347
140positive regulation of fatty acid biosynthetic process (GO:0045723)2.76737521
141maternal behavior (GO:0042711)2.76429586
142amino-acid betaine transport (GO:0015838)2.76353283
143carnitine transport (GO:0015879)2.76353283
144positive regulation of lipid storage (GO:0010884)2.76350283
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76142443
146glial cell migration (GO:0008347)2.76016877
147extracellular matrix assembly (GO:0085029)2.74783602
148branched-chain amino acid metabolic process (GO:0009081)2.74346187
149positive regulation of glucose import (GO:0046326)2.74289315
150sulfur amino acid catabolic process (GO:0000098)2.73735055
151blood circulation (GO:0008015)2.73530757
152lipopolysaccharide metabolic process (GO:0008653)2.73208742
153positive regulation of macrophage cytokine production (GO:0060907)2.72576578
154regulation of complement activation (GO:0030449)2.72267142
155regulation of regulated secretory pathway (GO:1903305)2.71693734
156acylglycerol homeostasis (GO:0055090)2.70908046
157triglyceride homeostasis (GO:0070328)2.70908046
158regulation of plasminogen activation (GO:0010755)2.70444420
159facial nerve structural organization (GO:0021612)2.69471741
160negative regulation of granulocyte differentiation (GO:0030853)2.68197462
161cellular response to growth hormone stimulus (GO:0071378)2.67948553
162negative regulation of cartilage development (GO:0061037)2.67814957
163insulin-like growth factor receptor signaling pathway (GO:0048009)2.67532931
164response to dietary excess (GO:0002021)2.67429256
165regulation of triglyceride biosynthetic process (GO:0010866)2.65955022
166phagocytosis, engulfment (GO:0006911)2.65266986
167long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.65024683
168protein kinase C signaling (GO:0070528)2.64134075
169purinergic nucleotide receptor signaling pathway (GO:0035590)2.63047894
170regulation of protein activation cascade (GO:2000257)2.63012668
171positive regulation of triglyceride metabolic process (GO:0090208)2.62761820
172branched-chain amino acid catabolic process (GO:0009083)2.61965371
173glomerular basement membrane development (GO:0032836)2.61170991
174response to muramyl dipeptide (GO:0032495)2.60236331
175phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.59883919
176negative regulation of biomineral tissue development (GO:0070168)2.58979702
177keratan sulfate catabolic process (GO:0042340)2.58136483
178interkinetic nuclear migration (GO:0022027)2.57601610
179purine deoxyribonucleotide catabolic process (GO:0009155)2.56542730
180membrane invagination (GO:0010324)2.56067548
181defense response to protozoan (GO:0042832)2.55144914
182response to misfolded protein (GO:0051788)2.55015658
183negative regulation of bone mineralization (GO:0030502)2.49897135
184positive regulation of natural killer cell differentiation (GO:0032825)2.47481930
185regulation of hydrogen peroxide metabolic process (GO:0010310)2.45818616
186misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.45455195
187stress fiber assembly (GO:0043149)2.44683390
188positive regulation of regulated secretory pathway (GO:1903307)2.43401829
189regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.42320890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.13792490
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.68091840
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.82740524
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.37047012
5* CLOCK_20551151_ChIP-Seq_293T_Human3.95483217
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.90126832
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.89464090
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.75522243
9SCL_19346495_ChIP-Seq_HPC-7_Human3.73188729
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.53821398
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.19441565
12RXR_22158963_ChIP-Seq_LIVER_Mouse3.16242610
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.93364382
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.82949056
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.73043846
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.68985704
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.51216039
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.42998471
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32998162
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28128325
21ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.27996177
22GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.24734487
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.22151265
24* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21508555
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10364137
26* ELF1_20517297_ChIP-Seq_JURKAT_Human1.95277170
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.94843315
28BCL6_27268052_Chip-Seq_Bcells_Human1.81991254
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81674213
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.80993124
