COL6A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.76879091
2muscle filament sliding (GO:0030049)6.76879091
3Golgi transport vesicle coating (GO:0048200)6.66582070
4COPI coating of Golgi vesicle (GO:0048205)6.66582070
5skeletal muscle contraction (GO:0003009)6.06745503
6actin-mediated cell contraction (GO:0070252)5.84008054
7protein heterotrimerization (GO:0070208)5.79194849
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.08957192
9extracellular fibril organization (GO:0043206)5.05754657
10collagen fibril organization (GO:0030199)4.83352430
11regulation of skeletal muscle contraction (GO:0014819)4.79178936
12actin filament-based movement (GO:0030048)4.72407232
13COPII vesicle coating (GO:0048208)4.64544332
14endocrine pancreas development (GO:0031018)4.59893202
15sarcomere organization (GO:0045214)4.57468106
16type B pancreatic cell development (GO:0003323)4.54836506
17surfactant homeostasis (GO:0043129)4.44620543
18protein retention in ER lumen (GO:0006621)4.38235986
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.34329442
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.17279711
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.16518058
22fibril organization (GO:0097435)4.11458833
23glandular epithelial cell development (GO:0002068)4.09524616
24peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.05573980
25ER overload response (GO:0006983)4.01418593
26actomyosin structure organization (GO:0031032)4.00872902
27exocrine pancreas development (GO:0031017)3.94392835
28striated muscle contraction (GO:0006941)3.93010977
29signal peptide processing (GO:0006465)3.91504049
30positive regulation of myotube differentiation (GO:0010831)3.85820775
31negative regulation of potassium ion transmembrane transport (GO:1901380)3.84509441
32positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.84261081
33detection of calcium ion (GO:0005513)3.83365746
34chemical homeostasis within a tissue (GO:0048875)3.82415114
35neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.74467174
36negative regulation of norepinephrine secretion (GO:0010700)3.73449487
37peptide hormone processing (GO:0016486)3.73182645
38sequestering of metal ion (GO:0051238)3.71689735
39sequestering of extracellular ligand from receptor (GO:0035581)3.69053708
40negative regulation of protein localization to cell surface (GO:2000009)3.63567055
41positive regulation of myoblast differentiation (GO:0045663)3.62029798
42endocrine hormone secretion (GO:0060986)3.55408238
43insulin-like growth factor receptor signaling pathway (GO:0048009)3.54906140
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.47550127
45insulin secretion (GO:0030073)3.42031089
46cardiac myofibril assembly (GO:0055003)3.40128806
47* collagen metabolic process (GO:0032963)3.36616019
48bone trabecula formation (GO:0060346)3.33666004
49extracellular regulation of signal transduction (GO:1900115)3.30056899
50extracellular negative regulation of signal transduction (GO:1900116)3.30056899
51regulation of skeletal muscle cell differentiation (GO:2001014)3.25096890
52positive regulation of nuclease activity (GO:0032075)3.23619779
53positive regulation of glomerulus development (GO:0090193)3.22600977
54positive regulation of glycogen biosynthetic process (GO:0045725)3.21235342
55* multicellular organismal macromolecule metabolic process (GO:0044259)3.21038246
56* collagen catabolic process (GO:0030574)3.20232272
57* multicellular organismal metabolic process (GO:0044236)3.19274566
58columnar/cuboidal epithelial cell development (GO:0002066)3.15233452
59muscle cell fate commitment (GO:0042693)3.13777127
60vesicle coating (GO:0006901)3.09508369
61interleukin-1-mediated signaling pathway (GO:0070498)3.09127697
62face morphogenesis (GO:0060325)3.08884987
63regulation of corticosteroid hormone secretion (GO:2000846)3.08750408
64positive regulation of hormone biosynthetic process (GO:0046886)3.07978256
65skin morphogenesis (GO:0043589)3.06380833
66regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.06234789
67myofibril assembly (GO:0030239)3.03954547
68glandular epithelial cell differentiation (GO:0002067)3.03420658
69* multicellular organismal catabolic process (GO:0044243)3.02964721
70negative regulation of cardiac muscle hypertrophy (GO:0010614)3.01144583
71skeletal muscle tissue development (GO:0007519)3.00651082
72cell migration involved in heart development (GO:0060973)2.99016330
73plasma membrane repair (GO:0001778)2.97336523
74regulation of p38MAPK cascade (GO:1900744)2.97239587
75regulation of sarcomere organization (GO:0060297)2.96357619
76G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.95193193
77response to inactivity (GO:0014854)2.93825654
78myotube cell development (GO:0014904)2.92677216
79skeletal muscle fiber development (GO:0048741)2.92624989
80regulation of nuclease activity (GO:0032069)2.92587006
81regulation of cardiac muscle cell apoptotic process (GO:0010665)2.91294120
82inner ear receptor cell development (GO:0060119)2.89391880
83cardiac muscle contraction (GO:0060048)2.88543518
84relaxation of cardiac muscle (GO:0055119)2.88282095
85cellular response to unfolded protein (GO:0034620)2.87339933
86regulation of cardiac muscle hypertrophy (GO:0010611)2.87206439
87smooth muscle tissue development (GO:0048745)2.86230789
88striated muscle atrophy (GO:0014891)2.85803174
89regulation of glucocorticoid secretion (GO:2000849)2.85605067
90endoplasmic reticulum unfolded protein response (GO:0030968)2.84194868
91parturition (GO:0007567)2.83743248
92negative regulation of chondrocyte differentiation (GO:0032331)2.83696639