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80202485
32CJUN_26792858_Chip-Seq_BT549_Human1.80063875
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75660498
34P68_20966046_ChIP-Seq_HELA_Human1.73200482
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72730694
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67998941
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.67946315
38VDR_21846776_ChIP-Seq_THP-1_Human1.67413722
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.65783182
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59240007
41* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58645293
42SMC3_22415368_ChIP-Seq_MEFs_Mouse1.58166943
43BCOR_27268052_Chip-Seq_Bcells_Human1.54305817
44* TET1_21451524_ChIP-Seq_MESCs_Mouse1.51550303
45PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.50765696
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47550519
47CTCF_27219007_Chip-Seq_Bcells_Human1.47429206
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.46464444
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.46464444
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45933280
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45789559
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.45598806
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.42217868
54* GATA1_19941827_ChIP-Seq_MEL_Mouse1.40047589
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38693581
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38237434
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36989731
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.36797092
59CTCF_26484167_Chip-Seq_Bcells_Mouse1.34990723
60ZNF263_19887448_ChIP-Seq_K562_Human1.33293705
61* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.32360887
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32264273
63SA1_22415368_ChIP-Seq_MEFs_Mouse1.31656209
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30286560
65P300_27268052_Chip-Seq_Bcells_Human1.29802987
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28075711
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27504926
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27099100
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26581219
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23953985
71* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23893780
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23126980
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22531499
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21963071
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21447835
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20552263
77VDR_24763502_ChIP-Seq_THP-1_Human1.20529369
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20240799
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19370148
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19370148
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17278727
82LXR_22292898_ChIP-Seq_THP-1_Human1.16983374
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.16891442
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.16368150
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16195097
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15701524
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15043629
88BRD4_25478319_ChIP-Seq_HGPS_Human1.14992754
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.14899765
90CTCF_21964334_Chip-Seq_Bcells_Human1.14305831
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14065248
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13392513
93E2F1_20622854_ChIP-Seq_HELA_Human1.11592067
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09808112
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.08824880
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08053812
97RACK7_27058665_Chip-Seq_MCF-7_Human1.07743779
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05953714
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05925494
100KDM2B_26808549_Chip-Seq_K562_Human1.05473355
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.05245390
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.05074103
103PHF8_20622854_ChIP-Seq_HELA_Human1.04999504
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04605151
105UTX_26944678_Chip-Seq_JUKART_Human1.04325887
106EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04063706
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03934983
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03657989
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03475537
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.02575048
111SA1_27219007_Chip-Seq_Bcells_Human1.02474137
112SMC4_20622854_ChIP-Seq_HELA_Human1.01950952
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01463653
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00977192
115P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00057379
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99573935
117EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98614794
118RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98614794
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97310599
120CTCF_20526341_ChIP-Seq_ESCs_Human0.96320297
121SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95033001
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94976811
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94694686
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94677688
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94523023
126TCF7_22412390_ChIP-Seq_EML_Mouse0.94110986
127SPI1_20517297_ChIP-Seq_HL60_Human0.93628095
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92965706
129SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92921213
130* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92647456
131MAF_26560356_Chip-Seq_TH1_Human0.91869388
132NCOR1_26117541_ChIP-Seq_K562_Human0.91641877
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91330967
134STAT1_20625510_ChIP-Seq_HELA_Human0.90721389
135ATF3_27146783_Chip-Seq_COLON_Human0.90294717
136JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89892128
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.89551872
138* TP63_22573176_ChIP-Seq_HFKS_Human0.89154897
139TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88783329
140KDM2B_26808549_Chip-Seq_DND41_Human0.88007100
141MAF_26560356_Chip-Seq_TH2_Human0.87985157
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87921672
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87372015
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87324834
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87324834
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86974911
147NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86517871
148SOX2_20726797_ChIP-Seq_SW620_Human0.86385547
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85759538
150SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85261505
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83513794
152TP53_22127205_ChIP-Seq_IMR90_Human0.83155778
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82335869
154ISL1_27105846_Chip-Seq_CPCs_Mouse0.81926154
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81458888
156ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81193825
157UBF1/2_26484160_Chip-Seq_HMECs_Human0.80492733
158DROSHA_22980978_ChIP-Seq_HELA_Human0.80421123
159VDR_24787735_ChIP-Seq_THP-1_Human0.80169189
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79702452
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79075199
162KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77847764
163* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77494895
164RUNX1_27514584_Chip-Seq_MCF-7_Human0.77130335
165FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77106844
166SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76016326
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.75959982
168GATA1_19941826_ChIP-Seq_K562_Human0.75598663
169GATA1_22025678_ChIP-Seq_K562_Human0.75535917
170Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75424891
171KDM2B_26808549_Chip-Seq_JURKAT_Human0.73247687
172TP53_20018659_ChIP-ChIP_R1E_Mouse0.72654671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.28450793
2MP0005275_abnormal_skin_tensile5.44822021
3MP0005670_abnormal_white_adipose4.42571308
4MP0003705_abnormal_hypodermis_morpholog3.85204838
5MP0005503_abnormal_tendon_morphology3.57294901
6MP0000465_gastrointestinal_hemorrhage3.51289134
7MP0004272_abnormal_basement_membrane3.37871328
8MP0005397_hematopoietic_system_phenotyp3.26391187
9MP0001545_abnormal_hematopoietic_system3.26391187
10MP0003279_aneurysm3.03152375
11MP0005666_abnormal_adipose_tissue3.02474164
12MP0004130_abnormal_muscle_cell2.67895748
13MP0004185_abnormal_adipocyte_glucose2.58650578
14MP0009278_abnormal_bone_marrow2.57728792
15MP0000751_myopathy2.57682015
16MP0000013_abnormal_adipose_tissue2.56597236
17MP0005375_adipose_tissue_phenotype2.48657470
18MP0002060_abnormal_skin_morphology2.28009379
19MP0002837_dystrophic_cardiac_calcinosis2.25255443
20MP0001958_emphysema2.21075929
21MP0005464_abnormal_platelet_physiology2.12861509
22MP0000003_abnormal_adipose_tissue2.04650458
23MP0008004_abnormal_stomach_pH1.85582696
24MP0002108_abnormal_muscle_morphology1.80196093
25MP0010329_abnormal_lipoprotein_level1.77248882
26MP0002971_abnormal_brown_adipose1.64795410
27MP0005257_abnormal_intraocular_pressure1.63089096
28MP0003566_abnormal_cell_adhesion1.61639392
29MP0006054_spinal_hemorrhage1.58674044
30MP0000750_abnormal_muscle_regeneration1.58318372
31MP0002148_abnormal_hypersensitivity_rea1.58239760
32MP0009115_abnormal_fat_cell1.55444500
33MP0001661_extended_life_span1.52861189
34MP0003191_abnormal_cellular_cholesterol1.52819495
35MP0005165_increased_susceptibility_to1.50522543
36MP0002139_abnormal_hepatobiliary_system1.42867647
37MP0003806_abnormal_nucleotide_metabolis1.40104582
38MP0006036_abnormal_mitochondrial_physio1.39613243
39MP0003045_fibrosis1.39573873
40MP0005623_abnormal_meninges_morphology1.34049410
41MP0000230_abnormal_systemic_arterial1.33797615
42MP0005365_abnormal_bile_salt1.33253491
43MP0006276_abnormal_autonomic_nervous1.33037641
44MP0005167_abnormal_blood-brain_barrier1.32552819
45MP0009379_abnormal_foot_pigmentation1.32331408
46MP0005334_abnormal_fat_pad1.28998200
47MP0002295_abnormal_pulmonary_circulatio1.28648401
48MP0001851_eye_inflammation1.27766784
49MP0003303_peritoneal_inflammation1.27542771
50MP0001243_abnormal_dermal_layer1.26344010
51MP0005508_abnormal_skeleton_morphology1.25253912
52MP0003172_abnormal_lysosome_physiology1.22341656
53MP0005360_urolithiasis1.18503429
54MP0004087_abnormal_muscle_fiber1.18254121
55MP0000749_muscle_degeneration1.17437467
56MP0005645_abnormal_hypothalamus_physiol1.17128655
57MP0002118_abnormal_lipid_homeostasis1.16564509
58MP0003436_decreased_susceptibility_to1.16496427
59MP0009384_cardiac_valve_regurgitation1.14440923
60MP0002970_abnormal_white_adipose1.13697773
61MP0003091_abnormal_cell_migration1.10055504
62MP0005023_abnormal_wound_healing1.09709867
63MP0000759_abnormal_skeletal_muscle1.07588399
64MP0003075_altered_response_to1.07431912
65MP0002168_other_aberrant_phenotype1.07091038
66MP0000681_abnormal_thyroid_gland1.05746767
67MP0002166_altered_tumor_susceptibility1.04964250
68MP0000733_abnormal_muscle_development1.03632308
69MP0002282_abnormal_trachea_morphology1.03392478
70MP0001542_abnormal_bone_strength1.00652994
71MP0003186_abnormal_redox_activity0.99558666
72MP0003959_abnormal_lean_body0.98551643
73MP0002132_abnormal_respiratory_system0.98030387
74MP0005646_abnormal_pituitary_gland0.96142874
75MP0008775_abnormal_heart_ventricle0.93592657
76MP0009697_abnormal_copulation0.92478812
77MP0002396_abnormal_hematopoietic_system0.92352501
78MP0002896_abnormal_bone_mineralization0.91790224
79MP0006138_congestive_heart_failure0.91511138
80MP0002876_abnormal_thyroid_physiology0.91357448
81MP0002006_tumorigenesis0.89349063
82MP0005330_cardiomyopathy0.89265295
83MP0002733_abnormal_thermal_nociception0.89233643
84MP0000609_abnormal_liver_physiology0.88845183
85MP0005164_abnormal_response_to0.88190219
86MP0000767_abnormal_smooth_muscle0.87061136
87MP0003252_abnormal_bile_duct0.87025315
88MP0001881_abnormal_mammary_gland0.86514631
89MP0002735_abnormal_chemical_nociception0.85479550
90MP0005058_abnormal_lysosome_morphology0.85396144
91MP0000747_muscle_weakness0.84626078
92MP0005620_abnormal_muscle_contractility0.84393153
93MP0003385_abnormal_body_wall0.83228271
94MP0002653_abnormal_ependyma_morphology0.81218571
95MP0003950_abnormal_plasma_membrane0.79943144
96MP0005451_abnormal_body_composition0.79549729
97MP0005369_muscle_phenotype0.78936124
98MP0001873_stomach_inflammation0.78883096
99MP0000372_irregular_coat_pigmentation0.78291016
100MP0009763_increased_sensitivity_to0.77469671
101MP0005385_cardiovascular_system_phenoty0.77137292
102MP0001544_abnormal_cardiovascular_syste0.77137292
103MP0004808_abnormal_hematopoietic_stem0.76260296
104MP0005390_skeleton_phenotype0.75740663
105MP0002796_impaired_skin_barrier0.75239599
106MP0002254_reproductive_system_inflammat0.75233752
107MP0005595_abnormal_vascular_smooth0.75196316
108MP0002269_muscular_atrophy0.74592641
109MP0008789_abnormal_olfactory_epithelium0.74059003
110MP0009780_abnormal_chondrocyte_physiolo0.73954689
111MP0005448_abnormal_energy_balance0.73901500
112MP0000343_altered_response_to0.73120473
113MP0001835_abnormal_antigen_presentation0.72682369
114MP0004134_abnormal_chest_morphology0.72504001
115MP0000249_abnormal_blood_vessel0.71345123
116MP0001879_abnormal_lymphatic_vessel0.70200653
117MP0002998_abnormal_bone_remodeling0.69916732
118MP0002106_abnormal_muscle_physiology0.68844286
119MP0004036_abnormal_muscle_relaxation0.68458250
120MP0004859_abnormal_synaptic_plasticity0.67811810
121MP0004084_abnormal_cardiac_muscle0.67498441
122MP0010630_abnormal_cardiac_muscle0.65707609
123MP0000163_abnormal_cartilage_morphology0.65665512
124MP0008874_decreased_physiological_sensi0.65486895
125MP0005171_absent_coat_pigmentation0.64902531
126MP0003690_abnormal_glial_cell0.64547281
127MP0010771_integument_phenotype0.64474227
128MP0010352_gastrointestinal_tract_polyps0.64328926
129MP0003724_increased_susceptibility_to0.63957031
130MP0001853_heart_inflammation0.63857558
131MP0002128_abnormal_blood_circulation0.63747039
132MP0002933_joint_inflammation0.63439471
133MP0005319_abnormal_enzyme/_coenzyme0.63414072
134MP0005076_abnormal_cell_differentiation0.62627258
135MP0001533_abnormal_skeleton_physiology0.62295474
136MP0001299_abnormal_eye_distance/0.62017930
137MP0004858_abnormal_nervous_system0.61790227
138MP0005410_abnormal_fertilization0.61660661
139MP0002398_abnormal_bone_marrow0.61599180
140MP0003638_abnormal_response/metabolism_0.61532088
141MP0005025_abnormal_response_to0.61052451
142MP0005085_abnormal_gallbladder_physiolo0.60691364
143MP0005535_abnormal_body_temperature0.60285616
144MP0002419_abnormal_innate_immunity0.59807201