93regulation of myoblast differentiation (GO:0045661)2.81432373
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.80705591
95nitric oxide mediated signal transduction (GO:0007263)2.80137354
96regulation of vasculogenesis (GO:2001212)2.79990276
97muscle organ development (GO:0007517)2.79199143
98regulation of muscle hypertrophy (GO:0014743)2.78138860
99embryonic retina morphogenesis in camera-type eye (GO:0060059)2.77190872
100regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.77185144
101muscle structure development (GO:0061061)2.77132600
102hormone catabolic process (GO:0042447)2.75978169
103glycoprotein catabolic process (GO:0006516)2.75791893
104sarcoplasmic reticulum calcium ion transport (GO:0070296)2.75488940
105negative regulation of muscle hypertrophy (GO:0014741)2.75268306
106hippo signaling (GO:0035329)2.75118006
107retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74935187
108regulation of cardiac muscle cell differentiation (GO:2000725)2.72733980
109cellular sodium ion homeostasis (GO:0006883)2.72253948
110lactate metabolic process (GO:0006089)2.72246790
111ER-nucleus signaling pathway (GO:0006984)2.72231785
112intra-Golgi vesicle-mediated transport (GO:0006891)2.71709393
113negative regulation of catecholamine secretion (GO:0033604)2.71700300
114muscle contraction (GO:0006936)2.71427158
115cellular response to topologically incorrect protein (GO:0035967)2.70814606
116nephron epithelium morphogenesis (GO:0072088)2.70432166
117nephron tubule morphogenesis (GO:0072078)2.70432166
118interkinetic nuclear migration (GO:0022027)2.70112080
119skeletal muscle tissue regeneration (GO:0043403)2.69788671
120keratan sulfate catabolic process (GO:0042340)2.69043609
121regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.68583586
122positive regulation of glycogen metabolic process (GO:0070875)2.68531838
123vascular endothelial growth factor signaling pathway (GO:0038084)2.68232245
124muscle tissue development (GO:0060537)2.66809537
125peripheral nervous system axon ensheathment (GO:0032292)2.64956055
126myelination in peripheral nervous system (GO:0022011)2.64956055
127* extracellular matrix disassembly (GO:0022617)2.64796492
128blood vessel maturation (GO:0001955)2.64652465
129positive regulation of phosphatase activity (GO:0010922)2.64620128
130growth hormone secretion (GO:0030252)2.64309813
131negative regulation of fatty acid transport (GO:2000192)2.63046323
132renal tubule morphogenesis (GO:0061333)2.62560542
133extracellular matrix assembly (GO:0085029)2.62203474
134nucleus localization (GO:0051647)2.61808858
135lymphangiogenesis (GO:0001946)2.61389656
136prostate gland growth (GO:0060736)2.61227168
137negative regulation of cartilage development (GO:0061037)2.61175556
138positive regulation of steroid hormone secretion (GO:2000833)2.60731125
139regulation of insulin secretion (GO:0050796)2.60720842
140trabecula formation (GO:0060343)2.60484302
141embryonic camera-type eye morphogenesis (GO:0048596)2.60191106
142paraxial mesoderm development (GO:0048339)2.59444449
143regulation of type B pancreatic cell apoptotic process (GO:2000674)2.58788222
144positive regulation of fatty acid oxidation (GO:0046321)2.58726847
145regulation of steroid hormone secretion (GO:2000831)2.57548683
146striated muscle tissue development (GO:0014706)2.56750790
147myoblast fusion (GO:0007520)2.56127020
148regulation of glomerulus development (GO:0090192)2.56071440
149venous blood vessel morphogenesis (GO:0048845)2.55488715
150regulation of hexokinase activity (GO:1903299)2.54235016
151regulation of glucokinase activity (GO:0033131)2.54235016
152negative regulation of glycogen biosynthetic process (GO:0045719)2.53965322
153protein localization to Golgi apparatus (GO:0034067)2.53727196
154cellular response to vitamin D (GO:0071305)2.53614035
155muscle system process (GO:0003012)2.52995784
156regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.52174579
157atrioventricular valve morphogenesis (GO:0003181)2.51765946
158peptide hormone secretion (GO:0030072)2.50486023
159regulation of relaxation of muscle (GO:1901077)2.50107830
160regulation of striated muscle cell apoptotic process (GO:0010662)2.48673068
161peptide secretion (GO:0002790)2.48626751
162regulation of cardioblast differentiation (GO:0051890)2.48228434
163regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.48083895
164outflow tract septum morphogenesis (GO:0003148)2.47643532
165positive regulation of glycolytic process (GO:0045821)2.46594380
166cell differentiation involved in metanephros development (GO:0072202)2.46249732
167regulation of secondary heart field cardioblast proliferation (GO:0003266)2.45132135
168regulation of cardioblast proliferation (GO:0003264)2.45132135
169wound healing, spreading of epidermal cells (GO:0035313)2.44947757
170regulation of skeletal muscle fiber development (GO:0048742)2.44880172
171muscle atrophy (GO:0014889)2.44629319
172basement membrane organization (GO:0071711)2.44141210
173cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.43884217
174regulation of striated muscle contraction (GO:0006942)2.43231292
175positive regulation of endothelial cell differentiation (GO:0045603)2.42920292
176regulation of cell communication by electrical coupling (GO:0010649)2.41554731
177response to caffeine (GO:0031000)2.41179904
178bundle of His cell to Purkinje myocyte communication (GO:0086069)2.40562907
179cell communication involved in cardiac conduction (GO:0086065)2.39056768
180cardiac chamber formation (GO:0003207)2.39000724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.78070199
2ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.67976945
3GBX2_23144817_ChIP-Seq_PC3_Human2.62738498
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.49016045
5EZH2_22144423_ChIP-Seq_EOC_Human2.34805240
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.32259548
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.31523475
8GATA1_22025678_ChIP-Seq_K562_Human2.26235720
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24538779
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.19416119
11ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85256608
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84545983
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80848648
14CJUN_26792858_Chip-Seq_BT549_Human1.77265042
15DROSHA_22980978_ChIP-Seq_HELA_Human1.76280577
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.71359106
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69223332
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69072930
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.68518419
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68507612
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67446931
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67377577
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65465113
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61644649
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59361719
26CLOCK_20551151_ChIP-Seq_293T_Human1.56149652
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54708571
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54295271
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.54102659
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.53328984
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52951212
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49678595
33AR_21572438_ChIP-Seq_LNCaP_Human1.48954059
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47746425
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47663579
36NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45431662
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.45405577
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45078298
39SMAD3_21741376_ChIP-Seq_HESCs_Human1.44683430
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.44491843
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.43208076
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41625049
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41625049
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41258891
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39892089
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39189627
47TAF15_26573619_Chip-Seq_HEK293_Human1.38658945
48SMAD4_21799915_ChIP-Seq_A2780_Human1.37144034
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36878079
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35621551
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35330303
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35032594
53STAT3_23295773_ChIP-Seq_U87_Human1.34087931
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31941782
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31074310
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.30637981
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.30637981
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30187134
59FUS_26573619_Chip-Seq_HEK293_Human1.26599189
60BRD4_25478319_ChIP-Seq_HGPS_Human1.25297780
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.22460827
62SMAD4_21741376_ChIP-Seq_HESCs_Human1.22398420
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21948432
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.21893593
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.21883064
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.21504755
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21397937
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20571646
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19919328
70AHR_22903824_ChIP-Seq_MCF-7_Human1.19500884
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18543395
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18543395
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16883568
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16791218
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16452353
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.15982232
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15562296
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15136166
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14554028
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14386673
81TP53_16413492_ChIP-PET_HCT116_Human1.14214364
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14054348
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13748834
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13694244
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12189337
86P300_19829295_ChIP-Seq_ESCs_Human1.11717510
87AR_19668381_ChIP-Seq_PC3_Human1.11545434
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.11460716
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11430863
90KDM2B_26808549_Chip-Seq_REH_Human1.10275108
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09801273
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09433217
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09331041
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08456387
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08388906