145MP0008569_lethality_at_weaning0.59554857
146MP0010368_abnormal_lymphatic_system0.59512751
147MP0003763_abnormal_thymus_physiology0.59286664
148MP0002115_abnormal_skeleton_extremities0.59278958
149MP0005452_abnormal_adipose_tissue0.59208246
150MP0005166_decreased_susceptibility_to0.59061806
151MP0001614_abnormal_blood_vessel0.59058303
152MP0003828_pulmonary_edema0.56723652
153MP0001756_abnormal_urination0.56634013
154MP0009250_abnormal_appendicular_skeleto0.56519513

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.02812348
2Premature rupture of membranes (HP:0001788)6.90247480
3Ankle contracture (HP:0006466)6.05476240
4Type 1 muscle fiber predominance (HP:0003803)5.44026264
5Increased connective tissue (HP:0009025)5.33035245
6Aortic dissection (HP:0002647)4.83342556
7Follicular hyperkeratosis (HP:0007502)4.74504744
8Broad metatarsal (HP:0001783)4.69416455
9Cerebral aneurysm (HP:0004944)4.45679048
10Exercise-induced myalgia (HP:0003738)4.38153347
11Soft skin (HP:0000977)4.35583995
12Atrophic scars (HP:0001075)4.31366486
13Slender build (HP:0001533)4.24841658
14Peritonitis (HP:0002586)4.14818957
15Spinal rigidity (HP:0003306)4.04838713
16Increased variability in muscle fiber diameter (HP:0003557)4.04106231
17Abnormal pupillary function (HP:0007686)4.03243732
18Fragile skin (HP:0001030)3.97713421
19Distal arthrogryposis (HP:0005684)3.68379408
20Shallow orbits (HP:0000586)3.66342395
21Dilatation of the ascending aorta (HP:0005111)3.63286205
22Mitral valve prolapse (HP:0001634)3.61115456
23Abnormality of skeletal muscle fiber size (HP:0012084)3.50948514
24Bladder diverticulum (HP:0000015)3.44916181
25Hypertensive crisis (HP:0100735)3.39214555
26Petechiae (HP:0000967)3.39007523
27Muscle fiber splitting (HP:0003555)3.38086769
28Mildly elevated creatine phosphokinase (HP:0008180)3.35743956
29Aortic aneurysm (HP:0004942)3.32319700
30Abnormality of the heme biosynthetic pathway (HP:0010472)3.28647269
31Acanthosis nigricans (HP:0000956)3.10464324
32Prolonged bleeding time (HP:0003010)3.09500274
33Areflexia of lower limbs (HP:0002522)3.01083931
34Muscle stiffness (HP:0003552)2.99647251
35Episodic fever (HP:0001954)2.96421999
36Striae distensae (HP:0001065)2.90098400
37Genu recurvatum (HP:0002816)2.85501142
38Epistaxis (HP:0000421)2.77814841
39Blue sclerae (HP:0000592)2.76741581
40Oligomenorrhea (HP:0000876)2.75506777
41Purpura (HP:0000979)2.73963896
42Venous abnormality (HP:0002624)2.72928481
43Venous insufficiency (HP:0005293)2.71373987
44Neonatal short-limb short stature (HP:0008921)2.71238942
45Increased mean platelet volume (HP:0011877)2.70672186
46Difficulty running (HP:0009046)2.69055517
47Joint stiffness (HP:0001387)2.65619686
48Infantile muscular hypotonia (HP:0008947)2.64551402
49Hyperextensible skin (HP:0000974)2.63539489
50Ectopia lentis (HP:0001083)2.59966208
51Gingival bleeding (HP:0000225)2.58270095
52Visual hallucinations (HP:0002367)2.57106934
53Wormian bones (HP:0002645)2.56736488
54Thrombocytosis (HP:0001894)2.56528384
55Biconcave vertebral bodies (HP:0004586)2.50738095
56Abnormal platelet volume (HP:0011876)2.50429652
57Aneurysm (HP:0002617)2.48898747
58Round ear (HP:0100830)2.47409972
59Wrist flexion contracture (HP:0001239)2.47226512
60Abnormality of dentin (HP:0010299)2.47152788
61Cellulitis (HP:0100658)2.46473072
62Rhabdomyolysis (HP:0003201)2.45429707
63Hypertriglyceridemia (HP:0002155)2.43895727
64Increased muscle lipid content (HP:0009058)2.42288731
65Myocardial infarction (HP:0001658)2.41472201
66Elevated erythrocyte sedimentation rate (HP:0003565)2.41234692
67Cervical subluxation (HP:0003308)2.38650456
68Osteolytic defects of the hand bones (HP:0009699)2.37226074
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.37226074
70Abnormality of iron homeostasis (HP:0011031)2.36146846
71Mitral stenosis (HP:0001718)2.35785897
72Generalized amyotrophy (HP:0003700)2.33878448
73Complement deficiency (HP:0004431)2.33105730
74Bone cyst (HP:0012062)2.31248917
75Xanthomatosis (HP:0000991)2.26090090
76Abnormal delivery (HP:0001787)2.25949169
77Redundant skin (HP:0001582)2.23483537
78Hyperthyroidism (HP:0000836)2.22360298
79Hyporeflexia of lower limbs (HP:0002600)2.22278689
80Joint laxity (HP:0001388)2.21463433
81Breech presentation (HP:0001623)2.21019737
82Hypoalphalipoproteinemia (HP:0003233)2.20315238
83Stomatitis (HP:0010280)2.19247276
84Alopecia of scalp (HP:0002293)2.18013657
85Elbow flexion contracture (HP:0002987)2.16916250
86Bowel diverticulosis (HP:0005222)2.16057074
87Increased intramyocellular lipid droplets (HP:0012240)2.14447132
88Systemic lupus erythematosus (HP:0002725)2.13391861
89Bruising susceptibility (HP:0000978)2.12981819
90Osteoarthritis (HP:0002758)2.11355772
91Vertebral compression fractures (HP:0002953)2.11129283
92Increased serum ferritin (HP:0003281)2.10641618
93Menorrhagia (HP:0000132)2.08867381
94Enlarged penis (HP:0000040)2.08106406
95Overgrowth (HP:0001548)2.06563807
96Renal Fanconi syndrome (HP:0001994)2.05330536
97Vascular tortuosity (HP:0004948)2.04405082