96TCF4_23295773_ChIP-Seq_U87_Human1.08356701
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08060419
98* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08010499
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07291389
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06516618
101TP53_18474530_ChIP-ChIP_U2OS_Human1.06389728
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06009678
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05897704
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02323561
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.02182994
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.01960274
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01717632
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01690370
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00944086
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00771870
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00087729
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00025073
113GF1B_26923725_Chip-Seq_HPCs_Mouse0.99607487
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.99543972
115LXR_22158963_ChIP-Seq_LIVER_Mouse0.98918918
116FOXA2_19822575_ChIP-Seq_HepG2_Human0.97048349
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.97025836
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96511071
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96495271
120EZH2_27294783_Chip-Seq_ESCs_Mouse0.96461729
121TP63_23658742_ChIP-Seq_EP156T_Human0.93886904
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92934778
123RXR_22108803_ChIP-Seq_LS180_Human0.91752023
124NFYA_21822215_ChIP-Seq_K562_Human0.91597341
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.90749138
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88849696
127SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88642013
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88365709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.19770913
2MP0005275_abnormal_skin_tensile5.18134741
3MP0005503_abnormal_tendon_morphology4.31463931
4MP0002877_abnormal_melanocyte_morpholog3.54534011
5MP0010386_abnormal_urinary_bladder3.24443896
6MP0002837_dystrophic_cardiac_calcinosis3.09477996
7MP0009780_abnormal_chondrocyte_physiolo2.97093675
8MP0000678_abnormal_parathyroid_gland2.89941638
9MP0004043_abnormal_pH_regulation2.81279619
10MP0004272_abnormal_basement_membrane2.61853536
11MP0000013_abnormal_adipose_tissue2.37725491
12MP0003950_abnormal_plasma_membrane2.29490973
13MP0000751_myopathy2.28077579
14MP0000733_abnormal_muscle_development2.26909656
15MP0003122_maternal_imprinting2.24571288
16MP0005257_abnormal_intraocular_pressure2.21359713
17MP0002108_abnormal_muscle_morphology2.07878165
18MP0002693_abnormal_pancreas_physiology2.02233435
19MP0001944_abnormal_pancreas_morphology1.92898241
20MP0001958_emphysema1.89456438
21MP0003283_abnormal_digestive_organ1.82694933
22MP0002060_abnormal_skin_morphology1.82464920
23MP0005670_abnormal_white_adipose1.81713081
24MP0004145_abnormal_muscle_electrophysio1.76410173
25MP0002896_abnormal_bone_mineralization1.71067673
26MP0005220_abnormal_exocrine_pancreas1.70919050
27MP0010030_abnormal_orbit_morphology1.63041122
28MP0003941_abnormal_skin_development1.55526366
29MP0002876_abnormal_thyroid_physiology1.52638523
30MP0006054_spinal_hemorrhage1.51276085
31MP0005646_abnormal_pituitary_gland1.48002299
32MP0005508_abnormal_skeleton_morphology1.47479777
33MP0000003_abnormal_adipose_tissue1.47391824
34MP0004264_abnormal_extraembryonic_tissu1.44355786
35MP0002249_abnormal_larynx_morphology1.42938713
36MP0001542_abnormal_bone_strength1.40049174
37MP0003195_calcinosis1.39189710
38MP0003183_abnormal_peptide_metabolism1.38064100
39MP0005379_endocrine/exocrine_gland_phen1.37486930
40MP0005171_absent_coat_pigmentation1.35984891
41MP0003705_abnormal_hypodermis_morpholog1.35088829
42MP0004084_abnormal_cardiac_muscle1.34250652
43MP0004782_abnormal_surfactant_physiolog1.32571386
44MP0000538_abnormal_urinary_bladder1.32240993
45MP0009250_abnormal_appendicular_skeleto1.31786754
46MP0000767_abnormal_smooth_muscle1.31459097
47MP0002006_tumorigenesis1.30442855
48MP0000747_muscle_weakness1.27606545
49MP0002078_abnormal_glucose_homeostasis1.25789054
50MP0003279_aneurysm1.23812284
51MP0001879_abnormal_lymphatic_vessel1.22108700
52MP0002909_abnormal_adrenal_gland1.21160976
53MP0002269_muscular_atrophy1.18989429
54MP0003045_fibrosis1.14976146
55MP0005595_abnormal_vascular_smooth1.14225813
56MP0001661_extended_life_span1.14070228
57MP0009384_cardiac_valve_regurgitation1.14057714
58MP0010630_abnormal_cardiac_muscle1.11323309
59MP0002928_abnormal_bile_duct1.11087820
60MP0002295_abnormal_pulmonary_circulatio1.10657215
61MP0005375_adipose_tissue_phenotype1.08041523
62MP0004036_abnormal_muscle_relaxation1.05878109
63MP0005388_respiratory_system_phenotype1.04955920
64MP0002133_abnormal_respiratory_system1.04955920
65MP0003091_abnormal_cell_migration1.03619152
66MP0005369_muscle_phenotype1.02859425
67MP0001986_abnormal_taste_sensitivity1.02397385
68MP0000750_abnormal_muscle_regeneration1.00458497
69MP0002796_impaired_skin_barrier1.00220731
70MP0000163_abnormal_cartilage_morphology0.99074931
71MP0004215_abnormal_myocardial_fiber0.98016732
72MP0005666_abnormal_adipose_tissue0.95922061
73MP0000749_muscle_degeneration0.95911281
74MP0000383_abnormal_hair_follicle0.95545327
75MP0002168_other_aberrant_phenotype0.95479016
76MP0003252_abnormal_bile_duct0.92191375
77MP0005645_abnormal_hypothalamus_physiol0.91846525
78MP0002138_abnormal_hepatobiliary_system0.91331953
79MP0008004_abnormal_stomach_pH0.90835706
80MP0002106_abnormal_muscle_physiology0.90068986
81MP0000566_synostosis0.89550996
82MP0002166_altered_tumor_susceptibility0.89120250
83MP0001177_atelectasis0.89069221
84MP0003566_abnormal_cell_adhesion0.88919380
85MP0010678_abnormal_skin_adnexa0.88348504
86MP0005620_abnormal_muscle_contractility0.87578172
87MP0006072_abnormal_retinal_apoptosis0.87236859
88MP0003115_abnormal_respiratory_system0.86630144
89MP0010234_abnormal_vibrissa_follicle0.85356655
90MP0005385_cardiovascular_system_phenoty0.84434054
91MP0001544_abnormal_cardiovascular_syste0.84434054
92MP0003868_abnormal_feces_composition0.84010880
93MP0002128_abnormal_blood_circulation0.83744915
94MP0004087_abnormal_muscle_fiber0.83405432
95MP0003385_abnormal_body_wall0.82170179
96MP0004134_abnormal_chest_morphology0.81747103
97MP0002972_abnormal_cardiac_muscle0.80850788
98MP0010368_abnormal_lymphatic_system0.80489346
99MP0001243_abnormal_dermal_layer0.79485372
100MP0002638_abnormal_pupillary_reflex0.77100324
101MP0005330_cardiomyopathy0.76737860
102MP0002938_white_spotting0.76332690
103MP0003942_abnormal_urinary_system0.74648416
104MP0002115_abnormal_skeleton_extremities0.74043556
105MP0000266_abnormal_heart_morphology0.73837206
106MP0000534_abnormal_ureter_morphology0.73553218
107MP0009672_abnormal_birth_weight0.73472544
108MP0003953_abnormal_hormone_level0.73226799
109MP0004130_abnormal_muscle_cell0.72303157
110MP0000762_abnormal_tongue_morphology0.72193917
111MP0004085_abnormal_heartbeat0.72012790
112MP0000230_abnormal_systemic_arterial0.71989175
113MP0001299_abnormal_eye_distance/0.71556328
114MP0003935_abnormal_craniofacial_develop0.70892020
115MP0004484_altered_response_of0.70763279
116MP0006138_congestive_heart_failure0.70421555
117MP0005334_abnormal_fat_pad0.70356384
118MP0000681_abnormal_thyroid_gland0.70033844
119MP0003123_paternal_imprinting0.69389588
120MP0003119_abnormal_digestive_system0.69123482
121MP0001756_abnormal_urination0.68889899
122MP0005390_skeleton_phenotype0.68843943
123MP0005367_renal/urinary_system_phenotyp0.68736288
124MP0000516_abnormal_urinary_system0.68736288
125MP0000428_abnormal_craniofacial_morphol0.68525873
126MP0000462_abnormal_digestive_system0.68324545
127MP0001614_abnormal_blood_vessel0.68089018
128MP0001270_distended_abdomen0.67991787
129MP0002925_abnormal_cardiovascular_devel0.67802047
130MP0005076_abnormal_cell_differentiation0.67620429
131MP0004270_analgesia0.67392033
132MP0003121_genomic_imprinting0.67193204
133MP0004185_abnormal_adipocyte_glucose0.66877837
134MP0002127_abnormal_cardiovascular_syste0.66833224
135MP0008775_abnormal_heart_ventricle0.66681376
136MP0002114_abnormal_axial_skeleton0.66553495
137MP0000759_abnormal_skeletal_muscle0.65644889
138MP0002109_abnormal_limb_morphology0.64374106
139MP0005409_darkened_coat_color0.63309179
140MP0001175_abnormal_lung_morphology0.63291885
141MP0002332_abnormal_exercise_endurance0.62923231
142MP0002233_abnormal_nose_morphology0.62543426
143MP0002116_abnormal_craniofacial_bone0.61112729
144MP0003828_pulmonary_edema0.60764021
145MP0005023_abnormal_wound_healing0.60710440
146MP0002932_abnormal_joint_morphology0.59739092

Predicted human phenotypes

RankGene SetZ-score
1Ulnar deviation of the wrist (HP:0003049)7.09574776
2Calcaneovalgus deformity (HP:0001848)6.00188563
3Type 1 muscle fiber predominance (HP:0003803)5.68227327
4Deformed tarsal bones (HP:0008119)5.31617520
5Follicular hyperkeratosis (HP:0007502)5.18287350
6Absent phalangeal crease (HP:0006109)5.13978954
7Ankle contracture (HP:0006466)4.98209445
8Increased connective tissue (HP:0009025)4.95624923
9Trismus (HP:0000211)4.73016349
10Breech presentation (HP:0001623)4.66350458
11Fetal akinesia sequence (HP:0001989)4.33565074
12Hyperinsulinemic hypoglycemia (HP:0000825)4.30906069
13Protrusio acetabuli (HP:0003179)4.28775553
14Abnormal finger flexion creases (HP:0006143)4.28748065
15Hypoglycemic seizures (HP:0002173)4.24419328
16Slender build (HP:0001533)4.23547977
17Popliteal pterygium (HP:0009756)4.18874579
18Muscle fiber splitting (HP:0003555)4.14448040
19Mildly elevated creatine phosphokinase (HP:0008180)4.09913285
20Premature rupture of membranes (HP:0001788)4.09547358
21Malignant hyperthermia (HP:0002047)4.06515583
22Nemaline bodies (HP:0003798)4.04913386
23Chin dimple (HP:0010751)3.92382303
24Insulin-resistant diabetes mellitus (HP:0000831)3.81672548
25Abnormality of the calcaneus (HP:0008364)3.80009319
26Symptomatic seizures (HP:0011145)3.75490882
27Soft skin (HP:0000977)3.74520180
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.74309751
29Hyperglycemia (HP:0003074)3.72137313
30Broad metatarsal (HP:0001783)3.67702626
31Hypoglycemic coma (HP:0001325)3.66203393
32Metatarsus adductus (HP:0001840)3.65501519
33Hip contracture (HP:0003273)3.64479869
34Pancreatic islet-cell hyperplasia (HP:0004510)3.63786078
35Spinal rigidity (HP:0003306)3.58801085
36Aplasia of the musculature (HP:0100854)3.38610892
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.38585755
38Muscle fiber inclusion bodies (HP:0100299)3.37659681
39Aortic dissection (HP:0002647)3.25837554
40Striae distensae (HP:0001065)3.23566401
41Increased variability in muscle fiber diameter (HP:0003557)3.15382769
42Limited hip movement (HP:0008800)3.14586098
43Abnormality of the pancreatic islet cells (HP:0006476)3.00463499
44Abnormality of endocrine pancreas physiology (HP:0012093)3.00463499
45Hypokalemia (HP:0002900)3.00329899
46Mitral valve prolapse (HP:0001634)2.99360384
47Thin bony cortex (HP:0002753)2.98464499
48Generalized aminoaciduria (HP:0002909)2.95791863