98Atelectasis (HP:0100750)2.03654915
99Abnormality of transition element cation homeostasis (HP:0011030)2.03318535
100Limb-girdle muscle weakness (HP:0003325)2.03255892
101Skin nodule (HP:0200036)2.03181702
102Easy fatigability (HP:0003388)2.02424345
103Hyperglycinuria (HP:0003108)2.00950790
104Abnormality of the tricuspid valve (HP:0001702)1.99536255
105Lipoatrophy (HP:0100578)1.98793822
106Turricephaly (HP:0000262)1.98029769
107Centrally nucleated skeletal muscle fibers (HP:0003687)1.96128537
108Right ventricular cardiomyopathy (HP:0011663)1.96024465
109Congenital hip dislocation (HP:0001374)1.94566434
110Autoimmune hemolytic anemia (HP:0001890)1.93729140
111Nonimmune hydrops fetalis (HP:0001790)1.92734075
112Focal motor seizures (HP:0011153)1.90818455
113Hemorrhage of the eye (HP:0011885)1.90681934
114Hypoventilation (HP:0002791)1.90124595
115J-shaped sella turcica (HP:0002680)1.88987600
116Aortic regurgitation (HP:0001659)1.88742590
117Ragged-red muscle fibers (HP:0003200)1.87556150
118Urinary glycosaminoglycan excretion (HP:0003541)1.87493041
119Mucopolysacchariduria (HP:0008155)1.87493041
120Hypoplasia of the iris (HP:0007676)1.86720682
121Abnormality of complement system (HP:0005339)1.86530062
122Hepatosplenomegaly (HP:0001433)1.86047883
123Difficulty climbing stairs (HP:0003551)1.84880317
124Myoglobinuria (HP:0002913)1.84002154
125Thin bony cortex (HP:0002753)1.83997000
126Abnormality of polysaccharide metabolism (HP:0011012)1.83890724
127Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83890724
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83890724
129Flexion contracture of toe (HP:0005830)1.81963937
130Joint contractures involving the joints of the feet (HP:0100492)1.81963937
131Back pain (HP:0003418)1.81593129
132Wide anterior fontanel (HP:0000260)1.80885136
133Pulmonary artery stenosis (HP:0004415)1.80857038
134Deep venous thrombosis (HP:0002625)1.80669105
135Spondylolisthesis (HP:0003302)1.79366851
136Thin skin (HP:0000963)1.78261284
137Dysostosis multiplex (HP:0000943)1.76952646
138Trismus (HP:0000211)1.75806525
139Pulmonary hypertension (HP:0002092)1.75701890
140Epidermoid cyst (HP:0200040)1.75646539
141Tibial bowing (HP:0002982)1.75476684
142Camptodactyly of toe (HP:0001836)1.74954744
143Lymphangioma (HP:0100764)1.74539158
144Hydroxyprolinuria (HP:0003080)1.74224233
145Abnormality of proline metabolism (HP:0010907)1.74224233
146Obstructive lung disease (HP:0006536)1.73779377
147Insulin-resistant diabetes mellitus (HP:0000831)1.73599224
148Abnormality of the acetabulum (HP:0003170)1.72990477
149Ulnar bowing (HP:0003031)1.72571604
150Achilles tendon contracture (HP:0001771)1.70159549
151Abnormality of the Achilles tendon (HP:0005109)1.69898396
152Abnormality of the peritoneum (HP:0002585)1.69026785
153Hyperlipoproteinemia (HP:0010980)1.68285625
154Deviation of the hallux (HP:0010051)1.67592335
155Mitral regurgitation (HP:0001653)1.67483746
156Buphthalmos (HP:0000557)1.67024001
157Abnormality of serine family amino acid metabolism (HP:0010894)1.66816149
158Abnormality of glycine metabolism (HP:0010895)1.66816149
159Gingival overgrowth (HP:0000212)1.63561785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.34481639
2SIK14.25999467
3CAMK1D3.75850426
4ERN13.57302434
5PDGFRA3.41471934
6MAP3K113.38519352
7TTN3.25589417
8CAMK1G2.80543512
9DDR22.71303493
10VRK22.62395043
11RIPK12.40187721
12PIM22.35976357
13BCKDK2.34455838
14SCYL22.18528718
15PKN22.08371331
16KDR2.07194024
17TESK11.98741434
18TBK11.97096126
19MAP3K101.92298325
20TAOK21.91640640
21FGFR41.90582216
22NME21.86547895
23MAP3K11.83621015
24PRPF4B1.81487762
25FES1.81268289
26CCNB11.63831676
27LATS11.58646943
28MYLK1.58355168
29LATS21.56527269
30JAK31.51388563
31PBK1.48065757
32MST1R1.46647738
33PDK41.45501155
34PDK31.45501155
35MAP3K121.44824084
36EPHB21.40252450
37TESK21.40108502
38TGFBR21.37764966
39PAK21.37141436
40LMTK21.31890703
41BMX1.31691862
42FGFR21.29983356
43EPHB11.25691338
44PDGFRB1.23139817
45MAP2K11.23073931
46FER1.22233011
47FGFR31.21744812
48EPHA31.17032737
49MET1.15571109
50INSRR1.14664957
51FRK1.13077353
52MAP4K21.13002598
53PTK61.12602456
54PRKAA21.11306098
55PKN11.10942794
56DAPK11.02952965
57TEC1.01080371
58PIK3CA0.98953693
59LIMK10.97555888
60CAMK10.97248885
61MTOR0.96599348
62DMPK0.96422632
63JAK10.95217060
64GRK60.95137389
65PIK3CG0.92107165
66ZAP700.92010675
67MAP4K10.91727782
68CDK60.90692418
69OBSCN0.90602801
70KIT0.90498839
71GRK50.89891984
72RET0.89091470
73ICK0.87044376
74PDK20.86275793
75TRPM70.84438007
76PTK2B0.83487939
77SYK0.83120110
78ARAF0.80579776
79PTK20.80098717
80NEK90.79056927
81MOS0.78874431
82PRKD10.78551491
83TAOK30.78103878
84FGFR10.77123326
85TYK20.76125816
86DAPK20.75170035
87BTK0.75126311
88ILK0.75125989
89LRRK20.73635397
90TNK20.73507338
91CAMK2G0.72152575
92NTRK10.72002158
93MAP3K50.71292821
94ROCK10.69580974
95PHKG20.69419940
96PHKG10.69419940
97MAP2K60.68557483
98ABL20.67615932
99PAK30.67514801
100PRKCH0.66789010
101MAP3K70.62098442
102INSR0.61586720
103PRKAA10.60449029