49Bladder diverticulum (HP:0000015)2.93997136
50Large for gestational age (HP:0001520)2.93489220
51Atrophic scars (HP:0001075)2.89718601
52Fragile skin (HP:0001030)2.87795423
53Decreased circulating renin level (HP:0003351)2.84354053
54Abnormality of skeletal muscle fiber size (HP:0012084)2.83519263
55Cervical subluxation (HP:0003308)2.83006792
56Abnormal auditory evoked potentials (HP:0006958)2.80436819
57Cerebral aneurysm (HP:0004944)2.75765286
58Dilatation of the ascending aorta (HP:0005111)2.70340829
59Symphalangism affecting the phalanges of the hand (HP:0009773)2.69376101
60Ketoacidosis (HP:0001993)2.67896582
61Abnormal pancreas size (HP:0012094)2.63150338
62Hyperextensible skin (HP:0000974)2.59382316
63Cutaneous syndactyly (HP:0012725)2.54646196
64Abnormality of calcium-phosphate metabolism (HP:0100530)2.53700491
65Exercise-induced myalgia (HP:0003738)2.53421478
66Unilateral renal agenesis (HP:0000122)2.46706874
67Hyporeflexia of lower limbs (HP:0002600)2.46358332
68Spondylolisthesis (HP:0003302)2.44901845
69Duplicated collecting system (HP:0000081)2.43779566
70Abnormality of potassium homeostasis (HP:0011042)2.43169470
71Joint laxity (HP:0001388)2.42440552
72Calf muscle hypertrophy (HP:0008981)2.40550378
73Abnormality of the calf musculature (HP:0001430)2.40261766
74Shallow orbits (HP:0000586)2.37031342
75Amniotic constriction ring (HP:0009775)2.36058182
76Abnormality of placental membranes (HP:0011409)2.36058182
77Abnormality of the renal collecting system (HP:0004742)2.34014458
78Generalized amyotrophy (HP:0003700)2.29359991
79Tarsal synostosis (HP:0008368)2.28275686
80Osteomalacia (HP:0002749)2.27654572
81Knee flexion contracture (HP:0006380)2.25582261
82Abnormal delivery (HP:0001787)2.23649977
83Thin ribs (HP:0000883)2.20856043
84Aortic regurgitation (HP:0001659)2.18615791
85Mitral stenosis (HP:0001718)2.18076307
86Late onset (HP:0003584)2.17708721
87Long clavicles (HP:0000890)2.17618718
88Subaortic stenosis (HP:0001682)2.16996618
89Abnormality of the left ventricular outflow tract (HP:0011103)2.16996618
90Flexion contracture of toe (HP:0005830)2.16377261
91Joint contractures involving the joints of the feet (HP:0100492)2.16377261
92Ulnar deviation of finger (HP:0009465)2.10967132
93Scapular winging (HP:0003691)2.10348838
94Hepatoblastoma (HP:0002884)2.09244825
95Insulin resistance (HP:0000855)2.08719719
96Absent eyebrow (HP:0002223)2.08199200
97Muscle hypertrophy of the lower extremities (HP:0008968)2.07401032
98Neonatal short-limb short stature (HP:0008921)2.06043569
99Synostosis involving bones of the lower limbs (HP:0009138)2.05847124
100Synostosis involving bones of the feet (HP:0009140)2.05847124
101Overgrowth (HP:0001548)2.05018925
102Gingival overgrowth (HP:0000212)2.00566576
103Hypoplastic ischia (HP:0003175)2.00397918
104Distal arthrogryposis (HP:0005684)10.7236209
105Decreased subcutaneous fat (HP:0001002)1.96137425
106Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.96136604
107Wrist flexion contracture (HP:0001239)1.95715443
108Enlarged kidneys (HP:0000105)1.95166285
109Akinesia (HP:0002304)1.94971054
110Thoracolumbar scoliosis (HP:0002944)1.94562560
111Venous insufficiency (HP:0005293)1.93871949
112Flat cornea (HP:0007720)1.93713085
113Short 4th metacarpal (HP:0010044)1.93669526
114Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93669526
115Hyperkalemia (HP:0002153)1.92608385
116Hypoventilation (HP:0002791)1.91789564
117Osteolytic defects of the hand bones (HP:0009699)1.90768042
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.90768042
119Proximal amyotrophy (HP:0007126)1.89587182
120Alopecia of scalp (HP:0002293)1.89348072
121Peritonitis (HP:0002586)1.89177106
122Sudden death (HP:0001699)1.89009324
123Mask-like facies (HP:0000298)1.88478349
124Alacrima (HP:0000522)1.88256093
125Aneurysm (HP:0002617)1.86723269
126Neck muscle weakness (HP:0000467)1.85412869
127Hypercortisolism (HP:0001578)1.83739332
128Lipoatrophy (HP:0100578)1.83032612
129Patent foramen ovale (HP:0001655)1.82566105
130Bicornuate uterus (HP:0000813)1.82178194
131Abnormality of the neuromuscular junction (HP:0003398)1.81286691
132Fatigable weakness (HP:0003473)1.81286691
133Absent eyelashes (HP:0000561)1.81091880
134Gowers sign (HP:0003391)1.79838437
135Wide anterior fontanel (HP:0000260)1.78600731
136Abnormality of the ischium (HP:0003174)1.78473957
137Oligomenorrhea (HP:0000876)1.78465516
138Bell-shaped thorax (HP:0001591)1.78211237
139Abnormality of the intrinsic pathway (HP:0010989)1.77600283
140Hyperactive renin-angiotensin system (HP:0000841)1.77238709
141Abnormality of the lacrimal duct (HP:0011481)1.77046717
142Rectal prolapse (HP:0002035)1.76984065
143Difficulty running (HP:0009046)1.76708992
144Round ear (HP:0100830)1.76034041
145Nasolacrimal duct obstruction (HP:0000579)1.76015638
146Congenital glaucoma (HP:0001087)1.75213579
147Protruding ear (HP:0000411)1.75008099
148Aortic aneurysm (HP:0004942)1.74670340
149EMG: myopathic abnormalities (HP:0003458)1.74493918
150Cutaneous finger syndactyly (HP:0010554)1.74487088
151Abnormality of renin-angiotensin system (HP:0000847)1.74040181
152Pulmonary artery stenosis (HP:0004415)1.73544354
153Prolonged QT interval (HP:0001657)1.72967607
154Venous abnormality (HP:0002624)1.72572031
155Myotonia (HP:0002486)1.72402182
156Osteoarthritis (HP:0002758)1.72006443
157Lymphangioma (HP:0100764)1.71906848
158Ventricular tachycardia (HP:0004756)1.71774697
159Asymmetric septal hypertrophy (HP:0001670)1.71734569
160Neoplasm of the heart (HP:0100544)1.71038259
161Hypoplasia of the iris (HP:0007676)1.70114046
162Abnormality of the nasolacrimal system (HP:0000614)1.68625174
163Tubulointerstitial fibrosis (HP:0005576)1.65775063
164Infantile muscular hypotonia (HP:0008947)1.65739607
165Urinary glycosaminoglycan excretion (HP:0003541)1.65719388
166Mucopolysacchariduria (HP:0008155)1.65719388
167Rocker bottom foot (HP:0001838)1.65589326
168Right ventricular cardiomyopathy (HP:0011663)1.64455478
169Blue sclerae (HP:0000592)1.64066812
170Skin nodule (HP:0200036)1.60794046
171Genu recurvatum (HP:0002816)1.60716047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.91679737
2PIK3CG4.26014484
3TAOK33.26055321
4FRK2.99869493
5PRKD32.48994199
6MAPK152.46286373
7SIK12.46178682
8IRAK32.36825088
9EEF2K2.33446816
10LATS12.28325641
11PDGFRA2.19626406
12EPHA32.15506663
13MAP3K22.08886975
14OBSCN2.00046163
15PASK1.96205799
16TNIK1.93828799
17STK38L1.92665867
18AKT31.86781856
19BMPR1B1.80372173
20WNK41.79420159
21MAPK71.77632811
22DMPK1.64205865
23MAP3K71.61322918
24MAPKAPK31.56115527
25TRIB31.52187376
26TIE11.51320668
27IRAK11.49057968
28CDC42BPA1.48925133
29LATS21.47120243
30HIPK21.40624095
31BMPR21.33594185
32MOS1.27025826
33SGK21.26484721
34MAPK121.25938966
35PRKCH1.21960945
36WNK11.20514040
37RPS6KA21.16105831
38ZAK1.15864430
39FGFR31.11270244
40ERN11.07831609
41FLT31.06287359
42NEK91.03928951
43FGFR41.00548199
44SGK30.99723579
45CDK120.98678794
46EPHB20.97803739
47IRAK20.96755735
48SGK4940.93220621
49SGK2230.93220621
50PRKD20.92730174
51STK30.89651986
52TGFBR20.89644741
53KIT0.88626865
54CCNB10.88188156
55CAMK1G0.86645974
56RET0.86623441
57ERBB30.86614385
58BCKDK0.83703025
59PTK60.83350660
60CAMK1D0.80421274
61MAP3K130.80289804
62PRKAA10.80261147
63STK240.80189992
64MYLK0.79075965
65DDR20.78757192
66ACVR1B0.78578792
67PDK20.77585401
68RIPK10.77410397
69STK390.76853649
70MAP3K100.76293967
71FER0.75995344
72PKN20.75304224
73FGFR20.74759991
74PRKCE0.73922188
75PRKAA20.72844142
76PINK10.72793359
77TRPM70.72696238
78PAK20.72411575
79BRD40.72350744
80PDGFRB0.71923425
81IRAK40.69473381
82PTK20.67110063
83MET0.65860999
84TTN0.65609063
85CHUK0.65090179
86NLK0.64811957
87FGFR10.63983953
88JAK10.63894885
89RPS6KB10.63614997
90EPHB10.63382524
91MAP2K20.60859002
92PRKG10.60533067
93PRKD10.59901498
94TGFBR10.59288567
95MARK20.59031905
96MAPK40.56551978
97NEK60.56213852
98RPS6KL10.55580891
99RPS6KC10.55580891
100PTK2B0.55271564
101ERBB20.53290688
102MAP3K30.52375238
103MUSK0.51412166
104NTRK30.50734902
105WNK30.50100702
106OXSR10.49708471
107MELK0.49520206
108MTOR0.49451110
109PIK3CA0.47995247
110RPS6KB20.47951879
111CDK90.47768751
112ILK0.46598153
113MAP3K10.45406826
114CDK80.45282770
115RPS6KA60.45194059
116MAP3K60.45035963
117KDR0.44141930
118CDK30.44110066
119SGK10.44002111
120MAP2K10.43015952
121LRRK20.42059090
122PDPK10.42050275
123CLK10.40645464
124AKT20.39939577
125GSK3A0.39529899
126MST1R0.39179653
127PRPF4B0.38047104
128AKT10.36962493
129ADRBK10.36278223
130MAPK10.35878150
131ROCK10.35783653
132STK380.34672224
133MAP3K140.34568786
134ROCK20.33213834
135NUAK10.32488866
136JAK20.31573159
137ERBB40.31543250
138PRKACB0.30881524
139PRKACG0.30756100

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.76035627
2Protein export_Homo sapiens_hsa030603.99817227
3* Protein digestion and absorption_Homo sapiens_hsa049743.13785928
4Insulin secretion_Homo sapiens_hsa049112.74040033
5Sulfur metabolism_Homo sapiens_hsa009202.70301721
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.52232105
7* ECM-receptor interaction_Homo sapiens_hsa045122.45485752
8Type II diabetes mellitus_Homo sapiens_hsa049302.23668962
9Tight junction_Homo sapiens_hsa045302.01741878
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.64310143
11Insulin resistance_Homo sapiens_hsa049311.63257198
12Dilated cardiomyopathy_Homo sapiens_hsa054141.63043602
13Gastric acid secretion_Homo sapiens_hsa049711.62746200
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61203393
15Circadian rhythm_Homo sapiens_hsa047101.57807467
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55337275
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50843015
18* Focal adhesion_Homo sapiens_hsa045101.48641769
19Salivary secretion_Homo sapiens_hsa049701.45773922
20Oxytocin signaling pathway_Homo sapiens_hsa049211.45713753
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44908439
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.41683256
23Platelet activation_Homo sapiens_hsa046111.31802165
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28089070
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24691780
26Other glycan degradation_Homo sapiens_hsa005111.15575972
27Lysine degradation_Homo sapiens_hsa003101.12039299
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10091002
29Glucagon signaling pathway_Homo sapiens_hsa049221.10087377
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09822793
31Starch and sucrose metabolism_Homo sapiens_hsa005001.08530318
32Amoebiasis_Homo sapiens_hsa051461.08523466
33Phototransduction_Homo sapiens_hsa047441.07801254
34Pancreatic secretion_Homo sapiens_hsa049721.06855705
35Calcium signaling pathway_Homo sapiens_hsa040201.06209637
36Cocaine addiction_Homo sapiens_hsa050301.06159699
37N-Glycan biosynthesis_Homo sapiens_hsa005101.04936524
38Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04184190
39Melanogenesis_Homo sapiens_hsa049161.03951196
40Thyroid hormone synthesis_Homo sapiens_hsa049181.02692938
41Cardiac muscle contraction_Homo sapiens_hsa042601.01619096
42Glioma_Homo sapiens_hsa052141.00944601
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99686569
44Dorso-ventral axis formation_Homo sapiens_hsa043200.98522899