104DYRK1B0.60195783
105IKBKB0.58201312
106GSK3A0.57281513
107MAPK30.56923141
108MAP2K40.56375605
109STK380.55988677
110FLT30.55372545
111STK30.55161447
112CAMK2B0.54967559
113TIE10.54636145
114MATK0.53979641
115CSK0.53247973
116MAP2K20.52967931
117MAP2K30.52711947
118ERBB40.51626059
119ITK0.51522322
120EEF2K0.50839568
121DAPK30.48783486
122PRKD20.48437315
123MAPK110.48408517
124CDK90.48147313
125MAPKAPK30.48146316
126GRK70.47766675
127PAK60.47667502
128MAP3K30.44920298
129RAF10.44833772
130CAMK2D0.44703967
131PRKD30.44260760
132MARK20.41263583
133PRKCD0.41155188
134MAP2K70.40926594
135JAK20.40749347
136SRC0.40552748
137PAK40.40224995
138PDPK10.40180521
139IRAK30.39768306
140CDC42BPA0.39072313
141IGF1R0.38486417
142PRKCQ0.36952236
143ROCK20.36633626
144MAPK120.35918735
145PRKCA0.35557019
146ABL10.32079597
147PRKACA0.31173480
148MAPK100.31101015
149CSF1R0.30963405
150PRKG20.30892242
151PRKACG0.30241780
152VRK10.30205130
153MAP3K60.27590626
154ADRBK10.27092287
155MAPK40.25159256
156EPHA20.23553602

Predicted pathways (KEGG)

RankGene SetZ-score
1PPAR signaling pathway_Homo sapiens_hsa033203.43323522
2ECM-receptor interaction_Homo sapiens_hsa045123.27290481
3Fatty acid biosynthesis_Homo sapiens_hsa000613.27028271
4Propanoate metabolism_Homo sapiens_hsa006402.93163548
5Asthma_Homo sapiens_hsa053102.85939985
6Fatty acid metabolism_Homo sapiens_hsa012122.79174302
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.69527645
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.63806483
9Fatty acid degradation_Homo sapiens_hsa000712.60625784
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55372069
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.34561586
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.27203804
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10665898
14* Protein digestion and absorption_Homo sapiens_hsa049742.00027059
15Focal adhesion_Homo sapiens_hsa045101.97126373
16Nitrogen metabolism_Homo sapiens_hsa009101.91504663
17Glycerolipid metabolism_Homo sapiens_hsa005611.80202375
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.77292927
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.74619196
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.73652919
21Hematopoietic cell lineage_Homo sapiens_hsa046401.65038543
22Caffeine metabolism_Homo sapiens_hsa002321.62252107
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59403297
24Pyruvate metabolism_Homo sapiens_hsa006201.58902100
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53898961
26AMPK signaling pathway_Homo sapiens_hsa041521.51317841
27Other glycan degradation_Homo sapiens_hsa005111.48241487
28Allograft rejection_Homo sapiens_hsa053301.47139614
29Complement and coagulation cascades_Homo sapiens_hsa046101.46627891
30Amoebiasis_Homo sapiens_hsa051461.46182944
31Calcium signaling pathway_Homo sapiens_hsa040201.45796418
32Tryptophan metabolism_Homo sapiens_hsa003801.45724172
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.45161429
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41951148
35beta-Alanine metabolism_Homo sapiens_hsa004101.39782308
36Phenylalanine metabolism_Homo sapiens_hsa003601.33767524
37Insulin resistance_Homo sapiens_hsa049311.33439795
38Fat digestion and absorption_Homo sapiens_hsa049751.32158540
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30635302
40Arachidonic acid metabolism_Homo sapiens_hsa005901.28740965
41Tyrosine metabolism_Homo sapiens_hsa003501.27927701
42Arginine biosynthesis_Homo sapiens_hsa002201.24461896
43Carbon metabolism_Homo sapiens_hsa012001.23866670
44Renin-angiotensin system_Homo sapiens_hsa046141.22141435
45Peroxisome_Homo sapiens_hsa041461.20458953
46Leishmaniasis_Homo sapiens_hsa051401.18084517
47Autoimmune thyroid disease_Homo sapiens_hsa053201.17900263
48Pertussis_Homo sapiens_hsa051331.15951997
49Primary immunodeficiency_Homo sapiens_hsa053401.14979751
50Selenocompound metabolism_Homo sapiens_hsa004501.14933967
51Butanoate metabolism_Homo sapiens_hsa006501.13599723
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13079319
53Lysosome_Homo sapiens_hsa041421.12739283
54Olfactory transduction_Homo sapiens_hsa047401.07889734
55Dilated cardiomyopathy_Homo sapiens_hsa054141.07180475
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03803376
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02714443
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02377962
59Small cell lung cancer_Homo sapiens_hsa052221.01818169
60Insulin signaling pathway_Homo sapiens_hsa049101.00779189
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00605802
62Graft-versus-host disease_Homo sapiens_hsa053320.99788698
63Proteoglycans in cancer_Homo sapiens_hsa052050.97145970
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95646316
65Type I diabetes mellitus_Homo sapiens_hsa049400.95555425
66Salivary secretion_Homo sapiens_hsa049700.94277557
67Ovarian steroidogenesis_Homo sapiens_hsa049130.92042298
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91764310