45Mineral absorption_Homo sapiens_hsa049780.97808683
46ABC transporters_Homo sapiens_hsa020100.97805366
47Taste transduction_Homo sapiens_hsa047420.97081618
48Ovarian steroidogenesis_Homo sapiens_hsa049130.96365858
49Hippo signaling pathway_Homo sapiens_hsa043900.94900856
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94805339
51Gap junction_Homo sapiens_hsa045400.93695638
52Selenocompound metabolism_Homo sapiens_hsa004500.92916399
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.92666941
54Type I diabetes mellitus_Homo sapiens_hsa049400.91872540
55Vibrio cholerae infection_Homo sapiens_hsa051100.90736917
56Bile secretion_Homo sapiens_hsa049760.90318917
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90152889
58Prostate cancer_Homo sapiens_hsa052150.87191052
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86873263
60Malaria_Homo sapiens_hsa051440.86185805
61Fatty acid degradation_Homo sapiens_hsa000710.84687499
62Adherens junction_Homo sapiens_hsa045200.83645396
63Prolactin signaling pathway_Homo sapiens_hsa049170.82901890
64Ras signaling pathway_Homo sapiens_hsa040140.81886228
65Renal cell carcinoma_Homo sapiens_hsa052110.81789795
66Notch signaling pathway_Homo sapiens_hsa043300.81257662
67Olfactory transduction_Homo sapiens_hsa047400.80485506
68Propanoate metabolism_Homo sapiens_hsa006400.79730096
69Insulin signaling pathway_Homo sapiens_hsa049100.79711513
70Rap1 signaling pathway_Homo sapiens_hsa040150.79300330
71Complement and coagulation cascades_Homo sapiens_hsa046100.78474992
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78351110
73Long-term depression_Homo sapiens_hsa047300.78278836
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77406495
75* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77144720
76Pathways in cancer_Homo sapiens_hsa052000.76833024
77AMPK signaling pathway_Homo sapiens_hsa041520.76277353
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75873261
79Lysosome_Homo sapiens_hsa041420.75278526
80Axon guidance_Homo sapiens_hsa043600.74710961
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.74139604
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73977839
83Pertussis_Homo sapiens_hsa051330.72844948
84Tryptophan metabolism_Homo sapiens_hsa003800.70585518
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.70369974
86FoxO signaling pathway_Homo sapiens_hsa040680.70345412
87Endometrial cancer_Homo sapiens_hsa052130.70211223
88Butanoate metabolism_Homo sapiens_hsa006500.69704521
89Estrogen signaling pathway_Homo sapiens_hsa049150.69129592
90Prion diseases_Homo sapiens_hsa050200.67590813
91Renin-angiotensin system_Homo sapiens_hsa046140.67236390
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64333458
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.63775029
94Amphetamine addiction_Homo sapiens_hsa050310.62753330
95Choline metabolism in cancer_Homo sapiens_hsa052310.62364820
96Hedgehog signaling pathway_Homo sapiens_hsa043400.60437925
97Renin secretion_Homo sapiens_hsa049240.59971196
98Long-term potentiation_Homo sapiens_hsa047200.59440355
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58704653
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56474600
101mTOR signaling pathway_Homo sapiens_hsa041500.56081764
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55830022
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55329637
104cAMP signaling pathway_Homo sapiens_hsa040240.54063960
105Phenylalanine metabolism_Homo sapiens_hsa003600.52264026
106Galactose metabolism_Homo sapiens_hsa000520.51282477
107beta-Alanine metabolism_Homo sapiens_hsa004100.49379729
108Fatty acid metabolism_Homo sapiens_hsa012120.48535326
109Serotonergic synapse_Homo sapiens_hsa047260.48493482
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.47904488
111Ether lipid metabolism_Homo sapiens_hsa005650.47789137
112Cholinergic synapse_Homo sapiens_hsa047250.47628234
113Colorectal cancer_Homo sapiens_hsa052100.46040788
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45478632
115Proteoglycans in cancer_Homo sapiens_hsa052050.45158680
116VEGF signaling pathway_Homo sapiens_hsa043700.44640394
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44231071
118Pancreatic cancer_Homo sapiens_hsa052120.44023654
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40867600
120Toxoplasmosis_Homo sapiens_hsa051450.40010625
121Small cell lung cancer_Homo sapiens_hsa052220.39941079
122PPAR signaling pathway_Homo sapiens_hsa033200.39746701
123Inositol phosphate metabolism_Homo sapiens_hsa005620.38434100
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36163979
125TGF-beta signaling pathway_Homo sapiens_hsa043500.35935732
126Sphingolipid metabolism_Homo sapiens_hsa006000.35090633
127Melanoma_Homo sapiens_hsa052180.34419137
128Glycerolipid metabolism_Homo sapiens_hsa005610.33766414
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33158966
130GnRH signaling pathway_Homo sapiens_hsa049120.33116466
131MicroRNAs in cancer_Homo sapiens_hsa052060.32126761
132Linoleic acid metabolism_Homo sapiens_hsa005910.32122470
133Basal cell carcinoma_Homo sapiens_hsa052170.31483223
134Fat digestion and absorption_Homo sapiens_hsa049750.31439256
135Circadian entrainment_Homo sapiens_hsa047130.30883506
136Thyroid cancer_Homo sapiens_hsa052160.29104428
137Bladder cancer_Homo sapiens_hsa052190.28362136
138MAPK signaling pathway_Homo sapiens_hsa040100.28297940
139Regulation of autophagy_Homo sapiens_hsa041400.27922236
140Wnt signaling pathway_Homo sapiens_hsa043100.27236047

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