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91154339
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90512637
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.86110301
72Regulation of autophagy_Homo sapiens_hsa041400.84454078
73Staphylococcus aureus infection_Homo sapiens_hsa051500.84328919
74Lysine degradation_Homo sapiens_hsa003100.84012976
75Fatty acid elongation_Homo sapiens_hsa000620.83430418
76Starch and sucrose metabolism_Homo sapiens_hsa005000.82381864
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80537902
78Glucagon signaling pathway_Homo sapiens_hsa049220.78243982
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76054833
80Malaria_Homo sapiens_hsa051440.73970134
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.73370646
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71663189
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71478800
84Oxytocin signaling pathway_Homo sapiens_hsa049210.70839072
85Adherens junction_Homo sapiens_hsa045200.70015868
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68587370
87Bile secretion_Homo sapiens_hsa049760.67642852
88Viral myocarditis_Homo sapiens_hsa054160.67576862
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66658291
90ABC transporters_Homo sapiens_hsa020100.63402246
91Rheumatoid arthritis_Homo sapiens_hsa053230.63031318
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62417979
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61537897
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60593540
95Bladder cancer_Homo sapiens_hsa052190.59449445
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59017112
97Folate biosynthesis_Homo sapiens_hsa007900.55198782
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54404112
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53944372
100Tuberculosis_Homo sapiens_hsa051520.53778601
101Platelet activation_Homo sapiens_hsa046110.52711095
102Melanoma_Homo sapiens_hsa052180.51535489
103Endocytosis_Homo sapiens_hsa041440.51233485
104Toxoplasmosis_Homo sapiens_hsa051450.51056015
105Gastric acid secretion_Homo sapiens_hsa049710.50380598
106Circadian entrainment_Homo sapiens_hsa047130.50315473
107Prion diseases_Homo sapiens_hsa050200.49658427
108Chemical carcinogenesis_Homo sapiens_hsa052040.49509419
109Biosynthesis of amino acids_Homo sapiens_hsa012300.49503687
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48061225
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47958593
112MicroRNAs in cancer_Homo sapiens_hsa052060.47678237
113Inositol phosphate metabolism_Homo sapiens_hsa005620.47287466
114Chronic myeloid leukemia_Homo sapiens_hsa052200.46539032
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46142121
116Histidine metabolism_Homo sapiens_hsa003400.45393227
117Vitamin B6 metabolism_Homo sapiens_hsa007500.44784253
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44727100
119Glioma_Homo sapiens_hsa052140.44666515
120Type II diabetes mellitus_Homo sapiens_hsa049300.44324838
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44013696
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43832761
123cAMP signaling pathway_Homo sapiens_hsa040240.41416483
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.40532986
125Pentose phosphate pathway_Homo sapiens_hsa000300.39777248
126mTOR signaling pathway_Homo sapiens_hsa041500.38877270
127Renin secretion_Homo sapiens_hsa049240.38433067
128Pancreatic secretion_Homo sapiens_hsa049720.38271950
129Antigen processing and presentation_Homo sapiens_hsa046120.37828434
130TGF-beta signaling pathway_Homo sapiens_hsa043500.37255991
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.37242164
132Insulin secretion_Homo sapiens_hsa049110.37120534
133Prostate cancer_Homo sapiens_hsa052150.36501780
134Basal cell carcinoma_Homo sapiens_hsa052170.36061613
135Dorso-ventral axis formation_Homo sapiens_hsa043200.35971062
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35939965
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35042001
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.34387681
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33923479
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.32630588
141HIF-1 signaling pathway_Homo sapiens_hsa040660.32146380
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32091756
143Pathways in cancer_Homo sapiens_hsa052000.30978248
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30952096
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30108900
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30067435
147Acute myeloid leukemia_Homo sapiens_hsa052210.29843919
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29653899
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.28833401
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28227905
151Pancreatic cancer_Homo sapiens_hsa052120.28078045
152Retinol metabolism_Homo sapiens_hsa008300.27946986
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.27234818

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